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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LYRM7-SLC6A7 (FusionGDB2 ID:50494)

Fusion Gene Summary for LYRM7-SLC6A7

check button Fusion gene summary
Fusion gene informationFusion gene name: LYRM7-SLC6A7
Fusion gene ID: 50494
HgeneTgene
Gene symbol

LYRM7

SLC6A7

Gene ID

90624

6534

Gene nameLYR motif containing 7solute carrier family 6 member 7
SynonymsC5orf31|MC3DN8|MZM1LPROT
Cytomap

5q23.3-q31.1

5q32

Type of geneprotein-codingprotein-coding
Descriptioncomplex III assembly factor LYRM7LYR motif-containing protein 7Lyrm7 homologsodium-dependent proline transporterbrain-specific L-proline transportersolute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Modification date2020031320200313
UniProtAcc

Q5U5X0

.
Ensembl transtripts involved in fusion geneENST00000379380, ENST00000507584, 
ENST00000510516, ENST00000521227, 
ENST00000230671, ENST00000524041, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: LYRM7 [Title/Abstract] AND SLC6A7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLYRM7(130506731)-SLC6A7(149574291), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLYRM7

GO:0034551

mitochondrial respiratory chain complex III assembly

23168492

HgeneLYRM7

GO:0045333

cellular respiration

23168492


check buttonFusion gene breakpoints across LYRM7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC6A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-X6-A8C2-01ALYRM7chr5

130506731

+SLC6A7chr5

149574291

+


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Fusion Gene ORF analysis for LYRM7-SLC6A7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000379380ENST00000230671LYRM7chr5

130506731

+SLC6A7chr5

149574291

+
In-frameENST00000379380ENST00000524041LYRM7chr5

130506731

+SLC6A7chr5

149574291

+
In-frameENST00000507584ENST00000230671LYRM7chr5

130506731

+SLC6A7chr5

149574291

+
In-frameENST00000507584ENST00000524041LYRM7chr5

130506731

+SLC6A7chr5

149574291

+
In-frameENST00000510516ENST00000230671LYRM7chr5

130506731

+SLC6A7chr5

149574291

+
In-frameENST00000510516ENST00000524041LYRM7chr5

130506731

+SLC6A7chr5

149574291

+
intron-3CDSENST00000521227ENST00000230671LYRM7chr5

130506731

+SLC6A7chr5

149574291

+
intron-3CDSENST00000521227ENST00000524041LYRM7chr5

130506731

+SLC6A7chr5

149574291

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379380LYRM7chr5130506731+ENST00000230671SLC6A7chr5149574291+35642291482106652
ENST00000379380LYRM7chr5130506731+ENST00000524041SLC6A7chr5149574291+23842291482196682
ENST00000510516LYRM7chr5130506731+ENST00000230671SLC6A7chr5149574291+343095141972652
ENST00000510516LYRM7chr5130506731+ENST00000524041SLC6A7chr5149574291+225095142062682
ENST00000507584LYRM7chr5130506731+ENST00000230671SLC6A7chr5149574291+33855021927641
ENST00000507584LYRM7chr5130506731+ENST00000524041SLC6A7chr5149574291+22055022017671

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379380ENST00000230671LYRM7chr5130506731+SLC6A7chr5149574291+0.0049948660.9950052
ENST00000379380ENST00000524041LYRM7chr5130506731+SLC6A7chr5149574291+0.009179410.9908206
ENST00000510516ENST00000230671LYRM7chr5130506731+SLC6A7chr5149574291+0.0052713430.9947286
ENST00000510516ENST00000524041LYRM7chr5130506731+SLC6A7chr5149574291+0.0105645110.98943543
ENST00000507584ENST00000230671LYRM7chr5130506731+SLC6A7chr5149574291+0.0052465290.9947535
ENST00000507584ENST00000524041LYRM7chr5130506731+SLC6A7chr5149574291+0.0103087670.9896912

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Fusion Genomic Features for LYRM7-SLC6A7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
LYRM7chr5130506731+SLC6A7chr5149574290+1.22E-060.9999988
LYRM7chr5130506731+SLC6A7chr5149574290+1.22E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for LYRM7-SLC6A7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:130506731/chr5:149574291)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYRM7

Q5U5X0

.
FUNCTION: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. {ECO:0000269|PubMed:23168492}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014138_21411637.0Topological domainExtracellular
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014557_63611637.0Topological domainCytoplasmic
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014117_13711637.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014215_23311637.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014242_25911637.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014295_31211637.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014324_34511637.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014378_39711637.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014425_44311637.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014459_47911637.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A7chr5:130506731chr5:149574291ENST0000023067101446_6611637.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014500_51911637.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A7chr5:130506731chr5:149574291ENST00000230671014538_55611637.0TransmembraneHelical%3B Name%3D12
TgeneSLC6A7chr5:130506731chr5:149574291ENST0000023067101474_9311637.0TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC6A7chr5:130506731chr5:149574291ENST000002306710141_4511637.0Topological domainCytoplasmic


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Fusion Gene Sequence for LYRM7-SLC6A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50494_50494_1_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000379380_SLC6A7_chr5_149574291_ENST00000230671_length(transcript)=3564nt_BP=229nt
AGCAAACGCCTTTAGCAAACGCCCGTTTAGCAAACGCCTCCTCCGTCCTTTGGAGGAGGGCGGGGCTAAAAGGGAGATGCTGCCTAGTGA
TTCGTTGTGGCGCATTAGTAACGCGACTACAGGGGGCTGGAAACAGTTCAGTCTTTGATTGGTTGCTGAGAGGCGGGGCTACTCGACTGC
TCTGGAGGTAGCGGCCGCGGTGAGGAGAGCCATGGGACGGGCAGTCAAGCCTGTCACCCCAGACCTGCTGATGACCCCCAGTGACCAGGG
CGATGTCGACCTGGATGTGGACTTTGCTGCACACCGGGGGAACTGGACAGGCAAGCTGGACTTCCTGCTGTCCTGCATTGGCTACTGTGT
AGGCCTGGGGAATGTCTGGCGCTTCCCCTATCGAGCGTACACCAATGGAGGAGGCGCCTTCCTCGTGCCCTACTTCCTCATGCTGGCCAT
CTGTGGCATCCCCCTCTTCTTCCTGGAGCTCTCCCTGGGCCAGTTCTCCAGCCTAGGGCCCCTGGCTGTCTGGAAAATCAGCCCTCTCTT
CAAAGGCGCCGGCGCAGCCATGCTGCTCATCGTGGGCTTGGTGGCCATCTACTACAACATGATCATCGCCTACGTGCTCTTCTACCTCTT
CGCCTCCCTCACCAGCGACCTACCCTGGGAGCACTGTGGCAACTGGTGGAACACAGAACTCTGCCTGGAGCACAGAGTCTCCAAGGACGG
CAACGGGGCCCTGCCCCTCAACCTCACCTGCACCGTCAGCCCCAGCGAGGAGTACTGGAGCCGCTACGTCCTCCACATCCAAGGCAGCCA
GGGCATCGGCAGCCCTGGGGAGATCCGCTGGAACCTCTGCCTCTGCCTGCTGCTGGCCTGGGTCATCGTGTTCCTCTGTATCCTCAAGGG
TGTGAAGTCTTCGGGCAAGGTGGTGTATTTCACGGCCACGTTCCCCTACCTCATCCTGCTCATGCTGCTGGTCCGCGGAGTCACCCTCCC
AGGGGCCTGGAAGGGCATCCAGTTCTATCTCACCCCCCAGTTCCACCACTTGTTGTCTTCCAAGGTGTGGATTGAAGCTGCTCTTCAGAT
CTTCTATTCCCTGGGTGTGGGCTTCGGGGGGCTCCTCACCTTTGCCTCCTACAACACGTTTCACCAGAACATCTATAGAGACACTTTCAT
CGTCACTCTGGGCAACGCCATCACCAGCATCCTGGCTGGCTTTGCCATCTTCTCCGTGCTGGGCTACATGTCTCAGGAGCTGGGCGTGCC
TGTGGACCAAGTAGCCAAAGCAGGCCCTGGCCTGGCCTTTGTCGTCTACCCACAGGCCATGACCATGCTGCCTCTGTCACCCTTCTGGTC
CTTTCTCTTCTTCTTCATGCTTCTGACTCTCGGCCTAGATAGCCAGTTTGCTTTTCTGGAGACCATTGTGACAGCTGTGACAGATGAGTT
CCCATACTACCTGCGGCCCAAGAAGGCGGTGTTCTCAGGGCTCATCTGCGTGGCCATGTACCTGATGGGGCTGATCCTCACCACTGATGG
GGGCATGTACTGGCTGGTCCTTCTGGATGACTACAGCGCCAGCTTCGGGCTGATGGTGGTGGTTATCACCACGTGCCTTGCCGTGACACG
GGTGTATGGCATTCAGAGGTTCTGCCGAGACATCCACATGATGCTGGGCTTCAAGCCGGGCCTCTACTTCAGGGCCTGCTGGCTGTTCCT
GTCCCCAGCCACGCTCTTGGCCCTCATGGTGTATAGCATCGTCAAGTACCAGCCCTCGGAGTATGGCAGTTACCGCTTCCCGCCCTGGGC
TGAGCTGCTGGGCATCCTGATGGGCCTGCTGTCCTGCCTCATGATCCCAGCTGGCATGCTGGTGGCTGTGCTTCGAGAAGAGGGCTCACT
CTGGGAGCGGCTCCAACAGGCCAGCCGGCCGGCCATGGACTGGGGACCATCGCTGGAGGAGAACCGGACGGGCATGTATGTGGCCACGCT
GGCTGGGAGCCAGTCACCAAAGCCACTGATGGTGCACATGCGCAAGTACGGGGGCATCACCAGCTTCGAGAACACGGCCATCGAGGTGGA
CCGTGAGATTGCAGAGGAGGAGGAGTCGATGATGTGAGGCAGGAGGCAGGCGGGCAGAAGGCCCTGCCCGGGACCTCACAGTCCCTTCTT
AGAAGCCTGCAAAGGTCAGCTGTGCCCTCTGGGATTCTGAGAGGCTATGGGGGGGCCTGCCATAGGGATGCCAGTCCCCCAGTGGGGGTC
CCTTCTGCAGCCTCTGCCTCTCCTGAAACCTCTGACAACCCCCTACACACACACACAGGCATACTCAGACCCACTCAAAGCTGAGAATGA
TCCAACTCAGCCCTACTTTGCGGATGGACATATTAAGGCCAGGAGGGGAGGGACTTGCCCCAGGTCGCATGGCAGAGGGGACTTGAACCC
ACGCCTCCTGACCAGCCAGCTCCCTTTCCCATGGGGCAGCCGGCACCACCTTCTCATCTCTATTCAGGGCCTACACCCCTCCCTTTTTGG
GGGGAGCCTGTCCCCACACACCTTAGCACAACCAGAATCTTGAGTTGGGCAGGGAAGGTCAGGGCTACAGAGGCTCTTGAGGCTCCGAGG
CCCTGGGGATCAAAGGTCAATGAGTTAGGTGGGGAGAAAGATCCCTGGGGGCTCCTGTATGCAGGACTCCTGAAGGAGGTGGGAGCTGAG
GGCCCTGGAGGATGGGGAAGGTTTGCAGAGAGAGGAAGAAGAGGGCAGGGTGGGGAGGAGCTCTGGGCCAGAGGATGCTGAGCTGCCTGG
GCAGAGACCAAGAGGGTTGGAGACACTAGTTTTACCAGGTTACAGGAGGGTTCAAGACAGAAGGAAAACTAACAGAGGGGGAGCCAGGGA
TGATGGGGTGGGCAGGGGATTTGCATGATGAGGAGTATCATTCCAGATCTGTGCAGAGCGGATCGGACGGGACAGGGTGGAGCGGGGAGG
CCTGTGCAAAGTGGGAAAGAGCTGCCGGTGGCCTGAGCCAGGGTGCTGGGGCTGCGGGTGGGGAAAGGAGGCCCCAGCACTTCAGACAAA
GACCACCCCTTCACCCACTGGACCCCAAGCCGCAAAAGCTGGGGAGGTAGGAAGGGTCACTGTGAGGGCCCAGGGCCCCTCTCTTCCCAT
CTCCCTTGTCCTGGTGGCCTTCAGTGTCTCTTCCAGTTCCAGGAGCTGCTGGGAAGCTGGCCTTCATTGTTGGTGACAGGGCAACCATGG
GACTAGGAGGTGGCCCATACACATGGCTGGCTGGTCCTGAGGCCACCCACCTTGTTCCAGGACATGGGCCCGGGCCCGGTGTGGGGGTAG
ACGCAGAGGGCAGAGGGTAGCCCTTGGTACTGTGGGTCCCTCAAAGAGGAGAGTGGGGTGCAGAAATGCCTCAGCATGGCTCATGCACAC
AGCATTCTCCCGTGGGGCAGGGTTCCCTCATGCAACAGGCCTCCCTGTGGCCAGCCTCTCTGCCTGTCTCTCGCTGCGTCCCCCCAACCC

>50494_50494_1_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000379380_SLC6A7_chr5_149574291_ENST00000230671_length(amino acids)=652AA_BP=27
MVAERRGYSTALEVAAAVRRAMGRAVKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGA
FLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTE
LCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL
LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSV
LGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM
YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPS
EYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGI

--------------------------------------------------------------
>50494_50494_2_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000379380_SLC6A7_chr5_149574291_ENST00000524041_length(transcript)=2384nt_BP=229nt
AGCAAACGCCTTTAGCAAACGCCCGTTTAGCAAACGCCTCCTCCGTCCTTTGGAGGAGGGCGGGGCTAAAAGGGAGATGCTGCCTAGTGA
TTCGTTGTGGCGCATTAGTAACGCGACTACAGGGGGCTGGAAACAGTTCAGTCTTTGATTGGTTGCTGAGAGGCGGGGCTACTCGACTGC
TCTGGAGGTAGCGGCCGCGGTGAGGAGAGCCATGGGACGGGCAGTCAAGCCTGTCACCCCAGACCTGCTGATGACCCCCAGTGACCAGGG
CGATGTCGACCTGGATGTGGACTTTGCTGCACACCGGGGGAACTGGACAGGCAAGCTGGACTTCCTGCTGTCCTGCATTGGCTACTGTGT
AGGCCTGGGGAATGTCTGGCGCTTCCCCTATCGAGCGTACACCAATGGAGGAGGCGCCTTCCTCGTGCCCTACTTCCTCATGCTGGCCAT
CTGTGGCATCCCCCTCTTCTTCCTGGAGCTCTCCCTGGGCCAGTTCTCCAGCCTAGGGCCCCTGGCTGTCTGGAAAATCAGCCCTCTCTT
CAAAGGCGCCGGCGCAGCCATGCTGCTCATCGTGGGCTTGGTGGCCATCTACTACAACATGATCATCGCCTACGTGCTCTTCTACCTCTT
CGCCTCCCTCACCAGCGACCTACCCTGGGAGCACTGTGGCAACTGGTGGAACACAGAACTCTGCCTGGAGCACAGAGTCTCCAAGGACGG
CAACGGGGCCCTGCCCCTCAACCTCACCTGCACCGTCAGCCCCAGCGAGGAGTACTGGAGCCGCTACGTCCTCCACATCCAAGGCAGCCA
GGGCATCGGCAGCCCTGGGGAGATCCGCTGGAACCTCTGCCTCTGCCTGCTGCTGGCCTGGGTCATCGTGTTCCTCTGTATCCTCAAGGG
TGTGAAGTCTTCGGGCAAGGTGGTGTATTTCACGGCCACGTTCCCCTACCTCATCCTGCTCATGCTGCTGGTCCGCGGAGTCACCCTCCC
AGGGGCCTGGAAGGGCATCCAGTTCTATCTCACCCCCCAGTTCCACCACTTGTTGTCTTCCAAGGTGTGGATTGAAGCTGCTCTTCAGAT
CTTCTATTCCCTGGGTGTGGGCTTCGGGGGGCTCCTCACCTTTGCCTCCTACAACACGTTTCACCAGAACATCTATAGAGACACTTTCAT
CGTCACTCTGGGCAACGCCATCACCAGCATCCTGGCTGGCTTTGCCATCTTCTCCGTGCTGGGCTACATGTCTCAGGAGCTGGGCGTGCC
TGTGGACCAAGTAGCCAAAGCAGGCCCTGGCCTGGCCTTTGTCGTCTACCCACAGGCCATGACCATGCTGCCTCTGTCACCCTTCTGGTC
CTTTCTCTTCTTCTTCATGCTTCTGACTCTCGGCCTAGATAGCCAGTTTGCTTTTCTGGAGACCATTGTGACAGCTGTGACAGATGAGTT
CCCATACTACCTGCGGCCCAAGAAGGCGGTGTTCTCAGGGCTCATCTGCGTGGCCATGTACCTGATGGGGCTGATCCTCACCACTGATGG
GGGCATGTACTGGCTGGTCCTTCTGGATGACTACAGCGCCAGCTTCGGGCTGATGGTGGTGGTTATCACCACGTGCCTTGCCGTGACACG
GGTGTATGGCATTCAGAGGTTCTGCCGAGACATCCACATGATGCTGGGCTTCAAGCCGGGCCTCTACTTCAGGGCCTGCTGGCTGTTCCT
GTCCCCAGCCACGCTCTTGGCCCTCATGGTGTATAGCATCGTCAAGTACCAGCCCTCGGAGTATGGCAGTTACCGCTTCCCGCCCTGGGC
TGAGCTGCTGGGCATCCTGATGGGCCTGCTGTCCTGCCTCATGATCCCAGCTGGCATGCTGGTGGCTGTGCTTCGAGAAGAGGGCTCACT
CTGGGAGCGGCTCCAACAGGCCAGCCGGCCGGCCATGGACTGGGGACCATCGCTGGAGGAGAACCGGACGGGCATGTATGTGGCCACGCT
GGCTGGGAGCCAGTCACCAAAGCCACTGATGGTGCACATGCGCAAGGGCACATCTGCTAGGGGTCTTCTCTATGCAAGAATGACAGTATC
TGCCACGTACATCCGGAGCACGGACAAGATGCTGTCCTGCCTTCAAGGAGCACACAGTTCTGCAGAAACTTGCTTAGGTGACTTCAAACC
AGAGATCTGTGGTGAGGAAGTGACGGTGGTGGGGTGATGACATGGGAGAATTCCAGCAAAATCCACCTGGGAGAACCAGCAGCTCCACTC
CACGGACAGAGTGGATCTCTGCGGCACAGCAACGCAGCGACCCCAGCCTGGTCCCTCAGCTGTAAGACACACACGGGGTGCTTCTCAGGG

>50494_50494_2_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000379380_SLC6A7_chr5_149574291_ENST00000524041_length(amino acids)=682AA_BP=27
MVAERRGYSTALEVAAAVRRAMGRAVKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGA
FLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTE
LCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL
LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSV
LGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM
YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPS
EYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKGTSA

--------------------------------------------------------------
>50494_50494_3_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000507584_SLC6A7_chr5_149574291_ENST00000230671_length(transcript)=3385nt_BP=50nt
CTCTGGAGGTAGCGGCCGCGGTGAGGAGAGCCATGGGACGGGCAGTCAAGCCTGTCACCCCAGACCTGCTGATGACCCCCAGTGACCAGG
GCGATGTCGACCTGGATGTGGACTTTGCTGCACACCGGGGGAACTGGACAGGCAAGCTGGACTTCCTGCTGTCCTGCATTGGCTACTGTG
TAGGCCTGGGGAATGTCTGGCGCTTCCCCTATCGAGCGTACACCAATGGAGGAGGCGCCTTCCTCGTGCCCTACTTCCTCATGCTGGCCA
TCTGTGGCATCCCCCTCTTCTTCCTGGAGCTCTCCCTGGGCCAGTTCTCCAGCCTAGGGCCCCTGGCTGTCTGGAAAATCAGCCCTCTCT
TCAAAGGCGCCGGCGCAGCCATGCTGCTCATCGTGGGCTTGGTGGCCATCTACTACAACATGATCATCGCCTACGTGCTCTTCTACCTCT
TCGCCTCCCTCACCAGCGACCTACCCTGGGAGCACTGTGGCAACTGGTGGAACACAGAACTCTGCCTGGAGCACAGAGTCTCCAAGGACG
GCAACGGGGCCCTGCCCCTCAACCTCACCTGCACCGTCAGCCCCAGCGAGGAGTACTGGAGCCGCTACGTCCTCCACATCCAAGGCAGCC
AGGGCATCGGCAGCCCTGGGGAGATCCGCTGGAACCTCTGCCTCTGCCTGCTGCTGGCCTGGGTCATCGTGTTCCTCTGTATCCTCAAGG
GTGTGAAGTCTTCGGGCAAGGTGGTGTATTTCACGGCCACGTTCCCCTACCTCATCCTGCTCATGCTGCTGGTCCGCGGAGTCACCCTCC
CAGGGGCCTGGAAGGGCATCCAGTTCTATCTCACCCCCCAGTTCCACCACTTGTTGTCTTCCAAGGTGTGGATTGAAGCTGCTCTTCAGA
TCTTCTATTCCCTGGGTGTGGGCTTCGGGGGGCTCCTCACCTTTGCCTCCTACAACACGTTTCACCAGAACATCTATAGAGACACTTTCA
TCGTCACTCTGGGCAACGCCATCACCAGCATCCTGGCTGGCTTTGCCATCTTCTCCGTGCTGGGCTACATGTCTCAGGAGCTGGGCGTGC
CTGTGGACCAAGTAGCCAAAGCAGGCCCTGGCCTGGCCTTTGTCGTCTACCCACAGGCCATGACCATGCTGCCTCTGTCACCCTTCTGGT
CCTTTCTCTTCTTCTTCATGCTTCTGACTCTCGGCCTAGATAGCCAGTTTGCTTTTCTGGAGACCATTGTGACAGCTGTGACAGATGAGT
TCCCATACTACCTGCGGCCCAAGAAGGCGGTGTTCTCAGGGCTCATCTGCGTGGCCATGTACCTGATGGGGCTGATCCTCACCACTGATG
GGGGCATGTACTGGCTGGTCCTTCTGGATGACTACAGCGCCAGCTTCGGGCTGATGGTGGTGGTTATCACCACGTGCCTTGCCGTGACAC
GGGTGTATGGCATTCAGAGGTTCTGCCGAGACATCCACATGATGCTGGGCTTCAAGCCGGGCCTCTACTTCAGGGCCTGCTGGCTGTTCC
TGTCCCCAGCCACGCTCTTGGCCCTCATGGTGTATAGCATCGTCAAGTACCAGCCCTCGGAGTATGGCAGTTACCGCTTCCCGCCCTGGG
CTGAGCTGCTGGGCATCCTGATGGGCCTGCTGTCCTGCCTCATGATCCCAGCTGGCATGCTGGTGGCTGTGCTTCGAGAAGAGGGCTCAC
TCTGGGAGCGGCTCCAACAGGCCAGCCGGCCGGCCATGGACTGGGGACCATCGCTGGAGGAGAACCGGACGGGCATGTATGTGGCCACGC
TGGCTGGGAGCCAGTCACCAAAGCCACTGATGGTGCACATGCGCAAGTACGGGGGCATCACCAGCTTCGAGAACACGGCCATCGAGGTGG
ACCGTGAGATTGCAGAGGAGGAGGAGTCGATGATGTGAGGCAGGAGGCAGGCGGGCAGAAGGCCCTGCCCGGGACCTCACAGTCCCTTCT
TAGAAGCCTGCAAAGGTCAGCTGTGCCCTCTGGGATTCTGAGAGGCTATGGGGGGGCCTGCCATAGGGATGCCAGTCCCCCAGTGGGGGT
CCCTTCTGCAGCCTCTGCCTCTCCTGAAACCTCTGACAACCCCCTACACACACACACAGGCATACTCAGACCCACTCAAAGCTGAGAATG
ATCCAACTCAGCCCTACTTTGCGGATGGACATATTAAGGCCAGGAGGGGAGGGACTTGCCCCAGGTCGCATGGCAGAGGGGACTTGAACC
CACGCCTCCTGACCAGCCAGCTCCCTTTCCCATGGGGCAGCCGGCACCACCTTCTCATCTCTATTCAGGGCCTACACCCCTCCCTTTTTG
GGGGGAGCCTGTCCCCACACACCTTAGCACAACCAGAATCTTGAGTTGGGCAGGGAAGGTCAGGGCTACAGAGGCTCTTGAGGCTCCGAG
GCCCTGGGGATCAAAGGTCAATGAGTTAGGTGGGGAGAAAGATCCCTGGGGGCTCCTGTATGCAGGACTCCTGAAGGAGGTGGGAGCTGA
GGGCCCTGGAGGATGGGGAAGGTTTGCAGAGAGAGGAAGAAGAGGGCAGGGTGGGGAGGAGCTCTGGGCCAGAGGATGCTGAGCTGCCTG
GGCAGAGACCAAGAGGGTTGGAGACACTAGTTTTACCAGGTTACAGGAGGGTTCAAGACAGAAGGAAAACTAACAGAGGGGGAGCCAGGG
ATGATGGGGTGGGCAGGGGATTTGCATGATGAGGAGTATCATTCCAGATCTGTGCAGAGCGGATCGGACGGGACAGGGTGGAGCGGGGAG
GCCTGTGCAAAGTGGGAAAGAGCTGCCGGTGGCCTGAGCCAGGGTGCTGGGGCTGCGGGTGGGGAAAGGAGGCCCCAGCACTTCAGACAA
AGACCACCCCTTCACCCACTGGACCCCAAGCCGCAAAAGCTGGGGAGGTAGGAAGGGTCACTGTGAGGGCCCAGGGCCCCTCTCTTCCCA
TCTCCCTTGTCCTGGTGGCCTTCAGTGTCTCTTCCAGTTCCAGGAGCTGCTGGGAAGCTGGCCTTCATTGTTGGTGACAGGGCAACCATG
GGACTAGGAGGTGGCCCATACACATGGCTGGCTGGTCCTGAGGCCACCCACCTTGTTCCAGGACATGGGCCCGGGCCCGGTGTGGGGGTA
GACGCAGAGGGCAGAGGGTAGCCCTTGGTACTGTGGGTCCCTCAAAGAGGAGAGTGGGGTGCAGAAATGCCTCAGCATGGCTCATGCACA
CAGCATTCTCCCGTGGGGCAGGGTTCCCTCATGCAACAGGCCTCCCTGTGGCCAGCCTCTCTGCCTGTCTCTCGCTGCGTCCCCCCAACC

>50494_50494_3_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000507584_SLC6A7_chr5_149574291_ENST00000230671_length(amino acids)=641AA_BP=16
LEVAAAVRRAMGRAVKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAI
CGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDG
NGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLP
GAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVP
VDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDG
GMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWA
ELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGITSFENTAIEVD

--------------------------------------------------------------
>50494_50494_4_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000507584_SLC6A7_chr5_149574291_ENST00000524041_length(transcript)=2205nt_BP=50nt
CTCTGGAGGTAGCGGCCGCGGTGAGGAGAGCCATGGGACGGGCAGTCAAGCCTGTCACCCCAGACCTGCTGATGACCCCCAGTGACCAGG
GCGATGTCGACCTGGATGTGGACTTTGCTGCACACCGGGGGAACTGGACAGGCAAGCTGGACTTCCTGCTGTCCTGCATTGGCTACTGTG
TAGGCCTGGGGAATGTCTGGCGCTTCCCCTATCGAGCGTACACCAATGGAGGAGGCGCCTTCCTCGTGCCCTACTTCCTCATGCTGGCCA
TCTGTGGCATCCCCCTCTTCTTCCTGGAGCTCTCCCTGGGCCAGTTCTCCAGCCTAGGGCCCCTGGCTGTCTGGAAAATCAGCCCTCTCT
TCAAAGGCGCCGGCGCAGCCATGCTGCTCATCGTGGGCTTGGTGGCCATCTACTACAACATGATCATCGCCTACGTGCTCTTCTACCTCT
TCGCCTCCCTCACCAGCGACCTACCCTGGGAGCACTGTGGCAACTGGTGGAACACAGAACTCTGCCTGGAGCACAGAGTCTCCAAGGACG
GCAACGGGGCCCTGCCCCTCAACCTCACCTGCACCGTCAGCCCCAGCGAGGAGTACTGGAGCCGCTACGTCCTCCACATCCAAGGCAGCC
AGGGCATCGGCAGCCCTGGGGAGATCCGCTGGAACCTCTGCCTCTGCCTGCTGCTGGCCTGGGTCATCGTGTTCCTCTGTATCCTCAAGG
GTGTGAAGTCTTCGGGCAAGGTGGTGTATTTCACGGCCACGTTCCCCTACCTCATCCTGCTCATGCTGCTGGTCCGCGGAGTCACCCTCC
CAGGGGCCTGGAAGGGCATCCAGTTCTATCTCACCCCCCAGTTCCACCACTTGTTGTCTTCCAAGGTGTGGATTGAAGCTGCTCTTCAGA
TCTTCTATTCCCTGGGTGTGGGCTTCGGGGGGCTCCTCACCTTTGCCTCCTACAACACGTTTCACCAGAACATCTATAGAGACACTTTCA
TCGTCACTCTGGGCAACGCCATCACCAGCATCCTGGCTGGCTTTGCCATCTTCTCCGTGCTGGGCTACATGTCTCAGGAGCTGGGCGTGC
CTGTGGACCAAGTAGCCAAAGCAGGCCCTGGCCTGGCCTTTGTCGTCTACCCACAGGCCATGACCATGCTGCCTCTGTCACCCTTCTGGT
CCTTTCTCTTCTTCTTCATGCTTCTGACTCTCGGCCTAGATAGCCAGTTTGCTTTTCTGGAGACCATTGTGACAGCTGTGACAGATGAGT
TCCCATACTACCTGCGGCCCAAGAAGGCGGTGTTCTCAGGGCTCATCTGCGTGGCCATGTACCTGATGGGGCTGATCCTCACCACTGATG
GGGGCATGTACTGGCTGGTCCTTCTGGATGACTACAGCGCCAGCTTCGGGCTGATGGTGGTGGTTATCACCACGTGCCTTGCCGTGACAC
GGGTGTATGGCATTCAGAGGTTCTGCCGAGACATCCACATGATGCTGGGCTTCAAGCCGGGCCTCTACTTCAGGGCCTGCTGGCTGTTCC
TGTCCCCAGCCACGCTCTTGGCCCTCATGGTGTATAGCATCGTCAAGTACCAGCCCTCGGAGTATGGCAGTTACCGCTTCCCGCCCTGGG
CTGAGCTGCTGGGCATCCTGATGGGCCTGCTGTCCTGCCTCATGATCCCAGCTGGCATGCTGGTGGCTGTGCTTCGAGAAGAGGGCTCAC
TCTGGGAGCGGCTCCAACAGGCCAGCCGGCCGGCCATGGACTGGGGACCATCGCTGGAGGAGAACCGGACGGGCATGTATGTGGCCACGC
TGGCTGGGAGCCAGTCACCAAAGCCACTGATGGTGCACATGCGCAAGGGCACATCTGCTAGGGGTCTTCTCTATGCAAGAATGACAGTAT
CTGCCACGTACATCCGGAGCACGGACAAGATGCTGTCCTGCCTTCAAGGAGCACACAGTTCTGCAGAAACTTGCTTAGGTGACTTCAAAC
CAGAGATCTGTGGTGAGGAAGTGACGGTGGTGGGGTGATGACATGGGAGAATTCCAGCAAAATCCACCTGGGAGAACCAGCAGCTCCACT
CCACGGACAGAGTGGATCTCTGCGGCACAGCAACGCAGCGACCCCAGCCTGGTCCCTCAGCTGTAAGACACACACGGGGTGCTTCTCAGG

>50494_50494_4_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000507584_SLC6A7_chr5_149574291_ENST00000524041_length(amino acids)=671AA_BP=16
LEVAAAVRRAMGRAVKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAI
CGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDG
NGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLP
GAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVP
VDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDG
GMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWA
ELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKGTSARGLLYARMTVS

--------------------------------------------------------------
>50494_50494_5_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000510516_SLC6A7_chr5_149574291_ENST00000230671_length(transcript)=3430nt_BP=95nt
AGTTCAGTCTTTGATTGGTTGCTGAGAGGCGGGGCTACTCGACTGCTCTGGAGGTAGCGGCCGCGGTGAGGAGAGCCATGGGACGGGCAG
TCAAGCCTGTCACCCCAGACCTGCTGATGACCCCCAGTGACCAGGGCGATGTCGACCTGGATGTGGACTTTGCTGCACACCGGGGGAACT
GGACAGGCAAGCTGGACTTCCTGCTGTCCTGCATTGGCTACTGTGTAGGCCTGGGGAATGTCTGGCGCTTCCCCTATCGAGCGTACACCA
ATGGAGGAGGCGCCTTCCTCGTGCCCTACTTCCTCATGCTGGCCATCTGTGGCATCCCCCTCTTCTTCCTGGAGCTCTCCCTGGGCCAGT
TCTCCAGCCTAGGGCCCCTGGCTGTCTGGAAAATCAGCCCTCTCTTCAAAGGCGCCGGCGCAGCCATGCTGCTCATCGTGGGCTTGGTGG
CCATCTACTACAACATGATCATCGCCTACGTGCTCTTCTACCTCTTCGCCTCCCTCACCAGCGACCTACCCTGGGAGCACTGTGGCAACT
GGTGGAACACAGAACTCTGCCTGGAGCACAGAGTCTCCAAGGACGGCAACGGGGCCCTGCCCCTCAACCTCACCTGCACCGTCAGCCCCA
GCGAGGAGTACTGGAGCCGCTACGTCCTCCACATCCAAGGCAGCCAGGGCATCGGCAGCCCTGGGGAGATCCGCTGGAACCTCTGCCTCT
GCCTGCTGCTGGCCTGGGTCATCGTGTTCCTCTGTATCCTCAAGGGTGTGAAGTCTTCGGGCAAGGTGGTGTATTTCACGGCCACGTTCC
CCTACCTCATCCTGCTCATGCTGCTGGTCCGCGGAGTCACCCTCCCAGGGGCCTGGAAGGGCATCCAGTTCTATCTCACCCCCCAGTTCC
ACCACTTGTTGTCTTCCAAGGTGTGGATTGAAGCTGCTCTTCAGATCTTCTATTCCCTGGGTGTGGGCTTCGGGGGGCTCCTCACCTTTG
CCTCCTACAACACGTTTCACCAGAACATCTATAGAGACACTTTCATCGTCACTCTGGGCAACGCCATCACCAGCATCCTGGCTGGCTTTG
CCATCTTCTCCGTGCTGGGCTACATGTCTCAGGAGCTGGGCGTGCCTGTGGACCAAGTAGCCAAAGCAGGCCCTGGCCTGGCCTTTGTCG
TCTACCCACAGGCCATGACCATGCTGCCTCTGTCACCCTTCTGGTCCTTTCTCTTCTTCTTCATGCTTCTGACTCTCGGCCTAGATAGCC
AGTTTGCTTTTCTGGAGACCATTGTGACAGCTGTGACAGATGAGTTCCCATACTACCTGCGGCCCAAGAAGGCGGTGTTCTCAGGGCTCA
TCTGCGTGGCCATGTACCTGATGGGGCTGATCCTCACCACTGATGGGGGCATGTACTGGCTGGTCCTTCTGGATGACTACAGCGCCAGCT
TCGGGCTGATGGTGGTGGTTATCACCACGTGCCTTGCCGTGACACGGGTGTATGGCATTCAGAGGTTCTGCCGAGACATCCACATGATGC
TGGGCTTCAAGCCGGGCCTCTACTTCAGGGCCTGCTGGCTGTTCCTGTCCCCAGCCACGCTCTTGGCCCTCATGGTGTATAGCATCGTCA
AGTACCAGCCCTCGGAGTATGGCAGTTACCGCTTCCCGCCCTGGGCTGAGCTGCTGGGCATCCTGATGGGCCTGCTGTCCTGCCTCATGA
TCCCAGCTGGCATGCTGGTGGCTGTGCTTCGAGAAGAGGGCTCACTCTGGGAGCGGCTCCAACAGGCCAGCCGGCCGGCCATGGACTGGG
GACCATCGCTGGAGGAGAACCGGACGGGCATGTATGTGGCCACGCTGGCTGGGAGCCAGTCACCAAAGCCACTGATGGTGCACATGCGCA
AGTACGGGGGCATCACCAGCTTCGAGAACACGGCCATCGAGGTGGACCGTGAGATTGCAGAGGAGGAGGAGTCGATGATGTGAGGCAGGA
GGCAGGCGGGCAGAAGGCCCTGCCCGGGACCTCACAGTCCCTTCTTAGAAGCCTGCAAAGGTCAGCTGTGCCCTCTGGGATTCTGAGAGG
CTATGGGGGGGCCTGCCATAGGGATGCCAGTCCCCCAGTGGGGGTCCCTTCTGCAGCCTCTGCCTCTCCTGAAACCTCTGACAACCCCCT
ACACACACACACAGGCATACTCAGACCCACTCAAAGCTGAGAATGATCCAACTCAGCCCTACTTTGCGGATGGACATATTAAGGCCAGGA
GGGGAGGGACTTGCCCCAGGTCGCATGGCAGAGGGGACTTGAACCCACGCCTCCTGACCAGCCAGCTCCCTTTCCCATGGGGCAGCCGGC
ACCACCTTCTCATCTCTATTCAGGGCCTACACCCCTCCCTTTTTGGGGGGAGCCTGTCCCCACACACCTTAGCACAACCAGAATCTTGAG
TTGGGCAGGGAAGGTCAGGGCTACAGAGGCTCTTGAGGCTCCGAGGCCCTGGGGATCAAAGGTCAATGAGTTAGGTGGGGAGAAAGATCC
CTGGGGGCTCCTGTATGCAGGACTCCTGAAGGAGGTGGGAGCTGAGGGCCCTGGAGGATGGGGAAGGTTTGCAGAGAGAGGAAGAAGAGG
GCAGGGTGGGGAGGAGCTCTGGGCCAGAGGATGCTGAGCTGCCTGGGCAGAGACCAAGAGGGTTGGAGACACTAGTTTTACCAGGTTACA
GGAGGGTTCAAGACAGAAGGAAAACTAACAGAGGGGGAGCCAGGGATGATGGGGTGGGCAGGGGATTTGCATGATGAGGAGTATCATTCC
AGATCTGTGCAGAGCGGATCGGACGGGACAGGGTGGAGCGGGGAGGCCTGTGCAAAGTGGGAAAGAGCTGCCGGTGGCCTGAGCCAGGGT
GCTGGGGCTGCGGGTGGGGAAAGGAGGCCCCAGCACTTCAGACAAAGACCACCCCTTCACCCACTGGACCCCAAGCCGCAAAAGCTGGGG
AGGTAGGAAGGGTCACTGTGAGGGCCCAGGGCCCCTCTCTTCCCATCTCCCTTGTCCTGGTGGCCTTCAGTGTCTCTTCCAGTTCCAGGA
GCTGCTGGGAAGCTGGCCTTCATTGTTGGTGACAGGGCAACCATGGGACTAGGAGGTGGCCCATACACATGGCTGGCTGGTCCTGAGGCC
ACCCACCTTGTTCCAGGACATGGGCCCGGGCCCGGTGTGGGGGTAGACGCAGAGGGCAGAGGGTAGCCCTTGGTACTGTGGGTCCCTCAA
AGAGGAGAGTGGGGTGCAGAAATGCCTCAGCATGGCTCATGCACACAGCATTCTCCCGTGGGGCAGGGTTCCCTCATGCAACAGGCCTCC
CTGTGGCCAGCCTCTCTGCCTGTCTCTCGCTGCGTCCCCCCAACCCCTTGTGTTCTATTGGTTCATTGTTAATAAATATCAAATGAGGTC

>50494_50494_5_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000510516_SLC6A7_chr5_149574291_ENST00000230671_length(amino acids)=652AA_BP=27
MVAERRGYSTALEVAAAVRRAMGRAVKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGA
FLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTE
LCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL
LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSV
LGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM
YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPS
EYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGI

--------------------------------------------------------------
>50494_50494_6_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000510516_SLC6A7_chr5_149574291_ENST00000524041_length(transcript)=2250nt_BP=95nt
AGTTCAGTCTTTGATTGGTTGCTGAGAGGCGGGGCTACTCGACTGCTCTGGAGGTAGCGGCCGCGGTGAGGAGAGCCATGGGACGGGCAG
TCAAGCCTGTCACCCCAGACCTGCTGATGACCCCCAGTGACCAGGGCGATGTCGACCTGGATGTGGACTTTGCTGCACACCGGGGGAACT
GGACAGGCAAGCTGGACTTCCTGCTGTCCTGCATTGGCTACTGTGTAGGCCTGGGGAATGTCTGGCGCTTCCCCTATCGAGCGTACACCA
ATGGAGGAGGCGCCTTCCTCGTGCCCTACTTCCTCATGCTGGCCATCTGTGGCATCCCCCTCTTCTTCCTGGAGCTCTCCCTGGGCCAGT
TCTCCAGCCTAGGGCCCCTGGCTGTCTGGAAAATCAGCCCTCTCTTCAAAGGCGCCGGCGCAGCCATGCTGCTCATCGTGGGCTTGGTGG
CCATCTACTACAACATGATCATCGCCTACGTGCTCTTCTACCTCTTCGCCTCCCTCACCAGCGACCTACCCTGGGAGCACTGTGGCAACT
GGTGGAACACAGAACTCTGCCTGGAGCACAGAGTCTCCAAGGACGGCAACGGGGCCCTGCCCCTCAACCTCACCTGCACCGTCAGCCCCA
GCGAGGAGTACTGGAGCCGCTACGTCCTCCACATCCAAGGCAGCCAGGGCATCGGCAGCCCTGGGGAGATCCGCTGGAACCTCTGCCTCT
GCCTGCTGCTGGCCTGGGTCATCGTGTTCCTCTGTATCCTCAAGGGTGTGAAGTCTTCGGGCAAGGTGGTGTATTTCACGGCCACGTTCC
CCTACCTCATCCTGCTCATGCTGCTGGTCCGCGGAGTCACCCTCCCAGGGGCCTGGAAGGGCATCCAGTTCTATCTCACCCCCCAGTTCC
ACCACTTGTTGTCTTCCAAGGTGTGGATTGAAGCTGCTCTTCAGATCTTCTATTCCCTGGGTGTGGGCTTCGGGGGGCTCCTCACCTTTG
CCTCCTACAACACGTTTCACCAGAACATCTATAGAGACACTTTCATCGTCACTCTGGGCAACGCCATCACCAGCATCCTGGCTGGCTTTG
CCATCTTCTCCGTGCTGGGCTACATGTCTCAGGAGCTGGGCGTGCCTGTGGACCAAGTAGCCAAAGCAGGCCCTGGCCTGGCCTTTGTCG
TCTACCCACAGGCCATGACCATGCTGCCTCTGTCACCCTTCTGGTCCTTTCTCTTCTTCTTCATGCTTCTGACTCTCGGCCTAGATAGCC
AGTTTGCTTTTCTGGAGACCATTGTGACAGCTGTGACAGATGAGTTCCCATACTACCTGCGGCCCAAGAAGGCGGTGTTCTCAGGGCTCA
TCTGCGTGGCCATGTACCTGATGGGGCTGATCCTCACCACTGATGGGGGCATGTACTGGCTGGTCCTTCTGGATGACTACAGCGCCAGCT
TCGGGCTGATGGTGGTGGTTATCACCACGTGCCTTGCCGTGACACGGGTGTATGGCATTCAGAGGTTCTGCCGAGACATCCACATGATGC
TGGGCTTCAAGCCGGGCCTCTACTTCAGGGCCTGCTGGCTGTTCCTGTCCCCAGCCACGCTCTTGGCCCTCATGGTGTATAGCATCGTCA
AGTACCAGCCCTCGGAGTATGGCAGTTACCGCTTCCCGCCCTGGGCTGAGCTGCTGGGCATCCTGATGGGCCTGCTGTCCTGCCTCATGA
TCCCAGCTGGCATGCTGGTGGCTGTGCTTCGAGAAGAGGGCTCACTCTGGGAGCGGCTCCAACAGGCCAGCCGGCCGGCCATGGACTGGG
GACCATCGCTGGAGGAGAACCGGACGGGCATGTATGTGGCCACGCTGGCTGGGAGCCAGTCACCAAAGCCACTGATGGTGCACATGCGCA
AGGGCACATCTGCTAGGGGTCTTCTCTATGCAAGAATGACAGTATCTGCCACGTACATCCGGAGCACGGACAAGATGCTGTCCTGCCTTC
AAGGAGCACACAGTTCTGCAGAAACTTGCTTAGGTGACTTCAAACCAGAGATCTGTGGTGAGGAAGTGACGGTGGTGGGGTGATGACATG
GGAGAATTCCAGCAAAATCCACCTGGGAGAACCAGCAGCTCCACTCCACGGACAGAGTGGATCTCTGCGGCACAGCAACGCAGCGACCCC
AGCCTGGTCCCTCAGCTGTAAGACACACACGGGGTGCTTCTCAGGGCATGGTGTTTCCTGCTTGGGCAACCCACCCACCCTGCCGCTTTA

>50494_50494_6_LYRM7-SLC6A7_LYRM7_chr5_130506731_ENST00000510516_SLC6A7_chr5_149574291_ENST00000524041_length(amino acids)=682AA_BP=27
MVAERRGYSTALEVAAAVRRAMGRAVKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGA
FLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTE
LCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL
LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSV
LGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM
YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPS
EYGSYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKGTSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for LYRM7-SLC6A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LYRM7-SLC6A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LYRM7-SLC6A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource