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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LYPLA1-ANO3 (FusionGDB2 ID:50465)

Fusion Gene Summary for LYPLA1-ANO3

check button Fusion gene summary
Fusion gene informationFusion gene name: LYPLA1-ANO3
Fusion gene ID: 50465
HgeneTgene
Gene symbol

LYPLA1

ANO3

Gene ID

10434

63982

Gene namelysophospholipase 1anoctamin 3
SynonymsAPT-1|APT1|LPL-I|LPL1|hAPT1C11orf25|DYT23|DYT24|GENX-3947|TMEM16C
Cytomap

8q11.23

11p14.3-p14.2

Type of geneprotein-codingprotein-coding
Descriptionacyl-protein thioesterase 1lysoPLA Ilysophospholipase Ilysophospholipid-specific lysophospholipaseanoctamin-3dystonia 23transmembrane protein 16C (eight membrane-spanning domains)
Modification date2020031320200313
UniProtAcc

O75608

Q9BYT9

Ensembl transtripts involved in fusion geneENST00000316963, ENST00000343231, 
ENST00000522007, ENST00000519926, 
ENST00000529242, ENST00000531568, 
ENST00000531646, ENST00000256737, 
ENST00000525139, ENST00000537978, 
Fusion gene scores* DoF score7 X 7 X 3=14711 X 9 X 5=495
# samples 912
** MAII scorelog2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/495*10)=-2.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LYPLA1 [Title/Abstract] AND ANO3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLYPLA1(55013468)-ANO3(26574796), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LYPLA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANO3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-MV-A51V-01ALYPLA1chr8

55013468

-ANO3chr11

26574796

+


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Fusion Gene ORF analysis for LYPLA1-ANO3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000316963ENST00000529242LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-3UTRENST00000343231ENST00000529242LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-3UTRENST00000522007ENST00000529242LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-intronENST00000316963ENST00000531568LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-intronENST00000316963ENST00000531646LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-intronENST00000343231ENST00000531568LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-intronENST00000343231ENST00000531646LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-intronENST00000522007ENST00000531568LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5CDS-intronENST00000522007ENST00000531646LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5UTR-3CDSENST00000519926ENST00000256737LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5UTR-3CDSENST00000519926ENST00000525139LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5UTR-3CDSENST00000519926ENST00000537978LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5UTR-3UTRENST00000519926ENST00000529242LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5UTR-intronENST00000519926ENST00000531568LYPLA1chr8

55013468

-ANO3chr11

26574796

+
5UTR-intronENST00000519926ENST00000531646LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000316963ENST00000256737LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000316963ENST00000525139LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000316963ENST00000537978LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000343231ENST00000256737LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000343231ENST00000525139LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000343231ENST00000537978LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000522007ENST00000256737LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000522007ENST00000525139LYPLA1chr8

55013468

-ANO3chr11

26574796

+
In-frameENST00000522007ENST00000537978LYPLA1chr8

55013468

-ANO3chr11

26574796

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316963LYPLA1chr855013468-ENST00000537978ANO3chr1126574796+2188295711951626
ENST00000316963LYPLA1chr855013468-ENST00000525139ANO3chr1126574796+2188295711951626
ENST00000316963LYPLA1chr855013468-ENST00000256737ANO3chr1126574796+4796295711951626
ENST00000343231LYPLA1chr855013468-ENST00000537978ANO3chr1126574796+199910651762585
ENST00000343231LYPLA1chr855013468-ENST00000525139ANO3chr1126574796+199910651762585
ENST00000343231LYPLA1chr855013468-ENST00000256737ANO3chr1126574796+460710651762585
ENST00000522007LYPLA1chr855013468-ENST00000537978ANO3chr1126574796+202613381789593
ENST00000522007LYPLA1chr855013468-ENST00000525139ANO3chr1126574796+202613381789593
ENST00000522007LYPLA1chr855013468-ENST00000256737ANO3chr1126574796+463413381789593

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316963ENST00000537978LYPLA1chr855013468-ANO3chr1126574796+0.0014065750.9985934
ENST00000316963ENST00000525139LYPLA1chr855013468-ANO3chr1126574796+0.0014065750.9985934
ENST00000316963ENST00000256737LYPLA1chr855013468-ANO3chr1126574796+0.0007923050.9992077
ENST00000343231ENST00000537978LYPLA1chr855013468-ANO3chr1126574796+0.0013649440.998635
ENST00000343231ENST00000525139LYPLA1chr855013468-ANO3chr1126574796+0.0013649440.998635
ENST00000343231ENST00000256737LYPLA1chr855013468-ANO3chr1126574796+0.0007715980.99922836
ENST00000522007ENST00000537978LYPLA1chr855013468-ANO3chr1126574796+0.0014013630.99859864
ENST00000522007ENST00000525139LYPLA1chr855013468-ANO3chr1126574796+0.0014013630.99859864
ENST00000522007ENST00000256737LYPLA1chr855013468-ANO3chr1126574796+0.0007751560.9992248

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Fusion Genomic Features for LYPLA1-ANO3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LYPLA1chr855013467-ANO3chr1126574795+3.61E-060.9999964
LYPLA1chr855013467-ANO3chr1126574795+3.61E-060.9999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LYPLA1-ANO3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:55013468/chr11:26574796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYPLA1

O75608

ANO3

Q9BYT9

FUNCTION: Acts as a acyl-protein thioesterase (PubMed:19439193, PubMed:20418879). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:20418879). Has depalmitoylating activity toward KCNMA1 (PubMed:22399288). Could also depalmitoylate ADRB2 (PubMed:27481942). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed:19439193). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (PubMed:19439193). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed:21393252). {ECO:0000250|UniProtKB:P70470, ECO:0000269|PubMed:19439193, ECO:0000269|PubMed:20418879, ECO:0000269|PubMed:21393252, ECO:0000269|PubMed:22399288, ECO:0000269|PubMed:27481942}.FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732). {ECO:0000250|UniProtKB:A2AHL1, ECO:0000303|PubMed:21984732}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127491_550429982.0Topological domainCytoplasmic
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127572_592429982.0Topological domainExtracellular
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127614_640429982.0Topological domainCytoplasmic
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127662_761429982.0Topological domainExtracellular
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127783_810429982.0Topological domainCytoplasmic
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127832_914429982.0Topological domainExtracellular
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127936_981429982.0Topological domainCytoplasmic
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127470_490429982.0TransmembraneHelical
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127551_571429982.0TransmembraneHelical
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127593_613429982.0TransmembraneHelical
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127641_661429982.0TransmembraneHelical
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127762_782429982.0TransmembraneHelical
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127811_831429982.0TransmembraneHelical
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127915_935429982.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANO3chr8:55013468chr11:26574796ENST0000025673711271_403429982.0Topological domainCytoplasmic
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127425_469429982.0Topological domainExtracellular
TgeneANO3chr8:55013468chr11:26574796ENST000002567371127404_424429982.0TransmembraneHelical


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Fusion Gene Sequence for LYPLA1-ANO3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50465_50465_1_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000316963_ANO3_chr11_26574796_ENST00000256737_length(transcript)=4796nt_BP=295nt
CGGCGGGCGAGGGGCAGGGCAGGGCGGACCCTGGACGCGCGGGCGCGCGCGGAAGGTAGCGCGGGGCCGCGTTGGCGCGCACGCGCCTGA
GCGTGCGCCCGGTGGGGCCGGCCGGGACTCGCCGCTCGCACGCCCTTGGGCCGCGGCCGGGCGCCCGCTCTTCCTTCCGCTTGCGCTGTG
AGCTGAGGCGGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCCACCGCTGCGGTGATTT
TCCTGCATGGATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTGACAAGAACTGCTCCCTGC
AGAGACTCAACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTGCTATTTTTATGGCAATAT
GGGCCACAGTCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAATGGGAAGAAGAGGAGGAAA
CACTTCGTCCCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAACCACATCAGCCTTCCTCAG
ACAAAGTCACTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGTTTGGAGTTGTGGTGTACC
GCCTGGTTGTCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACATCTGCTGCTGCTGTCTGTA
TCAATTTCATAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAATATCCTCGAACAGAATCAG
AGTGGGAAAACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATATCGCTTTCTTTTTGGGAA
GATTCGTAGGCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTGGCTGTTTGATAGACCTCT
GCCTCCAGATGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGATCCAGAACTGGTGGTCAC
GACATAAAATCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCATGAACCTTCATGGACTGA
TGGATGAGTACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCCCTCTTTTGGCTTTGTTAA
ACAATATCATTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAGCAACTGACATAGGTATCT
GGCTTGGAATTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTGATTACATCCCACGTTTTG
TTTATGAATACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCAACAATAGCCTATCCTTCT
TTGACCTGAGTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGAGTTCCAAACCCTATGAGT
TTACTTTACAATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTGGGATTAAGTCATTCATCG
CATACCTGATTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAATGATGTATGAGGCTGAAC
TGGAACATTTGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTGTTACCCATTAGGGGTGAT
AACATTAATGGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAACCACATGTATAATATGCT
ACTTGGAAATGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTGACGACCTTAAAAAGGGTT
AGATTGACATTGCAGGAAGCCAGGATGTAATTCTCAGAACCAGTCTCAGGGAGATATATGCTTGGAGAACTCTGCCTTCCATCAACTGCA
GTGTAATGGGAAAGAGGGTGGTGAGGTTTTGAAAGACAGATTTCCATGTAAATGTGCACAAGCCAGGCATGGCTTAAAATATCATGCAGT
CTTCACTCACATACTAATTTGACTTTGGAAAGTATGGTTGAGTTCAGATACTTATAAGAAATGACTTAAACAAATCCTTGCCTTGGCTGC
CAGAACTCTACATCCCTTCAGTTTACAGGTTGGTAGGAATTGCCCATGTCTCTTGCTGAGATTATGGATCTGTGCCACAGGGGATTTATG
CTGCTTTACATTGACTATGCAGTTGAAGAGTTGCACATCACCTTTAGTAGTCAAACCAAAAATCTAAGATTCCAAAAAGAACAGCATTCA
TTGAAATAATATTCCATTGCATTGGCTACTTCAAGTCTCTTTTACCCCTGGCAGAGCCAGTTGCAGTGCAATTTTTTGTACTAAATGCCA
ATAAAGCCACATACTTATAAACTATGAATGGCTATTCTTATATAGTTTAGAACACAACTAATCCATACTTTATTGTGGAAGGCTGTTTTA
TAGTTTATTTAATTTTTTCTCTATGATTTATTACAACTCTCACGGAATATTAACTTGAAATGCTGTAAATACGTTGGTTTTCCTTGTCCC
TTTGCACCTTGACAGTACGTAGTATACATTGTGGTTTATGCAGCTCTGACACCAGTTTTTGCTATTGTAATATGTTTATTCGGGAAAACT
GAGGCCAGATGCTCTGCAACACTTACGCTTTTTCAACAATGTGCACTCTTACTCATGAACTAATGAAAATAATGCATGAATATAAATCTA
TATTATTTGCTAAAAAAAGAAAAAACATTTGTGTTTTAGTTTCTTTTTTCATGACTGAAGGGAGTTTTATGTTATTATTTCTTCCATAGT
TTTGTTTTGGTTTATTTTTAACAACGCTCTAGAAACAAAGTCAAATTAATCACAAAAGACATAATTTTGCTTTGTTGTGGAATTTCTATT
TCAACGTCAACTCTGTATCTATGAGTATGTCTGTTCCACAGACAGATGAGGCAGGAGTGATGGGGCACTCAAGAAAGTTCAGAGGAGGCA
TAAGCTATGGAGGTTGGAAAGGAAGAAAGAGAAGAGCTGAAGTAAATGTATGGTAGAAATTAAGACGTTTCTTTGCAAAACAAGGAAATC
ACACATATGCACACATACATATTTATGGTTACTATGATTGTTATTATTTGTCCAATCAAGCAAAGCACCATTATTTCTAACATATAAAAG
ACCAGATCAAACACAATGGAAATAAAGCTACTACATATATATGCCAGTATTTCTCTAGTAAGATTATGTTTCTCTTACTAGAAAACTATT
TTCTAAATATTAACACTGAAAATGTTTTGTTAGCTTTTCCTTCTTTCTCTCCAGAAGAAACATGGATAGATGATAGCTGTTTCATTGTTT
GTTTTTGTCAAGCATATTCACTTTCCTCCTTGTCCTCTGATTCTGAGCAAAGGGCCTCAGACTCTGAACTTCCCTCAAGTGCCGTTGTTA
TGTGAAACTCTTCCATTCAGATTCCAGAGAGGTTCTCATGCTCCCCCCCCTCCTTATTTGTAGCAATCGTAGCAACTAATTCCACTAAGT
ACAAGGGAGTTTTTTACACTCCTCCATTTTTATAGCATCTGCATTTCTTTTTCTTTGTTAGGTACATGTATACACCTGCCTGAGTATAAA
TACTCTCTCTACCTAATAATAACATCAACCAACATCTTTTCCAAATTAGGGCCACAGAACAGCAACATTTGTCTGACAGTAGTATAAAGA
ATAATGATAGCTCTATCCTTAAGAAGTATTTCCTTTCCTTTTTATATAGTCCCGTTAGGGTTTAAAACCATATTGATCAACTAGAAAGAA
AAATATGAAAAGAGAAAAATATTTTAATTTAAAAATTGTAATACATTGATTTATAAAATGCCTTCTCTGATACTTTTGAAACAGATGTGA
AAAACAGAAAAAGAAAAAATTGTCTGAAATGTTTATTTTGCAAAACAGTGCAATAGAATCTAGTTATGCCTTCATCACTGTTGACAGTAA
ATACTGACAGCCCCTTGCAGTGTGTTAGTTTTAGATCACTCTGTTTTAGTTGAGAGAAATGTTTTATATCATGGTTTTTATATGAATACA
AATTATTTCTCAAAGATTTATAGCACACACTATTCTCAGGAATTCTGTATTACATGAATGCTGCTTATATATTTTCATATTCTAACTTGT
CTTTTCAAGCAAATAACTAATATATATGTGCATGCAGTCTGCCTTGACAAGTTGTTCCAAGCTGAAGAGCTTTCACTGTACAATGTGTGG
AAAATCACCATAGATCATGGCTGAAATAGTTTGTAATTGTCTGAGTCTGTGCACGTACTTTTAGATAAAATGCTGCTGAGTGACTGCATG
ATGAGATACAACTTCTGAATGCTGCACATTCTTCCAAAATGATCCTTAGCACAATCTATTGTATGATGGAATGAATAGAAAACTTTTTCA

>50465_50465_1_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000316963_ANO3_chr11_26574796_ENST00000256737_length(amino acids)=626AA_BP=69
MARTRLSVRPVGPAGTRRSHALGPRPGARSSFRLRCELRRCMCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLC
DKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPE
PHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLE
YPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPL
IQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPAR
ATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPW

--------------------------------------------------------------
>50465_50465_2_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000316963_ANO3_chr11_26574796_ENST00000525139_length(transcript)=2188nt_BP=295nt
CGGCGGGCGAGGGGCAGGGCAGGGCGGACCCTGGACGCGCGGGCGCGCGCGGAAGGTAGCGCGGGGCCGCGTTGGCGCGCACGCGCCTGA
GCGTGCGCCCGGTGGGGCCGGCCGGGACTCGCCGCTCGCACGCCCTTGGGCCGCGGCCGGGCGCCCGCTCTTCCTTCCGCTTGCGCTGTG
AGCTGAGGCGGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCCACCGCTGCGGTGATTT
TCCTGCATGGATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTGACAAGAACTGCTCCCTGC
AGAGACTCAACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTGCTATTTTTATGGCAATAT
GGGCCACAGTCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAATGGGAAGAAGAGGAGGAAA
CACTTCGTCCCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAACCACATCAGCCTTCCTCAG
ACAAAGTCACTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGTTTGGAGTTGTGGTGTACC
GCCTGGTTGTCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACATCTGCTGCTGCTGTCTGTA
TCAATTTCATAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAATATCCTCGAACAGAATCAG
AGTGGGAAAACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATATCGCTTTCTTTTTGGGAA
GATTCGTAGGCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTGGCTGTTTGATAGACCTCT
GCCTCCAGATGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGATCCAGAACTGGTGGTCAC
GACATAAAATCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCATGAACCTTCATGGACTGA
TGGATGAGTACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCCCTCTTTTGGCTTTGTTAA
ACAATATCATTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAGCAACTGACATAGGTATCT
GGCTTGGAATTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTGATTACATCCCACGTTTTG
TTTATGAATACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCAACAATAGCCTATCCTTCT
TTGACCTGAGTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGAGTTCCAAACCCTATGAGT
TTACTTTACAATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTGGGATTAAGTCATTCATCG
CATACCTGATTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAATGATGTATGAGGCTGAAC
TGGAACATTTGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTGTTACCCATTAGGGGTGAT
AACATTAATGGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAACCACATGTATAATATGCT
ACTTGGAAATGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTGACGACCTTAAAAAGGGTT

>50465_50465_2_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000316963_ANO3_chr11_26574796_ENST00000525139_length(amino acids)=626AA_BP=69
MARTRLSVRPVGPAGTRRSHALGPRPGARSSFRLRCELRRCMCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLC
DKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPE
PHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLE
YPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPL
IQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPAR
ATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPW

--------------------------------------------------------------
>50465_50465_3_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000316963_ANO3_chr11_26574796_ENST00000537978_length(transcript)=2188nt_BP=295nt
CGGCGGGCGAGGGGCAGGGCAGGGCGGACCCTGGACGCGCGGGCGCGCGCGGAAGGTAGCGCGGGGCCGCGTTGGCGCGCACGCGCCTGA
GCGTGCGCCCGGTGGGGCCGGCCGGGACTCGCCGCTCGCACGCCCTTGGGCCGCGGCCGGGCGCCCGCTCTTCCTTCCGCTTGCGCTGTG
AGCTGAGGCGGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCCACCGCTGCGGTGATTT
TCCTGCATGGATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTGACAAGAACTGCTCCCTGC
AGAGACTCAACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTGCTATTTTTATGGCAATAT
GGGCCACAGTCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAATGGGAAGAAGAGGAGGAAA
CACTTCGTCCCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAACCACATCAGCCTTCCTCAG
ACAAAGTCACTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGTTTGGAGTTGTGGTGTACC
GCCTGGTTGTCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACATCTGCTGCTGCTGTCTGTA
TCAATTTCATAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAATATCCTCGAACAGAATCAG
AGTGGGAAAACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATATCGCTTTCTTTTTGGGAA
GATTCGTAGGCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTGGCTGTTTGATAGACCTCT
GCCTCCAGATGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGATCCAGAACTGGTGGTCAC
GACATAAAATCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCATGAACCTTCATGGACTGA
TGGATGAGTACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCCCTCTTTTGGCTTTGTTAA
ACAATATCATTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAGCAACTGACATAGGTATCT
GGCTTGGAATTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTGATTACATCCCACGTTTTG
TTTATGAATACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCAACAATAGCCTATCCTTCT
TTGACCTGAGTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGAGTTCCAAACCCTATGAGT
TTACTTTACAATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTGGGATTAAGTCATTCATCG
CATACCTGATTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAATGATGTATGAGGCTGAAC
TGGAACATTTGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTGTTACCCATTAGGGGTGAT
AACATTAATGGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAACCACATGTATAATATGCT
ACTTGGAAATGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTGACGACCTTAAAAAGGGTT

>50465_50465_3_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000316963_ANO3_chr11_26574796_ENST00000537978_length(amino acids)=626AA_BP=69
MARTRLSVRPVGPAGTRRSHALGPRPGARSSFRLRCELRRCMCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLC
DKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPE
PHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLE
YPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPL
IQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPAR
ATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPW

--------------------------------------------------------------
>50465_50465_4_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000343231_ANO3_chr11_26574796_ENST00000256737_length(transcript)=4607nt_BP=106nt
GGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCCACCGCTGCGGTGATTTTCCTGCATG
GATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTGACAAGAACTGCTCCCTGCAGAGACTCA
ACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTGCTATTTTTATGGCAATATGGGCCACAG
TCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAATGGGAAGAAGAGGAGGAAACACTTCGTC
CCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAACCACATCAGCCTTCCTCAGACAAAGTCA
CTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGTTTGGAGTTGTGGTGTACCGCCTGGTTG
TCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACATCTGCTGCTGCTGTCTGTATCAATTTCA
TAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAATATCCTCGAACAGAATCAGAGTGGGAAA
ACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATATCGCTTTCTTTTTGGGAAGATTCGTAG
GCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTGGCTGTTTGATAGACCTCTGCCTCCAGA
TGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGATCCAGAACTGGTGGTCACGACATAAAA
TCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCATGAACCTTCATGGACTGATGGATGAGT
ACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCCCTCTTTTGGCTTTGTTAAACAATATCA
TTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAGCAACTGACATAGGTATCTGGCTTGGAA
TTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTGATTACATCCCACGTTTTGTTTATGAAT
ACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCAACAATAGCCTATCCTTCTTTGACCTGA
GTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGAGTTCCAAACCCTATGAGTTTACTTTAC
AATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTGGGATTAAGTCATTCATCGCATACCTGA
TTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAATGATGTATGAGGCTGAACTGGAACATT
TGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTGTTACCCATTAGGGGTGATAACATTAAT
GGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAACCACATGTATAATATGCTACTTGGAAA
TGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTGACGACCTTAAAAAGGGTTAGATTGACA
TTGCAGGAAGCCAGGATGTAATTCTCAGAACCAGTCTCAGGGAGATATATGCTTGGAGAACTCTGCCTTCCATCAACTGCAGTGTAATGG
GAAAGAGGGTGGTGAGGTTTTGAAAGACAGATTTCCATGTAAATGTGCACAAGCCAGGCATGGCTTAAAATATCATGCAGTCTTCACTCA
CATACTAATTTGACTTTGGAAAGTATGGTTGAGTTCAGATACTTATAAGAAATGACTTAAACAAATCCTTGCCTTGGCTGCCAGAACTCT
ACATCCCTTCAGTTTACAGGTTGGTAGGAATTGCCCATGTCTCTTGCTGAGATTATGGATCTGTGCCACAGGGGATTTATGCTGCTTTAC
ATTGACTATGCAGTTGAAGAGTTGCACATCACCTTTAGTAGTCAAACCAAAAATCTAAGATTCCAAAAAGAACAGCATTCATTGAAATAA
TATTCCATTGCATTGGCTACTTCAAGTCTCTTTTACCCCTGGCAGAGCCAGTTGCAGTGCAATTTTTTGTACTAAATGCCAATAAAGCCA
CATACTTATAAACTATGAATGGCTATTCTTATATAGTTTAGAACACAACTAATCCATACTTTATTGTGGAAGGCTGTTTTATAGTTTATT
TAATTTTTTCTCTATGATTTATTACAACTCTCACGGAATATTAACTTGAAATGCTGTAAATACGTTGGTTTTCCTTGTCCCTTTGCACCT
TGACAGTACGTAGTATACATTGTGGTTTATGCAGCTCTGACACCAGTTTTTGCTATTGTAATATGTTTATTCGGGAAAACTGAGGCCAGA
TGCTCTGCAACACTTACGCTTTTTCAACAATGTGCACTCTTACTCATGAACTAATGAAAATAATGCATGAATATAAATCTATATTATTTG
CTAAAAAAAGAAAAAACATTTGTGTTTTAGTTTCTTTTTTCATGACTGAAGGGAGTTTTATGTTATTATTTCTTCCATAGTTTTGTTTTG
GTTTATTTTTAACAACGCTCTAGAAACAAAGTCAAATTAATCACAAAAGACATAATTTTGCTTTGTTGTGGAATTTCTATTTCAACGTCA
ACTCTGTATCTATGAGTATGTCTGTTCCACAGACAGATGAGGCAGGAGTGATGGGGCACTCAAGAAAGTTCAGAGGAGGCATAAGCTATG
GAGGTTGGAAAGGAAGAAAGAGAAGAGCTGAAGTAAATGTATGGTAGAAATTAAGACGTTTCTTTGCAAAACAAGGAAATCACACATATG
CACACATACATATTTATGGTTACTATGATTGTTATTATTTGTCCAATCAAGCAAAGCACCATTATTTCTAACATATAAAAGACCAGATCA
AACACAATGGAAATAAAGCTACTACATATATATGCCAGTATTTCTCTAGTAAGATTATGTTTCTCTTACTAGAAAACTATTTTCTAAATA
TTAACACTGAAAATGTTTTGTTAGCTTTTCCTTCTTTCTCTCCAGAAGAAACATGGATAGATGATAGCTGTTTCATTGTTTGTTTTTGTC
AAGCATATTCACTTTCCTCCTTGTCCTCTGATTCTGAGCAAAGGGCCTCAGACTCTGAACTTCCCTCAAGTGCCGTTGTTATGTGAAACT
CTTCCATTCAGATTCCAGAGAGGTTCTCATGCTCCCCCCCCTCCTTATTTGTAGCAATCGTAGCAACTAATTCCACTAAGTACAAGGGAG
TTTTTTACACTCCTCCATTTTTATAGCATCTGCATTTCTTTTTCTTTGTTAGGTACATGTATACACCTGCCTGAGTATAAATACTCTCTC
TACCTAATAATAACATCAACCAACATCTTTTCCAAATTAGGGCCACAGAACAGCAACATTTGTCTGACAGTAGTATAAAGAATAATGATA
GCTCTATCCTTAAGAAGTATTTCCTTTCCTTTTTATATAGTCCCGTTAGGGTTTAAAACCATATTGATCAACTAGAAAGAAAAATATGAA
AAGAGAAAAATATTTTAATTTAAAAATTGTAATACATTGATTTATAAAATGCCTTCTCTGATACTTTTGAAACAGATGTGAAAAACAGAA
AAAGAAAAAATTGTCTGAAATGTTTATTTTGCAAAACAGTGCAATAGAATCTAGTTATGCCTTCATCACTGTTGACAGTAAATACTGACA
GCCCCTTGCAGTGTGTTAGTTTTAGATCACTCTGTTTTAGTTGAGAGAAATGTTTTATATCATGGTTTTTATATGAATACAAATTATTTC
TCAAAGATTTATAGCACACACTATTCTCAGGAATTCTGTATTACATGAATGCTGCTTATATATTTTCATATTCTAACTTGTCTTTTCAAG
CAAATAACTAATATATATGTGCATGCAGTCTGCCTTGACAAGTTGTTCCAAGCTGAAGAGCTTTCACTGTACAATGTGTGGAAAATCACC
ATAGATCATGGCTGAAATAGTTTGTAATTGTCTGAGTCTGTGCACGTACTTTTAGATAAAATGCTGCTGAGTGACTGCATGATGAGATAC
AACTTCTGAATGCTGCACATTCTTCCAAAATGATCCTTAGCACAATCTATTGTATGATGGAATGAATAGAAAACTTTTTCACTCAATAAA

>50465_50465_4_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000343231_ANO3_chr11_26574796_ENST00000256737_length(amino acids)=585AA_BP=28
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVF
LEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVM
EQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGH
PGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYL
EMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYK
YGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIP

--------------------------------------------------------------
>50465_50465_5_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000343231_ANO3_chr11_26574796_ENST00000525139_length(transcript)=1999nt_BP=106nt
GGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCCACCGCTGCGGTGATTTTCCTGCATG
GATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTGACAAGAACTGCTCCCTGCAGAGACTCA
ACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTGCTATTTTTATGGCAATATGGGCCACAG
TCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAATGGGAAGAAGAGGAGGAAACACTTCGTC
CCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAACCACATCAGCCTTCCTCAGACAAAGTCA
CTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGTTTGGAGTTGTGGTGTACCGCCTGGTTG
TCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACATCTGCTGCTGCTGTCTGTATCAATTTCA
TAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAATATCCTCGAACAGAATCAGAGTGGGAAA
ACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATATCGCTTTCTTTTTGGGAAGATTCGTAG
GCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTGGCTGTTTGATAGACCTCTGCCTCCAGA
TGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGATCCAGAACTGGTGGTCACGACATAAAA
TCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCATGAACCTTCATGGACTGATGGATGAGT
ACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCCCTCTTTTGGCTTTGTTAAACAATATCA
TTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAGCAACTGACATAGGTATCTGGCTTGGAA
TTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTGATTACATCCCACGTTTTGTTTATGAAT
ACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCAACAATAGCCTATCCTTCTTTGACCTGA
GTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGAGTTCCAAACCCTATGAGTTTACTTTAC
AATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTGGGATTAAGTCATTCATCGCATACCTGA
TTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAATGATGTATGAGGCTGAACTGGAACATT
TGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTGTTACCCATTAGGGGTGATAACATTAAT
GGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAACCACATGTATAATATGCTACTTGGAAA
TGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTGACGACCTTAAAAAGGGTTAGATTGACA

>50465_50465_5_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000343231_ANO3_chr11_26574796_ENST00000525139_length(amino acids)=585AA_BP=28
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVF
LEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVM
EQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGH
PGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYL
EMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYK
YGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIP

--------------------------------------------------------------
>50465_50465_6_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000343231_ANO3_chr11_26574796_ENST00000537978_length(transcript)=1999nt_BP=106nt
GGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCCACCGCTGCGGTGATTTTCCTGCATG
GATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTGACAAGAACTGCTCCCTGCAGAGACTCA
ACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTGCTATTTTTATGGCAATATGGGCCACAG
TCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAATGGGAAGAAGAGGAGGAAACACTTCGTC
CCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAACCACATCAGCCTTCCTCAGACAAAGTCA
CTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGTTTGGAGTTGTGGTGTACCGCCTGGTTG
TCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACATCTGCTGCTGCTGTCTGTATCAATTTCA
TAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAATATCCTCGAACAGAATCAGAGTGGGAAA
ACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATATCGCTTTCTTTTTGGGAAGATTCGTAG
GCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTGGCTGTTTGATAGACCTCTGCCTCCAGA
TGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGATCCAGAACTGGTGGTCACGACATAAAA
TCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCATGAACCTTCATGGACTGATGGATGAGT
ACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCCCTCTTTTGGCTTTGTTAAACAATATCA
TTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAGCAACTGACATAGGTATCTGGCTTGGAA
TTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTGATTACATCCCACGTTTTGTTTATGAAT
ACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCAACAATAGCCTATCCTTCTTTGACCTGA
GTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGAGTTCCAAACCCTATGAGTTTACTTTAC
AATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTGGGATTAAGTCATTCATCGCATACCTGA
TTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAATGATGTATGAGGCTGAACTGGAACATT
TGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTGTTACCCATTAGGGGTGATAACATTAAT
GGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAACCACATGTATAATATGCTACTTGGAAA
TGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTGACGACCTTAAAAAGGGTTAGATTGACA

>50465_50465_6_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000343231_ANO3_chr11_26574796_ENST00000537978_length(amino acids)=585AA_BP=28
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVF
LEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVM
EQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGH
PGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYL
EMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYK
YGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIP

--------------------------------------------------------------
>50465_50465_7_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000522007_ANO3_chr11_26574796_ENST00000256737_length(transcript)=4634nt_BP=133nt
CCTTCCGCTTGCGCTGTGAGCTGAGGCGGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGG
CCACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTG
ACAAGAACTGCTCCCTGCAGAGACTCAACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTG
CTATTTTTATGGCAATATGGGCCACAGTCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAAT
GGGAAGAAGAGGAGGAAACACTTCGTCCCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAAC
CACATCAGCCTTCCTCAGACAAAGTCACTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGT
TTGGAGTTGTGGTGTACCGCCTGGTTGTCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACAT
CTGCTGCTGCTGTCTGTATCAATTTCATAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAAT
ATCCTCGAACAGAATCAGAGTGGGAAAACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATA
TCGCTTTCTTTTTGGGAAGATTCGTAGGCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTG
GCTGTTTGATAGACCTCTGCCTCCAGATGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGA
TCCAGAACTGGTGGTCACGACATAAAATCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCA
TGAACCTTCATGGACTGATGGATGAGTACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCC
CTCTTTTGGCTTTGTTAAACAATATCATTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAG
CAACTGACATAGGTATCTGGCTTGGAATTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTG
ATTACATCCCACGTTTTGTTTATGAATACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCA
ACAATAGCCTATCCTTCTTTGACCTGAGTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGA
GTTCCAAACCCTATGAGTTTACTTTACAATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTG
GGATTAAGTCATTCATCGCATACCTGATTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAA
TGATGTATGAGGCTGAACTGGAACATTTGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTG
TTACCCATTAGGGGTGATAACATTAATGGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAA
CCACATGTATAATATGCTACTTGGAAATGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTG
ACGACCTTAAAAAGGGTTAGATTGACATTGCAGGAAGCCAGGATGTAATTCTCAGAACCAGTCTCAGGGAGATATATGCTTGGAGAACTC
TGCCTTCCATCAACTGCAGTGTAATGGGAAAGAGGGTGGTGAGGTTTTGAAAGACAGATTTCCATGTAAATGTGCACAAGCCAGGCATGG
CTTAAAATATCATGCAGTCTTCACTCACATACTAATTTGACTTTGGAAAGTATGGTTGAGTTCAGATACTTATAAGAAATGACTTAAACA
AATCCTTGCCTTGGCTGCCAGAACTCTACATCCCTTCAGTTTACAGGTTGGTAGGAATTGCCCATGTCTCTTGCTGAGATTATGGATCTG
TGCCACAGGGGATTTATGCTGCTTTACATTGACTATGCAGTTGAAGAGTTGCACATCACCTTTAGTAGTCAAACCAAAAATCTAAGATTC
CAAAAAGAACAGCATTCATTGAAATAATATTCCATTGCATTGGCTACTTCAAGTCTCTTTTACCCCTGGCAGAGCCAGTTGCAGTGCAAT
TTTTTGTACTAAATGCCAATAAAGCCACATACTTATAAACTATGAATGGCTATTCTTATATAGTTTAGAACACAACTAATCCATACTTTA
TTGTGGAAGGCTGTTTTATAGTTTATTTAATTTTTTCTCTATGATTTATTACAACTCTCACGGAATATTAACTTGAAATGCTGTAAATAC
GTTGGTTTTCCTTGTCCCTTTGCACCTTGACAGTACGTAGTATACATTGTGGTTTATGCAGCTCTGACACCAGTTTTTGCTATTGTAATA
TGTTTATTCGGGAAAACTGAGGCCAGATGCTCTGCAACACTTACGCTTTTTCAACAATGTGCACTCTTACTCATGAACTAATGAAAATAA
TGCATGAATATAAATCTATATTATTTGCTAAAAAAAGAAAAAACATTTGTGTTTTAGTTTCTTTTTTCATGACTGAAGGGAGTTTTATGT
TATTATTTCTTCCATAGTTTTGTTTTGGTTTATTTTTAACAACGCTCTAGAAACAAAGTCAAATTAATCACAAAAGACATAATTTTGCTT
TGTTGTGGAATTTCTATTTCAACGTCAACTCTGTATCTATGAGTATGTCTGTTCCACAGACAGATGAGGCAGGAGTGATGGGGCACTCAA
GAAAGTTCAGAGGAGGCATAAGCTATGGAGGTTGGAAAGGAAGAAAGAGAAGAGCTGAAGTAAATGTATGGTAGAAATTAAGACGTTTCT
TTGCAAAACAAGGAAATCACACATATGCACACATACATATTTATGGTTACTATGATTGTTATTATTTGTCCAATCAAGCAAAGCACCATT
ATTTCTAACATATAAAAGACCAGATCAAACACAATGGAAATAAAGCTACTACATATATATGCCAGTATTTCTCTAGTAAGATTATGTTTC
TCTTACTAGAAAACTATTTTCTAAATATTAACACTGAAAATGTTTTGTTAGCTTTTCCTTCTTTCTCTCCAGAAGAAACATGGATAGATG
ATAGCTGTTTCATTGTTTGTTTTTGTCAAGCATATTCACTTTCCTCCTTGTCCTCTGATTCTGAGCAAAGGGCCTCAGACTCTGAACTTC
CCTCAAGTGCCGTTGTTATGTGAAACTCTTCCATTCAGATTCCAGAGAGGTTCTCATGCTCCCCCCCCTCCTTATTTGTAGCAATCGTAG
CAACTAATTCCACTAAGTACAAGGGAGTTTTTTACACTCCTCCATTTTTATAGCATCTGCATTTCTTTTTCTTTGTTAGGTACATGTATA
CACCTGCCTGAGTATAAATACTCTCTCTACCTAATAATAACATCAACCAACATCTTTTCCAAATTAGGGCCACAGAACAGCAACATTTGT
CTGACAGTAGTATAAAGAATAATGATAGCTCTATCCTTAAGAAGTATTTCCTTTCCTTTTTATATAGTCCCGTTAGGGTTTAAAACCATA
TTGATCAACTAGAAAGAAAAATATGAAAAGAGAAAAATATTTTAATTTAAAAATTGTAATACATTGATTTATAAAATGCCTTCTCTGATA
CTTTTGAAACAGATGTGAAAAACAGAAAAAGAAAAAATTGTCTGAAATGTTTATTTTGCAAAACAGTGCAATAGAATCTAGTTATGCCTT
CATCACTGTTGACAGTAAATACTGACAGCCCCTTGCAGTGTGTTAGTTTTAGATCACTCTGTTTTAGTTGAGAGAAATGTTTTATATCAT
GGTTTTTATATGAATACAAATTATTTCTCAAAGATTTATAGCACACACTATTCTCAGGAATTCTGTATTACATGAATGCTGCTTATATAT
TTTCATATTCTAACTTGTCTTTTCAAGCAAATAACTAATATATATGTGCATGCAGTCTGCCTTGACAAGTTGTTCCAAGCTGAAGAGCTT
TCACTGTACAATGTGTGGAAAATCACCATAGATCATGGCTGAAATAGTTTGTAATTGTCTGAGTCTGTGCACGTACTTTTAGATAAAATG
CTGCTGAGTGACTGCATGATGAGATACAACTTCTGAATGCTGCACATTCTTCCAAAATGATCCTTAGCACAATCTATTGTATGATGGAAT

>50465_50465_7_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000522007_ANO3_chr11_26574796_ENST00000256737_length(amino acids)=593AA_BP=36
MRCELRRCMCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIF
MAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGV
VVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAF
FLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNL
HGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYI
PRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIK

--------------------------------------------------------------
>50465_50465_8_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000522007_ANO3_chr11_26574796_ENST00000525139_length(transcript)=2026nt_BP=133nt
CCTTCCGCTTGCGCTGTGAGCTGAGGCGGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGG
CCACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTG
ACAAGAACTGCTCCCTGCAGAGACTCAACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTG
CTATTTTTATGGCAATATGGGCCACAGTCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAAT
GGGAAGAAGAGGAGGAAACACTTCGTCCCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAAC
CACATCAGCCTTCCTCAGACAAAGTCACTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGT
TTGGAGTTGTGGTGTACCGCCTGGTTGTCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACAT
CTGCTGCTGCTGTCTGTATCAATTTCATAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAAT
ATCCTCGAACAGAATCAGAGTGGGAAAACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATA
TCGCTTTCTTTTTGGGAAGATTCGTAGGCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTG
GCTGTTTGATAGACCTCTGCCTCCAGATGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGA
TCCAGAACTGGTGGTCACGACATAAAATCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCA
TGAACCTTCATGGACTGATGGATGAGTACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCC
CTCTTTTGGCTTTGTTAAACAATATCATTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAG
CAACTGACATAGGTATCTGGCTTGGAATTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTG
ATTACATCCCACGTTTTGTTTATGAATACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCA
ACAATAGCCTATCCTTCTTTGACCTGAGTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGA
GTTCCAAACCCTATGAGTTTACTTTACAATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTG
GGATTAAGTCATTCATCGCATACCTGATTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAA
TGATGTATGAGGCTGAACTGGAACATTTGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTG
TTACCCATTAGGGGTGATAACATTAATGGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAA
CCACATGTATAATATGCTACTTGGAAATGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTG

>50465_50465_8_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000522007_ANO3_chr11_26574796_ENST00000525139_length(amino acids)=593AA_BP=36
MRCELRRCMCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIF
MAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGV
VVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAF
FLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNL
HGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYI
PRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIK

--------------------------------------------------------------
>50465_50465_9_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000522007_ANO3_chr11_26574796_ENST00000537978_length(transcript)=2026nt_BP=133nt
CCTTCCGCTTGCGCTGTGAGCTGAGGCGGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGG
CCACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGCCAAGAAATTTGTAAAGCCACTGAAGTCTTTATGTGCCCTCTCTGTG
ACAAGAACTGCTCCCTGCAGAGACTCAACGACAGCTGTATCTATGCCAAGGTGACATATTTGTTCGATAATGGAGGGACAGTCTTCTTTG
CTATTTTTATGGCAATATGGGCCACAGTCTTCCTGGAGTTTTGGAAAAGGAGAAGGAGTATACTGACCTATACTTGGGACCTTATCGAAT
GGGAAGAAGAGGAGGAAACACTTCGTCCCCAGTTTGAAGCCAAGTATTACAAGATGGAGATTGTAAATCCCATCACGGGAAAACCTGAAC
CACATCAGCCTTCCTCAGACAAAGTCACTCGTCTTCTTGTTTCTGTCTCAGGAATATTCTTCATGATATCCTTGGTGATCACTGCAGTGT
TTGGAGTTGTGGTGTACCGCCTGGTTGTCATGGAACAGTTTGCATCATTCAAGTGGAATTTCATCAAACAATACTGGCAGTTTGCAACAT
CTGCTGCTGCTGTCTGTATCAATTTCATAATCATTATGTTGCTGAATCTTGCTTATGAAAAAATTGCTTACCTCCTCACCAATTTAGAAT
ATCCTCGAACAGAATCAGAGTGGGAAAACAGCTTCGCCCTGAAGATGTTCCTCTTCCAGTTTGTCAATTTAAACAGTTCCATCTTCTATA
TCGCTTTCTTTTTGGGAAGATTCGTAGGCCACCCAGGAAAATACAATAAACTTTTTGACCGGTGGAGACTGGAGGAATGTCATCCTAGTG
GCTGTTTGATAGACCTCTGCCTCCAGATGGGTGTCATCATGTTTTTGAAGCAAATATGGAACAACTTCATGGAACTAGGATACCCGTTGA
TCCAGAACTGGTGGTCACGACATAAAATCAAGCGGGGAATACATGATGCTTCCATACCTCAGTGGGAAAATGATTGGAATCTGCAGCCCA
TGAACCTTCATGGACTGATGGATGAGTACTTAGAAATGGTTTTGCAATTTGGTTTTACCACCATCTTTGTTGCGGCTTTTCCTCTAGCCC
CTCTTTTGGCTTTGTTAAACAATATCATTGAAATCAGGCTGGATGCATACAAATTTGTCACTCAATGGCGGAGGCCTTTGCCAGCCCGAG
CAACTGACATAGGTATCTGGCTTGGAATTCTCGAAGGAATCGGTATATTGGCTGTGATCACCAATGCATTTGTAATTGCTATTACTTCTG
ATTACATCCCACGTTTTGTTTATGAATACAAATATGGCCCCTGTGCAAATCATGTAGAACCAAGTGAAAATTGCTTGAAGGGATATGTCA
ACAATAGCCTATCCTTCTTTGACCTGAGTGAGCTTGGTATGGGAAAATCTGGTTATTGCAGGTACAGAGACTACAGAGGCCCGCCCTGGA
GTTCCAAACCCTATGAGTTTACTTTACAATACTGGCATATCCTTGCTGCTAGATTGGCCTTCATTATTGTGTTTGAGCACCTTGTTTTTG
GGATTAAGTCATTCATCGCATACCTGATTCCAGACGTACCAAAGGGTCTACATGACCGAATACGACGAGAGAAGTACTTAGTTCAAGAAA
TGATGTATGAGGCTGAACTGGAACATTTGCAACAACAACGGAGAAAAAGTGGTCAGCCTGTTCACCATGAATGGCCTTAGTTGACACCTG
TTACCCATTAGGGGTGATAACATTAATGGGAAGAAATGATGGCAACTTTGAATGCTAGGTGAAATCTAGGAGGAAGGCATACTTGGCAAA
CCACATGTATAATATGCTACTTGGAAATGTATCACAGCCATCTCTGGGATTTGAAATATCCAGACTTGTAGGGAAGAAAACAATGACTTG

>50465_50465_9_LYPLA1-ANO3_LYPLA1_chr8_55013468_ENST00000522007_ANO3_chr11_26574796_ENST00000537978_length(amino acids)=593AA_BP=36
MRCELRRCMCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIF
MAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGV
VVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAF
FLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNL
HGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYI
PRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LYPLA1-ANO3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LYPLA1-ANO3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LYPLA1-ANO3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource