Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAGED2-SCAMP4 (FusionGDB2 ID:50768)

Fusion Gene Summary for MAGED2-SCAMP4

Fusion gene summary

Fusion gene information	Fusion gene name: MAGED2-SCAMP4
	Fusion gene ID: 50768
		Hgene	Tgene
	Gene symbol	MAGED2	SCAMP4
	Gene ID	10916	113178
	Gene name	MAGE family member D2	secretory carrier membrane protein 4
	Synonyms	11B6\|BARTS5\|BCG-1\|BCG1\|HCA10\|MAGE-D2	SCAMP-4
	Cytomap	Xp11.21	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	melanoma-associated antigen D2MAGE-D2 antigenbreast cancer-associated gene 1 proteinhepatocellular carcinoma-associated protein JCL-1melanoma antigen family D, 2melanoma antigen family D2	secretory carrier-associated membrane protein 4
	Modification date	20200313	20200313
	UniProtAcc	Q9UNF1	.
	Ensembl transtripts involved in fusion gene	ENST00000347546, ENST00000375058, ENST00000375060, ENST00000375068, ENST00000218439, ENST00000375053, ENST00000375062, ENST00000396224, ENST00000497484,	ENST00000409472, ENST00000414057, ENST00000316097,
Fusion gene scores	* DoF score	13 X 9 X 4=468	2 X 2 X 2=8
	# samples	13	2
	** MAII score	log2(13/468*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: MAGED2 [Title/Abstract] AND SCAMP4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAGED2(54842445)-SCAMP4(1917693), # samples:1
Anticipated loss of major functional domain due to fusion event.	MAGED2-SCAMP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MAGED2-SCAMP4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAGED2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCAMP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-7745-01A	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+

Top

Fusion Gene ORF analysis for MAGED2-SCAMP4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000347546	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
5CDS-3UTR	ENST00000347546	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
5CDS-3UTR	ENST00000375058	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
5CDS-3UTR	ENST00000375058	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
5CDS-3UTR	ENST00000375060	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
5CDS-3UTR	ENST00000375060	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
5CDS-3UTR	ENST00000375068	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
5CDS-3UTR	ENST00000375068	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
Frame-shift	ENST00000375058	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
Frame-shift	ENST00000375060	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
Frame-shift	ENST00000375068	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
In-frame	ENST00000347546	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3CDS	ENST00000218439	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3CDS	ENST00000375053	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3CDS	ENST00000375062	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3CDS	ENST00000396224	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3CDS	ENST00000497484	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000218439	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000218439	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000375053	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000375053	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000375062	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000375062	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000396224	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000396224	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000497484	ENST00000409472	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+
intron-3UTR	ENST00000497484	ENST00000414057	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000347546

MAGED2

chrX

54842445

ENST00000316097

SCAMP4

chr19

1917693

4593

2177

1851

588

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000347546	ENST00000316097	MAGED2	chrX	54842445	-	SCAMP4	chr19	1917693	+	0.012705399	0.9872946

Top

Fusion Genomic Features for MAGED2-SCAMP4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MAGED2-SCAMP4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:54842445/chr19:1917693)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAGED2 Q9UNF1	.
FUNCTION: Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269\|PubMed:27120771}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000375058

215_258

652

628.3333333333334

Compositional bias

Note=Arg-rich

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000375068

215_258

652

581.3333333333334

Compositional bias

Note=Arg-rich

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000375058

279_478

652

628.3333333333334

Domain

MAGE

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000375068

279_478

652

581.3333333333334

Domain

MAGE

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000316097

170_229

230.0

Topological domain

Cytoplasmic

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000316097

1_39

230.0

Topological domain

Cytoplasmic

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000409472

170_229

196.0

Topological domain

Cytoplasmic

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000409472

1_39

196.0

Topological domain

Cytoplasmic

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000316097

105_125

230.0

Transmembrane

Helical

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000316097

149_169

230.0

Transmembrane

Helical

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000316097

40_60

230.0

Transmembrane

Helical

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000316097

61_81

230.0

Transmembrane

Helical

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000409472

105_125

196.0

Transmembrane

Helical

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000409472

149_169

196.0

Transmembrane

Helical

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000409472

40_60

196.0

Transmembrane

Helical

Tgene

SCAMP4

chrX:54842445

chr19:1917693

ENST00000409472

61_81

196.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000218439

215_258

607.0

Compositional bias

Note=Arg-rich

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000375053

215_258

607.0

Compositional bias

Note=Arg-rich

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000396224

215_258

607.0

Compositional bias

Note=Arg-rich

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000218439

279_478

607.0

Domain

MAGE

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000375053

279_478

607.0

Domain

MAGE

Hgene

MAGED2

chrX:54842445

chr19:1917693

ENST00000396224

279_478

607.0

Domain

MAGE

Top

Fusion Gene Sequence for MAGED2-SCAMP4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50768_50768_1_MAGED2-SCAMP4_MAGED2_chrX_54842445_ENST00000347546_SCAMP4_chr19_1917693_ENST00000316097_length(transcript)=4593nt_BP=2177nt
GACTTCGAGAGGGACTTAGAGAAGGCAGACGCATCCCGAACTCGCTGGAGGACAAGGCTCAGCTCTTGCCAGGCCAAATTGAGACATGTC
TGACACAAGCGAGAGTGGTGCAGGTCTAACTCGCTTCCAGGCTGAAGCTTCAGAAAAGGACAGTAGCTCGATGATGCAGACTCTGTTGAC
AGTGACCCAGAATGTGGAGGTCCCAGAGACACCGAAGGCCTCAAAGGCCACAGAGGTCTCAAAGACCCCAGAGGCTCGGGAGGCACCTGC
CACCCAGGCCTCATCTACTACTCAGCTGACTGATACCCAGGTTCTGGCAGCTGAAAACAAGAGTCTAGCAGCTGACACCAAGAAACAGAA
TGCTGACCCGCAGGCTGTGACAATGCCTGCCACTGAGACCAAAAAGGTCAGCCATGTGGCTGATACAAAGGTCAATACAAAGGCTCAGGA
GACTGAGGCTGCACCCTCTCAGGCCCCAGCAGATGAACCTGAGCCTGAGAGTGCAGCTGCCCAGTCTCAGGAGAATCAGGATACTCGGCC
CAAGGTCAAAGCCAAGAAAGCCCGAAAGGTGAAGCATCTGGATGGGGAAGAGGATGGCAGCAGTGATCAGAGTCAGGCTTCTGGAACCAC
AGGTGGCCGAAGGGTCTCAAAGGCCCTAATGGCCTCAATGGCCCGCAGGGCTTCAAGGGGTCCCATAGCCTTTTGGGCCCGCAGGGCATC
AAGGACTCGGTTGGCTGCTTGGGCCCGGAGAGCCTTGCTCTCCCTGAGATCACCTAAAGCCCGTAGGGGCAAGGCTCGCCGTAGAGCTGC
CAAGCTCCAGTCATCCCAAGAGCCTGAAGCACCACCACCTCGGGATGTGGCCCTTTTGCAAGGGAGGGCAAATGATTTGGTGAAGTACCT
TTTGGCTAAAGACCAGACGAAGATTCCCATCAAGCGCTCGGACATGCTGAAGGACATCATCAAAGAATACACTGATGTGTACCCCGAAAT
CATTGAACGAGCAGGCTATTCCTTGGAGAAGGTATTTGGGATTCAATTGAAGGAAATTGATAAGAATGACCACTTGTACATTCTTCTCAG
CACCTTAGAGCCCACTGATGCAGGCATACTGGGAACGACTAAGGACTCACCCAAGCTGGGTCTGCTCATGGTGCTTCTTAGCATCATCTT
CATGAATGGAAATCGGTCCAGTGAGGCTGTCATCTGGGAGGTGCTGCGCAAGTTGGGGCTGCGCCCTGGGATACATCATTCACTCTTTGG
GGACGTGAAGAAGCTCATCACTGATGAGTTTGTGAAGCAGAAGTACCTGGACTATGCCAGAGTCCCCAATAGCAATCCCCCTGAATATGA
GTTCTTCTGGGGCCTGCGCTCTTACTATGAGACCAGCAAGATGAAAGTCCTCAAGTTTGCCTGCAAGGTACAAAAGAAGGATCCCAAGGA
ATGGGCAGCTCAGTACCGAGAGGCGATGGAAGCGGATTTGAAGGCTGCAGCTGAGGCTGCAGCTGAAGCCAAGGCTAGGGCCGAGATTAG
AGCTCGAATGGGCATTGGGCTCGGCTCGGAGAATGCTGCCGGGCCCTGCAACTGGGACGAAGCTGATATCGGACCCTGGGCCAAAGCCCG
GATCCAGGCGGGAGCAGAAGCTAAAGCCAAAGCCCAAGAGAGTGGCAGTGCCAGCACTGGTGCCAGTACCAGTACCAATAACAGTGCCAG
TGCCAGTGCCAGCACCAGTGGTGGCTTCAGTGCTGGTGCCAGCCTGACCGCCACTCTCACATTTGGGCTCTTCGCTGGCCTTGGTGGAGC
TGGTGCCAGCACCAGTGGCAGCTCTGGTGCCTGTGGTTTCTCCTACAAGTGAGATTTTAGGTATCTGCCTTGGTTTCAGTGGGGACATCT
GGGGCTTATGGGGCTGGGATGAGGAGCTGGATGATTCTAGGAAGGCCCAAGTTGGAGAATGATGTGGAGAGTGTGCCAAGACACTGCTTT
TGGCATTTTATTCCTTTCTGTTTGCTGGATGTCAATTGACCCTTTTATTTTCTCTTACTTGTGTTTTCAGATATTGTTAATCCTGCCAGT
CTTTCTCTTCAAGCCAGGGTGCATCCTCAGAAACCTACTCAACACAGCACTCTAGGCAGCCACTATCAATCAATTGAAGTTGACACTCTG
CATTAAATCTATTTGCCAAAAGGAGAACAACTTCCCGCCACTGCCCAAGTTCATCCCTGTGAAGCCCTGCTTCTACCAGAACTTCTCCGA
CGAGATCCCAGTGGAGCACCAGGTCCTGGTGAAGAGGATCTACCGGCTGTGGATGTTTTACTGCGCCACCCTCGGCGTCAACCTCATTGC
CTGCCTGGCCTGGTGGATCGGCGGAGGCTCGGGGACCAACTTCGGCCTGGCCTTCGTGTGGCTGCTCCTGTTCACGCCTTGCGGCTACGT
GTGCTGGTTCCGGCCTGTCTACAAGGCCTTCCGAGCCGACAGCTCCTTTAATTTCATGGCGTTTTTCTTCATCTTCGGAGCCCAGTTTGT
CCTGACCGTCATCCAGGCGATTGGCTTCTCCGGCTGGGGCGCGTGCGGCTGGCTGTCGGCAATTGGATTCTTCCAGTACAGCCCGGGCGC
TGCCGTGGTCATGCTGCTTCCAGCCATCATGTTCTCCGTGTCGGCTGCCATGATGGCCATCGCGATCATGAAGGTGCACAGGATCTACCG
AGGGGCTGGCGGAAGCTTCCAGAAGGCACAGACGGAGTGGAACACGGGCACTTGGCGGAACCCACCGTCGAGGGAGGCCCAGTACAACAA
CTTCTCAGGCAACAGCCTGCCCGAGTACCCCACTGTGCCCAGCTACCCGGGCAGTGGCCAGTGGCCTTAGAGGGAGCCTGCCCTGCCCCC
ACCGCCCACCACCTCCTCCCCTTCATTCCTGCTGCTACCCCTGGTCCCGAGGGCTGGGAGTACCTGGGGCCCCATCCCCCCAGCTGGGAT
GGTGGAAGCCGGTGGTGGCCACGGACCGCCCCCCTCCTGCCAGGGCCACAGAACCCGTGTTCATCTCATCCGAGAGCGGAGTTCCTCACA
AGCACTCCCCAGCAGCCCTTGGCCTCTGCCGTCCACAGGACGCCCTCTTGCTCCCGGAAACGTGTGGTCACCCGCCGTCCACTGCACGGC
TGGTACGGCCTTGTCTTCAGGTCTCGAGGCCTGACTCCGGGGGACAGGTGGCAGCAGGTCGGCCGCCCTCCCGTCCTCCCAGAGCTGCTG
GCGCTGAGGTCAGAGCGGGTCTGATGGGGAGCTCCGTCTCACCGGCCACCCGCCGTCACCATGGCAGATGCCCTTGGCCGGAACTAATAA
GAGGCGTCGGGGCCAGCTTCCGGTCCCCTGCAGTGATAGAGGGCTTGGTGCCTAGCTGAGTCCTCGCTGTCCCCGCCATCCCCTGATCTG
TGCGGCTCCAGCCTCGCCCCCTCCCCACGTGCACCATACCTGGGGAGTTCCTGGTCCAGGGTATCCTGGGGCCACCCTCCCTGCCTCCAA
AACAGGGATCCCTGGCAGGCTGTCTTTCCACGCCCCTGAGTTCAGAGTCGGGGACCCAGGCCAGGTCGGGAGCACAGCCGCTCCCCAAAC
CCAGCAAACCGGCAGAGAGCCGGTTTCCCAGCAGCCGGAGCCCTGCAGGAGAGGCCTTTGTGTTTTGTTTTGTTTTGTTTTTTCTCTTTT
GAGACAAGAGTTTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCTGCCTCCCGTGTTCAAGCAGTT
CTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGTTGCCTGCCACCACGCCCAGCTAATTTTTATATTTTTAGTACAGATGGGGTTTC
ACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATAATAGGTGTCAGCC
ACCGCGCCCAGCCTGGAGTGGCCTTTTATGAGAGGGGACCCGTCAAATCTGTGCCTTATGGAGGGGTCCGGCAGCGGCCACAATTGTCTT
GTCCCCTCACCCCCCAACTCCCCCTGGAACACCTCTCCCAGGCAAGACATTTTCACAGCACCATTCACAACGGTTGGGCCAAAAAGAAAC
TTTTCCTTCATCATTTCCTGCACTCGCTGACCACAACTTTGGACACCCCAGGCTGCCACCCCTCCCCACCCGTTCACCCCCAGGATGCTG
TTGCTGTAGGACGCCTGCTGCCCTGGAGCCCTCCCCAGGATGTGAGCCAGTCCCCTCGCTGGTACGGAATGCCGCTGGGTGCCCGGAGGC
GGCCATGGTGTCTCGATGGACGGCAGCCAGGATGGAGCACCCATGGGTCTCACGGCCATGCTTCAGGGTCTTCAGGTCCTGCCCCCGGCC
AGTCTGCCAAGAGGCACCCCCTTCCCCAGCCTCTCGCCTGCACTGATGCAGACAAAATCTCACCTGGCAGGCCCAACCCCCCCCCACCCC
TCCCCCGCCGTGTGTGGCCCCTCGCCGCATCGTTGGGGTTTTGTTATGTGAAAATATCCTGGAAATAAATACATGTTTCTGCACTTAGAG

>50768_50768_1_MAGED2-SCAMP4_MAGED2_chrX_54842445_ENST00000347546_SCAMP4_chr19_1917693_ENST00000316097_length(amino acids)=588AA_BP=
MSDTSESGAGLTRFQAEASEKDSSSMMQTLLTVTQNVEVPETPKASKATEVSKTPEAREAPATQASSTTQLTDTQVLAAENKSLAADTKK
QNADPQAVTMPATETKKVSHVADTKVNTKAQETEAAPSQAPADEPEPESAAAQSQENQDTRPKVKAKKARKVKHLDGEEDGSSDQSQASG
TTGGRRVSKALMASMARRASRGPIAFWARRASRTRLAAWARRALLSLRSPKARRGKARRRAAKLQSSQEPEAPPPRDVALLQGRANDLVK
YLLAKDQTKIPIKRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSI
IFMNGNRSSEAVIWEVLRKLGLRPGIHHSLFGDVKKLITDEFVKQKYLDYARVPNSNPPEYEFFWGLRSYYETSKMKVLKFACKVQKKDP
KEWAAQYREAMEADLKAAAEAAAEAKARAEIRARMGIGLGSENAAGPCNWDEADIGPWAKARIQAGAEAKAKAQESGSASTGASTSTNNS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MAGED2-SCAMP4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MAGED2-SCAMP4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MAGED2-SCAMP4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source