FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LYZ-CEACAM5 (FusionGDB2 ID:50527)

Fusion Gene Summary for LYZ-CEACAM5

check button Fusion gene summary
Fusion gene informationFusion gene name: LYZ-CEACAM5
Fusion gene ID: 50527
HgeneTgene
Gene symbol

LYZ

CEACAM5

Gene ID

4069

1048

Gene namelysozymeCEA cell adhesion molecule 5
SynonymsLYZF1|LZMCD66e|CEA
Cytomap

12q15

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionlysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1carcinoembryonic antigen-related cell adhesion molecule 5carcinoembryonic antigen related cell adhesion molecule 5meconium antigen 100
Modification date2020031320200313
UniProtAcc

P61626

P06731

Ensembl transtripts involved in fusion geneENST00000261267, ENST00000549690, 
ENST00000548839, 		ENST00000221992, 
ENST00000398599, ENST00000405816, 
Fusion gene scores* DoF score36 X 29 X 8=835211 X 16 X 6=1056
# samples 3314
** MAII scorelog2(33/8352*10)=-4.66158378232407
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1056*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LYZ [Title/Abstract] AND CEACAM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLYZ(69747259)-CEACAM5(42233371), # samples:4
CEACAM5(42225089)-LYZ(69747485), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLYZ

GO:0031640

killing of cells of other organism

9727055

HgeneLYZ

GO:0042742

defense response to bacterium

21093056

HgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056

TgeneCEACAM5

GO:0010832

negative regulation of myotube differentiation

8408226|10931872

TgeneCEACAM5

GO:0034109

homotypic cell-cell adhesion

10864933

TgeneCEACAM5

GO:0043066

negative regulation of apoptotic process

11448920

TgeneCEACAM5

GO:2000811

negative regulation of anoikis

10910050


check buttonFusion gene breakpoints across LYZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CEACAM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GHLYZchr12

69747259

+CEACAM5chr19

42233371

+
ChimerDB4ESCATCGA-2H-A9GHLYZchr12

69747266

+CEACAM5chr19

42233378

+
ChimerDB4ESCATCGA-L5-A8NWLYZchr12

69747266

+CEACAM5chr19

42233378

+
ChimerDB4STADTCGA-CD-8529-01ALYZchr12

69747259

+CEACAM5chr19

42233371

+
ChimerDB4STADTCGA-CD-8529-01ALYZchr12

69747266

+CEACAM5chr19

42233378

+
ChimerDB4STADTCGA-FP-A8CX-01ALYZchr12

69747259

+CEACAM5chr19

42233371

+
ChimerDB4STADTCGA-VQ-AA6D-01ALYZchr12

69747259

+CEACAM5chr19

42233371

+


Top

Fusion Gene ORF analysis for LYZ-CEACAM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000261267ENST00000221992LYZchr12

69747259

+CEACAM5chr19

42233371

+
3UTR-3UTRENST00000261267ENST00000221992LYZchr12

69747266

+CEACAM5chr19

42233378

+
3UTR-3UTRENST00000549690ENST00000221992LYZchr12

69747259

+CEACAM5chr19

42233371

+
3UTR-3UTRENST00000549690ENST00000221992LYZchr12

69747266

+CEACAM5chr19

42233378

+
3UTR-intronENST00000261267ENST00000398599LYZchr12

69747259

+CEACAM5chr19

42233371

+
3UTR-intronENST00000261267ENST00000398599LYZchr12

69747266

+CEACAM5chr19

42233378

+
3UTR-intronENST00000261267ENST00000405816LYZchr12

69747259

+CEACAM5chr19

42233371

+
3UTR-intronENST00000261267ENST00000405816LYZchr12

69747266

+CEACAM5chr19

42233378

+
3UTR-intronENST00000549690ENST00000398599LYZchr12

69747259

+CEACAM5chr19

42233371

+
3UTR-intronENST00000549690ENST00000398599LYZchr12

69747266

+CEACAM5chr19

42233378

+
3UTR-intronENST00000549690ENST00000405816LYZchr12

69747259

+CEACAM5chr19

42233371

+
3UTR-intronENST00000549690ENST00000405816LYZchr12

69747266

+CEACAM5chr19

42233378

+
intron-3UTRENST00000548839ENST00000221992LYZchr12

69747259

+CEACAM5chr19

42233371

+
intron-3UTRENST00000548839ENST00000221992LYZchr12

69747266

+CEACAM5chr19

42233378

+
intron-intronENST00000548839ENST00000398599LYZchr12

69747259

+CEACAM5chr19

42233371

+
intron-intronENST00000548839ENST00000398599LYZchr12

69747266

+CEACAM5chr19

42233378

+
intron-intronENST00000548839ENST00000405816LYZchr12

69747259

+CEACAM5chr19

42233371

+
intron-intronENST00000548839ENST00000405816LYZchr12

69747266

+CEACAM5chr19

42233378

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for LYZ-CEACAM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LYZ-CEACAM5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69747259/:42233371)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYZ

P61626

CEACAM5

P06731

FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}.; FUNCTION: (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for LYZ-CEACAM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for LYZ-CEACAM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LYZ-CEACAM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LYZ-CEACAM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource