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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:MACROD2-SPTLC3 (FusionGDB2 ID:50669)

Fusion Gene Summary for MACROD2-SPTLC3

Fusion gene summary

Fusion gene information	Fusion gene name: MACROD2-SPTLC3
	Fusion gene ID: 50669
		Hgene	Tgene
	Gene symbol	MACROD2	SPTLC3
	Gene ID	140733	55304
	Gene name	mono-ADP ribosylhydrolase 2	serine palmitoyltransferase long chain base subunit 3
	Synonyms	C20orf133\|C2orf133	C20orf38\|LCB 3\|LCB2B\|LCB3\|SPT 3\|SPT3\|SPTLC2L\|dJ718P11\|dJ718P11.1\|hLCB2b
	Cytomap	20p12.1	20p12.1
	Type of gene	protein-coding	protein-coding
	Description	ADP-ribose glycohydrolase MACROD2MACRO domain containing 2MACRO domain-containing protein 2O-acetyl-ADP-ribose deacetylase MACROD2[Protein ADP-ribosylaspartate] hydrolase MACROD2[Protein ADP-ribosylglutamate] hydrolase[Protein ADP-ribosylglutamate]	serine palmitoyltransferase 3long chain base biosynthesis protein 2blong chain base biosynthesis protein 3serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)serine-palmitoyl-CoA transferase 3
	Modification date	20200313	20200313
	UniProtAcc	A1Z1Q3	.
	Ensembl transtripts involved in fusion gene	ENST00000217246, ENST00000310348, ENST00000378058, ENST00000402914, ENST00000407045, ENST00000464883,	ENST00000476791, ENST00000378194, ENST00000399002,
Fusion gene scores	* DoF score	22 X 20 X 10=4400	1 X 2 X 2=4
	# samples	25	2
	** MAII score	log2(25/4400*10)=-4.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: MACROD2 [Title/Abstract] AND SPTLC3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MACROD2(14066374)-SPTLC3(13090759), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MACROD2	GO:0042278	purine nucleoside metabolic process	21257746
Hgene	MACROD2	GO:0051725	protein de-ADP-ribosylation	23474712
Tgene	SPTLC3	GO:0046520	sphingoid biosynthetic process	19648650

Fusion gene breakpoints across MACROD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPTLC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-QT-A5XJ-01A	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
ChimerDB4	SKCM	TCGA-EE-A29D-06A	MACROD2	chr20	14066374	-	SPTLC3	chr20	13090759	+
ChimerDB4	SKCM	TCGA-EE-A29D-06A	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+

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Fusion Gene ORF analysis for MACROD2-SPTLC3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000217246	ENST00000476791	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
5CDS-intron	ENST00000217246	ENST00000476791	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
5CDS-intron	ENST00000310348	ENST00000476791	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
5CDS-intron	ENST00000310348	ENST00000476791	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
In-frame	ENST00000217246	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
In-frame	ENST00000217246	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
In-frame	ENST00000217246	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
In-frame	ENST00000217246	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
In-frame	ENST00000310348	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
In-frame	ENST00000310348	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
In-frame	ENST00000310348	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
In-frame	ENST00000310348	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000378058	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000378058	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000378058	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000378058	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000402914	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000402914	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000402914	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000402914	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000407045	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000407045	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000407045	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000407045	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000464883	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000464883	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-3CDS	ENST00000464883	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-3CDS	ENST00000464883	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-intron	ENST00000378058	ENST00000476791	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-intron	ENST00000378058	ENST00000476791	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-intron	ENST00000402914	ENST00000476791	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-intron	ENST00000402914	ENST00000476791	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-intron	ENST00000407045	ENST00000476791	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-intron	ENST00000407045	ENST00000476791	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+
intron-intron	ENST00000464883	ENST00000476791	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+
intron-intron	ENST00000464883	ENST00000476791	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000217246	MACROD2	chr20	14066374	+	ENST00000399002	SPTLC3	chr20	13090759	+	3396	666	341	1498	385
ENST00000217246	MACROD2	chr20	14066374	+	ENST00000378194	SPTLC3	chr20	13090759	+	1361	666	733	1233	166
ENST00000310348	MACROD2	chr20	14066374	+	ENST00000399002	SPTLC3	chr20	13090759	+	3001	271	0	1103	367
ENST00000310348	MACROD2	chr20	14066374	+	ENST00000378194	SPTLC3	chr20	13090759	+	966	271	338	838	166
ENST00000217246	MACROD2	chr20	14474154	-	ENST00000399002	SPTLC3	chr20	13071731	+	3645	696	341	1747	468
ENST00000217246	MACROD2	chr20	14474154	-	ENST00000378194	SPTLC3	chr20	13071731	+	1610	696	341	1078	245
ENST00000310348	MACROD2	chr20	14474154	-	ENST00000399002	SPTLC3	chr20	13071731	+	3250	301	0	1352	450
ENST00000310348	MACROD2	chr20	14474154	-	ENST00000378194	SPTLC3	chr20	13071731	+	1215	301	0	683	227

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000217246	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+	0.000627034	0.999373
ENST00000217246	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+	0.015354791	0.9846452
ENST00000310348	ENST00000399002	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+	0.000415259	0.99958473
ENST00000310348	ENST00000378194	MACROD2	chr20	14066374	+	SPTLC3	chr20	13090759	+	0.010395538	0.9896045
ENST00000217246	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+	0.000969061	0.99903095
ENST00000217246	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+	0.006601544	0.9933984
ENST00000310348	ENST00000399002	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+	0.000652974	0.99934703
ENST00000310348	ENST00000378194	MACROD2	chr20	14474154	-	SPTLC3	chr20	13071731	+	0.003197805	0.9968022

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Fusion Genomic Features for MACROD2-SPTLC3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MACROD2-SPTLC3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:14066374/chr20:13090759)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MACROD2 A1Z1Q3	.
FUNCTION: Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269\|PubMed:21257746, ECO:0000269\|PubMed:23474712, ECO:0000269\|PubMed:23474714}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000217246

6_9

426.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000310348

6_9

449.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000217246

6_9

100

426.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000310348

6_9

100

449.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000217246

77_79

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000217246

90_92

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000310348

77_79

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000310348

90_92

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000217246

77_79

100

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000217246

90_92

100

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000217246

97_102

100

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000310348

77_79

100

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000310348

90_92

100

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000310348

97_102

100

449.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000217246

247_388

426.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000310348

247_388

449.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000378058

247_388

214.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000378058

6_9

214.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000402914

247_388

214.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000402914

6_9

214.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000407045

247_388

99.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000407045

6_9

99.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000217246

247_388

100

426.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000310348

247_388

100

449.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000378058

247_388

214.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000378058

6_9

214.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000402914

247_388

214.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000402914

6_9

214.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000407045

247_388

99.0

Compositional bias

Note=Glu-rich

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000407045

6_9

99.0

Compositional bias

Note=Poly-Lys

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000217246

59_240

426.0

Domain

Macro

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000310348

59_240

449.0

Domain

Macro

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000378058

59_240

214.0

Domain

Macro

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000402914

59_240

214.0

Domain

Macro

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000407045

59_240

99.0

Domain

Macro

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000217246

59_240

100

426.0

Domain

Macro

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000310348

59_240

100

449.0

Domain

Macro

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000378058

59_240

214.0

Domain

Macro

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000402914

59_240

214.0

Domain

Macro

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000407045

59_240

99.0

Domain

Macro

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000217246

185_191

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000217246

97_102

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000310348

185_191

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000310348

97_102

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000378058

185_191

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000378058

77_79

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000378058

90_92

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000378058

97_102

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000402914

185_191

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000402914

77_79

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000402914

90_92

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000402914

97_102

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000407045

185_191

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000407045

77_79

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000407045

90_92

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:14066374

chr20:13090759

ENST00000407045

97_102

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000217246

185_191

100

426.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000310348

185_191

100

449.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000378058

185_191

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000378058

77_79

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000378058

90_92

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000378058

97_102

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000402914

185_191

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000402914

77_79

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000402914

90_92

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000402914

97_102

214.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000407045

185_191

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000407045

77_79

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000407045

90_92

99.0

Region

Substrate binding

Hgene

MACROD2

chr20:14474154

chr20:13071731

ENST00000407045

97_102

99.0

Region

Substrate binding

Tgene

SPTLC3

chr20:14066374

chr20:13090759

ENST00000399002

59_79

275

553.0

Transmembrane

Helical

Tgene

SPTLC3

chr20:14474154

chr20:13071731

ENST00000399002

59_79

202

553.0

Transmembrane

Helical

Top

Fusion Gene Sequence for MACROD2-SPTLC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50669_50669_1_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000217246_SPTLC3_chr20_13090759_ENST00000378194_length(transcript)=1361nt_BP=666nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTC
GAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGC
TGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGG
GCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAA
TGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGT
CGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTGAG
TACACCACAGGCCAACGGGATCTCAGTACCAGTACCTTGGATTCAAAGCAAGTCCTTTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCT
CTTGGGTTATTTAGGAAAACAACACTGACAAAAGTCACTGCCAAAAAACAAGAGCTCGTCAACAACAGCCAACACTGTGACCACTCAGTA

>50669_50669_1_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000217246_SPTLC3_chr20_13090759_ENST00000378194_length(amino acids)=166AA_BP=
MEKDSHPGGGCLQDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVV

--------------------------------------------------------------
>50669_50669_2_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000217246_SPTLC3_chr20_13090759_ENST00000399002_length(transcript)=3396nt_BP=666nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTC
GAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAG
CTCTAAAGAAGAAATACAAGGCTTACCTCTACATAGATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGT
TCTTTGGACTAGACCCTCATGAAGTTGATGTGCTCATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGA
AGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGAT
CACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAA
GACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTT
TTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTG
TTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGC
ACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAGACGAGCTTTGAACTCGAAGATTAAGTTTCCTGGTCCTGAATGACACATAAAGACT
TTGCGAGAAAGACCTCCCTCCTTGCCTCACAAGGAATATAAATGGATTTCTCCCCCTTCCTCAGGACAATTTTGGTTCCCAGACCAGCTT
GATTGAACTGAGGGAGACGTTGTTGTTTTTAATGTCTCCAGCTTGGACTGCAGAGACAAAAACATGATTCCAGATTTAAGTCTCTCTTCT
TCCAAGTATTCTACTAGAAATACACACACACACACACACACACTTCTGAGAATATTTTTAATGGCAATAAGCCTGTGTTTTAGCTGCTAC
TGTGCAGACCCTTTCAGGGATTCCAACCAAATGCAAATGAGAGAATTTAAAATTTTTATTCAGTAAGTTCACTATGTGTTTACTTATTCC
ATCTGCAGATGTAAGTGAGTGTGGTGGACAGTAGCCACCTTCCTTGTTCCACTCATAAAAGCATCAGCTAGATCTCATCTGTATCATGGG
AAGTTCCAGGCAGGAGGGTAAAGAAATGTTGTTTCTACCATTTGTCACATTTGGACGTTTTTCACAGACAAGTGTCAAAAGACATAGTTA
ATGTTTCGAGGGGGAAAGCAGAACTGATCAACTGCGACTAGAGACGTCTTTGAAGGAAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAG
TTTTACAGCTGAGCTTTTGAGGTTTGGAAAATTCAAGATGTTTGTTTCATAAGAAAAGGGGCAGAAAGCAAGCACAAGACACTTTTAGGT
CTAGACTAAAATGGTAGTTACAACAATTTGAACCTTGTTGGTGCAGTGCACGGTGAATGCTTACCCTGCACAGCCTCTATTACCTTAAGG
AATTAGTTGTCATTTTCCTATTGAATTTTGAGTAAATGGTGAAATTCAGTGTCCTTTAGAATCGACTCCCAAGACTATATTTGAAGAATG
CATTGATTCAAGAAGGACATTTAAAAGCAAATTCTGACTTTTTCAAGACCAACACACTTGTTTAGGCCTATTAAATTGTACTATCACTTG
TTACATGCCCTCTGAATTGGGAGAAAGTGGGCTTGCACACTTTGAGGTAACTAACTGTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCC
TTCTCAACATGAACACAAACCTCTATGGAAAAGTAGCCTCTTGTTAATCTGATCTAGTTTGTATGGAAAAAGCCCATGGAGAACCTTATC
TTTAACAAGCTCCCAGAGGGTGCCCAGATTTGGAAATTCTAGAGAGCAGTGGTGACCTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAG
TTGCAGAACATTCCACTCCATCAAATGACACTGTAAACAAATCACTTCAAGAGAGGCTTGGTTTTGTGTGGCACAGATGGACCCAAGCTT
TCATGCTGTGCACTGAGATAGAAACTCCACCCGCAGCGCCTGCGATGGATGGAGCAGTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAA
AAAAGTGATCAGCATGGAAAGTTTTTATGGGGAAATTATAACTCCAAGTGGGTGCATTGGTTTAAAAATGGATCACAATGATAGAGTTCT
TCATGAATGTTTACAAGTTGTAAGGAATACCGTTAGTGAAAGAGGAAAAGAAGTGGGTTCTGAAAATGCAGTTTCCCATCCAATGATTTT
GATAACAAAATTCCAACTTTTCTCAATGAAACTGATGCAGTATTATTTGTGCAAATAAAATGTGTCATAAATATGCAAAGAAAGGGAGAC
ATACTGTTCTTATCTTGAATATGTGCATTTAAATGAATTGTCCAAAATGCATAAATGCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAA

>50669_50669_2_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000217246_SPTLC3_chr20_13090759_ENST00000399002_length(amino acids)=385AA_BP=108
MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKV
SLYRGDITLLEVDAIVNADTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPT
GRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKN
TRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLL

--------------------------------------------------------------
>50669_50669_3_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000310348_SPTLC3_chr20_13090759_ENST00000378194_length(transcript)=966nt_BP=271nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG
GTGGAGGGTGTCTACAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAG
AGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAA
GATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTG
GTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTC
GGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTGAGTACACCACAGGCCAACGGGATCTCAGTACCAGTAC
CTTGGATTCAAAGCAAGTCCTTTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCTCTTGGGTTATTTAGGAAAACAACACTGACAAAAGT

>50669_50669_3_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000310348_SPTLC3_chr20_13090759_ENST00000378194_length(amino acids)=166AA_BP=
MEKDSHPGGGCLQDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVV

--------------------------------------------------------------
>50669_50669_4_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000310348_SPTLC3_chr20_13090759_ENST00000399002_length(transcript)=3001nt_BP=271nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG
GTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATA
GATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTC
ATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCAT
AGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACT
CAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAAT
GAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTG
GTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACG
GTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAG
ACGAGCTTTGAACTCGAAGATTAAGTTTCCTGGTCCTGAATGACACATAAAGACTTTGCGAGAAAGACCTCCCTCCTTGCCTCACAAGGA
ATATAAATGGATTTCTCCCCCTTCCTCAGGACAATTTTGGTTCCCAGACCAGCTTGATTGAACTGAGGGAGACGTTGTTGTTTTTAATGT
CTCCAGCTTGGACTGCAGAGACAAAAACATGATTCCAGATTTAAGTCTCTCTTCTTCCAAGTATTCTACTAGAAATACACACACACACAC
ACACACACTTCTGAGAATATTTTTAATGGCAATAAGCCTGTGTTTTAGCTGCTACTGTGCAGACCCTTTCAGGGATTCCAACCAAATGCA
AATGAGAGAATTTAAAATTTTTATTCAGTAAGTTCACTATGTGTTTACTTATTCCATCTGCAGATGTAAGTGAGTGTGGTGGACAGTAGC
CACCTTCCTTGTTCCACTCATAAAAGCATCAGCTAGATCTCATCTGTATCATGGGAAGTTCCAGGCAGGAGGGTAAAGAAATGTTGTTTC
TACCATTTGTCACATTTGGACGTTTTTCACAGACAAGTGTCAAAAGACATAGTTAATGTTTCGAGGGGGAAAGCAGAACTGATCAACTGC
GACTAGAGACGTCTTTGAAGGAAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAGTTTTACAGCTGAGCTTTTGAGGTTTGGAAAATTCA
AGATGTTTGTTTCATAAGAAAAGGGGCAGAAAGCAAGCACAAGACACTTTTAGGTCTAGACTAAAATGGTAGTTACAACAATTTGAACCT
TGTTGGTGCAGTGCACGGTGAATGCTTACCCTGCACAGCCTCTATTACCTTAAGGAATTAGTTGTCATTTTCCTATTGAATTTTGAGTAA
ATGGTGAAATTCAGTGTCCTTTAGAATCGACTCCCAAGACTATATTTGAAGAATGCATTGATTCAAGAAGGACATTTAAAAGCAAATTCT
GACTTTTTCAAGACCAACACACTTGTTTAGGCCTATTAAATTGTACTATCACTTGTTACATGCCCTCTGAATTGGGAGAAAGTGGGCTTG
CACACTTTGAGGTAACTAACTGTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCCTTCTCAACATGAACACAAACCTCTATGGAAAAGTA
GCCTCTTGTTAATCTGATCTAGTTTGTATGGAAAAAGCCCATGGAGAACCTTATCTTTAACAAGCTCCCAGAGGGTGCCCAGATTTGGAA
ATTCTAGAGAGCAGTGGTGACCTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAGTTGCAGAACATTCCACTCCATCAAATGACACTGTA
AACAAATCACTTCAAGAGAGGCTTGGTTTTGTGTGGCACAGATGGACCCAAGCTTTCATGCTGTGCACTGAGATAGAAACTCCACCCGCA
GCGCCTGCGATGGATGGAGCAGTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAAAAAAGTGATCAGCATGGAAAGTTTTTATGGGGAAA
TTATAACTCCAAGTGGGTGCATTGGTTTAAAAATGGATCACAATGATAGAGTTCTTCATGAATGTTTACAAGTTGTAAGGAATACCGTTA
GTGAAAGAGGAAAAGAAGTGGGTTCTGAAAATGCAGTTTCCCATCCAATGATTTTGATAACAAAATTCCAACTTTTCTCAATGAAACTGA
TGCAGTATTATTTGTGCAAATAAAATGTGTCATAAATATGCAAAGAAAGGGAGACATACTGTTCTTATCTTGAATATGTGCATTTAAATG
AATTGTCCAAAATGCATAAATGCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAAAAGACAGCGAGATATCTAGTCCTTCCACAAGGTAT

>50669_50669_4_MACROD2-SPTLC3_MACROD2_chr20_14066374_ENST00000310348_SPTLC3_chr20_13090759_ENST00000399002_length(amino acids)=367AA_BP=90
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
DTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVL
MGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGN
ENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDE

--------------------------------------------------------------
>50669_50669_5_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000217246_SPTLC3_chr20_13071731_ENST00000378194_length(transcript)=1610nt_BP=696nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGT
TGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAAGCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCAT
TAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAGTTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAA
TCTTCAAACACAACAACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAA
AGATTCTCATCCTGGTGGAGGGTGTCTACAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAG
CCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACT
TGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCT
TCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCC
CCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTGAGTACACCACAGGCCAACGGGAT
CTCAGTACCAGTACCTTGGATTCAAAGCAAGTCCTTTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCTCTTGGGTTATTTAGGAAAACA

>50669_50669_5_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000217246_SPTLC3_chr20_13071731_ENST00000378194_length(amino acids)=245AA_BP=118
MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKV
SLYRGDITLLEVDAIVNAANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARL

--------------------------------------------------------------
>50669_50669_6_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000217246_SPTLC3_chr20_13071731_ENST00000399002_length(transcript)=3645nt_BP=696nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGT
TGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAAGCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCAT
TAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAGTTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAA
TCTTCAAACACAACAACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAA
AGATTCTCATCCTGGTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGG
CTTACCTCTACATAGATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATG
AAGTTGATGTGCTCATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTAC
GGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGAC
TGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCA
TTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGA
AAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGG
AGATGTTAGACACGGTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTG
AGCTCTATGATGAGACGAGCTTTGAACTCGAAGATTAAGTTTCCTGGTCCTGAATGACACATAAAGACTTTGCGAGAAAGACCTCCCTCC
TTGCCTCACAAGGAATATAAATGGATTTCTCCCCCTTCCTCAGGACAATTTTGGTTCCCAGACCAGCTTGATTGAACTGAGGGAGACGTT
GTTGTTTTTAATGTCTCCAGCTTGGACTGCAGAGACAAAAACATGATTCCAGATTTAAGTCTCTCTTCTTCCAAGTATTCTACTAGAAAT
ACACACACACACACACACACACTTCTGAGAATATTTTTAATGGCAATAAGCCTGTGTTTTAGCTGCTACTGTGCAGACCCTTTCAGGGAT
TCCAACCAAATGCAAATGAGAGAATTTAAAATTTTTATTCAGTAAGTTCACTATGTGTTTACTTATTCCATCTGCAGATGTAAGTGAGTG
TGGTGGACAGTAGCCACCTTCCTTGTTCCACTCATAAAAGCATCAGCTAGATCTCATCTGTATCATGGGAAGTTCCAGGCAGGAGGGTAA
AGAAATGTTGTTTCTACCATTTGTCACATTTGGACGTTTTTCACAGACAAGTGTCAAAAGACATAGTTAATGTTTCGAGGGGGAAAGCAG
AACTGATCAACTGCGACTAGAGACGTCTTTGAAGGAAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAGTTTTACAGCTGAGCTTTTGAG
GTTTGGAAAATTCAAGATGTTTGTTTCATAAGAAAAGGGGCAGAAAGCAAGCACAAGACACTTTTAGGTCTAGACTAAAATGGTAGTTAC
AACAATTTGAACCTTGTTGGTGCAGTGCACGGTGAATGCTTACCCTGCACAGCCTCTATTACCTTAAGGAATTAGTTGTCATTTTCCTAT
TGAATTTTGAGTAAATGGTGAAATTCAGTGTCCTTTAGAATCGACTCCCAAGACTATATTTGAAGAATGCATTGATTCAAGAAGGACATT
TAAAAGCAAATTCTGACTTTTTCAAGACCAACACACTTGTTTAGGCCTATTAAATTGTACTATCACTTGTTACATGCCCTCTGAATTGGG
AGAAAGTGGGCTTGCACACTTTGAGGTAACTAACTGTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCCTTCTCAACATGAACACAAACC
TCTATGGAAAAGTAGCCTCTTGTTAATCTGATCTAGTTTGTATGGAAAAAGCCCATGGAGAACCTTATCTTTAACAAGCTCCCAGAGGGT
GCCCAGATTTGGAAATTCTAGAGAGCAGTGGTGACCTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAGTTGCAGAACATTCCACTCCAT
CAAATGACACTGTAAACAAATCACTTCAAGAGAGGCTTGGTTTTGTGTGGCACAGATGGACCCAAGCTTTCATGCTGTGCACTGAGATAG
AAACTCCACCCGCAGCGCCTGCGATGGATGGAGCAGTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAAAAAAGTGATCAGCATGGAAAG
TTTTTATGGGGAAATTATAACTCCAAGTGGGTGCATTGGTTTAAAAATGGATCACAATGATAGAGTTCTTCATGAATGTTTACAAGTTGT
AAGGAATACCGTTAGTGAAAGAGGAAAAGAAGTGGGTTCTGAAAATGCAGTTTCCCATCCAATGATTTTGATAACAAAATTCCAACTTTT
CTCAATGAAACTGATGCAGTATTATTTGTGCAAATAAAATGTGTCATAAATATGCAAAGAAAGGGAGACATACTGTTCTTATCTTGAATA
TGTGCATTTAAATGAATTGTCCAAAATGCATAAATGCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAAAAGACAGCGAGATATCTAGTC

>50669_50669_6_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000217246_SPTLC3_chr20_13071731_ENST00000399002_length(amino acids)=468AA_BP=118
MPVSLGNLQLKASHPHGNMYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKV
SLYRGDITLLEVDAIVNAANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARL
SGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEF
FGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQR
LQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRH

--------------------------------------------------------------
>50669_50669_7_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000310348_SPTLC3_chr20_13071731_ENST00000378194_length(transcript)=1215nt_BP=301nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGGACC
TCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAA
AACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGC
AGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAA
GGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAG
CGGCACATACCCGGGAGATGTTAGACACGGTGAGTACACCACAGGCCAACGGGATCTCAGTACCAGTACCTTGGATTCAAAGCAAGTCCT
TTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCTCTTGGGTTATTTAGGAAAACAACACTGACAAAAGTCACTGCCAAAAAACAAGAGCT

>50669_50669_7_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000310348_SPTLC3_chr20_13071731_ENST00000378194_length(amino acids)=227AA_BP=100
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
ANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEK

--------------------------------------------------------------
>50669_50669_8_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000310348_SPTLC3_chr20_13071731_ENST00000399002_length(transcript)=3250nt_BP=301nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGCATG
GAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATAGATGAAGCTCACAGTATTGGG
GCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTCATGGGCACATTCACCAAAAGT
TTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCC
ATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAG
CAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCT
CTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCC
ACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTTTTAGAAGCTCTTGATGAA
ATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAGACGAGCTTTGAACTCGAAGAT
TAAGTTTCCTGGTCCTGAATGACACATAAAGACTTTGCGAGAAAGACCTCCCTCCTTGCCTCACAAGGAATATAAATGGATTTCTCCCCC
TTCCTCAGGACAATTTTGGTTCCCAGACCAGCTTGATTGAACTGAGGGAGACGTTGTTGTTTTTAATGTCTCCAGCTTGGACTGCAGAGA
CAAAAACATGATTCCAGATTTAAGTCTCTCTTCTTCCAAGTATTCTACTAGAAATACACACACACACACACACACACTTCTGAGAATATT
TTTAATGGCAATAAGCCTGTGTTTTAGCTGCTACTGTGCAGACCCTTTCAGGGATTCCAACCAAATGCAAATGAGAGAATTTAAAATTTT
TATTCAGTAAGTTCACTATGTGTTTACTTATTCCATCTGCAGATGTAAGTGAGTGTGGTGGACAGTAGCCACCTTCCTTGTTCCACTCAT
AAAAGCATCAGCTAGATCTCATCTGTATCATGGGAAGTTCCAGGCAGGAGGGTAAAGAAATGTTGTTTCTACCATTTGTCACATTTGGAC
GTTTTTCACAGACAAGTGTCAAAAGACATAGTTAATGTTTCGAGGGGGAAAGCAGAACTGATCAACTGCGACTAGAGACGTCTTTGAAGG
AAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAGTTTTACAGCTGAGCTTTTGAGGTTTGGAAAATTCAAGATGTTTGTTTCATAAGAAA
AGGGGCAGAAAGCAAGCACAAGACACTTTTAGGTCTAGACTAAAATGGTAGTTACAACAATTTGAACCTTGTTGGTGCAGTGCACGGTGA
ATGCTTACCCTGCACAGCCTCTATTACCTTAAGGAATTAGTTGTCATTTTCCTATTGAATTTTGAGTAAATGGTGAAATTCAGTGTCCTT
TAGAATCGACTCCCAAGACTATATTTGAAGAATGCATTGATTCAAGAAGGACATTTAAAAGCAAATTCTGACTTTTTCAAGACCAACACA
CTTGTTTAGGCCTATTAAATTGTACTATCACTTGTTACATGCCCTCTGAATTGGGAGAAAGTGGGCTTGCACACTTTGAGGTAACTAACT
GTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCCTTCTCAACATGAACACAAACCTCTATGGAAAAGTAGCCTCTTGTTAATCTGATCTA
GTTTGTATGGAAAAAGCCCATGGAGAACCTTATCTTTAACAAGCTCCCAGAGGGTGCCCAGATTTGGAAATTCTAGAGAGCAGTGGTGAC
CTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAGTTGCAGAACATTCCACTCCATCAAATGACACTGTAAACAAATCACTTCAAGAGAGG
CTTGGTTTTGTGTGGCACAGATGGACCCAAGCTTTCATGCTGTGCACTGAGATAGAAACTCCACCCGCAGCGCCTGCGATGGATGGAGCA
GTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAAAAAAGTGATCAGCATGGAAAGTTTTTATGGGGAAATTATAACTCCAAGTGGGTGCA
TTGGTTTAAAAATGGATCACAATGATAGAGTTCTTCATGAATGTTTACAAGTTGTAAGGAATACCGTTAGTGAAAGAGGAAAAGAAGTGG
GTTCTGAAAATGCAGTTTCCCATCCAATGATTTTGATAACAAAATTCCAACTTTTCTCAATGAAACTGATGCAGTATTATTTGTGCAAAT
AAAATGTGTCATAAATATGCAAAGAAAGGGAGACATACTGTTCTTATCTTGAATATGTGCATTTAAATGAATTGTCCAAAATGCATAAAT
GCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAAAAGACAGCGAGATATCTAGTCCTTCCACAAGGTATGGAAAGCAATAAACATCTTCC

>50669_50669_8_MACROD2-SPTLC3_MACROD2_chr20_14474154_ENST00000310348_SPTLC3_chr20_13071731_ENST00000399002_length(amino acids)=450AA_BP=100
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
ANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEK
LLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKS
FGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVP
LLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELED

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MACROD2-SPTLC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MACROD2-SPTLC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MACROD2-SPTLC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source