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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAGI3-NOTCH2NL (FusionGDB2 ID:50821)

Fusion Gene Summary for MAGI3-NOTCH2NL

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGI3-NOTCH2NL
Fusion gene ID: 50821
HgeneTgene
Gene symbol

MAGI3

NOTCH2NL

Gene ID

260425

100996763

Gene namemembrane associated guanylate kinase, WW and PDZ domain containing 3notch 2 N-terminal like B
SynonymsMAGI-3|dJ730K3.2N2N|NOTCH2NL|NOTCH2NLA
Cytomap

1p13.2

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionmembrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3notch homolog 2 N-terminal-like protein BNotch homolog 2 N-terminal-like protein Anotch homolog 2 N-terminal-like protein
Modification date2020031320200313
UniProtAcc

Q5TCQ9

P0DPK3

Ensembl transtripts involved in fusion geneENST00000486456, ENST00000307546, 
ENST00000369611, ENST00000369615, 
ENST00000369617, 		ENST00000344859, 
ENST00000362074, ENST00000369340, 
ENST00000479995, 
Fusion gene scores* DoF score12 X 8 X 5=4808 X 5 X 7=280
# samples 129
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAGI3 [Title/Abstract] AND NOTCH2NL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAGI3(113933971)-NOTCH2NL(145281368), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNOTCH2NL

GO:0021987

cerebral cortex development

29561261|29856954|29856955

TgeneNOTCH2NL

GO:0045747

positive regulation of Notch signaling pathway

29856954|29856955


check buttonFusion gene breakpoints across MAGI3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOTCH2NL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0W3MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+


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Fusion Gene ORF analysis for MAGI3-NOTCH2NL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486456ENST00000344859MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
3UTR-3CDSENST00000486456ENST00000362074MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
3UTR-3CDSENST00000486456ENST00000369340MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
3UTR-intronENST00000486456ENST00000479995MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
5CDS-intronENST00000307546ENST00000479995MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
5CDS-intronENST00000369611ENST00000479995MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
5CDS-intronENST00000369615ENST00000479995MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
5CDS-intronENST00000369617ENST00000479995MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000307546ENST00000344859MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000307546ENST00000362074MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000307546ENST00000369340MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369611ENST00000344859MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369611ENST00000362074MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369611ENST00000369340MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369615ENST00000344859MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369615ENST00000362074MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369615ENST00000369340MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369617ENST00000344859MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369617ENST00000362074MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+
In-frameENST00000369617ENST00000369340MAGI3chr1

113933971

+NOTCH2NLchr1

145281368

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369617MAGI3chr1113933971+ENST00000362074NOTCH2NLchr1145281368+18156012851013242
ENST00000369617MAGI3chr1113933971+ENST00000344859NOTCH2NLchr1145281368+1894601899180239
ENST00000369617MAGI3chr1113933971+ENST00000369340NOTCH2NLchr1145281368+48956012851013242
ENST00000307546MAGI3chr1113933971+ENST00000362074NOTCH2NLchr1145281368+160539175803242
ENST00000307546MAGI3chr1113933971+ENST00000344859NOTCH2NLchr1145281368+168439175785236
ENST00000307546MAGI3chr1113933971+ENST00000369340NOTCH2NLchr1145281368+468539175803242
ENST00000369615MAGI3chr1113933971+ENST00000362074NOTCH2NLchr1145281368+159237862790242
ENST00000369615MAGI3chr1113933971+ENST00000344859NOTCH2NLchr1145281368+167137862772236
ENST00000369615MAGI3chr1113933971+ENST00000369340NOTCH2NLchr1145281368+467237862790242
ENST00000369611MAGI3chr1113933971+ENST00000362074NOTCH2NLchr1145281368+157536145773242
ENST00000369611MAGI3chr1113933971+ENST00000344859NOTCH2NLchr1145281368+165436145755236
ENST00000369611MAGI3chr1113933971+ENST00000369340NOTCH2NLchr1145281368+465536145773242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369617ENST00000362074MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0272184550.9727816
ENST00000369617ENST00000344859MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0463822150.9536178
ENST00000369617ENST00000369340MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0047326030.9952674
ENST00000307546ENST00000362074MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0154500640.98455
ENST00000307546ENST00000344859MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0258789380.97412103
ENST00000307546ENST00000369340MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0042692690.9957307
ENST00000369615ENST00000362074MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0148431160.9851569
ENST00000369615ENST00000344859MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0238885170.9761114
ENST00000369615ENST00000369340MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0041934060.9958066
ENST00000369611ENST00000362074MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0135784130.9864216
ENST00000369611ENST00000344859MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0251111560.9748889
ENST00000369611ENST00000369340MAGI3chr1113933971+NOTCH2NLchr1145281368+0.0042341920.9957658

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Fusion Genomic Features for MAGI3-NOTCH2NL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAGI3-NOTCH2NL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:113933971/chr1:145281368)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI3

Q5TCQ9

NOTCH2NL

P0DPK3

FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269|PubMed:10748157}.FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955). {ECO:0000269|PubMed:29561261, ECO:0000269|PubMed:29856954, ECO:0000269|PubMed:29856955}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+1216_91051482.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+1216_91051126.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+1226_91052009.0Compositional biasNote=Poly-Lys
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+1226_91051151.0Compositional biasNote=Poly-Lys
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000034485926105_14199416.3333333333333DomainEGF-like 4
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000034485926143_18099416.3333333333333DomainEGF-like 5%3B calcium-binding
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000034485926182_21999416.3333333333333DomainEGF-like 6
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000036207425105_14199237.0DomainEGF-like 4
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000036207425143_18099237.0DomainEGF-like 5%3B calcium-binding
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000036207425182_21999237.0DomainEGF-like 6
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000036934036105_14199237.0DomainEGF-like 4
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000036934036143_18099237.0DomainEGF-like 5%3B calcium-binding
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST0000036934036182_21999237.0DomainEGF-like 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121238_2431051482.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121238_2431051126.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122238_2431052009.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122238_2431051151.0Compositional biasNote=Poly-Glu
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+1211021_11031051482.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121114_2881051482.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121293_3261051482.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121339_3721051482.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121578_6541051482.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+1211021_11031051126.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121114_2881051126.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121293_3261051126.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121339_3721051126.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121578_6541051126.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+1221021_11031052009.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122114_2881052009.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122293_3261052009.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122339_3721052009.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122578_6541052009.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+1221021_11031051151.0DomainPDZ 6
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122114_2881051151.0DomainGuanylate kinase-like
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122293_3261051151.0DomainWW 1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122339_3721051151.0DomainWW 2
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122578_6541051151.0DomainPDZ 3
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121121_1281051482.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121121_1281051126.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122121_1281052009.0Nucleotide bindingATP
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122121_1281051151.0Nucleotide bindingATP
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST00000344859261_2499416.3333333333333DomainEGF-like 1
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST000003448592625_6399416.3333333333333DomainEGF-like 2
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST000003448592666_10499416.3333333333333DomainEGF-like 3
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST00000362074251_2499237.0DomainEGF-like 1
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST000003620742525_6399237.0DomainEGF-like 2
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST000003620742566_10499237.0DomainEGF-like 3
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST00000369340361_2499237.0DomainEGF-like 1
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST000003693403625_6399237.0DomainEGF-like 2
TgeneNOTCH2NLchr1:113933971chr1:145281368ENST000003693403666_10499237.0DomainEGF-like 3


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Fusion Gene Sequence for MAGI3-NOTCH2NL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50821_50821_1_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000307546_NOTCH2NL_chr1_145281368_ENST00000344859_length(transcript)=1684nt_BP=391nt
CCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTG
AAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGT
GGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCC
AGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGC
GAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACC
TGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATT
CCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGT
GACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGC
CTTCCAGCAACATGGCCAATCTTTCCTAAGCTGCTCAGCTTACAAGAAAAGGAATCATACTGCTAAGAATTCAAACTTCAGCAGTCATAG
GGAGCCTTGGGAGGACCCCGAATCACTGATGGAATTGCGCAGTGCATGGAGATGGCTCAGCAGGATGAGGGTAAATGCAGGGGCAAGTCC
AGGCCATACTGAGAGACAATGAGTGGCGCTGATGAGGACAAAGATAAAATCAAAAGTTTGTGCTTCATCTTCAAAAACTCAAGCTGATAA
CAAACTTGGCCTGATGAGAAATAATAAGTATTTTTCTATTTACATGAGAATTTAATCTCAAAACAGAAATCAGAAAAATATGAAGTCCAG
GGCATAAAACCTAAAACTATTGCTCATATTTATTCTTTCTAAATAGAGCAAAGTGTAAAATCTTCTCCATAAGACATACATTGTGGTTAT
AAAAAGGCAAAAGTCTTAGTGAGAATCATTGGTATTCCATAGAAGAGTGAATTAAACACAGCCAAGGGAAGACCCACGTCTCATACTTCT
CTTGTATATTCCAAAGTTCCAGGGAAATTCCAGGTGATAGAGGTTATTTCCCATACTGTTAAAGCAAGGTTTCAGACACTTCTGAATTTT
GGTCCCAGTACTCTAGAAGGGCACACCTCTGTCCTGGAAAATAATACAGGAATGAATACTCTTCCCGTGACCCATTCTGGTCATTCTTCC
AGCATCACAAAAACCAAAAAATGGAAATATGGCCAAATACGTGATTAGCTGTCCCTCATCTTCAGGTTTCTTATCTGTTACTTATAGATA
ATAGCATTACCTTAAGGATTATGATGAAGATACAATGTCCAAATATAAACACAGTTTTGAGCAAAATGCCTTGTACGAATTGGTCAATGA

>50821_50821_1_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000307546_NOTCH2NL_chr1_145281368_ENST00000344859_length(amino acids)=236AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_2_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000307546_NOTCH2NL_chr1_145281368_ENST00000362074_length(transcript)=1605nt_BP=391nt
CCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTG
AAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGT
GGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCC
AGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGC
GAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACC
TGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATT
CCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGT
GACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGC
CTTCCAGAAACAGTGAGAAGAGGAACAGAGCTCTGGGAAAGAGACAGGGAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTG
GAAAATATGTATGTGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTGGGTGATCAACTTTACTATGTGCTTGTGCTTTTGC
TTTTGATGGAGTAATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTC
TCCCATGTACCCTCTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCA
GTGAGCACTTTTTGATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTC
TAGAGTGTACACACAACCCAAAGATAGAAATAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGG
AACAAGCTTGACCAATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGC
TGAATCAGATGAATTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGA
GTAATGTGCTAAGTAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGAT

>50821_50821_2_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000307546_NOTCH2NL_chr1_145281368_ENST00000362074_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_3_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000307546_NOTCH2NL_chr1_145281368_ENST00000369340_length(transcript)=4685nt_BP=391nt
CCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTG
AAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGT
GGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCC
AGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGC
GAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACC
TGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATT
CCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGT
GACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGC
CTTCCAGAAACAGTGAGAAGAGGAACAGAGCTCTGGGAAAGAGACAGGGAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTG
GAAAATATGTATGTGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTGGGTGATCAACTTTACTATGTGCTTGTGCTTTTGC
TTTTGATGGAGTAATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTC
TCCCATGTACCCTCTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCA
GTGAGCACTTTTTGATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTC
TAGAGTGTACACACAACCCAAAGATAGAAATAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGG
AACAAGCTTGACCAATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGC
TGAATCAGATGAATTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGA
GTAATGTGCTAAGTAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGAT
ATGGTTCACATATAATGGGATTGTGTGTTTTATTTTGGAGGGATTAAAGGTCATAGTTTGGTCCTCAGTATAAAATCAACTGGTAATTTA
TTCATTTCATTTGGTAAAAATGTATTGACTGCCTGCTATGTTCTAGGCACCATGCTATGTATTTGGAATACAGCTATACAAAGCATTGTC
ACATAATTGAAATGAAAATTTTATATTATTTAAGTCACAAGAACAAGCTATTTAATTATATTACTTTTAGTTTCTCTTTTAATAAAGAAT
AGATAATGCTATCATTCTAGATACTAAATAAGTATTTTCTTAACATAATATTACTATCCACTTTATCTTGTAGAAGAAATAACTAAAATA
CATCTGTCTTCACTCCTGTATTTGTTTGCATTTTAAGGATTAAAGACAGAAATAGAAATGTAAACAACTTTATTTTGAAAATATTTCAAC
ACTGCAAATATCTCTGGGTCTGATATTCTAGTAATCTAATTGGCTAGTAATTGATGTTAGTGTGATTTATTGTTGAAGGCTAAATGTGTT
TTTCAGTTTCAAGAAAATTGCTTTTAATAATTGCCTAGAACAAGAGGTTGATTTGGCAGCAAGATGTTGACGGGAAGTTAGAGAAGTCAA
TAAAGGAAGTTTTTAGCTGAGAGAGAGTGATTATTCACTCCCATAGCCTCTGCATTGTTATCCATTAGCCACGATAAGAACCTTAGGGAA
TTCTGAGAGTGTGTCCAGGAAAGGATCTGTCAAACTAGAATAGTATCTCCTCCTTGAGAAAGGAAATAACCAAGGATTCCGCAGCTGAGA
GGCTGCCAGGGCTAGTGAAATAGAGTAAGGAAATCTTGGCTGTCTCTTATTCTCTGGTTGTAGTTTAACGCAAGACACTTATTTACTCAC
TGATGGTGTGTGTGTGTGTGGGAGGGGAGATTAGCATGAGGGGTGGGAATGGGGAGATTCGATGAAGAGAAAACTAACATTTTTTTGGTG
ACTCAGGAACTGTGCCAGGTACTTCCATGCTTATTAGCTCAATTACACAAAAATCTTGGGACCAGGTATTATTTTTCAAGTCTTCCCACA
TGAAGTAACTGAAGTTTGGAGATGTTAAGTGATTCACCCAAAGTTGTACAGCTAATATGTGGTTAGGCTGGGTCCTGAAACCGAGGCAGT
TTATTTTCAAAGCCTTTGCTTTGTGCATCTTACTGCGCCACATTGCACTGCACATCTGCTTCCTGAAAGCACTTTGTAGGTGTGTAAAAC
TTTTCGTTAAATGCTTTAAGCTGTTTGGGTTAAAAATATATGTTCATGTTATAAGAAAACCAAGACACTCCTAATTATAATCAAATAGTA
CTTGTTACATATCAATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGGCGTTGTGCAGATGTTTAAAAGT
AGTTACATAGACTAGTTCTTGCTTTTCAGGGTCCCATAATCTAAACCAGATGACTTCAGCTTTGGATAAATATATAGAAGGAAATTTAAA
GAGAATTCAAAACAATAGATGATGCAGTGACACTGTGAATAAATGTTATTTATACAGTTTGTAAGATTTCATGCTCATTGTTCATATGTC
CCAGGTGGAGTTCAGAAAATATTCTCTTCATTTCCACAAAGGGGAATAGTGCCTGGAGATGGTTTTCTTTTAAAAAGTCCTTTTCATAAT
GCAGTGCCCTTCCTTCCATTGCCCTTCATTCCATTGCTTCCCATGCTTGTCAAGAGACTAAAATGTTACTTATAGTAATAGTCACTATCT
CAATGTAAATAGCACCCTTATTTGATGAGAATTATTATTTCAGTTCTAAAAATGGGGAAACAAAGTCAGCAGGAGGCAAAGTAGCTTGTT
AAAGTATTCTGCAACTTTCAAATGGTTGCTTCCACTGCATTTCACGTCTTGGCACTTCTAATTGAGGGTTACTCTAACCACCCTATTTAA
AATTGTAACTGTCCCCCACCCCCTTAATTACTAACCCTGGTCTACTTTTTGTTTTCTTTTTCTGTAACTCTTATCTTCTTACTATATAAT
TTATACTATATAATTTACTTCATTATGTCTATTGTTCATTGTCTGTCTTTTCCAAATTCTACTGCCTCTTACCCTCTCCAGAATGAAAAC
TAGTATCTTTGTTTTTGTTTACTGATGTAACCCAAACACCTACAAACAGTGCCCAGTATATACTAGGCCCACAAATATATATTGGCTGAC
TGACTGTATGGTTTAGTATCATGTCATAGTATTGAGACTGTAACTTTGGTCTTCTCATTTTCTTCTTTGTATTGTGCGTCCTAGACTTAG
TTTGGCCTCTCCTTTTGTCCTTGTATACTCTAATACTGGATAAGAATTTTGGAGTCTTTTTCAACTCTGAGTCAGTGAATGCCACATAAC
TTAGTGACTATATTTAAATGGTTAATTTACAATTTTTTCCCTGCAAAGGATACTGTAGTCACTGTGAGTATTTTAGTATTATTGTAGGAC
TCAAGAGGGAATTAAAACTACAAAAATGACTCCTCTTGTATGACACAGAAAGAAATGTTTCTTCACAGAGGGAGGAGAAAAATATCTTCA
AGAGAGAACTAATAGAATCAAATCAATGAACCATGTCTCATCTTTTTGGATAAGTAACTGTTAGTAATCCAGACACTTCATGAGCTTTCA
TTATGTAAAGTCTTTAGCAGAAGCTAAAGGAGGGGCACCAACCACAGTAATTTTAACTTAAGAACAAAATGGAGCATGAAAATAAATTAT
TAAATCATTTACTCCCACTATTTTTGGGTTAGGGCCAATAATGGGGAGAGAAAGAGGTAGACTAGTTTTGTGTTTGTGGCTATTTTAATA
GAGTAGCACAAGTAATCAAAAAACAGTAGGCTGTTTTGAATTTACTGGCTGTCCCTTATGAGTTCACAGTTAGATTGGACTGTCCTCAAT
GTACTTTCTTTTTTTTCTTTCTTTCCCACATCTCTTTATTTCTCTGATTTTGTTTAAACTTCATAAAGAGCTCTCTGATCTTTCCTTTCC
AAACAATGAAGGTTTATCCTTTGTAAACTACCTCTGTACTCCACAGGCTGATGATATGTGATATCCCTATATCATTAAAGTAAAGCCTAA

>50821_50821_3_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000307546_NOTCH2NL_chr1_145281368_ENST00000369340_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_4_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369611_NOTCH2NL_chr1_145281368_ENST00000344859_length(transcript)=1654nt_BP=361nt
CGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTG
CAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTG
GGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAAC
GGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCA
GGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGC
AAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGC
CTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCG
CCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGCAACATGGCCAATCTTTCCTAAG
CTGCTCAGCTTACAAGAAAAGGAATCATACTGCTAAGAATTCAAACTTCAGCAGTCATAGGGAGCCTTGGGAGGACCCCGAATCACTGAT
GGAATTGCGCAGTGCATGGAGATGGCTCAGCAGGATGAGGGTAAATGCAGGGGCAAGTCCAGGCCATACTGAGAGACAATGAGTGGCGCT
GATGAGGACAAAGATAAAATCAAAAGTTTGTGCTTCATCTTCAAAAACTCAAGCTGATAACAAACTTGGCCTGATGAGAAATAATAAGTA
TTTTTCTATTTACATGAGAATTTAATCTCAAAACAGAAATCAGAAAAATATGAAGTCCAGGGCATAAAACCTAAAACTATTGCTCATATT
TATTCTTTCTAAATAGAGCAAAGTGTAAAATCTTCTCCATAAGACATACATTGTGGTTATAAAAAGGCAAAAGTCTTAGTGAGAATCATT
GGTATTCCATAGAAGAGTGAATTAAACACAGCCAAGGGAAGACCCACGTCTCATACTTCTCTTGTATATTCCAAAGTTCCAGGGAAATTC
CAGGTGATAGAGGTTATTTCCCATACTGTTAAAGCAAGGTTTCAGACACTTCTGAATTTTGGTCCCAGTACTCTAGAAGGGCACACCTCT
GTCCTGGAAAATAATACAGGAATGAATACTCTTCCCGTGACCCATTCTGGTCATTCTTCCAGCATCACAAAAACCAAAAAATGGAAATAT
GGCCAAATACGTGATTAGCTGTCCCTCATCTTCAGGTTTCTTATCTGTTACTTATAGATAATAGCATTACCTTAAGGATTATGATGAAGA
TACAATGTCCAAATATAAACACAGTTTTGAGCAAAATGCCTTGTACGAATTGGTCAATGAATAATTACTAAATATGTGAATATTTCTGGA

>50821_50821_4_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369611_NOTCH2NL_chr1_145281368_ENST00000344859_length(amino acids)=236AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_5_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369611_NOTCH2NL_chr1_145281368_ENST00000362074_length(transcript)=1575nt_BP=361nt
CGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTG
CAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTG
GGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAAC
GGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCA
GGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGC
AAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGC
CTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCG
CCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAGAGGAACAGAG
CTCTGGGAAAGAGACAGGGAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATGTGTGGTTAATAAAGTGC
TTTAAACTGAATTGACATTAACAGTGGGTGATCAACTTTACTATGTGCTTGTGCTTTTGCTTTTGATGGAGTAATTCATTGTTTTCTTAT
CCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCTCTCTGACTTTGGGGTAA
CCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTTGATGAGCTGATAGATGA
TATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGTACACACAACCCAAAGATAGAAA
TAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCTTGACCAATTCATTCAACTCCTT
ATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGCTGAATCAGATGAATTACTAAGCAACAAAGA
TCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAGTAAGCAGAATTGCCTCA
AAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATATAATGGGATTGTGTGTTT

>50821_50821_5_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369611_NOTCH2NL_chr1_145281368_ENST00000362074_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_6_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369611_NOTCH2NL_chr1_145281368_ENST00000369340_length(transcript)=4655nt_BP=361nt
CGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTG
CAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTG
GGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAAC
GGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCA
GGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGC
AAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGC
CTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCG
CCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAGAGGAACAGAG
CTCTGGGAAAGAGACAGGGAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATGTGTGGTTAATAAAGTGC
TTTAAACTGAATTGACATTAACAGTGGGTGATCAACTTTACTATGTGCTTGTGCTTTTGCTTTTGATGGAGTAATTCATTGTTTTCTTAT
CCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCTCTCTGACTTTGGGGTAA
CCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTTGATGAGCTGATAGATGA
TATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGTACACACAACCCAAAGATAGAAA
TAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCTTGACCAATTCATTCAACTCCTT
ATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGCTGAATCAGATGAATTACTAAGCAACAAAGA
TCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAGTAAGCAGAATTGCCTCA
AAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATATAATGGGATTGTGTGTTT
TATTTTGGAGGGATTAAAGGTCATAGTTTGGTCCTCAGTATAAAATCAACTGGTAATTTATTCATTTCATTTGGTAAAAATGTATTGACT
GCCTGCTATGTTCTAGGCACCATGCTATGTATTTGGAATACAGCTATACAAAGCATTGTCACATAATTGAAATGAAAATTTTATATTATT
TAAGTCACAAGAACAAGCTATTTAATTATATTACTTTTAGTTTCTCTTTTAATAAAGAATAGATAATGCTATCATTCTAGATACTAAATA
AGTATTTTCTTAACATAATATTACTATCCACTTTATCTTGTAGAAGAAATAACTAAAATACATCTGTCTTCACTCCTGTATTTGTTTGCA
TTTTAAGGATTAAAGACAGAAATAGAAATGTAAACAACTTTATTTTGAAAATATTTCAACACTGCAAATATCTCTGGGTCTGATATTCTA
GTAATCTAATTGGCTAGTAATTGATGTTAGTGTGATTTATTGTTGAAGGCTAAATGTGTTTTTCAGTTTCAAGAAAATTGCTTTTAATAA
TTGCCTAGAACAAGAGGTTGATTTGGCAGCAAGATGTTGACGGGAAGTTAGAGAAGTCAATAAAGGAAGTTTTTAGCTGAGAGAGAGTGA
TTATTCACTCCCATAGCCTCTGCATTGTTATCCATTAGCCACGATAAGAACCTTAGGGAATTCTGAGAGTGTGTCCAGGAAAGGATCTGT
CAAACTAGAATAGTATCTCCTCCTTGAGAAAGGAAATAACCAAGGATTCCGCAGCTGAGAGGCTGCCAGGGCTAGTGAAATAGAGTAAGG
AAATCTTGGCTGTCTCTTATTCTCTGGTTGTAGTTTAACGCAAGACACTTATTTACTCACTGATGGTGTGTGTGTGTGTGGGAGGGGAGA
TTAGCATGAGGGGTGGGAATGGGGAGATTCGATGAAGAGAAAACTAACATTTTTTTGGTGACTCAGGAACTGTGCCAGGTACTTCCATGC
TTATTAGCTCAATTACACAAAAATCTTGGGACCAGGTATTATTTTTCAAGTCTTCCCACATGAAGTAACTGAAGTTTGGAGATGTTAAGT
GATTCACCCAAAGTTGTACAGCTAATATGTGGTTAGGCTGGGTCCTGAAACCGAGGCAGTTTATTTTCAAAGCCTTTGCTTTGTGCATCT
TACTGCGCCACATTGCACTGCACATCTGCTTCCTGAAAGCACTTTGTAGGTGTGTAAAACTTTTCGTTAAATGCTTTAAGCTGTTTGGGT
TAAAAATATATGTTCATGTTATAAGAAAACCAAGACACTCCTAATTATAATCAAATAGTACTTGTTACATATCAATATGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGGCGTTGTGCAGATGTTTAAAAGTAGTTACATAGACTAGTTCTTGCTTTTCAGG
GTCCCATAATCTAAACCAGATGACTTCAGCTTTGGATAAATATATAGAAGGAAATTTAAAGAGAATTCAAAACAATAGATGATGCAGTGA
CACTGTGAATAAATGTTATTTATACAGTTTGTAAGATTTCATGCTCATTGTTCATATGTCCCAGGTGGAGTTCAGAAAATATTCTCTTCA
TTTCCACAAAGGGGAATAGTGCCTGGAGATGGTTTTCTTTTAAAAAGTCCTTTTCATAATGCAGTGCCCTTCCTTCCATTGCCCTTCATT
CCATTGCTTCCCATGCTTGTCAAGAGACTAAAATGTTACTTATAGTAATAGTCACTATCTCAATGTAAATAGCACCCTTATTTGATGAGA
ATTATTATTTCAGTTCTAAAAATGGGGAAACAAAGTCAGCAGGAGGCAAAGTAGCTTGTTAAAGTATTCTGCAACTTTCAAATGGTTGCT
TCCACTGCATTTCACGTCTTGGCACTTCTAATTGAGGGTTACTCTAACCACCCTATTTAAAATTGTAACTGTCCCCCACCCCCTTAATTA
CTAACCCTGGTCTACTTTTTGTTTTCTTTTTCTGTAACTCTTATCTTCTTACTATATAATTTATACTATATAATTTACTTCATTATGTCT
ATTGTTCATTGTCTGTCTTTTCCAAATTCTACTGCCTCTTACCCTCTCCAGAATGAAAACTAGTATCTTTGTTTTTGTTTACTGATGTAA
CCCAAACACCTACAAACAGTGCCCAGTATATACTAGGCCCACAAATATATATTGGCTGACTGACTGTATGGTTTAGTATCATGTCATAGT
ATTGAGACTGTAACTTTGGTCTTCTCATTTTCTTCTTTGTATTGTGCGTCCTAGACTTAGTTTGGCCTCTCCTTTTGTCCTTGTATACTC
TAATACTGGATAAGAATTTTGGAGTCTTTTTCAACTCTGAGTCAGTGAATGCCACATAACTTAGTGACTATATTTAAATGGTTAATTTAC
AATTTTTTCCCTGCAAAGGATACTGTAGTCACTGTGAGTATTTTAGTATTATTGTAGGACTCAAGAGGGAATTAAAACTACAAAAATGAC
TCCTCTTGTATGACACAGAAAGAAATGTTTCTTCACAGAGGGAGGAGAAAAATATCTTCAAGAGAGAACTAATAGAATCAAATCAATGAA
CCATGTCTCATCTTTTTGGATAAGTAACTGTTAGTAATCCAGACACTTCATGAGCTTTCATTATGTAAAGTCTTTAGCAGAAGCTAAAGG
AGGGGCACCAACCACAGTAATTTTAACTTAAGAACAAAATGGAGCATGAAAATAAATTATTAAATCATTTACTCCCACTATTTTTGGGTT
AGGGCCAATAATGGGGAGAGAAAGAGGTAGACTAGTTTTGTGTTTGTGGCTATTTTAATAGAGTAGCACAAGTAATCAAAAAACAGTAGG
CTGTTTTGAATTTACTGGCTGTCCCTTATGAGTTCACAGTTAGATTGGACTGTCCTCAATGTACTTTCTTTTTTTTCTTTCTTTCCCACA
TCTCTTTATTTCTCTGATTTTGTTTAAACTTCATAAAGAGCTCTCTGATCTTTCCTTTCCAAACAATGAAGGTTTATCCTTTGTAAACTA

>50821_50821_6_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369611_NOTCH2NL_chr1_145281368_ENST00000369340_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_7_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369615_NOTCH2NL_chr1_145281368_ENST00000344859_length(transcript)=1671nt_BP=378nt
GGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGC
ACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTG
GCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATG
TGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTC
TCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGG
CCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCC
AGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATG
TGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGCAACAT
GGCCAATCTTTCCTAAGCTGCTCAGCTTACAAGAAAAGGAATCATACTGCTAAGAATTCAAACTTCAGCAGTCATAGGGAGCCTTGGGAG
GACCCCGAATCACTGATGGAATTGCGCAGTGCATGGAGATGGCTCAGCAGGATGAGGGTAAATGCAGGGGCAAGTCCAGGCCATACTGAG
AGACAATGAGTGGCGCTGATGAGGACAAAGATAAAATCAAAAGTTTGTGCTTCATCTTCAAAAACTCAAGCTGATAACAAACTTGGCCTG
ATGAGAAATAATAAGTATTTTTCTATTTACATGAGAATTTAATCTCAAAACAGAAATCAGAAAAATATGAAGTCCAGGGCATAAAACCTA
AAACTATTGCTCATATTTATTCTTTCTAAATAGAGCAAAGTGTAAAATCTTCTCCATAAGACATACATTGTGGTTATAAAAAGGCAAAAG
TCTTAGTGAGAATCATTGGTATTCCATAGAAGAGTGAATTAAACACAGCCAAGGGAAGACCCACGTCTCATACTTCTCTTGTATATTCCA
AAGTTCCAGGGAAATTCCAGGTGATAGAGGTTATTTCCCATACTGTTAAAGCAAGGTTTCAGACACTTCTGAATTTTGGTCCCAGTACTC
TAGAAGGGCACACCTCTGTCCTGGAAAATAATACAGGAATGAATACTCTTCCCGTGACCCATTCTGGTCATTCTTCCAGCATCACAAAAA
CCAAAAAATGGAAATATGGCCAAATACGTGATTAGCTGTCCCTCATCTTCAGGTTTCTTATCTGTTACTTATAGATAATAGCATTACCTT
AAGGATTATGATGAAGATACAATGTCCAAATATAAACACAGTTTTGAGCAAAATGCCTTGTACGAATTGGTCAATGAATAATTACTAAAT

>50821_50821_7_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369615_NOTCH2NL_chr1_145281368_ENST00000344859_length(amino acids)=236AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_8_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369615_NOTCH2NL_chr1_145281368_ENST00000362074_length(transcript)=1592nt_BP=378nt
GGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGC
ACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTG
GCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATG
TGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTC
TCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGG
CCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCC
AGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATG
TGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAG
TGAGAAGAGGAACAGAGCTCTGGGAAAGAGACAGGGAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATG
TGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTGGGTGATCAACTTTACTATGTGCTTGTGCTTTTGCTTTTGATGGAGTA
ATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCT
CTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTT
GATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGTACACA
CAACCCAAAGATAGAAATAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCTTGACC
AATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGCTGAATCAGATGAA
TTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAG
TAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATAT

>50821_50821_8_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369615_NOTCH2NL_chr1_145281368_ENST00000362074_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_9_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369615_NOTCH2NL_chr1_145281368_ENST00000369340_length(transcript)=4672nt_BP=378nt
GGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGC
ACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTG
GCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATG
TGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTC
TCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGG
CCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAGTGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCC
AGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATG
TGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAG
TGAGAAGAGGAACAGAGCTCTGGGAAAGAGACAGGGAAGTCTGGAATGGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATG
TGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTGGGTGATCAACTTTACTATGTGCTTGTGCTTTTGCTTTTGATGGAGTA
ATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATTTTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCT
CTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCTGAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTT
GATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACTTTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGTACACA
CAACCCAAAGATAGAAATAAAAAGAGGAGCAGTGTCGGGGAGCTTGGGGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCTTGACC
AATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAGAATTTTGATTGGGAACAGAATACAAGCAGCTGAATCAGATGAA
TTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACAAAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAG
TAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGAGTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATAT
AATGGGATTGTGTGTTTTATTTTGGAGGGATTAAAGGTCATAGTTTGGTCCTCAGTATAAAATCAACTGGTAATTTATTCATTTCATTTG
GTAAAAATGTATTGACTGCCTGCTATGTTCTAGGCACCATGCTATGTATTTGGAATACAGCTATACAAAGCATTGTCACATAATTGAAAT
GAAAATTTTATATTATTTAAGTCACAAGAACAAGCTATTTAATTATATTACTTTTAGTTTCTCTTTTAATAAAGAATAGATAATGCTATC
ATTCTAGATACTAAATAAGTATTTTCTTAACATAATATTACTATCCACTTTATCTTGTAGAAGAAATAACTAAAATACATCTGTCTTCAC
TCCTGTATTTGTTTGCATTTTAAGGATTAAAGACAGAAATAGAAATGTAAACAACTTTATTTTGAAAATATTTCAACACTGCAAATATCT
CTGGGTCTGATATTCTAGTAATCTAATTGGCTAGTAATTGATGTTAGTGTGATTTATTGTTGAAGGCTAAATGTGTTTTTCAGTTTCAAG
AAAATTGCTTTTAATAATTGCCTAGAACAAGAGGTTGATTTGGCAGCAAGATGTTGACGGGAAGTTAGAGAAGTCAATAAAGGAAGTTTT
TAGCTGAGAGAGAGTGATTATTCACTCCCATAGCCTCTGCATTGTTATCCATTAGCCACGATAAGAACCTTAGGGAATTCTGAGAGTGTG
TCCAGGAAAGGATCTGTCAAACTAGAATAGTATCTCCTCCTTGAGAAAGGAAATAACCAAGGATTCCGCAGCTGAGAGGCTGCCAGGGCT
AGTGAAATAGAGTAAGGAAATCTTGGCTGTCTCTTATTCTCTGGTTGTAGTTTAACGCAAGACACTTATTTACTCACTGATGGTGTGTGT
GTGTGTGGGAGGGGAGATTAGCATGAGGGGTGGGAATGGGGAGATTCGATGAAGAGAAAACTAACATTTTTTTGGTGACTCAGGAACTGT
GCCAGGTACTTCCATGCTTATTAGCTCAATTACACAAAAATCTTGGGACCAGGTATTATTTTTCAAGTCTTCCCACATGAAGTAACTGAA
GTTTGGAGATGTTAAGTGATTCACCCAAAGTTGTACAGCTAATATGTGGTTAGGCTGGGTCCTGAAACCGAGGCAGTTTATTTTCAAAGC
CTTTGCTTTGTGCATCTTACTGCGCCACATTGCACTGCACATCTGCTTCCTGAAAGCACTTTGTAGGTGTGTAAAACTTTTCGTTAAATG
CTTTAAGCTGTTTGGGTTAAAAATATATGTTCATGTTATAAGAAAACCAAGACACTCCTAATTATAATCAAATAGTACTTGTTACATATC
AATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGGCGTTGTGCAGATGTTTAAAAGTAGTTACATAGACT
AGTTCTTGCTTTTCAGGGTCCCATAATCTAAACCAGATGACTTCAGCTTTGGATAAATATATAGAAGGAAATTTAAAGAGAATTCAAAAC
AATAGATGATGCAGTGACACTGTGAATAAATGTTATTTATACAGTTTGTAAGATTTCATGCTCATTGTTCATATGTCCCAGGTGGAGTTC
AGAAAATATTCTCTTCATTTCCACAAAGGGGAATAGTGCCTGGAGATGGTTTTCTTTTAAAAAGTCCTTTTCATAATGCAGTGCCCTTCC
TTCCATTGCCCTTCATTCCATTGCTTCCCATGCTTGTCAAGAGACTAAAATGTTACTTATAGTAATAGTCACTATCTCAATGTAAATAGC
ACCCTTATTTGATGAGAATTATTATTTCAGTTCTAAAAATGGGGAAACAAAGTCAGCAGGAGGCAAAGTAGCTTGTTAAAGTATTCTGCA
ACTTTCAAATGGTTGCTTCCACTGCATTTCACGTCTTGGCACTTCTAATTGAGGGTTACTCTAACCACCCTATTTAAAATTGTAACTGTC
CCCCACCCCCTTAATTACTAACCCTGGTCTACTTTTTGTTTTCTTTTTCTGTAACTCTTATCTTCTTACTATATAATTTATACTATATAA
TTTACTTCATTATGTCTATTGTTCATTGTCTGTCTTTTCCAAATTCTACTGCCTCTTACCCTCTCCAGAATGAAAACTAGTATCTTTGTT
TTTGTTTACTGATGTAACCCAAACACCTACAAACAGTGCCCAGTATATACTAGGCCCACAAATATATATTGGCTGACTGACTGTATGGTT
TAGTATCATGTCATAGTATTGAGACTGTAACTTTGGTCTTCTCATTTTCTTCTTTGTATTGTGCGTCCTAGACTTAGTTTGGCCTCTCCT
TTTGTCCTTGTATACTCTAATACTGGATAAGAATTTTGGAGTCTTTTTCAACTCTGAGTCAGTGAATGCCACATAACTTAGTGACTATAT
TTAAATGGTTAATTTACAATTTTTTCCCTGCAAAGGATACTGTAGTCACTGTGAGTATTTTAGTATTATTGTAGGACTCAAGAGGGAATT
AAAACTACAAAAATGACTCCTCTTGTATGACACAGAAAGAAATGTTTCTTCACAGAGGGAGGAGAAAAATATCTTCAAGAGAGAACTAAT
AGAATCAAATCAATGAACCATGTCTCATCTTTTTGGATAAGTAACTGTTAGTAATCCAGACACTTCATGAGCTTTCATTATGTAAAGTCT
TTAGCAGAAGCTAAAGGAGGGGCACCAACCACAGTAATTTTAACTTAAGAACAAAATGGAGCATGAAAATAAATTATTAAATCATTTACT
CCCACTATTTTTGGGTTAGGGCCAATAATGGGGAGAGAAAGAGGTAGACTAGTTTTGTGTTTGTGGCTATTTTAATAGAGTAGCACAAGT
AATCAAAAAACAGTAGGCTGTTTTGAATTTACTGGCTGTCCCTTATGAGTTCACAGTTAGATTGGACTGTCCTCAATGTACTTTCTTTTT
TTTCTTTCTTTCCCACATCTCTTTATTTCTCTGATTTTGTTTAAACTTCATAAAGAGCTCTCTGATCTTTCCTTTCCAAACAATGAAGGT

>50821_50821_9_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369615_NOTCH2NL_chr1_145281368_ENST00000369340_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_10_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369617_NOTCH2NL_chr1_145281368_ENST00000344859_length(transcript)=1894nt_BP=601nt
CTCCTGGGGACAATTCCCTTTTCCTTTCTTCAGCCTAACCCGCGGTGGCCCTCGCGGAGTCCGGTCAGCCCCGGGGAGCGCAGCCGGGAG
GGGCGTCCAAGGGGCGTCTCGCGTCTGGGAACGGCCGGGCCCCCAGCGGGCTGTGGTCGCGGGGTGGGGGCCGGAGCGGCGAGGCCCCCC
TTACCGGGCTGCGCGGGCCGCCCAGGGCCCCCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGT
GCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCC
CCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGC
ACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGG
GACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGC
CTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAG
TGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAG
TGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAG
ACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGCAACATGGCCAATCTTTCCTAAGCTGCTCAGCTTACAAGAAAAGGAATCATAC
TGCTAAGAATTCAAACTTCAGCAGTCATAGGGAGCCTTGGGAGGACCCCGAATCACTGATGGAATTGCGCAGTGCATGGAGATGGCTCAG
CAGGATGAGGGTAAATGCAGGGGCAAGTCCAGGCCATACTGAGAGACAATGAGTGGCGCTGATGAGGACAAAGATAAAATCAAAAGTTTG
TGCTTCATCTTCAAAAACTCAAGCTGATAACAAACTTGGCCTGATGAGAAATAATAAGTATTTTTCTATTTACATGAGAATTTAATCTCA
AAACAGAAATCAGAAAAATATGAAGTCCAGGGCATAAAACCTAAAACTATTGCTCATATTTATTCTTTCTAAATAGAGCAAAGTGTAAAA
TCTTCTCCATAAGACATACATTGTGGTTATAAAAAGGCAAAAGTCTTAGTGAGAATCATTGGTATTCCATAGAAGAGTGAATTAAACACA
GCCAAGGGAAGACCCACGTCTCATACTTCTCTTGTATATTCCAAAGTTCCAGGGAAATTCCAGGTGATAGAGGTTATTTCCCATACTGTT
AAAGCAAGGTTTCAGACACTTCTGAATTTTGGTCCCAGTACTCTAGAAGGGCACACCTCTGTCCTGGAAAATAATACAGGAATGAATACT
CTTCCCGTGACCCATTCTGGTCATTCTTCCAGCATCACAAAAACCAAAAAATGGAAATATGGCCAAATACGTGATTAGCTGTCCCTCATC
TTCAGGTTTCTTATCTGTTACTTATAGATAATAGCATTACCTTAAGGATTATGATGAAGATACAATGTCCAAATATAAACACAGTTTTGA
GCAAAATGCCTTGTACGAATTGGTCAATGAATAATTACTAAATATGTGAATATTTCTGGATTGTATGGATCCTATGAATAATTACTGAAT

>50821_50821_10_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369617_NOTCH2NL_chr1_145281368_ENST00000344859_length(amino acids)=239AA_BP=1
MPTGASIDTRRGCTGHIQAVTVLACEALKALALVGTRQVEAGATMLAVSWNVTLIDISLTLLPCEACEAFAGELVGHSGTGTSICTGMRQ
AGIGPLALLTWFHSLETDGLAEVADDSQGVPVGEPADRRPVYLQQHIAWAGRLARDDAAGAPAGLLAEPPQVGELATLRATADLRAEVAR

--------------------------------------------------------------
>50821_50821_11_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369617_NOTCH2NL_chr1_145281368_ENST00000362074_length(transcript)=1815nt_BP=601nt
CTCCTGGGGACAATTCCCTTTTCCTTTCTTCAGCCTAACCCGCGGTGGCCCTCGCGGAGTCCGGTCAGCCCCGGGGAGCGCAGCCGGGAG
GGGCGTCCAAGGGGCGTCTCGCGTCTGGGAACGGCCGGGCCCCCAGCGGGCTGTGGTCGCGGGGTGGGGGCCGGAGCGGCGAGGCCCCCC
TTACCGGGCTGCGCGGGCCGCCCAGGGCCCCCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGT
GCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCC
CCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGC
ACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGG
GACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGC
CTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAG
TGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAG
TGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAG
ACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAGAGGAACAGAGCTCTGGGAAAGAGACAGGGAAGTCTGGAAT
GGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATGTGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTGGGTG
ATCAACTTTACTATGTGCTTGTGCTTTTGCTTTTGATGGAGTAATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATT
TTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCTCTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCT
GAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTTGATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACT
TTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGTACACACAACCCAAAGATAGAAATAAAAAGAGGAGCAGTGTCGGGGAGCTTGG
GGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCTTGACCAATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAG
AATTTTGATTGGGAACAGAATACAAGCAGCTGAATCAGATGAATTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACA
AAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAGTAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGA
GTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATATAATGGGATTGTGTGTTTTATTTTGGAGGGATTAAAGGTCATAGTTTG

>50821_50821_11_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369617_NOTCH2NL_chr1_145281368_ENST00000362074_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

--------------------------------------------------------------
>50821_50821_12_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369617_NOTCH2NL_chr1_145281368_ENST00000369340_length(transcript)=4895nt_BP=601nt
CTCCTGGGGACAATTCCCTTTTCCTTTCTTCAGCCTAACCCGCGGTGGCCCTCGCGGAGTCCGGTCAGCCCCGGGGAGCGCAGCCGGGAG
GGGCGTCCAAGGGGCGTCTCGCGTCTGGGAACGGCCGGGCCCCCAGCGGGCTGTGGTCGCGGGGTGGGGGCCGGAGCGGCGAGGCCCCCC
TTACCGGGCTGCGCGGGCCGCCCAGGGCCCCCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGT
GCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCC
CCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGC
ACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGG
GACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGTAAGGAGTGCCAATGGACCGATGCCTGC
CTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAG
TGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAG
TGCCTTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCGCCTTGTGTCAATGGAGGCACCTGTCGGCAG
ACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGAAACAGTGAGAAGAGGAACAGAGCTCTGGGAAAGAGACAGGGAAGTCTGGAAT
GGAAAAGAACACGATGAGAATTAGACACTGGAAAATATGTATGTGTGGTTAATAAAGTGCTTTAAACTGAATTGACATTAACAGTGGGTG
ATCAACTTTACTATGTGCTTGTGCTTTTGCTTTTGATGGAGTAATTCATTGTTTTCTTATCCACCTAAATGCACCCAGCTGCCCTTGATT
TTCTCTGGGCTACTGGCCTTCACAACCCTCTCCCATGTACCCTCTCTGACTTTGGGGTAACCCTCCCCTAACTTAAAGCTAGAGAATTCT
GAAACTGAGGAGGGGATCCTCTGTTAATCAGTGAGCACTTTTTGATGAGCTGATAGATGATATATGAGAGACTATGCGTGGCACAATACT
TTGTTACACTCTTCACTGATACAAGTGTTCTAGAGTGTACACACAACCCAAAGATAGAAATAAAAAGAGGAGCAGTGTCGGGGAGCTTGG
GGCCTGGTGTTCCATGGAGAGGGAGAAAGGAACAAGCTTGACCAATTCATTCAACTCCTTATAAAAATGATGAGGAGGCTGAAAACCAAG
AATTTTGATTGGGAACAGAATACAAGCAGCTGAATCAGATGAATTACTAAGCAACAAAGATCCTGTTTTTATACAAATATCCTTAGTACA
AAAACAAAAGAAGGAAAACTGTAGGGGGGAGTAATGTGCTAAGTAAGCAGAATTGCCTCAAAAAGAAGTTGTTCTAGTTACTCTTTCAGA
GTGGGAATCTTAGATTCTGGTATTGTGGATATGGTTCACATATAATGGGATTGTGTGTTTTATTTTGGAGGGATTAAAGGTCATAGTTTG
GTCCTCAGTATAAAATCAACTGGTAATTTATTCATTTCATTTGGTAAAAATGTATTGACTGCCTGCTATGTTCTAGGCACCATGCTATGT
ATTTGGAATACAGCTATACAAAGCATTGTCACATAATTGAAATGAAAATTTTATATTATTTAAGTCACAAGAACAAGCTATTTAATTATA
TTACTTTTAGTTTCTCTTTTAATAAAGAATAGATAATGCTATCATTCTAGATACTAAATAAGTATTTTCTTAACATAATATTACTATCCA
CTTTATCTTGTAGAAGAAATAACTAAAATACATCTGTCTTCACTCCTGTATTTGTTTGCATTTTAAGGATTAAAGACAGAAATAGAAATG
TAAACAACTTTATTTTGAAAATATTTCAACACTGCAAATATCTCTGGGTCTGATATTCTAGTAATCTAATTGGCTAGTAATTGATGTTAG
TGTGATTTATTGTTGAAGGCTAAATGTGTTTTTCAGTTTCAAGAAAATTGCTTTTAATAATTGCCTAGAACAAGAGGTTGATTTGGCAGC
AAGATGTTGACGGGAAGTTAGAGAAGTCAATAAAGGAAGTTTTTAGCTGAGAGAGAGTGATTATTCACTCCCATAGCCTCTGCATTGTTA
TCCATTAGCCACGATAAGAACCTTAGGGAATTCTGAGAGTGTGTCCAGGAAAGGATCTGTCAAACTAGAATAGTATCTCCTCCTTGAGAA
AGGAAATAACCAAGGATTCCGCAGCTGAGAGGCTGCCAGGGCTAGTGAAATAGAGTAAGGAAATCTTGGCTGTCTCTTATTCTCTGGTTG
TAGTTTAACGCAAGACACTTATTTACTCACTGATGGTGTGTGTGTGTGTGGGAGGGGAGATTAGCATGAGGGGTGGGAATGGGGAGATTC
GATGAAGAGAAAACTAACATTTTTTTGGTGACTCAGGAACTGTGCCAGGTACTTCCATGCTTATTAGCTCAATTACACAAAAATCTTGGG
ACCAGGTATTATTTTTCAAGTCTTCCCACATGAAGTAACTGAAGTTTGGAGATGTTAAGTGATTCACCCAAAGTTGTACAGCTAATATGT
GGTTAGGCTGGGTCCTGAAACCGAGGCAGTTTATTTTCAAAGCCTTTGCTTTGTGCATCTTACTGCGCCACATTGCACTGCACATCTGCT
TCCTGAAAGCACTTTGTAGGTGTGTAAAACTTTTCGTTAAATGCTTTAAGCTGTTTGGGTTAAAAATATATGTTCATGTTATAAGAAAAC
CAAGACACTCCTAATTATAATCAAATAGTACTTGTTACATATCAATATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT
GTGTATGGCGTTGTGCAGATGTTTAAAAGTAGTTACATAGACTAGTTCTTGCTTTTCAGGGTCCCATAATCTAAACCAGATGACTTCAGC
TTTGGATAAATATATAGAAGGAAATTTAAAGAGAATTCAAAACAATAGATGATGCAGTGACACTGTGAATAAATGTTATTTATACAGTTT
GTAAGATTTCATGCTCATTGTTCATATGTCCCAGGTGGAGTTCAGAAAATATTCTCTTCATTTCCACAAAGGGGAATAGTGCCTGGAGAT
GGTTTTCTTTTAAAAAGTCCTTTTCATAATGCAGTGCCCTTCCTTCCATTGCCCTTCATTCCATTGCTTCCCATGCTTGTCAAGAGACTA
AAATGTTACTTATAGTAATAGTCACTATCTCAATGTAAATAGCACCCTTATTTGATGAGAATTATTATTTCAGTTCTAAAAATGGGGAAA
CAAAGTCAGCAGGAGGCAAAGTAGCTTGTTAAAGTATTCTGCAACTTTCAAATGGTTGCTTCCACTGCATTTCACGTCTTGGCACTTCTA
ATTGAGGGTTACTCTAACCACCCTATTTAAAATTGTAACTGTCCCCCACCCCCTTAATTACTAACCCTGGTCTACTTTTTGTTTTCTTTT
TCTGTAACTCTTATCTTCTTACTATATAATTTATACTATATAATTTACTTCATTATGTCTATTGTTCATTGTCTGTCTTTTCCAAATTCT
ACTGCCTCTTACCCTCTCCAGAATGAAAACTAGTATCTTTGTTTTTGTTTACTGATGTAACCCAAACACCTACAAACAGTGCCCAGTATA
TACTAGGCCCACAAATATATATTGGCTGACTGACTGTATGGTTTAGTATCATGTCATAGTATTGAGACTGTAACTTTGGTCTTCTCATTT
TCTTCTTTGTATTGTGCGTCCTAGACTTAGTTTGGCCTCTCCTTTTGTCCTTGTATACTCTAATACTGGATAAGAATTTTGGAGTCTTTT
TCAACTCTGAGTCAGTGAATGCCACATAACTTAGTGACTATATTTAAATGGTTAATTTACAATTTTTTCCCTGCAAAGGATACTGTAGTC
ACTGTGAGTATTTTAGTATTATTGTAGGACTCAAGAGGGAATTAAAACTACAAAAATGACTCCTCTTGTATGACACAGAAAGAAATGTTT
CTTCACAGAGGGAGGAGAAAAATATCTTCAAGAGAGAACTAATAGAATCAAATCAATGAACCATGTCTCATCTTTTTGGATAAGTAACTG
TTAGTAATCCAGACACTTCATGAGCTTTCATTATGTAAAGTCTTTAGCAGAAGCTAAAGGAGGGGCACCAACCACAGTAATTTTAACTTA
AGAACAAAATGGAGCATGAAAATAAATTATTAAATCATTTACTCCCACTATTTTTGGGTTAGGGCCAATAATGGGGAGAGAAAGAGGTAG
ACTAGTTTTGTGTTTGTGGCTATTTTAATAGAGTAGCACAAGTAATCAAAAAACAGTAGGCTGTTTTGAATTTACTGGCTGTCCCTTATG
AGTTCACAGTTAGATTGGACTGTCCTCAATGTACTTTCTTTTTTTTCTTTCTTTCCCACATCTCTTTATTTCTCTGATTTTGTTTAAACT
TCATAAAGAGCTCTCTGATCTTTCCTTTCCAAACAATGAAGGTTTATCCTTTGTAAACTACCTCTGTACTCCACAGGCTGATGATATGTG

>50821_50821_12_MAGI3-NOTCH2NL_MAGI3_chr1_113933971_ENST00000369617_NOTCH2NL_chr1_145281368_ENST00000369340_length(amino acids)=242AA_BP=105
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF

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Fusion Gene PPI Analysis for MAGI3-NOTCH2NL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+12118_106105.333333333333331482.0ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+12118_106105.333333333333331126.0ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+12218_106105.333333333333332009.0ADRB1 and TGFA
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+12218_106105.333333333333331151.0ADRB1 and TGFA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121726_808105.333333333333331482.0ADGRB1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121726_808105.333333333333331126.0ADGRB1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122726_808105.333333333333332009.0ADGRB1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122726_808105.333333333333331151.0ADGRB1
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121851_938105.333333333333331482.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121851_938105.333333333333331126.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122851_938105.333333333333332009.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122851_938105.333333333333331151.0LPAR2 and GRIN2B
HgeneMAGI3chr1:113933971chr1:145281368ENST00000307546+121410_492105.333333333333331482.0PTEN
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369611+121410_492105.333333333333331126.0PTEN
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369615+122410_492105.333333333333332009.0PTEN
HgeneMAGI3chr1:113933971chr1:145281368ENST00000369617+122410_492105.333333333333331151.0PTEN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAGI3-NOTCH2NL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAGI3-NOTCH2NL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource