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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAG-NMNAT3 (FusionGDB2 ID:50826)

Fusion Gene Summary for MAG-NMNAT3

check button Fusion gene summary
Fusion gene informationFusion gene name: MAG-NMNAT3
Fusion gene ID: 50826
HgeneTgene
Gene symbol

MAG

NMNAT3

Gene ID

4099

349565

Gene namemyelin associated glycoproteinnicotinamide nucleotide adenylyltransferase 3
SynonymsGMA|S-MAG|SIGLEC-4A|SIGLEC4A|SPG75FKSG76|PNAT-3|PNAT3
Cytomap

19q13.12

3q23

Type of geneprotein-codingprotein-coding
Descriptionmyelin-associated glycoproteinsialic acid binding Ig-like lectin 4Asialic acid-binding immunoglobulin-like lectin 4Anicotinamide/nicotinic acid mononucleotide adenylyltransferase 3NMN adenylyltransferase 3NMN/NaMN adenylyltransferase 3NaMN adenylyltransferase 3nicotinamide mononucleotide adenylyltransferase 3nicotinate-nucleotide adenylyltransferase 3pyridine nuc
Modification date2020031320200313
UniProtAcc

P20916

Q96T66

Ensembl transtripts involved in fusion geneENST00000361922, ENST00000392213, 
ENST00000597035, ENST00000537831, 
ENST00000593348, 		ENST00000296202, 
ENST00000339837, ENST00000406164, 
ENST00000406824, ENST00000413939, 
ENST00000512391, ENST00000507242, 
ENST00000511444, ENST00000514703, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 5 X 5=175
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAG [Title/Abstract] AND NMNAT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAG(35786353)-NMNAT3(139396595), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NMNAT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM544763MAGchr19

35786353

+NMNAT3chr3

139396595

-


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Fusion Gene ORF analysis for MAG-NMNAT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361922ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000361922ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000392213ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-5UTRENST00000597035ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000361922ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000361922ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000361922ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000392213ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000392213ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000392213ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000597035ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000597035ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
5CDS-intronENST00000597035ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000537831ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000296202MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000339837MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000406164MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000406824MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000413939MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-5UTRENST00000593348ENST00000512391MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000537831ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000537831ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000537831ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000593348ENST00000507242MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000593348ENST00000511444MAGchr19

35786353

+NMNAT3chr3

139396595

-
intron-intronENST00000593348ENST00000514703MAGchr19

35786353

+NMNAT3chr3

139396595

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAG-NMNAT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAG-NMNAT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35786353/:139396595)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAG

P20916

NMNAT3

Q96T66

FUNCTION: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity). {ECO:0000250|UniProtKB:P07722, ECO:0000250|UniProtKB:P20917}.FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAG-NMNAT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAG-NMNAT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAG-NMNAT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAG-NMNAT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource