FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:LYZ-LARS (FusionGDB2 ID:50538)

Fusion Gene Summary for LYZ-LARS

check button Fusion gene summary
Fusion gene informationFusion gene name: LYZ-LARS
Fusion gene ID: 50538
HgeneTgene
Gene symbol

LYZ

LARS

Gene ID

4069

51520

Gene namelysozymeleucyl-tRNA synthetase 1
SynonymsLYZF1|LZMHSPC192|ILFS1|LARS|LEURS|LEUS|LFIS|LRS|PIG44|RNTLS|hr025Cl
Cytomap

12q15

5q32

Type of geneprotein-codingprotein-coding
Descriptionlysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1leucine--tRNA ligase, cytoplasmiccytoplasmic leucyl-tRNA synthetasecytosolic leucyl-tRNA synthetaseleucine tRNA ligase 1, cytoplasmicleucine translaseproliferation-inducing gene 44
Modification date2020031320200313
UniProtAcc

P61626

Q15031

Ensembl transtripts involved in fusion geneENST00000261267, ENST00000548839, 
ENST00000549690, 		ENST00000511505, 
ENST00000274562, ENST00000394434, 
ENST00000510191, ENST00000545646, 
Fusion gene scores* DoF score36 X 29 X 8=835210 X 8 X 6=480
# samples 3310
** MAII scorelog2(33/8352*10)=-4.66158378232407
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LYZ [Title/Abstract] AND LARS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLYZ(69746078)-LARS(145519824), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLYZ

GO:0031640

killing of cells of other organism

9727055

HgeneLYZ

GO:0042742

defense response to bacterium

21093056

HgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056

TgeneLARS

GO:0006425

glutaminyl-tRNA aminoacylation

26869582


check buttonFusion gene breakpoints across LYZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LARS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer203NLYZchr12

69746078

+LARSchr5

145519824

-


Top

Fusion Gene ORF analysis for LYZ-LARS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261267ENST00000511505LYZchr12

69746078

+LARSchr5

145519824

-
In-frameENST00000261267ENST00000274562LYZchr12

69746078

+LARSchr5

145519824

-
In-frameENST00000261267ENST00000394434LYZchr12

69746078

+LARSchr5

145519824

-
In-frameENST00000261267ENST00000510191LYZchr12

69746078

+LARSchr5

145519824

-
In-frameENST00000261267ENST00000545646LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000548839ENST00000274562LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000548839ENST00000394434LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000548839ENST00000510191LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000548839ENST00000545646LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000549690ENST00000274562LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000549690ENST00000394434LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000549690ENST00000510191LYZchr12

69746078

+LARSchr5

145519824

-
intron-3CDSENST00000549690ENST00000545646LYZchr12

69746078

+LARSchr5

145519824

-
intron-intronENST00000548839ENST00000511505LYZchr12

69746078

+LARSchr5

145519824

-
intron-intronENST00000549690ENST00000511505LYZchr12

69746078

+LARSchr5

145519824

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261267LYZchr1269746078+ENST00000394434LARSchr5145519824-2957448681888606
ENST00000261267LYZchr1269746078+ENST00000545646LARSchr5145519824-2152448681888606
ENST00000261267LYZchr1269746078+ENST00000274562LARSchr5145519824-2084448681888606
ENST00000261267LYZchr1269746078+ENST00000510191LARSchr5145519824-2084448681888606

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261267ENST00000394434LYZchr1269746078+LARSchr5145519824-0.0005505080.99944943
ENST00000261267ENST00000545646LYZchr1269746078+LARSchr5145519824-0.0011363590.9988637
ENST00000261267ENST00000274562LYZchr1269746078+LARSchr5145519824-0.001325060.9986749
ENST00000261267ENST00000510191LYZchr1269746078+LARSchr5145519824-0.001325060.9986749

Top

Fusion Genomic Features for LYZ-LARS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for LYZ-LARS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69746078/chr5:145519824)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYZ

P61626

LARS

Q15031

FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLARSchr12:69746078chr5:145519824ENST000003944341932716_7206961177.0MotifNote='KMSKS' region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLYZchr12:69746078chr5:145519824ENST00000261267+3419_148126149.0DomainC-type lysozyme
TgeneLARSchr12:69746078chr5:145519824ENST00000394434193253_636961177.0MotifNote='HIGH' region
TgeneLARSchr12:69746078chr5:145519824ENST000003944341932260_5096961177.0RegionNote=Editing domain


Top

Fusion Gene Sequence for LYZ-LARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50538_50538_1_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000274562_length(transcript)=2084nt_BP=448nt
GTTAAAAGATGTTAAATACTGGGGCCAGCTCACCCTGGTCAGCCTAGCACTCTGACCTAGCAGTCAACATGAAGGCTCTCATTGTTCTGG
GGCTTGTCCTCCTTTCTGTTACGGTCCAGGGCAAGGTCTTTGAAAGGTGTGAGTTGGCCAGAACTCTGAAAAGATTGGGAATGGATGGCT
ACAGGGGAATCAGCCTAGCAAACTGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACA
GAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTAT
CCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGTG
ACAAATGGCCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGA
CCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAG
CCATGGCAGATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTC
CTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTA
AAGAAGCTTTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTG
TGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTG
ACTCAATTATGAATGCTTCATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATG
ACCTTAGACTACGACTCAAGAACTATATGATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCA
TCTATGTGGCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTG
ACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGG
AAAATCTGGAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGA
CTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCAC
TTAATGTTTTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCA
GGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGAT
TTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCA
ATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAA
CTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGA
CCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAAT

>50538_50538_1_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000274562_length(amino acids)=606AA_BP=127
MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPG
AVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRACDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTV
EDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPL
QKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDL

--------------------------------------------------------------
>50538_50538_2_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000394434_length(transcript)=2957nt_BP=448nt
GTTAAAAGATGTTAAATACTGGGGCCAGCTCACCCTGGTCAGCCTAGCACTCTGACCTAGCAGTCAACATGAAGGCTCTCATTGTTCTGG
GGCTTGTCCTCCTTTCTGTTACGGTCCAGGGCAAGGTCTTTGAAAGGTGTGAGTTGGCCAGAACTCTGAAAAGATTGGGAATGGATGGCT
ACAGGGGAATCAGCCTAGCAAACTGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACA
GAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTAT
CCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGTG
ACAAATGGCCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGA
CCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAG
CCATGGCAGATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTC
CTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTA
AAGAAGCTTTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTG
TGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTG
ACTCAATTATGAATGCTTCATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATG
ACCTTAGACTACGACTCAAGAACTATATGATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCA
TCTATGTGGCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTG
ACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGG
AAAATCTGGAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGA
CTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCAC
TTAATGTTTTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCA
GGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGAT
TTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCA
ATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAA
CTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGA
CCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAAT
TTTTTTTCCCTTTCTTTGGGTGTCCAAGAGAAATGGTTTTTGCCAAACTCTTTTTAAAAAACAAATTGTTGCTATTTCCTAGAAGTTTCT
GGTTTTTAAGATGAACATAAAAGTGTCAGTATGCTTCTTTTATGAGGTGTACTTTATACTTTGATGAAGGCTAAGGTGTACCTAACAGCT
TTTTATAGTATATTCATTTATGGAGTTAGCTGTATTTTTTTTTAAAAAAGAAAAGTAGTAAATTAGCAGCTTTTTTTTTTAAATGAAGAG
AACTTCATGATGATTTAAAAGAACTAATGAGAATATTTTGACTTGACTTCAATTACTAAGTATTTTGTATAAAGAACAAATAGGTCCTGC
ATTTTATAAGACTTTTTAAAGCTTTAATTATTCAACTAAGAACCAATAATGGCTTCTTCAAGGCTAATATCAATAGTTTATAAGCAGTAT
ATTTCACCTACACTAAATATGGGCATTTTAAAAGAAGATTCCCCCCTTCCCCCCCAGAAATCTGCATTTACTAAATTTGTCTTAAGTCCA
ATTGTGTTTAAAGGTCATGCTGGTCGGGTGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGTCACCTGAGG
TCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTTGGCATGGTGGCGGGTACCTG
TAATCCCAGCTGCTTGGGAGTGTGAGGCAGGAGAATCGCTTGAACCTGGGAGACCGAGGTTGCAGTGAGCTGAAACCGTGCCATTGCACT

>50538_50538_2_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000394434_length(amino acids)=606AA_BP=127
MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPG
AVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRACDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTV
EDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPL
QKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDL

--------------------------------------------------------------
>50538_50538_3_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000510191_length(transcript)=2084nt_BP=448nt
GTTAAAAGATGTTAAATACTGGGGCCAGCTCACCCTGGTCAGCCTAGCACTCTGACCTAGCAGTCAACATGAAGGCTCTCATTGTTCTGG
GGCTTGTCCTCCTTTCTGTTACGGTCCAGGGCAAGGTCTTTGAAAGGTGTGAGTTGGCCAGAACTCTGAAAAGATTGGGAATGGATGGCT
ACAGGGGAATCAGCCTAGCAAACTGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACA
GAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTAT
CCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGTG
ACAAATGGCCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGA
CCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAG
CCATGGCAGATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTC
CTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTA
AAGAAGCTTTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTG
TGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTG
ACTCAATTATGAATGCTTCATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATG
ACCTTAGACTACGACTCAAGAACTATATGATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCA
TCTATGTGGCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTG
ACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGG
AAAATCTGGAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGA
CTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCAC
TTAATGTTTTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCA
GGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGAT
TTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCA
ATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAA
CTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGA
CCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAAT

>50538_50538_3_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000510191_length(amino acids)=606AA_BP=127
MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPG
AVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRACDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTV
EDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPL
QKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDL

--------------------------------------------------------------
>50538_50538_4_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000545646_length(transcript)=2152nt_BP=448nt
GTTAAAAGATGTTAAATACTGGGGCCAGCTCACCCTGGTCAGCCTAGCACTCTGACCTAGCAGTCAACATGAAGGCTCTCATTGTTCTGG
GGCTTGTCCTCCTTTCTGTTACGGTCCAGGGCAAGGTCTTTGAAAGGTGTGAGTTGGCCAGAACTCTGAAAAGATTGGGAATGGATGGCT
ACAGGGGAATCAGCCTAGCAAACTGGATGTGTTTGGCCAAATGGGAGAGTGGTTACAACACACGAGCTACAAACTACAATGCTGGAGACA
GAAGCACTGATTATGGGATATTTCAGATCAATAGCCGCTACTGGTGTAATGATGGCAAAACCCCAGGAGCAGTTAATGCCTGTCATTTAT
CCTGCAGTGCTTTGCTGCAAGATAACATCGCTGATGCTGTAGCTTGTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGTG
ACAAATGGCCTACAGCTGTGAGAGCAAATGGACATCTCCTCCTGAACTCTGAGAAGATGTCAAAATCCACAGGCAACTTCCTCACTTTGA
CCCAAGCTATTGACAAATTTTCAGCAGATGGAATGCGTTTGGCTCTGGCTGATGCTGGTGACACTGTAGAAGATGCCAACTTTGTGGAAG
CCATGGCAGATGCAGGTATTCTCCGTCTGTACACCTGGGTAGAGTGGGTGAAAGAAATGGTTGCCAACTGGGACAGCCTAAGAAGTGGTC
CTGCCAGCACTTTCAATGATAGAGTTTTTGCCAGTGAATTGAATGCAGGAATTATAAAAACAGATCAAAACTATGAAAAGATGATGTTTA
AAGAAGCTTTGAAAACAGGGTTTTTTGAGTTTCAGGCCGCAAAAGATAAGTACCGTGAATTGGCTGTGGAAGGGATGCACAGAGAACTTG
TGTTCCGGTTTATTGAAGTTCAGACACTTCTCCTCGCTCCATTCTGTCCACATTTGTGTGAGCACATCTGGACACTCCTGGGAAAGCCTG
ACTCAATTATGAATGCTTCATGGCCTGTGGCAGGTCCTGTTAATGAAGTTTTAATACACTCCTCACAGTATCTTATGGAAGTAACACATG
ACCTTAGACTACGACTCAAGAACTATATGATGCCAGCTAAAGGGAAGAAGACTGACAAACAACCCCTGCAGAAGCCCTCACATTGCACCA
TCTATGTGGCAAAGAACTATCCACCTTGGCAACATACCACCCTGTCTGTTCTACGTAAACACTTTGAGGCCAATAACGGAAAACTGCCTG
ACAACAAAGTCATTGCTAGTGAACTAGGCAGTATGCCAGAACTGAAGAAATACATGAAGAAAGTCATGCCATTTGTTGCCATGATTAAGG
AAAATCTGGAGAAGATGGGGCCTCGTATTCTGGATTTGCAATTAGAATTTGATGAAAAGGCTGTGCTTATGGAGAATATAGTCTATCTGA
CTAATTCGCTTGAGCTAGAACACATAGAAGTCAAGTTTGCCTCCGAAGCAGAAGATAAAATCAGGGAAGACTGCTGTCCTGGGAAACCAC
TTAATGTTTTTAGAATAGAACCTGGTGTGTCCGTTTCTCTGGTGAATCCCCAGCCATCCAATGGCCACTTCTCAACCAAAATTGAAATCA
GGCAAGGAGATAACTGTGATTCCATAATCAGGCGTTTAATGAAAATGAATCGAGGAATTAAAGACCTTTCCAAAGTGAAACTGATGAGAT
TTGATGATCCACTGTTGGGGCCTCGACGAGTTCCTGTCCTGGGAAAGGAGTACACCGAGAAGACCCCCATTTCTGAGCATGCTGTTTTCA
ATGTGGACCTCATGAGCAAGAAAATTCATCTGACTGAGAATGGGATAAGGGTGGATATTGGCGATACAATAATCTATCTGGTTCATTAAA
CTCATGCACATTGGAGATTTATCCTGGTTTCTTAGGAATACTACTACTCTGATTGTGTCTACTGATTGGCTATCAGAACCTTAGGCTGGA
CCTAAATAGATTGATTTCATTTCTAACCATCCAATTCTGCATGTATTCATAATTCTATCAAGTCATCTTTGATTCCTGGACCTAATAAAT

>50538_50538_4_LYZ-LARS_LYZ_chr12_69746078_ENST00000261267_LARS_chr5_145519824_ENST00000545646_length(amino acids)=606AA_BP=127
MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPG
AVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRACDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTV
EDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPL
QKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for LYZ-LARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for LYZ-LARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for LYZ-LARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource