FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LTA4H-BTBD11 (FusionGDB2 ID:50249)

Fusion Gene Summary for LTA4H-BTBD11

check button Fusion gene summary
Fusion gene informationFusion gene name: LTA4H-BTBD11
Fusion gene ID: 50249
HgeneTgene
Gene symbol

LTA4H

BTBD11

Gene ID

4048

121551

Gene nameleukotriene A4 hydrolaseBTB domain containing 11
Synonyms-ABTB2B
Cytomap

12q23.1

12q23.3

Type of geneprotein-codingprotein-coding
Descriptionleukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27ankyrin repeat and BTB/POZ domain-containing protein BTBD11ANK-repeat BTB domain containing proteinBTB (POZ) domain containing 11BTB/POZ domain-containing protein 11
Modification date2020031320200313
UniProtAcc

P09960

A6QL63

Ensembl transtripts involved in fusion geneENST00000413268, ENST00000228740, 
ENST00000552789, ENST00000548375, 
ENST00000280758, ENST00000420571, 
ENST00000490090, ENST00000357167, 
ENST00000494235, 
Fusion gene scores* DoF score9 X 11 X 4=3965 X 5 X 2=50
# samples 115
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: LTA4H [Title/Abstract] AND BTBD11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLTA4H(96396738)-BTBD11(107914264), # samples:3
Anticipated loss of major functional domain due to fusion event.LTA4H-BTBD11 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
LTA4H-BTBD11 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LTA4H-BTBD11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLTA4H

GO:0019370

leukotriene biosynthetic process

9774412|15078870

HgeneLTA4H

GO:0043171

peptide catabolic process

9774412|15078870|18804029


check buttonFusion gene breakpoints across LTA4H (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BTBD11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3U5-01ALTA4Hchr12

96396738

-BTBD11chr12

107914264

+
ChimerDB4SARCTCGA-DX-A3U5LTA4Hchr12

96396737

-BTBD11chr12

107914263

+


Top

Fusion Gene ORF analysis for LTA4H-BTBD11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000413268ENST00000280758LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
3UTR-3CDSENST00000413268ENST00000280758LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
3UTR-3CDSENST00000413268ENST00000420571LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
3UTR-3CDSENST00000413268ENST00000420571LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
3UTR-3CDSENST00000413268ENST00000490090LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
3UTR-3CDSENST00000413268ENST00000490090LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
3UTR-intronENST00000413268ENST00000357167LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
3UTR-intronENST00000413268ENST00000357167LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
3UTR-intronENST00000413268ENST00000494235LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
3UTR-intronENST00000413268ENST00000494235LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
5CDS-intronENST00000228740ENST00000357167LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
5CDS-intronENST00000228740ENST00000357167LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
5CDS-intronENST00000228740ENST00000494235LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
5CDS-intronENST00000228740ENST00000494235LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
5CDS-intronENST00000552789ENST00000357167LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
5CDS-intronENST00000552789ENST00000357167LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
5CDS-intronENST00000552789ENST00000494235LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
5CDS-intronENST00000552789ENST00000494235LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
Frame-shiftENST00000228740ENST00000280758LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
Frame-shiftENST00000228740ENST00000280758LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
Frame-shiftENST00000228740ENST00000420571LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
Frame-shiftENST00000228740ENST00000420571LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
Frame-shiftENST00000228740ENST00000490090LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
Frame-shiftENST00000228740ENST00000490090LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
Frame-shiftENST00000552789ENST00000280758LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
Frame-shiftENST00000552789ENST00000280758LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
Frame-shiftENST00000552789ENST00000420571LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
Frame-shiftENST00000552789ENST00000420571LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
Frame-shiftENST00000552789ENST00000490090LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
Frame-shiftENST00000552789ENST00000490090LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
intron-3CDSENST00000548375ENST00000280758LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
intron-3CDSENST00000548375ENST00000280758LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
intron-3CDSENST00000548375ENST00000420571LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
intron-3CDSENST00000548375ENST00000420571LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
intron-3CDSENST00000548375ENST00000490090LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
intron-3CDSENST00000548375ENST00000490090LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
intron-intronENST00000548375ENST00000357167LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
intron-intronENST00000548375ENST00000357167LTA4Hchr12

96396737

-BTBD11chr12

107914263

+
intron-intronENST00000548375ENST00000494235LTA4Hchr12

96396738

-BTBD11chr12

107914264

+
intron-intronENST00000548375ENST00000494235LTA4Hchr12

96396737

-BTBD11chr12

107914263

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for LTA4H-BTBD11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LTA4Hchr1296396737-BTBD11chr12107914263+8.79E-080.9999999
LTA4Hchr1296396737-BTBD11chr12107914263+8.79E-080.9999999
LTA4Hchr1296396737-BTBD11chr12107914263+8.79E-080.9999999
LTA4Hchr1296396737-BTBD11chr12107914263+8.79E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LTA4H-BTBD11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:96396738/:107914264)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LTA4H

P09960

BTBD11

A6QL63

FUNCTION: Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for LTA4H-BTBD11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for LTA4H-BTBD11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LTA4H-BTBD11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LTA4H-BTBD11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource