|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LTA4H-STAB2 (FusionGDB2 ID:50257) |
Fusion Gene Summary for LTA4H-STAB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LTA4H-STAB2 | Fusion gene ID: 50257 | Hgene | Tgene | Gene symbol | LTA4H | STAB2 | Gene ID | 4048 | 55576 |
| Gene name | leukotriene A4 hydrolase | stabilin 2 | |
| Synonyms | - | FEEL2|FELE-2|FELL2|FEX2|HARE|SCARH1 | |
| Cytomap | 12q23.1 | 12q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27 | stabilin-2CD44-like precursor FELLFAS1 EGF-like and X-link domain containing adhesion molecule-2fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-2hepatic hyaluronan clearance receptorhyaluronan receptor for end | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P09960 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000228740, ENST00000413268, ENST00000548375, ENST00000552789, | ENST00000388887, | |
| Fusion gene scores | * DoF score | 9 X 11 X 4=396 | 7 X 8 X 3=168 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/396*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LTA4H [Title/Abstract] AND STAB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LTA4H(96429139)-STAB2(104076983), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LTA4H | GO:0019370 | leukotriene biosynthetic process | 9774412|15078870 |
| Hgene | LTA4H | GO:0043171 | peptide catabolic process | 9774412|15078870|18804029 |
| Tgene | STAB2 | GO:0042742 | defense response to bacterium | 12077138 |
| Tgene | STAB2 | GO:0050830 | defense response to Gram-positive bacterium | 11829752 |
| Fusion gene breakpoints across LTA4H (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across STAB2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-3B-A9HL-01A | LTA4H | chr12 | 96429139 | - | STAB2 | chr12 | 104076983 | + |
Top |
Fusion Gene ORF analysis for LTA4H-STAB2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000228740 | ENST00000388887 | LTA4H | chr12 | 96429139 | - | STAB2 | chr12 | 104076983 | + |
| intron-3CDS | ENST00000413268 | ENST00000388887 | LTA4H | chr12 | 96429139 | - | STAB2 | chr12 | 104076983 | + |
| intron-3CDS | ENST00000548375 | ENST00000388887 | LTA4H | chr12 | 96429139 | - | STAB2 | chr12 | 104076983 | + |
| intron-3CDS | ENST00000552789 | ENST00000388887 | LTA4H | chr12 | 96429139 | - | STAB2 | chr12 | 104076983 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000228740 | LTA4H | chr12 | 96429139 | - | ENST00000388887 | STAB2 | chr12 | 104076983 | + | 5543 | 301 | 142 | 5151 | 1669 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000228740 | ENST00000388887 | LTA4H | chr12 | 96429139 | - | STAB2 | chr12 | 104076983 | + | 0.001207927 | 0.9987921 |
Top |
Fusion Genomic Features for LTA4H-STAB2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| LTA4H | chr12 | 96429138 | - | STAB2 | chr12 | 104076982 | + | 0.008754682 | 0.9912453 |
| LTA4H | chr12 | 96429138 | - | STAB2 | chr12 | 104076982 | + | 0.008754682 | 0.9912453 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for LTA4H-STAB2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:96429139/chr12:104076983) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LTA4H | . |
| FUNCTION: Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1137_1265 | 935 | 2552.0 | Domain | FAS1 4 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1343_1408 | 935 | 2552.0 | Domain | Laminin EGF-like 1 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1432_1470 | 935 | 2552.0 | Domain | EGF-like 11 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1471_1512 | 935 | 2552.0 | Domain | EGF-like 12 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1513_1554 | 935 | 2552.0 | Domain | EGF-like 13 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1555_1594 | 935 | 2552.0 | Domain | EGF-like 14 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1596_1724 | 935 | 2552.0 | Domain | FAS1 5 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1740_1881 | 935 | 2552.0 | Domain | FAS1 6 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 1957_2022 | 935 | 2552.0 | Domain | Laminin EGF-like 2 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2047_2081 | 935 | 2552.0 | Domain | EGF-like 15 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2082_2122 | 935 | 2552.0 | Domain | EGF-like 16 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2123_2165 | 935 | 2552.0 | Domain | EGF-like 17 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2198_2291 | 935 | 2552.0 | Domain | Link | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2311_2446 | 935 | 2552.0 | Domain | FAS1 7 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 953_992 | 935 | 2552.0 | Domain | EGF-like 10 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 994_1127 | 935 | 2552.0 | Domain | FAS1 3 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2480_2551 | 935 | 2552.0 | Topological domain | Cytoplasmic | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2459_2479 | 935 | 2552.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000228740 | - | 1 | 19 | 135_137 | 53 | 612.0 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000228740 | - | 1 | 19 | 267_272 | 53 | 612.0 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000228740 | - | 1 | 19 | 362_365 | 53 | 612.0 | Region | Inhibitor ARM1 binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000228740 | - | 1 | 19 | 564_566 | 53 | 612.0 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000413268 | - | 1 | 18 | 135_137 | 0 | 489.6666666666667 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000413268 | - | 1 | 18 | 267_272 | 0 | 489.6666666666667 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000413268 | - | 1 | 18 | 362_365 | 0 | 489.6666666666667 | Region | Inhibitor ARM1 binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000413268 | - | 1 | 18 | 564_566 | 0 | 489.6666666666667 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000552789 | - | 1 | 19 | 135_137 | 0 | 588.0 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000552789 | - | 1 | 19 | 267_272 | 0 | 588.0 | Region | Substrate binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000552789 | - | 1 | 19 | 362_365 | 0 | 588.0 | Region | Inhibitor ARM1 binding |
| Hgene | LTA4H | chr12:96429139 | chr12:104076983 | ENST00000552789 | - | 1 | 19 | 564_566 | 0 | 588.0 | Region | Substrate binding |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 108_148 | 935 | 2552.0 | Domain | EGF-like 1 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 156_193 | 935 | 2552.0 | Domain | EGF-like 2 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 195_236 | 935 | 2552.0 | Domain | EGF-like 3 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 237_276 | 935 | 2552.0 | Domain | EGF-like 4 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 322_362 | 935 | 2552.0 | Domain | EGF-like 5 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 371_505 | 935 | 2552.0 | Domain | FAS1 1 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 515_652 | 935 | 2552.0 | Domain | FAS1 2 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 736_776 | 935 | 2552.0 | Domain | EGF-like 6 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 826_866 | 935 | 2552.0 | Domain | EGF-like 7 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 867_909 | 935 | 2552.0 | Domain | EGF-like 8 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 910_952 | 935 | 2552.0 | Domain | EGF-like 9 | |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 20_2458 | 935 | 2552.0 | Topological domain | Extracellular |
Top |
Fusion Gene Sequence for LTA4H-STAB2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >50257_50257_1_LTA4H-STAB2_LTA4H_chr12_96429139_ENST00000228740_STAB2_chr12_104076983_ENST00000388887_length(transcript)=5543nt_BP=301nt AAGAAACTTCCTTTCCCGGCGTGCACCGCGAATCCCTCCTCCTCTTCTTTACCTCTCTCCCTCCTCCTCAGGTTCTCTATCGACGAGTCT GGTAGCTGAGCGTTGGGCTGTAGGTCGCTGTGCTGTGTGATCCCCCAGAGCCATGCCCGAGATAGTGGATACCTGTTCGTTGGCCTCTCC GGCTTCCGTCTGCCGGACCAAGCACCTGCACCTGCGCTGCAGCGTCGACTTTACTCGCCGGACGCTGACCGGGACTGCTGCTCTCACGGT CCAGTCTCAGGAGGACAATCTGCGCAGCCTGAATGAGTGTGAGTGCAAGAAAGGATTTCGAGGAAATGGGATTGACTGTGAACCAATAAC TTCATGCTTGGAACAAACCGGGAAATGTCATCCATTGGCAAGCTGTCAATCTACTTCGTCTGGTGTCTGGAGCTGTGTTTGTCAAGAGGG CTATGAAGGAGATGGCTTTCTGTGCTATGGAAACGCAGCAGTGGAATTGTCATTTCTCTCCGAAGCAGCTATATTTAACCGATGGATAAA TAATGCTTCTCTACAACCCACACTGTCAGCCACCTCAAACCTCACTGTCCTCGTGCCTTCCCAACAAGCTACTGAGGACATGGACCAGGA TGAGAAAAGCTTCTGGTTGTCACAGAGCAATATTCCAGCCCTAATAAAGTACCATATGCTACTAGGCACATACAGAGTGGCAGATCTGCA GACCCTGTCTTCTTCTGACATGTTGGCAACATCTTTGCAGGGCAACTTCCTTCACTTGGCAAAGGTGGATGGGAATATCACAATTGAAGG GGCCTCCATTGTCGATGGGGACAACGCAGCCACAAATGGAGTGATACACATCATCAACAAGGTGCTGGTCCCACAAAGACGTCTAACTGG CTCCTTACCAAACCTGCTCATGCGGCTGGAACAGATGCCTGACTATTCCATCTTCCGGGGCTACATCATTCAATATAATCTGGCGAATGC AATTGAGGCTGCCGATGCCTACACAGTGTTTGCTCCAAACAACAATGCCATCGAGAATTACATCAGGGAGAAGAAAGTCTTGTCTCTAGA GGAGGACGTCCTCCGGTATCATGTGGTCCTGGAGGAGAAACTCCTGAAGAATGACCTGCACAATGGCATGCATCGTGAGACCATGCTGGG TTTCTCCTATTTCCTTAGCTTCTTTCTCCATAATGACCAGCTCTATGTAAATGAGGCTCCAATAAACTACACCAATGTAGCCACTGATAA GGGAGTGATCCATGGCTTGGGAAAAGTTCTGGAAATTCAGAAGAACAGATGTGATAATAATGACACTACTATTATACGAGGAAGATGTAG GACATGCTCCTCAGAGCTGACCTGCCCATTCGGAACTAAATCTCTAGGTAATGAGAAGAGGAGATGCATCTATACCTCCTATTTCATGGG AAGACGAACCCTGTTTATTGGGTGCCAGCCAAAATGTGTGAGAACCGTCATTACGAGAGAATGCTGTGCCGGCTTCTTTGGCCCCCAATG CCAGCCCTGCCCAGGGAATGCCCAGAATGTCTGCTTTGGTAATGGCATCTGTTTGGATGGAGTGAATGGCACAGGTGTGTGTGAGTGTGG GGAGGGCTTCAGCGGCACAGCCTGCGAGACCTGCACCGAGGGCAAGTACGGCATCCACTGTGACCAAGCATGTTCTTGTGTCCATGGGAG ATGCAACCAAGGACCCTTGGGAGATGGCTCCTGTGACTGTGATGTTGGCTGGCGAGGAGTGCATTGTGACAATGCAACCACAGAAGACAA CTGCAATGGGACATGCCATACCAGCGCCAACTGCCTCACCAACTCAGATGGTACAGCTTCATGCAAGTGTGCAGCAGGATTCCAAGGAAA CGGGACCATCTGCACAGCAATCAATGCCTGTGAGATCAGCAATGGAGGTTGCTCTGCCAAGGCTGACTGTAAGAGAACCACCCCAGGAAG GCGAGTGTGCACGTGCAAAGCAGGCTACACGGGTGATGGCATTGTGTGCCTGGAAATCAACCCGTGTTTGGAGAACCATGGTGGCTGTGA CAAGAATGCGGAGTGCACACAGACAGGACCCAACCAGGCTGCCTGTAACTGTTTGCCAGCATACACTGGAGATGGAAAGGTCTGCACACT CATCAATGTCTGCTTAACTAAAAATGGCGGCTGTAGTGAATTTGCCATCTGCAACCACACTGGGCAAGTAGAAAGGACTTGTACTTGCAA GCCAAACTACATTGGAGATGGATTTACCTGCCGCGGCAGCATTTATCAGGAGCTTCCCAAGAACCCGAAAACTTCCCAGTATTTCTTCCA GTTGCAGGAGCATTTCGTGAAAGATCTGGTCGGCCCAGGCCCCTTCACTGTTTTTGCACCTTTATCTGCAGCCTTTGATGAGGAAGCTCG GGTTAAAGACTGGGACAAATACGGTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAA ATTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTATATAAACAATAAGGCTAAGAT CATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAGACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGA CAACTCTGGAAGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTT GCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACA GGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGA TCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCT GAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCAC CCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAG TAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGGTGCAGCCTGGTGAT ACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGT CTGCCTTGATCAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATT CGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGG GTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAA CACGTGTGAGTGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAA GGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCACAGAGATAGA CCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAG TCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGC CAAATGTGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACCTTTGACAA AGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTC AGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTA TGGACCTAGACCCAACAAGAGTGAAATGTGGGATGTCTTCTGCTATCGGATGAAAGATGTGAACTGCACCTGCAAGGTGGGCTATGTGGG AGATGGCTTCTCATGCAGTGGGAACCTGCTGCAGGTCCTGATGTCCTTCCCCTCACTCACAAACTTCCTGACGGAAGTGCTGGCCTATTC CAACAGCTCAGCTCGAGGCCGTGCATTTCTAGAACACCTGACTGACCTGTCCATCCGCGGCACCCTCTTTGTGCCACAGAACAGTGGGCT GGGGGAGAATGAGACCTTGTCTGGGCGGGACATCGAGCACCACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCTTGTCAATGGCAC CACCCTGCAAACGAGGCTGGGAAGCAAGCTGCTCATCACTGCCAGCCAGGACCCACTCCAACCGACGGAGACCAGGTTTGTTGATGGAAG AGCCATTCTGCAGTGGGACATCTTTGCCTCCAATGGGATCATTCATGTCATTTCCAGGCCTTTAAAAGCACCCCCTGCCCCCGTGACCTT GACCCACACTGGCTTGGGAGCAGGGATCTTCTTTGCCATCATCCTGGTGACTGGGGCTGTTGCCTTGGCTGCTTACTCCTACTTTCGGAT AAACCGGAGAACAATCGGCTTCCAGCATTTTGAGTCGGAAGAGGACATTAATGTTGCAGCTCTTGGCAAGCAGCAGCCTGAGAATATCTC GAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCCAGAACCTTCCTACGACCCCTTCACGGACTCTGAAGAACGGCAGCTTGAGGGCAA TGACCCCTTGAGGACACTGTGAGGGCCTGGACGGGAGATGCCAGCCATCACTCACTGCCACCTGGGCCATCAACTGTGAATTCTCAGCAC CAGTTGCCTTTTAGGAACGTAAAGTCCTTTAAGCACTCAGAAGCCATACCTCATCTCTCTGGCTGATCTGGGGGTTGTTTCTGTGGGTGA GAGATGTGTTGCTGTGCCCACCCAGTACAGCTTCCTCCTCTGACCCTTTGGCTCTTCTTCCTTTGTACTCTTCAGCTGGCACCTGCTCCA TTCTGCCCTACATGATGGGTAACTGTGATCTTTCTTCCCTGTTAGATTGTAAGCCTCCGTCTTTGTATCCCAGCCCCTAGCCCAGTGCCT >50257_50257_1_LTA4H-STAB2_LTA4H_chr12_96429139_ENST00000228740_STAB2_chr12_104076983_ENST00000388887_length(amino acids)=1669AA_BP=53 MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLNECECKKGFRGNGIDCEPITSCLEQTGKCHPLASCQS TSSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPALIKY HMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSI FRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVN EAPINYTNVATDKGVIHGLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVI TRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGIHCDQACSCVHGRCNQGPLGDGSCDCDVGW RGVHCDNATTEDNCNGTCHTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCL EINPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCRGSIYQE LPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISV SQSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWP TDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLG VAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQAC PGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCT PPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCK MTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATYNQ LSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFP SLTNFLTEVLAYSNSSARGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRLGSKLLITASQD PLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIILVTGAVALAAYSYFRINRRTIGFQHFESEEDIN -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for LTA4H-STAB2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | STAB2 | chr12:96429139 | chr12:104076983 | ENST00000388887 | 24 | 69 | 2504_2514 | 935.0 | 2552.0 | TMSB4X |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for LTA4H-STAB2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for LTA4H-STAB2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies