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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MALT1-RTKN2 (FusionGDB2 ID:50983)

Fusion Gene Summary for MALT1-RTKN2

check button Fusion gene summary
Fusion gene informationFusion gene name: MALT1-RTKN2
Fusion gene ID: 50983
HgeneTgene
Gene symbol

MALT1

RTKN2

Gene ID

10892

219790

Gene nameMALT1 paracaspaserhotekin 2
SynonymsIMD12|MLT|MLT1|PCASP1PLEKHK1|bA531F24.1
Cytomap

18q21.32

10q21.2

Type of geneprotein-codingprotein-coding
Descriptionmucosa-associated lymphoid tissue lymphoma translocation protein 1MALT1 proteasecaspase-like proteinmucosa associated lymphoid tissue lymphoma translocation gene 1paracaspase-1rhotekin-2PH domain-containing family K member 1pleckstrin homology domain-containing family K member 1
Modification date2020031520200313
UniProtAcc

Q9UDY8

.
Ensembl transtripts involved in fusion geneENST00000345724, ENST00000348428, 
ENST00000395260, ENST00000315289, 
ENST00000373789, ENST00000395265, 
Fusion gene scores* DoF score5 X 4 X 5=10012 X 9 X 8=864
# samples 511
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/864*10)=-2.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MALT1 [Title/Abstract] AND RTKN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMALT1(56367823)-RTKN2(63959620), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMALT1

GO:0006508

proteolysis

18223652

HgeneMALT1

GO:0042981

regulation of apoptotic process

12819136

HgeneMALT1

GO:0050852

T cell receptor signaling pathway

15125833

HgeneMALT1

GO:0051168

nuclear export

16123224


check buttonFusion gene breakpoints across MALT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RTKN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A6Y2MALT1chr18

56367823

+RTKN2chr10

63959620

-


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Fusion Gene ORF analysis for MALT1-RTKN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000345724ENST00000395260MALT1chr18

56367823

+RTKN2chr10

63959620

-
5CDS-intronENST00000348428ENST00000395260MALT1chr18

56367823

+RTKN2chr10

63959620

-
In-frameENST00000345724ENST00000315289MALT1chr18

56367823

+RTKN2chr10

63959620

-
In-frameENST00000345724ENST00000373789MALT1chr18

56367823

+RTKN2chr10

63959620

-
In-frameENST00000345724ENST00000395265MALT1chr18

56367823

+RTKN2chr10

63959620

-
In-frameENST00000348428ENST00000315289MALT1chr18

56367823

+RTKN2chr10

63959620

-
In-frameENST00000348428ENST00000373789MALT1chr18

56367823

+RTKN2chr10

63959620

-
In-frameENST00000348428ENST00000395265MALT1chr18

56367823

+RTKN2chr10

63959620

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000348428MALT1chr1856367823+ENST00000315289RTKN2chr1063959620-25299071351241368
ENST00000348428MALT1chr1856367823+ENST00000395265RTKN2chr1063959620-12429071351241368
ENST00000348428MALT1chr1856367823+ENST00000373789RTKN2chr1063959620-62659071351550471
ENST00000345724MALT1chr1856367823+ENST00000315289RTKN2chr1063959620-23837611121095327
ENST00000345724MALT1chr1856367823+ENST00000395265RTKN2chr1063959620-10967611121095328
ENST00000345724MALT1chr1856367823+ENST00000373789RTKN2chr1063959620-61197611121404430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000348428ENST00000315289MALT1chr1856367823+RTKN2chr1063959620-0.0018363810.99816364
ENST00000348428ENST00000395265MALT1chr1856367823+RTKN2chr1063959620-0.0109977780.9890022
ENST00000348428ENST00000373789MALT1chr1856367823+RTKN2chr1063959620-0.0003981410.9996019
ENST00000345724ENST00000315289MALT1chr1856367823+RTKN2chr1063959620-0.0012528280.9987471
ENST00000345724ENST00000395265MALT1chr1856367823+RTKN2chr1063959620-0.0062584270.9937416
ENST00000345724ENST00000373789MALT1chr1856367823+RTKN2chr1063959620-0.0003705560.9996294

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Fusion Genomic Features for MALT1-RTKN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MALT1-RTKN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:56367823/chr10:63959620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MALT1

Q9UDY8

.
FUNCTION: Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475). {ECO:0000250|UniProtKB:Q2TBA3, ECO:0000269|PubMed:11262391, ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:24074955, ECO:0000269|PubMed:31133753}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMALT1chr18:56367823chr10:63959620ENST00000345724+416125_201216814.0DomainNote=Ig-like C2-type 1
HgeneMALT1chr18:56367823chr10:63959620ENST00000345724+41639_126216814.0DomainNote=Death
HgeneMALT1chr18:56367823chr10:63959620ENST00000348428+417125_201216825.0DomainNote=Ig-like C2-type 1
HgeneMALT1chr18:56367823chr10:63959620ENST00000348428+41739_126216825.0DomainNote=Death
TgeneRTKN2chr18:56367823chr10:63959620ENST000003952600556_910164.0Coiled coilOntology_term=ECO:0000255
TgeneRTKN2chr18:56367823chr10:63959620ENST0000039526005286_3930164.0DomainPH
TgeneRTKN2chr18:56367823chr10:63959620ENST00000395260055_810164.0DomainREM-1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMALT1chr18:56367823chr10:63959620ENST00000345724+416212_305216814.0DomainNote=Ig-like C2-type 2
HgeneMALT1chr18:56367823chr10:63959620ENST00000348428+417212_305216825.0DomainNote=Ig-like C2-type 2
HgeneMALT1chr18:56367823chr10:63959620ENST00000345724+416369_376216814.0MotifNote=Nuclear export signal
HgeneMALT1chr18:56367823chr10:63959620ENST00000348428+417369_376216825.0MotifNote=Nuclear export signal
HgeneMALT1chr18:56367823chr10:63959620ENST00000345724+416348_562216814.0RegionNote=Caspase-like
HgeneMALT1chr18:56367823chr10:63959620ENST00000348428+417348_562216825.0RegionNote=Caspase-like
TgeneRTKN2chr18:56367823chr10:63959620ENST0000037378991256_91395610.0Coiled coilOntology_term=ECO:0000255
TgeneRTKN2chr18:56367823chr10:63959620ENST00000395265101456_91416528.0Coiled coilOntology_term=ECO:0000255
TgeneRTKN2chr18:56367823chr10:63959620ENST00000373789912286_393395610.0DomainPH
TgeneRTKN2chr18:56367823chr10:63959620ENST000003737899125_81395610.0DomainREM-1
TgeneRTKN2chr18:56367823chr10:63959620ENST000003952651014286_393416528.0DomainPH
TgeneRTKN2chr18:56367823chr10:63959620ENST0000039526510145_81416528.0DomainREM-1


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Fusion Gene Sequence for MALT1-RTKN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>50983_50983_1_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000345724_RTKN2_chr10_63959620_ENST00000315289_length(transcript)=2383nt_BP=761nt
GTTCTTCCGCCCCTGCCTCCGCGGCTCGGAGGCGAGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACGGGGCGGGCGGGAGCCCCGGCAG
TCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTGGGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGC
CCCTCCGGCCGGCGCGACCCTCAACCGCCTGCGGGAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCAGGCGCCCGAGGGCCGGGG
CTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGCGGGCGCCTCCGCCTCAGTTGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGA
GCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGAAGTTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTAT
GGAACACACTGAAGTTCTTCAGCTTCTCAGCCCCCCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTT
TGTGAAACTGTGTTGCCGGGCAACTGGACATCCTTTTGTTCAATATCAGTGGTTCAAAATGAATAAAGAGATTCCAAATGGAAATACATC
AGAGCTTATTTTTAATGCAGTGCATGTAAAAGATGCAGGCTTTTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTG
GTCACAGCTGGATGTTTGCGACATCCCAGAGAGCTTCCAGAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTC
ACCACGGAAACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTT
AACGGATATAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCAC
ACTCTTTGATGGTAACCATCAAATGGTCATCCAGAAAAAGAATAATAGTAATCAACTACATAATCTCCAGAAACTGCCAGCAACTTCCAA
ATTCCTCTTCACATAGCTTCTCAAATACTTCATTAGAACCAGTGTGAAAAATTTAAAATACAATGTGACATTTCTCTAGTAGAATGTAAG
CTTCATGAGGGAAAAGACAACGCGTCTCCTTCCTGTATTCCTAGCACCCAGTACGGCACCTGACACATAATAGTGACCTTAGAAGAATAT
TTAAGAGTCATTGAGTAAACATTTTGTAGAGCTGTCCATGTTTATTTTCCATTCAGTGTTTACCAGGTGTCTGCTATTTGGACAGTCACT
TCATTGTTCATTAGTACATGACTTTGGTAAATATATCTCCTGTGAAGAGAAATATTATAACTACTATGGCATTCAACACTGGTATTTCAG
TTACTCAACTAATCCACCCACTGATGGAGTGAACCTTGAATTAAATGCTTTGAAGAATAAAGTGAATCTTGATAAAAATCAAAGGCTGAA
GAAATCTTGTTTGACAGAAGGCATGAACAAAAATGCTAAAATTAATACTGTTTGTGGAGAAACACTCATTCCACCGCAGACTAAATGGAG
TTCATGAGTATCAAAATGCCTATGTGATCAAAAGGCAGAAACAGCTTCTTTTTACTAGGTCTGTTAATATTCCAGGACTCATAATATTGT
GCCTACATGAGCACCTGTGTTTGTGGTAACTCAAAGTATTTGAACACCTTATCTCATCCAACCTCAAATTTCCTGTGAGGTATTTAAGCA
CCGAGAGCTCTTGGTACTGTTTTCAAGATGAAGCAGATGAATTAGAGAGGCTGTTCACACACCAAATTTCACAGAAGCCTATGGAGGAAA
TGACGGGGAGACTTACCAGTTAACACCCAGTTGCAGAAATCAATGTCAGAGCTTGAAAGGACCTTATAAACCCCTGATCCAATGTGGACT
TTCCTAGTAAGACTTCTGTTTGCAGTGACTTGGTTCATTTCACCAACCACAAGAATTTTAAGTAATTTTTAATCATAAAAGTAACATAGA
ACATAGTAATACATATATACGTACATACATGATACAGAAAGGTATCAAAAAACAAAAACATATATTACTTCCTCCTCTAACATTCCAGTG
CCAGTTTCCAAAGATTCCTATTACCCAGAGGTAACCACTGTTAATAATTTTTAATGTATATTTCCAAAAATTTTTTATGCATTTAGAAAT
GTGTGCATGTGGGTGATGGGTGCACCAAAATCTCAGAAATCACCACTAAAGAACTTACTCATGTAACCAAACACCATGTGGTCCCCCAAA

>50983_50983_1_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000345724_RTKN2_chr10_63959620_ENST00000315289_length(amino acids)=327AA_BP=217
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSL
CLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKK

--------------------------------------------------------------
>50983_50983_2_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000345724_RTKN2_chr10_63959620_ENST00000373789_length(transcript)=6119nt_BP=761nt
GTTCTTCCGCCCCTGCCTCCGCGGCTCGGAGGCGAGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACGGGGCGGGCGGGAGCCCCGGCAG
TCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTGGGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGC
CCCTCCGGCCGGCGCGACCCTCAACCGCCTGCGGGAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCAGGCGCCCGAGGGCCGGGG
CTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGCGGGCGCCTCCGCCTCAGTTGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGA
GCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGAAGTTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTAT
GGAACACACTGAAGTTCTTCAGCTTCTCAGCCCCCCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTT
TGTGAAACTGTGTTGCCGGGCAACTGGACATCCTTTTGTTCAATATCAGTGGTTCAAAATGAATAAAGAGATTCCAAATGGAAATACATC
AGAGCTTATTTTTAATGCAGTGCATGTAAAAGATGCAGGCTTTTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTG
GTCACAGCTGGATGTTTGCGACATCCCAGAGAGCTTCCAGAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTC
ACCACGGAAACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTT
AACGGATATAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCAC
ACTCTTTGATGGTAACCATCAAATGGTCATCCAGAAAAAGGTACTGTATCCTGCAAGTGAGCCATTACATGATGAAAAAGGGAAAAAGAG
ACAAGCTCCCCTTCCTCCTTCTGATAAACTTCCATTCAGCTTAAAATCACAGAGTAACACAGATCAATTGGTTAAGGACAACTGGGGAAA
AACAAGTGTATCTCAGACATCGTCTTTGGATACCAAACTATCAACTCTAATGCATCACTTACAGAAACCAATGGCTGCTCCTCGAAAACT
TCTGCCTGCCAGGAGAAATAGATTAAGTGATGGTGAGCACACAGACACTAAAACCAATTTTGAAGCCAAGCCAGTGCCAGCTCCAAGGCA
GAAATCCATCAAAGACATTCTGGACCCTAGATCATGGCTGCAGGCACAAGTATAGAAAACTCTTAATGATAAAACATTTAACAAAATCTA
TAACTGTGAAGCTTAATTCAGAGGCATTATAGAATAATGTGTAATTATATAGGTAAATATAGTGATTTATACCAATAATTAATAAGCTAT
TAGGTATAGAAAAACATTTTATAATGAAGAAGTGGATTTCTCTTTTACTCCTGATTTGCAGAATGTAAGTGATTTCTCCAGCAGTGTGCA
AGAGGCAGTTTCTAGACAATATCCTAATTGTTGGAAGGGTTAATTTATTCCTGAATTAGTACCAGGCAGTGAATAAGCCCTAGGCAGAAT
AAAGCATTAAAATTTCTTTTGGGGAGAGACTGTCTAGTAATTTAAAATGTGTTAAATATGAACCATATTCTCATTGTGAGAATTTTAATA
CTAATGGAATGTTTCAAAGGTTTTATTCAAACCACAAATTATAGAATCCACCCAAGAAAATTTTCTTAGCATTCTGGAATTCTCATCTAA
TGGTTCACTGGCTCTCATCTATTGTTTAACTCACTAGTTTATAGGCCTGACCTTTTAAATTCCTGGGATAAATTTTAGAATATTAAATTC
TTCATCTTTAAAGGGAATTTGTAATGTGCTATTCAAACTTGTTTCCTTGATGAGCCCTGAAATACTGTTGACATTAACTTTCATAAATGA
AGCATAACACTTACTAGTTTAGAGAAATGGTAGATGAAATGCTCTTTACATTCAATTTTCTGTGTGTGGTGCTAATTTCCATTGTGACTT
TGGAATTTAGGGAAGTGAGTAGCTGATCAACACCTTAAAATTCATTTAATACTTATTTAAAAAGAAGATGAGAGATTCAAAAATATCAGA
AAAGTTGGCCATGGTAAATAATTTTCAGAATTCTTTTTTAAAATTTTAATTAGATTTCCTTTTCCTAGTAAGAGTTGATGTCTGCTAGTG
GTATTTTTCATTAAATGTCATATTCTTACAACAGTGACATTGGAATCATTTCCATAGGAGGTAATTTCCATAGCAACTAATCATAGTGAC
CCAAACAGGATTATAAAGTCAAGTGAGGAATAAATAGCAGAAAAATACCTTAAAGGAACAAAAAATCCATTTTTTATAATAATGCTTTTT
GTAAACAAGAGCAGAACAGTTTTAAAAATCTAATTAGAATTTCCAAATAAAACAGTTTCCATAAGGTGTCAGCAACAGCACTAAAAATCT
CAAATCACACTGAACCCTAAATGTCATTGCAAGAAATAAAAATTTAAGAATTAAATTGCTGCCCTGTGTATAATCTCTTGAGATCTTTTT
AAAGCTAGCAAGAACTCTATTTGGATCAGAACTACATTATTACAAAACAAAATGAACACTTGACCAAAAAACCACATTAATTTAAATGGA
GCCTTTCATTATTTTCAGATAGCGGGGTCTTTTCCATTTATAGAGAATGATGTAACTGCCAGGACACTTTTGTGTTTGCCCAGGACTCCT
AGTAAGAATTGAATCTTGAGGGAGTAATGATAACAAAAGGTTTCTTGTGACTGGTAACATCAGGACAGACAGAGTTTTTGGTGAGAAGAA
AGTACTATATGCCTGCTTGATAGCATGTAGAGATCATCACATGTATGGAAACCTTAAAAAGTAAACTTATTTTTTCTAACTAGAAGGCTC
TCATAAGTTTCTGTTATGATTGCCATTTCAATAAATGACATTAAAAATCTAAAGGATATTATTGTTTGAATTTTTGGGTTATTTTTTAAA
ACTTCATTGCTGTTTTTGACAGCATTTGTGACTGTCATTGCCACTAAATTATTGAGCTAGAAGATGCTGCAGGGAAAATTGTTTTGAAGC
TGGCATCTAAGCATTCTTTTTTTTTTCCTAGTTGATGCCTTCCTTTATTACAAATCAGTATTAAAACTTCCAGATTATATTCTTGTCATT
TTTCCTCATGCAGATAACAGCAGGAAGGACTTAAGGTGTATAAGAAAAAGAAAGTATTCATACAGAAATTACCTAGCAGTTGTGCCCTCA
GAGTAGAACTTTGAAACAGGACTGAAGCCCTTTTTACCTAGAACCATTTAAAAGCCTGAGCAAGGACCACCACCCCCTCCCCACCAAATT
ATTCGGTCTCTTTCTGGGGGGCCCAGCTTACTGTATGTTACAAGTCTTTGAAATGGGTCTGGTGTCTTCAGCTCCTGAAATGCTAATTTA
CCCCTTACCTAAGGAGTGTAGTTATAATACAGAGTTGGTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTC
CTTCCTTCCTTCCTTCATTCCCTCTGTCCGTCTCTCCTTCCCTCCTTCCCTCCTTCCTTCCTTTTTGTCTTTGTTTCTTTCTCTGGCCCC
CTGTCCTCTCTCTCTGTCTCATCCCCTTTTCCCACTTTCCTTCTGTCTCTCCTTCCTCCCTTCCTTTACAGTTTAAAAAAAAAATCTAAA
AATAGTTAAGCACTGTGTCAAAGAGTGTTTCAAAAGAATTGTTTGTTTTCTCATTTCTTAAACCAGAAGTTTATGACAAATAAATATGCC
ATGTAATATGAAAGCTGCTTCAGCTTTTTATGAGCTTTCACATTCCTTGTTTGTCCTTTTAATTTGTTTCTTGATATATGAAGACTATAA
ACTTGAAACAAAGAGTTAGCTGTCAGCTCTTGATAATATAATTGGGGAAACAGAATAGATATTTTATGATATGATAATTCTGATGATCTA
AAGATAATGTCTTAGACAATTACCTTTACATTTCAAGCTCTGGGATATAAATTACGTAGTCAGCATTAAGATAGTATTATTTTTAATTGC
TACTAAGTGGTAACTTTTGTATTTTAATATCTTGCAAGGGCAAAGAAGGCATTTTTAAAATTCTAAATGCACACCTCCTAAGGTAAATAG
TCTTTCAAAAATATCAGGCGTGCCAACTCTTGCTGAGTTTTGTTAAATCCTCCTTAACTGTCTGCAGTGCCCCCTGACTTCTTTTAAATG
GATGTGAATATATGTGGAAAACTAAATCCATTTATTATAAATGCCTTATCTTTACCCTTTGGGATCTTACTAAATGCATTTTACCTGCTA
CTATTTATTAAAAATGGAAGCTGTCTTGAATTAGAGATACCTCACGTAAGGTAGGTTAAGCAGTCAAGTATTTCTTTAGGCTTATGTTCA
GCACCTCAGCCCCCTACTGAGAAGTTAATTAATTCAGTCCAAAATGAAATTATAGGGCAGTTTGGTGCAATTTATGTTAAATGCCATTTG
AATGTAATCACCTGTGTTACCACGAATGAGGCACAACTATACTACATGGACAGAGTACTGCATTGCACCATGAGCAAGAACTGCTCTGCA
AGAAAAATATCTGTCCCTGTGGTCTGAATTTATCAAAACTCATTTTCTTGTTAAAGAGTGAATTATTGAATAGTAATTAAACTTTAACTG
ATGACCATTTATATTCTAGTAGCCATCTTCACTGTTAGTCTTAAATTATAATGTAAAGTTGACATTTTCCCCTTACATTTCAAAGGCATC
ACTATTTTTAAATGTTTACATATGTTTACATGTTTGTGTGCAACTGCTTCATTGCTATTAATAGTTAAATGAAATCTGCATATTCTGGAT
CATAGATGTTCTTAGTTAACTCTGGGAAAGATGTTACCTTTGGGTTTTTAAAAGACAAGTCATCATTTGAAAATATATTAGGGTGTGTTG
ATTTTCTGACATGCTTGTGTAATTGGCTTTGTTTATAATTTTTATTTTTTAATATGGGTCAGACTTTTGGATTAAAAAGTATTATATCAT
GGACATACATTTTTTAAAGTACCAAAGGTATTTGGTAAGCGAGCCCAAGTCATGTAATTGAAACTTCTGTACATTAAAAGAACTGATTCA
TGAAGACGTTTTCTAACTTTTTCTCTTTAAGTGCTCCTCTAGACTAGACTGATTGAAGTAGACAGTGTGGTGGAATCAGTTTAATCAGAA
AAAGACATACCAAGTAGCTGGTGCTAATTATTATAAGACTAACATTCTGATAAGCCATGGTATAATTAACATTATTAAAATGTTTACATA
TAATCCTTCTTAAAGTATACTCTTTTAAAAATCCATTGACATAACCTTACTTTTAGTTTAGTGATCCAGAATTTCCCCAGAGCTTAAGCC
ACTGCAGTAAATTAGGTACGTAGGATATTCAGTCGCTACTAGCCACAAGGAGTCTCCTTATTTTAATGTACCTCCCTCAGTACTTTATTC
CTGCAGAGCGCCTCAGAGTGGGGGAGAGAAATGAGCAATCCTGGCTCAGTTGGATTATTTCAGCATTTTATTTCTAAATCTGTAGTGTGA
TCAGAAATATTTAAAATTAAAAAAATACTTTACAGAGAGAGGCCTACTAATCAATGTGCTTAGAGAAACAAACTACCTTTACATTCAATT
AACAACAAAAAAAGTTACAGAAATTTTAACAAACATTTTTCTTTATCTGAGTATGGGAGAAAATACTAATGCTGACACGTTTAATAATTA
GAAAAGATCATTCCAGATCTTATGGAAAATTGTGTTTTAAATTCCAGCAGTTTGCTCTTGAGACATGGTAATCTCTTAATGTAACTACTA

>50983_50983_2_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000345724_RTKN2_chr10_63959620_ENST00000373789_length(amino acids)=430AA_BP=217
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSL
CLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKK
IEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTS

--------------------------------------------------------------
>50983_50983_3_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000345724_RTKN2_chr10_63959620_ENST00000395265_length(transcript)=1096nt_BP=761nt
GTTCTTCCGCCCCTGCCTCCGCGGCTCGGAGGCGAGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACGGGGCGGGCGGGAGCCCCGGCAG
TCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTGGGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGC
CCCTCCGGCCGGCGCGACCCTCAACCGCCTGCGGGAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCAGGCGCCCGAGGGCCGGGG
CTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGCGGGCGCCTCCGCCTCAGTTGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGA
GCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGAAGTTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTAT
GGAACACACTGAAGTTCTTCAGCTTCTCAGCCCCCCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTT
TGTGAAACTGTGTTGCCGGGCAACTGGACATCCTTTTGTTCAATATCAGTGGTTCAAAATGAATAAAGAGATTCCAAATGGAAATACATC
AGAGCTTATTTTTAATGCAGTGCATGTAAAAGATGCAGGCTTTTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTG
GTCACAGCTGGATGTTTGCGACATCCCAGAGAGCTTCCAGAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTC
ACCACGGAAACCACCTTTGTTCTTGACAAAAGAGGCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTT
AACGGATATAATACAAAAAAAAATTGAAGAGACAAATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCAC
ACTCTTTGATGGTAACCATCAAATGGTCATCCAGAAAAAGAATAATAGTAATCAACTACATAATCTCCAGAAACTGCCAGCAACTTCCAA

>50983_50983_3_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000345724_RTKN2_chr10_63959620_ENST00000395265_length(amino acids)=328AA_BP=217
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSL
CLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKK

--------------------------------------------------------------
>50983_50983_4_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000348428_RTKN2_chr10_63959620_ENST00000315289_length(transcript)=2529nt_BP=907nt
CGAGGCTCCGTGCCCCGCCCCCCGGGTGCCCCGCCCCTTTGCGCGGCTGGCGCGGCCAGCAGGCCAGGCTCCCCTCGGCAAACCTGTCTA
ATTGGGGCGGGGAGCGGAGCTTCCTCCTCTGAGGGCCGTGCCGCGCTGCCAGATTTGTTCTTCCGCCCCTGCCTCCGCGGCTCGGAGGCG
AGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACGGGGCGGGCGGGAGCCCCGGCAGTCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTG
GGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGCCCCTCCGGCCGGCGCGACCCTCAACCGCCTGCGG
GAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCAGGCGCCCGAGGGCCGGGGCTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGC
GGGCGCCTCCGCCTCAGTTGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGAGCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGAAG
TTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTATGGAACACACTGAAGTTCTTCAGCTTCTCAGCCCC
CCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTTTGTGAAACTGTGTTGCCGGGCAACTGGACATCCT
TTTGTTCAATATCAGTGGTTCAAAATGAATAAAGAGATTCCAAATGGAAATACATCAGAGCTTATTTTTAATGCAGTGCATGTAAAAGAT
GCAGGCTTTTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTGGTCACAGCTGGATGTTTGCGACATCCCAGAGAGC
TTCCAGAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTTTGTTCTTGACAAAAGAG
GCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAAAAAAAATTGAAGAGACA
AATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACCATCAAATGGTCATCCAG
AAAAAGAATAATAGTAATCAACTACATAATCTCCAGAAACTGCCAGCAACTTCCAAATTCCTCTTCACATAGCTTCTCAAATACTTCATT
AGAACCAGTGTGAAAAATTTAAAATACAATGTGACATTTCTCTAGTAGAATGTAAGCTTCATGAGGGAAAAGACAACGCGTCTCCTTCCT
GTATTCCTAGCACCCAGTACGGCACCTGACACATAATAGTGACCTTAGAAGAATATTTAAGAGTCATTGAGTAAACATTTTGTAGAGCTG
TCCATGTTTATTTTCCATTCAGTGTTTACCAGGTGTCTGCTATTTGGACAGTCACTTCATTGTTCATTAGTACATGACTTTGGTAAATAT
ATCTCCTGTGAAGAGAAATATTATAACTACTATGGCATTCAACACTGGTATTTCAGTTACTCAACTAATCCACCCACTGATGGAGTGAAC
CTTGAATTAAATGCTTTGAAGAATAAAGTGAATCTTGATAAAAATCAAAGGCTGAAGAAATCTTGTTTGACAGAAGGCATGAACAAAAAT
GCTAAAATTAATACTGTTTGTGGAGAAACACTCATTCCACCGCAGACTAAATGGAGTTCATGAGTATCAAAATGCCTATGTGATCAAAAG
GCAGAAACAGCTTCTTTTTACTAGGTCTGTTAATATTCCAGGACTCATAATATTGTGCCTACATGAGCACCTGTGTTTGTGGTAACTCAA
AGTATTTGAACACCTTATCTCATCCAACCTCAAATTTCCTGTGAGGTATTTAAGCACCGAGAGCTCTTGGTACTGTTTTCAAGATGAAGC
AGATGAATTAGAGAGGCTGTTCACACACCAAATTTCACAGAAGCCTATGGAGGAAATGACGGGGAGACTTACCAGTTAACACCCAGTTGC
AGAAATCAATGTCAGAGCTTGAAAGGACCTTATAAACCCCTGATCCAATGTGGACTTTCCTAGTAAGACTTCTGTTTGCAGTGACTTGGT
TCATTTCACCAACCACAAGAATTTTAAGTAATTTTTAATCATAAAAGTAACATAGAACATAGTAATACATATATACGTACATACATGATA
CAGAAAGGTATCAAAAAACAAAAACATATATTACTTCCTCCTCTAACATTCCAGTGCCAGTTTCCAAAGATTCCTATTACCCAGAGGTAA
CCACTGTTAATAATTTTTAATGTATATTTCCAAAAATTTTTTATGCATTTAGAAATGTGTGCATGTGGGTGATGGGTGCACCAAAATCTC
AGAAATCACCACTAAAGAACTTACTCATGTAACCAAACACCATGTGGTCCCCCAAAAACCTATTGAAATAAATAAATAATAACATAATAA

>50983_50983_4_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000348428_RTKN2_chr10_63959620_ENST00000315289_length(amino acids)=368AA_BP=258
MPDLFFRPCLRGSEASGRCPGAEARDGAGGSPGSPGSPARAMSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAP
EGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVL
AGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQSQWKHCCEELMKI
EIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLP

--------------------------------------------------------------
>50983_50983_5_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000348428_RTKN2_chr10_63959620_ENST00000373789_length(transcript)=6265nt_BP=907nt
CGAGGCTCCGTGCCCCGCCCCCCGGGTGCCCCGCCCCTTTGCGCGGCTGGCGCGGCCAGCAGGCCAGGCTCCCCTCGGCAAACCTGTCTA
ATTGGGGCGGGGAGCGGAGCTTCCTCCTCTGAGGGCCGTGCCGCGCTGCCAGATTTGTTCTTCCGCCCCTGCCTCCGCGGCTCGGAGGCG
AGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACGGGGCGGGCGGGAGCCCCGGCAGTCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTG
GGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGCCCCTCCGGCCGGCGCGACCCTCAACCGCCTGCGG
GAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCAGGCGCCCGAGGGCCGGGGCTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGC
GGGCGCCTCCGCCTCAGTTGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGAGCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGAAG
TTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTATGGAACACACTGAAGTTCTTCAGCTTCTCAGCCCC
CCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTTTGTGAAACTGTGTTGCCGGGCAACTGGACATCCT
TTTGTTCAATATCAGTGGTTCAAAATGAATAAAGAGATTCCAAATGGAAATACATCAGAGCTTATTTTTAATGCAGTGCATGTAAAAGAT
GCAGGCTTTTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTGGTCACAGCTGGATGTTTGCGACATCCCAGAGAGC
TTCCAGAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTTTGTTCTTGACAAAAGAG
GCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAAAAAAAATTGAAGAGACA
AATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACCATCAAATGGTCATCCAG
AAAAAGGTACTGTATCCTGCAAGTGAGCCATTACATGATGAAAAAGGGAAAAAGAGACAAGCTCCCCTTCCTCCTTCTGATAAACTTCCA
TTCAGCTTAAAATCACAGAGTAACACAGATCAATTGGTTAAGGACAACTGGGGAAAAACAAGTGTATCTCAGACATCGTCTTTGGATACC
AAACTATCAACTCTAATGCATCACTTACAGAAACCAATGGCTGCTCCTCGAAAACTTCTGCCTGCCAGGAGAAATAGATTAAGTGATGGT
GAGCACACAGACACTAAAACCAATTTTGAAGCCAAGCCAGTGCCAGCTCCAAGGCAGAAATCCATCAAAGACATTCTGGACCCTAGATCA
TGGCTGCAGGCACAAGTATAGAAAACTCTTAATGATAAAACATTTAACAAAATCTATAACTGTGAAGCTTAATTCAGAGGCATTATAGAA
TAATGTGTAATTATATAGGTAAATATAGTGATTTATACCAATAATTAATAAGCTATTAGGTATAGAAAAACATTTTATAATGAAGAAGTG
GATTTCTCTTTTACTCCTGATTTGCAGAATGTAAGTGATTTCTCCAGCAGTGTGCAAGAGGCAGTTTCTAGACAATATCCTAATTGTTGG
AAGGGTTAATTTATTCCTGAATTAGTACCAGGCAGTGAATAAGCCCTAGGCAGAATAAAGCATTAAAATTTCTTTTGGGGAGAGACTGTC
TAGTAATTTAAAATGTGTTAAATATGAACCATATTCTCATTGTGAGAATTTTAATACTAATGGAATGTTTCAAAGGTTTTATTCAAACCA
CAAATTATAGAATCCACCCAAGAAAATTTTCTTAGCATTCTGGAATTCTCATCTAATGGTTCACTGGCTCTCATCTATTGTTTAACTCAC
TAGTTTATAGGCCTGACCTTTTAAATTCCTGGGATAAATTTTAGAATATTAAATTCTTCATCTTTAAAGGGAATTTGTAATGTGCTATTC
AAACTTGTTTCCTTGATGAGCCCTGAAATACTGTTGACATTAACTTTCATAAATGAAGCATAACACTTACTAGTTTAGAGAAATGGTAGA
TGAAATGCTCTTTACATTCAATTTTCTGTGTGTGGTGCTAATTTCCATTGTGACTTTGGAATTTAGGGAAGTGAGTAGCTGATCAACACC
TTAAAATTCATTTAATACTTATTTAAAAAGAAGATGAGAGATTCAAAAATATCAGAAAAGTTGGCCATGGTAAATAATTTTCAGAATTCT
TTTTTAAAATTTTAATTAGATTTCCTTTTCCTAGTAAGAGTTGATGTCTGCTAGTGGTATTTTTCATTAAATGTCATATTCTTACAACAG
TGACATTGGAATCATTTCCATAGGAGGTAATTTCCATAGCAACTAATCATAGTGACCCAAACAGGATTATAAAGTCAAGTGAGGAATAAA
TAGCAGAAAAATACCTTAAAGGAACAAAAAATCCATTTTTTATAATAATGCTTTTTGTAAACAAGAGCAGAACAGTTTTAAAAATCTAAT
TAGAATTTCCAAATAAAACAGTTTCCATAAGGTGTCAGCAACAGCACTAAAAATCTCAAATCACACTGAACCCTAAATGTCATTGCAAGA
AATAAAAATTTAAGAATTAAATTGCTGCCCTGTGTATAATCTCTTGAGATCTTTTTAAAGCTAGCAAGAACTCTATTTGGATCAGAACTA
CATTATTACAAAACAAAATGAACACTTGACCAAAAAACCACATTAATTTAAATGGAGCCTTTCATTATTTTCAGATAGCGGGGTCTTTTC
CATTTATAGAGAATGATGTAACTGCCAGGACACTTTTGTGTTTGCCCAGGACTCCTAGTAAGAATTGAATCTTGAGGGAGTAATGATAAC
AAAAGGTTTCTTGTGACTGGTAACATCAGGACAGACAGAGTTTTTGGTGAGAAGAAAGTACTATATGCCTGCTTGATAGCATGTAGAGAT
CATCACATGTATGGAAACCTTAAAAAGTAAACTTATTTTTTCTAACTAGAAGGCTCTCATAAGTTTCTGTTATGATTGCCATTTCAATAA
ATGACATTAAAAATCTAAAGGATATTATTGTTTGAATTTTTGGGTTATTTTTTAAAACTTCATTGCTGTTTTTGACAGCATTTGTGACTG
TCATTGCCACTAAATTATTGAGCTAGAAGATGCTGCAGGGAAAATTGTTTTGAAGCTGGCATCTAAGCATTCTTTTTTTTTTCCTAGTTG
ATGCCTTCCTTTATTACAAATCAGTATTAAAACTTCCAGATTATATTCTTGTCATTTTTCCTCATGCAGATAACAGCAGGAAGGACTTAA
GGTGTATAAGAAAAAGAAAGTATTCATACAGAAATTACCTAGCAGTTGTGCCCTCAGAGTAGAACTTTGAAACAGGACTGAAGCCCTTTT
TACCTAGAACCATTTAAAAGCCTGAGCAAGGACCACCACCCCCTCCCCACCAAATTATTCGGTCTCTTTCTGGGGGGCCCAGCTTACTGT
ATGTTACAAGTCTTTGAAATGGGTCTGGTGTCTTCAGCTCCTGAAATGCTAATTTACCCCTTACCTAAGGAGTGTAGTTATAATACAGAG
TTGGTTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCATTCCCTCTGTCCGTCTC
TCCTTCCCTCCTTCCCTCCTTCCTTCCTTTTTGTCTTTGTTTCTTTCTCTGGCCCCCTGTCCTCTCTCTCTGTCTCATCCCCTTTTCCCA
CTTTCCTTCTGTCTCTCCTTCCTCCCTTCCTTTACAGTTTAAAAAAAAAATCTAAAAATAGTTAAGCACTGTGTCAAAGAGTGTTTCAAA
AGAATTGTTTGTTTTCTCATTTCTTAAACCAGAAGTTTATGACAAATAAATATGCCATGTAATATGAAAGCTGCTTCAGCTTTTTATGAG
CTTTCACATTCCTTGTTTGTCCTTTTAATTTGTTTCTTGATATATGAAGACTATAAACTTGAAACAAAGAGTTAGCTGTCAGCTCTTGAT
AATATAATTGGGGAAACAGAATAGATATTTTATGATATGATAATTCTGATGATCTAAAGATAATGTCTTAGACAATTACCTTTACATTTC
AAGCTCTGGGATATAAATTACGTAGTCAGCATTAAGATAGTATTATTTTTAATTGCTACTAAGTGGTAACTTTTGTATTTTAATATCTTG
CAAGGGCAAAGAAGGCATTTTTAAAATTCTAAATGCACACCTCCTAAGGTAAATAGTCTTTCAAAAATATCAGGCGTGCCAACTCTTGCT
GAGTTTTGTTAAATCCTCCTTAACTGTCTGCAGTGCCCCCTGACTTCTTTTAAATGGATGTGAATATATGTGGAAAACTAAATCCATTTA
TTATAAATGCCTTATCTTTACCCTTTGGGATCTTACTAAATGCATTTTACCTGCTACTATTTATTAAAAATGGAAGCTGTCTTGAATTAG
AGATACCTCACGTAAGGTAGGTTAAGCAGTCAAGTATTTCTTTAGGCTTATGTTCAGCACCTCAGCCCCCTACTGAGAAGTTAATTAATT
CAGTCCAAAATGAAATTATAGGGCAGTTTGGTGCAATTTATGTTAAATGCCATTTGAATGTAATCACCTGTGTTACCACGAATGAGGCAC
AACTATACTACATGGACAGAGTACTGCATTGCACCATGAGCAAGAACTGCTCTGCAAGAAAAATATCTGTCCCTGTGGTCTGAATTTATC
AAAACTCATTTTCTTGTTAAAGAGTGAATTATTGAATAGTAATTAAACTTTAACTGATGACCATTTATATTCTAGTAGCCATCTTCACTG
TTAGTCTTAAATTATAATGTAAAGTTGACATTTTCCCCTTACATTTCAAAGGCATCACTATTTTTAAATGTTTACATATGTTTACATGTT
TGTGTGCAACTGCTTCATTGCTATTAATAGTTAAATGAAATCTGCATATTCTGGATCATAGATGTTCTTAGTTAACTCTGGGAAAGATGT
TACCTTTGGGTTTTTAAAAGACAAGTCATCATTTGAAAATATATTAGGGTGTGTTGATTTTCTGACATGCTTGTGTAATTGGCTTTGTTT
ATAATTTTTATTTTTTAATATGGGTCAGACTTTTGGATTAAAAAGTATTATATCATGGACATACATTTTTTAAAGTACCAAAGGTATTTG
GTAAGCGAGCCCAAGTCATGTAATTGAAACTTCTGTACATTAAAAGAACTGATTCATGAAGACGTTTTCTAACTTTTTCTCTTTAAGTGC
TCCTCTAGACTAGACTGATTGAAGTAGACAGTGTGGTGGAATCAGTTTAATCAGAAAAAGACATACCAAGTAGCTGGTGCTAATTATTAT
AAGACTAACATTCTGATAAGCCATGGTATAATTAACATTATTAAAATGTTTACATATAATCCTTCTTAAAGTATACTCTTTTAAAAATCC
ATTGACATAACCTTACTTTTAGTTTAGTGATCCAGAATTTCCCCAGAGCTTAAGCCACTGCAGTAAATTAGGTACGTAGGATATTCAGTC
GCTACTAGCCACAAGGAGTCTCCTTATTTTAATGTACCTCCCTCAGTACTTTATTCCTGCAGAGCGCCTCAGAGTGGGGGAGAGAAATGA
GCAATCCTGGCTCAGTTGGATTATTTCAGCATTTTATTTCTAAATCTGTAGTGTGATCAGAAATATTTAAAATTAAAAAAATACTTTACA
GAGAGAGGCCTACTAATCAATGTGCTTAGAGAAACAAACTACCTTTACATTCAATTAACAACAAAAAAAGTTACAGAAATTTTAACAAAC
ATTTTTCTTTATCTGAGTATGGGAGAAAATACTAATGCTGACACGTTTAATAATTAGAAAAGATCATTCCAGATCTTATGGAAAATTGTG
TTTTAAATTCCAGCAGTTTGCTCTTGAGACATGGTAATCTCTTAATGTAACTACTAAAGGAGAGGTAGATTGAAAAGATCTTGTATATAC

>50983_50983_5_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000348428_RTKN2_chr10_63959620_ENST00000373789_length(amino acids)=471AA_BP=258
MPDLFFRPCLRGSEASGRCPGAEARDGAGGSPGSPGSPARAMSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAP
EGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVL
AGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQSQWKHCCEELMKI
EIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEK
GKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVP

--------------------------------------------------------------
>50983_50983_6_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000348428_RTKN2_chr10_63959620_ENST00000395265_length(transcript)=1242nt_BP=907nt
CGAGGCTCCGTGCCCCGCCCCCCGGGTGCCCCGCCCCTTTGCGCGGCTGGCGCGGCCAGCAGGCCAGGCTCCCCTCGGCAAACCTGTCTA
ATTGGGGCGGGGAGCGGAGCTTCCTCCTCTGAGGGCCGTGCCGCGCTGCCAGATTTGTTCTTCCGCCCCTGCCTCCGCGGCTCGGAGGCG
AGCGGAAGGTGCCCCGGGGCCGAGGCCCGTGACGGGGCGGGCGGGAGCCCCGGCAGTCCGGGGTCGCCGGCGAGGGCCATGTCGCTGTTG
GGGGACCCGCTACAGGCCCTGCCGCCCTCGGCCGCCCCCACGGGGCCGCTGCTCGCCCCTCCGGCCGGCGCGACCCTCAACCGCCTGCGG
GAGCCGCTGCTGCGGAGGCTCAGCGAGCTCCTGGATCAGGCGCCCGAGGGCCGGGGCTGGAGGAGACTGGCGGAGCTGGCGGGGAGTCGC
GGGCGCCTCCGCCTCAGTTGCCTAGACCTGGAGCAGTGTTCTCTTAAGGTACTGGAGCCTGAAGGAAGCCCCAGCCTGTGTCTGCTGAAG
TTAATGGGTGAAAAAGGTTGCACAGTCACAGAATTGAGTGATTTCCTGCAGGCTATGGAACACACTGAAGTTCTTCAGCTTCTCAGCCCC
CCAGGAATAAAGATTACTGTAAACCCAGAGTCAAAGGCAGTCTTGGCTGGACAGTTTGTGAAACTGTGTTGCCGGGCAACTGGACATCCT
TTTGTTCAATATCAGTGGTTCAAAATGAATAAAGAGATTCCAAATGGAAATACATCAGAGCTTATTTTTAATGCAGTGCATGTAAAAGAT
GCAGGCTTTTATGTCTGTCGAGTTAATAACAATTTCACCTTTGAATTCAGCCAGTGGTCACAGCTGGATGTTTGCGACATCCCAGAGAGC
TTCCAGAGCCAATGGAAGCACTGTTGTGAAGAACTTATGAAAATTGAGATTATGTCACCACGGAAACCACCTTTGTTCTTGACAAAAGAG
GCAACCTCAGTCTACCATGATATGAGCATTGATTCACCTATGAAACTTGAAAGTTTAACGGATATAATACAAAAAAAAATTGAAGAGACA
AATGGGCAGTTCCTTATTGGTCAGCATGAAGAATCCTTACCACCTCCTTGGGCCACACTCTTTGATGGTAACCATCAAATGGTCATCCAG

>50983_50983_6_MALT1-RTKN2_MALT1_chr18_56367823_ENST00000348428_RTKN2_chr10_63959620_ENST00000395265_length(amino acids)=368AA_BP=258
MPDLFFRPCLRGSEASGRCPGAEARDGAGGSPGSPGSPARAMSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAP
EGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVL
AGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQSQWKHCCEELMKI
EIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKNNSNQLHNLQKLP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MALT1-RTKN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MALT1-RTKN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MALT1-RTKN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource