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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LUC7L-DOK5 (FusionGDB2 ID:50362)

Fusion Gene Summary for LUC7L-DOK5

check button Fusion gene summary
Fusion gene informationFusion gene name: LUC7L-DOK5
Fusion gene ID: 50362
HgeneTgene
Gene symbol

LUC7L

DOK5

Gene ID

55692

55816

Gene nameLUC7 likedocking protein 5
SynonymsLUC7B1|Luc7|SR+89|hLuc7B1C20orf180|IRS-6|IRS6
Cytomap

16p13.3

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionputative RNA-binding protein Luc7-like 1putative SR protein LUC7B1sarcoplasmic reticulum protein LUC7B1docking protein 5downstream of tyrosine kinase 5insulin receptor substrate 6
Modification date2020032020200320
UniProtAcc

Q9NQ29

Q9P104

Ensembl transtripts involved in fusion geneENST00000293872, ENST00000337351, 
ENST00000397780, ENST00000397783, 
ENST00000494366, 		ENST00000491469, 
ENST00000262593, ENST00000395939, 
Fusion gene scores* DoF score19 X 17 X 10=323011 X 9 X 8=792
# samples 2512
** MAII scorelog2(25/3230*10)=-3.6915341649192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LUC7L [Title/Abstract] AND DOK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLUC7L(242925)-DOK5(53226926), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LUC7L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DOK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1632LUC7Lchr16

242925

-DOK5chr20

53226926

+


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Fusion Gene ORF analysis for LUC7L-DOK5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000293872ENST00000491469LUC7Lchr16

242925

-DOK5chr20

53226926

+
5CDS-intronENST00000337351ENST00000491469LUC7Lchr16

242925

-DOK5chr20

53226926

+
5CDS-intronENST00000397780ENST00000491469LUC7Lchr16

242925

-DOK5chr20

53226926

+
5CDS-intronENST00000397783ENST00000491469LUC7Lchr16

242925

-DOK5chr20

53226926

+
Frame-shiftENST00000397780ENST00000262593LUC7Lchr16

242925

-DOK5chr20

53226926

+
Frame-shiftENST00000397780ENST00000395939LUC7Lchr16

242925

-DOK5chr20

53226926

+
Frame-shiftENST00000397783ENST00000262593LUC7Lchr16

242925

-DOK5chr20

53226926

+
Frame-shiftENST00000397783ENST00000395939LUC7Lchr16

242925

-DOK5chr20

53226926

+
In-frameENST00000293872ENST00000262593LUC7Lchr16

242925

-DOK5chr20

53226926

+
In-frameENST00000293872ENST00000395939LUC7Lchr16

242925

-DOK5chr20

53226926

+
In-frameENST00000337351ENST00000262593LUC7Lchr16

242925

-DOK5chr20

53226926

+
In-frameENST00000337351ENST00000395939LUC7Lchr16

242925

-DOK5chr20

53226926

+
intron-3CDSENST00000494366ENST00000262593LUC7Lchr16

242925

-DOK5chr20

53226926

+
intron-3CDSENST00000494366ENST00000395939LUC7Lchr16

242925

-DOK5chr20

53226926

+
intron-intronENST00000494366ENST00000491469LUC7Lchr16

242925

-DOK5chr20

53226926

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000293872LUC7Lchr16242925-ENST00000262593DOK5chr2053226926+19018871111208365
ENST00000293872LUC7Lchr16242925-ENST00000395939DOK5chr2053226926+16208871111208365
ENST00000337351LUC7Lchr16242925-ENST00000262593DOK5chr2053226926+19149001241221365
ENST00000337351LUC7Lchr16242925-ENST00000395939DOK5chr2053226926+16339001241221365

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000293872ENST00000262593LUC7Lchr16242925-DOK5chr2053226926+0.0009859440.999014
ENST00000293872ENST00000395939LUC7Lchr16242925-DOK5chr2053226926+0.001630290.99836975
ENST00000337351ENST00000262593LUC7Lchr16242925-DOK5chr2053226926+0.0010079850.998992
ENST00000337351ENST00000395939LUC7Lchr16242925-DOK5chr2053226926+0.0016387550.9983613

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Fusion Genomic Features for LUC7L-DOK5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LUC7Lchr16242925-DOK5chr2053226926+1.96E-060.9999981
LUC7Lchr16242925-DOK5chr2053226926+1.96E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LUC7L-DOK5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:242925/chr20:53226926)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LUC7L

Q9NQ29

DOK5

Q9P104

FUNCTION: May bind to RNA via its Arg/Ser-rich domain. {ECO:0000269|PubMed:11170747}.FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLUC7Lchr16:242925chr20:53226926ENST00000293872-710218_259258372.0Coiled coilOntology_term=ECO:0000255
HgeneLUC7Lchr16:242925chr20:53226926ENST00000293872-71087_177258372.0Coiled coilOntology_term=ECO:0000255
HgeneLUC7Lchr16:242925chr20:53226926ENST00000337351-79218_259258326.0Coiled coilOntology_term=ECO:0000255
HgeneLUC7Lchr16:242925chr20:53226926ENST00000337351-7987_177258326.0Coiled coilOntology_term=ECO:0000255
HgeneLUC7Lchr16:242925chr20:53226926ENST00000397783-710218_259258424.0Coiled coilOntology_term=ECO:0000255
HgeneLUC7Lchr16:242925chr20:53226926ENST00000397783-71087_177258424.0Coiled coilOntology_term=ECO:0000255
TgeneDOK5chr16:242925chr20:53226926ENST0000039593948132_23791199.0DomainIRS-type PTB
TgeneDOK5chr16:242925chr20:53226926ENST0000026259348263_273199307.0MotifNote=DKFBH motif
TgeneDOK5chr16:242925chr20:53226926ENST0000039593948263_27391199.0MotifNote=DKFBH motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLUC7Lchr16:242925chr20:53226926ENST00000293872-710243_362258372.0Compositional biasNote=Arg/Ser-rich
HgeneLUC7Lchr16:242925chr20:53226926ENST00000337351-79243_362258326.0Compositional biasNote=Arg/Ser-rich
HgeneLUC7Lchr16:242925chr20:53226926ENST00000397783-710243_362258424.0Compositional biasNote=Arg/Ser-rich
TgeneDOK5chr16:242925chr20:53226926ENST0000026259348132_237199307.0DomainIRS-type PTB
TgeneDOK5chr16:242925chr20:53226926ENST00000262593488_112199307.0DomainNote=PH
TgeneDOK5chr16:242925chr20:53226926ENST00000395939488_11291199.0DomainNote=PH


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Fusion Gene Sequence for LUC7L-DOK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50362_50362_1_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000293872_DOK5_chr20_53226926_ENST00000262593_length(transcript)=1901nt_BP=887nt
GAAAGAGCCGAGTGGGCTCGAGGCCGACGCGACCATCGTTTGTCGACGCCGCTGCCACCGCCTGCCTGAGAGAAGTCGTCGCGGCCGACC
CCGTCGCCTCCGCCGGCTACCATGTCCGCCCAGGCGCAGATGCGGGCCCTGCTGGACCAGCTCATGGGCACGGCTCGGGACGGAGACGAA
ACCAGACAGAGGGTCAAGTTTACAGATGACCGTGTCTGCAAGAGTCACCTTCTGGACTGCTGCCCCCATGACATCCTGGCTGGGACGCGC
ATGGATTTAGGAGAATGTACCAAAATCCACGACTTGGCCCTCCGAGCAGATTATGAGATTGCAAGTAAAGAAAGAGACCTGTTTTTTGAA
TTAGATGCAATGGATCACTTGGAGTCCTTTATTGCTGAATGTGATCGGAGAACTGAGCTCGCCAAGAAGCGGCTGGCAGAAACACAGGAG
GAAATCAGTGCGGAAGTTTCTGCAAAGGCAGAAAAAGTACATGAGTTAAATGAAGAAATAGGAAAACTCCTTGCTAAAGCCGAACAGCTA
GGGGCTGAAGGTAATGTGGATGAATCCCAGAAGATTCTTATGGAAGTGGAAAAAGTTCGTGCGAAGAAAAAAGAAGCTGAGGAAGAATAC
AGAAATTCCATGCCTGCATCCAGTTTTCAGCAGCAAAAGCTGCGTGTCTGCGAGGTCTGTTCAGCCTACCTTGGTCTCCATGACAATGAC
CGTCGCCTGGCAGACCACTTCGGTGGCAAGTTACACTTGGGGTTCATTCAGATCCGAGAGAAGCTTGATCAGTTGAGGAAAACTGTCGCT
GAAAAGCAGGAGAAGAGAAATCAGGATCGCTTGAGGAGGAGAGAGGAGAGGGAACGGGAGGAGCGTCTGAGCAGGAGGATGTGTGAGACT
GGTGAAGGGCTGTTTATCTTTCAGACCCGAGACGGGGAGGCCATCTATCAGAAAGTCCACTCTGCTGCCTTGGCCATAGCCGAGCAGCAC
GAGCGCTTGCTACAGAGTGTGAAAAACTCGATGCTCCAGATGAAGATGAGTGAGCGGGCCGCCTCGCTGAGCACCATGGTGCCCCTGCCT
CGCAGCGCCTACTGGCAGCACATCACACGGCAGCACAGCACGGGACAGCTCTACCGCTTGCAAGATGTTTCCAGCCCTCTGAAGCTTCAT
CGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGATT
CACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAAC
TCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGTT
CCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTGT
CCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTTA
TTTGTTTACACCCTATTCCTCAGTTATTATTACTGTGGTTCTGATTAACTACTGGAAATTATATTTGATTATATCACCAATTAGTTAAAT
CAGTGCTTCGACTCACTCTTATCTGTTCTGTTCAAAACTATTTGTTCAAAGAACCCGTTAGTGTTGTTTACAGGGTTACAGTTTCTCTCA
CATGCTTTCCTCACCCCTTTACCCCCCTTTTTGAAAGCCTTTATTTTGTTCGGAGTCTCTTCATAAAACATTTGAAAATAAAAGATCATT

>50362_50362_1_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000293872_DOK5_chr20_53226926_ENST00000262593_length(amino acids)=365AA_BP=258
MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHL
ESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPAS
SFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRMCETGEGLFIF
QTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPA

--------------------------------------------------------------
>50362_50362_2_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000293872_DOK5_chr20_53226926_ENST00000395939_length(transcript)=1620nt_BP=887nt
GAAAGAGCCGAGTGGGCTCGAGGCCGACGCGACCATCGTTTGTCGACGCCGCTGCCACCGCCTGCCTGAGAGAAGTCGTCGCGGCCGACC
CCGTCGCCTCCGCCGGCTACCATGTCCGCCCAGGCGCAGATGCGGGCCCTGCTGGACCAGCTCATGGGCACGGCTCGGGACGGAGACGAA
ACCAGACAGAGGGTCAAGTTTACAGATGACCGTGTCTGCAAGAGTCACCTTCTGGACTGCTGCCCCCATGACATCCTGGCTGGGACGCGC
ATGGATTTAGGAGAATGTACCAAAATCCACGACTTGGCCCTCCGAGCAGATTATGAGATTGCAAGTAAAGAAAGAGACCTGTTTTTTGAA
TTAGATGCAATGGATCACTTGGAGTCCTTTATTGCTGAATGTGATCGGAGAACTGAGCTCGCCAAGAAGCGGCTGGCAGAAACACAGGAG
GAAATCAGTGCGGAAGTTTCTGCAAAGGCAGAAAAAGTACATGAGTTAAATGAAGAAATAGGAAAACTCCTTGCTAAAGCCGAACAGCTA
GGGGCTGAAGGTAATGTGGATGAATCCCAGAAGATTCTTATGGAAGTGGAAAAAGTTCGTGCGAAGAAAAAAGAAGCTGAGGAAGAATAC
AGAAATTCCATGCCTGCATCCAGTTTTCAGCAGCAAAAGCTGCGTGTCTGCGAGGTCTGTTCAGCCTACCTTGGTCTCCATGACAATGAC
CGTCGCCTGGCAGACCACTTCGGTGGCAAGTTACACTTGGGGTTCATTCAGATCCGAGAGAAGCTTGATCAGTTGAGGAAAACTGTCGCT
GAAAAGCAGGAGAAGAGAAATCAGGATCGCTTGAGGAGGAGAGAGGAGAGGGAACGGGAGGAGCGTCTGAGCAGGAGGATGTGTGAGACT
GGTGAAGGGCTGTTTATCTTTCAGACCCGAGACGGGGAGGCCATCTATCAGAAAGTCCACTCTGCTGCCTTGGCCATAGCCGAGCAGCAC
GAGCGCTTGCTACAGAGTGTGAAAAACTCGATGCTCCAGATGAAGATGAGTGAGCGGGCCGCCTCGCTGAGCACCATGGTGCCCCTGCCT
CGCAGCGCCTACTGGCAGCACATCACACGGCAGCACAGCACGGGACAGCTCTACCGCTTGCAAGATGTTTCCAGCCCTCTGAAGCTTCAT
CGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTGTCAGCCACAGATT
CACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTGGTCATTGGAAAAC
TCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATATTGACTCTGTGTT
CCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACTTCTCTGAATCTGT
CCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTTTAATTATTTGTTA

>50362_50362_2_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000293872_DOK5_chr20_53226926_ENST00000395939_length(amino acids)=365AA_BP=258
MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHL
ESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPAS
SFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRMCETGEGLFIF
QTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPA

--------------------------------------------------------------
>50362_50362_3_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000337351_DOK5_chr20_53226926_ENST00000262593_length(transcript)=1914nt_BP=900nt
TCCCCCGCGGCGGGAAAGAGCCGAGTGGGCTCGAGGCCGACGCGACCATCGTTTGTCGACGCCGCTGCCACCGCCTGCCTGAGAGAAGTC
GTCGCGGCCGACCCCGTCGCCTCCGCCGGCTACCATGTCCGCCCAGGCGCAGATGCGGGCCCTGCTGGACCAGCTCATGGGCACGGCTCG
GGACGGAGACGAAACCAGACAGAGGGTCAAGTTTACAGATGACCGTGTCTGCAAGAGTCACCTTCTGGACTGCTGCCCCCATGACATCCT
GGCTGGGACGCGCATGGATTTAGGAGAATGTACCAAAATCCACGACTTGGCCCTCCGAGCAGATTATGAGATTGCAAGTAAAGAAAGAGA
CCTGTTTTTTGAATTAGATGCAATGGATCACTTGGAGTCCTTTATTGCTGAATGTGATCGGAGAACTGAGCTCGCCAAGAAGCGGCTGGC
AGAAACACAGGAGGAAATCAGTGCGGAAGTTTCTGCAAAGGCAGAAAAAGTACATGAGTTAAATGAAGAAATAGGAAAACTCCTTGCTAA
AGCCGAACAGCTAGGGGCTGAAGGTAATGTGGATGAATCCCAGAAGATTCTTATGGAAGTGGAAAAAGTTCGTGCGAAGAAAAAAGAAGC
TGAGGAAGAATACAGAAATTCCATGCCTGCATCCAGTTTTCAGCAGCAAAAGCTGCGTGTCTGCGAGGTCTGTTCAGCCTACCTTGGTCT
CCATGACAATGACCGTCGCCTGGCAGACCACTTCGGTGGCAAGTTACACTTGGGGTTCATTCAGATCCGAGAGAAGCTTGATCAGTTGAG
GAAAACTGTCGCTGAAAAGCAGGAGAAGAGAAATCAGGATCGCTTGAGGAGGAGAGAGGAGAGGGAACGGGAGGAGCGTCTGAGCAGGAG
GATGTGTGAGACTGGTGAAGGGCTGTTTATCTTTCAGACCCGAGACGGGGAGGCCATCTATCAGAAAGTCCACTCTGCTGCCTTGGCCAT
AGCCGAGCAGCACGAGCGCTTGCTACAGAGTGTGAAAAACTCGATGCTCCAGATGAAGATGAGTGAGCGGGCCGCCTCGCTGAGCACCAT
GGTGCCCCTGCCTCGCAGCGCCTACTGGCAGCACATCACACGGCAGCACAGCACGGGACAGCTCTACCGCTTGCAAGATGTTTCCAGCCC
TCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTG
TCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTG
GTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATA
TTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACT
TCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTT
TAATTATTTGTTATTTGTTTACACCCTATTCCTCAGTTATTATTACTGTGGTTCTGATTAACTACTGGAAATTATATTTGATTATATCAC
CAATTAGTTAAATCAGTGCTTCGACTCACTCTTATCTGTTCTGTTCAAAACTATTTGTTCAAAGAACCCGTTAGTGTTGTTTACAGGGTT
ACAGTTTCTCTCACATGCTTTCCTCACCCCTTTACCCCCCTTTTTGAAAGCCTTTATTTTGTTCGGAGTCTCTTCATAAAACATTTGAAA

>50362_50362_3_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000337351_DOK5_chr20_53226926_ENST00000262593_length(amino acids)=365AA_BP=258
MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHL
ESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPAS
SFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRMCETGEGLFIF
QTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPA

--------------------------------------------------------------
>50362_50362_4_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000337351_DOK5_chr20_53226926_ENST00000395939_length(transcript)=1633nt_BP=900nt
TCCCCCGCGGCGGGAAAGAGCCGAGTGGGCTCGAGGCCGACGCGACCATCGTTTGTCGACGCCGCTGCCACCGCCTGCCTGAGAGAAGTC
GTCGCGGCCGACCCCGTCGCCTCCGCCGGCTACCATGTCCGCCCAGGCGCAGATGCGGGCCCTGCTGGACCAGCTCATGGGCACGGCTCG
GGACGGAGACGAAACCAGACAGAGGGTCAAGTTTACAGATGACCGTGTCTGCAAGAGTCACCTTCTGGACTGCTGCCCCCATGACATCCT
GGCTGGGACGCGCATGGATTTAGGAGAATGTACCAAAATCCACGACTTGGCCCTCCGAGCAGATTATGAGATTGCAAGTAAAGAAAGAGA
CCTGTTTTTTGAATTAGATGCAATGGATCACTTGGAGTCCTTTATTGCTGAATGTGATCGGAGAACTGAGCTCGCCAAGAAGCGGCTGGC
AGAAACACAGGAGGAAATCAGTGCGGAAGTTTCTGCAAAGGCAGAAAAAGTACATGAGTTAAATGAAGAAATAGGAAAACTCCTTGCTAA
AGCCGAACAGCTAGGGGCTGAAGGTAATGTGGATGAATCCCAGAAGATTCTTATGGAAGTGGAAAAAGTTCGTGCGAAGAAAAAAGAAGC
TGAGGAAGAATACAGAAATTCCATGCCTGCATCCAGTTTTCAGCAGCAAAAGCTGCGTGTCTGCGAGGTCTGTTCAGCCTACCTTGGTCT
CCATGACAATGACCGTCGCCTGGCAGACCACTTCGGTGGCAAGTTACACTTGGGGTTCATTCAGATCCGAGAGAAGCTTGATCAGTTGAG
GAAAACTGTCGCTGAAAAGCAGGAGAAGAGAAATCAGGATCGCTTGAGGAGGAGAGAGGAGAGGGAACGGGAGGAGCGTCTGAGCAGGAG
GATGTGTGAGACTGGTGAAGGGCTGTTTATCTTTCAGACCCGAGACGGGGAGGCCATCTATCAGAAAGTCCACTCTGCTGCCTTGGCCAT
AGCCGAGCAGCACGAGCGCTTGCTACAGAGTGTGAAAAACTCGATGCTCCAGATGAAGATGAGTGAGCGGGCCGCCTCGCTGAGCACCAT
GGTGCCCCTGCCTCGCAGCGCCTACTGGCAGCACATCACACGGCAGCACAGCACGGGACAGCTCTACCGCTTGCAAGATGTTTCCAGCCC
TCTGAAGCTTCATCGAACAGAGACTTTTCCAGCCTACAGATCTGAGCACTGACAGTAACTGCCAAGAATTGTTAACACACTTGTGATGTG
TCAGCCACAGATTCACCCAGGAGGTCACAGAATGACAGCAAGGGAAATGACGACCAAGAGAAGAAGCTTAAAGTCCTGGCTAATTGTGTG
GTCATTGGAAAACTCTGCAATACAATAATTTTCTTTATTTTCTTTTTCTTTTTTAAATTCTTAGTGTAATTGAAACGTGCTCTATAGATA
TTGACTCTGTGTTCCCTCTTTTACAGCTGGACAGAAAGAAGTCAATGTCACGAAATGATTTTCTATTGTAGATACTTTGTCCCTTGCACT
TCTCTGAATCTGTCCTTTTGTGGATTCTTGTGATTTTCCTTCCAAGTGTTTCAGTTGTATGACAGTCAGTATTGACAATAAAATGGCTTT

>50362_50362_4_LUC7L-DOK5_LUC7L_chr16_242925_ENST00000337351_DOK5_chr20_53226926_ENST00000395939_length(amino acids)=365AA_BP=258
MSAQAQMRALLDQLMGTARDGDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAMDHL
ESFIAECDRRTELAKKRLAETQEEISAEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPAS
SFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDRLRRREEREREERLSRRMCETGEGLFIF
QTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPA

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Fusion Gene PPI Analysis for LUC7L-DOK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LUC7L-DOK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LUC7L-DOK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource