Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAGI2-VWC2 (FusionGDB2 ID:50811)

Fusion Gene Summary for MAGI2-VWC2

Fusion gene summary

Fusion gene information	Fusion gene name: MAGI2-VWC2
	Fusion gene ID: 50811
		Hgene	Tgene
	Gene symbol	MAGI2	VWC2
	Gene ID	9863	375567
	Gene name	membrane associated guanylate kinase, WW and PDZ domain containing 2	von Willebrand factor C domain containing 2
	Synonyms	ACVRIP1\|AIP-1\|AIP1\|ARIP1\|MAGI-2\|NPHS15\|SSCAM	PSST739\|UNQ739
	Cytomap	7q21.11	7p12.2
	Type of gene	protein-coding	protein-coding
	Description	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2activin receptor interacting protein 1atrophin-1-interacting protein 1atrophin-1-interacting protein Amembrane-associated guanylate kinase inverted 2	brorinbrain-specific chordin-like proteinvon Willebrand factor C domain-containing protein 2
	Modification date	20200320	20200313
	UniProtAcc	Q86UL8	.
	Ensembl transtripts involved in fusion gene	ENST00000354212, ENST00000419488, ENST00000522391, ENST00000517762, ENST00000535697, ENST00000536571,	ENST00000340652,
Fusion gene scores	* DoF score	13 X 12 X 5=780	5 X 3 X 4=60
	# samples	13	6
	** MAII score	log2(13/780*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/60*10)=0
Context	PubMed: MAGI2 [Title/Abstract] AND VWC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAGI2(79082336)-VWC2(49842307), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAGI2	GO:0002092	positive regulation of receptor internalization	11526121
Hgene	MAGI2	GO:0032516	positive regulation of phosphoprotein phosphatase activity	10760291
Hgene	MAGI2	GO:0051898	negative regulation of protein kinase B signaling	10760291

Fusion gene breakpoints across MAGI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VWC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-7477-01B	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+

Top

Fusion Gene ORF analysis for MAGI2-VWC2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000354212	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+
In-frame	ENST00000419488	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+
In-frame	ENST00000522391	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+
intron-3CDS	ENST00000517762	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+
intron-3CDS	ENST00000535697	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+
intron-3CDS	ENST00000536571	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000419488	MAGI2	chr7	79082336	-	ENST00000340652	VWC2	chr7	49842307	+	10583	536	570	190	126
ENST00000354212	MAGI2	chr7	79082336	-	ENST00000340652	VWC2	chr7	49842307	+	10602	555	589	209	126
ENST00000522391	MAGI2	chr7	79082336	-	ENST00000340652	VWC2	chr7	49842307	+	10498	451	485	105	126

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000419488	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+	0.024762867	0.9752372
ENST00000354212	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+	0.024743605	0.9752563
ENST00000522391	ENST00000340652	MAGI2	chr7	79082336	-	VWC2	chr7	49842307	+	0.025749467	0.97425056

Top

Fusion Genomic Features for MAGI2-VWC2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MAGI2-VWC2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:79082336/chr7:49842307)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAGI2 Q86UL8	.
FUNCTION: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. {ECO:0000269\|PubMed:10760291}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

17_101

100

1456.0

Domain

PDZ 1

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

17_101

100

1442.0

Domain

PDZ 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

1015_1118

100

1456.0

Compositional bias

Note=Pro-rich

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

1340_1430

100

1456.0

Compositional bias

Note=Ala-rich

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

1015_1118

100

1442.0

Compositional bias

Note=Pro-rich

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

1340_1430

100

1442.0

Compositional bias

Note=Ala-rich

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

109_283

100

1456.0

Domain

Guanylate kinase-like

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

1147_1229

100

1456.0

Domain

PDZ 6

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

302_335

100

1456.0

Domain

WW 1

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

348_381

100

1456.0

Domain

WW 2

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

426_510

100

1456.0

Domain

PDZ 2

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

605_683

100

1456.0

Domain

PDZ 3

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

778_860

100

1456.0

Domain

PDZ 4

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000354212

920_1010

100

1456.0

Domain

PDZ 5

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

109_283

100

1442.0

Domain

Guanylate kinase-like

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

1147_1229

100

1442.0

Domain

PDZ 6

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

302_335

100

1442.0

Domain

WW 1

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

348_381

100

1442.0

Domain

WW 2

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

426_510

100

1442.0

Domain

PDZ 2

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

605_683

100

1442.0

Domain

PDZ 3

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

778_860

100

1442.0

Domain

PDZ 4

Hgene

MAGI2

chr7:79082336

chr7:49842307

ENST00000419488

920_1010

100

1442.0

Domain

PDZ 5

Tgene

VWC2

chr7:79082336

chr7:49842307

ENST00000340652

120_127

232

326.0

Compositional bias

Note=Poly-Ala

Tgene

VWC2

chr7:79082336

chr7:49842307

ENST00000340652

153_212

232

326.0

Domain

VWFC 1

Tgene

VWC2

chr7:79082336

chr7:49842307

ENST00000340652

216_274

232

326.0

Domain

VWFC 2

Tgene

VWC2

chr7:79082336

chr7:49842307

ENST00000340652

114_116

232

326.0

Motif

Mediates cell adhesion

Top

Fusion Gene Sequence for MAGI2-VWC2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50811_50811_1_MAGI2-VWC2_MAGI2_chr7_79082336_ENST00000354212_VWC2_chr7_49842307_ENST00000340652_length(transcript)=10602nt_BP=555nt
AGCCTTGAGTGTCATTCAAGGGACAGCACAACCTCATCCAAGCTCTCCTACCTCTGCCCAGCCGTCCCTCTCATCCTCCCCATTCCTCGT
CCACACTCCATCCAAAGAAGAGGGAAAGCACCGAATAGAGGGGGGCGAAGGCAAAGTCTGCTGTTCTTCCCCCTGGGCCCCCTTGCTCCT
CCATCCTCATTCTCTCACCACCAGCCCCCCTAACCCCAAGGAGCCCAGGAACTGAGGCGACTCGCCCCACTGCCATGTCCAAAAGCTTGA
AAAAGAAAAGCCACTGGACTAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTTGAACTGAAGGGGGGCG
CCGAGAATGGACAGTTCCCCTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTGGTGTCGGAGGAGCTGC
TGCTGGAGGTGAACGAGACCCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAGGACCCCCTCCGGCTCA
AGTGTGTCAAGCAAGGTGTCTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTCAGCGTGTCCCCAGACG
GAGTGTGTGGACCCTGTGTACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCT
GCTGGCAGAGAAGTGAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGAGCGGCAGGCCATGTGC
ACGAGACATGAATGCAGGCAAATGTAGACGCTTCCCAGAACACAAACTCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGA
TGACTCTGGGAACTATCAGTCAAAGAAGACTTTTGATGAGGAATAATGGAAAATTGTTGGTACTTTTCCTTTTCTTGATAACAGTTACTA
CAACAGAAGGAAATGGATATATTTCAAAACATCAACAAGAACTTTGGGCATAAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAA
GTACACAAAAGTACACTATTATATATCAAATGTATTTCTATAATCCCTCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGATT
AAAAATGCTGTGTTGTCAACCGTCCTCACCGTGTACCTGCATATCTTTTTCAGTTCTGATTCCATCACCCAGGAATGTTCCCCCTGCACA
TTTTCACAGGGCAGAGTCACGCATGAATGGATCATAAGATATTAGGACCAATTTCCACTGAAACCCTGTTTAAATTCTATTTAATTACAG
ACATATCTCTAATGTTGATGTCTACTTCACATAAATATATTTCCTTTTTATAATAATATATGGCTTTTATCTGCTTCATTCTCAGTCACT
TGTGAAATGCAGGTGTAAAGATCACTAACTCACACTTTCTCAGTTCTTTCCCCTAAGCTCCTGTATTGTACACCATAGGTAAGCACATAC
ATATATTTCATTCTTATTTACATTATTTTCTCTTCTAAGGATAACTTTAATTCATTCCCTAAACTGAGGAATAAAGTAGGCTGGAAAATT
TGCATTACTGTTCCATCAAGCTGAAGCAGACAACAAAATAGGGGAGGAGTCCTTCGATTCTCCTAGGATAGTTAAGGAAAATCAAACTCC
TAAACAAGTTTATATACCTGAAATCTAAATGTGCTACAGATAACTCAGCTGTCAGTTCAGTGGAATCATATTTGTCATCAGACTTGAGTC
ATCTATCCTCCATAAACTACACAGTAAAATCTTGACTGATAACCTTGAATTAGCCACCCTTCACAAGCAGAGTGAGGAAGCAGTTATTTT
GTTAAAACAAAGCTGAAGACCAAGTGCACTCCACAACTTTCCTATAGTTATAATTCCAAACCAACTTCTTTTCTCTTCATTTGAACAGAG
AACATAAAAAGCCACTGCAAAGTCCTGCTAATCTAATTAATGCATAATAGAAAATAGTTCTACCTTTATCAATCATATCAGCATGCGGTG
TGTTGATGAAAGAGGTAATTGGAGTCTTAATAGGTGTAGGATAAAAAAAGCAAAACTATAATCACTATTAATGTCTTTAAAGGATTAAAA
TATATATAATCATTATTTGAAGCCTCTAAAGGTATTTTTCATATTTTTGTTTATTCTGAAATTTTGCATTAAGAACCTATTAAGTACAAA
GCATTGACAACAAGGGAATAAGGCTTGATTTCTTGCCTTCTTGGACTTTCGGTCTCTGGCATAAGAAGTATATGAAATCATAATGTATTG
TATTAGGAGCCAAACTAGAGACCAGCAAATGGAGATTAGAAAGCCTTCCTAATGAGAAGATGGAGAACATGAAAAAATCATTATATAAAA
AATAATTCAATCATTAAAGACTGAATAACATTCAAGAAAAATGGATACATCTATCATAATTGAAAAATTAAACTATTGTGAACCTTAGTA
AGTATAAAGATGCCACTGACTGAGTCATCAAAACACTACATATAGTCATTTAATTTTTGTCTTGTTCATAAAGAACACCTTGAGCCAAAG
GAACTACCAGTACATAGATTTCATGAAAATACTCAGGGGAATTATTAGCTAATTGTTCTCAGGTGTAATCAGCTTTCCAAAATTTAACCT
TTGTATTAAAGACTGGTAGACATTGGCCATCCCTCCTTTATTCAAGGATGGATTGTTTGAGACACAGTTATTTAAAGTTGTCGTTTTGCT
AATAAATGGCCCTAGCCCCCATGGGTAGGTGGGCCATTAGTAACCTCTTCTCTCTCCATCAGGCATGATGCAGTTAGAGACTCAGTCCAT
GCAGCTCAAAGTCTTCCTGTTTCCCTTAATAATAATTCCTACCAGAATGGATGATGAGCTCTGAAATAATTGCAATGGTGTTTTCAATGC
TGTGAGAATTTCAGAAAACCTAGTATTTTGTTGCATATAGAGAGAATGAACCCAGTATCATCTTGGGAAGTTAACTGACTCACTTGCTCT
AAACTTAGTTTGACCTGCAGGGTCACCAGCACACACTCCTAAGAGCTAAAGCTCAATGGCTGTTATTACACCAAAGTAACTCCCCTCCCC
ATCTCTGATTTCAACCCCCTCATTCCTCTCTCCTCATAGAAATAATGCATAAACCAAACACATGGAAGAACTTGGATTTTTGACACTGTA
TATACTCATTAATAATAATGGCATTATTTGCATTTTTGTCCAAGATCAACTTCTTCTTGCAGTTAGACTTTCACAAATACATAGCTATCT
CAGATTGACATTCTATTTTCCTCCCCTCTGTTGTCAGAGAACTCTTTGCTGAGATTGTCAACAACAAACTGTTCTATTCAATAAATAACC
TGAATAACTGCCCAATAAAAAAGGAAAGTATAAGTTACTCAATTTCAAAATAATATGGTTTGGAGATAGCACAGAAAAGGGGGCCTCAGA
ATTCAAGTATAGAAGTTCTGGAAAAGCCATAATCACTAAAATTCAAATAGGCCTGCTCTATAAGTACCTAATAATTGTTAAATGATTTGT
TCAAGTTAATAAACTAAATCGTGCTTACAAATGTATTAATGAATTTATTTCAAATTTTCAACCCATATTTAGATCTGAAAGTATAAAGCT
ACTTATGTAAGCAATAGAATGGTTCTGGAAATTATCTGATGTCTTAGAGGTTTTCAAGTTAAATTCATTCTTTCAGTGATAGGATATTTA
CTTGTTGGGTGGATTAACAATACTTTTTATTGACATTTCCCAGAAGTCTTGAGAAAAGTCATTTCAAAAACTTGTATTTCATCCCTGCAT
GCAAGAAGTATTAGATGCACTCCAGTCCAGGCAAGTCCTGCTATAATGTTGCAGCTAGTGCAGATGGAGAGGCACAGTGTCCTTGACATC
AAGGGGTCTGTAAGCCTTGAAACTAATTTAGGTTTGATTATAATACTTTTAATCTTTTGATACTTAGAATTTCATCACCTGCTTTGTGCA
GTAAAACATGCTAAGAAGAATTATCATGCAGTTTTAAGTTCATAACATCAATAATATGTTTAATAAACTTTCTTCCCTCGTTCTCCAACA
TAAATGTTGCATTTATATAAGGTTAAAAGTCCTAAAAAATCATAAAATTCAGATGTTTAATTTTTGTTTTTAAGCAGTGAAATGGGTTTT
TAAATGTATACATTATCTGAAACTTACAAAATATACACTGTTTCAAACAAGCATTGTTGGAAACTAAATCCATTATTTTAAATGTGGACT
ATTTAAACATGTAGAAAACAAAATTATAGACATAAACTATGATTTTAAAAATATTAACAATTTGCTAAATTTGCTTCAATGGGCAAGAGA
TCAATCCTACTTTTCATTGTTATTTTTAATATCATATTTTTCCCCAACATAATGTTATTATGAAGAGTATCAGATGTACAAATAAGCATC
ATTGGTAAAAACATACATGCTTCTTTGGCCAACATAATTTGTAACTGTCTTACTGAACCTACTTACCTACTATATTTTTTTTCCTCACTA
GTAGCATCTGATGGTTGATACAGTCAGTAACTATTCTGAAGAATCAGATTAAGAGAGAACAATTTACTTATTCAGGAATAAGTGCATTTT
TACAGTACATATTTTTCACATTTCAGCTGCAACTTCCAAAGATCAGGTTCTCATTGCTCCGTAGCACAGATTAAACAGCCTACTTATGTC
ATATCCTCACTTCACACCAACTTCTTCAGTCTATTATTTTAGTTTTCTAAATGTAGATCTAGTTTTCAACTGAATTCTTTGAGGATCGCA
ATCACACACAAAATAACATCCAAACTCCTCAACATGGAAGACTGGTGTCTTCACAATTAGATCATGGACAACACCATGACCCAGGCCCCT
GTGGCTGGTGAGACTTCTGGGCCCTGGGTACCACAGACTATACTCTAAACATGGTCTTTACTATCTCAGATCCTGCCCTGAGTGTCCTTT
GCAGCATGTTGAGTATTAGCCATTTTCAATGTCCAGTTCAAGTGCCATTGCTGGTAAGGCTTCTGTAGTTCTTATTGGAAGAATTGTCAC
TCTATGTCCCAGTAATAGTACTAATTTGGTTTCTTATTTTAACATATCATTTAGGAATCATACCATAGTTTGCATAATGGTTAATTTTAT
GCCTGCTTCTTCTATTATTTACAAATCCCTTTAGTTTGGGCTGTGAAATATTCAATTCCCAAAACATCACCCAATATCTATATGTTAAAG
GCTTGTTGAATTGTATTCCATCTATTAGTTCAGAGTTATTTGCTATTCTTGTTTAAGGACAATGTATGTATTAAAGAGCAACTAAAAACT
CCCATTACTGTTTGCCAACCCAGTTGTCTTTTGATTTCTCTGTCAACTTACAAGTATCAAATATCTAAGTCACAGAACCCAGAGACACAT
CAAATACCCCAAATACCCCATGGTAGTTTTCGGATGAACTCTGACAGCTATTGGCCATTTCTGGTGCAAGTCAGAAAAAAATTGCTTTTA
GTGTGAAATTTTTGATGCTGAAGAAAGTTGATTGTATTGAAGAGACACTGGCCCTTTATGATAAAGGAAGTCAAGTTTACAGTTTTGATA
TTTGTTTACTTTCTTATTTCTAATTTTTGGAAAACAATTTTCTTAGACTTTCATTTGTGATATTGATCATTTCTGTGTGTTTTAATCTTT
CTACATAACATAATTAAACACCTCAGTAGGTATCTAGTGAACTGATACAATAATGAGCTGAGTCATTTGTACAGAAATATAGTAGCTTCC
ATAATCTGAATGATAACCATTTAAAAGTGATGGTTGTTGAAATTTTACTGTAGTGTCAAATTTCACTTTAAATTTTGCAAAGCACCTGCT
ATTCTAGCCTTAACACAAAGATTTGGCTAATTTTTAAATGAACAAATCCCATTGAATATTAAGTGACACTGACAATCACCCTGAAAAGTA
TTCAGCCAAAGTTTCAATAGAATTAGGAAACTTAAATGAAAATGTGCTCTCAGTGCTTGGCCCATGAGCAGTTTATGATTTAAGACGTGC
ATACTGTTTAACTCTTTCCTTTAAAGTTCAGAAAAGTACATAAAACCTCTGGCTGACCTATTATATAGGCACAGAATTATCAAAAGCAAT
CAAAGTATGTACCTAAAGTCAATTTAGTATATTATGAATACAGCCTGATGACTAAACACAATTGCAAATATTGCGACTTTAGTTTTTAAT
TCAATTTTCAGCAAGTAGAAATATTTCTCAATTTTATTTGGTATCTAATTATATTAAGACCAACATATACATTAAAGTGTATTTAGATGA
TTAATATTTAATGATCATTATTTTATTTAATGATTAATATTTTCTATTATTTGAATTTCTGTAATTTATGTTTTAGAAAGAACTGTTTCC
AAACACATTTTATGGAAAGATTTCATTTTTCCATTCCCTTTACTTTTATATTTACATTGTCAAATAAATACAATTCTATTTTCATTTCTA
TTAGTTTTCAGGGTTTATTCTTTTCCTAAGCATATAATTCTTATAATGGAAAAAAGTGAAAAGTATCCAGTAAGTAATATACACCTATGA
AACTATTAATGTTCTTTATACTACCAAGTAGTTTCATAGTTTTAAAAAGCCATTCTTAAGCAGTCGGTGAATGTATATCATCGGCCAAAA
GTTATGCTAGGTTTCCTTCACTTATTATCACATTTAACCTCACAGTTCTCCCAAATTGTGGGTAATGCTATCCCCTTTGTTGCAGAAAAG
TAAATATAGGCTCAGGGAAATTTAAAAACTGCCTTAAGATTCAGTCTAGTGAATGAGAGGCTGAGTTAAGAATCCAAATCTGCTTTATAT
CAGAGCCCGTGATTTGAAGTCTTATCATTTGTGTTTAGGTCAGGGACCTCTAGAAAATAGACAGAAATTTCCAAAATGGTCTTTTACCCC
ACTCCCCATAAATAAGATAATGAATAGCAACACTGATCCCTAATTCTAGAATATCAATCTTGATACTTGTCAAAGTAAATAGTAGCTCGT
CACAAAAATGTTGTAGCCTCCCTAGTCTAAATGCTTATGCTATATTTTGTTTCCTAAATCTAGAGATCTCTTTTTAAAAATAGTATTGAA
GCATCAGGTTGTTCAGGTATGATTCTCATATTGAAATTTACAAAATATAACCAAATATTGTGACCCAGTTTTTCTGGAGCCAAGAGAAGT
AAACTGCCATTTATTAGGTGATGATTATAGGGCAAACACTACAATTTCAAATTTCATATTCTTTTATCTGATTTATTCATTTTATCAACT
CTGCTATATTGATGAAGAAGTCAACATATGGTGGGTAACTTATCCAAATTTCAGTGATGGGCTGGGCGTGGTGGCTCACGCCTATAATCC
CAGCACTTTGGGAGGCTGAGGCAGGTGGATCAGGAGTTTGAGGCCAACCTGACCAACATGTGAAACCCCATCTCTACTAAAAATACAAAA
AAATTACCTGGGCATGGTGGCACATGCCTGTAATCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTAAACCGAGGGGGTGGAGGTTGCTT
GAGCCGAGATCGCGTCACTGCACTCCAGCCTGGGTAACAGAGCAAGACTCTGTTTAAAAAAAAAAAAAAAATCAGTGATGGAACTGAGGC
CAAATCTGTCTGGTTCCAAAGCTATCCTACATGGGGCACAGTCAGGACTGGAATGGATAGCTCTACCTGCTTCCAAATATTCTTCCCTGG
GGAGCAGCTGTGAGTCTTACTGAATCGATTTATTCATTGCATTCTATGTGTCAACTGCAATTTAGACCTGGGTGATAGAGTCATATATGG
TCTTTGGACCCATGAAGCTCTGAGTCAAGGATACCAGCAGATATCCTTAAACTAATAAAAAAAGCGATGGCATCACATGCCATTTTGAAC
TTTTGCATTAAAGTCATAAACTTACATCAGTATTATGATTTATACTTTTAAGCAAAATTTTGCCATTTTCTGATACATAGTAGCTAGCTA
GTGATAAAATTATGAAGTTACCATTGTATGTTCCAATGACATAAAAAACTAAGTGCCTGCTTGGGCTAGTTATACTCTGCAGTATACCCT
GGTTTATTGTGAGGATTAAATAAAAAATCCTCACAAACCCCAATTTAATTTAATATAGATTAATTATAAAAATAATCTACCCATGTTACA
TAATGTTAAATCTGTAGTTTCAAGGTGTATGCTATTTCTTAAAACAAAAACAAAGATTGTCCCCACTCCAAACAATAACAGCAATGGTGA
AGGTTGTGGGTGGACAGAGGTAGTCCCACTCATCCCCAGGGGGCTCAGCTGCCACCGGCCAGGTCTATCTATTGCTCCCACCTGCTCTGA
CTGTTTTCTCTCAAGAAAAAGATTTTCATTTTAAGATAGGCATCAGTGCAATAAAGGAGCTTGATACAAAAATCATTATGTTCTATATAT
GTTTTTGTAGGTTTTAGATTAATTATGGCCAACTGATACCTTAAAATATTTGTTACAAATAACACTGAAGTGAGATTCAAAATTGTGCCT
TCTATTGAAGCCAAGAAAGTAAATGTCTTTAAAATAAACATAATGGTGTTTTTTTTTGGTACAATAAACAGCATACCTACATTTCAGAGG
ACAAATCATGTTATTATAATAACCAGGAGAGAAAATAAAAGGAGACATTAATTTGGATATGGAAGCAAAATGGAACAGAGCAATATAGAG
CAAAACAGAGGTTTGTCTGAAACATTTAAAATATTAAGAAGTATGACTAAAAAACTCAAACATTTTAATACACGATGAATCCTTTTCTTA
AGGAAAAAATGAAAATAATAAAAGTGGTATTTGGATGAGATAATTTTCCTTTAAATTTATTCCTCAGAATGATGTAAATTTTCCAGCTGG
AAGGTCATCTTTCTATACATGCATGCATCTATACAAATGGTTAAACAGTTACTCTCTCAATTTGCTGTGATAGGAAAGGTGGATATAAAT
ATAAGCAAGGGTCTGATTAAAACAAAACAAAACAAACAAAAGACAAGAGAAGCACTGCATTGTTGGCAAGAAATTCCTTTTAAGTCAGAC
TTAAGTCCACGGAAAGCTGGACCTAAGCAGTGAAGGATGTAAGGGAACAGAGAGAGACTCTGCTTGGCCGAGTTTGCTATTCTCATTTGT
CTATGTCAATACGGCTACATAAAGTTCACAACTATTTGCACATAGCTATAAATATAGCATGAATAAAACACATATGTATTTAATTGTGTT
ATTTACTATTTATAATTTGAATTGTTTAAAATAATTTTAAATACTTATTCCATAAACTCAGTATTTGAAAACTTAAAAAAAAAGTCATTT
TAAATAACATCATTTACCAAGTCTGTGTGATGCTTTACAAGGTACCTGATGAATGTAAAATTATAGCTTTTTGTCTTCATTTCTAATAGA
CTGTTATAGGGGAAATGTACTAAAATGTTGTACTTATTACATTTATGAATTTCTGACAGTTTCTATAGACTGAGAATAATGATATGCTTT
TATAAATTATTTGGTGAAAGTTTTCCAGTAAGTGTTCATGTCCTGTACAAATTTATTAAACAACATCAATTTTACCTAACAACTGTAACC
ACTAATAAATCATCAGTCACCACCTTTCCTGCATATCTGACAGATGGAGAACACTGTGCTTAGTGTTGAAGATACCAAAGGGAATTCAAG
TGAGGGGAAAAGAGGAGAGCAAACTGATCAAAAGGGAATGCCCATGATGCTTTCAGGAAACCAGGGTGAGAACATGCTGGCTGGAGGATG
GGTCTGGTTTCCAGCAGAGATGATAGGAGTTAAAAGGCATAGGTGAGTTGTTCCCATCCCTGGCCTGAGCCTTACTCCATAGCTATAGAG
ACATAGTCTCTAGAAACAAAGGCCAGAGCATCCTTTTAACATTTATATCATAAGTATTCTCAATAAACGTTTGCAATTTATTTGCTTTAA
TGTAACTTGGCAGTAAAGACTTTGGCCTTTGGAGGTCTGATTCTAATCCCAGTTCTACCACTTACTGGTTATTTATCAGGTACACGTTAC
CTACCTCTCTGTAACTCAGATTGCTCATCAGTAACATGGGGAGAGTGGTATCAACCACTAAGAGGATTAAATGAGTGAATATTTGTAAAA
CACGTAGCCTAGAATAGATATTTATAAAGCACAAGATCTATGTAAAGTGTTTATAACATAATACATTGGAATATGAGACTTGAACATTTT
GAAGATTCTAATAAATGAATAATTTAATTTAGTGCTCATTTGAAAAATATTTTATCCTCATGTTTACATTTAACACATATAATTTATATC
TTAGTTTTTATCCCATTTATATATATATTTACCAGAAAAATGTTTTGTAATACCTTAATTTTATGTGGAGTTGAATTTAAATAATTAGGC

>50811_50811_1_MAGI2-VWC2_MAGI2_chr7_79082336_ENST00000354212_VWC2_chr7_49842307_ENST00000340652_length(amino acids)=126AA_BP=
MASQRHLSHGDTLLDTLEPEGVLAVFDHGQHVPDGEPRHGGLVHLQQQLLRHQFAAALIGHLAGLHLPQVGELSILGAPLQFKAQLALRV

--------------------------------------------------------------
>50811_50811_2_MAGI2-VWC2_MAGI2_chr7_79082336_ENST00000419488_VWC2_chr7_49842307_ENST00000340652_length(transcript)=10583nt_BP=536nt
GGGACAGCACAACCTCATCCAAGCTCTCCTACCTCTGCCCAGCCGTCCCTCTCATCCTCCCCATTCCTCGTCCACACTCCATCCAAAGAA
GAGGGAAAGCACCGAATAGAGGGGGGCGAAGGCAAAGTCTGCTGTTCTTCCCCCTGGGCCCCCTTGCTCCTCCATCCTCATTCTCTCACC
ACCAGCCCCCCTAACCCCAAGGAGCCCAGGAACTGAGGCGACTCGCCCCACTGCCATGTCCAAAAGCTTGAAAAAGAAAAGCCACTGGAC
TAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTTGAACTGAAGGGGGGCGCCGAGAATGGACAGTTCCC
CTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTGGTGTCGGAGGAGCTGCTGCTGGAGGTGAACGAGAC
CCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAGGACCCCCTCCGGCTCAAGTGTGTCAAGCAAGGTGT
CTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTCAGCGTGTCCCCAGACGGAGTGTGTGGACCCTGTGT
ACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCTGCTGGCAGAGAAGTGAAGA
CTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGAGCGGCAGGCCATGTGCACGAGACATGAATGCAGGC
AAATGTAGACGCTTCCCAGAACACAAACTCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGATGACTCTGGGAACTATCAG
TCAAAGAAGACTTTTGATGAGGAATAATGGAAAATTGTTGGTACTTTTCCTTTTCTTGATAACAGTTACTACAACAGAAGGAAATGGATA
TATTTCAAAACATCAACAAGAACTTTGGGCATAAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAAGTACACAAAAGTACACTAT
TATATATCAAATGTATTTCTATAATCCCTCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGATTAAAAATGCTGTGTTGTCAA
CCGTCCTCACCGTGTACCTGCATATCTTTTTCAGTTCTGATTCCATCACCCAGGAATGTTCCCCCTGCACATTTTCACAGGGCAGAGTCA
CGCATGAATGGATCATAAGATATTAGGACCAATTTCCACTGAAACCCTGTTTAAATTCTATTTAATTACAGACATATCTCTAATGTTGAT
GTCTACTTCACATAAATATATTTCCTTTTTATAATAATATATGGCTTTTATCTGCTTCATTCTCAGTCACTTGTGAAATGCAGGTGTAAA
GATCACTAACTCACACTTTCTCAGTTCTTTCCCCTAAGCTCCTGTATTGTACACCATAGGTAAGCACATACATATATTTCATTCTTATTT
ACATTATTTTCTCTTCTAAGGATAACTTTAATTCATTCCCTAAACTGAGGAATAAAGTAGGCTGGAAAATTTGCATTACTGTTCCATCAA
GCTGAAGCAGACAACAAAATAGGGGAGGAGTCCTTCGATTCTCCTAGGATAGTTAAGGAAAATCAAACTCCTAAACAAGTTTATATACCT
GAAATCTAAATGTGCTACAGATAACTCAGCTGTCAGTTCAGTGGAATCATATTTGTCATCAGACTTGAGTCATCTATCCTCCATAAACTA
CACAGTAAAATCTTGACTGATAACCTTGAATTAGCCACCCTTCACAAGCAGAGTGAGGAAGCAGTTATTTTGTTAAAACAAAGCTGAAGA
CCAAGTGCACTCCACAACTTTCCTATAGTTATAATTCCAAACCAACTTCTTTTCTCTTCATTTGAACAGAGAACATAAAAAGCCACTGCA
AAGTCCTGCTAATCTAATTAATGCATAATAGAAAATAGTTCTACCTTTATCAATCATATCAGCATGCGGTGTGTTGATGAAAGAGGTAAT
TGGAGTCTTAATAGGTGTAGGATAAAAAAAGCAAAACTATAATCACTATTAATGTCTTTAAAGGATTAAAATATATATAATCATTATTTG
AAGCCTCTAAAGGTATTTTTCATATTTTTGTTTATTCTGAAATTTTGCATTAAGAACCTATTAAGTACAAAGCATTGACAACAAGGGAAT
AAGGCTTGATTTCTTGCCTTCTTGGACTTTCGGTCTCTGGCATAAGAAGTATATGAAATCATAATGTATTGTATTAGGAGCCAAACTAGA
GACCAGCAAATGGAGATTAGAAAGCCTTCCTAATGAGAAGATGGAGAACATGAAAAAATCATTATATAAAAAATAATTCAATCATTAAAG
ACTGAATAACATTCAAGAAAAATGGATACATCTATCATAATTGAAAAATTAAACTATTGTGAACCTTAGTAAGTATAAAGATGCCACTGA
CTGAGTCATCAAAACACTACATATAGTCATTTAATTTTTGTCTTGTTCATAAAGAACACCTTGAGCCAAAGGAACTACCAGTACATAGAT
TTCATGAAAATACTCAGGGGAATTATTAGCTAATTGTTCTCAGGTGTAATCAGCTTTCCAAAATTTAACCTTTGTATTAAAGACTGGTAG
ACATTGGCCATCCCTCCTTTATTCAAGGATGGATTGTTTGAGACACAGTTATTTAAAGTTGTCGTTTTGCTAATAAATGGCCCTAGCCCC
CATGGGTAGGTGGGCCATTAGTAACCTCTTCTCTCTCCATCAGGCATGATGCAGTTAGAGACTCAGTCCATGCAGCTCAAAGTCTTCCTG
TTTCCCTTAATAATAATTCCTACCAGAATGGATGATGAGCTCTGAAATAATTGCAATGGTGTTTTCAATGCTGTGAGAATTTCAGAAAAC
CTAGTATTTTGTTGCATATAGAGAGAATGAACCCAGTATCATCTTGGGAAGTTAACTGACTCACTTGCTCTAAACTTAGTTTGACCTGCA
GGGTCACCAGCACACACTCCTAAGAGCTAAAGCTCAATGGCTGTTATTACACCAAAGTAACTCCCCTCCCCATCTCTGATTTCAACCCCC
TCATTCCTCTCTCCTCATAGAAATAATGCATAAACCAAACACATGGAAGAACTTGGATTTTTGACACTGTATATACTCATTAATAATAAT
GGCATTATTTGCATTTTTGTCCAAGATCAACTTCTTCTTGCAGTTAGACTTTCACAAATACATAGCTATCTCAGATTGACATTCTATTTT
CCTCCCCTCTGTTGTCAGAGAACTCTTTGCTGAGATTGTCAACAACAAACTGTTCTATTCAATAAATAACCTGAATAACTGCCCAATAAA
AAAGGAAAGTATAAGTTACTCAATTTCAAAATAATATGGTTTGGAGATAGCACAGAAAAGGGGGCCTCAGAATTCAAGTATAGAAGTTCT
GGAAAAGCCATAATCACTAAAATTCAAATAGGCCTGCTCTATAAGTACCTAATAATTGTTAAATGATTTGTTCAAGTTAATAAACTAAAT
CGTGCTTACAAATGTATTAATGAATTTATTTCAAATTTTCAACCCATATTTAGATCTGAAAGTATAAAGCTACTTATGTAAGCAATAGAA
TGGTTCTGGAAATTATCTGATGTCTTAGAGGTTTTCAAGTTAAATTCATTCTTTCAGTGATAGGATATTTACTTGTTGGGTGGATTAACA
ATACTTTTTATTGACATTTCCCAGAAGTCTTGAGAAAAGTCATTTCAAAAACTTGTATTTCATCCCTGCATGCAAGAAGTATTAGATGCA
CTCCAGTCCAGGCAAGTCCTGCTATAATGTTGCAGCTAGTGCAGATGGAGAGGCACAGTGTCCTTGACATCAAGGGGTCTGTAAGCCTTG
AAACTAATTTAGGTTTGATTATAATACTTTTAATCTTTTGATACTTAGAATTTCATCACCTGCTTTGTGCAGTAAAACATGCTAAGAAGA
ATTATCATGCAGTTTTAAGTTCATAACATCAATAATATGTTTAATAAACTTTCTTCCCTCGTTCTCCAACATAAATGTTGCATTTATATA
AGGTTAAAAGTCCTAAAAAATCATAAAATTCAGATGTTTAATTTTTGTTTTTAAGCAGTGAAATGGGTTTTTAAATGTATACATTATCTG
AAACTTACAAAATATACACTGTTTCAAACAAGCATTGTTGGAAACTAAATCCATTATTTTAAATGTGGACTATTTAAACATGTAGAAAAC
AAAATTATAGACATAAACTATGATTTTAAAAATATTAACAATTTGCTAAATTTGCTTCAATGGGCAAGAGATCAATCCTACTTTTCATTG
TTATTTTTAATATCATATTTTTCCCCAACATAATGTTATTATGAAGAGTATCAGATGTACAAATAAGCATCATTGGTAAAAACATACATG
CTTCTTTGGCCAACATAATTTGTAACTGTCTTACTGAACCTACTTACCTACTATATTTTTTTTCCTCACTAGTAGCATCTGATGGTTGAT
ACAGTCAGTAACTATTCTGAAGAATCAGATTAAGAGAGAACAATTTACTTATTCAGGAATAAGTGCATTTTTACAGTACATATTTTTCAC
ATTTCAGCTGCAACTTCCAAAGATCAGGTTCTCATTGCTCCGTAGCACAGATTAAACAGCCTACTTATGTCATATCCTCACTTCACACCA
ACTTCTTCAGTCTATTATTTTAGTTTTCTAAATGTAGATCTAGTTTTCAACTGAATTCTTTGAGGATCGCAATCACACACAAAATAACAT
CCAAACTCCTCAACATGGAAGACTGGTGTCTTCACAATTAGATCATGGACAACACCATGACCCAGGCCCCTGTGGCTGGTGAGACTTCTG
GGCCCTGGGTACCACAGACTATACTCTAAACATGGTCTTTACTATCTCAGATCCTGCCCTGAGTGTCCTTTGCAGCATGTTGAGTATTAG
CCATTTTCAATGTCCAGTTCAAGTGCCATTGCTGGTAAGGCTTCTGTAGTTCTTATTGGAAGAATTGTCACTCTATGTCCCAGTAATAGT
ACTAATTTGGTTTCTTATTTTAACATATCATTTAGGAATCATACCATAGTTTGCATAATGGTTAATTTTATGCCTGCTTCTTCTATTATT
TACAAATCCCTTTAGTTTGGGCTGTGAAATATTCAATTCCCAAAACATCACCCAATATCTATATGTTAAAGGCTTGTTGAATTGTATTCC
ATCTATTAGTTCAGAGTTATTTGCTATTCTTGTTTAAGGACAATGTATGTATTAAAGAGCAACTAAAAACTCCCATTACTGTTTGCCAAC
CCAGTTGTCTTTTGATTTCTCTGTCAACTTACAAGTATCAAATATCTAAGTCACAGAACCCAGAGACACATCAAATACCCCAAATACCCC
ATGGTAGTTTTCGGATGAACTCTGACAGCTATTGGCCATTTCTGGTGCAAGTCAGAAAAAAATTGCTTTTAGTGTGAAATTTTTGATGCT
GAAGAAAGTTGATTGTATTGAAGAGACACTGGCCCTTTATGATAAAGGAAGTCAAGTTTACAGTTTTGATATTTGTTTACTTTCTTATTT
CTAATTTTTGGAAAACAATTTTCTTAGACTTTCATTTGTGATATTGATCATTTCTGTGTGTTTTAATCTTTCTACATAACATAATTAAAC
ACCTCAGTAGGTATCTAGTGAACTGATACAATAATGAGCTGAGTCATTTGTACAGAAATATAGTAGCTTCCATAATCTGAATGATAACCA
TTTAAAAGTGATGGTTGTTGAAATTTTACTGTAGTGTCAAATTTCACTTTAAATTTTGCAAAGCACCTGCTATTCTAGCCTTAACACAAA
GATTTGGCTAATTTTTAAATGAACAAATCCCATTGAATATTAAGTGACACTGACAATCACCCTGAAAAGTATTCAGCCAAAGTTTCAATA
GAATTAGGAAACTTAAATGAAAATGTGCTCTCAGTGCTTGGCCCATGAGCAGTTTATGATTTAAGACGTGCATACTGTTTAACTCTTTCC
TTTAAAGTTCAGAAAAGTACATAAAACCTCTGGCTGACCTATTATATAGGCACAGAATTATCAAAAGCAATCAAAGTATGTACCTAAAGT
CAATTTAGTATATTATGAATACAGCCTGATGACTAAACACAATTGCAAATATTGCGACTTTAGTTTTTAATTCAATTTTCAGCAAGTAGA
AATATTTCTCAATTTTATTTGGTATCTAATTATATTAAGACCAACATATACATTAAAGTGTATTTAGATGATTAATATTTAATGATCATT
ATTTTATTTAATGATTAATATTTTCTATTATTTGAATTTCTGTAATTTATGTTTTAGAAAGAACTGTTTCCAAACACATTTTATGGAAAG
ATTTCATTTTTCCATTCCCTTTACTTTTATATTTACATTGTCAAATAAATACAATTCTATTTTCATTTCTATTAGTTTTCAGGGTTTATT
CTTTTCCTAAGCATATAATTCTTATAATGGAAAAAAGTGAAAAGTATCCAGTAAGTAATATACACCTATGAAACTATTAATGTTCTTTAT
ACTACCAAGTAGTTTCATAGTTTTAAAAAGCCATTCTTAAGCAGTCGGTGAATGTATATCATCGGCCAAAAGTTATGCTAGGTTTCCTTC
ACTTATTATCACATTTAACCTCACAGTTCTCCCAAATTGTGGGTAATGCTATCCCCTTTGTTGCAGAAAAGTAAATATAGGCTCAGGGAA
ATTTAAAAACTGCCTTAAGATTCAGTCTAGTGAATGAGAGGCTGAGTTAAGAATCCAAATCTGCTTTATATCAGAGCCCGTGATTTGAAG
TCTTATCATTTGTGTTTAGGTCAGGGACCTCTAGAAAATAGACAGAAATTTCCAAAATGGTCTTTTACCCCACTCCCCATAAATAAGATA
ATGAATAGCAACACTGATCCCTAATTCTAGAATATCAATCTTGATACTTGTCAAAGTAAATAGTAGCTCGTCACAAAAATGTTGTAGCCT
CCCTAGTCTAAATGCTTATGCTATATTTTGTTTCCTAAATCTAGAGATCTCTTTTTAAAAATAGTATTGAAGCATCAGGTTGTTCAGGTA
TGATTCTCATATTGAAATTTACAAAATATAACCAAATATTGTGACCCAGTTTTTCTGGAGCCAAGAGAAGTAAACTGCCATTTATTAGGT
GATGATTATAGGGCAAACACTACAATTTCAAATTTCATATTCTTTTATCTGATTTATTCATTTTATCAACTCTGCTATATTGATGAAGAA
GTCAACATATGGTGGGTAACTTATCCAAATTTCAGTGATGGGCTGGGCGTGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGA
GGCAGGTGGATCAGGAGTTTGAGGCCAACCTGACCAACATGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTACCTGGGCATGGTG
GCACATGCCTGTAATCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTAAACCGAGGGGGTGGAGGTTGCTTGAGCCGAGATCGCGTCACT
GCACTCCAGCCTGGGTAACAGAGCAAGACTCTGTTTAAAAAAAAAAAAAAAATCAGTGATGGAACTGAGGCCAAATCTGTCTGGTTCCAA
AGCTATCCTACATGGGGCACAGTCAGGACTGGAATGGATAGCTCTACCTGCTTCCAAATATTCTTCCCTGGGGAGCAGCTGTGAGTCTTA
CTGAATCGATTTATTCATTGCATTCTATGTGTCAACTGCAATTTAGACCTGGGTGATAGAGTCATATATGGTCTTTGGACCCATGAAGCT
CTGAGTCAAGGATACCAGCAGATATCCTTAAACTAATAAAAAAAGCGATGGCATCACATGCCATTTTGAACTTTTGCATTAAAGTCATAA
ACTTACATCAGTATTATGATTTATACTTTTAAGCAAAATTTTGCCATTTTCTGATACATAGTAGCTAGCTAGTGATAAAATTATGAAGTT
ACCATTGTATGTTCCAATGACATAAAAAACTAAGTGCCTGCTTGGGCTAGTTATACTCTGCAGTATACCCTGGTTTATTGTGAGGATTAA
ATAAAAAATCCTCACAAACCCCAATTTAATTTAATATAGATTAATTATAAAAATAATCTACCCATGTTACATAATGTTAAATCTGTAGTT
TCAAGGTGTATGCTATTTCTTAAAACAAAAACAAAGATTGTCCCCACTCCAAACAATAACAGCAATGGTGAAGGTTGTGGGTGGACAGAG
GTAGTCCCACTCATCCCCAGGGGGCTCAGCTGCCACCGGCCAGGTCTATCTATTGCTCCCACCTGCTCTGACTGTTTTCTCTCAAGAAAA
AGATTTTCATTTTAAGATAGGCATCAGTGCAATAAAGGAGCTTGATACAAAAATCATTATGTTCTATATATGTTTTTGTAGGTTTTAGAT
TAATTATGGCCAACTGATACCTTAAAATATTTGTTACAAATAACACTGAAGTGAGATTCAAAATTGTGCCTTCTATTGAAGCCAAGAAAG
TAAATGTCTTTAAAATAAACATAATGGTGTTTTTTTTTGGTACAATAAACAGCATACCTACATTTCAGAGGACAAATCATGTTATTATAA
TAACCAGGAGAGAAAATAAAAGGAGACATTAATTTGGATATGGAAGCAAAATGGAACAGAGCAATATAGAGCAAAACAGAGGTTTGTCTG
AAACATTTAAAATATTAAGAAGTATGACTAAAAAACTCAAACATTTTAATACACGATGAATCCTTTTCTTAAGGAAAAAATGAAAATAAT
AAAAGTGGTATTTGGATGAGATAATTTTCCTTTAAATTTATTCCTCAGAATGATGTAAATTTTCCAGCTGGAAGGTCATCTTTCTATACA
TGCATGCATCTATACAAATGGTTAAACAGTTACTCTCTCAATTTGCTGTGATAGGAAAGGTGGATATAAATATAAGCAAGGGTCTGATTA
AAACAAAACAAAACAAACAAAAGACAAGAGAAGCACTGCATTGTTGGCAAGAAATTCCTTTTAAGTCAGACTTAAGTCCACGGAAAGCTG
GACCTAAGCAGTGAAGGATGTAAGGGAACAGAGAGAGACTCTGCTTGGCCGAGTTTGCTATTCTCATTTGTCTATGTCAATACGGCTACA
TAAAGTTCACAACTATTTGCACATAGCTATAAATATAGCATGAATAAAACACATATGTATTTAATTGTGTTATTTACTATTTATAATTTG
AATTGTTTAAAATAATTTTAAATACTTATTCCATAAACTCAGTATTTGAAAACTTAAAAAAAAAGTCATTTTAAATAACATCATTTACCA
AGTCTGTGTGATGCTTTACAAGGTACCTGATGAATGTAAAATTATAGCTTTTTGTCTTCATTTCTAATAGACTGTTATAGGGGAAATGTA
CTAAAATGTTGTACTTATTACATTTATGAATTTCTGACAGTTTCTATAGACTGAGAATAATGATATGCTTTTATAAATTATTTGGTGAAA
GTTTTCCAGTAAGTGTTCATGTCCTGTACAAATTTATTAAACAACATCAATTTTACCTAACAACTGTAACCACTAATAAATCATCAGTCA
CCACCTTTCCTGCATATCTGACAGATGGAGAACACTGTGCTTAGTGTTGAAGATACCAAAGGGAATTCAAGTGAGGGGAAAAGAGGAGAG
CAAACTGATCAAAAGGGAATGCCCATGATGCTTTCAGGAAACCAGGGTGAGAACATGCTGGCTGGAGGATGGGTCTGGTTTCCAGCAGAG
ATGATAGGAGTTAAAAGGCATAGGTGAGTTGTTCCCATCCCTGGCCTGAGCCTTACTCCATAGCTATAGAGACATAGTCTCTAGAAACAA
AGGCCAGAGCATCCTTTTAACATTTATATCATAAGTATTCTCAATAAACGTTTGCAATTTATTTGCTTTAATGTAACTTGGCAGTAAAGA
CTTTGGCCTTTGGAGGTCTGATTCTAATCCCAGTTCTACCACTTACTGGTTATTTATCAGGTACACGTTACCTACCTCTCTGTAACTCAG
ATTGCTCATCAGTAACATGGGGAGAGTGGTATCAACCACTAAGAGGATTAAATGAGTGAATATTTGTAAAACACGTAGCCTAGAATAGAT
ATTTATAAAGCACAAGATCTATGTAAAGTGTTTATAACATAATACATTGGAATATGAGACTTGAACATTTTGAAGATTCTAATAAATGAA
TAATTTAATTTAGTGCTCATTTGAAAAATATTTTATCCTCATGTTTACATTTAACACATATAATTTATATCTTAGTTTTTATCCCATTTA
TATATATATTTACCAGAAAAATGTTTTGTAATACCTTAATTTTATGTGGAGTTGAATTTAAATAATTAGGCCGAATTTGTATGTATTGTT

>50811_50811_2_MAGI2-VWC2_MAGI2_chr7_79082336_ENST00000419488_VWC2_chr7_49842307_ENST00000340652_length(amino acids)=126AA_BP=
MASQRHLSHGDTLLDTLEPEGVLAVFDHGQHVPDGEPRHGGLVHLQQQLLRHQFAAALIGHLAGLHLPQVGELSILGAPLQFKAQLALRV

--------------------------------------------------------------
>50811_50811_3_MAGI2-VWC2_MAGI2_chr7_79082336_ENST00000522391_VWC2_chr7_49842307_ENST00000340652_length(transcript)=10498nt_BP=451nt
AAGAAGAGGGAAAGCACCGAATAGAGGGGGGCGAAGGCAAAGTCTGCTGTTCTTCCCCCTGGGCCCCCTTGCTCCTCCATCCTCATTCTC
TCACCACCAGCCCCCCTAACCCCAAGGAGCCCAGGAACTGAGGCGACTCGCCCCACTGCCATGTCCAAAAGCTTGAAAAAGAAAAGCCAC
TGGACTAGCAAAGTCCATGAGAGTGTCATTGGCAGGAACCCGGAGGGCCAGCTGGGCTTTGAACTGAAGGGGGGCGCCGAGAATGGACAG
TTCCCCTACCTGGGGGAGGTGAAGCCCGGCAAGGTGGCCTATGAGAGCGGCAGCAAATTGGTGTCGGAGGAGCTGCTGCTGGAGGTGAAC
GAGACCCCCGTGGCGGGGCTCACCATCAGGGACGTGCTGGCCGTGATCAAACACTGCAAGGACCCCCTCCGGCTCAAGTGTGTCAAGCAA
GGTGTCTCCATGCGAGAGGTGTCGCTGTGAAGCCAACGGTGAGGTGCTATGCACAGTGTCAGCGTGTCCCCAGACGGAGTGTGTGGACCC
TGTGTACGAGCCTGATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCTGCTGGCAGAGAAGT
GAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATGGAGAATCGAGCGGCAGGCCATGTGCACGAGACATGAATG
CAGGCAAATGTAGACGCTTCCCAGAACACAAACTCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGATGACTCTGGGAACT
ATCAGTCAAAGAAGACTTTTGATGAGGAATAATGGAAAATTGTTGGTACTTTTCCTTTTCTTGATAACAGTTACTACAACAGAAGGAAAT
GGATATATTTCAAAACATCAACAAGAACTTTGGGCATAAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAAGTACACAAAAGTAC
ACTATTATATATCAAATGTATTTCTATAATCCCTCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGATTAAAAATGCTGTGTT
GTCAACCGTCCTCACCGTGTACCTGCATATCTTTTTCAGTTCTGATTCCATCACCCAGGAATGTTCCCCCTGCACATTTTCACAGGGCAG
AGTCACGCATGAATGGATCATAAGATATTAGGACCAATTTCCACTGAAACCCTGTTTAAATTCTATTTAATTACAGACATATCTCTAATG
TTGATGTCTACTTCACATAAATATATTTCCTTTTTATAATAATATATGGCTTTTATCTGCTTCATTCTCAGTCACTTGTGAAATGCAGGT
GTAAAGATCACTAACTCACACTTTCTCAGTTCTTTCCCCTAAGCTCCTGTATTGTACACCATAGGTAAGCACATACATATATTTCATTCT
TATTTACATTATTTTCTCTTCTAAGGATAACTTTAATTCATTCCCTAAACTGAGGAATAAAGTAGGCTGGAAAATTTGCATTACTGTTCC
ATCAAGCTGAAGCAGACAACAAAATAGGGGAGGAGTCCTTCGATTCTCCTAGGATAGTTAAGGAAAATCAAACTCCTAAACAAGTTTATA
TACCTGAAATCTAAATGTGCTACAGATAACTCAGCTGTCAGTTCAGTGGAATCATATTTGTCATCAGACTTGAGTCATCTATCCTCCATA
AACTACACAGTAAAATCTTGACTGATAACCTTGAATTAGCCACCCTTCACAAGCAGAGTGAGGAAGCAGTTATTTTGTTAAAACAAAGCT
GAAGACCAAGTGCACTCCACAACTTTCCTATAGTTATAATTCCAAACCAACTTCTTTTCTCTTCATTTGAACAGAGAACATAAAAAGCCA
CTGCAAAGTCCTGCTAATCTAATTAATGCATAATAGAAAATAGTTCTACCTTTATCAATCATATCAGCATGCGGTGTGTTGATGAAAGAG
GTAATTGGAGTCTTAATAGGTGTAGGATAAAAAAAGCAAAACTATAATCACTATTAATGTCTTTAAAGGATTAAAATATATATAATCATT
ATTTGAAGCCTCTAAAGGTATTTTTCATATTTTTGTTTATTCTGAAATTTTGCATTAAGAACCTATTAAGTACAAAGCATTGACAACAAG
GGAATAAGGCTTGATTTCTTGCCTTCTTGGACTTTCGGTCTCTGGCATAAGAAGTATATGAAATCATAATGTATTGTATTAGGAGCCAAA
CTAGAGACCAGCAAATGGAGATTAGAAAGCCTTCCTAATGAGAAGATGGAGAACATGAAAAAATCATTATATAAAAAATAATTCAATCAT
TAAAGACTGAATAACATTCAAGAAAAATGGATACATCTATCATAATTGAAAAATTAAACTATTGTGAACCTTAGTAAGTATAAAGATGCC
ACTGACTGAGTCATCAAAACACTACATATAGTCATTTAATTTTTGTCTTGTTCATAAAGAACACCTTGAGCCAAAGGAACTACCAGTACA
TAGATTTCATGAAAATACTCAGGGGAATTATTAGCTAATTGTTCTCAGGTGTAATCAGCTTTCCAAAATTTAACCTTTGTATTAAAGACT
GGTAGACATTGGCCATCCCTCCTTTATTCAAGGATGGATTGTTTGAGACACAGTTATTTAAAGTTGTCGTTTTGCTAATAAATGGCCCTA
GCCCCCATGGGTAGGTGGGCCATTAGTAACCTCTTCTCTCTCCATCAGGCATGATGCAGTTAGAGACTCAGTCCATGCAGCTCAAAGTCT
TCCTGTTTCCCTTAATAATAATTCCTACCAGAATGGATGATGAGCTCTGAAATAATTGCAATGGTGTTTTCAATGCTGTGAGAATTTCAG
AAAACCTAGTATTTTGTTGCATATAGAGAGAATGAACCCAGTATCATCTTGGGAAGTTAACTGACTCACTTGCTCTAAACTTAGTTTGAC
CTGCAGGGTCACCAGCACACACTCCTAAGAGCTAAAGCTCAATGGCTGTTATTACACCAAAGTAACTCCCCTCCCCATCTCTGATTTCAA
CCCCCTCATTCCTCTCTCCTCATAGAAATAATGCATAAACCAAACACATGGAAGAACTTGGATTTTTGACACTGTATATACTCATTAATA
ATAATGGCATTATTTGCATTTTTGTCCAAGATCAACTTCTTCTTGCAGTTAGACTTTCACAAATACATAGCTATCTCAGATTGACATTCT
ATTTTCCTCCCCTCTGTTGTCAGAGAACTCTTTGCTGAGATTGTCAACAACAAACTGTTCTATTCAATAAATAACCTGAATAACTGCCCA
ATAAAAAAGGAAAGTATAAGTTACTCAATTTCAAAATAATATGGTTTGGAGATAGCACAGAAAAGGGGGCCTCAGAATTCAAGTATAGAA
GTTCTGGAAAAGCCATAATCACTAAAATTCAAATAGGCCTGCTCTATAAGTACCTAATAATTGTTAAATGATTTGTTCAAGTTAATAAAC
TAAATCGTGCTTACAAATGTATTAATGAATTTATTTCAAATTTTCAACCCATATTTAGATCTGAAAGTATAAAGCTACTTATGTAAGCAA
TAGAATGGTTCTGGAAATTATCTGATGTCTTAGAGGTTTTCAAGTTAAATTCATTCTTTCAGTGATAGGATATTTACTTGTTGGGTGGAT
TAACAATACTTTTTATTGACATTTCCCAGAAGTCTTGAGAAAAGTCATTTCAAAAACTTGTATTTCATCCCTGCATGCAAGAAGTATTAG
ATGCACTCCAGTCCAGGCAAGTCCTGCTATAATGTTGCAGCTAGTGCAGATGGAGAGGCACAGTGTCCTTGACATCAAGGGGTCTGTAAG
CCTTGAAACTAATTTAGGTTTGATTATAATACTTTTAATCTTTTGATACTTAGAATTTCATCACCTGCTTTGTGCAGTAAAACATGCTAA
GAAGAATTATCATGCAGTTTTAAGTTCATAACATCAATAATATGTTTAATAAACTTTCTTCCCTCGTTCTCCAACATAAATGTTGCATTT
ATATAAGGTTAAAAGTCCTAAAAAATCATAAAATTCAGATGTTTAATTTTTGTTTTTAAGCAGTGAAATGGGTTTTTAAATGTATACATT
ATCTGAAACTTACAAAATATACACTGTTTCAAACAAGCATTGTTGGAAACTAAATCCATTATTTTAAATGTGGACTATTTAAACATGTAG
AAAACAAAATTATAGACATAAACTATGATTTTAAAAATATTAACAATTTGCTAAATTTGCTTCAATGGGCAAGAGATCAATCCTACTTTT
CATTGTTATTTTTAATATCATATTTTTCCCCAACATAATGTTATTATGAAGAGTATCAGATGTACAAATAAGCATCATTGGTAAAAACAT
ACATGCTTCTTTGGCCAACATAATTTGTAACTGTCTTACTGAACCTACTTACCTACTATATTTTTTTTCCTCACTAGTAGCATCTGATGG
TTGATACAGTCAGTAACTATTCTGAAGAATCAGATTAAGAGAGAACAATTTACTTATTCAGGAATAAGTGCATTTTTACAGTACATATTT
TTCACATTTCAGCTGCAACTTCCAAAGATCAGGTTCTCATTGCTCCGTAGCACAGATTAAACAGCCTACTTATGTCATATCCTCACTTCA
CACCAACTTCTTCAGTCTATTATTTTAGTTTTCTAAATGTAGATCTAGTTTTCAACTGAATTCTTTGAGGATCGCAATCACACACAAAAT
AACATCCAAACTCCTCAACATGGAAGACTGGTGTCTTCACAATTAGATCATGGACAACACCATGACCCAGGCCCCTGTGGCTGGTGAGAC
TTCTGGGCCCTGGGTACCACAGACTATACTCTAAACATGGTCTTTACTATCTCAGATCCTGCCCTGAGTGTCCTTTGCAGCATGTTGAGT
ATTAGCCATTTTCAATGTCCAGTTCAAGTGCCATTGCTGGTAAGGCTTCTGTAGTTCTTATTGGAAGAATTGTCACTCTATGTCCCAGTA
ATAGTACTAATTTGGTTTCTTATTTTAACATATCATTTAGGAATCATACCATAGTTTGCATAATGGTTAATTTTATGCCTGCTTCTTCTA
TTATTTACAAATCCCTTTAGTTTGGGCTGTGAAATATTCAATTCCCAAAACATCACCCAATATCTATATGTTAAAGGCTTGTTGAATTGT
ATTCCATCTATTAGTTCAGAGTTATTTGCTATTCTTGTTTAAGGACAATGTATGTATTAAAGAGCAACTAAAAACTCCCATTACTGTTTG
CCAACCCAGTTGTCTTTTGATTTCTCTGTCAACTTACAAGTATCAAATATCTAAGTCACAGAACCCAGAGACACATCAAATACCCCAAAT
ACCCCATGGTAGTTTTCGGATGAACTCTGACAGCTATTGGCCATTTCTGGTGCAAGTCAGAAAAAAATTGCTTTTAGTGTGAAATTTTTG
ATGCTGAAGAAAGTTGATTGTATTGAAGAGACACTGGCCCTTTATGATAAAGGAAGTCAAGTTTACAGTTTTGATATTTGTTTACTTTCT
TATTTCTAATTTTTGGAAAACAATTTTCTTAGACTTTCATTTGTGATATTGATCATTTCTGTGTGTTTTAATCTTTCTACATAACATAAT
TAAACACCTCAGTAGGTATCTAGTGAACTGATACAATAATGAGCTGAGTCATTTGTACAGAAATATAGTAGCTTCCATAATCTGAATGAT
AACCATTTAAAAGTGATGGTTGTTGAAATTTTACTGTAGTGTCAAATTTCACTTTAAATTTTGCAAAGCACCTGCTATTCTAGCCTTAAC
ACAAAGATTTGGCTAATTTTTAAATGAACAAATCCCATTGAATATTAAGTGACACTGACAATCACCCTGAAAAGTATTCAGCCAAAGTTT
CAATAGAATTAGGAAACTTAAATGAAAATGTGCTCTCAGTGCTTGGCCCATGAGCAGTTTATGATTTAAGACGTGCATACTGTTTAACTC
TTTCCTTTAAAGTTCAGAAAAGTACATAAAACCTCTGGCTGACCTATTATATAGGCACAGAATTATCAAAAGCAATCAAAGTATGTACCT
AAAGTCAATTTAGTATATTATGAATACAGCCTGATGACTAAACACAATTGCAAATATTGCGACTTTAGTTTTTAATTCAATTTTCAGCAA
GTAGAAATATTTCTCAATTTTATTTGGTATCTAATTATATTAAGACCAACATATACATTAAAGTGTATTTAGATGATTAATATTTAATGA
TCATTATTTTATTTAATGATTAATATTTTCTATTATTTGAATTTCTGTAATTTATGTTTTAGAAAGAACTGTTTCCAAACACATTTTATG
GAAAGATTTCATTTTTCCATTCCCTTTACTTTTATATTTACATTGTCAAATAAATACAATTCTATTTTCATTTCTATTAGTTTTCAGGGT
TTATTCTTTTCCTAAGCATATAATTCTTATAATGGAAAAAAGTGAAAAGTATCCAGTAAGTAATATACACCTATGAAACTATTAATGTTC
TTTATACTACCAAGTAGTTTCATAGTTTTAAAAAGCCATTCTTAAGCAGTCGGTGAATGTATATCATCGGCCAAAAGTTATGCTAGGTTT
CCTTCACTTATTATCACATTTAACCTCACAGTTCTCCCAAATTGTGGGTAATGCTATCCCCTTTGTTGCAGAAAAGTAAATATAGGCTCA
GGGAAATTTAAAAACTGCCTTAAGATTCAGTCTAGTGAATGAGAGGCTGAGTTAAGAATCCAAATCTGCTTTATATCAGAGCCCGTGATT
TGAAGTCTTATCATTTGTGTTTAGGTCAGGGACCTCTAGAAAATAGACAGAAATTTCCAAAATGGTCTTTTACCCCACTCCCCATAAATA
AGATAATGAATAGCAACACTGATCCCTAATTCTAGAATATCAATCTTGATACTTGTCAAAGTAAATAGTAGCTCGTCACAAAAATGTTGT
AGCCTCCCTAGTCTAAATGCTTATGCTATATTTTGTTTCCTAAATCTAGAGATCTCTTTTTAAAAATAGTATTGAAGCATCAGGTTGTTC
AGGTATGATTCTCATATTGAAATTTACAAAATATAACCAAATATTGTGACCCAGTTTTTCTGGAGCCAAGAGAAGTAAACTGCCATTTAT
TAGGTGATGATTATAGGGCAAACACTACAATTTCAAATTTCATATTCTTTTATCTGATTTATTCATTTTATCAACTCTGCTATATTGATG
AAGAAGTCAACATATGGTGGGTAACTTATCCAAATTTCAGTGATGGGCTGGGCGTGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAG
GCTGAGGCAGGTGGATCAGGAGTTTGAGGCCAACCTGACCAACATGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTACCTGGGCA
TGGTGGCACATGCCTGTAATCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTAAACCGAGGGGGTGGAGGTTGCTTGAGCCGAGATCGCG
TCACTGCACTCCAGCCTGGGTAACAGAGCAAGACTCTGTTTAAAAAAAAAAAAAAAATCAGTGATGGAACTGAGGCCAAATCTGTCTGGT
TCCAAAGCTATCCTACATGGGGCACAGTCAGGACTGGAATGGATAGCTCTACCTGCTTCCAAATATTCTTCCCTGGGGAGCAGCTGTGAG
TCTTACTGAATCGATTTATTCATTGCATTCTATGTGTCAACTGCAATTTAGACCTGGGTGATAGAGTCATATATGGTCTTTGGACCCATG
AAGCTCTGAGTCAAGGATACCAGCAGATATCCTTAAACTAATAAAAAAAGCGATGGCATCACATGCCATTTTGAACTTTTGCATTAAAGT
CATAAACTTACATCAGTATTATGATTTATACTTTTAAGCAAAATTTTGCCATTTTCTGATACATAGTAGCTAGCTAGTGATAAAATTATG
AAGTTACCATTGTATGTTCCAATGACATAAAAAACTAAGTGCCTGCTTGGGCTAGTTATACTCTGCAGTATACCCTGGTTTATTGTGAGG
ATTAAATAAAAAATCCTCACAAACCCCAATTTAATTTAATATAGATTAATTATAAAAATAATCTACCCATGTTACATAATGTTAAATCTG
TAGTTTCAAGGTGTATGCTATTTCTTAAAACAAAAACAAAGATTGTCCCCACTCCAAACAATAACAGCAATGGTGAAGGTTGTGGGTGGA
CAGAGGTAGTCCCACTCATCCCCAGGGGGCTCAGCTGCCACCGGCCAGGTCTATCTATTGCTCCCACCTGCTCTGACTGTTTTCTCTCAA
GAAAAAGATTTTCATTTTAAGATAGGCATCAGTGCAATAAAGGAGCTTGATACAAAAATCATTATGTTCTATATATGTTTTTGTAGGTTT
TAGATTAATTATGGCCAACTGATACCTTAAAATATTTGTTACAAATAACACTGAAGTGAGATTCAAAATTGTGCCTTCTATTGAAGCCAA
GAAAGTAAATGTCTTTAAAATAAACATAATGGTGTTTTTTTTTGGTACAATAAACAGCATACCTACATTTCAGAGGACAAATCATGTTAT
TATAATAACCAGGAGAGAAAATAAAAGGAGACATTAATTTGGATATGGAAGCAAAATGGAACAGAGCAATATAGAGCAAAACAGAGGTTT
GTCTGAAACATTTAAAATATTAAGAAGTATGACTAAAAAACTCAAACATTTTAATACACGATGAATCCTTTTCTTAAGGAAAAAATGAAA
ATAATAAAAGTGGTATTTGGATGAGATAATTTTCCTTTAAATTTATTCCTCAGAATGATGTAAATTTTCCAGCTGGAAGGTCATCTTTCT
ATACATGCATGCATCTATACAAATGGTTAAACAGTTACTCTCTCAATTTGCTGTGATAGGAAAGGTGGATATAAATATAAGCAAGGGTCT
GATTAAAACAAAACAAAACAAACAAAAGACAAGAGAAGCACTGCATTGTTGGCAAGAAATTCCTTTTAAGTCAGACTTAAGTCCACGGAA
AGCTGGACCTAAGCAGTGAAGGATGTAAGGGAACAGAGAGAGACTCTGCTTGGCCGAGTTTGCTATTCTCATTTGTCTATGTCAATACGG
CTACATAAAGTTCACAACTATTTGCACATAGCTATAAATATAGCATGAATAAAACACATATGTATTTAATTGTGTTATTTACTATTTATA
ATTTGAATTGTTTAAAATAATTTTAAATACTTATTCCATAAACTCAGTATTTGAAAACTTAAAAAAAAAGTCATTTTAAATAACATCATT
TACCAAGTCTGTGTGATGCTTTACAAGGTACCTGATGAATGTAAAATTATAGCTTTTTGTCTTCATTTCTAATAGACTGTTATAGGGGAA
ATGTACTAAAATGTTGTACTTATTACATTTATGAATTTCTGACAGTTTCTATAGACTGAGAATAATGATATGCTTTTATAAATTATTTGG
TGAAAGTTTTCCAGTAAGTGTTCATGTCCTGTACAAATTTATTAAACAACATCAATTTTACCTAACAACTGTAACCACTAATAAATCATC
AGTCACCACCTTTCCTGCATATCTGACAGATGGAGAACACTGTGCTTAGTGTTGAAGATACCAAAGGGAATTCAAGTGAGGGGAAAAGAG
GAGAGCAAACTGATCAAAAGGGAATGCCCATGATGCTTTCAGGAAACCAGGGTGAGAACATGCTGGCTGGAGGATGGGTCTGGTTTCCAG
CAGAGATGATAGGAGTTAAAAGGCATAGGTGAGTTGTTCCCATCCCTGGCCTGAGCCTTACTCCATAGCTATAGAGACATAGTCTCTAGA
AACAAAGGCCAGAGCATCCTTTTAACATTTATATCATAAGTATTCTCAATAAACGTTTGCAATTTATTTGCTTTAATGTAACTTGGCAGT
AAAGACTTTGGCCTTTGGAGGTCTGATTCTAATCCCAGTTCTACCACTTACTGGTTATTTATCAGGTACACGTTACCTACCTCTCTGTAA
CTCAGATTGCTCATCAGTAACATGGGGAGAGTGGTATCAACCACTAAGAGGATTAAATGAGTGAATATTTGTAAAACACGTAGCCTAGAA
TAGATATTTATAAAGCACAAGATCTATGTAAAGTGTTTATAACATAATACATTGGAATATGAGACTTGAACATTTTGAAGATTCTAATAA
ATGAATAATTTAATTTAGTGCTCATTTGAAAAATATTTTATCCTCATGTTTACATTTAACACATATAATTTATATCTTAGTTTTTATCCC
ATTTATATATATATTTACCAGAAAAATGTTTTGTAATACCTTAATTTTATGTGGAGTTGAATTTAAATAATTAGGCCGAATTTGTATGTA

>50811_50811_3_MAGI2-VWC2_MAGI2_chr7_79082336_ENST00000522391_VWC2_chr7_49842307_ENST00000340652_length(amino acids)=126AA_BP=
MASQRHLSHGDTLLDTLEPEGVLAVFDHGQHVPDGEPRHGGLVHLQQQLLRHQFAAALIGHLAGLHLPQVGELSILGAPLQFKAQLALRV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MAGI2-VWC2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MAGI2	chr7:79082336	chr7:49842307	ENST00000354212	-	1	22	302_381	100.33333333333333	1456.0	DDN
Hgene	MAGI2	chr7:79082336	chr7:49842307	ENST00000419488	-	1	21	302_381	100.33333333333333	1442.0	DDN

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MAGI2-VWC2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MAGI2-VWC2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source