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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LYRM1-PDE3A (FusionGDB2 ID:50478)

Fusion Gene Summary for LYRM1-PDE3A

check button Fusion gene summary
Fusion gene informationFusion gene name: LYRM1-PDE3A
Fusion gene ID: 50478
HgeneTgene
Gene symbol

LYRM1

PDE3A

Gene ID

57149

5139

Gene nameLYR motif containing 1phosphodiesterase 3A
SynonymsA211C6.1CGI-PDE|CGI-PDE A|CGI-PDE-A|HTNB
Cytomap

16p12.3

12p12.2

Type of geneprotein-codingprotein-coding
DescriptionLYR motif-containing protein 1cGMP-inhibited 3',5'-cyclic phosphodiesterase AcAMP phosphodiesterase, myocardial cGMP-inhibitedcyclic GMP-inhibited phosphodiesterase Aphosphodiesterase 3A, cGMP-inhibited
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000219168, ENST00000396052, 
ENST00000439021, ENST00000567954, 
ENST00000568663, ENST00000569023, 
ENST00000412082, ENST00000562740, 
ENST00000564457, 		ENST00000544307, 
ENST00000359062, 
Fusion gene scores* DoF score3 X 3 X 2=189 X 12 X 6=648
# samples 313
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LYRM1 [Title/Abstract] AND PDE3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLYRM1(20927036)-PDE3A(20709594), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDE3A

GO:0071321

cellular response to cGMP

17704206


check buttonFusion gene breakpoints across LYRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8210-01ALYRM1chr16

20927036

+PDE3Achr12

20709594

+


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Fusion Gene ORF analysis for LYRM1-PDE3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000219168ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
5CDS-intronENST00000396052ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
5CDS-intronENST00000439021ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
5CDS-intronENST00000567954ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
5CDS-intronENST00000568663ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
5CDS-intronENST00000569023ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
In-frameENST00000219168ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
In-frameENST00000396052ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
In-frameENST00000439021ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
In-frameENST00000567954ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
In-frameENST00000568663ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
In-frameENST00000569023ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
intron-3CDSENST00000412082ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
intron-3CDSENST00000562740ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
intron-3CDSENST00000564457ENST00000359062LYRM1chr16

20927036

+PDE3Achr12

20709594

+
intron-intronENST00000412082ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
intron-intronENST00000562740ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+
intron-intronENST00000564457ENST00000544307LYRM1chr16

20927036

+PDE3Achr12

20709594

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000568663LYRM1chr1620927036+ENST00000359062PDE3Achr1220709594+70765002992965888
ENST00000439021LYRM1chr1620927036+ENST00000359062PDE3Achr1220709594+70364602592925888
ENST00000569023LYRM1chr1620927036+ENST00000359062PDE3Achr1220709594+71355594003024874
ENST00000219168LYRM1chr1620927036+ENST00000359062PDE3Achr1220709594+71045283062993895
ENST00000567954LYRM1chr1620927036+ENST00000359062PDE3Achr1220709594+6826250912715874
ENST00000396052LYRM1chr1620927036+ENST00000359062PDE3Achr1220709594+71355594003024874

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000568663ENST00000359062LYRM1chr1620927036+PDE3Achr1220709594+0.000136630.9998634
ENST00000439021ENST00000359062LYRM1chr1620927036+PDE3Achr1220709594+0.0001301370.9998698
ENST00000569023ENST00000359062LYRM1chr1620927036+PDE3Achr1220709594+0.0001402140.9998598
ENST00000219168ENST00000359062LYRM1chr1620927036+PDE3Achr1220709594+0.0001367350.99986327
ENST00000567954ENST00000359062LYRM1chr1620927036+PDE3Achr1220709594+0.0001272580.9998727
ENST00000396052ENST00000359062LYRM1chr1620927036+PDE3Achr1220709594+0.0001370390.9998629

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Fusion Genomic Features for LYRM1-PDE3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LYRM1chr1620927036+PDE3Achr1220709593+1.32E-050.99998677
LYRM1chr1620927036+PDE3Achr1220709593+1.32E-050.99998677

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LYRM1-PDE3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:20927036/chr12:20709594)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE3Achr16:20927036chr12:20709594ENST000003590620161040_10453201142.0Compositional biasNote=Poly-Glu
TgenePDE3Achr16:20927036chr12:20709594ENST000003590620161121_11253201142.0Compositional biasNote=Poly-Glu
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016440_4453201142.0Compositional biasNote=Poly-Thr
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016870_8733201142.0Compositional biasNote=Poly-Ala
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016674_10933201142.0DomainPDEase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016288_2913201142.0Compositional biasNote=Poly-Arg
TgenePDE3Achr16:20927036chr12:20709594ENST0000035906201695_983201142.0Compositional biasNote=Poly-Ala
TgenePDE3Achr16:20927036chr12:20709594ENST0000035906201699_1023201142.0Compositional biasNote=Poly-Glu
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016130_1503201142.0TransmembraneHelical
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016160_1803201142.0TransmembraneHelical
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016185_2053201142.0TransmembraneHelical
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016210_2303201142.0TransmembraneHelical
TgenePDE3Achr16:20927036chr12:20709594ENST00000359062016232_2523201142.0TransmembraneHelical
TgenePDE3Achr16:20927036chr12:20709594ENST0000035906201661_813201142.0TransmembraneHelical


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Fusion Gene Sequence for LYRM1-PDE3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50478_50478_1_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000219168_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=7104nt_BP=528nt
GGTTTGGTCCGGCCTGGCCTACTGGACCAGCCTGTGCTCGGTCGGCCACGGCTCTGCTGGGCTCCTGGCGCCGCCTCCTCCCAGCCCGCC
GCGGGCTGCGCGCTTCTGTGGGTGGGGGAAGGCAGGACTGACGCAGAAGAGTACCCAGAGAAGGAGAAGCCAGCAAAGGAGACGACACAG
ACAAGACCTCAGAGATCAAAGGAAGAGGCCCCTTAATATCCTGGAATAATGGGACCCATCCCCGTAATCAGTGAATCTCATCCACCCGCT
TGCCAGCTTCTACCCGCAGCAAGTAGAAGCTAAGTCCTGGCTCAAATCTCTTCCCTCCCTCCCTCTCCCAGCTGTCAGTGCTTTTGGACT
TGTGCTCAGATGACAACGGCAACACGACAAGAAGTCCTTGGCCTCTACCGCAGCATTTTCAGGCTTGCGAGGAAATGGCAGGCGACATCA
GGGCAGATGGAAGACACCATCAAAGAAAAACAGTACATACTAAATGAAGCCAGAACGCTGTTCCGGAAAAACAAAAATCTCATGGGGCAT
TCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGAACCAGTATTACTGTGGACATCGCCGTCATGGGCGAGGCCCAC
GGCCTCATTACCGACCTCCTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTGCTCAGCACACAG
CTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTCACTTCGCTCAGTGAAAACTATACCTGTTCTGACTCTGAAGAGAGCTCT
GAAAAAGACAAGCTTGCTATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACTTGGACCACCACC
ACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGAGACCGCAGCACCAGCATCAAACTGCAGGAAGCACCTTCATCC
AGTCCTGATTCTTGGAATAATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCTGCAGCTAACCAT
GTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCACCTCTTTCATCGCCCTGCTCCTCACCTCTCCAAGGGACTCCT
GCCAGCAGCCTGGTCAGCAAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGTTCTCACAGGGCC
TTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACTCCACCTGTTATATGTAGCAGCTGTGGCAGACCATATTCCCAA
GGGAATCCTGCTGATGAGCCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTAGAACAGATGACACTGCTCAAGTTACCTCTGAT
TATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAAGATGAAACAGAGTGCCTGAGAGAGCCTCTGAGGAAAGCATCG
GCTTGCAGCACCTATGCTCCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGATAACCTGGACTCA
ATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTGGAAAATATAGGAAGAAAATGTGGCCGTATTCTTAGTCAGGTA
TCTTACAGACTTTTTGAAGACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCATGCTTTGGAGATT
GGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTTTTACATGCTGTTTGGTATCTTACTACACAGCCTATTCCAGGC
CTCTCAACTGTGATTAATGATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGGACATATGGGATATGTATTCTCA
AAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAATATCCCTGCCTTGGAGTTGATGGCGCTGTATGTGGCTGCAGCC
ATGCACGATTATGATCATCCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAACGATCGTTCAGTT
TTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGGCCAGAGTATAACTTCTTAATTAACCTTGACCATGTGGAATTT
AAGCATTTCCGTTTCCTTGTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTTAATGGCAAGGTA
AATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTGGTTTGTCAAATGTGTATAAAGTTGGCTGATATCAATGGTCCA
GCTAAATGTAAAGAACTCCATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCCAGCCTTGGATTA
CCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTTCAGGAATCCTTCATCTCTCACATTGTGGGGCCTCTGTGCAAC
TCCTATGATTCAGCAGGACTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAAGAAGAGGAGGAA
GAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCTCCAAAAAAGAAGACTTTCAAAAGGAGAAAAATCTACTGCCAA
ATAACTCAGCACCTCTTACAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAAAATCAATCCCTG
GACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAGGAAGAAGAAGAAGAGAAAGGGAAACCAAGAGGCGAGGAGATA
CCAACCCAAAAGCCAGACCAGTGACAATGGATAGAATGGGCTGTGTTTCCAAACAGATTGACTTGTCAAAGACTCTCTTCAAGCCAGCAC
AACATTTAGACACAACACTGTAGAAATTTGAGATGGGCAAATGGCTATTGCATTTTGGGATTCTTCGCATTTTGTGTGTATATTTTTACA
GTGAGGTACATTGTTAAAAACTTTTTGCTCAAAGAAGCTTTCACATTGCAACACCAGCTTCTAAGGATTTTTTAAGGAGGGAATATATAT
GTGTGTGTGTATATAAGCTCCCACATAGATACATGTAAAACATATTCACACCCATGCACGCACACACATACACACTGAAGGCCACGATTG
CTGGCTCCACAATTTAGTAACATTTATATTAAGATATATATATAGTGGTCACTGTGATATAATAAATCATAAAGGAAACCAAATCACAAA
GGAGATGGTGTGGCTTAGCAAGGAAACAGTGCAGGAAATGTAGGTTACCAACTAAGCAGCTTTTGCTCTTAGTACTGAGGGATGAAAGTT
CCAGAGCATTATTTGAATTCTGATACATCCTGCCAACACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAAGAGA
GACAGAAGGGAATGGTTTGAGAGGGTGCTTGTGTGCATGTGTGTGCATATGTAAAGAGATTTTTGTGGTTTAAGTAACTCAGAATAGCTG
TAGCAAATGACTGAATACATGTGAACAAACAGAAGGAAGTTCACTCTGGAGTGTCTTTGGGAGGCAGCCATTCCAAATGCCCTCCTCCAT
TTAGCTTCAATAAAGGGCCTTTTGCTGATGGAGGGCACTCAAGGGCTGGGTGAGAGGGCCACGTGTTTGGTATTACATTACTGCTATGCA
CCACTTGAAGGAGCTCTATCACCAGCCTCAAACCCGAAAGACTGAGGCATTTTCCAGTCTACTTGCCTAATGAATGTATAGGAACTGTCT
ATGAGTATGGATGTCACTCAACTAAGATCAAATCACCATTTAAGGGGATGGCATTCTTTATACCTAAACACCTAAGAGCTGAAGTCAGGT
CTTTTAATCAGGTTAGAATTCTAAATGATGCCAGAGAAGGCTTGGGAAATTGTACTTCAGCGTGATAGCCTGTGTCTTCTTAATTTGCTG
CAAAATATGTGGTAGAGAAAGAAAAGGAAACAGAAAAATCACTCTGGGTTATATAGCAAGAGATGAAGGAGAATATTTCAACACAGGGTT
TTTGTGTTGACATAGGAAAAGCCTGATTCTTGGCAACTGTTGTAGTTTGTCTTTCAGGGGTGAAGGTCCCACTGACAACCCCTGTTGTGG
TGTTCCACACGCTGTTTGTTGGGGTAGCTTCCATCGGCAGTCTGGCCCATTGTCAGTCATGCTTCTTCTGGCCGGGGAGATTATAGAGAG
ATTGTTTGAAGATTGGGTTATTATTGAAAGTCTTTTTTTTTGTTTGTTTTGTTTTGGTTTGTTTGTTTATCTACACTTGTTTATGCTGTG
AGCCAAACCTCTATTTAAAAAGTTGATACTCACTTTCAATATTTTATTTCATATTATTATATATGTCATGATAGTTATCTTGATGTAAAT
ATGAAGATTTTTTTGTTTCTGTAGATAGTAAACTCTTTTTTTAAAAAAGGAAAAGGGAAACATTTTTATAAAGTTATATTTTAATCACCA
TTTTTATACATTGTAGTTCTCTCCAAGCCCAGTAAGAGAATGATGATTCATTTGCATGGAGGTCGATGGACAACCAATCATCTACCTTTT
CTAATTTAAATGATAATCTGATATAGTTTTATTGCCAGTTAAATGAGGATGCTGCAAAGCATGTTTTTTCACTAGTAACTTTTGCTAACT
GAATGAATTCTGGGTCCATATCTCCCAGATGAAAAACTGTTAACCAATACCATATTTTATAGTTGGTGTCCATTTCTTTCCAACACTGTT
TGTTATGATTCTTCCTTGAGTACTTATATACAGACCTGCTCATTATCTAAACAATCTTACCTTCTAAGTAAACCTTGATTGTGATTTCCA
GTTTTTATTTTCTCTGACGTAGTAGAAAGGAATGTTTACATTAAAAATACTTTTGTTTCTCATAAATGGATATTGTACTCCCCCCTTTCA
AAGCATTATTTTACAATAATTCATGGCATTTTAAAAAATAAGGCAAAGATAATACGACAAAAAATATACATGGTTTCAAGGCAAATTCTC
CAATAAGTTGGAAAATGTAAAAAGGATCAAGTGGATGCAGCCTCTACCTAAATAATTAAAATATATTTCAGTATATTTCTGAATTAACAC
CAGGTCTTCATTATTTAGAACTTACTAAATTGTTTTCATTTTCTTAGTTTTACCTGTGTATCTCCATGTTTGCAAAAATTACTATAAGTC
AAATTTTGCCAGTGAATTTAACTATTTTTCTTTCCTTGCAATTAAGGGGAAAAAAGCATTTATCTTATCTTCTCATACCCCTTGCATCTA
AGTACTTAGCAAAGTCAATATTTTCCCATTTTCCAAATGCGTCCATCTCTAACATAAATATTAATTGAACATAGAGCTATGTTTGGAGTG
AGTGGACTGGCAGGACAGTTGGAAGTCCATCACAGTCTATTGACAGTTTCATCAAAGCTGTATAGTCCAACTAGTGGGGCAGCTTGGCTA
CTATGGTGGAAGTCTCAGCAAACTGCCTGGTTTTGTTTGTTTGTTTTGTTTTAAGGTACAGGAAATAAGAGGAATAATAGTGGCCAAAGC
AATTAGAACATCTTCATTCCAGAACTGTGTTCAGCAATCCAGGCAGATTGATACATTTTTCTTTAAAAATAAATTGCTATTACAGCTAGA
CGTCAATTGGGATAAATAAAGGGATGAAGATCCACTAAGTTTGTGACTTTCATACACACCCAGTACATCTCAAAGGATGCTAAGGGACAT
TTTCTGCCAGTAGAGTTCTCCCCCTTTTTGGTGACAGCAATATTATTATGTTCACATCTAACTCCAGAGCTTACTTCCTGTGGTGCCAAT
GTATTTGTTGCAATTTACTACATTTTTATATGAGCCTATTTATAGGTGCCATTAAACTCAGGTCTTTCAAATGAAAGAGTTTCTAGCCCA
CTTAGGGAAAAAGATAATTGTTTAGAAAACCATAAAATCAATGGTAGGAAAAGTTGGAACTGGTTACCTGGATGCCATGGTTCTCTGTTA
AATAAAGTAAGAGACCAGGTGTATTCTGAGTGTCATCAGTGTTATTTTCAGCATGCTAATAAATGTCTTTCCGGTTATATATCTATCTAA
ATTAACCTTTAAAATATTGGTTTCCTTGATAAAAGCACCACTTTTGCTTTTGTTAGCTGTAATATTTTTTGTCATTTAGATAAGACCTGG
TTTGGCTCTCAATAAAAGATGAAGACAGTAGCTCTGTACAGGGATATATCTATATTAGTCTTCATCTGATGAATGAAGAAATTTTCTCAT
ATTATGTTCAAGAAAGTATTTACTTCCTAAAAATAGAATTCCCGATTCTGTCTATTTTGGTTGAATACCAGAACAAATCTTTCCGTTGCA
ATCCCAGTAAAACGAAAGAAAAGGAATATCTTACAGACTGTTCATATTAGATGTATGTAGACTGTTAATTTGCAATTTCCCCATATTTCC
TGCCTATCTTACCCAGATAACTTTCTTTGAAGGTAAAAGCTGTGCAAAAGGCATGAGACTCAGGCCTACTCTTTGTTTAAATGATGGAAA
AATATAAATTATTTTCTAAGTAATAAAAGTATAAAAATTATCATTATAAATAAAGTCTAAAGTTTGAAATTATTAATTTATAAAAGTGAA
CTAATTGTGTGATTATCAAATCCTGATTAATGAGAAGTGAATAATCTAAAAATCATTTATATTCTACTGTGGGAGGTATTCTTGGTGCTT
CCATGTCAGTATCGGGCTCTCCATTGTCCTCATCATTTATAGTACTTCTAAAATAATAATGGAAACCTCAATAAGGGTCTTGTCCTCTTC

>50478_50478_1_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000219168_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=895AA_BP=74
MAQISSLPPSPSCQCFWTCAQMTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLMGHSEWDHKRGPRGS
QSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLR
RSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGAL
AKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSG
VATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPI
FDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTS
DSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNL
FMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTD
GIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCE

--------------------------------------------------------------
>50478_50478_2_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000396052_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=7135nt_BP=559nt
GCCTGGTGTGGGGACGCTCAGGTGCCGGCGTGGGGCCCCCTCGGAGGCTGTGAATCTTTTGGACCCCCGAATGTAAATGGGAGATGAGAG
TACCCAGAGAAGGAGAAGCCAGCAAAGGAGACGACACAGACAAGACCTCAGAGATCAAAGGAAGAGGCCCCTTAATATCCTGGAATAATG
GGACCCATCCCCGTAATCAGTGAATCTCATCCACCCGCTTGCCAGCTTCTACCCGCAGCAAGTAGAAGCTAAGTCCTGGCTCAAATCTCT
TCCCTCCCTCCCTCTCCCAGCTGTCAGTGCTTTTGGACTTGTGCTCAGGTGAAGTAGTATTTGAAGCTTTTCATCAGTTGGCTCATTCTT
TACTCAAGAATAAACCTCAAGAAACGTCATCAGGGTCAGAATGACAACGGCAACACGACAAGAAGTCCTTGGCCTCTACCGCAGCATTTT
CAGGCTTGCGAGGAAATGGCAGGCGACATCAGGGCAGATGGAAGACACCATCAAAGAAAAACAGTACATACTAAATGAAGCCAGAACGCT
GTTCCGGAAAAACAAAAATCTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGAACCAGTATTAC
TGTGGACATCGCCGTCATGGGCGAGGCCCACGGCCTCATTACCGACCTCCTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTT
GAGAGCCGTGAGCAACTTGCTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTCACTTCGCTCAGTGAAAA
CTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCTATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTT
GAGACGAGTTTCTTCCACTTGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGAGACCGCAGCAC
CAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAATAATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTAC
TTCATCCTATGCTATTTCTGCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCACCTCTTTCATC
GCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGCAAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAAC
TGCCAAACAAAGCCTAGGTTCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACTCCACCTGTTAT
ATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAGCCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTAG
AACAGATGACACTGCTCAAGTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAAGATGAAACAGA
GTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCTCCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCC
CGAACCTCTTGTCATGGATAACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTGGAAAATATAGG
AAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAAGACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGA
ATTTATGAATTATTTTCATGCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTTTTACATGCTGT
TTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAATGATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATT
TACACATGGACATATGGGATATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAATATCCCTGCCTT
GGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCATCCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCC
TCAGGCGGTGCTATATAACGATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGGCCAGAGTATAA
CTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTTGTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTT
TGACTTCGTAGCCAAATTTAATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTGGTTTGTCAAAT
GTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTCCATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGA
ACAGGGTGATGAAGAGGCCAGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTTCAGGAATCCTT
CATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGACTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGG
AGATACTGATGACCCAGAAGAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCTCCAAAAAAGAA
GACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTACAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCA
ACGGTTGGCAGGCATAGAAAATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAGGAAGAAGAAGA
AGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGACCAGTGACAATGGATAGAATGGGCTGTGTTTCCAAACAGATT
GACTTGTCAAAGACTCTCTTCAAGCCAGCACAACATTTAGACACAACACTGTAGAAATTTGAGATGGGCAAATGGCTATTGCATTTTGGG
ATTCTTCGCATTTTGTGTGTATATTTTTACAGTGAGGTACATTGTTAAAAACTTTTTGCTCAAAGAAGCTTTCACATTGCAACACCAGCT
TCTAAGGATTTTTTAAGGAGGGAATATATATGTGTGTGTGTATATAAGCTCCCACATAGATACATGTAAAACATATTCACACCCATGCAC
GCACACACATACACACTGAAGGCCACGATTGCTGGCTCCACAATTTAGTAACATTTATATTAAGATATATATATAGTGGTCACTGTGATA
TAATAAATCATAAAGGAAACCAAATCACAAAGGAGATGGTGTGGCTTAGCAAGGAAACAGTGCAGGAAATGTAGGTTACCAACTAAGCAG
CTTTTGCTCTTAGTACTGAGGGATGAAAGTTCCAGAGCATTATTTGAATTCTGATACATCCTGCCAACACTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTGTGAAAGAGAGACAGAAGGGAATGGTTTGAGAGGGTGCTTGTGTGCATGTGTGTGCATATGTAAAGAGA
TTTTTGTGGTTTAAGTAACTCAGAATAGCTGTAGCAAATGACTGAATACATGTGAACAAACAGAAGGAAGTTCACTCTGGAGTGTCTTTG
GGAGGCAGCCATTCCAAATGCCCTCCTCCATTTAGCTTCAATAAAGGGCCTTTTGCTGATGGAGGGCACTCAAGGGCTGGGTGAGAGGGC
CACGTGTTTGGTATTACATTACTGCTATGCACCACTTGAAGGAGCTCTATCACCAGCCTCAAACCCGAAAGACTGAGGCATTTTCCAGTC
TACTTGCCTAATGAATGTATAGGAACTGTCTATGAGTATGGATGTCACTCAACTAAGATCAAATCACCATTTAAGGGGATGGCATTCTTT
ATACCTAAACACCTAAGAGCTGAAGTCAGGTCTTTTAATCAGGTTAGAATTCTAAATGATGCCAGAGAAGGCTTGGGAAATTGTACTTCA
GCGTGATAGCCTGTGTCTTCTTAATTTGCTGCAAAATATGTGGTAGAGAAAGAAAAGGAAACAGAAAAATCACTCTGGGTTATATAGCAA
GAGATGAAGGAGAATATTTCAACACAGGGTTTTTGTGTTGACATAGGAAAAGCCTGATTCTTGGCAACTGTTGTAGTTTGTCTTTCAGGG
GTGAAGGTCCCACTGACAACCCCTGTTGTGGTGTTCCACACGCTGTTTGTTGGGGTAGCTTCCATCGGCAGTCTGGCCCATTGTCAGTCA
TGCTTCTTCTGGCCGGGGAGATTATAGAGAGATTGTTTGAAGATTGGGTTATTATTGAAAGTCTTTTTTTTTGTTTGTTTTGTTTTGGTT
TGTTTGTTTATCTACACTTGTTTATGCTGTGAGCCAAACCTCTATTTAAAAAGTTGATACTCACTTTCAATATTTTATTTCATATTATTA
TATATGTCATGATAGTTATCTTGATGTAAATATGAAGATTTTTTTGTTTCTGTAGATAGTAAACTCTTTTTTTAAAAAAGGAAAAGGGAA
ACATTTTTATAAAGTTATATTTTAATCACCATTTTTATACATTGTAGTTCTCTCCAAGCCCAGTAAGAGAATGATGATTCATTTGCATGG
AGGTCGATGGACAACCAATCATCTACCTTTTCTAATTTAAATGATAATCTGATATAGTTTTATTGCCAGTTAAATGAGGATGCTGCAAAG
CATGTTTTTTCACTAGTAACTTTTGCTAACTGAATGAATTCTGGGTCCATATCTCCCAGATGAAAAACTGTTAACCAATACCATATTTTA
TAGTTGGTGTCCATTTCTTTCCAACACTGTTTGTTATGATTCTTCCTTGAGTACTTATATACAGACCTGCTCATTATCTAAACAATCTTA
CCTTCTAAGTAAACCTTGATTGTGATTTCCAGTTTTTATTTTCTCTGACGTAGTAGAAAGGAATGTTTACATTAAAAATACTTTTGTTTC
TCATAAATGGATATTGTACTCCCCCCTTTCAAAGCATTATTTTACAATAATTCATGGCATTTTAAAAAATAAGGCAAAGATAATACGACA
AAAAATATACATGGTTTCAAGGCAAATTCTCCAATAAGTTGGAAAATGTAAAAAGGATCAAGTGGATGCAGCCTCTACCTAAATAATTAA
AATATATTTCAGTATATTTCTGAATTAACACCAGGTCTTCATTATTTAGAACTTACTAAATTGTTTTCATTTTCTTAGTTTTACCTGTGT
ATCTCCATGTTTGCAAAAATTACTATAAGTCAAATTTTGCCAGTGAATTTAACTATTTTTCTTTCCTTGCAATTAAGGGGAAAAAAGCAT
TTATCTTATCTTCTCATACCCCTTGCATCTAAGTACTTAGCAAAGTCAATATTTTCCCATTTTCCAAATGCGTCCATCTCTAACATAAAT
ATTAATTGAACATAGAGCTATGTTTGGAGTGAGTGGACTGGCAGGACAGTTGGAAGTCCATCACAGTCTATTGACAGTTTCATCAAAGCT
GTATAGTCCAACTAGTGGGGCAGCTTGGCTACTATGGTGGAAGTCTCAGCAAACTGCCTGGTTTTGTTTGTTTGTTTTGTTTTAAGGTAC
AGGAAATAAGAGGAATAATAGTGGCCAAAGCAATTAGAACATCTTCATTCCAGAACTGTGTTCAGCAATCCAGGCAGATTGATACATTTT
TCTTTAAAAATAAATTGCTATTACAGCTAGACGTCAATTGGGATAAATAAAGGGATGAAGATCCACTAAGTTTGTGACTTTCATACACAC
CCAGTACATCTCAAAGGATGCTAAGGGACATTTTCTGCCAGTAGAGTTCTCCCCCTTTTTGGTGACAGCAATATTATTATGTTCACATCT
AACTCCAGAGCTTACTTCCTGTGGTGCCAATGTATTTGTTGCAATTTACTACATTTTTATATGAGCCTATTTATAGGTGCCATTAAACTC
AGGTCTTTCAAATGAAAGAGTTTCTAGCCCACTTAGGGAAAAAGATAATTGTTTAGAAAACCATAAAATCAATGGTAGGAAAAGTTGGAA
CTGGTTACCTGGATGCCATGGTTCTCTGTTAAATAAAGTAAGAGACCAGGTGTATTCTGAGTGTCATCAGTGTTATTTTCAGCATGCTAA
TAAATGTCTTTCCGGTTATATATCTATCTAAATTAACCTTTAAAATATTGGTTTCCTTGATAAAAGCACCACTTTTGCTTTTGTTAGCTG
TAATATTTTTTGTCATTTAGATAAGACCTGGTTTGGCTCTCAATAAAAGATGAAGACAGTAGCTCTGTACAGGGATATATCTATATTAGT
CTTCATCTGATGAATGAAGAAATTTTCTCATATTATGTTCAAGAAAGTATTTACTTCCTAAAAATAGAATTCCCGATTCTGTCTATTTTG
GTTGAATACCAGAACAAATCTTTCCGTTGCAATCCCAGTAAAACGAAAGAAAAGGAATATCTTACAGACTGTTCATATTAGATGTATGTA
GACTGTTAATTTGCAATTTCCCCATATTTCCTGCCTATCTTACCCAGATAACTTTCTTTGAAGGTAAAAGCTGTGCAAAAGGCATGAGAC
TCAGGCCTACTCTTTGTTTAAATGATGGAAAAATATAAATTATTTTCTAAGTAATAAAAGTATAAAAATTATCATTATAAATAAAGTCTA
AAGTTTGAAATTATTAATTTATAAAAGTGAACTAATTGTGTGATTATCAAATCCTGATTAATGAGAAGTGAATAATCTAAAAATCATTTA
TATTCTACTGTGGGAGGTATTCTTGGTGCTTCCATGTCAGTATCGGGCTCTCCATTGTCCTCATCATTTATAGTACTTCTAAAATAATAA
TGGAAACCTCAATAAGGGTCTTGTCCTCTTCTGTCATCCTAACCCTGATTCTAGTTTAATGCCTTTCCTGACTTATATGCCATTTGTAAA

>50478_50478_2_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000396052_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=874AA_BP=53
MTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLI
TDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSA
TGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASS
LVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYET
NNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYR
LFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTY
NVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHF
RFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPIS
PFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQ

--------------------------------------------------------------
>50478_50478_3_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000439021_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=7036nt_BP=460nt
TTTCTGGAAACGACGGCGGCCCGGCGGGTCCAAACCACCTACCATCCCCGCTCGCGTTTCCAGGCTCCCTACCCCCGCCGCCGCCGCCTC
TTCTTCCACCACTGCCACCGCCTCCTCTTCATCTGCGGCCCACCGGCGGCGGCCGCCCCGAAGCCCCGCCCCCTCCATCGCCTCCTGCAT
CATCACTTCCGGTAACCCCGCCGGCCGCCAGCTCCAGGAGGGAGAATGGGAGAGGGGCAAGGAGGGAACGAGTGGAAGATTGCGTCACGA
CGCACATAAAGACGTACGAAGCCGTCGCCAAATGACAACGGCAACACGACAAGAAGTCCTTGGCCTCTACCGCAGCATTTTCAGGCTTGC
GAGGAAATGGCAGGCGACATCAGGGCAGATGGAAGACACCATCAAAGAAAAACAGTACATACTAAATGAAGCCAGAACGCTGTTCCGGAA
AAACAAAAATCTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGAACCAGTATTACTGTGGACAT
CGCCGTCATGGGCGAGGCCCACGGCCTCATTACCGACCTCCTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGT
GAGCAACTTGCTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTCACTTCGCTCAGTGAAAACTATACCTG
TTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCTATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGT
TTCTTCCACTTGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGAGACCGCAGCACCAGCATCAA
ACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAATAATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTA
TGCTATTTCTGCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCACCTCTTTCATCGCCCTGCTC
CTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGCAAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACA
AAGCCTAGGTTCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACTCCACCTGTTATATGTAGCAG
CTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAGCCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTAGAACAGATGA
CACTGCTCAAGTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAAGATGAAACAGAGTGCCTGAG
AGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCTCCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCT
TGTCATGGATAACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTGGAAAATATAGGAAGAAAATG
TGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAAGACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAA
TTATTTTCATGCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTTTTACATGCTGTTTGGTATCT
TACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAATGATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGG
ACATATGGGATATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAATATCCCTGCCTTGGAGTTGAT
GGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCATCCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGT
GCTATATAACGATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGGCCAGAGTATAACTTCTTAAT
TAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTTGTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGT
AGCCAAATTTAATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTGGTTTGTCAAATGTGTATAAA
GTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTCCATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGA
TGAAGAGGCCAGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTTCAGGAATCCTTCATCTCTCA
CATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGACTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGA
TGACCCAGAAGAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCTCCAAAAAAGAAGACTTTCAA
AAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTACAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGC
AGGCATAGAAAATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAGGAAGAAGAAGAAGAGAAAGG
GAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGACCAGTGACAATGGATAGAATGGGCTGTGTTTCCAAACAGATTGACTTGTCA
AAGACTCTCTTCAAGCCAGCACAACATTTAGACACAACACTGTAGAAATTTGAGATGGGCAAATGGCTATTGCATTTTGGGATTCTTCGC
ATTTTGTGTGTATATTTTTACAGTGAGGTACATTGTTAAAAACTTTTTGCTCAAAGAAGCTTTCACATTGCAACACCAGCTTCTAAGGAT
TTTTTAAGGAGGGAATATATATGTGTGTGTGTATATAAGCTCCCACATAGATACATGTAAAACATATTCACACCCATGCACGCACACACA
TACACACTGAAGGCCACGATTGCTGGCTCCACAATTTAGTAACATTTATATTAAGATATATATATAGTGGTCACTGTGATATAATAAATC
ATAAAGGAAACCAAATCACAAAGGAGATGGTGTGGCTTAGCAAGGAAACAGTGCAGGAAATGTAGGTTACCAACTAAGCAGCTTTTGCTC
TTAGTACTGAGGGATGAAAGTTCCAGAGCATTATTTGAATTCTGATACATCCTGCCAACACTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGAAAGAGAGACAGAAGGGAATGGTTTGAGAGGGTGCTTGTGTGCATGTGTGTGCATATGTAAAGAGATTTTTGTGG
TTTAAGTAACTCAGAATAGCTGTAGCAAATGACTGAATACATGTGAACAAACAGAAGGAAGTTCACTCTGGAGTGTCTTTGGGAGGCAGC
CATTCCAAATGCCCTCCTCCATTTAGCTTCAATAAAGGGCCTTTTGCTGATGGAGGGCACTCAAGGGCTGGGTGAGAGGGCCACGTGTTT
GGTATTACATTACTGCTATGCACCACTTGAAGGAGCTCTATCACCAGCCTCAAACCCGAAAGACTGAGGCATTTTCCAGTCTACTTGCCT
AATGAATGTATAGGAACTGTCTATGAGTATGGATGTCACTCAACTAAGATCAAATCACCATTTAAGGGGATGGCATTCTTTATACCTAAA
CACCTAAGAGCTGAAGTCAGGTCTTTTAATCAGGTTAGAATTCTAAATGATGCCAGAGAAGGCTTGGGAAATTGTACTTCAGCGTGATAG
CCTGTGTCTTCTTAATTTGCTGCAAAATATGTGGTAGAGAAAGAAAAGGAAACAGAAAAATCACTCTGGGTTATATAGCAAGAGATGAAG
GAGAATATTTCAACACAGGGTTTTTGTGTTGACATAGGAAAAGCCTGATTCTTGGCAACTGTTGTAGTTTGTCTTTCAGGGGTGAAGGTC
CCACTGACAACCCCTGTTGTGGTGTTCCACACGCTGTTTGTTGGGGTAGCTTCCATCGGCAGTCTGGCCCATTGTCAGTCATGCTTCTTC
TGGCCGGGGAGATTATAGAGAGATTGTTTGAAGATTGGGTTATTATTGAAAGTCTTTTTTTTTGTTTGTTTTGTTTTGGTTTGTTTGTTT
ATCTACACTTGTTTATGCTGTGAGCCAAACCTCTATTTAAAAAGTTGATACTCACTTTCAATATTTTATTTCATATTATTATATATGTCA
TGATAGTTATCTTGATGTAAATATGAAGATTTTTTTGTTTCTGTAGATAGTAAACTCTTTTTTTAAAAAAGGAAAAGGGAAACATTTTTA
TAAAGTTATATTTTAATCACCATTTTTATACATTGTAGTTCTCTCCAAGCCCAGTAAGAGAATGATGATTCATTTGCATGGAGGTCGATG
GACAACCAATCATCTACCTTTTCTAATTTAAATGATAATCTGATATAGTTTTATTGCCAGTTAAATGAGGATGCTGCAAAGCATGTTTTT
TCACTAGTAACTTTTGCTAACTGAATGAATTCTGGGTCCATATCTCCCAGATGAAAAACTGTTAACCAATACCATATTTTATAGTTGGTG
TCCATTTCTTTCCAACACTGTTTGTTATGATTCTTCCTTGAGTACTTATATACAGACCTGCTCATTATCTAAACAATCTTACCTTCTAAG
TAAACCTTGATTGTGATTTCCAGTTTTTATTTTCTCTGACGTAGTAGAAAGGAATGTTTACATTAAAAATACTTTTGTTTCTCATAAATG
GATATTGTACTCCCCCCTTTCAAAGCATTATTTTACAATAATTCATGGCATTTTAAAAAATAAGGCAAAGATAATACGACAAAAAATATA
CATGGTTTCAAGGCAAATTCTCCAATAAGTTGGAAAATGTAAAAAGGATCAAGTGGATGCAGCCTCTACCTAAATAATTAAAATATATTT
CAGTATATTTCTGAATTAACACCAGGTCTTCATTATTTAGAACTTACTAAATTGTTTTCATTTTCTTAGTTTTACCTGTGTATCTCCATG
TTTGCAAAAATTACTATAAGTCAAATTTTGCCAGTGAATTTAACTATTTTTCTTTCCTTGCAATTAAGGGGAAAAAAGCATTTATCTTAT
CTTCTCATACCCCTTGCATCTAAGTACTTAGCAAAGTCAATATTTTCCCATTTTCCAAATGCGTCCATCTCTAACATAAATATTAATTGA
ACATAGAGCTATGTTTGGAGTGAGTGGACTGGCAGGACAGTTGGAAGTCCATCACAGTCTATTGACAGTTTCATCAAAGCTGTATAGTCC
AACTAGTGGGGCAGCTTGGCTACTATGGTGGAAGTCTCAGCAAACTGCCTGGTTTTGTTTGTTTGTTTTGTTTTAAGGTACAGGAAATAA
GAGGAATAATAGTGGCCAAAGCAATTAGAACATCTTCATTCCAGAACTGTGTTCAGCAATCCAGGCAGATTGATACATTTTTCTTTAAAA
ATAAATTGCTATTACAGCTAGACGTCAATTGGGATAAATAAAGGGATGAAGATCCACTAAGTTTGTGACTTTCATACACACCCAGTACAT
CTCAAAGGATGCTAAGGGACATTTTCTGCCAGTAGAGTTCTCCCCCTTTTTGGTGACAGCAATATTATTATGTTCACATCTAACTCCAGA
GCTTACTTCCTGTGGTGCCAATGTATTTGTTGCAATTTACTACATTTTTATATGAGCCTATTTATAGGTGCCATTAAACTCAGGTCTTTC
AAATGAAAGAGTTTCTAGCCCACTTAGGGAAAAAGATAATTGTTTAGAAAACCATAAAATCAATGGTAGGAAAAGTTGGAACTGGTTACC
TGGATGCCATGGTTCTCTGTTAAATAAAGTAAGAGACCAGGTGTATTCTGAGTGTCATCAGTGTTATTTTCAGCATGCTAATAAATGTCT
TTCCGGTTATATATCTATCTAAATTAACCTTTAAAATATTGGTTTCCTTGATAAAAGCACCACTTTTGCTTTTGTTAGCTGTAATATTTT
TTGTCATTTAGATAAGACCTGGTTTGGCTCTCAATAAAAGATGAAGACAGTAGCTCTGTACAGGGATATATCTATATTAGTCTTCATCTG
ATGAATGAAGAAATTTTCTCATATTATGTTCAAGAAAGTATTTACTTCCTAAAAATAGAATTCCCGATTCTGTCTATTTTGGTTGAATAC
CAGAACAAATCTTTCCGTTGCAATCCCAGTAAAACGAAAGAAAAGGAATATCTTACAGACTGTTCATATTAGATGTATGTAGACTGTTAA
TTTGCAATTTCCCCATATTTCCTGCCTATCTTACCCAGATAACTTTCTTTGAAGGTAAAAGCTGTGCAAAAGGCATGAGACTCAGGCCTA
CTCTTTGTTTAAATGATGGAAAAATATAAATTATTTTCTAAGTAATAAAAGTATAAAAATTATCATTATAAATAAAGTCTAAAGTTTGAA
ATTATTAATTTATAAAAGTGAACTAATTGTGTGATTATCAAATCCTGATTAATGAGAAGTGAATAATCTAAAAATCATTTATATTCTACT
GTGGGAGGTATTCTTGGTGCTTCCATGTCAGTATCGGGCTCTCCATTGTCCTCATCATTTATAGTACTTCTAAAATAATAATGGAAACCT
CAATAAGGGTCTTGTCCTCTTCTGTCATCCTAACCCTGATTCTAGTTTAATGCCTTTCCTGACTTATATGCCATTTGTAAATAAACTTCC

>50478_50478_3_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000439021_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=888AA_BP=67
MRHDAHKDVRSRRQMTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLMGHSEWDHKRGPRGSQSSGTSI
TVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGL
LRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLS
SPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPS
RTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENI
GRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSG
FTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEY
NFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY
EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKK

--------------------------------------------------------------
>50478_50478_4_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000567954_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=6826nt_BP=250nt
CACGGCTCTGCTGGGCTCCTGGCGCCGCCTCCTCCCAGCCCGCCGCGGGCTGCGCGCTTCTGTGGGTGGGGGAAGGCAGGACTGACGCAG
AATGACAACGGCAACACGACAAGAAGTCCTTGGCCTCTACCGCAGCATTTTCAGGCTTGCGAGGAAATGGCAGGCGACATCAGGGCAGAT
GGAAGACACCATCAAAGAAAAACAGTACATACTAAATGAAGCCAGAACGCTGTTCCGGAAAAACAAAAATCTCATGGGGCATTCAGAATG
GGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGAACCAGTATTACTGTGGACATCGCCGTCATGGGCGAGGCCCACGGCCTCAT
TACCGACCTCCTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTGCTCAGCACACAGCTCACCTT
CCAGGCCATTCACAAGCCCAGAGTGAATCCCGTCACTTCGCTCAGTGAAAACTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGA
CAAGCTTGCTATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACTTGGACCACCACCACCTCGGC
CACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGAGACCGCAGCACCAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGA
TTCTTGGAATAATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCTGCAGCTAACCATGTAAAGGC
TAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCACCTCTTTCATCGCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAG
CCTGGTCAGCAAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGTTCTCACAGGGCCTTAACTTA
CACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACTCCACCTGTTATATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCC
TGCTGATGAGCCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTAGAACAGATGACACTGCTCAAGTTACCTCTGATTATGAAAC
CAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAAGATGAAACAGAGTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAG
CACCTATGCTCCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGATAACCTGGACTCAATTATGGA
GCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTGGAAAATATAGGAAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAG
ACTTTTTGAAGACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCATGCTTTGGAGATTGGATATAG
GGATATTCCTTATCATAACAGAATCCATGCCACTGATGTTTTACATGCTGTTTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAAC
TGTGATTAATGATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGGACATATGGGATATGTATTCTCAAAAACGTA
TAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAATATCCCTGCCTTGGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGA
TTATGATCATCCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAACGATCGTTCAGTTTTGGAGAA
TCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGGCCAGAGTATAACTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTT
CCGTTTCCTTGTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTTAATGGCAAGGTAAATGATGA
TGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTGGTTTGTCAAATGTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATG
TAAAGAACTCCATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCCAGCCTTGGATTACCCATAAG
CCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTTCAGGAATCCTTCATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGA
TTCAGCAGGACTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAAGAAGAGGAGGAAGAAGCACC
AGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCTCCAAAAAAGAAGACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCA
GCACCTCTTACAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAAAATCAATCCCTGGACCAGAC
CCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAGGAAGAAGAAGAAGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCA
AAAGCCAGACCAGTGACAATGGATAGAATGGGCTGTGTTTCCAAACAGATTGACTTGTCAAAGACTCTCTTCAAGCCAGCACAACATTTA
GACACAACACTGTAGAAATTTGAGATGGGCAAATGGCTATTGCATTTTGGGATTCTTCGCATTTTGTGTGTATATTTTTACAGTGAGGTA
CATTGTTAAAAACTTTTTGCTCAAAGAAGCTTTCACATTGCAACACCAGCTTCTAAGGATTTTTTAAGGAGGGAATATATATGTGTGTGT
GTATATAAGCTCCCACATAGATACATGTAAAACATATTCACACCCATGCACGCACACACATACACACTGAAGGCCACGATTGCTGGCTCC
ACAATTTAGTAACATTTATATTAAGATATATATATAGTGGTCACTGTGATATAATAAATCATAAAGGAAACCAAATCACAAAGGAGATGG
TGTGGCTTAGCAAGGAAACAGTGCAGGAAATGTAGGTTACCAACTAAGCAGCTTTTGCTCTTAGTACTGAGGGATGAAAGTTCCAGAGCA
TTATTTGAATTCTGATACATCCTGCCAACACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAAGAGAGACAGAAG
GGAATGGTTTGAGAGGGTGCTTGTGTGCATGTGTGTGCATATGTAAAGAGATTTTTGTGGTTTAAGTAACTCAGAATAGCTGTAGCAAAT
GACTGAATACATGTGAACAAACAGAAGGAAGTTCACTCTGGAGTGTCTTTGGGAGGCAGCCATTCCAAATGCCCTCCTCCATTTAGCTTC
AATAAAGGGCCTTTTGCTGATGGAGGGCACTCAAGGGCTGGGTGAGAGGGCCACGTGTTTGGTATTACATTACTGCTATGCACCACTTGA
AGGAGCTCTATCACCAGCCTCAAACCCGAAAGACTGAGGCATTTTCCAGTCTACTTGCCTAATGAATGTATAGGAACTGTCTATGAGTAT
GGATGTCACTCAACTAAGATCAAATCACCATTTAAGGGGATGGCATTCTTTATACCTAAACACCTAAGAGCTGAAGTCAGGTCTTTTAAT
CAGGTTAGAATTCTAAATGATGCCAGAGAAGGCTTGGGAAATTGTACTTCAGCGTGATAGCCTGTGTCTTCTTAATTTGCTGCAAAATAT
GTGGTAGAGAAAGAAAAGGAAACAGAAAAATCACTCTGGGTTATATAGCAAGAGATGAAGGAGAATATTTCAACACAGGGTTTTTGTGTT
GACATAGGAAAAGCCTGATTCTTGGCAACTGTTGTAGTTTGTCTTTCAGGGGTGAAGGTCCCACTGACAACCCCTGTTGTGGTGTTCCAC
ACGCTGTTTGTTGGGGTAGCTTCCATCGGCAGTCTGGCCCATTGTCAGTCATGCTTCTTCTGGCCGGGGAGATTATAGAGAGATTGTTTG
AAGATTGGGTTATTATTGAAAGTCTTTTTTTTTGTTTGTTTTGTTTTGGTTTGTTTGTTTATCTACACTTGTTTATGCTGTGAGCCAAAC
CTCTATTTAAAAAGTTGATACTCACTTTCAATATTTTATTTCATATTATTATATATGTCATGATAGTTATCTTGATGTAAATATGAAGAT
TTTTTTGTTTCTGTAGATAGTAAACTCTTTTTTTAAAAAAGGAAAAGGGAAACATTTTTATAAAGTTATATTTTAATCACCATTTTTATA
CATTGTAGTTCTCTCCAAGCCCAGTAAGAGAATGATGATTCATTTGCATGGAGGTCGATGGACAACCAATCATCTACCTTTTCTAATTTA
AATGATAATCTGATATAGTTTTATTGCCAGTTAAATGAGGATGCTGCAAAGCATGTTTTTTCACTAGTAACTTTTGCTAACTGAATGAAT
TCTGGGTCCATATCTCCCAGATGAAAAACTGTTAACCAATACCATATTTTATAGTTGGTGTCCATTTCTTTCCAACACTGTTTGTTATGA
TTCTTCCTTGAGTACTTATATACAGACCTGCTCATTATCTAAACAATCTTACCTTCTAAGTAAACCTTGATTGTGATTTCCAGTTTTTAT
TTTCTCTGACGTAGTAGAAAGGAATGTTTACATTAAAAATACTTTTGTTTCTCATAAATGGATATTGTACTCCCCCCTTTCAAAGCATTA
TTTTACAATAATTCATGGCATTTTAAAAAATAAGGCAAAGATAATACGACAAAAAATATACATGGTTTCAAGGCAAATTCTCCAATAAGT
TGGAAAATGTAAAAAGGATCAAGTGGATGCAGCCTCTACCTAAATAATTAAAATATATTTCAGTATATTTCTGAATTAACACCAGGTCTT
CATTATTTAGAACTTACTAAATTGTTTTCATTTTCTTAGTTTTACCTGTGTATCTCCATGTTTGCAAAAATTACTATAAGTCAAATTTTG
CCAGTGAATTTAACTATTTTTCTTTCCTTGCAATTAAGGGGAAAAAAGCATTTATCTTATCTTCTCATACCCCTTGCATCTAAGTACTTA
GCAAAGTCAATATTTTCCCATTTTCCAAATGCGTCCATCTCTAACATAAATATTAATTGAACATAGAGCTATGTTTGGAGTGAGTGGACT
GGCAGGACAGTTGGAAGTCCATCACAGTCTATTGACAGTTTCATCAAAGCTGTATAGTCCAACTAGTGGGGCAGCTTGGCTACTATGGTG
GAAGTCTCAGCAAACTGCCTGGTTTTGTTTGTTTGTTTTGTTTTAAGGTACAGGAAATAAGAGGAATAATAGTGGCCAAAGCAATTAGAA
CATCTTCATTCCAGAACTGTGTTCAGCAATCCAGGCAGATTGATACATTTTTCTTTAAAAATAAATTGCTATTACAGCTAGACGTCAATT
GGGATAAATAAAGGGATGAAGATCCACTAAGTTTGTGACTTTCATACACACCCAGTACATCTCAAAGGATGCTAAGGGACATTTTCTGCC
AGTAGAGTTCTCCCCCTTTTTGGTGACAGCAATATTATTATGTTCACATCTAACTCCAGAGCTTACTTCCTGTGGTGCCAATGTATTTGT
TGCAATTTACTACATTTTTATATGAGCCTATTTATAGGTGCCATTAAACTCAGGTCTTTCAAATGAAAGAGTTTCTAGCCCACTTAGGGA
AAAAGATAATTGTTTAGAAAACCATAAAATCAATGGTAGGAAAAGTTGGAACTGGTTACCTGGATGCCATGGTTCTCTGTTAAATAAAGT
AAGAGACCAGGTGTATTCTGAGTGTCATCAGTGTTATTTTCAGCATGCTAATAAATGTCTTTCCGGTTATATATCTATCTAAATTAACCT
TTAAAATATTGGTTTCCTTGATAAAAGCACCACTTTTGCTTTTGTTAGCTGTAATATTTTTTGTCATTTAGATAAGACCTGGTTTGGCTC
TCAATAAAAGATGAAGACAGTAGCTCTGTACAGGGATATATCTATATTAGTCTTCATCTGATGAATGAAGAAATTTTCTCATATTATGTT
CAAGAAAGTATTTACTTCCTAAAAATAGAATTCCCGATTCTGTCTATTTTGGTTGAATACCAGAACAAATCTTTCCGTTGCAATCCCAGT
AAAACGAAAGAAAAGGAATATCTTACAGACTGTTCATATTAGATGTATGTAGACTGTTAATTTGCAATTTCCCCATATTTCCTGCCTATC
TTACCCAGATAACTTTCTTTGAAGGTAAAAGCTGTGCAAAAGGCATGAGACTCAGGCCTACTCTTTGTTTAAATGATGGAAAAATATAAA
TTATTTTCTAAGTAATAAAAGTATAAAAATTATCATTATAAATAAAGTCTAAAGTTTGAAATTATTAATTTATAAAAGTGAACTAATTGT
GTGATTATCAAATCCTGATTAATGAGAAGTGAATAATCTAAAAATCATTTATATTCTACTGTGGGAGGTATTCTTGGTGCTTCCATGTCA
GTATCGGGCTCTCCATTGTCCTCATCATTTATAGTACTTCTAAAATAATAATGGAAACCTCAATAAGGGTCTTGTCCTCTTCTGTCATCC

>50478_50478_4_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000567954_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=874AA_BP=53
MTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLI
TDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSA
TGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASS
LVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYET
NNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYR
LFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTY
NVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHF
RFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPIS
PFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQ

--------------------------------------------------------------
>50478_50478_5_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000568663_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=7076nt_BP=500nt
AGGACAGAGGACCAGAGTCTGCACCCCCTCCAGGGCAGCTCCAACCCCATATCCCCAGGCCCTGGGTTGAGGGGTGCTGGCGGTGGGGAG
GCAGGGACAGTAGGCTCCCTACCCCCGCCGCCGCCGCCTCTTCTTCCACCACTGCCACCGCCTCCTCTTCATCTGCGGCCCACCGGCGGC
GGCCGCCCCGAAGCCCCGCCCCCTCCATCGCCTCCTGCATCATCACTTCCGGTAACCCCGCCGGCCGCCAGCTCCAGGAGGGAGAATGGG
AGAGGGGCAAGGAGGGAACGAGTGGAAGATTGCGTCACGACGCACATAAAGACGTACGAAGCCGTCGCCAAATGACAACGGCAACACGAC
AAGAAGTCCTTGGCCTCTACCGCAGCATTTTCAGGCTTGCGAGGAAATGGCAGGCGACATCAGGGCAGATGGAAGACACCATCAAAGAAA
AACAGTACATACTAAATGAAGCCAGAACGCTGTTCCGGAAAAACAAAAATCTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAA
GAGGATCACAGTCTTCAGGAACCAGTATTACTGTGGACATCGCCGTCATGGGCGAGGCCCACGGCCTCATTACCGACCTCCTGGCAGACC
CTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTGCTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCA
GAGTGAATCCCGTCACTTCGCTCAGTGAAAACTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCTATTCCAAAGC
GCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACTTGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGG
AGCCTGCACCAGTACGGAGAGACCGCAGCACCAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAATAATCCAGTGA
TGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCTGCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAG
GTGCCCTCGCTAAAATTTCACCTCTTTCATCGCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGCAAAATTTCTG
CAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGTTCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACC
TATCCCCTCAAATCCTGACTCCACCTGTTATATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAGCCCCTGGAGA
GAAGTGGGGTAGCCACTCGGACACCAAGTAGAACAGATGACACTGCTCAAGTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCA
GTGACATTGTACAGAATGAAGATGAAACAGAGTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCTCCTGAGACCA
TGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGATAACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATT
TTCCAATTTTTGATTTAGTGGAAAATATAGGAAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAAGACATGGGCC
TCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCATGCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACA
GAATCCATGCCACTGATGTTTTACATGCTGTTTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAATGATCATGGTT
CAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGGACATATGGGATATGTATTCTCAAAAACGTATAATGTGACAGATGATAAAT
ACGGATGTCTGTCTGGGAATATCCCTGCCTTGGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCATCCAGGAAGGA
CTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAACGATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCAT
GGAATCTTTTCATGTCCCGGCCAGAGTATAACTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTTGTCATTGAAG
CAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTTAATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCA
ATGAAAATGATCGTCTACTGGTTTGTCAAATGTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTCCATCTTCAGT
GGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCCAGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTG
CTCCTCAGCTGGCCAACCTTCAGGAATCCTTCATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGACTAATGCCTG
GAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAAGAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAA
CCTGTGAAAATAATGAATCTCCAAAAAAGAAGACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTACAGAACCACA
AGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAAAATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAG
AACAGATCCAGGCTATCAAGGAAGAAGAAGAAGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGACCAGTGACAAT
GGATAGAATGGGCTGTGTTTCCAAACAGATTGACTTGTCAAAGACTCTCTTCAAGCCAGCACAACATTTAGACACAACACTGTAGAAATT
TGAGATGGGCAAATGGCTATTGCATTTTGGGATTCTTCGCATTTTGTGTGTATATTTTTACAGTGAGGTACATTGTTAAAAACTTTTTGC
TCAAAGAAGCTTTCACATTGCAACACCAGCTTCTAAGGATTTTTTAAGGAGGGAATATATATGTGTGTGTGTATATAAGCTCCCACATAG
ATACATGTAAAACATATTCACACCCATGCACGCACACACATACACACTGAAGGCCACGATTGCTGGCTCCACAATTTAGTAACATTTATA
TTAAGATATATATATAGTGGTCACTGTGATATAATAAATCATAAAGGAAACCAAATCACAAAGGAGATGGTGTGGCTTAGCAAGGAAACA
GTGCAGGAAATGTAGGTTACCAACTAAGCAGCTTTTGCTCTTAGTACTGAGGGATGAAAGTTCCAGAGCATTATTTGAATTCTGATACAT
CCTGCCAACACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAAGAGAGACAGAAGGGAATGGTTTGAGAGGGTGC
TTGTGTGCATGTGTGTGCATATGTAAAGAGATTTTTGTGGTTTAAGTAACTCAGAATAGCTGTAGCAAATGACTGAATACATGTGAACAA
ACAGAAGGAAGTTCACTCTGGAGTGTCTTTGGGAGGCAGCCATTCCAAATGCCCTCCTCCATTTAGCTTCAATAAAGGGCCTTTTGCTGA
TGGAGGGCACTCAAGGGCTGGGTGAGAGGGCCACGTGTTTGGTATTACATTACTGCTATGCACCACTTGAAGGAGCTCTATCACCAGCCT
CAAACCCGAAAGACTGAGGCATTTTCCAGTCTACTTGCCTAATGAATGTATAGGAACTGTCTATGAGTATGGATGTCACTCAACTAAGAT
CAAATCACCATTTAAGGGGATGGCATTCTTTATACCTAAACACCTAAGAGCTGAAGTCAGGTCTTTTAATCAGGTTAGAATTCTAAATGA
TGCCAGAGAAGGCTTGGGAAATTGTACTTCAGCGTGATAGCCTGTGTCTTCTTAATTTGCTGCAAAATATGTGGTAGAGAAAGAAAAGGA
AACAGAAAAATCACTCTGGGTTATATAGCAAGAGATGAAGGAGAATATTTCAACACAGGGTTTTTGTGTTGACATAGGAAAAGCCTGATT
CTTGGCAACTGTTGTAGTTTGTCTTTCAGGGGTGAAGGTCCCACTGACAACCCCTGTTGTGGTGTTCCACACGCTGTTTGTTGGGGTAGC
TTCCATCGGCAGTCTGGCCCATTGTCAGTCATGCTTCTTCTGGCCGGGGAGATTATAGAGAGATTGTTTGAAGATTGGGTTATTATTGAA
AGTCTTTTTTTTTGTTTGTTTTGTTTTGGTTTGTTTGTTTATCTACACTTGTTTATGCTGTGAGCCAAACCTCTATTTAAAAAGTTGATA
CTCACTTTCAATATTTTATTTCATATTATTATATATGTCATGATAGTTATCTTGATGTAAATATGAAGATTTTTTTGTTTCTGTAGATAG
TAAACTCTTTTTTTAAAAAAGGAAAAGGGAAACATTTTTATAAAGTTATATTTTAATCACCATTTTTATACATTGTAGTTCTCTCCAAGC
CCAGTAAGAGAATGATGATTCATTTGCATGGAGGTCGATGGACAACCAATCATCTACCTTTTCTAATTTAAATGATAATCTGATATAGTT
TTATTGCCAGTTAAATGAGGATGCTGCAAAGCATGTTTTTTCACTAGTAACTTTTGCTAACTGAATGAATTCTGGGTCCATATCTCCCAG
ATGAAAAACTGTTAACCAATACCATATTTTATAGTTGGTGTCCATTTCTTTCCAACACTGTTTGTTATGATTCTTCCTTGAGTACTTATA
TACAGACCTGCTCATTATCTAAACAATCTTACCTTCTAAGTAAACCTTGATTGTGATTTCCAGTTTTTATTTTCTCTGACGTAGTAGAAA
GGAATGTTTACATTAAAAATACTTTTGTTTCTCATAAATGGATATTGTACTCCCCCCTTTCAAAGCATTATTTTACAATAATTCATGGCA
TTTTAAAAAATAAGGCAAAGATAATACGACAAAAAATATACATGGTTTCAAGGCAAATTCTCCAATAAGTTGGAAAATGTAAAAAGGATC
AAGTGGATGCAGCCTCTACCTAAATAATTAAAATATATTTCAGTATATTTCTGAATTAACACCAGGTCTTCATTATTTAGAACTTACTAA
ATTGTTTTCATTTTCTTAGTTTTACCTGTGTATCTCCATGTTTGCAAAAATTACTATAAGTCAAATTTTGCCAGTGAATTTAACTATTTT
TCTTTCCTTGCAATTAAGGGGAAAAAAGCATTTATCTTATCTTCTCATACCCCTTGCATCTAAGTACTTAGCAAAGTCAATATTTTCCCA
TTTTCCAAATGCGTCCATCTCTAACATAAATATTAATTGAACATAGAGCTATGTTTGGAGTGAGTGGACTGGCAGGACAGTTGGAAGTCC
ATCACAGTCTATTGACAGTTTCATCAAAGCTGTATAGTCCAACTAGTGGGGCAGCTTGGCTACTATGGTGGAAGTCTCAGCAAACTGCCT
GGTTTTGTTTGTTTGTTTTGTTTTAAGGTACAGGAAATAAGAGGAATAATAGTGGCCAAAGCAATTAGAACATCTTCATTCCAGAACTGT
GTTCAGCAATCCAGGCAGATTGATACATTTTTCTTTAAAAATAAATTGCTATTACAGCTAGACGTCAATTGGGATAAATAAAGGGATGAA
GATCCACTAAGTTTGTGACTTTCATACACACCCAGTACATCTCAAAGGATGCTAAGGGACATTTTCTGCCAGTAGAGTTCTCCCCCTTTT
TGGTGACAGCAATATTATTATGTTCACATCTAACTCCAGAGCTTACTTCCTGTGGTGCCAATGTATTTGTTGCAATTTACTACATTTTTA
TATGAGCCTATTTATAGGTGCCATTAAACTCAGGTCTTTCAAATGAAAGAGTTTCTAGCCCACTTAGGGAAAAAGATAATTGTTTAGAAA
ACCATAAAATCAATGGTAGGAAAAGTTGGAACTGGTTACCTGGATGCCATGGTTCTCTGTTAAATAAAGTAAGAGACCAGGTGTATTCTG
AGTGTCATCAGTGTTATTTTCAGCATGCTAATAAATGTCTTTCCGGTTATATATCTATCTAAATTAACCTTTAAAATATTGGTTTCCTTG
ATAAAAGCACCACTTTTGCTTTTGTTAGCTGTAATATTTTTTGTCATTTAGATAAGACCTGGTTTGGCTCTCAATAAAAGATGAAGACAG
TAGCTCTGTACAGGGATATATCTATATTAGTCTTCATCTGATGAATGAAGAAATTTTCTCATATTATGTTCAAGAAAGTATTTACTTCCT
AAAAATAGAATTCCCGATTCTGTCTATTTTGGTTGAATACCAGAACAAATCTTTCCGTTGCAATCCCAGTAAAACGAAAGAAAAGGAATA
TCTTACAGACTGTTCATATTAGATGTATGTAGACTGTTAATTTGCAATTTCCCCATATTTCCTGCCTATCTTACCCAGATAACTTTCTTT
GAAGGTAAAAGCTGTGCAAAAGGCATGAGACTCAGGCCTACTCTTTGTTTAAATGATGGAAAAATATAAATTATTTTCTAAGTAATAAAA
GTATAAAAATTATCATTATAAATAAAGTCTAAAGTTTGAAATTATTAATTTATAAAAGTGAACTAATTGTGTGATTATCAAATCCTGATT
AATGAGAAGTGAATAATCTAAAAATCATTTATATTCTACTGTGGGAGGTATTCTTGGTGCTTCCATGTCAGTATCGGGCTCTCCATTGTC
CTCATCATTTATAGTACTTCTAAAATAATAATGGAAACCTCAATAAGGGTCTTGTCCTCTTCTGTCATCCTAACCCTGATTCTAGTTTAA

>50478_50478_5_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000568663_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=888AA_BP=67
MRHDAHKDVRSRRQMTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLMGHSEWDHKRGPRGSQSSGTSI
TVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGL
LRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLS
SPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPS
RTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENI
GRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSG
FTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEY
NFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFY
EQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKK

--------------------------------------------------------------
>50478_50478_6_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000569023_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=7135nt_BP=559nt
AGGAGGGAGAATGGGAGAGGGGCAAGGAGGGAACGAGTGGAAGATTGCGTCACGACGCACATAAAGACGTACGAAGCCGTCGCCAAAGAG
TACCCAGAGAAGGAGAAGCCAGCAAAGGAGACGACACAGACAAGACCTCAGAGATCAAAGGAAGAGGCCCCTTAATATCCTGGAATAATG
GGACCCATCCCCGTAATCAGTGAATCTCATCCACCCGCTTGCCAGCTTCTACCCGCAGCAAGTAGAAGCTAAGTCCTGGCTCAAATCTCT
TCCCTCCCTCCCTCTCCCAGCTGTCAGTGCTTTTGGACTTGTGCTCAGGTGAAGTAGTATTTGAAGCTTTTCATCAGTTGGCTCATTCTT
TACTCAAGAATAAACCTCAAGAAACGTCATCAGGGTCAGAATGACAACGGCAACACGACAAGAAGTCCTTGGCCTCTACCGCAGCATTTT
CAGGCTTGCGAGGAAATGGCAGGCGACATCAGGGCAGATGGAAGACACCATCAAAGAAAAACAGTACATACTAAATGAAGCCAGAACGCT
GTTCCGGAAAAACAAAAATCTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGAACCAGTATTAC
TGTGGACATCGCCGTCATGGGCGAGGCCCACGGCCTCATTACCGACCTCCTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTT
GAGAGCCGTGAGCAACTTGCTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTCACTTCGCTCAGTGAAAA
CTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCTATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTT
GAGACGAGTTTCTTCCACTTGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGAGACCGCAGCAC
CAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAATAATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTAC
TTCATCCTATGCTATTTCTGCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCACCTCTTTCATC
GCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGCAAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAAC
TGCCAAACAAAGCCTAGGTTCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACTCCACCTGTTAT
ATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAGCCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTAG
AACAGATGACACTGCTCAAGTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAAGATGAAACAGA
GTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCTCCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCC
CGAACCTCTTGTCATGGATAACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTGGAAAATATAGG
AAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAAGACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGA
ATTTATGAATTATTTTCATGCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTTTTACATGCTGT
TTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAATGATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATT
TACACATGGACATATGGGATATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAATATCCCTGCCTT
GGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCATCCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCC
TCAGGCGGTGCTATATAACGATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGGCCAGAGTATAA
CTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTTGTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTT
TGACTTCGTAGCCAAATTTAATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTGGTTTGTCAAAT
GTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTCCATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGA
ACAGGGTGATGAAGAGGCCAGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTTCAGGAATCCTT
CATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGACTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGG
AGATACTGATGACCCAGAAGAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCTCCAAAAAAGAA
GACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTACAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCA
ACGGTTGGCAGGCATAGAAAATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAGGAAGAAGAAGA
AGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGACCAGTGACAATGGATAGAATGGGCTGTGTTTCCAAACAGATT
GACTTGTCAAAGACTCTCTTCAAGCCAGCACAACATTTAGACACAACACTGTAGAAATTTGAGATGGGCAAATGGCTATTGCATTTTGGG
ATTCTTCGCATTTTGTGTGTATATTTTTACAGTGAGGTACATTGTTAAAAACTTTTTGCTCAAAGAAGCTTTCACATTGCAACACCAGCT
TCTAAGGATTTTTTAAGGAGGGAATATATATGTGTGTGTGTATATAAGCTCCCACATAGATACATGTAAAACATATTCACACCCATGCAC
GCACACACATACACACTGAAGGCCACGATTGCTGGCTCCACAATTTAGTAACATTTATATTAAGATATATATATAGTGGTCACTGTGATA
TAATAAATCATAAAGGAAACCAAATCACAAAGGAGATGGTGTGGCTTAGCAAGGAAACAGTGCAGGAAATGTAGGTTACCAACTAAGCAG
CTTTTGCTCTTAGTACTGAGGGATGAAAGTTCCAGAGCATTATTTGAATTCTGATACATCCTGCCAACACTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTGTGAAAGAGAGACAGAAGGGAATGGTTTGAGAGGGTGCTTGTGTGCATGTGTGTGCATATGTAAAGAGA
TTTTTGTGGTTTAAGTAACTCAGAATAGCTGTAGCAAATGACTGAATACATGTGAACAAACAGAAGGAAGTTCACTCTGGAGTGTCTTTG
GGAGGCAGCCATTCCAAATGCCCTCCTCCATTTAGCTTCAATAAAGGGCCTTTTGCTGATGGAGGGCACTCAAGGGCTGGGTGAGAGGGC
CACGTGTTTGGTATTACATTACTGCTATGCACCACTTGAAGGAGCTCTATCACCAGCCTCAAACCCGAAAGACTGAGGCATTTTCCAGTC
TACTTGCCTAATGAATGTATAGGAACTGTCTATGAGTATGGATGTCACTCAACTAAGATCAAATCACCATTTAAGGGGATGGCATTCTTT
ATACCTAAACACCTAAGAGCTGAAGTCAGGTCTTTTAATCAGGTTAGAATTCTAAATGATGCCAGAGAAGGCTTGGGAAATTGTACTTCA
GCGTGATAGCCTGTGTCTTCTTAATTTGCTGCAAAATATGTGGTAGAGAAAGAAAAGGAAACAGAAAAATCACTCTGGGTTATATAGCAA
GAGATGAAGGAGAATATTTCAACACAGGGTTTTTGTGTTGACATAGGAAAAGCCTGATTCTTGGCAACTGTTGTAGTTTGTCTTTCAGGG
GTGAAGGTCCCACTGACAACCCCTGTTGTGGTGTTCCACACGCTGTTTGTTGGGGTAGCTTCCATCGGCAGTCTGGCCCATTGTCAGTCA
TGCTTCTTCTGGCCGGGGAGATTATAGAGAGATTGTTTGAAGATTGGGTTATTATTGAAAGTCTTTTTTTTTGTTTGTTTTGTTTTGGTT
TGTTTGTTTATCTACACTTGTTTATGCTGTGAGCCAAACCTCTATTTAAAAAGTTGATACTCACTTTCAATATTTTATTTCATATTATTA
TATATGTCATGATAGTTATCTTGATGTAAATATGAAGATTTTTTTGTTTCTGTAGATAGTAAACTCTTTTTTTAAAAAAGGAAAAGGGAA
ACATTTTTATAAAGTTATATTTTAATCACCATTTTTATACATTGTAGTTCTCTCCAAGCCCAGTAAGAGAATGATGATTCATTTGCATGG
AGGTCGATGGACAACCAATCATCTACCTTTTCTAATTTAAATGATAATCTGATATAGTTTTATTGCCAGTTAAATGAGGATGCTGCAAAG
CATGTTTTTTCACTAGTAACTTTTGCTAACTGAATGAATTCTGGGTCCATATCTCCCAGATGAAAAACTGTTAACCAATACCATATTTTA
TAGTTGGTGTCCATTTCTTTCCAACACTGTTTGTTATGATTCTTCCTTGAGTACTTATATACAGACCTGCTCATTATCTAAACAATCTTA
CCTTCTAAGTAAACCTTGATTGTGATTTCCAGTTTTTATTTTCTCTGACGTAGTAGAAAGGAATGTTTACATTAAAAATACTTTTGTTTC
TCATAAATGGATATTGTACTCCCCCCTTTCAAAGCATTATTTTACAATAATTCATGGCATTTTAAAAAATAAGGCAAAGATAATACGACA
AAAAATATACATGGTTTCAAGGCAAATTCTCCAATAAGTTGGAAAATGTAAAAAGGATCAAGTGGATGCAGCCTCTACCTAAATAATTAA
AATATATTTCAGTATATTTCTGAATTAACACCAGGTCTTCATTATTTAGAACTTACTAAATTGTTTTCATTTTCTTAGTTTTACCTGTGT
ATCTCCATGTTTGCAAAAATTACTATAAGTCAAATTTTGCCAGTGAATTTAACTATTTTTCTTTCCTTGCAATTAAGGGGAAAAAAGCAT
TTATCTTATCTTCTCATACCCCTTGCATCTAAGTACTTAGCAAAGTCAATATTTTCCCATTTTCCAAATGCGTCCATCTCTAACATAAAT
ATTAATTGAACATAGAGCTATGTTTGGAGTGAGTGGACTGGCAGGACAGTTGGAAGTCCATCACAGTCTATTGACAGTTTCATCAAAGCT
GTATAGTCCAACTAGTGGGGCAGCTTGGCTACTATGGTGGAAGTCTCAGCAAACTGCCTGGTTTTGTTTGTTTGTTTTGTTTTAAGGTAC
AGGAAATAAGAGGAATAATAGTGGCCAAAGCAATTAGAACATCTTCATTCCAGAACTGTGTTCAGCAATCCAGGCAGATTGATACATTTT
TCTTTAAAAATAAATTGCTATTACAGCTAGACGTCAATTGGGATAAATAAAGGGATGAAGATCCACTAAGTTTGTGACTTTCATACACAC
CCAGTACATCTCAAAGGATGCTAAGGGACATTTTCTGCCAGTAGAGTTCTCCCCCTTTTTGGTGACAGCAATATTATTATGTTCACATCT
AACTCCAGAGCTTACTTCCTGTGGTGCCAATGTATTTGTTGCAATTTACTACATTTTTATATGAGCCTATTTATAGGTGCCATTAAACTC
AGGTCTTTCAAATGAAAGAGTTTCTAGCCCACTTAGGGAAAAAGATAATTGTTTAGAAAACCATAAAATCAATGGTAGGAAAAGTTGGAA
CTGGTTACCTGGATGCCATGGTTCTCTGTTAAATAAAGTAAGAGACCAGGTGTATTCTGAGTGTCATCAGTGTTATTTTCAGCATGCTAA
TAAATGTCTTTCCGGTTATATATCTATCTAAATTAACCTTTAAAATATTGGTTTCCTTGATAAAAGCACCACTTTTGCTTTTGTTAGCTG
TAATATTTTTTGTCATTTAGATAAGACCTGGTTTGGCTCTCAATAAAAGATGAAGACAGTAGCTCTGTACAGGGATATATCTATATTAGT
CTTCATCTGATGAATGAAGAAATTTTCTCATATTATGTTCAAGAAAGTATTTACTTCCTAAAAATAGAATTCCCGATTCTGTCTATTTTG
GTTGAATACCAGAACAAATCTTTCCGTTGCAATCCCAGTAAAACGAAAGAAAAGGAATATCTTACAGACTGTTCATATTAGATGTATGTA
GACTGTTAATTTGCAATTTCCCCATATTTCCTGCCTATCTTACCCAGATAACTTTCTTTGAAGGTAAAAGCTGTGCAAAAGGCATGAGAC
TCAGGCCTACTCTTTGTTTAAATGATGGAAAAATATAAATTATTTTCTAAGTAATAAAAGTATAAAAATTATCATTATAAATAAAGTCTA
AAGTTTGAAATTATTAATTTATAAAAGTGAACTAATTGTGTGATTATCAAATCCTGATTAATGAGAAGTGAATAATCTAAAAATCATTTA
TATTCTACTGTGGGAGGTATTCTTGGTGCTTCCATGTCAGTATCGGGCTCTCCATTGTCCTCATCATTTATAGTACTTCTAAAATAATAA
TGGAAACCTCAATAAGGGTCTTGTCCTCTTCTGTCATCCTAACCCTGATTCTAGTTTAATGCCTTTCCTGACTTATATGCCATTTGTAAA

>50478_50478_6_LYRM1-PDE3A_LYRM1_chr16_20927036_ENST00000569023_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=874AA_BP=53
MTTATRQEVLGLYRSIFRLARKWQATSGQMEDTIKEKQYILNEARTLFRKNKNLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLI
TDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSA
TGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASS
LVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYET
NNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYR
LFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTY
NVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHF
RFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPIS
PFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQ

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Fusion Gene PPI Analysis for LYRM1-PDE3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LYRM1-PDE3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LYRM1-PDE3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource