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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAGI3-MAGI3 (FusionGDB2 ID:50817)

Fusion Gene Summary for MAGI3-MAGI3

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGI3-MAGI3
Fusion gene ID: 50817
HgeneTgene
Gene symbol

MAGI3

MAGI3

Gene ID

260425

260425

Gene namemembrane associated guanylate kinase, WW and PDZ domain containing 3membrane associated guanylate kinase, WW and PDZ domain containing 3
SynonymsMAGI-3|dJ730K3.2MAGI-3|dJ730K3.2
Cytomap

1p13.2

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3
Modification date2020031320200313
UniProtAcc

Q5TCQ9

Q5TCQ9

Ensembl transtripts involved in fusion geneENST00000307546, ENST00000369611, 
ENST00000369615, ENST00000369617, 
ENST00000486456, 		ENST00000307546, 
ENST00000369611, ENST00000369615, 
ENST00000369617, ENST00000486456, 
Fusion gene scores* DoF score12 X 8 X 5=4805 X 5 X 2=50
# samples 125
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: MAGI3 [Title/Abstract] AND MAGI3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAGI3(114088935)-MAGI3(114085640), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAGI3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAGI3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAK021970MAGI3chr1

114088935

+MAGI3chr1

114085640

+


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Fusion Gene ORF analysis for MAGI3-MAGI3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000307546ENST00000307546MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000307546ENST00000369611MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000307546ENST00000369615MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000307546ENST00000369617MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000307546ENST00000486456MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369611ENST00000307546MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369611ENST00000369611MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369611ENST00000369615MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369611ENST00000369617MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369611ENST00000486456MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369615ENST00000307546MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369615ENST00000369611MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369615ENST00000369615MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369615ENST00000369617MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369615ENST00000486456MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369617ENST00000307546MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369617ENST00000369611MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369617ENST00000369615MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369617ENST00000369617MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000369617ENST00000486456MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000486456ENST00000307546MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000486456ENST00000369611MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000486456ENST00000369615MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000486456ENST00000369617MAGI3chr1

114088935

+MAGI3chr1

114085640

+
intron-intronENST00000486456ENST00000486456MAGI3chr1

114088935

+MAGI3chr1

114085640

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAGI3-MAGI3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAGI3-MAGI3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:114088935/:114085640)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI3

Q5TCQ9

MAGI3

Q5TCQ9

FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269|PubMed:10748157}.FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269|PubMed:10748157}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAGI3-MAGI3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAGI3-MAGI3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAGI3-MAGI3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAGI3-MAGI3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource