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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:LTF-CFB (FusionGDB2 ID:50309)

Fusion Gene Summary for LTF-CFB

Fusion gene summary

Fusion gene information	Fusion gene name: LTF-CFB
	Fusion gene ID: 50309
		Hgene	Tgene
	Gene symbol	LTF	CFB
	Gene ID	4057	629
	Gene name	lactotransferrin	complement factor B
	Synonyms	GIG12\|HEL110\|HLF2\|LF	AHUS4\|ARMD14\|BF\|BFD\|CFAB\|CFBD\|FB\|FBI12\|GBG\|H2-Bf\|PBF2
	Cytomap	3p21.31	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	lactotransferrinepididymis luminal protein 110growth-inhibiting protein 12kaliocin-1lactoferricinlactoferroxinneutrophil lactoferrintalalactoferrin	complement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
	Modification date	20200313	20200327
	UniProtAcc	P02788	P00751
	Ensembl transtripts involved in fusion gene	ENST00000426532, ENST00000231751, ENST00000417439, ENST00000493056,	ENST00000375455, ENST00000399981, ENST00000417261, ENST00000419411, ENST00000419920, ENST00000424727, ENST00000425368, ENST00000426239, ENST00000427888, ENST00000433503, ENST00000436692, ENST00000455591, ENST00000456570, ENST00000459734, ENST00000460958, ENST00000465211, ENST00000473139, ENST00000474621, ENST00000477310, ENST00000489605, ENST00000497841, ENST00000556679,
Fusion gene scores	* DoF score	8 X 2 X 5=80	17 X 11 X 9=1683
	# samples	8	20
	** MAII score	log2(8/80*10)=0	log2(20/1683*10)=-3.07296327155522 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LTF [Title/Abstract] AND CFB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	LTF(46477510)-CFB(31913427), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LTF	GO:0001817	regulation of cytokine production	20345905
Hgene	LTF	GO:0002227	innate immune response in mucosa	12037568
Hgene	LTF	GO:0019731	antibacterial humoral response	1599934\|18714013
Hgene	LTF	GO:0019732	antifungal humoral response	11083624
Hgene	LTF	GO:0031640	killing of cells of other organism	9727055
Hgene	LTF	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	20345905
Hgene	LTF	GO:0032680	regulation of tumor necrosis factor production	20345905
Hgene	LTF	GO:0033690	positive regulation of osteoblast proliferation	15166119
Hgene	LTF	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	20345905
Hgene	LTF	GO:0045669	positive regulation of osteoblast differentiation	15166119
Hgene	LTF	GO:0051092	positive regulation of NF-kappaB transcription factor activity	20345905
Hgene	LTF	GO:0060349	bone morphogenesis	15166119
Hgene	LTF	GO:0071902	positive regulation of protein serine/threonine kinase activity	20345905
Hgene	LTF	GO:1900229	negative regulation of single-species biofilm formation in or on host organism	12037568
Hgene	LTF	GO:1902732	positive regulation of chondrocyte proliferation	15166119
Hgene	LTF	GO:2000117	negative regulation of cysteine-type endopeptidase activity	12788072

Fusion gene breakpoints across LTF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CFB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-PE-A5DE-01A	LTF	chr3	46477510	-	CFB	chr6	31913427	+
ChimerDB4	PRAD	TCGA-HC-7079-01A	LTF	chr3	46477510	-	CFB	chr6	31913427	+

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Fusion Gene ORF analysis for LTF-CFB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000426532	ENST00000375455	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000399981	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000417261	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000419411	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000419920	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000424727	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000425368	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000426239	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000427888	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000433503	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000436692	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000455591	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000456570	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000459734	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000460958	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000465211	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000473139	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000474621	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000477310	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000489605	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000497841	LTF	chr3	46477510	-	CFB	chr6	31913427	+
5CDS-intron	ENST00000426532	ENST00000556679	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000375455	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000399981	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000417261	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000419411	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000419920	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000424727	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000425368	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000426239	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000427888	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000433503	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000436692	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000455591	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000456570	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000459734	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000460958	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000465211	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000473139	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000474621	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000477310	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000489605	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000497841	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000231751	ENST00000556679	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000375455	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000399981	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000417261	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000419411	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000419920	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000424727	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000425368	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000426239	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000427888	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000433503	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000436692	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000455591	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000456570	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000459734	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000460958	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000465211	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000473139	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000474621	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000477310	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000489605	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000497841	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000417439	ENST00000556679	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000375455	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000399981	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000417261	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000419411	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000419920	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000424727	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000425368	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000426239	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000427888	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000433503	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000436692	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000455591	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000456570	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000459734	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000460958	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000465211	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000473139	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000474621	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000477310	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000489605	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000497841	LTF	chr3	46477510	-	CFB	chr6	31913427	+
intron-intron	ENST00000493056	ENST00000556679	LTF	chr3	46477510	-	CFB	chr6	31913427	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for LTF-CFB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for LTF-CFB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46477510/:31913427)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LTF P02788	CFB P00751
FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. {ECO:0000269\|PubMed:22900286}.; FUNCTION: [Lactotransferrin]: Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions (PubMed:14573629, PubMed:1599934, PubMed:6802759, PubMed:3169987, PubMed:11179314, PubMed:12693969). Has antimicrobial activity, which depends on the extracellular cation concentration (PubMed:6802759). Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane (PubMed:14573629, PubMed:1599934, PubMed:6802759, PubMed:3169987, PubMed:11179314, PubMed:12693969). Can also prevent bacterial biofilm development in P.aeruginosa infection (PubMed:12037568). Has weak antifungal activity against C.albicans (PubMed:11083624). Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth (PubMed:15166119). Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection (PubMed:17079302). Can inhibit papillomavirus infections (PubMed:17481742). Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling (PubMed:20345905). Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells (PubMed:19033648). Stimulates VEGFA-mediated endothelial cell migration and proliferation (PubMed:16842782). Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs) (PubMed:9359845). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA (PubMed:9359845). {ECO:0000269\|PubMed:11083624, ECO:0000269\|PubMed:11179314, ECO:0000269\|PubMed:12037568, ECO:0000269\|PubMed:12693969, ECO:0000269\|PubMed:14573629, ECO:0000269\|PubMed:15166119, ECO:0000269\|PubMed:1599934, ECO:0000269\|PubMed:16842782, ECO:0000269\|PubMed:17079302, ECO:0000269\|PubMed:17481742, ECO:0000269\|PubMed:19033648, ECO:0000269\|PubMed:20345905, ECO:0000269\|PubMed:3169987, ECO:0000269\|PubMed:6802759, ECO:0000269\|PubMed:9359845}.; FUNCTION: Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection (PubMed:17481742). N-terminal region shows strong antifungal activity against C.albicans (PubMed:11083624). Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site. {ECO:0000269\|PubMed:11083624, ECO:0000269\|PubMed:17481742}.; FUNCTION: [Kaliocin-1]: Has antimicrobial activity and is able to permeabilize different ions through liposomal membranes. {ECO:0000269\|PubMed:12693969}.; FUNCTION: [Lactoferroxin-A]: Has opioid antagonist activity (PubMed:1369293). Shows preference for mu-receptor (PubMed:1369293). {ECO:0000269\|PubMed:1369293}.; FUNCTION: [Lactoferroxin-B]: Has opioid antagonist activity (PubMed:1369293). Shows higher degrees of preference for kappa-receptors than for mu-receptors (PubMed:1369293). {ECO:0000269\|PubMed:1369293}.; FUNCTION: [Lactoferroxin-C]: Has opioid antagonist activity (PubMed:1369293). Shows higher degrees of preference for kappa-receptors than for mu-receptors (PubMed:1369293). {ECO:0000269\|PubMed:1369293}.; FUNCTION: The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions (PubMed:12535064). This function contributes to the antimicrobial activity (PubMed:12535064). Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites (PubMed:12535064). {ECO:0000269\|PubMed:12535064}.; FUNCTION: [Isoform DeltaLf]: transcription factor with antiproliferative properties and ability to induce cell cycle arrest (PubMed:15222485). Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters (PubMed:22320386). {ECO:0000269\|PubMed:15222485, ECO:0000269\|PubMed:22320386}.	FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for LTF-CFB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LTF-CFB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for LTF-CFB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for LTF-CFB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source