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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANXA2-CREM (FusionGDB2 ID:5027)

Fusion Gene Summary for ANXA2-CREM

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA2-CREM
Fusion gene ID: 5027
HgeneTgene
Gene symbol

ANXA2

CREM

Gene ID

302

1390

Gene nameannexin A2cAMP responsive element modulator
SynonymsANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IVCREM-2|ICER|hCREM-2
Cytomap

15q22.2

10p11.21

Type of geneprotein-codingprotein-coding
Descriptionannexin A2annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8epididymis secretory protein Li 270epididymis secretory sperm binding proteinlipocortin IIplacental anticoagulant protein IVprcAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICER
Modification date2020031320200313
UniProtAcc

P07355

Q03060

Ensembl transtripts involved in fusion geneENST00000332680, ENST00000396024, 
ENST00000421017, ENST00000451270, 
ENST00000557937, 		ENST00000333809, 
ENST00000337656, ENST00000342105, 
ENST00000344351, ENST00000345491, 
ENST00000348787, ENST00000354759, 
ENST00000356917, ENST00000361599, 
ENST00000374721, ENST00000374726, 
ENST00000374728, ENST00000374734, 
ENST00000395887, ENST00000395895, 
ENST00000429130, ENST00000439705, 
ENST00000460270, ENST00000463314, 
ENST00000463960, ENST00000468236, 
ENST00000469949, ENST00000473940, 
ENST00000474362, ENST00000474931, 
ENST00000479070, ENST00000484283, 
ENST00000487763, ENST00000488328, 
ENST00000488741, ENST00000489321, 
ENST00000489388, ENST00000490511, 
Fusion gene scores* DoF score22 X 20 X 7=308012 X 12 X 7=1008
# samples 2312
** MAII scorelog2(23/3080*10)=-3.74322458463789
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/1008*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANXA2 [Title/Abstract] AND CREM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANXA2(60643450)-CREM(35416495), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA2

GO:0001921

positive regulation of receptor recycling

22848640

HgeneANXA2

GO:0031340

positive regulation of vesicle fusion

2138016

HgeneANXA2

GO:0032804

negative regulation of low-density lipoprotein particle receptor catabolic process

22848640

HgeneANXA2

GO:0036035

osteoclast development

7961821

HgeneANXA2

GO:1905581

positive regulation of low-density lipoprotein particle clearance

22848640

HgeneANXA2

GO:1905597

positive regulation of low-density lipoprotein particle receptor binding

22848640

HgeneANXA2

GO:1905602

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

22848640

TgeneCREM

GO:0006355

regulation of transcription, DNA-templated

8206879


check buttonFusion gene breakpoints across ANXA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CREM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACD367600ANXA2chr15

60643450

+CREMchr10

35416495

-


Top

Fusion Gene ORF analysis for ANXA2-CREM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000332680ENST00000333809ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000337656ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000342105ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000344351ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000345491ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000348787ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000354759ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000356917ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000361599ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000374721ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000374726ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000374728ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000374734ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000395887ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000395895ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000429130ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000439705ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000460270ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000463314ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000463960ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000468236ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000469949ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000473940ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000474362ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000474931ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000479070ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000484283ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000487763ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000488328ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000488741ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000489321ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000489388ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000332680ENST00000490511ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000333809ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000337656ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000342105ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000344351ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000345491ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000348787ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000354759ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000356917ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000361599ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000374721ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000374726ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000374728ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000374734ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000395887ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000395895ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000429130ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000439705ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000460270ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000463314ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000463960ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000468236ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000469949ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000473940ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000474362ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000474931ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000479070ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000484283ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000487763ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000488328ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000488741ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000489321ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000489388ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000396024ENST00000490511ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000333809ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000337656ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000342105ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000344351ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000345491ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000348787ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000354759ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000356917ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000361599ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000374721ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000374726ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000374728ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000374734ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000395887ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000395895ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000429130ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000439705ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000460270ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000463314ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000463960ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000468236ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000469949ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000473940ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000474362ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000474931ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000479070ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000484283ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000487763ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000488328ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000488741ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000489321ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000489388ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000421017ENST00000490511ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000333809ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000337656ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000342105ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000344351ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000345491ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000348787ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000354759ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000356917ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000361599ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000374721ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000374726ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000374728ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000374734ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000395887ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000395895ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000429130ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000439705ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000460270ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000463314ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000463960ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000468236ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000469949ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000473940ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000474362ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000474931ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000479070ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000484283ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000487763ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000488328ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000488741ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000489321ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000489388ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000451270ENST00000490511ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000333809ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000337656ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000342105ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000344351ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000345491ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000348787ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000354759ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000356917ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000361599ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000374721ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000374726ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000374728ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000374734ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000395887ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000395895ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000429130ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000439705ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000460270ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000463314ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000463960ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000468236ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000469949ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000473940ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000474362ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000474931ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000479070ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000484283ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000487763ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000488328ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000488741ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000489321ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000489388ANXA2chr15

60643450

+CREMchr10

35416495

-
intron-intronENST00000557937ENST00000490511ANXA2chr15

60643450

+CREMchr10

35416495

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANXA2-CREM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANXA2-CREM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:60643450/:35416495)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANXA2

P07355

CREM

Q03060

FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). {ECO:0000269|PubMed:18799458, ECO:0000269|PubMed:22848640, ECO:0000269|PubMed:24808179}.FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANXA2-CREM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANXA2-CREM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANXA2-CREM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANXA2-CREM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource