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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LTBP4-STAB1 (FusionGDB2 ID:50299)

Fusion Gene Summary for LTBP4-STAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: LTBP4-STAB1
Fusion gene ID: 50299
HgeneTgene
Gene symbol

LTBP4

STAB1

Gene ID

8425

23166

Gene namelatent transforming growth factor beta binding protein 4stabilin 1
SynonymsARCL1C|LTBP-4|LTBP4L|LTBP4SCLEVER-1|FEEL-1|FELE-1|FEX1|SCARH2|STAB-1
Cytomap

19q13.2

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionlatent-transforming growth factor beta-binding protein 4latent transforming growth factor-beta binding protein 4Lstabilin-1MS-1 antigencommon lymphatic endothelial and vascular endothelial receptor-1fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scave
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000602240, ENST00000204005, 
ENST00000243562, ENST00000308370, 
ENST00000396819, ENST00000545697, 
ENST00000321725, 
Fusion gene scores* DoF score8 X 10 X 7=5603 X 3 X 2=18
# samples 103
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LTBP4 [Title/Abstract] AND STAB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLTBP4(41125336)-STAB1(52556687), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLTBP4

GO:0030162

regulation of proteolysis

9660815

TgeneSTAB1

GO:0007267

cell-cell signaling

12077138

TgeneSTAB1

GO:0042742

defense response to bacterium

12077138


check buttonFusion gene breakpoints across LTBP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STAB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF872672LTBP4chr19

41125336

+STAB1chr3

52556687

+


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Fusion Gene ORF analysis for LTBP4-STAB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000602240ENST00000321725LTBP4chr19

41125336

+STAB1chr3

52556687

+
In-frameENST00000204005ENST00000321725LTBP4chr19

41125336

+STAB1chr3

52556687

+
In-frameENST00000243562ENST00000321725LTBP4chr19

41125336

+STAB1chr3

52556687

+
In-frameENST00000308370ENST00000321725LTBP4chr19

41125336

+STAB1chr3

52556687

+
In-frameENST00000396819ENST00000321725LTBP4chr19

41125336

+STAB1chr3

52556687

+
In-frameENST00000545697ENST00000321725LTBP4chr19

41125336

+STAB1chr3

52556687

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000204005LTBP4chr1941125336+ENST00000321725STAB1chr352556687+43443219031851061
ENST00000545697LTBP4chr1941125336+ENST00000321725STAB1chr352556687+4089296402930976
ENST00000308370LTBP4chr1941125336+ENST00000321725STAB1chr352556687+44553330032961098
ENST00000396819LTBP4chr1941125336+ENST00000321725STAB1chr352556687+427131461731121031
ENST00000243562LTBP4chr1941125336+ENST00000321725STAB1chr352556687+18857606901745351

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000204005ENST00000321725LTBP4chr1941125336+STAB1chr352556687+0.0039603170.9960396
ENST00000545697ENST00000321725LTBP4chr1941125336+STAB1chr352556687+0.0055352930.9944647
ENST00000308370ENST00000321725LTBP4chr1941125336+STAB1chr352556687+0.0054335410.99456644
ENST00000396819ENST00000321725LTBP4chr1941125336+STAB1chr352556687+0.0046890650.99531096
ENST00000243562ENST00000321725LTBP4chr1941125336+STAB1chr352556687+0.0033849320.9966151

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Fusion Genomic Features for LTBP4-STAB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LTBP4-STAB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:41125336/chr3:52556687)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069110_14802571.0DomainEGF-like 1
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691128_125302571.0DomainFAS1 4
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691327_139202571.0DomainLaminin EGF-like 1
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691416_145402571.0DomainEGF-like 10
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691455_149602571.0DomainEGF-like 11
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691497_153902571.0DomainEGF-like 12
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691540_158202571.0DomainEGF-like 13
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069156_19302571.0DomainEGF-like 2
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691582_170802571.0DomainFAS1 5
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691724_186402571.0DomainFAS1 6
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069195_22902571.0DomainEGF-like 3
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250691966_203102571.0DomainLaminin EGF-like 2
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250692056_209002571.0DomainEGF-like 14
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250692091_213102571.0DomainEGF-like 15
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250692132_217402571.0DomainEGF-like 16
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250692206_230102571.0DomainLink
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250692322_245902571.0DomainFAS1 7
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069232_27102571.0DomainEGF-like 4
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069356_49402571.0DomainFAS1 1
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069506_64102571.0DomainFAS1 2
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069728_76802571.0DomainEGF-like 5
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069818_85802571.0DomainEGF-like 6
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069861_90302571.0DomainEGF-like 7
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069904_94602571.0DomainEGF-like 8
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069947_98602571.0DomainEGF-like 9
TgeneSTAB1chr19:41125336chr3:52556687ENST00000321725069988_111802571.0DomainFAS1 3
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250692500_257002571.0Topological domainCytoplasmic
TgeneSTAB1chr19:41125336chr3:52556687ENST0000032172506926_247802571.0Topological domainExtracellular
TgeneSTAB1chr19:41125336chr3:52556687ENST000003217250692479_249902571.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341119_117501624.0Compositional biasNote=Pro-rich
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341407_149201624.0Compositional biasNote=Pro-rich
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134478_56501624.0Compositional biasNote=Pro-rich
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134549_111801624.0Compositional biasNote=Cys-rich
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341049_109001624.0DomainEGF-like 12%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341181_123501624.0DomainTB 3
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341253_129501624.0DomainEGF-like 13%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341296_133701624.0DomainEGF-like 14%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341349_140201624.0DomainTB 4
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134149_18101624.0DomainEGF-like 1
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341533_157301624.0DomainEGF-like 15
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+1341574_161801624.0DomainEGF-like 16
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134287_33901624.0DomainTB 1
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134357_39701624.0DomainEGF-like 2%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134407_45901624.0DomainTB 2
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134545_58601624.0DomainEGF-like 3
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134587_62801624.0DomainEGF-like 4%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134629_67001624.0DomainEGF-like 5%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134671_70801624.0DomainEGF-like 6%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134710_75101624.0DomainEGF-like 7%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134752_79301624.0DomainEGF-like 8%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134834_87701624.0DomainEGF-like 9%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134878_91901624.0DomainEGF-like 10%3B calcium-binding
HgeneLTBP4chr19:41125336chr3:52556687ENST00000308370+134920_96001624.0DomainEGF-like 11%3B calcium-binding


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Fusion Gene Sequence for LTBP4-STAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50299_50299_1_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000204005_STAB1_chr3_52556687_ENST00000321725_length(transcript)=4344nt_BP=3219nt
ATGGGAGACGTAAAAGCGTTGCTGTTTGTCGCTGCTGCCCGGGCCAGACGTCTAGGAGGAGCCGCTGCATCCGAGTCCCTGGCTGTCTCC
GAAGCCTTCTGCAGGGTCCGAAGCTGCCAGCCCAAAAAGTGTGCAGGCCCCCAGCGGTGCCTGAACCCAGTGCCTGCAGTGCCCAGTCCC
AGCCCCAGCGTGAGGAAGAGACAGGTGTCCCTCAACTGGCAGCCACTGACGCTCCAGGAGGCCAGAGCTCTACTGAAGCGGCGGCGGCCC
CGGGGGCCAGGGGGCCGGGGACTACTGAGAAGGAGGCCCCCACAGCGTGCCCCCGCTGGCAAGGCCCCGGTCCTGTGTCCCTTGATCTGT
CACAATGGCGGTGTGTGCGTGAAGCCTGACCGCTGCCTCTGTCCCCCGGACTTCGCTGGCAAGTTCTGCCAGTTGCACTCCTCGGGCGCC
CGGCCCCCGGCCCCGGCTGTACCAGGCCTCACCCGCTCCGTGTACACTATGCCACTGGCCAACCACCGCGACGACGAGCACGGCGTGGCA
TCTATGGTGAGCGTCCACGTGGAGCACCCGCAGGAGGCGTCGGTGGTGGTGCACCAGGTGGAGCGTGTGTCTGGCCCTTGGGAGGAGGCG
GACGCTGAGGCGGTGGCGCGGGCGGAAGCGGCGGCGCGGGCGGAGGCGGCAGCGCCCTACACGGTGTTGGCACAGAGCGCGCCGCGGGAG
GACGGCTACTCAGATGCCTCGGGCTTCGGTTACTGCTTTCGGGAGCTGCGCGGAGGCGAATGCGCGTCCCCGCTGCCCGGGCTCCGGACG
CAGGAGGTCTGCTGCCGAGGGGCCGGCTTGGCCTGGGGCGTTCACGACTGTCAGCTGTGCTCCGAGCGCCTGGGGAACTCCGAAAGAGTG
AGCGCCCCAGATGGACCTTGTCCAACCGGCTTTGAAAGAGTTAATGGGTCCTGCGAAGATGTGGATGAGTGCGCGACTGGCGGGCGCTGC
CAGCACGGCGAGTGTGCAAACACGCGCGGCGGGTACACGTGTGTGTGCCCCGACGGCTTTCTGCTCGACTCGTCCCGCAGCAGCTGCATC
TCCCAACACGTGATCTCAGAGGCCAAAGGGCCCTGCTTCCGCGTGCTCCGCGACGGCGGCTGTTCGCTGCCCATTCTGCGGAACATCACT
AAACAGATCTGCTGCTGCAGCCGCGTAGGCAAGGCCTGGGGCCGGGGCTGCCAGCTCTGCCCACCCTTCGGCTCAGAGGGTTTCCGGGAG
ATCTGCCCGGCTGGTCCTGGTTACCACTACTCGGCCTCCGACCTCCGCTACAACACCAGACCCCTGGGCCAGGAGCCACCCCGAGTGTCA
CTCAGCCAGCCTCGTACCCTGCCAGCCACCTCTCGGCCATCTGCAGGCTTTCTGCCCACCCATCGCCTGGAGCCCCGGCCTGAACCCCGG
CCCGATCCCCGGCCCGGCCCTGAGCTTCCCTTGCCCAGCATCCCTGCCTGGACTGGTCCTGAGATTCCTGAATCAGGTCCCTCCTCCGGC
ATGTGTCAGCGCAACCCCCAGGTCTGCGGCCCAGGACGCTGCATTTCCCGGCCCAGCGGCTACACCTGCGCTTGCGACTCTGGCTTCCGG
CTCAGCCCCCAGGGCACCCGATGCATTGATGTGGACGAATGTCGCCGCGTGCCCCCGCCCTGTGCTCCCGGGCGCTGCGAGAACTCACCA
GGCAGCTTCCGCTGCGTGTGCGGCCCGGGCTTCCGAGCCGGCCCACGGGCTGCGGAATGCCTGGATGTGGACGAGTGCCACCGCGTGCCG
CCGCCGTGTGACCTCGGGCGCTGCGAGAACACGCCAGGCAGCTTCCTGTGCGTGTGCCCCGCCGGGTACCAGGCTGCACCGCACGGAGCC
AGCTGCCAGGATGTGGATGAATGCACCCAGAGCCCAGGCCTGTGTGGCCGAGGGGCCTGCAAGAACCTGCCTGGCTCTTTCCGCTGTGTT
TGCCCGGCTGGCTTCCGGGGCTCGGCGTGTGAAGAGGATGTGGATGAGTGTGCCCAGGAGCCGCCGCCCTGTGGGCCCGGCCGCTGTGAC
AACACGGCAGGCTCCTTTCACTGTGCCTGCCCTGCTGGCTTCCGCTCCCGAGGGCCCGGGGCCCCCTGCCAAGATGTGGATGAGTGTGCC
CGAAGCCCCCCACCCTGCACCTACGGCCGGTGTGAGAACACAGAAGGCAGCTTCCAGTGTGTCTGCCCCATGGGCTTCCAACCCAACACT
GCTGGCTCCGAGTGCGAGGATGTGGATGAGTGTGAGAACCACCTCGCATGCCCTGGGCAGGAGTGTGTGAACTCGCCCGGCTCCTTCCAG
TGCAGGACCTGTCCTTCTGGCCACCACCTGCACCGTGGCAGATGCACTGATGTGGACGAATGCAGTTCGGGTGCCCCTCCCTGTGGTCCC
CACGGCCACTGCACTAACACCGAAGGCTCCTTCCGCTGCAGCTGCGCGCCAGGCTACCGGGCGCCGTCGGGTCGGCCCGGGCCCTGCGCA
GACGTGAACGAGTGCCTGGAGGGCGATTTCTGCTTCCCTCACGGCGAGTGCCTCAACACTGACGGCTCCTTTGCCTGTACTTGTGCCCCT
GGCTACCGACCCGGACCCCGCGGAGCCTCTTGCCTCGACGTTGACGAGTGCAGCGAGGAGGACCTTTGCCAGAGCGGCATCTGTACCAAC
ACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACACCGCGCTGGCCCGGACCTCGCCTCCTGCCTCGACGTGGACGAATGTCGCGAG
CGAGGCCCAGCCCTGTGCGGGTCGCAGCGCTGTGAGAACTCTCCCGGCTCCTACCGCTGTGTCCGGGACTGCGATCCTGGGTACCACGCG
GGCCCCGAGGGCACCTGTGACGATGTGGATGAGTGCCAAGAATATGGTCCCGAGATTTGTGGAGCCCAGCGTTGTGAGAACACCCCTGGC
TCCTACCGCTGCACACCAGCCTGTGACCCTGGCTATCAGCCCACGCCAGGGGGCGGATGCCAGGATGTGGACGAATGCCGGAACCGGTCC
TTCTGCGGTGCCCACGCCGTGTGCCAGAACCTGCCCGGCTCCTTCCAGTGCCTCTGTGACCAGTACGAGGGGGCACGGGATGGGCGTCAC
TGCGTGGCAACAGCCCGGAAGAGTTTGACCCCATGACTGGACGCTGTGTTCCCCCACGAACTTCTGCTGTCTCTGCTGCCCAGCAGCTGG
GCTTCCACCTGTGCCTCATGGGCTGGCTGGCCAATGGCTCCACTGCCCACCCTGTGGTTTTCCCTGTGGCGGACTGTGGCAATGGTCGGG
TGGGCATAGTCAGCCTGGGTGCCCGCAAGAACCTCTCAGAACGCTGGGATGCCTACTGCTTCCGTGTGCAAGATGTGGCCTGCCGATGCC
GAAATGGCTTCGTGGGTGACGGGATCAGCACGTGCAATGGGAAGCTGCTGGATGTGCTGGCTGCCACTGCCAACTTCTCCACCTTCTATG
GGATGCTATTGGGCTATGCCAATGCCACCCAGCGGGGTCTCGACTTCCTGGACTTCCTGGATGATGAGCTCACGTATAAGACACTCTTCG
TCCCTGTCAATGAAGGCTTTGTGGACAACATGACGCTGAGTGGCCCAGACTTGGAGCTGCATGCCTCCAACGCCACCCTCCTAAGTGCCA
ACGCCAGCCAGGGGAAGTTGCTTCCGGCCCACTCAGGCCTCAGCCTCATCATCAGTGACGCAGGCCCTGACAACAGTTCCTGGGCCCCTG
TGGCCCCAGGGACAGTTGTGGTTAGCCGTATCATTGTGTGGGACATCATGGCCTTCAATGGCATCATCCATGCTCTGGCCAGCCCCCTCC
TGGCACCCCCACAGCCCCAGGCAGTGCTGGCGCCTGAAGCCCCACCTGTGGCGGCAGGCGTGGGGGCTGTGCTTGCCGCTGGAGCACTGC
TTGGCTTGGTGGCCGGAGCTCTCTACCTCCGTGCCCGAGGCAAGCCCATGGGCTTTGGCTTCTCTGCCTTCCAGGCGGAAGATGATGCTG
ATGACGACTTCTCACCGTGGCAAGAAGGGACCAACCCCACCCTGGTCTCTGTCCCCAACCCTGTCTTTGGCAGCGACACCTTTTGTGAAC
CCTTCGATGACTCACTGCTGGAGGAGGACTTCCCTGACACCCAGAGGATCCTCACAGTCAAGTGACGAGGCTGGGGCTGAAAGCAGAAGC
ATGCACAGGGAGGAGACCACTTTTATTGCTTGTCTGGGTGGATGGGGCAGGAGGGGCTGAGGGCCTGTCCCAGACAATAAAGGTGCCCTC

>50299_50299_1_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000204005_STAB1_chr3_52556687_ENST00000321725_length(amino acids)=1061AA_BP=
MGDVKALLFVAAARARRLGGAAASESLAVSEAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRP
RGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVA
SMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRT
QEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI
SQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVS
LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR
LSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGA
SCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECA
RSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP
HGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTN
TDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPG

--------------------------------------------------------------
>50299_50299_2_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000243562_STAB1_chr3_52556687_ENST00000321725_length(transcript)=1885nt_BP=760nt
AGAAGAGGGCGAAAAGGGGAAAACGAGTTTTTAGCCGGGGTATTCCAGCAGGATCAGGGGGCAGCTGGTGGGAGTCTCGAGGCAGTGAGG
GGGGGCGGGGCGTGGAGATGAAAGGGCCGAGTCTGGGTATTTGGACCGTGATTGTAAAGAAGCTGTTCTAAACCCGTCGGGGGGCGGTGT
TTGCAGGGAGGGAAGTAGCGTGAGGCAGGTTGGGGAAGGCGTGAGAGGCCTAGGAGAGCCGAGGGGCGGTGGAGGGGTGTGGCCTAGAAT
GTTAGGCGGAGCGGGAGGTGGGCCGGGCCTTCGGACGCCCTGTCCCGCAGACGTTGACGAGTGCAGCGAGGAGGACCTTTGCCAGAGCGG
CATCTGTACCAACACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACACCGCGCTGGCCCGGACCTCGCCTCCTGCCTCGACGTGGA
CGAATGTCGCGAGCGAGGCCCAGCCCTGTGCGGGTCGCAGCGCTGTGAGAACTCTCCCGGCTCCTACCGCTGTGTCCGGGACTGCGATCC
TGGGTACCACGCGGGCCCCGAGGGCACCTGTGACGATGTGGACGAATGCCGGAACCGGTCCTTCTGCGGTGCCCACGCCGTGTGCCAGAA
CCTGCCCGGCTCCTTCCAGTGCCTCTGTGACCAGTACGAGGGGGCACGGGATGGGCGTCACTGCGTGGCAACAGCCCGGAAGAGTTTGAC
CCCATGACTGGACGCTGTGTTCCCCCACGAACTTCTGCTGTCTCTGCTGCCCAGCAGCTGGGCTTCCACCTGTGCCTCATGGGCTGGCTG
GCCAATGGCTCCACTGCCCACCCTGTGGTTTTCCCTGTGGCGGACTGTGGCAATGGTCGGGTGGGCATAGTCAGCCTGGGTGCCCGCAAG
AACCTCTCAGAACGCTGGGATGCCTACTGCTTCCGTGTGCAAGATGTGGCCTGCCGATGCCGAAATGGCTTCGTGGGTGACGGGATCAGC
ACGTGCAATGGGAAGCTGCTGGATGTGCTGGCTGCCACTGCCAACTTCTCCACCTTCTATGGGATGCTATTGGGCTATGCCAATGCCACC
CAGCGGGGTCTCGACTTCCTGGACTTCCTGGATGATGAGCTCACGTATAAGACACTCTTCGTCCCTGTCAATGAAGGCTTTGTGGACAAC
ATGACGCTGAGTGGCCCAGACTTGGAGCTGCATGCCTCCAACGCCACCCTCCTAAGTGCCAACGCCAGCCAGGGGAAGTTGCTTCCGGCC
CACTCAGGCCTCAGCCTCATCATCAGTGACGCAGGCCCTGACAACAGTTCCTGGGCCCCTGTGGCCCCAGGGACAGTTGTGGTTAGCCGT
ATCATTGTGTGGGACATCATGGCCTTCAATGGCATCATCCATGCTCTGGCCAGCCCCCTCCTGGCACCCCCACAGCCCCAGGCAGTGCTG
GCGCCTGAAGCCCCACCTGTGGCGGCAGGCGTGGGGGCTGTGCTTGCCGCTGGAGCACTGCTTGGCTTGGTGGCCGGAGCTCTCTACCTC
CGTGCCCGAGGCAAGCCCATGGGCTTTGGCTTCTCTGCCTTCCAGGCGGAAGATGATGCTGATGACGACTTCTCACCGTGGCAAGAAGGG
ACCAACCCCACCCTGGTCTCTGTCCCCAACCCTGTCTTTGGCAGCGACACCTTTTGTGAACCCTTCGATGACTCACTGCTGGAGGAGGAC
TTCCCTGACACCCAGAGGATCCTCACAGTCAAGTGACGAGGCTGGGGCTGAAAGCAGAAGCATGCACAGGGAGGAGACCACTTTTATTGC

>50299_50299_2_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000243562_STAB1_chr3_52556687_ENST00000321725_length(amino acids)=351AA_BP=
MRGNSPEEFDPMTGRCVPPRTSAVSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGIVSLGARKNLSERWDAYCFRVQDVACRC
RNGFVGDGISTCNGKLLDVLAATANFSTFYGMLLGYANATQRGLDFLDFLDDELTYKTLFVPVNEGFVDNMTLSGPDLELHASNATLLSA
NASQGKLLPAHSGLSLIISDAGPDNSSWAPVAPGTVVVSRIIVWDIMAFNGIIHALASPLLAPPQPQAVLAPEAPPVAAGVGAVLAAGAL

--------------------------------------------------------------
>50299_50299_3_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000308370_STAB1_chr3_52556687_ENST00000321725_length(transcript)=4455nt_BP=3330nt
ATGCCGAGGCCTGGCACCAGCGGCCGCCGCCCCCTCCTGCTGGTGCTGTTGCTGCCGCTCTTCGCAGCCGCCACCTCCGCCGCCAGCCCC
AGCCCCAGCCCCAGCCAGGTCGTCGAGGTCCCGGGGGTCCCCAGCCGCCCGGCCAGCGTTGCTGTTTGTCGCTGCTGCCCGGGCCAGACG
TCTAGGAGGAGCCGCTGCATCCGAGCCTTCTGCAGGGTCCGAAGCTGCCAGCCCAAAAAGTGTGCAGGCCCCCAGCGGTGCCTGAACCCA
GTGCCTGCAGTGCCCAGTCCCAGCCCCAGCGTGAGGAAGAGACAGGTGTCCCTCAACTGGCAGCCACTGACGCTCCAGGAGGCCAGAGCT
CTACTGAAGCGGCGGCGGCCCCGGGGGCCAGGGGGCCGGGGACTACTGAGAAGGAGGCCCCCACAGCGTGCCCCCGCTGGCAAGGCCCCG
GTCCTGTGTCCCTTGATCTGTCACAATGGCGGTGTGTGCGTGAAGCCTGACCGCTGCCTCTGTCCCCCGGACTTCGCTGGCAAGTTCTGC
CAGTTGCACTCCTCGGGCGCCCGGCCCCCGGCCCCGGCTGTACCAGGCCTCACCCGCTCCGTGTACACTATGCCACTGGCCAACCACCGC
GACGACGAGCACGGCGTGGCATCTATGGTGAGCGTCCACGTGGAGCACCCGCAGGAGGCGTCGGTGGTGGTGCACCAGGTGGAGCGTGTG
TCTGGCCCTTGGGAGGAGGCGGACGCTGAGGCGGTGGCGCGGGCGGAAGCGGCGGCGCGGGCGGAGGCGGCAGCGCCCTACACGGTGTTG
GCACAGAGCGCGCCGCGGGAGGACGGCTACTCAGATGCCTCGGGCTTCGGTTACTGCTTTCGGGAGCTGCGCGGAGGCGAATGCGCGTCC
CCGCTGCCCGGGCTCCGGACGCAGGAGGTCTGCTGCCGAGGGGCCGGCTTGGCCTGGGGCGTTCACGACTGTCAGCTGTGCTCCGAGCGC
CTGGGGAACTCCGAAAGAGTGAGCGCCCCAGATGGACCTTGTCCAACCGGCTTTGAAAGAGTTAATGGGTCCTGCGAAGATGTGGATGAG
TGCGCGACTGGCGGGCGCTGCCAGCACGGCGAGTGTGCAAACACGCGCGGCGGGTACACGTGTGTGTGCCCCGACGGCTTTCTGCTCGAC
TCGTCCCGCAGCAGCTGCATCTCCCAACACGTGATCTCAGAGGCCAAAGGGCCCTGCTTCCGCGTGCTCCGCGACGGCGGCTGTTCGCTG
CCCATTCTGCGGAACATCACTAAACAGATCTGCTGCTGCAGCCGCGTAGGCAAGGCCTGGGGCCGGGGCTGCCAGCTCTGCCCACCCTTC
GGCTCAGAGGGTTTCCGGGAGATCTGCCCGGCTGGTCCTGGTTACCACTACTCGGCCTCCGACCTCCGCTACAACACCAGACCCCTGGGC
CAGGAGCCACCCCGAGTGTCACTCAGCCAGCCTCGTACCCTGCCAGCCACCTCTCGGCCATCTGCAGGCTTTCTGCCCACCCATCGCCTG
GAGCCCCGGCCTGAACCCCGGCCCGATCCCCGGCCCGGCCCTGAGCTTCCCTTGCCCAGCATCCCTGCCTGGACTGGTCCTGAGATTCCT
GAATCAGGTCCCTCCTCCGGCATGTGTCAGCGCAACCCCCAGGTCTGCGGCCCAGGACGCTGCATTTCCCGGCCCAGCGGCTACACCTGC
GCTTGCGACTCTGGCTTCCGGCTCAGCCCCCAGGGCACCCGATGCATTGATGTGGACGAATGTCGCCGCGTGCCCCCGCCCTGTGCTCCC
GGGCGCTGCGAGAACTCACCAGGCAGCTTCCGCTGCGTGTGCGGCCCGGGCTTCCGAGCCGGCCCACGGGCTGCGGAATGCCTGGATGTG
GACGAGTGCCACCGCGTGCCGCCGCCGTGTGACCTCGGGCGCTGCGAGAACACGCCAGGCAGCTTCCTGTGCGTGTGCCCCGCCGGGTAC
CAGGCTGCACCGCACGGAGCCAGCTGCCAGGATGTGGATGAATGCACCCAGAGCCCAGGCCTGTGTGGCCGAGGGGCCTGCAAGAACCTG
CCTGGCTCTTTCCGCTGTGTTTGCCCGGCTGGCTTCCGGGGCTCGGCGTGTGAAGAGGATGTGGATGAGTGTGCCCAGGAGCCGCCGCCC
TGTGGGCCCGGCCGCTGTGACAACACGGCAGGCTCCTTTCACTGTGCCTGCCCTGCTGGCTTCCGCTCCCGAGGGCCCGGGGCCCCCTGC
CAAGATGTGGATGAGTGTGCCCGAAGCCCCCCACCCTGCACCTACGGCCGGTGTGAGAACACAGAAGGCAGCTTCCAGTGTGTCTGCCCC
ATGGGCTTCCAACCCAACACTGCTGGCTCCGAGTGCGAGGATGTGGATGAGTGTGAGAACCACCTCGCATGCCCTGGGCAGGAGTGTGTG
AACTCGCCCGGCTCCTTCCAGTGCAGGACCTGTCCTTCTGGCCACCACCTGCACCGTGGCAGATGCACTGATGTGGACGAATGCAGTTCG
GGTGCCCCTCCCTGTGGTCCCCACGGCCACTGCACTAACACCGAAGGCTCCTTCCGCTGCAGCTGCGCGCCAGGCTACCGGGCGCCGTCG
GGTCGGCCCGGGCCCTGCGCAGACGTGAACGAGTGCCTGGAGGGCGATTTCTGCTTCCCTCACGGCGAGTGCCTCAACACTGACGGCTCC
TTTGCCTGTACTTGTGCCCCTGGCTACCGACCCGGACCCCGCGGAGCCTCTTGCCTCGACGTTGACGAGTGCAGCGAGGAGGACCTTTGC
CAGAGCGGCATCTGTACCAACACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACACCGCGCTGGCCCGGACCTCGCCTCCTGCCTC
GACGTGGACGAATGTCGCGAGCGAGGCCCAGCCCTGTGCGGGTCGCAGCGCTGTGAGAACTCTCCCGGCTCCTACCGCTGTGTCCGGGAC
TGCGATCCTGGGTACCACGCGGGCCCCGAGGGCACCTGTGACGATGTGGATGAGTGCCAAGAATATGGTCCCGAGATTTGTGGAGCCCAG
CGTTGTGAGAACACCCCTGGCTCCTACCGCTGCACACCAGCCTGTGACCCTGGCTATCAGCCCACGCCAGGGGGCGGATGCCAGGATGTG
GACGAATGCCGGAACCGGTCCTTCTGCGGTGCCCACGCCGTGTGCCAGAACCTGCCCGGCTCCTTCCAGTGCCTCTGTGACCAGTACGAG
GGGGCACGGGATGGGCGTCACTGCGTGGCAACAGCCCGGAAGAGTTTGACCCCATGACTGGACGCTGTGTTCCCCCACGAACTTCTGCTG
TCTCTGCTGCCCAGCAGCTGGGCTTCCACCTGTGCCTCATGGGCTGGCTGGCCAATGGCTCCACTGCCCACCCTGTGGTTTTCCCTGTGG
CGGACTGTGGCAATGGTCGGGTGGGCATAGTCAGCCTGGGTGCCCGCAAGAACCTCTCAGAACGCTGGGATGCCTACTGCTTCCGTGTGC
AAGATGTGGCCTGCCGATGCCGAAATGGCTTCGTGGGTGACGGGATCAGCACGTGCAATGGGAAGCTGCTGGATGTGCTGGCTGCCACTG
CCAACTTCTCCACCTTCTATGGGATGCTATTGGGCTATGCCAATGCCACCCAGCGGGGTCTCGACTTCCTGGACTTCCTGGATGATGAGC
TCACGTATAAGACACTCTTCGTCCCTGTCAATGAAGGCTTTGTGGACAACATGACGCTGAGTGGCCCAGACTTGGAGCTGCATGCCTCCA
ACGCCACCCTCCTAAGTGCCAACGCCAGCCAGGGGAAGTTGCTTCCGGCCCACTCAGGCCTCAGCCTCATCATCAGTGACGCAGGCCCTG
ACAACAGTTCCTGGGCCCCTGTGGCCCCAGGGACAGTTGTGGTTAGCCGTATCATTGTGTGGGACATCATGGCCTTCAATGGCATCATCC
ATGCTCTGGCCAGCCCCCTCCTGGCACCCCCACAGCCCCAGGCAGTGCTGGCGCCTGAAGCCCCACCTGTGGCGGCAGGCGTGGGGGCTG
TGCTTGCCGCTGGAGCACTGCTTGGCTTGGTGGCCGGAGCTCTCTACCTCCGTGCCCGAGGCAAGCCCATGGGCTTTGGCTTCTCTGCCT
TCCAGGCGGAAGATGATGCTGATGACGACTTCTCACCGTGGCAAGAAGGGACCAACCCCACCCTGGTCTCTGTCCCCAACCCTGTCTTTG
GCAGCGACACCTTTTGTGAACCCTTCGATGACTCACTGCTGGAGGAGGACTTCCCTGACACCCAGAGGATCCTCACAGTCAAGTGACGAG
GCTGGGGCTGAAAGCAGAAGCATGCACAGGGAGGAGACCACTTTTATTGCTTGTCTGGGTGGATGGGGCAGGAGGGGCTGAGGGCCTGTC

>50299_50299_3_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000308370_STAB1_chr3_52556687_ENST00000321725_length(amino acids)=1098AA_BP=
MPRPGTSGRRPLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASVAVCRCCPGQTSRRSRCIRAFCRVRSCQPKKCAGPQRCLNP
VPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFC
QLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVL
AQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDE
CATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPF
GSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIP
ESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDV
DECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPP
CGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECV
NSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGS
FACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRD
CDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQYE

--------------------------------------------------------------
>50299_50299_4_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000396819_STAB1_chr3_52556687_ENST00000321725_length(transcript)=4271nt_BP=3146nt
AGCGCGGCGCTGCAGCCATGGCGGGCGGCGTGCGGCTGCTCTGGGTGTCGCTATTGGTGCTGCTGGCGCAGCTAGGGCCGCAGCCTGGAC
TGGGCCGGCTCGGAGAGCGTCTCCGCGTGCGCTTCACCCCGGTCGTGTGCGGCCTGCGCTGCGTCCATGGGCCGACCGGCTCCCGCTGTA
CCCCGACCTGCGCGCCCCGCAACGCCACCAGCGTGGACAGCGGCGCTCCCGGCGGGGCGGCCCCGGGGGGACCCGGCTTCCGCGCCTTCC
TGTGTCCCTTGATCTGTCACAATGGCGGTGTGTGCGTGAAGCCTGACCGCTGCCTCTGTCCCCCGGACTTCGCTGGCAAGTTCTGCCAGT
TGCACTCCTCGGGCGCCCGGCCCCCGGCCCCGGCTGTACCAGGCCTCACCCGCTCCGTGTACACTATGCCACTGGCCAACCACCGCGACG
ACGAGCACGGCGTGGCATCTATGGTGAGCGTCCACGTGGAGCACCCGCAGGAGGCGTCGGTGGTGGTGCACCAGGTGGAGCGTGTGTCTG
GCCCTTGGGAGGAGGCGGACGCTGAGGCGGTGGCGCGGGCGGAAGCGGCGGCGCGGGCGGAGGCGGCAGCGCCCTACACGGTGTTGGCAC
AGAGCGCGCCGCGGGAGGACGGCTACTCAGATGCCTCGGGCTTCGGTTACTGCTTTCGGGAGCTGCGCGGAGGCGAATGCGCGTCCCCGC
TGCCCGGGCTCCGGACGCAGGAGGTCTGCTGCCGAGGGGCCGGCTTGGCCTGGGGCGTTCACGACTGTCAGCTGTGCTCCGAGCGCCTGG
GGAACTCCGAAAGAGTGAGCGCCCCAGATGGACCTTGTCCAACCGGCTTTGAAAGAGTTAATGGGTCCTGCGAAGATGTGGATGAGTGCG
CGACTGGCGGGCGCTGCCAGCACGGCGAGTGTGCAAACACGCGCGGCGGGTACACGTGTGTGTGCCCCGACGGCTTTCTGCTCGACTCGT
CCCGCAGCAGCTGCATCTCCCAACACGTGATCTCAGAGGCCAAAGGGCCCTGCTTCCGCGTGCTCCGCGACGGCGGCTGTTCGCTGCCCA
TTCTGCGGAACATCACTAAACAGATCTGCTGCTGCAGCCGCGTAGGCAAGGCCTGGGGCCGGGGCTGCCAGCTCTGCCCACCCTTCGGCT
CAGAGGGTTTCCGGGAGATCTGCCCGGCTGGTCCTGGTTACCACTACTCGGCCTCCGACCTCCGCTACAACACCAGACCCCTGGGCCAGG
AGCCACCCCGAGTGTCACTCAGCCAGCCTCGTACCCTGCCAGCCACCTCTCGGCCATCTGCAGGCTTTCTGCCCACCCATCGCCTGGAGC
CCCGGCCTGAACCCCGGCCCGATCCCCGGCCCGGCCCTGAGCTTCCCTTGCCCAGCATCCCTGCCTGGACTGGTCCTGAGATTCCTGAAT
CAGGTCCCTCCTCCGGCATGTGTCAGCGCAACCCCCAGGTCTGCGGCCCAGGACGCTGCATTTCCCGGCCCAGCGGCTACACCTGCGCTT
GCGACTCTGGCTTCCGGCTCAGCCCCCAGGGCACCCGATGCATTGATGTGGACGAATGTCGCCGCGTGCCCCCGCCCTGTGCTCCCGGGC
GCTGCGAGAACTCACCAGGCAGCTTCCGCTGCGTGTGCGGCCCGGGCTTCCGAGCCGGCCCACGGGCTGCGGAATGCCTGGATGTGGACG
AGTGCCACCGCGTGCCGCCGCCGTGTGACCTCGGGCGCTGCGAGAACACGCCAGGCAGCTTCCTGTGCGTGTGCCCCGCCGGGTACCAGG
CTGCACCGCACGGAGCCAGCTGCCAGGATGTGGATGAATGCACCCAGAGCCCAGGCCTGTGTGGCCGAGGGGCCTGCAAGAACCTGCCTG
GCTCTTTCCGCTGTGTTTGCCCGGCTGGCTTCCGGGGCTCGGCGTGTGAAGAGGATGTGGATGAGTGTGCCCAGGAGCCGCCGCCCTGTG
GGCCCGGCCGCTGTGACAACACGGCAGGCTCCTTTCACTGTGCCTGCCCTGCTGGCTTCCGCTCCCGAGGGCCCGGGGCCCCCTGCCAAG
ATGTGGATGAGTGTGCCCGAAGCCCCCCACCCTGCACCTACGGCCGGTGTGAGAACACAGAAGGCAGCTTCCAGTGTGTCTGCCCCATGG
GCTTCCAACCCAACACTGCTGGCTCCGAGTGCGAGGATGTGGATGAGTGTGAGAACCACCTCGCATGCCCTGGGCAGGAGTGTGTGAACT
CGCCCGGCTCCTTCCAGTGCAGGACCTGTCCTTCTGGCCACCACCTGCACCGTGGCAGATGCACTGATGTGGACGAATGCAGTTCGGGTG
CCCCTCCCTGTGGTCCCCACGGCCACTGCACTAACACCGAAGGCTCCTTCCGCTGCAGCTGCGCGCCAGGCTACCGGGCGCCGTCGGGTC
GGCCCGGGCCCTGCGCAGACGTGAACGAGTGCCTGGAGGGCGATTTCTGCTTCCCTCACGGCGAGTGCCTCAACACTGACGGCTCCTTTG
CCTGTACTTGTGCCCCTGGCTACCGACCCGGACCCCGCGGAGCCTCTTGCCTCGACGTTGACGAGTGCAGCGAGGAGGACCTTTGCCAGA
GCGGCATCTGTACCAACACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACACCGCGCTGGCCCGGACCTCGCCTCCTGCCTCGACG
TGGACGAATGTCGCGAGCGAGGCCCAGCCCTGTGCGGGTCGCAGCGCTGTGAGAACTCTCCCGGCTCCTACCGCTGTGTCCGGGACTGCG
ATCCTGGGTACCACGCGGGCCCCGAGGGCACCTGTGACGATGTGGATGAGTGCCAAGAATATGGTCCCGAGATTTGTGGAGCCCAGCGTT
GTGAGAACACCCCTGGCTCCTACCGCTGCACACCAGCCTGTGACCCTGGCTATCAGCCCACGCCAGGGGGCGGATGCCAGGATGTGGACG
AATGCCGGAACCGGTCCTTCTGCGGTGCCCACGCCGTGTGCCAGAACCTGCCCGGCTCCTTCCAGTGCCTCTGTGACCAGTACGAGGGGG
CACGGGATGGGCGTCACTGCGTGGCAACAGCCCGGAAGAGTTTGACCCCATGACTGGACGCTGTGTTCCCCCACGAACTTCTGCTGTCTC
TGCTGCCCAGCAGCTGGGCTTCCACCTGTGCCTCATGGGCTGGCTGGCCAATGGCTCCACTGCCCACCCTGTGGTTTTCCCTGTGGCGGA
CTGTGGCAATGGTCGGGTGGGCATAGTCAGCCTGGGTGCCCGCAAGAACCTCTCAGAACGCTGGGATGCCTACTGCTTCCGTGTGCAAGA
TGTGGCCTGCCGATGCCGAAATGGCTTCGTGGGTGACGGGATCAGCACGTGCAATGGGAAGCTGCTGGATGTGCTGGCTGCCACTGCCAA
CTTCTCCACCTTCTATGGGATGCTATTGGGCTATGCCAATGCCACCCAGCGGGGTCTCGACTTCCTGGACTTCCTGGATGATGAGCTCAC
GTATAAGACACTCTTCGTCCCTGTCAATGAAGGCTTTGTGGACAACATGACGCTGAGTGGCCCAGACTTGGAGCTGCATGCCTCCAACGC
CACCCTCCTAAGTGCCAACGCCAGCCAGGGGAAGTTGCTTCCGGCCCACTCAGGCCTCAGCCTCATCATCAGTGACGCAGGCCCTGACAA
CAGTTCCTGGGCCCCTGTGGCCCCAGGGACAGTTGTGGTTAGCCGTATCATTGTGTGGGACATCATGGCCTTCAATGGCATCATCCATGC
TCTGGCCAGCCCCCTCCTGGCACCCCCACAGCCCCAGGCAGTGCTGGCGCCTGAAGCCCCACCTGTGGCGGCAGGCGTGGGGGCTGTGCT
TGCCGCTGGAGCACTGCTTGGCTTGGTGGCCGGAGCTCTCTACCTCCGTGCCCGAGGCAAGCCCATGGGCTTTGGCTTCTCTGCCTTCCA
GGCGGAAGATGATGCTGATGACGACTTCTCACCGTGGCAAGAAGGGACCAACCCCACCCTGGTCTCTGTCCCCAACCCTGTCTTTGGCAG
CGACACCTTTTGTGAACCCTTCGATGACTCACTGCTGGAGGAGGACTTCCCTGACACCCAGAGGATCCTCACAGTCAAGTGACGAGGCTG
GGGCTGAAAGCAGAAGCATGCACAGGGAGGAGACCACTTTTATTGCTTGTCTGGGTGGATGGGGCAGGAGGGGCTGAGGGCCTGTCCCAG

>50299_50299_4_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000396819_STAB1_chr3_52556687_ENST00000321725_length(amino acids)=1031AA_BP=
MAGGVRLLWVSLLVLLAQLGPQPGLGRLGERLRVRFTPVVCGLRCVHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLCPLIC
HNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEA
DAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERV
SAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNIT
KQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPR
PDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSP
GSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV
CPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNT
AGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCA
DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRE
RGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRS

--------------------------------------------------------------
>50299_50299_5_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000545697_STAB1_chr3_52556687_ENST00000321725_length(transcript)=4089nt_BP=2964nt
ATGGGAGACGTAAAAGCGTTGCTGTTTGTCGCTGCTGCCCGGGCCAGACGTCTAGGAGGAGCCGCTGCATCCGAGTCCCTGGCTGTCTCC
GAAGCCTTCTGCAGGGTCCGAAGCTGCCAGCCCAAAAAGTGTGCAGGCCCCCAGCGGTGCCTGAACCCAGTGCCTGCAGTGCCCAGTCCC
AGCCCCAGCGTGAGGAAGAGACAGGTGTCCCTCAACTGGCAGCCACTGACGCTCCAGGAGGCCAGAGCTCTACTGAAGCGGCGGCGGCCC
CGGGGGCCAGGGGGCCGGGGACTACTGAGAAGGAGGCCCCCACAGCGTGCCCCCGCTGGCAAGGCCCCGGTCCTGTGTCCCTTGATCTGT
CACAATGGCGGTGTGTGCGTGAAGCCTGACCGCTGCCTCTGTCCCCCGGACTTCGCTGGCAAGTTCTGCCAGTTGCACTCCTCGGGCGCC
CGGCCCCCGGCCCCGGCTGTACCAGGCCTCACCCGCTCCGTGTACACTATGCCACTGGCCAACCACCGCGACGACGAGCACGGCGTGGCA
TCTATGGTGAGCGTCCACGTGGAGCACCCGCAGGAGGCGTCGGTGGTGGTGCACCAGGTGGAGCGTGTGTCTGGCCCTTGGGAGGAGGCG
GACGCTGAGGCGGTGGCGCGGGCGGAAGCGGCGGCGCGGGCGGAGGCGGCAGCGCCCTACACGGTGTTGGCACAGAGCGCGCCGCGGGAG
GACGGCTACTCAGATGCCTCGGGCTTCGGTTACTGCTTTCGGGAGCTGCGCGGAGGCGAATGCGCGTCCCCGCTGCCCGGGCTCCGGACG
CAGGAGGTCTGCTGCCGAGGGGCCGGCTTGGCCTGGGGCGTTCACGACTGTCAGCTGTGCTCCGAGCGCCTGGGGAACTCCGAAAGAGTG
AGCGCCCCAGATGGACCTTGTCCAACCGGCTTTGAAAGAGTTAATGGGTCCTGCGAAGATGTGGATGAGTGCGCGACTGGCGGGCGCTGC
CAGCACGGCGAGTGTGCAAACACGCGCGGCGGGTACACGTGTGTGTGCCCCGACGGCTTTCTGCTCGACTCGTCCCGCAGCAGCTGCATC
TCCCAACACGTGATCTCAGAGGCCAAAGGGCCCTGCTTCCGCGTGCTCCGCGACGGCGGCTGTTCGCTGCCCATTCTGCGGAACATCACT
AAACAGATCTGCTGCTGCAGCCGCGTAGGCAAGGCCTGGGGCCGGGGCTGCCAGCTCTGCCCACCCTTCGGCTCAGAGGGTTTCCGGGAG
ATCTGCCCGGCTGGTCCTGGTTACCACTACTCGGCCTCCGACCTCCGCTACAACACCAGACCCCTGGGCCAGGAGCCACCCCGAGTGTCA
CTCAGCCAGCCTCGTACCCTGCCAGCCACCTCTCGGCCATCTGCAGGCTTTCTGCCCACCCATCGCCTGGAGCCCCGGCCTGAACCCCGG
CCCGATCCCCGGCCCGGCCCTGAGCTTCCCTTGCCCAGCATCCCTGCCTGGACTGGTCCTGAGATTCCTGAATCAGGTCCCTCCTCCGGC
ATGTGTCAGCGCAACCCCCAGGTCTGCGGCCCAGGACGCTGCATTTCCCGGCCCAGCGGCTACACCTGCGCTTGCGACTCTGGCTTCCGG
CTCAGCCCCCAGGGCACCCGATGCATTGATGTGGACGAATGTCGCCGCGTGCCCCCGCCCTGTGCTCCCGGGCGCTGCGAGAACTCACCA
GGCAGCTTCCGCTGCGTGTGCGGCCCGGGCTTCCGAGCCGGCCCACGGGCTGCGGAATGCCTGGATGTGGACGAGTGCCACCGCGTGCCG
CCGCCGTGTGACCTCGGGCGCTGCGAGAACACGCCAGGCAGCTTCCTGTGCGTGTGCCCCGCCGGGTACCAGGCTGCACCGCACGGAGCC
AGCTGCCAGGATGTGGATGAATGCACCCAGAGCCCAGGCCTGTGTGGCCGAGGGGCCTGCAAGAACCTGCCTGGCTCTTTCCGCTGTGTT
TGCCCGGCTGGCTTCCGGGGCTCGGCGTGTGAAGAGGATGTGGATGAGTGTGCCCAGGAGCCGCCGCCCTGTGGGCCCGGCCGCTGTGAC
AACACGGCAGGCTCCTTTCACTGTGCCTGCCCTGCTGGCTTCCGCTCCCGAGGGCCCGGGGCCCCCTGCCAAGATGTGGATGAGTGTGCC
CGAAGCCCCCCACCCTGCACCTACGGCCGGTGTGAGAACACAGAAGGCAGCTTCCAGTGTGTCTGCCCCATGGGCTTCCAACCCAACACT
GCTGGCTCCGAGTGCGAGGATGTGGATGAGTGTGAGAACCACCTCGCATGCCCTGGGCAGGAGTGTGTGAACTCGCCCGGCTCCTTCCAG
TGCAGGACCTGTCCTTCTGGCCACCACCTGCACCGTGGCAGATGCACTGATGTGGACGAATGCAGTTCGGGTGCCCCTCCCTGTGGTCCC
CACGGCCACTGCACTAACACCGAAGGCTCCTTCCGCTGCAGCTGCGCGCCAGGCTACCGGGCGCCGTCGGGTCGGCCCGGGCCCTGCGCA
GACGTGAACGAGTGCCTGGAGGGCGATTTCTGCTTCCCTCACGGCGAGTGCCTCAACACTGACGGCTCCTTTGCCTGTACTTGTGCCCCT
GGCTACCGACCCGGACCCCGCGGAGCCTCTTGCCTCGACGTTGACGAGTGCAGCGAGGAGGACCTTTGCCAGAGCGGCATCTGTACCAAC
ACCGACGGCTCCTTCGAGTGCATCTGTCCTCCGGGACACCGCGCTGGCCCGGACCTCGCCTCCTGCCTCGACGTGGACGAATGTCGCGAG
CGAGGCCCAGCCCTGTGCGGGTCGCAGCGCTGTGAGAACTCTCCCGGCTCCTACCGCTGTGTCCGGGACTGCGATCCTGGGTACCACGCG
GGCCCCGAGGGCACCTGTGACGCAACAGCCCGGAAGAGTTTGACCCCATGACTGGACGCTGTGTTCCCCCACGAACTTCTGCTGTCTCTG
CTGCCCAGCAGCTGGGCTTCCACCTGTGCCTCATGGGCTGGCTGGCCAATGGCTCCACTGCCCACCCTGTGGTTTTCCCTGTGGCGGACT
GTGGCAATGGTCGGGTGGGCATAGTCAGCCTGGGTGCCCGCAAGAACCTCTCAGAACGCTGGGATGCCTACTGCTTCCGTGTGCAAGATG
TGGCCTGCCGATGCCGAAATGGCTTCGTGGGTGACGGGATCAGCACGTGCAATGGGAAGCTGCTGGATGTGCTGGCTGCCACTGCCAACT
TCTCCACCTTCTATGGGATGCTATTGGGCTATGCCAATGCCACCCAGCGGGGTCTCGACTTCCTGGACTTCCTGGATGATGAGCTCACGT
ATAAGACACTCTTCGTCCCTGTCAATGAAGGCTTTGTGGACAACATGACGCTGAGTGGCCCAGACTTGGAGCTGCATGCCTCCAACGCCA
CCCTCCTAAGTGCCAACGCCAGCCAGGGGAAGTTGCTTCCGGCCCACTCAGGCCTCAGCCTCATCATCAGTGACGCAGGCCCTGACAACA
GTTCCTGGGCCCCTGTGGCCCCAGGGACAGTTGTGGTTAGCCGTATCATTGTGTGGGACATCATGGCCTTCAATGGCATCATCCATGCTC
TGGCCAGCCCCCTCCTGGCACCCCCACAGCCCCAGGCAGTGCTGGCGCCTGAAGCCCCACCTGTGGCGGCAGGCGTGGGGGCTGTGCTTG
CCGCTGGAGCACTGCTTGGCTTGGTGGCCGGAGCTCTCTACCTCCGTGCCCGAGGCAAGCCCATGGGCTTTGGCTTCTCTGCCTTCCAGG
CGGAAGATGATGCTGATGACGACTTCTCACCGTGGCAAGAAGGGACCAACCCCACCCTGGTCTCTGTCCCCAACCCTGTCTTTGGCAGCG
ACACCTTTTGTGAACCCTTCGATGACTCACTGCTGGAGGAGGACTTCCCTGACACCCAGAGGATCCTCACAGTCAAGTGACGAGGCTGGG
GCTGAAAGCAGAAGCATGCACAGGGAGGAGACCACTTTTATTGCTTGTCTGGGTGGATGGGGCAGGAGGGGCTGAGGGCCTGTCCCAGAC

>50299_50299_5_LTBP4-STAB1_LTBP4_chr19_41125336_ENST00000545697_STAB1_chr3_52556687_ENST00000321725_length(amino acids)=976AA_BP=
MGDVKALLFVAAARARRLGGAAASESLAVSEAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRP
RGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVA
SMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRT
QEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI
SQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVS
LSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFR
LSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGA
SCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECA
RSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGP
HGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTN

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Fusion Gene PPI Analysis for LTBP4-STAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LTBP4-STAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LTBP4-STAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource