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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANXA4-PKN1 (FusionGDB2 ID:5064)

Fusion Gene Summary for ANXA4-PKN1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANXA4-PKN1
Fusion gene ID: 5064
HgeneTgene
Gene symbol

ANXA4

PKN1

Gene ID

307

5585

Gene nameannexin A4protein kinase N1
SynonymsANX4|HEL-S-274|P32.5|PAP-II|PIG28|PP4-X|ZAP36DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1
Cytomap

2p13.3

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionannexin A435-beta calcimedinannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferation-induserine/threonine-protein kinase N1protease-activated kinase 1protein kinase C-like 1protein kinase C-like PKNprotein kinase C-related kinase 1protein kinase PKN-alphaserine-threonine kinase Nserine/threonine protein kinase N
Modification date2020031320200329
UniProtAcc

P09525

.
Ensembl transtripts involved in fusion geneENST00000394295, ENST00000409920, 
ENST00000536030, ENST00000418066, 
ENST00000342216, ENST00000587429, 
ENST00000242783, 
Fusion gene scores* DoF score14 X 12 X 7=11767 X 11 X 6=462
# samples 1612
** MAII scorelog2(16/1176*10)=-2.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/462*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANXA4 [Title/Abstract] AND PKN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANXA4(70008706)-PKN1(14578377), # samples:3
PKN1(14574965)-ANXA4(70015186), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANXA4

GO:0006357

regulation of transcription by RNA polymerase II

20237821

HgeneANXA4

GO:0032088

negative regulation of NF-kappaB transcription factor activity

20237821

TgenePKN1

GO:0006357

regulation of transcription by RNA polymerase II

12514133

TgenePKN1

GO:0006468

protein phosphorylation

17332740

TgenePKN1

GO:0035407

histone H3-T11 phosphorylation

18066052


check buttonFusion gene breakpoints across ANXA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PKN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-4072-01BANXA4chr2

70008706

-PKN1chr19

14578377

+
ChimerDB4LIHCTCGA-BC-4072-01BANXA4chr2

70008706

+PKN1chr19

14578377

+
ChimerDB4LIHCTCGA-BC-4072ANXA4chr2

70008706

+PKN1chr19

14578376

+


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Fusion Gene ORF analysis for ANXA4-PKN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000394295ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578377

+
5CDS-intronENST00000394295ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578376

+
5CDS-intronENST00000394295ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578377

+
5CDS-intronENST00000394295ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578376

+
5CDS-intronENST00000409920ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578377

+
5CDS-intronENST00000409920ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578376

+
5CDS-intronENST00000409920ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578377

+
5CDS-intronENST00000409920ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578376

+
5UTR-3CDSENST00000536030ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578377

+
5UTR-3CDSENST00000536030ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578376

+
5UTR-intronENST00000536030ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578377

+
5UTR-intronENST00000536030ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578376

+
5UTR-intronENST00000536030ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578377

+
5UTR-intronENST00000536030ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578376

+
In-frameENST00000394295ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578377

+
In-frameENST00000394295ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578376

+
In-frameENST00000409920ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578377

+
In-frameENST00000409920ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578376

+
intron-3CDSENST00000418066ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578377

+
intron-3CDSENST00000418066ENST00000242783ANXA4chr2

70008706

+PKN1chr19

14578376

+
intron-intronENST00000418066ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578377

+
intron-intronENST00000418066ENST00000342216ANXA4chr2

70008706

+PKN1chr19

14578376

+
intron-intronENST00000418066ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578377

+
intron-intronENST00000418066ENST00000587429ANXA4chr2

70008706

+PKN1chr19

14578376

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409920ANXA4chr270008706+ENST00000242783PKN1chr1914578377+14302572481354368
ENST00000394295ANXA4chr270008706+ENST00000242783PKN1chr1914578377+14302572481354368
ENST00000409920ANXA4chr270008706+ENST00000242783PKN1chr1914578376+14302572481354368
ENST00000394295ANXA4chr270008706+ENST00000242783PKN1chr1914578376+14302572481354368

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409920ENST00000242783ANXA4chr270008706+PKN1chr1914578377+0.0121147240.9878853
ENST00000394295ENST00000242783ANXA4chr270008706+PKN1chr1914578377+0.0121147240.9878853
ENST00000409920ENST00000242783ANXA4chr270008706+PKN1chr1914578376+0.0121147240.9878853
ENST00000394295ENST00000242783ANXA4chr270008706+PKN1chr1914578376+0.0121147240.9878853

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Fusion Genomic Features for ANXA4-PKN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANXA4chr270008706+PKN1chr1914578376+1.92E-091
ANXA4chr270008706+PKN1chr1914578376+1.92E-091
ANXA4chr270008706+PKN1chr1914578376+1.92E-091
ANXA4chr270008706+PKN1chr1914578376+1.92E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANXA4-PKN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:70008706/chr19:14578377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANXA4

P09525

.
FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePKN1chr2:70008706chr19:14578376ENST000002427831122615_874577943.0DomainProtein kinase
TgenePKN1chr2:70008706chr19:14578376ENST000002427831122875_942577943.0DomainAGC-kinase C-terminal
TgenePKN1chr2:70008706chr19:14578376ENST000003422161122615_874583949.0DomainProtein kinase
TgenePKN1chr2:70008706chr19:14578376ENST000003422161122875_942583949.0DomainAGC-kinase C-terminal
TgenePKN1chr2:70008706chr19:14578377ENST000002427831122615_874577943.0DomainProtein kinase
TgenePKN1chr2:70008706chr19:14578377ENST000002427831122875_942577943.0DomainAGC-kinase C-terminal
TgenePKN1chr2:70008706chr19:14578377ENST000003422161122615_874583949.0DomainProtein kinase
TgenePKN1chr2:70008706chr19:14578377ENST000003422161122875_942583949.0DomainAGC-kinase C-terminal
TgenePKN1chr2:70008706chr19:14578376ENST000002427831122621_629577943.0Nucleotide bindingATP
TgenePKN1chr2:70008706chr19:14578376ENST000003422161122621_629583949.0Nucleotide bindingATP
TgenePKN1chr2:70008706chr19:14578377ENST000002427831122621_629577943.0Nucleotide bindingATP
TgenePKN1chr2:70008706chr19:14578377ENST000003422161122621_629583949.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANXA4chr2:70008706chr19:14578376ENST00000394295+21314_853322.0RepeatAnnexin 1
HgeneANXA4chr2:70008706chr19:14578376ENST00000394295+213169_2413322.0RepeatAnnexin 3
HgeneANXA4chr2:70008706chr19:14578376ENST00000394295+213245_3163322.0RepeatAnnexin 4
HgeneANXA4chr2:70008706chr19:14578376ENST00000394295+21386_1573322.0RepeatAnnexin 2
HgeneANXA4chr2:70008706chr19:14578377ENST00000394295+21314_853322.0RepeatAnnexin 1
HgeneANXA4chr2:70008706chr19:14578377ENST00000394295+213169_2413322.0RepeatAnnexin 3
HgeneANXA4chr2:70008706chr19:14578377ENST00000394295+213245_3163322.0RepeatAnnexin 4
HgeneANXA4chr2:70008706chr19:14578377ENST00000394295+21386_1573322.0RepeatAnnexin 2
TgenePKN1chr2:70008706chr19:14578376ENST000002427831122112_193577943.0DomainREM-1 2
TgenePKN1chr2:70008706chr19:14578376ENST000002427831122201_280577943.0DomainREM-1 3
TgenePKN1chr2:70008706chr19:14578376ENST00000242783112225_100577943.0DomainREM-1 1
TgenePKN1chr2:70008706chr19:14578376ENST000002427831122307_470577943.0DomainC2
TgenePKN1chr2:70008706chr19:14578376ENST000003422161122112_193583949.0DomainREM-1 2
TgenePKN1chr2:70008706chr19:14578376ENST000003422161122201_280583949.0DomainREM-1 3
TgenePKN1chr2:70008706chr19:14578376ENST00000342216112225_100583949.0DomainREM-1 1
TgenePKN1chr2:70008706chr19:14578376ENST000003422161122307_470583949.0DomainC2
TgenePKN1chr2:70008706chr19:14578377ENST000002427831122112_193577943.0DomainREM-1 2
TgenePKN1chr2:70008706chr19:14578377ENST000002427831122201_280577943.0DomainREM-1 3
TgenePKN1chr2:70008706chr19:14578377ENST00000242783112225_100577943.0DomainREM-1 1
TgenePKN1chr2:70008706chr19:14578377ENST000002427831122307_470577943.0DomainC2
TgenePKN1chr2:70008706chr19:14578377ENST000003422161122112_193583949.0DomainREM-1 2
TgenePKN1chr2:70008706chr19:14578377ENST000003422161122201_280583949.0DomainREM-1 3
TgenePKN1chr2:70008706chr19:14578377ENST00000342216112225_100583949.0DomainREM-1 1
TgenePKN1chr2:70008706chr19:14578377ENST000003422161122307_470583949.0DomainC2


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Fusion Gene Sequence for ANXA4-PKN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5064_5064_1_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000394295_PKN1_chr19_14578376_ENST00000242783_length(transcript)=1430nt_BP=257nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGAGCTCCCCCATCC
AGGAATCCACTGCTCCCGAGCTGCCTTCGGAGACCCAGGAGACCCCAGGCCCCGCCCTGTGCAGCCCTCTGAGGAAGTCACCTCTGACCC
TCGAAGATTTCAAGTTCCTGGCGGTGCTGGGCCGGGGTCATTTTGGGAAGGTGCTCCTCTCCGAATTCCGGCCCAGTGGGGAGCTGTTCG
CCATCAAGGCTCTGAAGAAAGGGGACATTGTGGCCCGAGACGAGGTGGAGAGCCTGATGTGTGAGAAGCGGATATTGGCGGCAGTGACCA
GTGCGGGACACCCCTTCCTGGTGAACCTCTTCGGCTGTTTCCAGACACCGGAGCACGTGTGCTTCGTGATGGAGTACTCGGCCGGTGGGG
ACCTGATGCTGCACATCCACAGCGACGTGTTCTCTGAGCCCCGTGCCATCTTTTATTCCGCCTGCGTGGTGCTGGGCCTACAGTTTCTTC
ACGAACACAAGATCGTCTACAGGGACCTGAAGTTGGACAATTTGCTCCTGGACACCGAGGGCTACGTCAAGATCGCAGACTTTGGCCTCT
GCAAGGAGGGGATGGGCTATGGGGACCGGACCAGCACATTCTGTGGGACCCCGGAGTTCCTGGCCCCTGAGGTGCTGACGGACACGTCGT
ACACGCGAGCTGTGGACTGGTGGGGACTGGGTGTGCTGCTCTACGAGATGCTGGTTGGCGAGTCCCCATTCCCAGGGGATGATGAGGAGG
AGGTCTTCGACAGCATCGTCAACGACGAGGTTCGCTACCCCCGCTTCCTGTCGGCCGAAGCCATCGGCATCATGAGAAGGCTGCTTCGGA
GGAACCCAGAGCGGAGGCTGGGATCTAGCGAGAGAGATGCAGAAGATGTGAAGAAACAGCCCTTCTTCAGGACTCTGGGCTGGGAAGCCC
TGTTGGCCCGGCGCCTGCCACCGCCCTTTGTGCCCACGCTGTCCGGCCGCACCGACGTCAGCAACTTCGACGAGGAGTTCACCGGGGAGG
CCCCCACACTGAGCCCGCCCCGCGACGCGCGGCCCCTCACAGCCGCGGAGCAGGCAGCCTTCCTGGACTTCGACTTCGTGGCCGGGGGCT

>5064_5064_1_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000394295_PKN1_chr19_14578376_ENST00000242783_length(amino acids)=368AA_BP=3
MAMSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK
RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV
KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG
IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLD

--------------------------------------------------------------
>5064_5064_2_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000394295_PKN1_chr19_14578377_ENST00000242783_length(transcript)=1430nt_BP=257nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGAGCTCCCCCATCC
AGGAATCCACTGCTCCCGAGCTGCCTTCGGAGACCCAGGAGACCCCAGGCCCCGCCCTGTGCAGCCCTCTGAGGAAGTCACCTCTGACCC
TCGAAGATTTCAAGTTCCTGGCGGTGCTGGGCCGGGGTCATTTTGGGAAGGTGCTCCTCTCCGAATTCCGGCCCAGTGGGGAGCTGTTCG
CCATCAAGGCTCTGAAGAAAGGGGACATTGTGGCCCGAGACGAGGTGGAGAGCCTGATGTGTGAGAAGCGGATATTGGCGGCAGTGACCA
GTGCGGGACACCCCTTCCTGGTGAACCTCTTCGGCTGTTTCCAGACACCGGAGCACGTGTGCTTCGTGATGGAGTACTCGGCCGGTGGGG
ACCTGATGCTGCACATCCACAGCGACGTGTTCTCTGAGCCCCGTGCCATCTTTTATTCCGCCTGCGTGGTGCTGGGCCTACAGTTTCTTC
ACGAACACAAGATCGTCTACAGGGACCTGAAGTTGGACAATTTGCTCCTGGACACCGAGGGCTACGTCAAGATCGCAGACTTTGGCCTCT
GCAAGGAGGGGATGGGCTATGGGGACCGGACCAGCACATTCTGTGGGACCCCGGAGTTCCTGGCCCCTGAGGTGCTGACGGACACGTCGT
ACACGCGAGCTGTGGACTGGTGGGGACTGGGTGTGCTGCTCTACGAGATGCTGGTTGGCGAGTCCCCATTCCCAGGGGATGATGAGGAGG
AGGTCTTCGACAGCATCGTCAACGACGAGGTTCGCTACCCCCGCTTCCTGTCGGCCGAAGCCATCGGCATCATGAGAAGGCTGCTTCGGA
GGAACCCAGAGCGGAGGCTGGGATCTAGCGAGAGAGATGCAGAAGATGTGAAGAAACAGCCCTTCTTCAGGACTCTGGGCTGGGAAGCCC
TGTTGGCCCGGCGCCTGCCACCGCCCTTTGTGCCCACGCTGTCCGGCCGCACCGACGTCAGCAACTTCGACGAGGAGTTCACCGGGGAGG
CCCCCACACTGAGCCCGCCCCGCGACGCGCGGCCCCTCACAGCCGCGGAGCAGGCAGCCTTCCTGGACTTCGACTTCGTGGCCGGGGGCT

>5064_5064_2_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000394295_PKN1_chr19_14578377_ENST00000242783_length(amino acids)=368AA_BP=3
MAMSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK
RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV
KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG
IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLD

--------------------------------------------------------------
>5064_5064_3_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000409920_PKN1_chr19_14578376_ENST00000242783_length(transcript)=1430nt_BP=257nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGAGCTCCCCCATCC
AGGAATCCACTGCTCCCGAGCTGCCTTCGGAGACCCAGGAGACCCCAGGCCCCGCCCTGTGCAGCCCTCTGAGGAAGTCACCTCTGACCC
TCGAAGATTTCAAGTTCCTGGCGGTGCTGGGCCGGGGTCATTTTGGGAAGGTGCTCCTCTCCGAATTCCGGCCCAGTGGGGAGCTGTTCG
CCATCAAGGCTCTGAAGAAAGGGGACATTGTGGCCCGAGACGAGGTGGAGAGCCTGATGTGTGAGAAGCGGATATTGGCGGCAGTGACCA
GTGCGGGACACCCCTTCCTGGTGAACCTCTTCGGCTGTTTCCAGACACCGGAGCACGTGTGCTTCGTGATGGAGTACTCGGCCGGTGGGG
ACCTGATGCTGCACATCCACAGCGACGTGTTCTCTGAGCCCCGTGCCATCTTTTATTCCGCCTGCGTGGTGCTGGGCCTACAGTTTCTTC
ACGAACACAAGATCGTCTACAGGGACCTGAAGTTGGACAATTTGCTCCTGGACACCGAGGGCTACGTCAAGATCGCAGACTTTGGCCTCT
GCAAGGAGGGGATGGGCTATGGGGACCGGACCAGCACATTCTGTGGGACCCCGGAGTTCCTGGCCCCTGAGGTGCTGACGGACACGTCGT
ACACGCGAGCTGTGGACTGGTGGGGACTGGGTGTGCTGCTCTACGAGATGCTGGTTGGCGAGTCCCCATTCCCAGGGGATGATGAGGAGG
AGGTCTTCGACAGCATCGTCAACGACGAGGTTCGCTACCCCCGCTTCCTGTCGGCCGAAGCCATCGGCATCATGAGAAGGCTGCTTCGGA
GGAACCCAGAGCGGAGGCTGGGATCTAGCGAGAGAGATGCAGAAGATGTGAAGAAACAGCCCTTCTTCAGGACTCTGGGCTGGGAAGCCC
TGTTGGCCCGGCGCCTGCCACCGCCCTTTGTGCCCACGCTGTCCGGCCGCACCGACGTCAGCAACTTCGACGAGGAGTTCACCGGGGAGG
CCCCCACACTGAGCCCGCCCCGCGACGCGCGGCCCCTCACAGCCGCGGAGCAGGCAGCCTTCCTGGACTTCGACTTCGTGGCCGGGGGCT

>5064_5064_3_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000409920_PKN1_chr19_14578376_ENST00000242783_length(amino acids)=368AA_BP=3
MAMSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK
RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV
KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG
IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLD

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>5064_5064_4_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000409920_PKN1_chr19_14578377_ENST00000242783_length(transcript)=1430nt_BP=257nt
GCGCGGCCGTCCCGGCCCGGGGCCCCAGGTGCGCTTCCCCTAGAGAGGGATTTTCCGGTCTCGTGGGCAGAGGAACAACCAGGAACTTGG
GCTCAGTCTCCACCCCACAGTGGGGCGGATCCGTCCCGGATAAGACCCGCTGTCTGGCCCTGAGTAGGGTGTGACCTCCGCAGCCGCAGA
GGAGGAGCGCAGCCCGGCCTCGAAGAACTTCTGCTTGGGTGGCTGAACTCTGATCTTGACCTAGAGTCATGGCCATGAGCTCCCCCATCC
AGGAATCCACTGCTCCCGAGCTGCCTTCGGAGACCCAGGAGACCCCAGGCCCCGCCCTGTGCAGCCCTCTGAGGAAGTCACCTCTGACCC
TCGAAGATTTCAAGTTCCTGGCGGTGCTGGGCCGGGGTCATTTTGGGAAGGTGCTCCTCTCCGAATTCCGGCCCAGTGGGGAGCTGTTCG
CCATCAAGGCTCTGAAGAAAGGGGACATTGTGGCCCGAGACGAGGTGGAGAGCCTGATGTGTGAGAAGCGGATATTGGCGGCAGTGACCA
GTGCGGGACACCCCTTCCTGGTGAACCTCTTCGGCTGTTTCCAGACACCGGAGCACGTGTGCTTCGTGATGGAGTACTCGGCCGGTGGGG
ACCTGATGCTGCACATCCACAGCGACGTGTTCTCTGAGCCCCGTGCCATCTTTTATTCCGCCTGCGTGGTGCTGGGCCTACAGTTTCTTC
ACGAACACAAGATCGTCTACAGGGACCTGAAGTTGGACAATTTGCTCCTGGACACCGAGGGCTACGTCAAGATCGCAGACTTTGGCCTCT
GCAAGGAGGGGATGGGCTATGGGGACCGGACCAGCACATTCTGTGGGACCCCGGAGTTCCTGGCCCCTGAGGTGCTGACGGACACGTCGT
ACACGCGAGCTGTGGACTGGTGGGGACTGGGTGTGCTGCTCTACGAGATGCTGGTTGGCGAGTCCCCATTCCCAGGGGATGATGAGGAGG
AGGTCTTCGACAGCATCGTCAACGACGAGGTTCGCTACCCCCGCTTCCTGTCGGCCGAAGCCATCGGCATCATGAGAAGGCTGCTTCGGA
GGAACCCAGAGCGGAGGCTGGGATCTAGCGAGAGAGATGCAGAAGATGTGAAGAAACAGCCCTTCTTCAGGACTCTGGGCTGGGAAGCCC
TGTTGGCCCGGCGCCTGCCACCGCCCTTTGTGCCCACGCTGTCCGGCCGCACCGACGTCAGCAACTTCGACGAGGAGTTCACCGGGGAGG
CCCCCACACTGAGCCCGCCCCGCGACGCGCGGCCCCTCACAGCCGCGGAGCAGGCAGCCTTCCTGGACTTCGACTTCGTGGCCGGGGGCT

>5064_5064_4_ANXA4-PKN1_ANXA4_chr2_70008706_ENST00000409920_PKN1_chr19_14578377_ENST00000242783_length(amino acids)=368AA_BP=3
MAMSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK
RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV
KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG
IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLD

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Fusion Gene PPI Analysis for ANXA4-PKN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANXA4-PKN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANXA4-PKN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource