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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:LY6E-LY6D (FusionGDB2 ID:50415) |
Fusion Gene Summary for LY6E-LY6D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LY6E-LY6D | Fusion gene ID: 50415 | Hgene | Tgene | Gene symbol | LY6E | LY6D | Gene ID | 4061 | 8581 |
| Gene name | lymphocyte antigen 6 family member E | lymphocyte antigen 6 family member D | |
| Synonyms | RIG-E|RIGE|SCA-2|SCA2|TSA-1 | E48|Ly-6D | |
| Cytomap | 8q24.3 | 8q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lymphocyte antigen 6Ely-6Elymphocyte antigen 6 complex, locus Eretinoic acid induced gene Eretinoic acid-induced gene E proteinstem cell antigen 2thymic shared antigen 1 | lymphocyte antigen 6De48 antigenlymphocyte antigen 6 complex, locus D | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | Q16553 | Q14210 | |
| Ensembl transtripts involved in fusion gene | ENST00000292494, ENST00000429120, ENST00000517503, ENST00000520466, ENST00000521182, ENST00000521699, ENST00000519546, ENST00000519611, ENST00000519615, ENST00000520531, ENST00000521003, ENST00000522024, ENST00000522528, ENST00000522971, ENST00000523847, | ENST00000518434, ENST00000301263, | |
| Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 3 X 3 X 3=27 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LY6E [Title/Abstract] AND LY6D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | LY6E(144103826)-LY6D(143868008), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | LY6E-LY6D seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across LY6E (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across LY6D (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-F7-A623-01A | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
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Fusion Gene ORF analysis for LY6E-LY6D |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000292494 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| 5CDS-intron | ENST00000429120 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| 5CDS-intron | ENST00000517503 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| 5CDS-intron | ENST00000520466 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| 5CDS-intron | ENST00000521182 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| 5CDS-intron | ENST00000521699 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| Frame-shift | ENST00000292494 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| Frame-shift | ENST00000517503 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| Frame-shift | ENST00000520466 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| Frame-shift | ENST00000521699 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| In-frame | ENST00000429120 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| In-frame | ENST00000521182 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000519546 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000519611 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000519615 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000520531 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000521003 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000522024 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000522528 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000522971 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-3CDS | ENST00000523847 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000519546 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000519611 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000519615 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000520531 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000521003 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000522024 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000522528 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000522971 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| intron-intron | ENST00000523847 | ENST00000518434 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000429120 | LY6E | chr8 | 144103826 | - | ENST00000301263 | LY6D | chr8 | 143868008 | - | 1977 | 1173 | 734 | 0 | 245 |
| ENST00000521182 | LY6E | chr8 | 144103826 | - | ENST00000301263 | LY6D | chr8 | 143868008 | - | 1883 | 1079 | 915 | 1541 | 208 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000429120 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - | 0.676465 | 0.32353505 |
| ENST00000521182 | ENST00000301263 | LY6E | chr8 | 144103826 | - | LY6D | chr8 | 143868008 | - | 0.29061496 | 0.709385 |
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Fusion Genomic Features for LY6E-LY6D |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for LY6E-LY6D |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:144103826/chr8:143868008) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LY6E | LY6D |
| FUNCTION: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). {ECO:0000250|UniProtKB:Q64253, ECO:0000269|PubMed:32641482}.; FUNCTION: (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed:28130445, PubMed:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed:28130445, PubMed:30190477). {ECO:0000269|PubMed:28130445, ECO:0000269|PubMed:29610346, ECO:0000269|PubMed:30190477}. | FUNCTION: May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LY6E | chr8:144103826 | chr8:143868008 | ENST00000292494 | - | 4 | 4 | 21_101 | 339 | 132.0 | Domain | Note=UPAR/Ly6 |
| Hgene | LY6E | chr8:144103826 | chr8:143868008 | ENST00000429120 | - | 4 | 4 | 21_101 | 339 | 132.0 | Domain | Note=UPAR/Ly6 |
| Hgene | LY6E | chr8:144103826 | chr8:143868008 | ENST00000520466 | - | 5 | 5 | 21_101 | 338 | 132.0 | Domain | Note=UPAR/Ly6 |
| Hgene | LY6E | chr8:144103826 | chr8:143868008 | ENST00000521699 | - | 5 | 5 | 21_101 | 339 | 132.0 | Domain | Note=UPAR/Ly6 |
| Tgene | LY6D | chr8:144103826 | chr8:143868008 | ENST00000301263 | -1 | 3 | 21_108 | 17 | 129.0 | Domain | Note=UPAR/Ly6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LY6E | chr8:144103826 | chr8:143868008 | ENST00000521003 | - | 1 | 5 | 21_101 | 0 | 132.0 | Domain | Note=UPAR/Ly6 |
| Hgene | LY6E | chr8:144103826 | chr8:143868008 | ENST00000522024 | - | 1 | 5 | 21_101 | 0 | 132.0 | Domain | Note=UPAR/Ly6 |
| Hgene | LY6E | chr8:144103826 | chr8:143868008 | ENST00000522971 | - | 1 | 4 | 21_101 | 0 | 132.0 | Domain | Note=UPAR/Ly6 |
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Fusion Gene Sequence for LY6E-LY6D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >50415_50415_1_LY6E-LY6D_LY6E_chr8_144103826_ENST00000429120_LY6D_chr8_143868008_ENST00000301263_length(transcript)=1977nt_BP=1173nt CCGGGGCCGCGCGGCTGCCTGGGAGGCTCCGGGCCAGCCGCGGTCCAGAGCGCGCGAGGTTCGGGGAGCTCGGCCAGGCTGCTGGTACCT GCGTCCGCCCGGCGGACAGGCTGCTTTGGTTTGTGACCTCCAGGCAGGACGGCCATCCTCTCCAGAATGAAGATCTTCTTGCCAGTGCTG CTGGCTGCCCTTCTGGGTGTGGAGCGAGCCAGCTCGCTGATGTGCTTCTCCTGCTTGAACCAGAAGAGCAATCTGTACTGCCTGAAGCCG ACCATCTGCTCCGACCAGGACAACTACTGCGTGACTGTGTCTGCTAGTGCCGGCATTGGGAATCTCGTGACATTTGGCCACAGCCTGAGC AAGACCTGTTCCCCGGCCTGCCCCATCCCAGAAGGCGTCAATGTTGGTGTGGCTTCCATGGGCATCAGCTGCTGCCAGAGCTTTCTGTGC AATTTCAGTGCGGCCGATGGCGGGCTGCGGGCAAGCGTCACCCTGCTGGGTGCCGGGCTGCTGCTGAGCCTGCTGCCGGCCCTGCTGCGG TTTGGCCCCTGACCGCCCAGACCCTGTCCCCCGATCCCCCAGCTCAGGAAGGAAAGCCCAGCCCTTTCTGGATCCCACAGTGTATGGGAG CCCCTGACTCCTCACGTGCCTGATCTGTGCCCTTGGTCCCAGGTCAGGCCCACCCCCTGCACCTCCACCTGCCCCAGCCCCTGCCTCTGC CCCAAGTGGGGCCAGCTGCCCTCACTTCTGGGGTGGATGATGTGACCTTCCTTGGGGGACCGCGGAAGGGACGAGGGTTCCCTGGAGTCT TACGGTCCAACATCAGGACCAAGTCCCATGGACATGCTGACAGGGTCCCCAGGGAGACCGTGTCAGTAGGGATGTGTGCCTGGCTGTGTA CGTGGGTGTGCAGTGCACGTGAGAGCACGTGGCGGCTTCTGGGGGCCATGTTTGGGGAGGGAGGTGTGCCAGCAGCCTGGAGAGCCTCAG TCCCTGTAGCCCCCTGCCCTGGCACAGCTGCATGCACTTCAAGGGCAGCCTTTGGGGGTTGGGGTTTCTGCCACTTCCGGGTCTAGGCCC TGCCCCAAATCCAGCCAGTCCTGCCCCAGCCCACCCCCACATTGGAGCCCTCCTGCTGCTTTGGTGCCTCAAATAAATACAGATGTCCCC CAGGCCCACCCCCGCCCAGCCCGTGCCTATAAGGCCTTGGCAATGCAGGGGCCCGCACTGCTCCCAGACGACATCAGAGATGAGGACAGC ATTGCTGCTCCTTGCAGCCCTGGCTGTGGCTACAGGGCCAGCCCTTACCCTGCGCTGCCACGTGTGCACCAGCTCCAGCAACTGCAAGCA TTCTGTGGTCTGCCCGGCCAGCTCTCGCTTCTGCAAGACCACGAACACAGTGGAGCCTCTGAGGGGGAATCTGGTGAAGAAGGACTGTGC GGAGTCGTGCACACCCAGCTACACCCTGCAAGGCCAGGTCAGCAGCGGCACCAGCTCCACCCAGTGCTGCCAGGAGGACCTGTGCAATGA GAAGCTGCACAACGCTGCACCCACCCGCACCGCCCTCGCCCACAGTGCCCTCAGCCTGGGGCTGGCCCTGAGCCTCCTGGCCGTCATCTT AGCCCCCAGCCTGTGACCTTCCCCCCAGGGAAGGCCCCTCATGCCTTTCCTTCCCTTTCTCTGGGGATTCCACACCTCTCTTCCCCAGCC GCAACGGGGGTGCCAGGAGCCCCAGGCTGAGGGCTTCCCCGAAAGTCTGGGACCAGGTCCAGGTGGGCATGGAATGCTGATGACTTGGAG CAGGCCCCACAGACCCCACAGAGGATGAAGCCACCCCACAGAGGATGCAGCCCCCAGCTGCATGGAAGGTGGAGGACAGAAGCCCTGTGG >50415_50415_1_LY6E-LY6D_LY6E_chr8_144103826_ENST00000429120_LY6D_chr8_143868008_ENST00000301263_length(amino acids)=245AA_BP= MAPLGAEAGAGAGGGAGGGPDLGPRAQIRHVRSQGLPYTVGSRKGWAFLPELGDRGTGSGRSGAKPQQGRQQAQQQPGTQQGDACPQPAI GRTEIAQKALAAADAHGSHTNIDAFWDGAGRGTGLAQAVAKCHEIPNAGTSRHSHAVVVLVGADGRLQAVQIALLVQAGEAHQRAGSLHT -------------------------------------------------------------- >50415_50415_2_LY6E-LY6D_LY6E_chr8_144103826_ENST00000521182_LY6D_chr8_143868008_ENST00000301263_length(transcript)=1883nt_BP=1079nt GGGAGCTCGGCCAGGCTGCTGGTACCTGCGTCCGCCCGGCGAGCAGGACAGGCTGCTTTGGTTTGTGACCTCCAGGCAGGACGGCCATCC TCTCCAGAATGAAGATCTTCTTGCCAGTGCTGCTGGCTGCCCTTCTGGGTGTGGAGCGAGAAGAGCAATCTGTACTGCCTGAAGCCGACC ATCTGCTCCGACCAGGACAACTACTGCGTGACTGTGTCTGCTAGTGCCGGCATTGGGAATCTCGTGACATTTGGCCACAGCCTGAGCAAG ACCTGTTCCCCGGCCTGCCCCATCCCAGAAGGCGTCAATGTTGGTGTGGCTTCCATGGGCATCAGCTGCTGCCAGAGCTTTCTGTGCAAT TTCAGTGCGGCCGATGGCGGGCTGCGGGCAAGCGTCACCCTGCTGGGTGCCGGGCTGCTGCTGAGCCTGCTGCCGGCCCTGCTGCGGTTT GGCCCCTGACCGCCCAGACCCTGTCCCCCGATCCCCCAGCTCAGGAAGGAAAGCCCAGCCCTTTCTGGATCCCACAGTGTATGGGAGCCC CTGACTCCTCACGTGCCTGATCTGTGCCCTTGGTCCCAGGTCAGGCCCACCCCCTGCACCTCCACCTGCCCCAGCCCCTGCCTCTGCCCC AAGTGGGGCCAGCTGCCCTCACTTCTGGGGTGGATGATGTGACCTTCCTTGGGGGACCGCGGAAGGGACGAGGGTTCCCTGGAGTCTTAC GGTCCAACATCAGGACCAAGTCCCATGGACATGCTGACAGGGTCCCCAGGGAGACCGTGTCAGTAGGGATGTGTGCCTGGCTGTGTACGT GGGTGTGCAGTGCACGTGAGAGCACGTGGCGGCTTCTGGGGGCCATGTTTGGGGAGGGAGGTGTGCCAGCAGCCTGGAGAGCCTCAGTCC CTGTAGCCCCCTGCCCTGGCACAGCTGCATGCACTTCAAGGGCAGCCTTTGGGGGTTGGGGTTTCTGCCACTTCCGGGTCTAGGCCCTGC CCCAAATCCAGCCAGTCCTGCCCCAGCCCACCCCCACATTGGAGCCCTCCTGCTGCTTTGGTGCCTCAAATAAATACAGATGTCCCCCAG CCCACCCCCGCCCAGCCCGTGCCTATAAGGCCTTGGCAATGCAGGGGCCCGCACTGCTCCCAGACGACATCAGAGATGAGGACAGCATTG CTGCTCCTTGCAGCCCTGGCTGTGGCTACAGGGCCAGCCCTTACCCTGCGCTGCCACGTGTGCACCAGCTCCAGCAACTGCAAGCATTCT GTGGTCTGCCCGGCCAGCTCTCGCTTCTGCAAGACCACGAACACAGTGGAGCCTCTGAGGGGGAATCTGGTGAAGAAGGACTGTGCGGAG TCGTGCACACCCAGCTACACCCTGCAAGGCCAGGTCAGCAGCGGCACCAGCTCCACCCAGTGCTGCCAGGAGGACCTGTGCAATGAGAAG CTGCACAACGCTGCACCCACCCGCACCGCCCTCGCCCACAGTGCCCTCAGCCTGGGGCTGGCCCTGAGCCTCCTGGCCGTCATCTTAGCC CCCAGCCTGTGACCTTCCCCCCAGGGAAGGCCCCTCATGCCTTTCCTTCCCTTTCTCTGGGGATTCCACACCTCTCTTCCCCAGCCGCAA CGGGGGTGCCAGGAGCCCCAGGCTGAGGGCTTCCCCGAAAGTCTGGGACCAGGTCCAGGTGGGCATGGAATGCTGATGACTTGGAGCAGG CCCCACAGACCCCACAGAGGATGAAGCCACCCCACAGAGGATGCAGCCCCCAGCTGCATGGAAGGTGGAGGACAGAAGCCCTGTGGATCC >50415_50415_2_LY6E-LY6D_LY6E_chr8_144103826_ENST00000521182_LY6D_chr8_143868008_ENST00000301263_length(amino acids)=208AA_BP=55 MAQLHALQGQPLGVGVSATSGSRPCPKSSQSCPSPPPHWSPPAALVPQINTDVPQPTPAQPVPIRPWQCRGPHCSQTTSEMRTALLLLAA LAVATGPALTLRCHVCTSSSNCKHSVVCPASSRFCKTTNTVEPLRGNLVKKDCAESCTPSYTLQGQVSSGTSSTQCCQEDLCNEKLHNAA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for LY6E-LY6D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LY6E-LY6D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LY6E-LY6D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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