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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAK16-ANGPT2 (FusionGDB2 ID:50836)

Fusion Gene Summary for MAK16-ANGPT2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAK16-ANGPT2
Fusion gene ID: 50836
HgeneTgene
Gene symbol

MAK16

ANGPT2

Gene ID

84549

285

Gene nameMAK16 homologangiopoietin 2
SynonymsMAK16L|RBM13AGPT2|ANG2
Cytomap

8p12

8p23.1

Type of geneprotein-codingprotein-coding
Descriptionprotein MAK16 homologNNP78RNA binding motif protein 13RNA binding proteinangiopoietin-2ANG-2Tie2-ligandangiopoietin-2Bangiopoietin-2a
Modification date2020032720200327
UniProtAcc

Q9BXY0

.
Ensembl transtripts involved in fusion geneENST00000360128, ENST00000338312, 
ENST00000523120, ENST00000325203, 
ENST00000415216, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAK16 [Title/Abstract] AND ANGPT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAK16(33347857)-ANGPT2(6390008), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANGPT2

GO:0043537

negative regulation of blood vessel endothelial cell migration

9660821

TgeneANGPT2

GO:0048014

Tie signaling pathway

19922791

TgeneANGPT2

GO:0050928

negative regulation of positive chemotaxis

9660821


check buttonFusion gene breakpoints across MAK16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANGPT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TT-01AMAK16chr8

33347857

-ANGPT2chr8

6390008

-
ChimerDB4BRCATCGA-AR-A0TT-01AMAK16chr8

33347857

+ANGPT2chr8

6390008

-


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Fusion Gene ORF analysis for MAK16-ANGPT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360128ENST00000338312MAK16chr8

33347857

+ANGPT2chr8

6390008

-
5CDS-intronENST00000360128ENST00000523120MAK16chr8

33347857

+ANGPT2chr8

6390008

-
In-frameENST00000360128ENST00000325203MAK16chr8

33347857

+ANGPT2chr8

6390008

-
In-frameENST00000360128ENST00000415216MAK16chr8

33347857

+ANGPT2chr8

6390008

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360128MAK16chr833347857+ENST00000325203ANGPT2chr86390008-55579044572106549
ENST00000360128MAK16chr833347857+ENST00000415216ANGPT2chr86390008-55319044572103548

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360128ENST00000325203MAK16chr833347857+ANGPT2chr86390008-0.0007424760.9992575
ENST00000360128ENST00000415216MAK16chr833347857+ANGPT2chr86390008-0.0007813720.9992186

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Fusion Genomic Features for MAK16-ANGPT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAK16-ANGPT2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:33347857/chr8:6390008)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAK16

Q9BXY0

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANGPT2chr8:33347857chr8:6390008ENST0000032520309166_24896497.0Coiled coilOntology_term=ECO:0000255
TgeneANGPT2chr8:33347857chr8:6390008ENST0000033831208166_2480445.0Coiled coilOntology_term=ECO:0000255
TgeneANGPT2chr8:33347857chr8:6390008ENST0000041521609166_24896496.0Coiled coilOntology_term=ECO:0000255
TgeneANGPT2chr8:33347857chr8:6390008ENST0000032520309275_49596497.0DomainFibrinogen C-terminal
TgeneANGPT2chr8:33347857chr8:6390008ENST0000033831208275_4950445.0DomainFibrinogen C-terminal
TgeneANGPT2chr8:33347857chr8:6390008ENST0000041521609275_49596496.0DomainFibrinogen C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAK16chr8:33347857chr8:6390008ENST00000360128+610198_249149301.0Compositional biasNote=Asp-rich
HgeneMAK16chr8:33347857chr8:6390008ENST00000360128+610255_259149301.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for MAK16-ANGPT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50836_50836_1_MAK16-ANGPT2_MAK16_chr8_33347857_ENST00000360128_ANGPT2_chr8_6390008_ENST00000325203_length(transcript)=5557nt_BP=904nt
GGAGCGGGGACCCAGCCCCGCCGCGCCGCCTGCAGCTTTCCCCAGCCTCCTCCCAGCAGAGGGGAGGCCCGACAGGGAGGGGTCCCATCC
TCATGAACGGTCACAAACAGGGCGCTAGGGAAGCACGCCCGACCCCCGCGGTCCCCGCGCTCCAGGATTCGGCAGACTGCGCGCGTCCTG
CCTCCCGCGGATCGCACTGGGTCCCAACAGGGTTCCCAGCTCCAGGCTGCGCCCATGAACAAGCCCAGCATTGCGGACGGGCGCGCGCAG
ACGCCAGCGTGGTGAAGACGCGGGGGCGCGCGCGCGGCGACGAGACTGCCAGGGGACGCTTCGCAACACCGAGAGTCTCAGCGTTTCTCG
AGATAGGTGAGGCTGCGCGTTCCGGAACTGGTTTCCCGGAAGGAGCATGTCTGCGCCCGCGATCCGACCGGAAGTTGCACGCTGAGCCGC
GGACACCATGCAGTCGGATGATGTTATCTGGGATACACTAGGAAACAAGCAATTTTGTTCCTTCAAAATAAGAACCAAGACTCAGAGCTT
CTGCCGAAATGAATATAGCCTGACTGGACTGTGTAATCGGTCATCCTGTCCCCTGGCAAATAGTCAGTATGCCACTATTAAAGAAGAGAA
AGGACAGTGCTACTTGTATATGAAGGTTATAGAACGAGCGGCTTTTCCTCGGCGTCTCTGGGAACGGGTCCGGCTTAGTAAAAACTATGA
GAAAGCACTGGAGCAAATAGATGAAAATCTGATTTACTGGCCCCGTTTCATTCGACACAAATGTAAGCAGAGATTCACCAAGATCACCCA
ATACCTAATTCGAATTAGAAAACTTACACTAAAGCGACAGAGGAAACTTGTTCCTTTGAGTAAGAAGGTGGAGCGTAGGGAGAAAAGAAG
AGAGCTTGAGAATTATATCCAGGACAACATGAAGAAAGAAATGGTAGAGATACAGCAGAATGCAGTACAGAACCAGACGGCTGTGATGAT
AGAAATAGGGACAAACCTGTTGAACCAAACAGCGGAGCAAACGCGGAAGTTAACTGATGTGGAAGCCCAAGTATTAAATCAGACCACGAG
ACTTGAACTTCAGCTCTTGGAACACTCCCTCTCGACAAACAAATTGGAAAAACAGATTTTGGACCAGACCAGTGAAATAAACAAATTGCA
AGATAAGAACAGTTTCCTAGAAAAGAAGGTGCTAGCTATGGAAGACAAGCACATCATCCAACTACAGTCAATAAAAGAAGAGAAAGATCA
GCTACAGGTGTTAGTATCCAAGCAAAATTCCATCATTGAAGAACTAGAAAAAAAAATAGTGACTGCCACGGTGAATAATTCAGTTCTTCA
GAAGCAGCAACATGATCTCATGGAGACAGTTAATAACTTACTGACTATGATGTCCACATCAAACTCAGCTAAGGACCCCACTGTTGCTAA
AGAAGAACAAATCAGCTTCAGAGACTGTGCTGAAGTATTCAAATCAGGACACACCACGAATGGCATCTACACGTTAACATTCCCTAATTC
TACAGAAGAGATCAAGGCCTACTGTGACATGGAAGCTGGAGGAGGCGGGTGGACAATTATTCAGCGACGTGAGGATGGCAGCGTTGATTT
TCAGAGGACTTGGAAAGAATATAAAGTGGGATTTGGTAACCCTTCAGGAGAATATTGGCTGGGAAATGAGTTTGTTTCGCAACTGACTAA
TCAGCAACGCTATGTGCTTAAAATACACCTTAAAGACTGGGAAGGGAATGAGGCTTACTCATTGTATGAACATTTCTATCTCTCAAGTGA
AGAACTCAATTATAGGATTCACCTTAAAGGACTTACAGGGACAGCCGGCAAAATAAGCAGCATCAGCCAACCAGGAAATGATTTTAGCAC
AAAGGATGGAGACAACGACAAATGTATTTGCAAATGTTCACAAATGCTAACAGGAGGCTGGTGGTTTGATGCATGTGGTCCTTCCAACTT
GAACGGAATGTACTATCCACAGAGGCAGAACACAAATAAGTTCAACGGCATTAAATGGTACTACTGGAAAGGCTCAGGCTATTCGCTCAA
GGCCACAACCATGATGATCCGACCAGCAGATTTCTAAACATCCCAGTCCACCTGAGGAACTGTCTCGAACTATTTTCAAAGACTTAAGCC
CAGTGCACTGAAAGTCACGGCTGCGCACTGTGTCCTCTTCCACCACAGAGGGCGTGTGCTCGGTGCTGACGGGACCCACATGCTCCAGAT
TAGAGCCTGTAAACTTTATCACTTAAACTTGCATCACTTAACGGACCAAAGCAAGACCCTAAACATCCATAATTGTGATTAGACAGAACA
CCTATGCAAAGATGAACCCGAGGCTGAGAATCAGACTGACAGTTTACAGACGCTGCTGTCACAACCAAGAATGTTATGTGCAAGTTTATC
AGTAAATAACTGGAAAACAGAACACTTATGTTATACAATACAGATCATCTTGGAACTGCATTCTTCTGAGCACTGTTTATACACTGTGTA
AATACCCATATGTCCTGAATTCACCATCACTATCACAATTAAAAGGAAGAAAAAAACTCTCTAAGCCATAAAAAGACATATTCAGGGATA
TTCTGAGAAGGGGTTACTAGAAGTTTAATATTTGGAAAAACAGTTAGTGCATTTTTACTCCATCTCTTAGGTGCTTTAAATTTTTATTTC
AAAAACAGCGTATTTACATTTATGTTGACAGCTTAGTTATAAGTTAATGCTCAAATACGTATTTCAAATTTATATGGTAGAAACTTCCAG
AATCTCTGAAATTATCAACAGAAACGTGCCATTTTAGTTTATATGCAGACCGTACTATTTTTTTCTGCCTGATTGTTAAATATGAAGGTA
TTTTTAGTAATTAAATATAACTTATTAGGGGATATGCCTATGTTTAACTTTTATGATAATATTTACAATTTTATAATTTGTTTCCAAAAG
ACCTAATTGTGCCTTGTGATAAGGAAACTTCTTACTTTTAATGATGAGGAAAATTATACATTTCATTCTATGACAAAGAAACTTTACTAT
CTTCTCACTATTCTAAAACAGAGGTCTGTTTTCTTTCCTAGTAAGATATATTTTTATAGAACTAGACTACAATTTAATTTCTGGTTGAGA
AAAGCCTTCTATTTAAGAAATTTACAAAGCTATATGTCTCAAGATTCACCCTTAAATTTACTTAAGGAAAAAAATAATTGACACTAGTAA
GTTTTTTTATGTCAATCAGCAAACTGAAAAAAAAAAAAGGGTTTCAAAGTGCAAAAACAAAATCTGATGTTCATAATATATTTAAATATT
TACCAAAAATTTGAGAACACAGGGCTGGGCGCAGTGGCTCACACCTATAATCCCAGTACATTGGTAGGCAAGGTGGGCAGATCACCTGAG
GTCAGGAGTTCAAGACCAGCCTGGACAACATGGTGAAACCCTGTCTCTACTAAATAATACAAAAATTAGCCAGGCGTGCTGGCGGGCACC
TGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGGAGAATTGCTTGCACCAGGGAGGTAGAGGTTGCAGTGAGCCAAGATCGCACCACTGC
ACTCCAGCCGGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAGAAAGAAAAGAAAATTTGAGAACACAGCTTTATACT
CGGGACTACAAAACCATAAACTCCTGGAGTTTTAACTCCTTTTGAAATTTTCATAGTACAATTAATACTAATGAACATTTGTGTAAAGCT
TTATAATTTAAAGGCAATTTCTCATATATTCTTTTCTGAATCATTTGCAAGGAAGTTCAGAGTCCAGTCTGTAACTAGCATCTACTATAT
GTCTGTCTTCACCTTACAGTGTTCTACCATTATTTTTTCTTTATTCCATTTCAAAATCTAATTTATTTTACCCCAACTTCTCCCCACCAC
TTGACGTAGTTTTAGAACACACAGGTGTTGCTACATATTTGGAGTCAATGATGGACTCTGGCAAAGTCAAGGCTCTGTTTTATTTCCACC
AAGGTGCACTTTTCCAACAACTATTTAACTAGTTAAGAACCTCCCTATCTTAGAACTGTATCTACTTTATATTTAAGAAGGTTTTATGAA
TTCAACAACGGTATCATGGCCTTGTATCAAGTTGAAAAACAACTGAAAATAAGAAAATTTCACAGCCTCGAAAGACAACAACAAGTTTCT
AGGATATCTCAATGACAAGAGTGATGGATACTTAGGTAGGGAAACGCTAATGCAGGAAAAACTGGCAACAACACAATTTATATCAATTCT
CTTTGTAGGCAGGTGATAAAAAATTCAAGGACAAATCTCATTATGTCATTGTGCATCATATATAATCTCTTATGAGCGAGAATGGGGGGA
ATTTGTGTTTTTACTTTACACTTCAATTCCTTACACGGTATTTCAAACAAACAGTTTTGCTGAGAGGAGCTTTTGTCTCTCCTTAAGAAA
ATGTTTATAAAGCTGAAAGGAAATCAAACAGTAATCTTAAAAATGAAAACAAAACAACCCAACAACCTAGATAACTACAGTGATCAGGGA
GCACAGTTCAACTCCTTGTTATGTTTTAGTCATATGGCCTACTCAAACAGCTAAATAACAACACCAGTGGCAGATAAAAATCACCATTTA
TCTTTCAGCTATTAATCTTTTGAATGAATAAACTGTGACAAACAAATTAACATTTTTGAACATGAAAGGCAACTTCTGCACAATCCTGTA
TCCAAGCAAACTTTAAATTATCCACTTAATTATTACTTAATCTTAAAAAAAATTAGAACCCAGAACTTTTCAATGAAGCATTTGAAAGTT
GAAGTGGAATTTAGGAAAGCCATAAAAATATAAATACTGTTATCACAGCACCAGCAAGCCATAATCTTTATACCTATCAGTTCTATTTCT
ATTAACAGTAAAAACATTAAGCAAGATATAAGACTACCTGCCCAAGAATTCAGTCTTTTTTCATTTTTGTTTTTCTCAGTTCTGAGGATG
TTAATCGTCAAATTTTCTTTGGACTGCATTCCTCACTACTTTTTGCACAATGGTCTCACGTTCTCACATTTGTTCTCGCGAATAAATTGA
TAAAAGGTGTTAAGTTCTGTGAATGTCTTTTTAATTATGGGCATAATTGTGCTTGACTGGATAAAAACTTAAGTCCACCCTTATGTTTAT
AATAATTTCTTGAGAACAGCAAACTGCATTTACCATCGTAAAACAACATCTGACTTACGGGAGCTGCAGGGAAGTGGTGAGACAGTTCGA
ACGGCTCCTCAGAAATCCAGTGACCCAATTCTAAAGACCATAGCACCTGCAAGTGACACAACAAGCAGATTTATTATACATTTATTAGCC
TTAGCAGGCAATAAACCAAGAATCACTTTGAAGACACAGCAAAAAGTGATACACTCCGCAGATCTGAAATAGATGTGTTCTCAGACAACA

>50836_50836_1_MAK16-ANGPT2_MAK16_chr8_33347857_ENST00000360128_ANGPT2_chr8_6390008_ENST00000325203_length(amino acids)=549AA_BP=139
MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLSKNYEKA
LEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRRELENYIQDNMKKEMVEIQQNAVQNQTAVMIEI
GTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQ
VLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTE
EIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEEL
NYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKAT

--------------------------------------------------------------
>50836_50836_2_MAK16-ANGPT2_MAK16_chr8_33347857_ENST00000360128_ANGPT2_chr8_6390008_ENST00000415216_length(transcript)=5531nt_BP=904nt
GGAGCGGGGACCCAGCCCCGCCGCGCCGCCTGCAGCTTTCCCCAGCCTCCTCCCAGCAGAGGGGAGGCCCGACAGGGAGGGGTCCCATCC
TCATGAACGGTCACAAACAGGGCGCTAGGGAAGCACGCCCGACCCCCGCGGTCCCCGCGCTCCAGGATTCGGCAGACTGCGCGCGTCCTG
CCTCCCGCGGATCGCACTGGGTCCCAACAGGGTTCCCAGCTCCAGGCTGCGCCCATGAACAAGCCCAGCATTGCGGACGGGCGCGCGCAG
ACGCCAGCGTGGTGAAGACGCGGGGGCGCGCGCGCGGCGACGAGACTGCCAGGGGACGCTTCGCAACACCGAGAGTCTCAGCGTTTCTCG
AGATAGGTGAGGCTGCGCGTTCCGGAACTGGTTTCCCGGAAGGAGCATGTCTGCGCCCGCGATCCGACCGGAAGTTGCACGCTGAGCCGC
GGACACCATGCAGTCGGATGATGTTATCTGGGATACACTAGGAAACAAGCAATTTTGTTCCTTCAAAATAAGAACCAAGACTCAGAGCTT
CTGCCGAAATGAATATAGCCTGACTGGACTGTGTAATCGGTCATCCTGTCCCCTGGCAAATAGTCAGTATGCCACTATTAAAGAAGAGAA
AGGACAGTGCTACTTGTATATGAAGGTTATAGAACGAGCGGCTTTTCCTCGGCGTCTCTGGGAACGGGTCCGGCTTAGTAAAAACTATGA
GAAAGCACTGGAGCAAATAGATGAAAATCTGATTTACTGGCCCCGTTTCATTCGACACAAATGTAAGCAGAGATTCACCAAGATCACCCA
ATACCTAATTCGAATTAGAAAACTTACACTAAAGCGACAGAGGAAACTTGTTCCTTTGAGTAAGAAGGTGGAGCGTAGGGAGAAAAGAAG
AGAGCTTGAGAATTATATCCAGGACAACATGAAGAAAGAAATGGTAGAGATACAGCAGAATGCAGTACAGAACCAGACGGCTGTGATGAT
AGAAATAGGGACAAACCTGTTGAACCAAACAGCGGAGCAAACGCGGAAGTTAACTGATGTGGAAGCCCAAGTATTAAATCAGACCACGAG
ACTTGAACTTCAGCTCTTGGAACACTCCCTCTCGACAAACAAATTGGAAAAACAGATTTTGGACCAGACCAGTGAAATAAACAAATTGCA
AGATAAGAACAGTTTCCTAGAAAAGAAGGTGCTAGCTATGGAAGACAAGCACATCATCCAACTACAGTCAATAAAAGAAGAGAAAGATCA
GCTACAGGTGTTAGTATCCAAGCAAAATTCCATCATTGAAGAACTAGAAAAAAAAATAGTGACTGCCACGGTGAATAATTCAGTTCTTCA
GAAGCAGCAACATGATCTCATGGAGACAGTTAATAACTTACTGACTATGATGTCCACATCAAACTCTAAGGACCCCACTGTTGCTAAAGA
AGAACAAATCAGCTTCAGAGACTGTGCTGAAGTATTCAAATCAGGACACACCACGAATGGCATCTACACGTTAACATTCCCTAATTCTAC
AGAAGAGATCAAGGCCTACTGTGACATGGAAGCTGGAGGAGGCGGGTGGACAATTATTCAGCGACGTGAGGATGGCAGCGTTGATTTTCA
GAGGACTTGGAAAGAATATAAAGTGGGATTTGGTAACCCTTCAGGAGAATATTGGCTGGGAAATGAGTTTGTTTCGCAACTGACTAATCA
GCAACGCTATGTGCTTAAAATACACCTTAAAGACTGGGAAGGGAATGAGGCTTACTCATTGTATGAACATTTCTATCTCTCAAGTGAAGA
ACTCAATTATAGGATTCACCTTAAAGGACTTACAGGGACAGCCGGCAAAATAAGCAGCATCAGCCAACCAGGAAATGATTTTAGCACAAA
GGATGGAGACAACGACAAATGTATTTGCAAATGTTCACAAATGCTAACAGGAGGCTGGTGGTTTGATGCATGTGGTCCTTCCAACTTGAA
CGGAATGTACTATCCACAGAGGCAGAACACAAATAAGTTCAACGGCATTAAATGGTACTACTGGAAAGGCTCAGGCTATTCGCTCAAGGC
CACAACCATGATGATCCGACCAGCAGATTTCTAAACATCCCAGTCCACCTGAGGAACTGTCTCGAACTATTTTCAAAGACTTAAGCCCAG
TGCACTGAAAGTCACGGCTGCGCACTGTGTCCTCTTCCACCACAGAGGGCGTGTGCTCGGTGCTGACGGGACCCACATGCTCCAGATTAG
AGCCTGTAAACTTTATCACTTAAACTTGCATCACTTAACGGACCAAAGCAAGACCCTAAACATCCATAATTGTGATTAGACAGAACACCT
ATGCAAAGATGAACCCGAGGCTGAGAATCAGACTGACAGTTTACAGACGCTGCTGTCACAACCAAGAATGTTATGTGCAAGTTTATCAGT
AAATAACTGGAAAACAGAACACTTATGTTATACAATACAGATCATCTTGGAACTGCATTCTTCTGAGCACTGTTTATACACTGTGTAAAT
ACCCATATGTCCTGAATTCACCATCACTATCACAATTAAAAGGAAGAAAAAAACTCTCTAAGCCATAAAAAGACATATTCAGGGATATTC
TGAGAAGGGGTTACTAGAAGTTTAATATTTGGAAAAACAGTTAGTGCATTTTTACTCCATCTCTTAGGTGCTTTAAATTTTTATTTCAAA
AACAGCGTATTTACATTTATGTTGACAGCTTAGTTATAAGTTAATGCTCAAATACGTATTTCAAATTTATATGGTAGAAACTTCCAGAAT
CTCTGAAATTATCAACAGAAACGTGCCATTTTAGTTTATATGCAGACCGTACTATTTTTTTCTGCCTGATTGTTAAATATGAAGGTATTT
TTAGTAATTAAATATAACTTATTAGGGGATATGCCTATGTTTAACTTTTATGATAATATTTACAATTTTATAATTTGTTTCCAAAAGACC
TAATTGTGCCTTGTGATAAGGAAACTTCTTACTTTTAATGATGAGGAAAATTATACATTTCATTCTATGACAAAGAAACTTTACTATCTT
CTCACTATTCTAAAACAGAGGTCTGTTTTCTTTCCTAGTAAGATATATTTTTATAGAACTAGACTACAATTTAATTTCTGGTTGAGAAAA
GCCTTCTATTTAAGAAATTTACAAAGCTATATGTCTCAAGATTCACCCTTAAATTTACTTAAGGAAAAAAATAATTGACACTAGTAAGTT
TTTTTATGTCAATCAGCAAACTGAAAAAAAAAAAAGGGTTTCAAAGTGCAAAAACAAAATCTGATGTTCATAATATATTTAAATATTTAC
CAAAAATTTGAGAACACAGGGCTGGGCGCAGTGGCTCACACCTATAATCCCAGTACATTGGTAGGCAAGGTGGGCAGATCACCTGAGGTC
AGGAGTTCAAGACCAGCCTGGACAACATGGTGAAACCCTGTCTCTACTAAATAATACAAAAATTAGCCAGGCGTGCTGGCGGGCACCTGT
AATCCCAGCTACTCGGGAGGCTGAGGCAGGGAGAATTGCTTGCACCAGGGAGGTAGAGGTTGCAGTGAGCCAAGATCGCACCACTGCACT
CCAGCCGGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAGAAAGAAAAGAAAATTTGAGAACACAGCTTTATACTCGG
GACTACAAAACCATAAACTCCTGGAGTTTTAACTCCTTTTGAAATTTTCATAGTACAATTAATACTAATGAACATTTGTGTAAAGCTTTA
TAATTTAAAGGCAATTTCTCATATATTCTTTTCTGAATCATTTGCAAGGAAGTTCAGAGTCCAGTCTGTAACTAGCATCTACTATATGTC
TGTCTTCACCTTACAGTGTTCTACCATTATTTTTTCTTTATTCCATTTCAAAATCTAATTTATTTTACCCCAACTTCTCCCCACCACTTG
ACGTAGTTTTAGAACACACAGGTGTTGCTACATATTTGGAGTCAATGATGGACTCTGGCAAAGTCAAGGCTCTGTTTTATTTCCACCAAG
GTGCACTTTTCCAACAACTATTTAACTAGTTAAGAACCTCCCTATCTTAGAACTGTATCTACTTTATATTTAAGAAGGTTTTATGAATTC
AACAACGGTATCATGGCCTTGTATCAAGTTGAAAAACAACTGAAAATAAGAAAATTTCACAGCCTCGAAAGACAACAACAAGTTTCTAGG
ATATCTCAATGACAAGAGTGATGGATACTTAGGTAGGGAAACGCTAATGCAGGAAAAACTGGCAACAACACAATTTATATCAATTCTCTT
TGTAGGCAGGTGATAAAAAATTCAAGGACAAATCTCATTATGTCATTGTGCATCATATATAATCTCTTATGAGCGAGAATGGGGGGAATT
TGTGTTTTTACTTTACACTTCAATTCCTTACACGGTATTTCAAACAAACAGTTTTGCTGAGAGGAGCTTTTGTCTCTCCTTAAGAAAATG
TTTATAAAGCTGAAAGGAAATCAAACAGTAATCTTAAAAATGAAAACAAAACAACCCAACAACCTAGATAACTACAGTGATCAGGGAGCA
CAGTTCAACTCCTTGTTATGTTTTAGTCATATGGCCTACTCAAACAGCTAAATAACAACACCAGTGGCAGATAAAAATCACCATTTATCT
TTCAGCTATTAATCTTTTGAATGAATAAACTGTGACAAACAAATTAACATTTTTGAACATGAAAGGCAACTTCTGCACAATCCTGTATCC
AAGCAAACTTTAAATTATCCACTTAATTATTACTTAATCTTAAAAAAAATTAGAACCCAGAACTTTTCAATGAAGCATTTGAAAGTTGAA
GTGGAATTTAGGAAAGCCATAAAAATATAAATACTGTTATCACAGCACCAGCAAGCCATAATCTTTATACCTATCAGTTCTATTTCTATT
AACAGTAAAAACATTAAGCAAGATATAAGACTACCTGCCCAAGAATTCAGTCTTTTTTCATTTTTGTTTTTCTCAGTTCTGAGGATGTTA
ATCGTCAAATTTTCTTTGGACTGCATTCCTCACTACTTTTTGCACAATGGTCTCACGTTCTCACATTTGTTCTCGCGAATAAATTGATAA
AAGGTGTTAAGTTCTGTGAATGTCTTTTTAATTATGGGCATAATTGTGCTTGACTGGATAAAAACTTAAGTCCACCCTTATGTTTATAAT
AATTTCTTGAGAACAGCAAACTGCATTTACCATCGTAAAACAACATCTGACTTACGGGAGCTGCAGGGAAGTGGTGAGACAGTTCGAACG
GCTCCTCAGAAATCCAGTGACCCAATTCTAAAGACCATAGCACCTGCAAGTGACACAACAAGCAGATTTATTATACATTTATTAGCCTTA
GCAGGCAATAAACCAAGAATCACTTTGAAGACACAGCAAAAAGTGATACACTCCGCAGATCTGAAATAGATGTGTTCTCAGACAACAAAG

>50836_50836_2_MAK16-ANGPT2_MAK16_chr8_33347857_ENST00000360128_ANGPT2_chr8_6390008_ENST00000415216_length(amino acids)=548AA_BP=139
MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSCPLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLSKNYEKA
LEQIDENLIYWPRFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRRELENYIQDNMKKEMVEIQQNAVQNQTAVMIEI
GTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQ
VLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEE
IKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELN
YRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATT

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Fusion Gene PPI Analysis for MAK16-ANGPT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAK16-ANGPT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAK16-ANGPT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource