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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MACROD1-TBC1D22A (FusionGDB2 ID:50648)

Fusion Gene Summary for MACROD1-TBC1D22A

check button Fusion gene summary
Fusion gene informationFusion gene name: MACROD1-TBC1D22A
Fusion gene ID: 50648
HgeneTgene
Gene symbol

MACROD1

TBC1D22A

Gene ID

28992

25771

Gene namemono-ADP ribosylhydrolase 1TBC1 domain family member 22A
SynonymsLRP16C22orf4|HSC79E021
Cytomap

11q13.1

22q13.31

Type of geneprotein-codingprotein-coding
DescriptionADP-ribose glycohydrolase MACROD1MACRO domain containing 1MACRO domain-containing protein 1O-acetyl-ADP-ribose deacetylase MACROD1[Protein ADP-ribosylaspartate] hydrolase MACROD1[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate] TBC1 domain family member 22Aputative GTPase activator
Modification date2020031320200313
UniProtAcc

Q9BQ69

.
Ensembl transtripts involved in fusion geneENST00000255681, ENST00000538595, 
ENST00000406733, ENST00000472791, 
ENST00000337137, ENST00000355704, 
ENST00000380995, ENST00000407381, 
Fusion gene scores* DoF score16 X 7 X 13=145622 X 24 X 11=5808
# samples 2232
** MAII scorelog2(22/1456*10)=-2.72643492667404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/5808*10)=-4.18189764310839
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MACROD1 [Title/Abstract] AND TBC1D22A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMACROD1(63918711)-TBC1D22A(47274549), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACROD1

GO:0042278

purine nucleoside metabolic process

21257746

HgeneMACROD1

GO:0051725

protein de-ADP-ribosylation

23474712


check buttonFusion gene breakpoints across MACROD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBC1D22A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2104-01AMACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
ChimerDB4OVTCGA-61-2104MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+


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Fusion Gene ORF analysis for MACROD1-TBC1D22A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000255681ENST00000406733MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5CDS-intronENST00000255681ENST00000406733MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
5CDS-intronENST00000255681ENST00000472791MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5CDS-intronENST00000255681ENST00000472791MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
5UTR-3CDSENST00000538595ENST00000337137MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000337137MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
5UTR-3CDSENST00000538595ENST00000355704MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000355704MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
5UTR-3CDSENST00000538595ENST00000380995MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000380995MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
5UTR-3CDSENST00000538595ENST00000407381MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000407381MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
5UTR-intronENST00000538595ENST00000406733MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-intronENST00000538595ENST00000406733MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
5UTR-intronENST00000538595ENST00000472791MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-intronENST00000538595ENST00000472791MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
In-frameENST00000255681ENST00000337137MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
In-frameENST00000255681ENST00000337137MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
In-frameENST00000255681ENST00000355704MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
In-frameENST00000255681ENST00000355704MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
In-frameENST00000255681ENST00000380995MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
In-frameENST00000255681ENST00000380995MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+
In-frameENST00000255681ENST00000407381MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
In-frameENST00000255681ENST00000407381MACROD1chr11

63918710

-TBC1D22Achr22

47274548

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000255681MACROD1chr1163918711-ENST00000337137TBC1D22Achr2247274549+3568584671500477
ENST00000255681MACROD1chr1163918711-ENST00000380995TBC1D22Achr2247274549+1063584671062332
ENST00000255681MACROD1chr1163918711-ENST00000407381TBC1D22Achr2247274549+1958584671500477
ENST00000255681MACROD1chr1163918711-ENST00000355704TBC1D22Achr2247274549+1961584671500477
ENST00000255681MACROD1chr1163918710-ENST00000337137TBC1D22Achr2247274548+3568584671500477
ENST00000255681MACROD1chr1163918710-ENST00000380995TBC1D22Achr2247274548+1063584671062332
ENST00000255681MACROD1chr1163918710-ENST00000407381TBC1D22Achr2247274548+1958584671500477
ENST00000255681MACROD1chr1163918710-ENST00000355704TBC1D22Achr2247274548+1961584671500477

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000255681ENST00000337137MACROD1chr1163918711-TBC1D22Achr2247274549+0.0028628330.9971372
ENST00000255681ENST00000380995MACROD1chr1163918711-TBC1D22Achr2247274549+0.0126193920.9873806
ENST00000255681ENST00000407381MACROD1chr1163918711-TBC1D22Achr2247274549+0.0058214390.99417853
ENST00000255681ENST00000355704MACROD1chr1163918711-TBC1D22Achr2247274549+0.0058323390.9941677
ENST00000255681ENST00000337137MACROD1chr1163918710-TBC1D22Achr2247274548+0.0028628330.9971372
ENST00000255681ENST00000380995MACROD1chr1163918710-TBC1D22Achr2247274548+0.0126193920.9873806
ENST00000255681ENST00000407381MACROD1chr1163918710-TBC1D22Achr2247274548+0.0058214390.99417853
ENST00000255681ENST00000355704MACROD1chr1163918710-TBC1D22Achr2247274548+0.0058323390.9941677

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Fusion Genomic Features for MACROD1-TBC1D22A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MACROD1-TBC1D22A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:63918711/chr22:47274549)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MACROD1

Q9BQ69

.
FUNCTION: Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104). {ECO:0000269|PubMed:17893710, ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACROD1chr11:63918710chr22:47274548ENST00000255681-311159_161172225.33333333333334RegionSubstrate binding
HgeneMACROD1chr11:63918710chr22:47274548ENST00000255681-311172_174172225.33333333333334RegionSubstrate binding
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311159_161172225.33333333333334RegionSubstrate binding
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311172_174172225.33333333333334RegionSubstrate binding
TgeneTBC1D22Achr11:63918710chr22:47274548ENST00000337137313222_446212518.0DomainRab-GAP TBC
TgeneTBC1D22Achr11:63918710chr22:47274548ENST00000355704111222_446134440.0DomainRab-GAP TBC
TgeneTBC1D22Achr11:63918710chr22:47274548ENST0000038099539222_446165325.0DomainRab-GAP TBC
TgeneTBC1D22Achr11:63918711chr22:47274549ENST00000337137313222_446212518.0DomainRab-GAP TBC
TgeneTBC1D22Achr11:63918711chr22:47274549ENST00000355704111222_446134440.0DomainRab-GAP TBC
TgeneTBC1D22Achr11:63918711chr22:47274549ENST0000038099539222_446165325.0DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACROD1chr11:63918710chr22:47274548ENST00000255681-311141_322172225.33333333333334DomainMacro
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311141_322172225.33333333333334DomainMacro
HgeneMACROD1chr11:63918710chr22:47274548ENST00000255681-311179_184172225.33333333333334RegionSubstrate binding
HgeneMACROD1chr11:63918710chr22:47274548ENST00000255681-311267_273172225.33333333333334RegionSubstrate binding
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311179_184172225.33333333333334RegionSubstrate binding
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311267_273172225.33333333333334RegionSubstrate binding


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Fusion Gene Sequence for MACROD1-TBC1D22A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50648_50648_1_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000337137_length(transcript)=3568nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC
CATCTCATACCTACTCTGAAATGCAAAACTTCTATTCTGTTGAGTGAAAGAATAAAATGTAGACAAAATCTAGACCGAGACGTTGCGCTG
ACCCGGGGTCTCTGTGCCGCGAGGTCCCCTCACAGCTGTATTTCACTGCTGCTGGCCCTTTCCCTCCGTGTGTTTTCCTGCTTGCTTGGT
TTAAACGTGGCTGGGAAGCTGAAGGCTGGAGTCCAAGCCGTGAGCCCGCCGAGTGCCTGGGAGGCCGTGGGACCAAAGGCTGGGAGCAGA
GGGAGGCCTCGCCATCGCCTTACTTTCCACCTTGAACCTCTTTTACAAGAGAGAAACCCCCACCTCCCTGAGGTCCAGGGCCAAGTGGCC
CCGCCACGCAGGTAGGCGCCGGCCTCAGCCAGAGCCCCTGGAGGCCCACCCAGGCTGTCGGGCCATGTTGGGCTGGCAGACGGGCAGGGG
GTCGCGTCCCTGTCATCAAAGCCCTGAACCACAGTGCTCTTCTCACCGCAGCCTGGAAGCGGAATGAGCTTTTGGAGACTTCCTGGGACT
TGCTGTCCTTGTCCAGGTCTGCCAGGTGTAGGGGAGGTGTGACTGGTTCCATCATGGACCGGTTCCTCCATGGACCGGTTCCTCCGTGGA
CCGGTTCCGCCATGGACCGGTTCCGCCATGGACCACTCCTGCCCTGGACCACTCCTGCCCTGGACCGGTTCTGCCGTGGACTGGTTCCCG
CCGTGGACCAGTTCCCGCTGTATACTGGTTCTGCCCTGGACTGGTTCCCGCTGTGGACTGGTTCCTTGGGGCTCTAAGTGCGGAAGGGCC
CAGAGCTGGTCCCTGCCCAGCGCCCTGCTAGGGCTGTGTCCTTGGCTCCAGGGGCCTTGGGACTGGCTTCCCAGCGTTCCCTCGGTGTGT
CACAGGCTGCATGACCCCTGGAATGCGGGCAGGGCCACAGCCACAGTCTGTCTGATCCCTGAGCCCAGGACAGGCTCACGTCCTCAGCGA
CCCACTGGTGACTGACTTCCCAGACTCTCCTCTGTCCCTCAGGAGCAGCCGTGTCCTCTCCCAGGCCCTAGGACACTGCCAGAGACTGTG
GGACATACAGGCATAAGTGATGTGTGTGTTTCTGCTTCTGTTTTAAAAATCCAGGGTCATTACACACAGCATGGAAATTAGCACAAAATG
CTGTGCAAACGTCAGATGCTCCCAAACCAGCAAAGGGATGGGCTTGCTTCACATCAGATGCGGGCACGCCTTACCCCTGCCTTCCGTGTC
CCCACCCCAGGGTCAAGGGTTCCTCAGACCAGCCATGCCTCCTCCTCCTGCCGCCTCCTTTTCTAGATGGGGAGGGGATTCCGTCACAAG
AAGAGCCGCCCCTCGGCCGTGTGCAGGAAGCCCCATGTCGCTTTGCCGAGATCAGCCCTGGGAGGATCCCCTTCTCCAGCTCAGATCATG
CCGTGTGGCCAGAAGGCTGCGGACACAACTGACCTGCTTCTCGAGGTGGTTGATGTTTTAAACAGGAAGCTCCACGGAGTTCAGCCCTGT
GTGCATTTCCTCATGTATGTAAACGCCAAGACTGAATGTGAGAGGTGTTGGCCGCGGGCCTTAAGTCTGAGCAGATCCATCTGGAATGTT

>50648_50648_1_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000337137_length(amino acids)=477AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

--------------------------------------------------------------
>50648_50648_2_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000355704_length(transcript)=1961nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC

>50648_50648_2_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000355704_length(amino acids)=477AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

--------------------------------------------------------------
>50648_50648_3_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000380995_length(transcript)=1063nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGCCTTTCCAGGTTGTGGTCGGCCTCAGAT

>50648_50648_3_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000380995_length(amino acids)=332AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA

--------------------------------------------------------------
>50648_50648_4_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000407381_length(transcript)=1958nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC

>50648_50648_4_MACROD1-TBC1D22A_MACROD1_chr11_63918710_ENST00000255681_TBC1D22A_chr22_47274548_ENST00000407381_length(amino acids)=477AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

--------------------------------------------------------------
>50648_50648_5_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000337137_length(transcript)=3568nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC
CATCTCATACCTACTCTGAAATGCAAAACTTCTATTCTGTTGAGTGAAAGAATAAAATGTAGACAAAATCTAGACCGAGACGTTGCGCTG
ACCCGGGGTCTCTGTGCCGCGAGGTCCCCTCACAGCTGTATTTCACTGCTGCTGGCCCTTTCCCTCCGTGTGTTTTCCTGCTTGCTTGGT
TTAAACGTGGCTGGGAAGCTGAAGGCTGGAGTCCAAGCCGTGAGCCCGCCGAGTGCCTGGGAGGCCGTGGGACCAAAGGCTGGGAGCAGA
GGGAGGCCTCGCCATCGCCTTACTTTCCACCTTGAACCTCTTTTACAAGAGAGAAACCCCCACCTCCCTGAGGTCCAGGGCCAAGTGGCC
CCGCCACGCAGGTAGGCGCCGGCCTCAGCCAGAGCCCCTGGAGGCCCACCCAGGCTGTCGGGCCATGTTGGGCTGGCAGACGGGCAGGGG
GTCGCGTCCCTGTCATCAAAGCCCTGAACCACAGTGCTCTTCTCACCGCAGCCTGGAAGCGGAATGAGCTTTTGGAGACTTCCTGGGACT
TGCTGTCCTTGTCCAGGTCTGCCAGGTGTAGGGGAGGTGTGACTGGTTCCATCATGGACCGGTTCCTCCATGGACCGGTTCCTCCGTGGA
CCGGTTCCGCCATGGACCGGTTCCGCCATGGACCACTCCTGCCCTGGACCACTCCTGCCCTGGACCGGTTCTGCCGTGGACTGGTTCCCG
CCGTGGACCAGTTCCCGCTGTATACTGGTTCTGCCCTGGACTGGTTCCCGCTGTGGACTGGTTCCTTGGGGCTCTAAGTGCGGAAGGGCC
CAGAGCTGGTCCCTGCCCAGCGCCCTGCTAGGGCTGTGTCCTTGGCTCCAGGGGCCTTGGGACTGGCTTCCCAGCGTTCCCTCGGTGTGT
CACAGGCTGCATGACCCCTGGAATGCGGGCAGGGCCACAGCCACAGTCTGTCTGATCCCTGAGCCCAGGACAGGCTCACGTCCTCAGCGA
CCCACTGGTGACTGACTTCCCAGACTCTCCTCTGTCCCTCAGGAGCAGCCGTGTCCTCTCCCAGGCCCTAGGACACTGCCAGAGACTGTG
GGACATACAGGCATAAGTGATGTGTGTGTTTCTGCTTCTGTTTTAAAAATCCAGGGTCATTACACACAGCATGGAAATTAGCACAAAATG
CTGTGCAAACGTCAGATGCTCCCAAACCAGCAAAGGGATGGGCTTGCTTCACATCAGATGCGGGCACGCCTTACCCCTGCCTTCCGTGTC
CCCACCCCAGGGTCAAGGGTTCCTCAGACCAGCCATGCCTCCTCCTCCTGCCGCCTCCTTTTCTAGATGGGGAGGGGATTCCGTCACAAG
AAGAGCCGCCCCTCGGCCGTGTGCAGGAAGCCCCATGTCGCTTTGCCGAGATCAGCCCTGGGAGGATCCCCTTCTCCAGCTCAGATCATG
CCGTGTGGCCAGAAGGCTGCGGACACAACTGACCTGCTTCTCGAGGTGGTTGATGTTTTAAACAGGAAGCTCCACGGAGTTCAGCCCTGT
GTGCATTTCCTCATGTATGTAAACGCCAAGACTGAATGTGAGAGGTGTTGGCCGCGGGCCTTAAGTCTGAGCAGATCCATCTGGAATGTT

>50648_50648_5_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000337137_length(amino acids)=477AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

--------------------------------------------------------------
>50648_50648_6_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000355704_length(transcript)=1961nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC

>50648_50648_6_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000355704_length(amino acids)=477AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

--------------------------------------------------------------
>50648_50648_7_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000380995_length(transcript)=1063nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGCCTTTCCAGGTTGTGGTCGGCCTCAGAT

>50648_50648_7_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000380995_length(amino acids)=332AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA

--------------------------------------------------------------
>50648_50648_8_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000407381_length(transcript)=1958nt_BP=584nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC

>50648_50648_8_MACROD1-TBC1D22A_MACROD1_chr11_63918711_ENST00000255681_TBC1D22A_chr22_47274549_ENST00000407381_length(amino acids)=477AA_BP=172
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

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Fusion Gene PPI Analysis for MACROD1-TBC1D22A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MACROD1-TBC1D22A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MACROD1-TBC1D22A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource