FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LUZP1-NEDD4L (FusionGDB2 ID:50393)

Fusion Gene Summary for LUZP1-NEDD4L

check button Fusion gene summary
Fusion gene informationFusion gene name: LUZP1-NEDD4L
Fusion gene ID: 50393
HgeneTgene
Gene symbol

LUZP1

NEDD4L

Gene ID

7798

23327

Gene nameleucine zipper protein 1NEDD4 like E3 ubiquitin protein ligase
SynonymsLUZPNEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2
Cytomap

1p36.12

18q21.31

Type of geneprotein-codingprotein-coding
Descriptionleucine zipper protein 1E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5
Modification date2020031320200329
UniProtAcc.

Q96PU5

Ensembl transtripts involved in fusion geneENST00000302291, ENST00000314174, 
ENST00000374623, ENST00000418342, 
ENST00000256830, ENST00000256832, 
ENST00000357895, ENST00000382850, 
ENST00000431212, ENST00000435432, 
ENST00000456173, ENST00000456986, 
ENST00000586263, ENST00000588516, 
ENST00000589054, ENST00000356462, 
ENST00000400345, 
Fusion gene scores* DoF score8 X 6 X 5=24027 X 28 X 6=4536
# samples 1032
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/4536*10)=-3.82527683005487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LUZP1 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLUZP1(23417683)-NEDD4L(55919233), # samples:2
Anticipated loss of major functional domain due to fusion event.LUZP1-NEDD4L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LUZP1-NEDD4L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LUZP1-NEDD4L seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

TgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0010038

response to metal ion

11244092

TgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

TgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

TgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

TgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

TgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

TgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

TgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

TgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

TgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

TgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

TgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check buttonFusion gene breakpoints across LUZP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NEDD4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A0YO-01ALUZP1chr1

23417683

-NEDD4Lchr18

55919233

+


Top

Fusion Gene ORF analysis for LUZP1-NEDD4L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000302291ENST00000256830LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000256832LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000357895LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000382850LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000431212LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000435432LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000456173LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000456986LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000302291ENST00000586263LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000256830LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000256832LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000357895LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000382850LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000431212LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000435432LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000456173LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000456986LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000314174ENST00000586263LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000256830LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000256832LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000357895LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000382850LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000431212LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000435432LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000456173LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000456986LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000374623ENST00000586263LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000256830LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000256832LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000357895LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000382850LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000431212LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000435432LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000456173LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000456986LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-5UTRENST00000418342ENST00000586263LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000302291ENST00000588516LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000302291ENST00000589054LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000314174ENST00000588516LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000314174ENST00000589054LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000374623ENST00000588516LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000374623ENST00000589054LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000418342ENST00000588516LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
5CDS-intronENST00000418342ENST00000589054LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
Frame-shiftENST00000302291ENST00000356462LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
Frame-shiftENST00000302291ENST00000400345LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
Frame-shiftENST00000374623ENST00000356462LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
Frame-shiftENST00000374623ENST00000400345LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
Frame-shiftENST00000418342ENST00000356462LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
Frame-shiftENST00000418342ENST00000400345LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
In-frameENST00000314174ENST00000356462LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+
In-frameENST00000314174ENST00000400345LUZP1chr1

23417683

-NEDD4Lchr18

55919233

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314174LUZP1chr123417683-ENST00000356462NEDD4Lchr1855919233+6041324313257351867
ENST00000314174LUZP1chr123417683-ENST00000400345NEDD4Lchr1855919233+6364324313259271931

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314174ENST00000356462LUZP1chr123417683-NEDD4Lchr1855919233+0.001655040.998345
ENST00000314174ENST00000400345LUZP1chr123417683-NEDD4Lchr1855919233+0.0009853180.9990146

Top

Fusion Genomic Features for LUZP1-NEDD4L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LUZP1chr123417682-NEDD4Lchr1855919232+0.001266350.9987337
LUZP1chr123417682-NEDD4Lchr1855919232+0.001266350.9987337

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for LUZP1-NEDD4L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:23417683/chr18:55919233)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NEDD4L

Q96PU5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). {ECO:0000250|UniProtKB:Q8CFI0, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15217910, ECO:0000269|PubMed:15489223, ECO:0000269|PubMed:15496141, ECO:0000269|PubMed:15576372, ECO:0000269|PubMed:19144635, ECO:0000269|PubMed:23999003, ECO:0000269|PubMed:25631046, ECO:0000269|PubMed:26363003, ECO:0000269|PubMed:27445338, ECO:0000269|PubMed:27694961}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLUZP1chr1:23417683chr18:55919233ENST00000302291-4511_35910241077.0Coiled coilOntology_term=ECO:0000255
HgeneLUZP1chr1:23417683chr18:55919233ENST00000314174-2311_35910241027.0Coiled coilOntology_term=ECO:0000255
HgeneLUZP1chr1:23417683chr18:55919233ENST00000374623-2311_35910241077.0Coiled coilOntology_term=ECO:0000255
HgeneLUZP1chr1:23417683chr18:55919233ENST00000418342-3411_35910241077.0Coiled coilOntology_term=ECO:0000255
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000256830328193_22681872.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000256830328385_41881872.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000256830328497_53081872.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000256830328548_58181872.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000256830328640_97481872.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000356462329193_22681912.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000356462329385_41881912.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000356462329497_53081912.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000356462329548_58181912.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000356462329640_97481912.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000357895331193_22673968.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000357895331385_41873968.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000357895331497_53073968.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000357895331548_58173968.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000357895331640_97473968.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000382850330193_22681956.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000382850330385_41881956.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000382850330497_53081956.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000382850330548_58181956.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000382850330640_97481956.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000400345331193_22681976.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000400345331385_41881976.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000400345331497_53081976.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000400345331548_58181976.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000400345331640_97481976.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000431212230193_2260855.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000431212230385_4180855.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000431212230497_5300855.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000004312122304_1260855.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000431212230548_5810855.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000431212230640_9740855.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000435432431193_2260835.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000435432431385_4180835.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000435432431497_5300835.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000004354324314_1260835.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000435432431548_5810835.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000435432431640_9740835.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456173229193_2260835.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456173229385_4180835.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456173229497_5300835.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000004561732294_1260835.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456173229548_5810835.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456173229640_9740835.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456986331193_2260855.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456986331385_4180855.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456986331497_5300855.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000004569863314_1260855.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456986331548_5810855.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000456986331640_9740855.0DomainHECT
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000586263330193_22673948.0DomainWW 1
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000586263330385_41873948.0DomainWW 2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000586263330497_53073948.0DomainWW 3
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000586263330548_58173948.0DomainWW 4
TgeneNEDD4Lchr1:23417683chr18:55919233ENST00000586263330640_97473948.0DomainHECT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000002568303284_12681872.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000003564623294_12681912.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000003578953314_12673968.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000003828503304_12681956.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000004003453314_12681976.0DomainC2
TgeneNEDD4Lchr1:23417683chr18:55919233ENST000005862633304_12673948.0DomainC2


Top

Fusion Gene Sequence for LUZP1-NEDD4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50393_50393_1_LUZP1-NEDD4L_LUZP1_chr1_23417683_ENST00000314174_NEDD4L_chr18_55919233_ENST00000356462_length(transcript)=6041nt_BP=3243nt
AGCTGAGCGGCGGAACCCTTCGCTGGCGGGAGCGCGGTTCGGGGCCGCAGAGATTGATGATGGTCTCCAGCTGTCAAAGAAGATTGTGGT
TGCCAAGAGAAAGGTAACCATTTCTCATCCCCTTGAGTGGAATTGGATGCCTCTAGGAGCCCACATTGGCTGGCAGTAGACATGGCCGAA
TTTACAAGCTACAAGGAGACGGCCTCCAGCCGCCACTTGCGGTTTAAGCTACAGAGTCTAAGCCGCCGCCTTGATGAGTTGGAGGAAGCC
ACAAAAAACCTCCAGAAAGCAGAGGATGAACTCCTGGATCTCCAGGACAAGGTGATTCAGGCAGAAGGTAGCAACTCCAGCATGTTGGCG
GAGATTGAAGTGCTGCGCCAGCGGGTGCTGAGAATTGAAGGCAAAGACGAGGAAATTAAGAGAGCAGAGGATCTGTGTCGTCTGATGAAG
GAGAAACTTGAAGAGGAAGAAAACCTCACCCGGGAGCTGAAATCTGAGATTGAGCGGCTTCAGAAACGAATGGCTGAATTAGAGAAGCTA
GAAGAGGCCTTCAGCAGGAGTAAGAATGACTGTACCCAGCTGTGTCTGAGCCTGAATGAGGAGAGAAATCTGACCAAGAAAATCTCCTCT
GAGCTGGAAATGCTCAGAGTCAAAGTGAAAGAACTAGAATCTTCTGAGGACCGCCTGGATAAAACTGAGCAGAGTTTAGCGTCAGAGTTA
GAAAAGCTGAAATCATTAACTCTGAGCTTTGTAAGTGAGAGAAAATACTTGAATGAAAAGGAGAAAGAAAATGAGAAATTGATAAAAGAA
CTCACTCAAAAACTAGAGCAGAACAAAAAAATGAACCGAGATTATACAAGGAATGCTTCTAATCTGGAAAGAAATGACCTACGGATTGAG
GATGGCATCTCTTCCACACTGCCGTCCAAAGAATCAAGAAGGAAGGGTGGTCTGGACTACCTAAAGCAGGTAGAGAATGAAACAAGAAAC
AAATCAGAAAATGAAAAGAACCGCAATCAGGAAGACAACAAAGTCAAAGACCTTAACCAAGAGATTGAGAAACTTAAGACACAAATCAAA
CACTTTGAATCGTTGGAAGAAGAGCTTAAGAAAATGAAGTCCAAAAATAACGACCTTCAGGATAATTACCTAAGTGAACAAAATAAAAAC
AAATTATTAGCCAGCCAACTGGAGGAGATAAAGCTACAAATCAAGAAACAGAAAGAGTTAGAAAATGGAGAGGTAGAAGGGGAAGATGCT
TTCCTGTCCAGCAAAGGCAGACATGAGAGGACTAAGTTTAGAGGCCACGGAAGTGAAGCTTCTGTGTCCAAGCACACAGCGCGGGAACTG
TCTCCTCAGCATAAGCGGGAACGACTCCGGAACAGGGAGTTTGCTCTCAACAATGAAAACTATTCTCTGAGCAACAGGCAGGTTTCTTCT
CCCAGTTTCACCAACAGGAGGGCAGCAAAAGCTTCTCACATGGGGGTGAGTACAGACAGTGGGACTCAGGAGACAAAGAAAACTGAAGAC
CGGTTTGTACCCGGCTCCTCCCAGAGCGAAGGGAAGAAGTCTAGGGAGCAGCCCTCAGTGCTGAGTCGCTACCCCCCGGCTGCTCAGGAG
CACAGTAAAGCGTGGAAGGGGACTTCCAAGCCAGGCACCGAGAGCGGACTGAAGGGAAAAGTGGAGAAGACAACACGAACGTTTAGTGAC
ACCACCCATGGATCTGTTCCCAGTGACCCATTGGGTAGAGCTGACAAGGCTTCTGACACCTCCTCTGAGACTGTCTTTGGCAAGAGGGGA
CACGTGCTTGGCAACGGAAGTCAAGTAACTCAGGCTGCAAACTCTGGCTGTTCTAAGGCCATTGGAGCCCTGGCCTCATCTCGAAGATCC
TCCTCAGAAGGGCTCTCTAAAGGCAAAAAGGCTGCCAATGGCCTTGAGGCTGATAACAGTTGCCCGAATTCCAAGGCTCCTGTTCTATCG
AAGTATCCTTATAGCTGTAGAAGCCAAGAGAACATCCTTCAGGGATTTTCAACCTCACATAAAGAAGGGGTTAATCAACCTGCAGCAGTT
GTGATGGAAGACAGCAGTCCGCATGAAGCCTTGAGGTGTCGAGTCATCAAATCCAGTGGCAGAGAGAAGCCAGACTCAGATGATGACTTG
GACATAGCATCTCTTGTTACTGCCAAGTTGGTAAATACAACCATCACTCCAGAGCCAGAGCCCAAACCACAGCCTAACTCTAGAGAAAAG
GCTAAAACCCGAGGGGCACCTAGAACCTCCCTATTTGAGAATGATAAAGATGCTGGAATGGAGAATGAATCTGTGAAATCTGTCAGAGCC
TCCACCAATACCATGGAGCTCCCAGATACCAATGGTGCTGGGGTAAAAAGCCAAAGGCCCTTTAGCCCCAGAGAGGCGTTGCGGTCTAGA
GCCATCATCAAACCTGTTATTGTTGATAAGGATGTGAAAAAAATCATGGGAGGATCTGGAACAGAGACTACGTTGGAGAAACAGAAACCC
GTCTCCAAACCAGGGCCAAACAAAGTGACAAGTAGCATTACTATATATCCATCTGACAGCAGCAGCCCCAGAGCTGCTCCGGGTGAGGCC
CTGAGGGAGAGGCACACATCCACTAGCAATATCCAGGTGGGGCTGGCAGAGCTCACATCAGTTAGCAACCATGTCAGCTCCCCTTTTGAG
CTCTCCATTCACAAACATGACATCACCCTGCAGCTTGCAGAAGCGGAGAGAATGGCAGATGGGCCCCTGAAGGACAGGCCAGAAACAGTG
GTCTCTCGGAGCAGCATTATAATCAAGCCATCGGATCCTGTGGAGAGGAATAGCCATGCACCTCCAGCGGAGACAATCAGGTGGAAAAGC
CATAGTGCCCCTTCAGAAGTGGGCTTCTCAGATGCCAGACATGTTACTGTGCGGAATGCCTGGAAGAGTAGGCGAGACTTGAAATCTTTA
GAAGACCCCCCAACTCGAATAGGTAAAAACGTGGAATCTACCAATAGCAATGCCTACACCCAGAGGTCTTCCACAGACTTCTCAGAACTC
GAACAGCCCAGGTCCTGCCTTTTTGAGCAGGGCACTCGAAGGGTAGGACCAAGTTCAGGGGATGCCCCTGAGCCCTCCTCCAGAAGGACC
CAAAGTAGCCTCACTGTGTCAGAGGTGCTTACCCGTCGGAATCGGGTAGGAGACACCATCACTGTCGCAGCCTGGAACCACTCAGCAAGC
ATGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTG
CCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCT
CGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATG
GAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAA
GAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCC
TCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAG
CCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCT
CTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGAC
TCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAG
GGCCATCTACCACCGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAGATCCGCCGGCCT
CGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTGAAAGACACCCTT
TCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCACCCGGCTGGGAA
ATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTGAAATTTCCAGTA
CATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTGGATGGCCGAACG
TTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCTGTCCCTTACTCC
AGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATGAAACTTCACAGA
AATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATTGAGTTTGAATCA
GAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTACGGCCTCTTTGAG
TACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTCTGTAATGAGGATCATTTGTCCTACTTCACTTTTATTGGA
AGAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTTTACAAGATGATGTTGGGAAAGCAGATA
ACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGGATCCTGGAGAATGACCCTACTGAGCTGGACCTCATG
TTCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAAATAATGGTCACAAATGAAAACAAA
AGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAGAAGCAGATGAACGCCTTCTTGGAGGGATTCACAGAACTA
CTTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTCGGTGATGTGGATGTGAATGACTGGAGA
CAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGGTTCTGGAAGGCTGTGCTACTCATGGACGCCGAAAAG
CGTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTTTATGGTTCCAATGGTCCTCAGCTG
TTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACATGCTTTAATCGCCTTGACTTACCTCCATATGAAACCTTT
GAAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGATTAAGCACCCTGTGCCTCGGGGGTGGTT
GTTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCAGAGGCGATGGCAGAGAGCAGCTGCAGGCATGGTCCC
TGGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTCCCAGCTTGAGTTCCTGCCTTTCCCACCACAAATTAT
CAACTGGTTGATGTGTACACTAATTACATTTCAGGAGGACTTAATGCTATTTATGTTGTGCCTCTGCAGGCAAAGCCCTTAATAAATATT

>50393_50393_1_LUZP1-NEDD4L_LUZP1_chr1_23417683_ENST00000314174_NEDD4L_chr18_55919233_ENST00000356462_length(amino acids)=1867AA_BP=1037
MDASRSPHWLAVDMAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEG
KDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELES
SEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR
KGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI
KKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHM
GVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRA
DKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQ
GFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFEN
DKDAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEKQKPVSKPGPNKVTSSIT
IYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSSPFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPV
ERNSHAPPAETIRWKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELEQPRSCLFEQGTRR
VGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNHSASMVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMER
PYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNH
NNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSP
QELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPL
EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLG
PLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSV
KRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLD
GFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVN
RVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRV

--------------------------------------------------------------
>50393_50393_2_LUZP1-NEDD4L_LUZP1_chr1_23417683_ENST00000314174_NEDD4L_chr18_55919233_ENST00000400345_length(transcript)=6364nt_BP=3243nt
AGCTGAGCGGCGGAACCCTTCGCTGGCGGGAGCGCGGTTCGGGGCCGCAGAGATTGATGATGGTCTCCAGCTGTCAAAGAAGATTGTGGT
TGCCAAGAGAAAGGTAACCATTTCTCATCCCCTTGAGTGGAATTGGATGCCTCTAGGAGCCCACATTGGCTGGCAGTAGACATGGCCGAA
TTTACAAGCTACAAGGAGACGGCCTCCAGCCGCCACTTGCGGTTTAAGCTACAGAGTCTAAGCCGCCGCCTTGATGAGTTGGAGGAAGCC
ACAAAAAACCTCCAGAAAGCAGAGGATGAACTCCTGGATCTCCAGGACAAGGTGATTCAGGCAGAAGGTAGCAACTCCAGCATGTTGGCG
GAGATTGAAGTGCTGCGCCAGCGGGTGCTGAGAATTGAAGGCAAAGACGAGGAAATTAAGAGAGCAGAGGATCTGTGTCGTCTGATGAAG
GAGAAACTTGAAGAGGAAGAAAACCTCACCCGGGAGCTGAAATCTGAGATTGAGCGGCTTCAGAAACGAATGGCTGAATTAGAGAAGCTA
GAAGAGGCCTTCAGCAGGAGTAAGAATGACTGTACCCAGCTGTGTCTGAGCCTGAATGAGGAGAGAAATCTGACCAAGAAAATCTCCTCT
GAGCTGGAAATGCTCAGAGTCAAAGTGAAAGAACTAGAATCTTCTGAGGACCGCCTGGATAAAACTGAGCAGAGTTTAGCGTCAGAGTTA
GAAAAGCTGAAATCATTAACTCTGAGCTTTGTAAGTGAGAGAAAATACTTGAATGAAAAGGAGAAAGAAAATGAGAAATTGATAAAAGAA
CTCACTCAAAAACTAGAGCAGAACAAAAAAATGAACCGAGATTATACAAGGAATGCTTCTAATCTGGAAAGAAATGACCTACGGATTGAG
GATGGCATCTCTTCCACACTGCCGTCCAAAGAATCAAGAAGGAAGGGTGGTCTGGACTACCTAAAGCAGGTAGAGAATGAAACAAGAAAC
AAATCAGAAAATGAAAAGAACCGCAATCAGGAAGACAACAAAGTCAAAGACCTTAACCAAGAGATTGAGAAACTTAAGACACAAATCAAA
CACTTTGAATCGTTGGAAGAAGAGCTTAAGAAAATGAAGTCCAAAAATAACGACCTTCAGGATAATTACCTAAGTGAACAAAATAAAAAC
AAATTATTAGCCAGCCAACTGGAGGAGATAAAGCTACAAATCAAGAAACAGAAAGAGTTAGAAAATGGAGAGGTAGAAGGGGAAGATGCT
TTCCTGTCCAGCAAAGGCAGACATGAGAGGACTAAGTTTAGAGGCCACGGAAGTGAAGCTTCTGTGTCCAAGCACACAGCGCGGGAACTG
TCTCCTCAGCATAAGCGGGAACGACTCCGGAACAGGGAGTTTGCTCTCAACAATGAAAACTATTCTCTGAGCAACAGGCAGGTTTCTTCT
CCCAGTTTCACCAACAGGAGGGCAGCAAAAGCTTCTCACATGGGGGTGAGTACAGACAGTGGGACTCAGGAGACAAAGAAAACTGAAGAC
CGGTTTGTACCCGGCTCCTCCCAGAGCGAAGGGAAGAAGTCTAGGGAGCAGCCCTCAGTGCTGAGTCGCTACCCCCCGGCTGCTCAGGAG
CACAGTAAAGCGTGGAAGGGGACTTCCAAGCCAGGCACCGAGAGCGGACTGAAGGGAAAAGTGGAGAAGACAACACGAACGTTTAGTGAC
ACCACCCATGGATCTGTTCCCAGTGACCCATTGGGTAGAGCTGACAAGGCTTCTGACACCTCCTCTGAGACTGTCTTTGGCAAGAGGGGA
CACGTGCTTGGCAACGGAAGTCAAGTAACTCAGGCTGCAAACTCTGGCTGTTCTAAGGCCATTGGAGCCCTGGCCTCATCTCGAAGATCC
TCCTCAGAAGGGCTCTCTAAAGGCAAAAAGGCTGCCAATGGCCTTGAGGCTGATAACAGTTGCCCGAATTCCAAGGCTCCTGTTCTATCG
AAGTATCCTTATAGCTGTAGAAGCCAAGAGAACATCCTTCAGGGATTTTCAACCTCACATAAAGAAGGGGTTAATCAACCTGCAGCAGTT
GTGATGGAAGACAGCAGTCCGCATGAAGCCTTGAGGTGTCGAGTCATCAAATCCAGTGGCAGAGAGAAGCCAGACTCAGATGATGACTTG
GACATAGCATCTCTTGTTACTGCCAAGTTGGTAAATACAACCATCACTCCAGAGCCAGAGCCCAAACCACAGCCTAACTCTAGAGAAAAG
GCTAAAACCCGAGGGGCACCTAGAACCTCCCTATTTGAGAATGATAAAGATGCTGGAATGGAGAATGAATCTGTGAAATCTGTCAGAGCC
TCCACCAATACCATGGAGCTCCCAGATACCAATGGTGCTGGGGTAAAAAGCCAAAGGCCCTTTAGCCCCAGAGAGGCGTTGCGGTCTAGA
GCCATCATCAAACCTGTTATTGTTGATAAGGATGTGAAAAAAATCATGGGAGGATCTGGAACAGAGACTACGTTGGAGAAACAGAAACCC
GTCTCCAAACCAGGGCCAAACAAAGTGACAAGTAGCATTACTATATATCCATCTGACAGCAGCAGCCCCAGAGCTGCTCCGGGTGAGGCC
CTGAGGGAGAGGCACACATCCACTAGCAATATCCAGGTGGGGCTGGCAGAGCTCACATCAGTTAGCAACCATGTCAGCTCCCCTTTTGAG
CTCTCCATTCACAAACATGACATCACCCTGCAGCTTGCAGAAGCGGAGAGAATGGCAGATGGGCCCCTGAAGGACAGGCCAGAAACAGTG
GTCTCTCGGAGCAGCATTATAATCAAGCCATCGGATCCTGTGGAGAGGAATAGCCATGCACCTCCAGCGGAGACAATCAGGTGGAAAAGC
CATAGTGCCCCTTCAGAAGTGGGCTTCTCAGATGCCAGACATGTTACTGTGCGGAATGCCTGGAAGAGTAGGCGAGACTTGAAATCTTTA
GAAGACCCCCCAACTCGAATAGGTAAAAACGTGGAATCTACCAATAGCAATGCCTACACCCAGAGGTCTTCCACAGACTTCTCAGAACTC
GAACAGCCCAGGTCCTGCCTTTTTGAGCAGGGCACTCGAAGGGTAGGACCAAGTTCAGGGGATGCCCCTGAGCCCTCCTCCAGAAGGACC
CAAAGTAGCCTCACTGTGTCAGAGGTGCTTACCCGTCGGAATCGGGTAGGAGACACCATCACTGTCGCAGCCTGGAACCACTCAGCAAGC
ATGGTAAACCCATCTAATCACAGACTCCTATTTGAAGTATTTGACGAAAATAGACTGACACGAGACGACTTCCTGGGCCAGGTGGACGTG
CCCCTTAGTCACCTTCCGACAGAAGATCCAACCATGGAGCGACCCTATACATTTAAGGACTTTCTCCTCAGACCAAGAAGTCATAAGTCT
CGAGTTAAGGGATTTTTGCGATTGAAAATGGCCTATATGCCAAAAAATGGAGGTCAAGATGAAGAAAACAGTGACCAGAGGGATGACATG
GAGCATGGATGGGAAGTTGTTGACTCAAATGACTCGGCTTCTCAGCACCAAGAGGAACTTCCTCCTCCTCCTCTGCCTCCCGGGTGGGAA
GAAAAAGTGGACAATTTAGGCCGAACTTACTATGTCAACCACAACAACCGGACCACTCAGTGGCACAGACCAAGCCTGATGGACGTGTCC
TCGGAGTCGGACAATAACATCAGACAGATCAACCAGGAGGCAGCACACCGGCGCTTCCGCTCCCGCAGGCACATCAGCGAAGACTTGGAG
CCCGAGCCCTCGGAGGGCGGGGATGTCCCCGAGCCTTGGGAGACCATTTCAGAGGAAGTGAATATCGCTGGAGACTCTCTCGGTCTGGCT
CTGCCCCCACCACCGGCCTCCCCAGGATCTCGGACCAGCCCTCAGGAGCTGTCAGAGGAACTAAGCAGAAGGCTTCAGATCACTCCAGAC
TCCAATGGGGAACAGTTCAGCTCTTTGATTCAAAGAGAACCCTCCTCAAGGTTGAGGTCATGCAGTGTCACCGACGCAGTTGCAGAACAG
GGCCATCTACCACCGCCCAGTGCCCCAGCTGGGAGAGCGCGTTCATCAACTGTCACGGGTGGTGAGGAACCAACGCCATCAGTGGCCTAT
GTACATACCACGCCGGGTCTGCCTTCAGGCTGGGAAGAAAGAAAAGATGCTAAGGGGCGCACATACTATGTCAATCATAACAATCGAACC
ACAACTTGGACTCGACCTATCATGCAGCTTGCAGAAGATGGTGCGTCCGGATCAGCCACAAACAGTAACAACCATCTAATCGAGCCTCAG
ATCCGCCGGCCTCGTAGCCTCAGCTCGCCAACAGTAACTTTATCTGCCCCGCTGGAGGGTGCCAAGGACTCACCCGTACGTCGGGCTGTG
AAAGACACCCTTTCCAACCCACAGTCCCCACAGCCATCACCTTACAACTCCCCCAAACCACAACACAAAGTCACACAGAGCTTCTTGCCA
CCCGGCTGGGAAATGAGGATAGCGCCAAACGGCCGGCCCTTCTTCATTGATCATAACACAAAGACTACAACCTGGGAAGATCCACGTTTG
AAATTTCCAGTACATATGCGGTCAAAGACATCTTTAAACCCCAATGACCTTGGCCCCCTTCCTCCTGGCTGGGAAGAAAGAATTCACTTG
GATGGCCGAACGTTTTATATTGATCATAATAGCAAAATTACTCAGTGGGAAGACCCAAGACTGCAGAACCCAGCTATTACTGGTCCGGCT
GTCCCTTACTCCAGAGAATTTAAGCAGAAATATGACTACTTCAGGAAGAAATTAAAGAAACCTGCTGATATCCCCAATAGGTTTGAAATG
AAACTTCACAGAAATAACATATTTGAAGAGTCCTATCGGAGAATTATGTCCGTGAAAAGACCAGATGTCCTAAAAGCTAGACTGTGGATT
GAGTTTGAATCAGAGAAAGGTCTTGACTATGGGGGTGTGGCCAGAGAATGGTTCTTCTTACTGTCCAAAGAGATGTTCAACCCCTACTAC
GGCCTCTTTGAGTACTCTGCCACGGACAACTACACCCTTCAGATCAACCCTAATTCAGGCCTCTGTAATGAGGATCATTTGTCCTACTTC
ACTTTTATTGGAAGAGTTGCTGGTCTGGCCGTATTTCATGGGAAGCTCTTAGATGGTTTCTTCATTAGACCATTTTACAAGATGATGTTG
GGAAAGCAGATAACCCTGAATGACATGGAATCTGTGGATAGTGAATATTACAACTCTTTGAAATGGATCCTGGAGAATGACCCTACTGAG
CTGGACCTCATGTTCTGCATAGACGAAGAAAACTTTGGACAGACATATCAAGTGGATTTGAAGCCCAATGGGTCAGAAATAATGGTCACA
AATGAAAACAAAAGGGAATATATCGACTTAGTCATCCAGTGGAGATTTGTGAACAGGGTCCAGAAGCAGATGAACGCCTTCTTGGAGGGA
TTCACAGAACTACTTCCTATTGATTTGATTAAAATTTTTGATGAAAATGAGCTGGAGTTGCTCATGTGCGGCCTCGGTGATGTGGATGTG
AATGACTGGAGACAGCATTCTATTTACAAGAACGGCTACTGCCCAAACCACCCCGTCATTCAGTGGTTCTGGAAGGCTGTGCTACTCATG
GACGCCGAAAAGCGTATCCGGTTACTGCAGTTTGTCACAGGGACATCGCGAGTACCTATGAATGGATTTGCCGAACTTTATGGTTCCAAT
GGTCCTCAGCTGTTTACAATAGAGCAATGGGGCAGTCCTGAGAAACTGCCCAGAGCTCACACATGCTTTAATCGCCTTGACTTACCTCCA
TATGAAACCTTTGAAGATTTACGAGAGAAACTTCTCATGGCCGTGGAAAATGCTCAAGGATTTGAAGGGGTGGATTAAGCACCCTGTGCC
TCGGGGGTGGTTGTTCTTCAAGCAAGTTCTGCTTGCACTTTTGCATTTGCCTAACAGACTTTTGCAGAGGCGATGGCAGAGAGCAGCTGC
AGGCATGGTCCCTGGAGCCGAGCCTTCACCACGCACTCGTCCAAGTTCGGATGCGGGAACCTGGTCCCAGCTTGAGTTCCTGCCTTTCCC
ACCACAAATTATCAACTGGTTGATGTGTACACTAATTACATTTCAGGAGGACTTAATGCTATTTATGTTGTGCCTCTGCAGGCAAAGCCC
TTAATAAATATTTTACATCCTTTCTAATGACAATGAATGGAATTAATCACTCAACAGGTATAGTATTACGACTCATGTTTACTTTTTAAA

>50393_50393_2_LUZP1-NEDD4L_LUZP1_chr1_23417683_ENST00000314174_NEDD4L_chr18_55919233_ENST00000400345_length(amino acids)=1931AA_BP=1037
MDASRSPHWLAVDMAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEG
KDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELES
SEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR
KGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQI
KKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHM
GVSTDSGTQETKKTEDRFVPGSSQSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRA
DKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQ
GFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFEN
DKDAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEKQKPVSKPGPNKVTSSIT
IYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSSPFELSIHKHDITLQLAEAERMADGPLKDRPETVVSRSSIIIKPSDPV
ERNSHAPPAETIRWKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELEQPRSCLFEQGTRR
VGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNHSASMVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMER
PYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNH
NNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSP
QELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGWEER
KDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSP
YNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKIT
QWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVA
REWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDS
EYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFD
ENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LUZP1-NEDD4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LUZP1-NEDD4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LUZP1-NEDD4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource