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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:MAL-KRT4 (FusionGDB2 ID:50959)

Fusion Gene Summary for MAL-KRT4

Fusion gene summary

Fusion gene information	Fusion gene name: MAL-KRT4
	Fusion gene ID: 50959
		Hgene	Tgene
	Gene symbol	MAL	KRT4
	Gene ID	57591	3851
	Gene name	myocardin related transcription factor A	keratin 4
	Synonyms	BSAC\|MAL\|MKL\|MKL1\|MRTF-A	CK-4\|CK4\|CYK4\|K4\|WSN1
	Cytomap	22q13.1-q13.2	12q13.13
	Type of gene	protein-coding	protein-coding
	Description	myocardin-related transcription factor AMKL/myocardin-like protein 1basic, SAP and coiled-coil domainmegakaryoblastic leukemia (translocation) 1megakaryoblastic leukemia 1 proteinmegakaryocytic acute leukemia protein	keratin, type II cytoskeletal 4cytokeratin 4keratin 4, type IItype-II keratin Kb4
	Modification date	20200313	20200327
	UniProtAcc	.	P19013
	Ensembl transtripts involved in fusion gene	ENST00000309988, ENST00000349807, ENST00000353004, ENST00000354078, ENST00000489399,	ENST00000293774, ENST00000458244, ENST00000551956,
Fusion gene scores	* DoF score	4 X 4 X 2=32	10 X 16 X 5=800
	# samples	4	15
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(15/800*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAL [Title/Abstract] AND KRT4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAL(95719136)-KRT4(53205700), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAL	GO:0010735	positive regulation of transcription via serum response element binding	24440334
Hgene	MAL	GO:0044319	wound healing, spreading of cells	29391067
Hgene	MAL	GO:0045944	positive regulation of transcription by RNA polymerase II	14970199

Fusion gene breakpoints across MAL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KRT4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-7177-11A	MAL	chr2	95719136	-	KRT4	chr12	53205700	-

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Fusion Gene ORF analysis for MAL-KRT4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000309988	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000309988	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000309988	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000349807	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000349807	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000349807	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000353004	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000353004	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000353004	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000354078	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000354078	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
In-frame	ENST00000354078	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
intron-3CDS	ENST00000489399	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
intron-3CDS	ENST00000489399	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-
intron-3CDS	ENST00000489399	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309988	MAL	chr2	95719136	-	ENST00000458244	KRT4	chr12	53205700	-	2657	1097	2573	2022	183
ENST00000309988	MAL	chr2	95719136	-	ENST00000293774	KRT4	chr12	53205700	-	2657	1097	2573	2022	183
ENST00000309988	MAL	chr2	95719136	-	ENST00000551956	KRT4	chr12	53205700	-	2657	1097	2573	2022	183
ENST00000349807	MAL	chr2	95719136	-	ENST00000458244	KRT4	chr12	53205700	-	2254	694	2170	1619	183
ENST00000349807	MAL	chr2	95719136	-	ENST00000293774	KRT4	chr12	53205700	-	2254	694	2170	1619	183
ENST00000349807	MAL	chr2	95719136	-	ENST00000551956	KRT4	chr12	53205700	-	2254	694	2170	1619	183
ENST00000354078	MAL	chr2	95719136	-	ENST00000458244	KRT4	chr12	53205700	-	2380	820	2296	1745	183
ENST00000354078	MAL	chr2	95719136	-	ENST00000293774	KRT4	chr12	53205700	-	2380	820	2296	1745	183
ENST00000354078	MAL	chr2	95719136	-	ENST00000551956	KRT4	chr12	53205700	-	2380	820	2296	1745	183
ENST00000353004	MAL	chr2	95719136	-	ENST00000458244	KRT4	chr12	53205700	-	2422	862	2338	1787	183
ENST00000353004	MAL	chr2	95719136	-	ENST00000293774	KRT4	chr12	53205700	-	2422	862	2338	1787	183
ENST00000353004	MAL	chr2	95719136	-	ENST00000551956	KRT4	chr12	53205700	-	2422	862	2338	1787	183

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309988	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.023654254	0.9763457
ENST00000309988	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.023654254	0.9763457
ENST00000309988	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.023654254	0.9763457
ENST00000349807	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.4635504	0.5364496
ENST00000349807	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.4635504	0.5364496
ENST00000349807	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.4635504	0.5364496
ENST00000354078	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.36603847	0.6339615
ENST00000354078	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.36603847	0.6339615
ENST00000354078	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.36603847	0.6339615
ENST00000353004	ENST00000458244	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.42304388	0.57695615
ENST00000353004	ENST00000293774	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.42304388	0.57695615
ENST00000353004	ENST00000551956	MAL	chr2	95719136	-	KRT4	chr12	53205700	-	0.42304388	0.57695615

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Fusion Genomic Features for MAL-KRT4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAL-KRT4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:95719136/chr12:53205700)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KRT4 P19013
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

10_108

595.0

Compositional bias

Note=Gly-rich

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

456_512

595.0

Compositional bias

Note=Ser-rich

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

10_108

521.0

Compositional bias

Note=Gly-rich

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

456_512

521.0

Compositional bias

Note=Ser-rich

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

137_450

595.0

Domain

IF rod

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

137_450

521.0

Domain

IF rod

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

137_172

595.0

Region

Note=Coil 1A

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

173_191

595.0

Region

Note=Linker 1

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

192_284

595.0

Region

Note=Coil 1B

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

1_136

595.0

Region

Note=Head

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

285_307

595.0

Region

Note=Linker 12

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

308_447

595.0

Region

Note=Coil 2

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000293774

448_520

595.0

Region

Note=Tail

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

137_172

521.0

Region

Note=Coil 1A

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

173_191

521.0

Region

Note=Linker 1

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

192_284

521.0

Region

Note=Coil 1B

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

1_136

521.0

Region

Note=Head

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

285_307

521.0

Region

Note=Linker 12

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

308_447

521.0

Region

Note=Coil 2

Tgene

KRT4

chr2:95719136

chr12:53205700

ENST00000551956

448_520

521.0

Region

Note=Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

18_151

154.0

Domain

MARVEL

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

18_151

56.0

Domain

MARVEL

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

18_151

112.0

Domain

MARVEL

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

18_151

98.0

Domain

MARVEL

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

115_125

154.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

148_153

154.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

1_24

154.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

47_53

154.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

76_92

154.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

115_125

56.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

148_153

56.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

1_24

56.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

47_53

56.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

76_92

56.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

115_125

112.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

148_153

112.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

1_24

112.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

47_53

112.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

76_92

112.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

115_125

98.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

148_153

98.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

1_24

98.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

47_53

98.0

Topological domain

Extracellular

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

76_92

98.0

Topological domain

Cytoplasmic

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

126_147

154.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

25_46

154.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

54_75

154.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000309988

93_114

154.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

126_147

56.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

25_46

56.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

54_75

56.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000349807

93_114

56.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

126_147

112.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

25_46

112.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

54_75

112.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000353004

93_114

112.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

126_147

98.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

25_46

98.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

54_75

98.0

Transmembrane

Helical

Hgene

MAL

chr2:95719136

chr12:53205700

ENST00000354078

93_114

98.0

Transmembrane

Helical

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Fusion Gene Sequence for MAL-KRT4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>50959_50959_1_MAL-KRT4_MAL_chr2_95719136_ENST00000309988_KRT4_chr12_53205700_ENST00000293774_length(transcript)=2657nt_BP=1097nt
CCCGCGCGCGGGGGCGCCCAGGCCACTGGGCTCCGCGGAGCCAGCGAGAGGTCTGCGCGGAGTCTGAGCGGCGCTCGTCCCGTCCCAAGG
CCGACGCCAGCACGCCGTCATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGA
CTTGCTCTTCATCTTTGAGTTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGTGCCCTGGCCCCTGGTCCAGGGCTG
GGTGATGTTCGTGTCTGTGTTCTGCTTCGTGGCCACCACCACCTTGATCATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTG
GGTCACCTTGGACGCAGCCTACCACTGCACCGCTGCCCTCTTTTACCTCAGCGCCTCAGTCCTGGAGGCCCTGGCCACCATCACGATGCA
AGACGGCTTCACCTACAGGCACTACCATGAAAACATTGCTGCCGTGCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAA
TCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTT
TTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTG
GGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTC
ACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCC
CTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGAT
GTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAA
AATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAG
TAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCAC
CCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACT
TCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTG
CTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGA
CCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATG
CCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGG
ATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAA
ATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCT
TAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGA
GCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAG
ATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAG
ATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAAC
CTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAG
ACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTC
CTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCC
AGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAG

>50959_50959_1_MAL-KRT4_MAL_chr2_95719136_ENST00000309988_KRT4_chr12_53205700_ENST00000293774_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_2_MAL-KRT4_MAL_chr2_95719136_ENST00000309988_KRT4_chr12_53205700_ENST00000458244_length(transcript)=2657nt_BP=1097nt
CCCGCGCGCGGGGGCGCCCAGGCCACTGGGCTCCGCGGAGCCAGCGAGAGGTCTGCGCGGAGTCTGAGCGGCGCTCGTCCCGTCCCAAGG
CCGACGCCAGCACGCCGTCATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGA
CTTGCTCTTCATCTTTGAGTTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGTGCCCTGGCCCCTGGTCCAGGGCTG
GGTGATGTTCGTGTCTGTGTTCTGCTTCGTGGCCACCACCACCTTGATCATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTG
GGTCACCTTGGACGCAGCCTACCACTGCACCGCTGCCCTCTTTTACCTCAGCGCCTCAGTCCTGGAGGCCCTGGCCACCATCACGATGCA
AGACGGCTTCACCTACAGGCACTACCATGAAAACATTGCTGCCGTGCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAA
TCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTT
TTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTG
GGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTC
ACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCC
CTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGAT
GTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAA
AATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAG
TAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCAC
CCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACT
TCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTG
CTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGA
CCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATG
CCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGG
ATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAA
ATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCT
TAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGA
GCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAG
ATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAG
ATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAAC
CTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAG
ACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTC
CTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCC
AGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAG

>50959_50959_2_MAL-KRT4_MAL_chr2_95719136_ENST00000309988_KRT4_chr12_53205700_ENST00000458244_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_3_MAL-KRT4_MAL_chr2_95719136_ENST00000309988_KRT4_chr12_53205700_ENST00000551956_length(transcript)=2657nt_BP=1097nt
CCCGCGCGCGGGGGCGCCCAGGCCACTGGGCTCCGCGGAGCCAGCGAGAGGTCTGCGCGGAGTCTGAGCGGCGCTCGTCCCGTCCCAAGG
CCGACGCCAGCACGCCGTCATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGA
CTTGCTCTTCATCTTTGAGTTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGTGCCCTGGCCCCTGGTCCAGGGCTG
GGTGATGTTCGTGTCTGTGTTCTGCTTCGTGGCCACCACCACCTTGATCATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTG
GGTCACCTTGGACGCAGCCTACCACTGCACCGCTGCCCTCTTTTACCTCAGCGCCTCAGTCCTGGAGGCCCTGGCCACCATCACGATGCA
AGACGGCTTCACCTACAGGCACTACCATGAAAACATTGCTGCCGTGCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAA
TCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTT
TTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTG
GGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTC
ACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCC
CTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGAT
GTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAA
AATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAG
TAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCAC
CCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACT
TCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTG
CTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGA
CCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATG
CCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGG
ATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAA
ATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCT
TAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGA
GCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAG
ATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAG
ATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAAC
CTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAG
ACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTC
CTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCC
AGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAG

>50959_50959_3_MAL-KRT4_MAL_chr2_95719136_ENST00000309988_KRT4_chr12_53205700_ENST00000551956_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_4_MAL-KRT4_MAL_chr2_95719136_ENST00000349807_KRT4_chr12_53205700_ENST00000293774_length(transcript)=2254nt_BP=694nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGA
AAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAA
CCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGG
GAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGA
AGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAG
CTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTT
CCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACT
GGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGT
GGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCA
CTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCC
CCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCT
TGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGT
CATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACC
AAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTC
TTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACT
CTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTG
CAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACC
TACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGA
GTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCC
ATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACG
AGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGG
AGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCA
GCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCC
TGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAGTCTGAGCTGAAGACCATGCAGGACAGCGTGGAGGACTTCAAGA

>50959_50959_4_MAL-KRT4_MAL_chr2_95719136_ENST00000349807_KRT4_chr12_53205700_ENST00000293774_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_5_MAL-KRT4_MAL_chr2_95719136_ENST00000349807_KRT4_chr12_53205700_ENST00000458244_length(transcript)=2254nt_BP=694nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGA
AAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAA
CCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGG
GAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGA
AGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAG
CTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTT
CCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACT
GGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGT
GGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCA
CTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCC
CCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCT
TGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGT
CATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACC
AAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTC
TTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACT
CTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTG
CAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACC
TACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGA
GTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCC
ATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACG
AGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGG
AGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCA
GCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCC
TGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAGTCTGAGCTGAAGACCATGCAGGACAGCGTGGAGGACTTCAAGA

>50959_50959_5_MAL-KRT4_MAL_chr2_95719136_ENST00000349807_KRT4_chr12_53205700_ENST00000458244_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_6_MAL-KRT4_MAL_chr2_95719136_ENST00000349807_KRT4_chr12_53205700_ENST00000551956_length(transcript)=2254nt_BP=694nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGA
AAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAA
CCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGG
GAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGA
AGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAG
CTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTT
CCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACT
GGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGT
GGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCA
CTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCC
CCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCT
TGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGT
CATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACC
AAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTC
TTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACT
CTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTG
CAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACC
TACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGA
GTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCC
ATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACG
AGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGG
AGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCA
GCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCC
TGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAGTCTGAGCTGAAGACCATGCAGGACAGCGTGGAGGACTTCAAGA

>50959_50959_6_MAL-KRT4_MAL_chr2_95719136_ENST00000349807_KRT4_chr12_53205700_ENST00000551956_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_7_MAL-KRT4_MAL_chr2_95719136_ENST00000353004_KRT4_chr12_53205700_ENST00000293774_length(transcript)=2422nt_BP=862nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGTGCCCTGGCCCCTGGTCCAGGGCTGGGTGATGTTCGTGTCTGTG
TTCTGCTTCGTGGCCACCACCACCTTGATCATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTGGGTCACCTTGCATAGCCAC
TCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGG
TGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCAC
TGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTG
TCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGT
GACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCG
CCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCAT
GGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGC
GGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCT
GGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCT
GGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCC
CATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCT
GGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAAT
TATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTC
CAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGC
AGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCC
GTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAG
GAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTG
CTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAG
AGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACA
CGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCC
AGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGG
ACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGAC
TTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGC

>50959_50959_7_MAL-KRT4_MAL_chr2_95719136_ENST00000353004_KRT4_chr12_53205700_ENST00000293774_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_8_MAL-KRT4_MAL_chr2_95719136_ENST00000353004_KRT4_chr12_53205700_ENST00000458244_length(transcript)=2422nt_BP=862nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGTGCCCTGGCCCCTGGTCCAGGGCTGGGTGATGTTCGTGTCTGTG
TTCTGCTTCGTGGCCACCACCACCTTGATCATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTGGGTCACCTTGCATAGCCAC
TCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGG
TGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCAC
TGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTG
TCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGT
GACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCG
CCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCAT
GGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGC
GGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCT
GGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCT
GGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCC
CATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCT
GGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAAT
TATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTC
CAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGC
AGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCC
GTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAG
GAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTG
CTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAG
AGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACA
CGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCC
AGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGG
ACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGAC
TTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGC

>50959_50959_8_MAL-KRT4_MAL_chr2_95719136_ENST00000353004_KRT4_chr12_53205700_ENST00000458244_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_9_MAL-KRT4_MAL_chr2_95719136_ENST00000353004_KRT4_chr12_53205700_ENST00000551956_length(transcript)=2422nt_BP=862nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGTGCCCTGGCCCCTGGTCCAGGGCTGGGTGATGTTCGTGTCTGTG
TTCTGCTTCGTGGCCACCACCACCTTGATCATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTGGGTCACCTTGCATAGCCAC
TCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATGGAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGG
TGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAAACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCAC
TGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTG
TCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCTGTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGT
GACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGCAGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCG
CCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGCATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCAT
GGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCTTAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGC
GGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGCTTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCT
GGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAACAAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCT
GGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTCCATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCC
CATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGACAGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCT
GGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCACCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAAT
TATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTCCCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTC
CAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAACCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGC
AGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTGGAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCC
GTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGATGCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAG
GAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATGAGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTG
CTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGGTTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAG
AGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGAACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACA
CGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACCTGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCC
AGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGGACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGG
ACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATGATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGAC
TTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAAACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGC

>50959_50959_9_MAL-KRT4_MAL_chr2_95719136_ENST00000353004_KRT4_chr12_53205700_ENST00000551956_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_10_MAL-KRT4_MAL_chr2_95719136_ENST00000354078_KRT4_chr12_53205700_ENST00000293774_length(transcript)=2380nt_BP=820nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTGACGCAGCCTACCACTGCACCGCTGCCCTCTTTTACCTCAGCGCCTCAGTCCTGGAGGCCCTGGCCACCATCACGATGCAAGACGGC
TTCACCTACAGGCACTACCATGAAAACATTGCTGCCGTGCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATG
GAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAA
ACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTG
TGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCT
GTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGC
AGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGC
ATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCT
TAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGC
TTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAAC
AAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTC
CATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGAC
AGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCA
CCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTC
CCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAA
CCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTG
GAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGAT
GCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATG
AGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGG
TTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGA
ACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACC
TGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGG
ACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATG
ATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAA
ACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAGTCTGAGC

>50959_50959_10_MAL-KRT4_MAL_chr2_95719136_ENST00000354078_KRT4_chr12_53205700_ENST00000293774_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_11_MAL-KRT4_MAL_chr2_95719136_ENST00000354078_KRT4_chr12_53205700_ENST00000458244_length(transcript)=2380nt_BP=820nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTGACGCAGCCTACCACTGCACCGCTGCCCTCTTTTACCTCAGCGCCTCAGTCCTGGAGGCCCTGGCCACCATCACGATGCAAGACGGC
TTCACCTACAGGCACTACCATGAAAACATTGCTGCCGTGCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATG
GAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAA
ACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTG
TGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCT
GTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGC
AGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGC
ATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCT
TAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGC
TTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAAC
AAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTC
CATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGAC
AGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCA
CCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTC
CCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAA
CCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTG
GAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGAT
GCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATG
AGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGG
TTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGA
ACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACC
TGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGG
ACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATG
ATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAA
ACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAGTCTGAGC

>50959_50959_11_MAL-KRT4_MAL_chr2_95719136_ENST00000354078_KRT4_chr12_53205700_ENST00000458244_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------
>50959_50959_12_MAL-KRT4_MAL_chr2_95719136_ENST00000354078_KRT4_chr12_53205700_ENST00000551956_length(transcript)=2380nt_BP=820nt
ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCTCTTCATCTTTGAG
TTTGACGCAGCCTACCACTGCACCGCTGCCCTCTTTTACCTCAGCGCCTCAGTCCTGGAGGCCCTGGCCACCATCACGATGCAAGACGGC
TTCACCTACAGGCACTACCATGAAAACATTGCTGCCGTGCATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATG
GAAGTCTTCATAAAGCCGCAGTAGAACTTGAGCTGAAAACCCAGATGGTGTTAACTGGCCGCCCCACTTTCCGGCATAACTTTTTAGAAA
ACAGAAATGCCCTTGATGGTGGAAAAAAGAAAACAACCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGCTCGTGGGTGCTG
TGTTTACTCTCCCGTGTGCCTTCGCGTCCGGGTTGGGAGCTTGCTGTGTCTAACCTCCAACTGCTGTGCTGTCTGCTAGGGTCACCTCCT
GTTTGTGAAAGGGGACCTTCTTGTTCGGGGGTGGGAAGTGGCGACCGTGACCTGAGAAGGAAAGAAAGATCCTCTGCTGACCCCTGGAGC
AGCTCTCGAGAACTACCTGTTGGTATTGTCCACAAGCTCTCCCGAGCGCCCCATCTTGTGCCATGTTTTAAGTCTTCATGGATGTTCTGC
ATGTCATGGGGACTAAAACTCACCCAACAGATCTTTCCAGAGGTCCATGGTGGAAGACGATAACCCTGTGAAATACTTTATAAAATGTCT
TAATGTTCAACTGTGGTCAGCGGTAGCACCAGCACTGGAGGCATCAGCGGAGGATTAGGAAGTGGCTCCGGGTTTGGCCTGAGTAGTGGC
TTTGGCTCCGGCTCTGGAAGTGGCTTTGGGTTTGGTGGCAGTGTCTCTGGCAGTTCCAGCAGCAAGATCATCTCTACCACCACCCTGAAC
AAGAGACGATAGAGGAGACGAGGTCCCTGCAGCTCACTGTGTCCAGCTGGGCCCAGCACTGGTGTCTCTGTGCTTCCTTCACTTCACCTC
CATCCTCTGTCTCTGGGGCTCATCTTACTAGTATCCCCTCCACTATCCCATGGGCTCTCTCTGCCCCAGGATGATCTTCTGTGCTGGGAC
AGGGACTCTGCCTCTTGGAGTTTGGTAGCTACTTCTTGATTTGGGCCTGGTGACCCACCTGGAATGGGAAGGATGTCAGCTGACCTCTCA
CCTCCCATGGACAGAGAAGAAAATGACCAGGAGTGTCATCTCCAGAATTATTGGGGTCACATATGTCCCTTCCCAGTCCAATGCCATCTC
CCACTAGATCCTGTATTATCCATCTACATCAGAACCAAACTACTTCTCCAACACCCGGCAGCACTTGGCCCTGCAAGCTTAGGATGAGAA
CCACTTAGTGTCCCATTCTACTCCTCTCATTCCCTCTTATCCATCTGCAGGTGAATCTTCAATAAAATGCTTTTGTCATTCAAATGTCTG
GAGAATGCCAGAGTGCCGTGAGCATCTTGCCAGACTCTTCAGGTATCCGTGGCTGATGCAGAGCAGCGAGGTGAGAATGCCCTTAAAGAT
GCCCACAGCAAGCGCGTAGAGCTGGAGGCTGCCCTGCAGCAGGCCAAGGAGGAGCTGGCACGAATGCTGCGTGAGTACCAGGAGCTCATG
AGTGTGAAGCTGGCCTTGGACATCGAGATCGCCACCTACCGCAAACTGCTGGAGGGCGAGGAGTACAGGTCCAGCAGCTCCAGATCTCGG
TTGACCAACATGGTGACAACCTGAAGAACACCAAGAGTGAAATTGCAGAGCTCAACAGGATGATCCAGAGGCTGCGGGCAGAGATCGAGA
ACATCAAGAAGCAGGAGCTGTCCCAGATGCAGACCCATGTCAGCGACACGTCCGTGGTCCTTTCCATGGACAACAACCGCAACCTGGACC
TGGACAGCATTATTGCCGAGGTCCGTGCCCAGTACGAGGAGATTGCCCAGAGGAGCAAGGCTGAGGCTGAAGCCCTGTACCAGACCAAGG
ACGTGGATGCTGCCTACCTGAACAAGGTGGAGTTGGAGGCCAAGGTGGACAGTCTTAATGACGAGATCAACTTCCTGAAGGTCCTCTATG
ATGCGGTATGAAGAGGAGATCAACAAACGCACAGCAGCCGAGAATGACTTTGTGGTCCTAAAGAAGAGACGACCACCACCTCCAGCAAAA
ACCTTGAGCCCCTCTTTGAGACCTACCTCAGTGTCCTGAGGAAGCAGCTAGATACCTTGGGCAATGACAAAGGGCGCCTGCAGTCTGAGC

>50959_50959_12_MAL-KRT4_MAL_chr2_95719136_ENST00000354078_KRT4_chr12_53205700_ENST00000551956_length(amino acids)=183AA_BP=1
MLPQDTEVGLKEGLKVFAGGGGRLFFRTTKSFSAAVRLLISSSYRIIEDLQEVDLVIKTVHLGLQLHLVQVGSIHVLGLVQGFSLSLAPL
GNLLVLGTDLGNNAVQVQVAVVVHGKDHGRVADMGLHLGQLLLLDVLDLCPQPLDHPVELCNFTLGVLQVVTMLVNRDLELLDLYSSPSS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MAL-KRT4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MAL-KRT4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MAL-KRT4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source