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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LTBP2-NEK9 (FusionGDB2 ID:50282)

Fusion Gene Summary for LTBP2-NEK9

Fusion gene summary

Fusion gene information	Fusion gene name: LTBP2-NEK9
	Fusion gene ID: 50282
		Hgene	Tgene
	Gene symbol	LTBP2	NEK9
	Gene ID	4054	91754
	Gene name	latent transforming growth factor beta binding protein 3	NIMA related kinase 9
	Synonyms	DASS\|GPHYSD3\|LTBP-3\|LTBP2\|STHAG6\|pp6425	APUG\|LCCS10\|NC\|NERCC\|NERCC1
	Cytomap	11q13.1	14q24.3
	Type of gene	protein-coding	protein-coding
	Description	latent-transforming growth factor beta-binding protein 3latent TGF beta binding protein 3	serine/threonine-protein kinase Nek9NIMA (never in mitosis gene a)- related kinase 9nercc1 kinasenimA-related protein kinase 9
	Modification date	20200322	20200320
	UniProtAcc	Q14767	Q8TD19
	Ensembl transtripts involved in fusion gene	ENST00000261978, ENST00000556690, ENST00000557425,	ENST00000555763, ENST00000238616,
Fusion gene scores	* DoF score	5 X 5 X 2=50	4 X 7 X 3=84
	# samples	5	7
	** MAII score	log2(5/50*10)=0	log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LTBP2 [Title/Abstract] AND NEK9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LTBP2(74999129)-NEK9(75558181), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across LTBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NEK9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-1315-01A	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-

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Fusion Gene ORF analysis for LTBP2-NEK9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000261978	ENST00000555763	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-
5CDS-intron	ENST00000556690	ENST00000555763	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-
In-frame	ENST00000261978	ENST00000238616	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-
In-frame	ENST00000556690	ENST00000238616	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-
intron-3CDS	ENST00000557425	ENST00000238616	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-
intron-intron	ENST00000557425	ENST00000555763	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261978	LTBP2	chr14	74999129	-	ENST00000238616	NEK9	chr14	75558181	-	5526	2374	33	3080	1015
ENST00000556690	LTBP2	chr14	74999129	-	ENST00000238616	NEK9	chr14	75558181	-	5267	2115	23	2821	932

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261978	ENST00000238616	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-	0.011272243	0.9887278
ENST00000556690	ENST00000238616	LTBP2	chr14	74999129	-	NEK9	chr14	75558181	-	0.011673998	0.988326

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Fusion Genomic Features for LTBP2-NEK9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LTBP2-NEK9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:74999129/chr14:75558181)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LTBP2 Q14767	NEK9 Q8TD19
FUNCTION: May play an integral structural role in elastic-fiber architectural organization and/or assembly. {ECO:0000303\|PubMed:10743502, ECO:0000303\|PubMed:11104663}.	FUNCTION: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. {ECO:0000269\|PubMed:12840024, ECO:0000269\|PubMed:14660563, ECO:0000269\|PubMed:19941817}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

187_219

662

1822.0

Domain

EGF-like 1

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

396_428

662

1822.0

Domain

EGF-like 2

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

552_604

662

1822.0

Domain

TB 1

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

622_662

662

1822.0

Domain

EGF-like 3%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

375_377

662

1822.0

Motif

Cell attachment site

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

232_249

662

1822.0

Region

Note=Heparin-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

344_354

662

1822.0

Region

Note=Heparin-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

94_115

662

1822.0

Region

Note=Heparin-binding

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

892_939

744

980.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

752_760

744

980.0

Compositional bias

Note=Poly-Gly

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

765_888

744

980.0

Compositional bias

Note=Pro/Ser/Thr-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

856_1372

662

1822.0

Compositional bias

Note=Cys-rich

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1010_1050

662

1822.0

Domain

EGF-like 8%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1051_1092

662

1822.0

Domain

EGF-like 9%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1093_1134

662

1822.0

Domain

EGF-like 10%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1135_1175

662

1822.0

Domain

EGF-like 11%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1176_1217

662

1822.0

Domain

EGF-like 12%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1218_1258

662

1822.0

Domain

EGF-like 13%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1259_1302

662

1822.0

Domain

EGF-like 14%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1303_1344

662

1822.0

Domain

EGF-like 15%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1345_1387

662

1822.0

Domain

EGF-like 16%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1411_1463

662

1822.0

Domain

TB 3

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1485_1527

662

1822.0

Domain

EGF-like 17%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1528_1567

662

1822.0

Domain

EGF-like 18%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1584_1636

662

1822.0

Domain

TB 4

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1733_1773

662

1822.0

Domain

EGF-like 19%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1774_1818

662

1822.0

Domain

EGF-like 20%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

672_724

662

1822.0

Domain

TB 2

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

844_886

662

1822.0

Domain

EGF-like 4

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

887_929

662

1822.0

Domain

EGF-like 5%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

930_969

662

1822.0

Domain

EGF-like 6%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

970_1009

662

1822.0

Domain

EGF-like 7%3B calcium-binding

Hgene

LTBP2

chr14:74999129

chr14:75558181

ENST00000261978

1639_1821

662

1822.0

Region

C-terminal domain

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

52_308

744

980.0

Domain

Protein kinase

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

58_66

744

980.0

Nucleotide binding

ATP

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

388_444

744

980.0

Repeat

Note=RCC1 1

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

445_498

744

980.0

Repeat

Note=RCC1 2

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

499_550

744

980.0

Repeat

Note=RCC1 3

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

551_615

744

980.0

Repeat

Note=RCC1 4

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

616_668

744

980.0

Repeat

Note=RCC1 5

Tgene

NEK9

chr14:74999129

chr14:75558181

ENST00000238616

669_726

744

980.0

Repeat

Note=RCC1 6

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Fusion Gene Sequence for LTBP2-NEK9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50282_50282_1_LTBP2-NEK9_LTBP2_chr14_74999129_ENST00000261978_NEK9_chr14_75558181_ENST00000238616_length(transcript)=5526nt_BP=2374nt
CCTCGCTCCCTCTCCGGTAATGAGGGGGCTGAGCTGTCCCTCCGAGGAGGGGGCCTGGTGTGGATAAAAGAGACGAAAAAGCCGGGGGAG
GTTTCCAAAAATAAAACCGTCCGGGTCCCCTTCAGACGGCTGCAGGCACAGGGAGGAGGCGCGAAGGTGCAGCAGCCGTGCGAGCCCAGC
TGGAGTAGGAGCGCGGACTCGAGGCTCGGGGCGCGCAGCCCTCGTTCCGCCGAGAGCCGGGCCCCCAGTCGGCCGCTTCAGGGCCCCCTA
GACTCAGAGAAGCTGGCCGCCGGGCGGGGCCGGGAGAACAGCCCGCGGGCGTCCAGCGTGCCGACCACAAAGCTCTTCGCGGTGCCCGCG
CGCACCACTCTCCAGCCGCCCCGCGCCATGAGGCCGCGGACCAAAGCCCGCAGCCCGGGGCGCGCCCTGCGGAACCCCTGGAGAGGCTTC
CTGCCGCTCACCCTGGCTCTCTTCGTGGGCGCGGGTCATGCCCAAAGGGACCCCGTAGGGAGATACGAGCCGGCTGGTGGAGACGCGAAT
CGACTGCGGCGCCCTGGGGGCAGCTACCCGGCAGCGGCTGCAGCCAAGGTGTACAGTCTGTTCCGGGAGCAGGACGCGCCTGTCGCGGGC
TTGCAGCCCGTGGAGCGGGCCCAGCCGGGCTGGGGGAGCCCCAGGAGGCCCACCGAGGCGGAGGCCAGGAGGCCGTCCCGCGCGCAGCAG
TCGCGGCGTGTCCAGCCACCTGCGCAGACCCGGAGAAGCACTCCCCTGGGCCAGCAGCAACCAGCACCCCGGACCCGGGCCGCGCCGGCT
CTCCCACGCCTGGGGACCCCACAGCGGTCTGGGGCTGCGCCCCCAACCCCGCCGCGAGGGCGGCTCACGGGGAGGAACGTCTGCGGGGGA
CAGTGCTGCCCAGGATGGACAACAGCAAACAGCACCAACCACTGTATCAAACCCGTTTGCGAGCCGCCGTGCCAGAACCGGGGCTCCTGC
AGCCGCCCGCAGCTCTGTGTCTGCCGCTCTGGTTTCCGTGGAGCCCGCTGCGAGGAGGTCATTCCCGATGAGGAATTTGACCCCCAGAAC
TCCAGGCTGGCACCTCGACGCTGGGCCGAGCGTTCACCCAACCTGCGCAGGAGCAGTGCGGCTGGAGAGGGCACCTTGGCCAGAGCACAG
CCGCCAGCACCACAGTCGCCGCCCGCACCACAGTCGCCACCAGCTGGGACCCTGAGTGGCCTCAGCCAGACCCACCCTTCCCAGCAGCAC
GTGGGGTTGTCCCGCACTGTCCGACTTCACCCGACTGCCACGGCCAGTAGCCAGCTCTCTTCCAACGCCCTGCCCCCGGGACCAGGCCTT
GAGCAGAGAGATGGCACCCAACAGGCGGTACCTCTGGAGCACCCCTCATCCCCCTGGGGGCTGAACCTCACGGAGAAAATCAAGAAGATC
AAGATCGTCTTCACTCCCACCATCTGCAAGCAGACCTGTGCCCGTGGACACTGTGCCAACAGCTGTGAGAGGGGCGACACCACCACCCTG
TACAGCCAGGGCGGCCATGGGCACGATCCCAAGTCTGGCTTCCGCATCTATTTCTGCCAGATCCCCTGCCTGAACGGAGGCCGCTGCATC
GGCAGGGACGAATGCTGGTGCCCCGCCAACTCCACCGGGAAGTTCTGCCACCTGCCTATCCCGCAGCCGGACAGGGAGCCTCCAGGGAGG
GGGTCCCGCCCCAGGGCCTTGCTGGAAGCCCCACTGAAGCAGTCCACTTTCACACTGCCGCTCTCCAACCAGCTGGCCTCCGTGAACCCC
TCCCTGGTGAAGGTGCACATTCACCACCCACCCGAGGCCTCAGTGCAGATCCACCAGGTGGCCCAGGTGCGGGGCGGGGTGGAGGAGGCC
CTAGTGGAGAACAGCGTGGAGACCAGACCCCCGCCCTGGCTGCCTGCCAGCCCTGGCCACAGCCTCTGGGACAGCAACAACATCCCTGCT
CGGTCTGGAGAGCCCCCTCGGCCACTGCCCCCAGCAGCACCCAGGCCTCGAGGACTGCTGGGCCGGTGTTACCTGAACACTGTGAACGGA
CAGTGTGCCAACCCTCTGCTGGAGCTGACTACCCAGGAGGACTGCTGTGGCAGTGTGGGAGCCTTCTGGGGGGTGACTTTGTGTGCCCCA
TGCCCACCCAGACCAGCCTCCCCGGTGATTGAGAATGGCCAGCTGGAGTGTCCTCAGGGGTACAAGAGACTGAACCTCACTCACTGCCAA
GATATCAACGAGTGCTTGACCCTGGGCCTGTGCAAGGACGCGGAGTGTGTGAATACCAGGGGCAGCTACCTGTGCACATGCAGACCTGGC
CTCATGCTGGATCCATCGCGGAGCCGCTGTGTGTTGTTTCAGAGCTCTAGCCCGGGAGGAGGCGGCGGGGGCGGCGGTGGTGAAGAAGAG
GACAGTCAGCAGGAATCTGAAACTCCTGACCCAAGTGGAGGCTTCCGAGGAACAATGGAAGCAGACCGAGGAATGGAAGGTTTAATCAGT
CCCACAGAGGCCATGGGGAACAGTAATGGGGCCAGCAGCTCCTGTCCTGGCTGGCTTCGAAAGGAGCTGGAAAATGCAGAATTTATCCCC
ATGCCTGACAGCCCATCTCCTCTCAGTGCAGCGTTTTCAGAATCTGAGAAAGATACCCTGCCCTATGAAGAGCTGCAAGGACTCAAAGTG
GCCTCTGAAGCTCCTTTGGAACACAAACCCCAAGTAGAAGCCTCGTCACCTCGGCTGAATCCTGCAGTAACCTGTGCTGGGAAGGGAACA
CCACTGACTCCTCCTGCGTGTGCGTGCAGCTCTCTGCAGGTGGAGGTTGAGAGATTGCAGGGTCTGGTGTTAAAGTGTCTGGCTGAACAA
CAGAAGCTACAGCAAGAAAACCTCCAGATTTTTACCCAACTGCAGAAGTTGAACAAGAAATTAGAAGGAGGGCAGCAGGTGGGGATGCAT
TCCAAAGGAACTCAGACAGCAAAGGAAGAGATGGAAATGGATCCAAAGCCTGACTTAGATTCAGATTCCTGGTGCCTCCTGGGAACAGAC
TCCTGTAGACCCAGCCTCTAGTCTCCTGAGCCTGTAGAGCCCCCAGGAGACTGGGACCCAAAGAACTTCACAGCACACTTACCGAATGCA
GAGAGCAGCTTTCCTGGCTTTGTTCACTTGCAGAAAAGGAGCGCAAGGCAGAGGCTCTGAAGCACTTTCCTTGTACATTTGGAGAGTGGC
ATTGCCTTTTAGATAGGATCTAGGAGTGATTTTATTGTTTTGGAGAATGGAAGGGCCCCCATGGCCCTGGCTTTGTCATCAGTGACTGCC
ATAGCAACAGCAGCTCTGTACCTCATCTGTTGATCCCACCTTTGAAGAGGAGACACAGTGCTCACCTTAATTGCGCTGGTAGCAGCTTAT
ATCCCATGTATCATTTTCACCATTGATTGGAAGCTGCCTTGGGAATTCAGTACCAGGCATTACCCCTCTGGGTGGGAGAGGGAGAAGTGT
AAAGTTGGAGTGGGCTGGAATCAGGTGTGGCCCGCCCAGTGTCCTCTGCAGAGTGGTGAAGTAGTCTGGCCCTCTTGGGAGCCCTGAGTC
CAGGAAAATATGTCTGATGGAGTCAATCTAGGGCTTGTTTCGAAAAAGTTCAGTTACTCTGTGCAGCTAAATGCTTTAGGAGGAAAGGTA
GGCTTAGGTTGCTTTTCCTCTGAGGGTTGATTGAAATTTCTTCAGTGAGGAATAGAGAAAGGGCAGGACCCTCCTCATCACACAGCTGGT
GTTTCAGGCTGTGACCAATGCAGGGTGGGATTTCCTAACTGTGGATGAGGGGATGAGGTGTCTCTGAGGGATGAGGTGTCTCAGAGAATT
GAGTCCATGGGGCAGTCAGAATAGCCTTAAGAGAAAATCATGAAGGAGAAGAGGTCCTCCTTTAGCTGCCTCTACTTGGTATCTTAGAGA
GGGCTTAGAGGGCTCTCAGTCTTCTGCCCATGAAAAGACTTCTTTGAGCCTCTGCCTTCATGGCTCTTAGGGTTCTGATCTTGATATCAG
CAGCCCCAACCACTTTCTTTCTGAATGTCTAGTCAGTATTTTTCCCCTTTTGGTGTTTTATGAAGCCATGTGGTAACGAATGAATCTGTA
TCATTTTTCCTACCTGAGTGGCCCAAAGCCAGCACCAAACCCTGGGAGTCCCTGAAGCCTAACAGAACAGGTAGAACTTGCAAAAGGAAT
TTGGCTGAGAGCTCACTTCTAATCCTGTACTCACTGTGTCTTTGTAGATAGAAACAAGCTAGCTTTACCAAAGAGAAATAGTGTCATAGA
AGAACAAAACTTCATATAGAAAGTTCTAGGCAAGTATTTGATGGTTTCCTTAAGGATGTGAGCTTTGTATTTCCACCTAGCCTTGTAAAA
TGTTCCTGTGGTATTTTGTGTCACACATCCTACCTTTGATGAGTCTCACATCCCACCTTCCTATAAACAGCTAAATTAATTTTGTTTCAT
CTTCCCCAGACCAAAATGTTTGATAATCTTATCAACATTGTGGGAGGTCTTGTGCAATGGAAATTTTGCCATTTCTCCAAAACTGGTGGC
ATAAAGGCTGATGCTTGGGGAGAACCCCATTGCTCGGGACAGGCAACTCTGTTCAATGGGATCTTCTTTGGTTTGATGTTCCCATTGTTT
TCTCAGTTCTGGGAAGCCTAGTACATTAGTACTAATGTAATCACTGAAACCTTTTCTTGAAATAAGGGAAGCAGCCAAACTTTGATTAAA
GTTGCAAGTTCTGGGGACTTGCGGGGGTTGTCATAAACTGTAACAGTGGGTTTTGGTTCAGCATGTAAATGCAACTTTGATTTTCTTGAG
GACCGATTGACCTGTCATGTCCCTGTATCCTCATGCTCATCATCTCAGCAGGCCTGAGAGGCTGGGTCAGTTTGGGTGTTCATCATGAGG
ATTGCTTCTGCCATGGAGCTGATGGACATGGGCAGGTTGCTGAGAAGGTGGGGTGAAAGTGAGTGCCGGGGGTGGGTGAGTGCCCTGGTC
TTGTTCATAGGGGAGCCTTTCCCTAGCAGTGGAACGCTGTGGTCATTTTCTCTAGCATATTCCCTTGGGAAGTCTAGATTTGCTATTAAT
CTGGCTGAGAATCTAAGTTCTGTGCCTTAGAGACAGTTTGCACTTTCCCATATTGTGCCTGGGACAGCCATATGATTTTTTTTCCCACCA
AACAAGTATGCAAACAGAAACCAGTTCAAAGGGGGATGGAGTAAAAGATGAGGCAGTAGAAATGCCTTTGAATGGTTTTCTGTAGCTAAT
TCTCTTTAAATTTTGTCCTGCTTTTTTTCTTTATGCAGTGCTAGGTGTTTTAAGTTTTCTAGTAGTATTGCTTTTGAGTTACAGTATAAC
CTGAGTTACTCCTCTGCTCTAACATTGTTGCAGAAGAACTAGTTTATTGTTAGCCAGGTTGCTTGAAAGGTTGAGAGTGGAGTGGTTTGG

>50282_50282_1_LTBP2-NEK9_LTBP2_chr14_74999129_ENST00000261978_NEK9_chr14_75558181_ENST00000238616_length(amino acids)=1015AA_BP=781
MSLRGGGLVWIKETKKPGEVSKNKTVRVPFRRLQAQGGGAKVQQPCEPSWSRSADSRLGARSPRSAESRAPSRPLQGPLDSEKLAAGRGR
ENSPRASSVPTTKLFAVPARTTLQPPRAMRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSYPA
AAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSG
AAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAER
SPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVP
LEHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANS
TGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPP
PWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIE
NGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVLFQSSSPGGGGGGGGGEEEDSQQESETPDP
SGGFRGTMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASEAPLEHKPQ
VEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVERLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEM

--------------------------------------------------------------
>50282_50282_2_LTBP2-NEK9_LTBP2_chr14_74999129_ENST00000556690_NEK9_chr14_75558181_ENST00000238616_length(transcript)=5267nt_BP=2115nt
AGGGCCCCCTAGACTCAGAGAAGCTGGCCGCCGGGCGGGGCCGGGAGAACAGCCCGCGGGCGTCCAGCGTGCCGACCACAAAGCTCTTCG
CGGTGCCCGCGCGCACCACTCTCCAGCCGCCCCGCGCCATGAGGCCGCGGACCAAAGCCCGCAGCCCGGGGCGCGCCCTGCGGAACCCCT
GGAGAGGCTTCCTGCCGCTCACCCTGGCTCTCTTCGTGGGCGCGGGTCATGCCCAAAGGGACCCCGTAGGGAGATACGAGCCGGCTGGTG
GAGACGCGAATCGACTGCGGCGCCCTGGGGGCAGCTACCCGGCAGCGGCTGCAGCCAAGGTGTACAGTCTGTTCCGGGAGCAGGACGCGC
CTGTCGCGGGCTTGCAGCCCGTGGAGCGGGCCCAGCCGGGCTGGGGGAGCCCCAGGAGGCCCACCGAGGCGGAGGCCAGGAGGCCGTCCC
GCGCGCAGCAGTCGCGGCGTGTCCAGCCACCTGCGCAGACCCGGAGAAGCACTCCCCTGGGCCAGCAGCAACCAGCACCCCGGACCCGGG
CCGCGCCGGCTCTCCCACGCCTGGGGACCCCACAGCGGTCTGGGGCTGCGCCCCCAACCCCGCCGCGAGGGCGGCTCACGGGGAGGAACG
TCTGCGGGGGACAGTGCTGCCCAGGATGGACAACAGCAAACAGCACCAACCACTGTATCAAACCCGTTTGCGAGCCGCCGTGCCAGAACC
GGGGCTCCTGCAGCCGCCCGCAGCTCTGTGTCTGCCGCTCTGGTTTCCGTGGAGCCCGCTGCGAGGAGGTCATTCCCGATGAGGAATTTG
ACCCCCAGAACTCCAGGCTGGCACCTCGACGCTGGGCCGAGCGTTCACCCAACCTGCGCAGGAGCAGTGCGGCTGGAGAGGGCACCTTGG
CCAGAGCACAGCCGCCAGCACCACAGTCGCCGCCCGCACCACAGTCGCCACCAGCTGGGACCCTGAGTGGCCTCAGCCAGACCCACCCTT
CCCAGCAGCACGTGGGGTTGTCCCGCACTGTCCGACTTCACCCGACTGCCACGGCCAGTAGCCAGCTCTCTTCCAACGCCCTGCCCCCGG
GACCAGGCCTTGAGCAGAGAGATGGCACCCAACAGGCGGTACCTCTGGAGCACCCCTCATCCCCCTGGGGGCTGAACCTCACGGAGAAAA
TCAAGAAGATCAAGATCGTCTTCACTCCCACCATCTGCAAGCAGACCTGTGCCCGTGGACACTGTGCCAACAGCTGTGAGAGGGGCGACA
CCACCACCCTGTACAGCCAGGGCGGCCATGGGCACGATCCCAAGTCTGGCTTCCGCATCTATTTCTGCCAGATCCCCTGCCTGAACGGAG
GCCGCTGCATCGGCAGGGACGAATGCTGGTGCCCCGCCAACTCCACCGGGAAGTTCTGCCACCTGCCTATCCCGCAGCCGGACAGGGAGC
CTCCAGGGAGGGGGTCCCGCCCCAGGGCCTTGCTGGAAGCCCCACTGAAGCAGTCCACTTTCACACTGCCGCTCTCCAACCAGCTGGCCT
CCGTGAACCCCTCCCTGGTGAAGGTGCACATTCACCACCCACCCGAGGCCTCAGTGCAGATCCACCAGGTGGCCCAGGTGCGGGGCGGGG
TGGAGGAGGCCCTAGTGGAGAACAGCGTGGAGACCAGACCCCCGCCCTGGCTGCCTGCCAGCCCTGGCCACAGCCTCTGGGACAGCAACA
ACATCCCTGCTCGGTCTGGAGAGCCCCCTCGGCCACTGCCCCCAGCAGCACCCAGGCCTCGAGGACTGCTGGGCCGGTGTTACCTGAACA
CTGTGAACGGACAGTGTGCCAACCCTCTGCTGGAGCTGACTACCCAGGAGGACTGCTGTGGCAGTGTGGGAGCCTTCTGGGGGGTGACTT
TGTGTGCCCCATGCCCACCCAGACCAGCCTCCCCGGTGATTGAGAATGGCCAGCTGGAGTGTCCTCAGGGGTACAAGAGACTGAACCTCA
CTCACTGCCAAGATATCAACGAGTGCTTGACCCTGGGCCTGTGCAAGGACGCGGAGTGTGTGAATACCAGGGGCAGCTACCTGTGCACAT
GCAGACCTGGCCTCATGCTGGATCCATCGCGGAGCCGCTGTGTGTTGTTTCAGAGCTCTAGCCCGGGAGGAGGCGGCGGGGGCGGCGGTG
GTGAAGAAGAGGACAGTCAGCAGGAATCTGAAACTCCTGACCCAAGTGGAGGCTTCCGAGGAACAATGGAAGCAGACCGAGGAATGGAAG
GTTTAATCAGTCCCACAGAGGCCATGGGGAACAGTAATGGGGCCAGCAGCTCCTGTCCTGGCTGGCTTCGAAAGGAGCTGGAAAATGCAG
AATTTATCCCCATGCCTGACAGCCCATCTCCTCTCAGTGCAGCGTTTTCAGAATCTGAGAAAGATACCCTGCCCTATGAAGAGCTGCAAG
GACTCAAAGTGGCCTCTGAAGCTCCTTTGGAACACAAACCCCAAGTAGAAGCCTCGTCACCTCGGCTGAATCCTGCAGTAACCTGTGCTG
GGAAGGGAACACCACTGACTCCTCCTGCGTGTGCGTGCAGCTCTCTGCAGGTGGAGGTTGAGAGATTGCAGGGTCTGGTGTTAAAGTGTC
TGGCTGAACAACAGAAGCTACAGCAAGAAAACCTCCAGATTTTTACCCAACTGCAGAAGTTGAACAAGAAATTAGAAGGAGGGCAGCAGG
TGGGGATGCATTCCAAAGGAACTCAGACAGCAAAGGAAGAGATGGAAATGGATCCAAAGCCTGACTTAGATTCAGATTCCTGGTGCCTCC
TGGGAACAGACTCCTGTAGACCCAGCCTCTAGTCTCCTGAGCCTGTAGAGCCCCCAGGAGACTGGGACCCAAAGAACTTCACAGCACACT
TACCGAATGCAGAGAGCAGCTTTCCTGGCTTTGTTCACTTGCAGAAAAGGAGCGCAAGGCAGAGGCTCTGAAGCACTTTCCTTGTACATT
TGGAGAGTGGCATTGCCTTTTAGATAGGATCTAGGAGTGATTTTATTGTTTTGGAGAATGGAAGGGCCCCCATGGCCCTGGCTTTGTCAT
CAGTGACTGCCATAGCAACAGCAGCTCTGTACCTCATCTGTTGATCCCACCTTTGAAGAGGAGACACAGTGCTCACCTTAATTGCGCTGG
TAGCAGCTTATATCCCATGTATCATTTTCACCATTGATTGGAAGCTGCCTTGGGAATTCAGTACCAGGCATTACCCCTCTGGGTGGGAGA
GGGAGAAGTGTAAAGTTGGAGTGGGCTGGAATCAGGTGTGGCCCGCCCAGTGTCCTCTGCAGAGTGGTGAAGTAGTCTGGCCCTCTTGGG
AGCCCTGAGTCCAGGAAAATATGTCTGATGGAGTCAATCTAGGGCTTGTTTCGAAAAAGTTCAGTTACTCTGTGCAGCTAAATGCTTTAG
GAGGAAAGGTAGGCTTAGGTTGCTTTTCCTCTGAGGGTTGATTGAAATTTCTTCAGTGAGGAATAGAGAAAGGGCAGGACCCTCCTCATC
ACACAGCTGGTGTTTCAGGCTGTGACCAATGCAGGGTGGGATTTCCTAACTGTGGATGAGGGGATGAGGTGTCTCTGAGGGATGAGGTGT
CTCAGAGAATTGAGTCCATGGGGCAGTCAGAATAGCCTTAAGAGAAAATCATGAAGGAGAAGAGGTCCTCCTTTAGCTGCCTCTACTTGG
TATCTTAGAGAGGGCTTAGAGGGCTCTCAGTCTTCTGCCCATGAAAAGACTTCTTTGAGCCTCTGCCTTCATGGCTCTTAGGGTTCTGAT
CTTGATATCAGCAGCCCCAACCACTTTCTTTCTGAATGTCTAGTCAGTATTTTTCCCCTTTTGGTGTTTTATGAAGCCATGTGGTAACGA
ATGAATCTGTATCATTTTTCCTACCTGAGTGGCCCAAAGCCAGCACCAAACCCTGGGAGTCCCTGAAGCCTAACAGAACAGGTAGAACTT
GCAAAAGGAATTTGGCTGAGAGCTCACTTCTAATCCTGTACTCACTGTGTCTTTGTAGATAGAAACAAGCTAGCTTTACCAAAGAGAAAT
AGTGTCATAGAAGAACAAAACTTCATATAGAAAGTTCTAGGCAAGTATTTGATGGTTTCCTTAAGGATGTGAGCTTTGTATTTCCACCTA
GCCTTGTAAAATGTTCCTGTGGTATTTTGTGTCACACATCCTACCTTTGATGAGTCTCACATCCCACCTTCCTATAAACAGCTAAATTAA
TTTTGTTTCATCTTCCCCAGACCAAAATGTTTGATAATCTTATCAACATTGTGGGAGGTCTTGTGCAATGGAAATTTTGCCATTTCTCCA
AAACTGGTGGCATAAAGGCTGATGCTTGGGGAGAACCCCATTGCTCGGGACAGGCAACTCTGTTCAATGGGATCTTCTTTGGTTTGATGT
TCCCATTGTTTTCTCAGTTCTGGGAAGCCTAGTACATTAGTACTAATGTAATCACTGAAACCTTTTCTTGAAATAAGGGAAGCAGCCAAA
CTTTGATTAAAGTTGCAAGTTCTGGGGACTTGCGGGGGTTGTCATAAACTGTAACAGTGGGTTTTGGTTCAGCATGTAAATGCAACTTTG
ATTTTCTTGAGGACCGATTGACCTGTCATGTCCCTGTATCCTCATGCTCATCATCTCAGCAGGCCTGAGAGGCTGGGTCAGTTTGGGTGT
TCATCATGAGGATTGCTTCTGCCATGGAGCTGATGGACATGGGCAGGTTGCTGAGAAGGTGGGGTGAAAGTGAGTGCCGGGGGTGGGTGA
GTGCCCTGGTCTTGTTCATAGGGGAGCCTTTCCCTAGCAGTGGAACGCTGTGGTCATTTTCTCTAGCATATTCCCTTGGGAAGTCTAGAT
TTGCTATTAATCTGGCTGAGAATCTAAGTTCTGTGCCTTAGAGACAGTTTGCACTTTCCCATATTGTGCCTGGGACAGCCATATGATTTT
TTTTCCCACCAAACAAGTATGCAAACAGAAACCAGTTCAAAGGGGGATGGAGTAAAAGATGAGGCAGTAGAAATGCCTTTGAATGGTTTT
CTGTAGCTAATTCTCTTTAAATTTTGTCCTGCTTTTTTTCTTTATGCAGTGCTAGGTGTTTTAAGTTTTCTAGTAGTATTGCTTTTGAGT
TACAGTATAACCTGAGTTACTCCTCTGCTCTAACATTGTTGCAGAAGAACTAGTTTATTGTTAGCCAGGTTGCTTGAAAGGTTGAGAGTG

>50282_50282_2_LTBP2-NEK9_LTBP2_chr14_74999129_ENST00000556690_NEK9_chr14_75558181_ENST00000238616_length(amino acids)=932AA_BP=698
MAAGRGRENSPRASSVPTTKLFAVPARTTLQPPRAMRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRR
PGGSYPAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQTRRSTPLGQQQPAPRTRAAPALPRL
GTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLA
PRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRD
GTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDE
CWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVEN
SVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPR
PASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVLFQSSSPGGGGGGGGGEEEDSQQ
ESETPDPSGGFRGTMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEKDTLPYEELQGLKVASEA
PLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVERLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LTBP2-NEK9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	NEK9	chr14:74999129	chr14:75558181	ENST00000238616		17	22	732_891	744.3333333333334	980.0	NEK6

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LTBP2-NEK9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LTBP2-NEK9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source