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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAGI3-RGS18 (FusionGDB2 ID:50823)

Fusion Gene Summary for MAGI3-RGS18

Fusion gene summary

Fusion gene information	Fusion gene name: MAGI3-RGS18
	Fusion gene ID: 50823
		Hgene	Tgene
	Gene symbol	MAGI3	RGS18
	Gene ID	260425	64407
	Gene name	membrane associated guanylate kinase, WW and PDZ domain containing 3	regulator of G protein signaling 18
	Synonyms	MAGI-3\|dJ730K3.2	RGS13
	Cytomap	1p13.2	1q31.2
	Type of gene	protein-coding	protein-coding
	Description	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3	regulator of G-protein signaling 18regulator of G-protein signalling 13regulator of G-protein signalling 18
	Modification date	20200313	20200313
	UniProtAcc	Q5TCQ9	.
	Ensembl transtripts involved in fusion gene	ENST00000486456, ENST00000307546, ENST00000369611, ENST00000369615, ENST00000369617,	ENST00000367460, ENST00000481707,
Fusion gene scores	* DoF score	12 X 8 X 5=480	2 X 2 X 2=8
	# samples	12	2
	** MAII score	log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: MAGI3 [Title/Abstract] AND RGS18 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAGI3(114092253)-RGS18(192150421), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAGI3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RGS18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-JY-A6F8	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+

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Fusion Gene ORF analysis for MAGI3-RGS18

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000486456	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
3UTR-intron	ENST00000486456	ENST00000481707	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
5CDS-intron	ENST00000307546	ENST00000481707	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
5CDS-intron	ENST00000369611	ENST00000481707	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
5CDS-intron	ENST00000369615	ENST00000481707	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
5CDS-intron	ENST00000369617	ENST00000481707	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
In-frame	ENST00000307546	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
In-frame	ENST00000369611	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
In-frame	ENST00000369615	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+
In-frame	ENST00000369617	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000369617

MAGI3

chr1

114092253

ENST00000367460

RGS18

chr1

192150421

2404

718

285

1142

285

ENST00000307546

MAGI3

chr1

114092253

ENST00000367460

RGS18

chr1

192150421

2194

508

932

285

ENST00000369615

MAGI3

chr1

114092253

ENST00000367460

RGS18

chr1

192150421

2181

495

919

285

ENST00000369611

MAGI3

chr1

114092253

ENST00000367460

RGS18

chr1

192150421

2164

478

902

285

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369617	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+	0.000442223	0.9995578
ENST00000307546	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+	0.000401669	0.9995983
ENST00000369615	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+	0.000441551	0.9995584
ENST00000369611	ENST00000367460	MAGI3	chr1	114092253	+	RGS18	chr1	192150421	+	0.000447781	0.9995522

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Fusion Genomic Features for MAGI3-RGS18

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAGI3-RGS18

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:114092253/chr1:192150421)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAGI3 Q5TCQ9	.
FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269\|PubMed:10748157}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

6_9

144

1482.0

Compositional bias

Note=Poly-Lys

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

6_9

144

1126.0

Compositional bias

Note=Poly-Lys

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

6_9

144

2009.0

Compositional bias

Note=Poly-Lys

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

6_9

144

1151.0

Compositional bias

Note=Poly-Lys

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

121_128

144

1482.0

Nucleotide binding

ATP

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

121_128

144

1126.0

Nucleotide binding

ATP

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

121_128

144

2009.0

Nucleotide binding

ATP

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

121_128

144

1151.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

238_243

144

1482.0

Compositional bias

Note=Poly-Glu

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

238_243

144

1126.0

Compositional bias

Note=Poly-Glu

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

238_243

144

2009.0

Compositional bias

Note=Poly-Glu

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

238_243

144

1151.0

Compositional bias

Note=Poly-Glu

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

1021_1103

144

1482.0

Domain

PDZ 6

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

114_288

144

1482.0

Domain

Guanylate kinase-like

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

293_326

144

1482.0

Domain

WW 1

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

339_372

144

1482.0

Domain

WW 2

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000307546

578_654

144

1482.0

Domain

PDZ 3

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

1021_1103

144

1126.0

Domain

PDZ 6

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

114_288

144

1126.0

Domain

Guanylate kinase-like

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

293_326

144

1126.0

Domain

WW 1

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

339_372

144

1126.0

Domain

WW 2

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369611

578_654

144

1126.0

Domain

PDZ 3

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

1021_1103

144

2009.0

Domain

PDZ 6

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

114_288

144

2009.0

Domain

Guanylate kinase-like

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

293_326

144

2009.0

Domain

WW 1

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

339_372

144

2009.0

Domain

WW 2

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369615

578_654

144

2009.0

Domain

PDZ 3

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

1021_1103

144

1151.0

Domain

PDZ 6

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

114_288

144

1151.0

Domain

Guanylate kinase-like

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

293_326

144

1151.0

Domain

WW 1

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

339_372

144

1151.0

Domain

WW 2

Hgene

MAGI3

chr1:114092253

chr1:192150421

ENST00000369617

578_654

144

1151.0

Domain

PDZ 3

Tgene

RGS18

chr1:114092253

chr1:192150421

ENST00000367460

86_202

236.0

Domain

RGS

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Fusion Gene Sequence for MAGI3-RGS18

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50823_50823_1_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000307546_RGS18_chr1_192150421_ENST00000367460_length(transcript)=2194nt_BP=508nt
CCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTG
AAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGT
GGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCC
AGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGC
GAGCCCATCCGTCTCAAGACTGTGAAACCAGGCAAAGTCATTAATAAAGATTTGCGGCATTACCTAAGTCTTCAGTTTCAAAAAGGATCA
ATTGACCACAAACTGCAGCAAGTGATCAGAGATAATCTCTACTTGAGAACCATTCCATATGGACTAGAGGCTTTTACCAGATTTCTTAAA
ACTGAATTCAGTGAAGAAAATATTGAATTTTGGATAGCCTGTGAAGATTTCAAGAAAAGCAAGGGACCTCAACAAATTCACCTTAAAGCA
AAAGCAATATATGAGAAATTTATACAGACTGATGCCCCAAAAGAGGTTAACCTTGATTTTCACACAAAAGAAGTCATTACAAACAGCATC
ACTCAACCTACCCTCCACAGTTTTGATGCTGCACAAAGCAGAGTGTATCAGCTCATGGAACAAGACAGTTATACACGTTTTCTGAAATCT
GACATCTATTTAGACTTGATGGAAGGAAGACCTCAGAGACCAACAAATCTTAGGAGACGATCACGCTCATTTACCTGCAATGAATTCCAA
GATGTACAATCAGATGTTGCCATTTGGTTATAAAGAAAATTGATTTTGCTCATTTTTATGACAAACTTATACATCTGCTTCTAACATATC
GCATGTTTATGTTAAGATTTGGTCCCATCCTTTAAACTGAAATATGTCATGTGAAATTATTTTAAAAATGTAAAAACAAAACTTTCTGCT
AACAAAATACATACAGTATCTGCCAGTATATTCTGTAAAACCTTCTATTTGATGTCATTCCATTTATAATCAGAAAAAAAACTTATTTCT
TAATCAAAAGGCAGTACAAAAAAAGTAATAATGTTTTATAAGATTGTAGAGTTAAGTAAAAGTTAAGCTTTTGCAAAGTTGTCAAAAGTT
CAAACAAAAGTCTAGTTGGGATTTTTTACCAAAGCAGCATAATATGTGTTATATAAACATAATAATACTCAGATATCCAAATGTTCAGAT
AGCATTTTTCATAATGAATGTTCTCTTTTTTTTGGTAATAGTGTAGAAGTGATCTGGTTCTTACAATGGGAGATGAAGAACATTTATTAT
TGGGTTACTACTAACCCTGTCCCAAGAATAGTAATATCACCTCTAGTTATAAGCCAGCAACAGGAACTTTTGTGAAGACACATTCATCTC
TACAGAACTTCAGATTAAATATAATCTAGATTAATGACTGAGAATAAGATCCACATTTGAACTCATTCCTAAGTGAACATGGACGTACCC
AGTTATACAAAGTACTTCTGTTGGTCACAGAAACATGACCAGATTTTGCATATCTCCAGGTAGGGAACTAAGTAGACTACCTTATCACCG
GCTAAGAAAACTTGCTACTAAACTATTAGGCCATCAATGGCTTGAATAAAAACCAGAGAAGGTTTTTCCCAGGACGTCTCATGTTTGGCC
CTTTAGAATTGGGGTAGAAATCAGAAATGAGATGAGGGGAAGAAGCAAGGAGTCTAAGGCCCTAGCGATTTGGGCATCTGCCACATTGGT
TCATATTCAGAAAGTGTTATCTCATTGATTATATTCTTGTTAAGCAAATCTCCTTAAGTAATTATTATTCAAATAAGATTATACTCATAC
ATCTATATGTCACTGTTTTAAAGAGATATTTAATTTTTAATGTGTGTTACATGGTCTGTAAATATTTGTATTTAAAAATGCCATGCATTA
GGCTTTGGAAATTTAATGTTAGTTGAAATGTAAAATGTGAAAACTTTAGATCATTTGTAGTAATAAATATTTTTAACTTCATTCATACAG

>50823_50823_1_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000307546_RGS18_chr1_192150421_ENST00000367460_length(amino acids)=285AA_BP=145
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPYGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQ
IHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFT

--------------------------------------------------------------
>50823_50823_2_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000369611_RGS18_chr1_192150421_ENST00000367460_length(transcript)=2164nt_BP=478nt
CGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTG
CAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTG
GGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAAC
GGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCA
GGCAAAGTCATTAATAAAGATTTGCGGCATTACCTAAGTCTTCAGTTTCAAAAAGGATCAATTGACCACAAACTGCAGCAAGTGATCAGA
GATAATCTCTACTTGAGAACCATTCCATATGGACTAGAGGCTTTTACCAGATTTCTTAAAACTGAATTCAGTGAAGAAAATATTGAATTT
TGGATAGCCTGTGAAGATTTCAAGAAAAGCAAGGGACCTCAACAAATTCACCTTAAAGCAAAAGCAATATATGAGAAATTTATACAGACT
GATGCCCCAAAAGAGGTTAACCTTGATTTTCACACAAAAGAAGTCATTACAAACAGCATCACTCAACCTACCCTCCACAGTTTTGATGCT
GCACAAAGCAGAGTGTATCAGCTCATGGAACAAGACAGTTATACACGTTTTCTGAAATCTGACATCTATTTAGACTTGATGGAAGGAAGA
CCTCAGAGACCAACAAATCTTAGGAGACGATCACGCTCATTTACCTGCAATGAATTCCAAGATGTACAATCAGATGTTGCCATTTGGTTA
TAAAGAAAATTGATTTTGCTCATTTTTATGACAAACTTATACATCTGCTTCTAACATATCGCATGTTTATGTTAAGATTTGGTCCCATCC
TTTAAACTGAAATATGTCATGTGAAATTATTTTAAAAATGTAAAAACAAAACTTTCTGCTAACAAAATACATACAGTATCTGCCAGTATA
TTCTGTAAAACCTTCTATTTGATGTCATTCCATTTATAATCAGAAAAAAAACTTATTTCTTAATCAAAAGGCAGTACAAAAAAAGTAATA
ATGTTTTATAAGATTGTAGAGTTAAGTAAAAGTTAAGCTTTTGCAAAGTTGTCAAAAGTTCAAACAAAAGTCTAGTTGGGATTTTTTACC
AAAGCAGCATAATATGTGTTATATAAACATAATAATACTCAGATATCCAAATGTTCAGATAGCATTTTTCATAATGAATGTTCTCTTTTT
TTTGGTAATAGTGTAGAAGTGATCTGGTTCTTACAATGGGAGATGAAGAACATTTATTATTGGGTTACTACTAACCCTGTCCCAAGAATA
GTAATATCACCTCTAGTTATAAGCCAGCAACAGGAACTTTTGTGAAGACACATTCATCTCTACAGAACTTCAGATTAAATATAATCTAGA
TTAATGACTGAGAATAAGATCCACATTTGAACTCATTCCTAAGTGAACATGGACGTACCCAGTTATACAAAGTACTTCTGTTGGTCACAG
AAACATGACCAGATTTTGCATATCTCCAGGTAGGGAACTAAGTAGACTACCTTATCACCGGCTAAGAAAACTTGCTACTAAACTATTAGG
CCATCAATGGCTTGAATAAAAACCAGAGAAGGTTTTTCCCAGGACGTCTCATGTTTGGCCCTTTAGAATTGGGGTAGAAATCAGAAATGA
GATGAGGGGAAGAAGCAAGGAGTCTAAGGCCCTAGCGATTTGGGCATCTGCCACATTGGTTCATATTCAGAAAGTGTTATCTCATTGATT
ATATTCTTGTTAAGCAAATCTCCTTAAGTAATTATTATTCAAATAAGATTATACTCATACATCTATATGTCACTGTTTTAAAGAGATATT
TAATTTTTAATGTGTGTTACATGGTCTGTAAATATTTGTATTTAAAAATGCCATGCATTAGGCTTTGGAAATTTAATGTTAGTTGAAATG
TAAAATGTGAAAACTTTAGATCATTTGTAGTAATAAATATTTTTAACTTCATTCATACAGTTAAGTTTATCTGACAATAAAAGCTCTGAC

>50823_50823_2_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000369611_RGS18_chr1_192150421_ENST00000367460_length(amino acids)=285AA_BP=145
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPYGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQ
IHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFT

--------------------------------------------------------------
>50823_50823_3_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000369615_RGS18_chr1_192150421_ENST00000367460_length(transcript)=2181nt_BP=495nt
GGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGTGCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGC
ACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCCCCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTG
GCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGCACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATG
TGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGGGACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTC
TCAAGACTGTGAAACCAGGCAAAGTCATTAATAAAGATTTGCGGCATTACCTAAGTCTTCAGTTTCAAAAAGGATCAATTGACCACAAAC
TGCAGCAAGTGATCAGAGATAATCTCTACTTGAGAACCATTCCATATGGACTAGAGGCTTTTACCAGATTTCTTAAAACTGAATTCAGTG
AAGAAAATATTGAATTTTGGATAGCCTGTGAAGATTTCAAGAAAAGCAAGGGACCTCAACAAATTCACCTTAAAGCAAAAGCAATATATG
AGAAATTTATACAGACTGATGCCCCAAAAGAGGTTAACCTTGATTTTCACACAAAAGAAGTCATTACAAACAGCATCACTCAACCTACCC
TCCACAGTTTTGATGCTGCACAAAGCAGAGTGTATCAGCTCATGGAACAAGACAGTTATACACGTTTTCTGAAATCTGACATCTATTTAG
ACTTGATGGAAGGAAGACCTCAGAGACCAACAAATCTTAGGAGACGATCACGCTCATTTACCTGCAATGAATTCCAAGATGTACAATCAG
ATGTTGCCATTTGGTTATAAAGAAAATTGATTTTGCTCATTTTTATGACAAACTTATACATCTGCTTCTAACATATCGCATGTTTATGTT
AAGATTTGGTCCCATCCTTTAAACTGAAATATGTCATGTGAAATTATTTTAAAAATGTAAAAACAAAACTTTCTGCTAACAAAATACATA
CAGTATCTGCCAGTATATTCTGTAAAACCTTCTATTTGATGTCATTCCATTTATAATCAGAAAAAAAACTTATTTCTTAATCAAAAGGCA
GTACAAAAAAAGTAATAATGTTTTATAAGATTGTAGAGTTAAGTAAAAGTTAAGCTTTTGCAAAGTTGTCAAAAGTTCAAACAAAAGTCT
AGTTGGGATTTTTTACCAAAGCAGCATAATATGTGTTATATAAACATAATAATACTCAGATATCCAAATGTTCAGATAGCATTTTTCATA
ATGAATGTTCTCTTTTTTTTGGTAATAGTGTAGAAGTGATCTGGTTCTTACAATGGGAGATGAAGAACATTTATTATTGGGTTACTACTA
ACCCTGTCCCAAGAATAGTAATATCACCTCTAGTTATAAGCCAGCAACAGGAACTTTTGTGAAGACACATTCATCTCTACAGAACTTCAG
ATTAAATATAATCTAGATTAATGACTGAGAATAAGATCCACATTTGAACTCATTCCTAAGTGAACATGGACGTACCCAGTTATACAAAGT
ACTTCTGTTGGTCACAGAAACATGACCAGATTTTGCATATCTCCAGGTAGGGAACTAAGTAGACTACCTTATCACCGGCTAAGAAAACTT
GCTACTAAACTATTAGGCCATCAATGGCTTGAATAAAAACCAGAGAAGGTTTTTCCCAGGACGTCTCATGTTTGGCCCTTTAGAATTGGG
GTAGAAATCAGAAATGAGATGAGGGGAAGAAGCAAGGAGTCTAAGGCCCTAGCGATTTGGGCATCTGCCACATTGGTTCATATTCAGAAA
GTGTTATCTCATTGATTATATTCTTGTTAAGCAAATCTCCTTAAGTAATTATTATTCAAATAAGATTATACTCATACATCTATATGTCAC
TGTTTTAAAGAGATATTTAATTTTTAATGTGTGTTACATGGTCTGTAAATATTTGTATTTAAAAATGCCATGCATTAGGCTTTGGAAATT
TAATGTTAGTTGAAATGTAAAATGTGAAAACTTTAGATCATTTGTAGTAATAAATATTTTTAACTTCATTCATACAGTTAAGTTTATCTG

>50823_50823_3_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000369615_RGS18_chr1_192150421_ENST00000367460_length(amino acids)=285AA_BP=145
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPYGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQ
IHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFT

--------------------------------------------------------------
>50823_50823_4_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000369617_RGS18_chr1_192150421_ENST00000367460_length(transcript)=2404nt_BP=718nt
CTCCTGGGGACAATTCCCTTTTCCTTTCTTCAGCCTAACCCGCGGTGGCCCTCGCGGAGTCCGGTCAGCCCCGGGGAGCGCAGCCGGGAG
GGGCGTCCAAGGGGCGTCTCGCGTCTGGGAACGGCCGGGCCCCCAGCGGGCTGTGGTCGCGGGGTGGGGGCCGGAGCGGCGAGGCCCCCC
TTACCGGGCTGCGCGGGCCGCCCAGGGCCCCCGGGCTGAGACGGGGCCGGAGCGGCGCCCCGGCCGCCCGCGCGGGGTCTCCCCCATGGT
GCAGCGGGGTTCGGGATGTCGAAGACGCTGAAGAAGAAGAAGCACTGGCTCAGCAAGGTGCAGGAGTGCGCCGTGTCCTGGGCCGGGCCC
CCGGGCGACTTCGGCGCGGAGATCCGCGGTGGCGCGGAGCGTGGCGAGTTCCCCTACCTGGGGCGGCTCCGCGAGGAGCCCGGCGGGGGC
ACCTGCTGCGTCGTCTCGGGCAAGGCGCCCAGCCCAGGCGATGTGCTGCTGGAGGTAAACGGGACGCCTGTCAGCGGGCTCACCAACCGG
GACACCCTGGCTGTCATCCGCCACTTCCGCGAGCCCATCCGTCTCAAGACTGTGAAACCAGGCAAAGTCATTAATAAAGATTTGCGGCAT
TACCTAAGTCTTCAGTTTCAAAAAGGATCAATTGACCACAAACTGCAGCAAGTGATCAGAGATAATCTCTACTTGAGAACCATTCCATAT
GGACTAGAGGCTTTTACCAGATTTCTTAAAACTGAATTCAGTGAAGAAAATATTGAATTTTGGATAGCCTGTGAAGATTTCAAGAAAAGC
AAGGGACCTCAACAAATTCACCTTAAAGCAAAAGCAATATATGAGAAATTTATACAGACTGATGCCCCAAAAGAGGTTAACCTTGATTTT
CACACAAAAGAAGTCATTACAAACAGCATCACTCAACCTACCCTCCACAGTTTTGATGCTGCACAAAGCAGAGTGTATCAGCTCATGGAA
CAAGACAGTTATACACGTTTTCTGAAATCTGACATCTATTTAGACTTGATGGAAGGAAGACCTCAGAGACCAACAAATCTTAGGAGACGA
TCACGCTCATTTACCTGCAATGAATTCCAAGATGTACAATCAGATGTTGCCATTTGGTTATAAAGAAAATTGATTTTGCTCATTTTTATG
ACAAACTTATACATCTGCTTCTAACATATCGCATGTTTATGTTAAGATTTGGTCCCATCCTTTAAACTGAAATATGTCATGTGAAATTAT
TTTAAAAATGTAAAAACAAAACTTTCTGCTAACAAAATACATACAGTATCTGCCAGTATATTCTGTAAAACCTTCTATTTGATGTCATTC
CATTTATAATCAGAAAAAAAACTTATTTCTTAATCAAAAGGCAGTACAAAAAAAGTAATAATGTTTTATAAGATTGTAGAGTTAAGTAAA
AGTTAAGCTTTTGCAAAGTTGTCAAAAGTTCAAACAAAAGTCTAGTTGGGATTTTTTACCAAAGCAGCATAATATGTGTTATATAAACAT
AATAATACTCAGATATCCAAATGTTCAGATAGCATTTTTCATAATGAATGTTCTCTTTTTTTTGGTAATAGTGTAGAAGTGATCTGGTTC
TTACAATGGGAGATGAAGAACATTTATTATTGGGTTACTACTAACCCTGTCCCAAGAATAGTAATATCACCTCTAGTTATAAGCCAGCAA
CAGGAACTTTTGTGAAGACACATTCATCTCTACAGAACTTCAGATTAAATATAATCTAGATTAATGACTGAGAATAAGATCCACATTTGA
ACTCATTCCTAAGTGAACATGGACGTACCCAGTTATACAAAGTACTTCTGTTGGTCACAGAAACATGACCAGATTTTGCATATCTCCAGG
TAGGGAACTAAGTAGACTACCTTATCACCGGCTAAGAAAACTTGCTACTAAACTATTAGGCCATCAATGGCTTGAATAAAAACCAGAGAA
GGTTTTTCCCAGGACGTCTCATGTTTGGCCCTTTAGAATTGGGGTAGAAATCAGAAATGAGATGAGGGGAAGAAGCAAGGAGTCTAAGGC
CCTAGCGATTTGGGCATCTGCCACATTGGTTCATATTCAGAAAGTGTTATCTCATTGATTATATTCTTGTTAAGCAAATCTCCTTAAGTA
ATTATTATTCAAATAAGATTATACTCATACATCTATATGTCACTGTTTTAAAGAGATATTTAATTTTTAATGTGTGTTACATGGTCTGTA
AATATTTGTATTTAAAAATGCCATGCATTAGGCTTTGGAAATTTAATGTTAGTTGAAATGTAAAATGTGAAAACTTTAGATCATTTGTAG

>50823_50823_4_MAGI3-RGS18_MAGI3_chr1_114092253_ENST00000369617_RGS18_chr1_192150421_ENST00000367460_length(amino acids)=285AA_BP=145
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAV
IRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPYGLEAFTRFLKTEFSEENIEFWIACEDFKKSKGPQQ
IHLKAKAIYEKFIQTDAPKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYTRFLKSDIYLDLMEGRPQRPTNLRRRSRSFT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAGI3-RGS18

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000307546	+	2	21	18_106	144.33333333333334	1482.0	ADRB1 and TGFA
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369611	+	2	21	18_106	144.33333333333334	1126.0	ADRB1 and TGFA
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369615	+	2	22	18_106	144.33333333333334	2009.0	ADRB1 and TGFA
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369617	+	2	22	18_106	144.33333333333334	1151.0	ADRB1 and TGFA

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000307546	+	2	21	726_808	144.33333333333334	1482.0	ADGRB1
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369611	+	2	21	726_808	144.33333333333334	1126.0	ADGRB1
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369615	+	2	22	726_808	144.33333333333334	2009.0	ADGRB1
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369617	+	2	22	726_808	144.33333333333334	1151.0	ADGRB1
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000307546	+	2	21	851_938	144.33333333333334	1482.0	LPAR2 and GRIN2B
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369611	+	2	21	851_938	144.33333333333334	1126.0	LPAR2 and GRIN2B
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369615	+	2	22	851_938	144.33333333333334	2009.0	LPAR2 and GRIN2B
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369617	+	2	22	851_938	144.33333333333334	1151.0	LPAR2 and GRIN2B
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000307546	+	2	21	410_492	144.33333333333334	1482.0	PTEN
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369611	+	2	21	410_492	144.33333333333334	1126.0	PTEN
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369615	+	2	22	410_492	144.33333333333334	2009.0	PTEN
Hgene	MAGI3	chr1:114092253	chr1:192150421	ENST00000369617	+	2	22	410_492	144.33333333333334	1151.0	PTEN

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MAGI3-RGS18

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MAGI3-RGS18

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source