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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAN1A2-VANGL1 (FusionGDB2 ID:51075)

Fusion Gene Summary for MAN1A2-VANGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAN1A2-VANGL1
Fusion gene ID: 51075
HgeneTgene
Gene symbol

MAN1A2

VANGL1

Gene ID

10905

81839

Gene namemannosidase alpha class 1A member 2VANGL planar cell polarity protein 1
SynonymsMAN1BKITENIN|LPP2|STB2|STBM2
Cytomap

1p12

1p13.1

Type of geneprotein-codingprotein-coding
Descriptionmannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IBvang-like protein 1KAI1 C-terminal interacting tetraspaninloop-tail protein 2 homologstrabismus 2van Gogh-like protein 1vang-like 1 (van gogh, Drosophila)
Modification date2020031320200322
UniProtAcc

O60476

.
Ensembl transtripts involved in fusion geneENST00000356554, ENST00000482811, 
ENST00000474344, ENST00000310260, 
ENST00000355485, ENST00000369509, 
ENST00000369510, 
Fusion gene scores* DoF score12 X 11 X 7=9248 X 8 X 4=256
# samples 219
** MAII scorelog2(21/924*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAN1A2 [Title/Abstract] AND VANGL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAN1A2(117984947)-VANGL1(116224985), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAN1A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VANGL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A0A6-01AMAN1A2chr1

117984947

-VANGL1chr1

116224985

+
ChimerDB4BRCATCGA-A8-A0A6-01AMAN1A2chr1

117984947

+VANGL1chr1

116224985

+


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Fusion Gene ORF analysis for MAN1A2-VANGL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000356554ENST00000474344MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
In-frameENST00000356554ENST00000310260MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
In-frameENST00000356554ENST00000355485MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
In-frameENST00000356554ENST00000369509MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
In-frameENST00000356554ENST00000369510MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
intron-3CDSENST00000482811ENST00000310260MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
intron-3CDSENST00000482811ENST00000355485MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
intron-3CDSENST00000482811ENST00000369509MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
intron-3CDSENST00000482811ENST00000369510MAN1A2chr1

117984947

+VANGL1chr1

116224985

+
intron-3UTRENST00000482811ENST00000474344MAN1A2chr1

117984947

+VANGL1chr1

116224985

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356554MAN1A2chr1117984947+ENST00000355485VANGL1chr1116224985+929316857352447570
ENST00000356554MAN1A2chr1117984947+ENST00000369510VANGL1chr1116224985+929316857352447570
ENST00000356554MAN1A2chr1117984947+ENST00000310260VANGL1chr1116224985+292316857352447570
ENST00000356554MAN1A2chr1117984947+ENST00000369509VANGL1chr1116224985+292316857352447570

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356554ENST00000355485MAN1A2chr1117984947+VANGL1chr1116224985+0.0004487930.99955124
ENST00000356554ENST00000369510MAN1A2chr1117984947+VANGL1chr1116224985+0.0004487930.99955124
ENST00000356554ENST00000310260MAN1A2chr1117984947+VANGL1chr1116224985+0.0021805320.9978194
ENST00000356554ENST00000369509MAN1A2chr1117984947+VANGL1chr1116224985+0.0021805320.9978194

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Fusion Genomic Features for MAN1A2-VANGL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAN1A2-VANGL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:117984947/chr1:116224985)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN1A2

O60476

.
FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN1A2chr1:117984947chr1:116224985ENST00000356554+6132_36316642.0Topological domainCytoplasmic
HgeneMAN1A2chr1:117984947chr1:116224985ENST00000356554+61337_57316642.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN1A2chr1:117984947chr1:116224985ENST00000356554+61358_641316642.0Topological domainLumenal
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038139_151270525.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038173_182270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST00000310260381_117270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038204_222270525.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038244_524270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538139_151270525.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538173_182270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST00000355485381_117270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538204_222270525.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538244_524270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927139_151270525.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927173_182270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST00000369509271_117270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927204_222270525.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927244_524270525.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038139_151268523.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038173_182268523.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST00000369510381_117268523.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038204_222268523.0Topological domainExtracellular
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038244_524268523.0Topological domainCytoplasmic
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038118_138270525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038152_172270525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038183_203270525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:117984947chr1:116224985ENST0000031026038223_243270525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538118_138270525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538152_172270525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538183_203270525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:117984947chr1:116224985ENST0000035548538223_243270525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927118_138270525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927152_172270525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927183_203270525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036950927223_243270525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038118_138268523.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038152_172268523.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038183_203268523.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:117984947chr1:116224985ENST0000036951038223_243268523.0TransmembraneHelical%3B Name%3D4


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Fusion Gene Sequence for MAN1A2-VANGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51075_51075_1_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000310260_length(transcript)=2923nt_BP=1685nt
AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG
AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT
CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC
CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG
GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT
ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG
GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA
ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT
CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA
CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT
TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA
AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT
GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC
CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT
GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC
AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT
ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT
GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCT
GAGAAACTCCTTCCTGCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTATCCAGCGAGCAGCATTGGTGGTC
CTAGAAAATTACTACAAAGATTTCACCATCTATAACCCAAACCTCCTAACAGCCTCCAAATTCCGAGCAGCCAAGCATATGGCCGGGCTG
AAAGTCTACAATGTAGATGGCCCCAGTAACAATGCCACTGGCCAGTCCCGGGCCATGATTGCTGCAGCTGCTCGGCGCAGGGACTCAAGC
CACAACGAGTTGTATTATGAAGAGGCCGAACATGAACGGCGAGTAAAGAAGCGGAAAGCAAGGCTGGTGGTTGCAGTGGAAGAGGCCTTC
ATCCACATTCAGCGTCTCCAGGCTGAGGAGCAGCAGAAAGCCCCAGGGGAGGTGATGGACCCTAGGGAGGCCGCCCAGGCCATTTTCCCC
TCCATGGCCAGGGCTCTCCAGAAGTACCTGCGCATCACCCGGCAGCAGAACTACCACAGCATGGAGAGCATCCTGCAGCACCTGGCCTTC
TGCATCACCAACGGCATGACCCCCAAGGCCTTCCTAGAACGGTACCTCAGTGCGGGCCCCACCCTGCAATATGACAAGGACCGCTGGCTC
TCTACACAGTGGAGGCTTGTCAGTGATGAGGCTGTGACTAATGGATTACGGGATGGAATTGTGTTCGTCCTTAAGTGCTTGGACTTCAGC
CTCGTAGTCAATGTGAAGAAAATTCCATTCATCATACTCTCTGAAGAGTTCATAGACCCCAAATCTCACAAATTTGTCCTTCGCTTACAG
TCTGAGACATCCGTTTAAAAGTTCTATATTTGTGGCTTTATTAAAAAAAAAAGAAAAATATATAGAGAGATATATATCTATGCCAGAGGG
GTGTCTTTTTTAAAAATTCTTCTTCATTGCTGACTGAAACTGGCAGATGATTGACCAGTATCCTTTGACCATCTGCACTTTATTTGGAAG
GAAGCAGGGGCTGTCCACCCTGAAAAAGAGTGACTGATGACATCTGACTTTTGTCGATGGGACTTCTCAAGAAGCCATTCCTTGGAGCTT
CTGTTACAGCTGTAAACCAAAGTGGAGCTGGTGCTTCTTGGGAGCCTCGCCTTACAACTAATTCCTGCCTTTCGTCCAGTACCAAGTCCC
CCGTTGCTTCTGGTCAGCCCACTTGTAGACTTCCAGGGGACACATCTTTATTCTGTTTCAGGAAACCAGTCACGACACGTCCACATATGT

>51075_51075_1_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000310260_length(amino acids)=570AA_BP=316
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR
FIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNV
DGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARA
LQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNV

--------------------------------------------------------------
>51075_51075_2_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000355485_length(transcript)=9293nt_BP=1685nt
AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG
AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT
CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC
CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG
GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT
ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG
GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA
ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT
CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA
CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT
TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA
AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT
GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC
CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT
GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC
AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT
ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT
GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCT
GAGAAACTCCTTCCTGCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTATCCAGCGAGCAGCATTGGTGGTC
CTAGAAAATTACTACAAAGATTTCACCATCTATAACCCAAACCTCCTAACAGCCTCCAAATTCCGAGCAGCCAAGCATATGGCCGGGCTG
AAAGTCTACAATGTAGATGGCCCCAGTAACAATGCCACTGGCCAGTCCCGGGCCATGATTGCTGCAGCTGCTCGGCGCAGGGACTCAAGC
CACAACGAGTTGTATTATGAAGAGGCCGAACATGAACGGCGAGTAAAGAAGCGGAAAGCAAGGCTGGTGGTTGCAGTGGAAGAGGCCTTC
ATCCACATTCAGCGTCTCCAGGCTGAGGAGCAGCAGAAAGCCCCAGGGGAGGTGATGGACCCTAGGGAGGCCGCCCAGGCCATTTTCCCC
TCCATGGCCAGGGCTCTCCAGAAGTACCTGCGCATCACCCGGCAGCAGAACTACCACAGCATGGAGAGCATCCTGCAGCACCTGGCCTTC
TGCATCACCAACGGCATGACCCCCAAGGCCTTCCTAGAACGGTACCTCAGTGCGGGCCCCACCCTGCAATATGACAAGGACCGCTGGCTC
TCTACACAGTGGAGGCTTGTCAGTGATGAGGCTGTGACTAATGGATTACGGGATGGAATTGTGTTCGTCCTTAAGTGCTTGGACTTCAGC
CTCGTAGTCAATGTGAAGAAAATTCCATTCATCATACTCTCTGAAGAGTTCATAGACCCCAAATCTCACAAATTTGTCCTTCGCTTACAG
TCTGAGACATCCGTTTAAAAGTTCTATATTTGTGGCTTTATTAAAAAAAAAAGAAAAATATATAGAGAGATATATATCTATGCCAGAGGG
GTGTCTTTTTTAAAAATTCTTCTTCATTGCTGACTGAAACTGGCAGATGATTGACCAGTATCCTTTGACCATCTGCACTTTATTTGGAAG
GAAGCAGGGGCTGTCCACCCTGAAAAAGAGTGACTGATGACATCTGACTTTTGTCGATGGGACTTCTCAAGAAGCCATTCCTTGGAGCTT
CTGTTACAGCTGTAAACCAAAGTGGAGCTGGTGCTTCTTGGGAGCCTCGCCTTACAACTAATTCCTGCCTTTCGTCCAGTACCAAGTCCC
CCGTTGCTTCTGGTCAGCCCACTTGTAGACTTCCAGGGGACACATCTTTATTCTGTTTCAGGAAACCAGTCACGACACGTCCACATATGT
ATTTGTGTATGTTAATGTCCAGTATCACATCACCCATGAAAGTCGTGGGCAGTTCAGGAGATACCTGCCTTCATCTTTGTTCTTTGTTGC
CTTAGGTTCTTCAGAGAAAGATCACAACAAAAAATGTACACTGTCGTTTACAGCTATTAAGTGATTTGATTTTGTTTTTTTCCCAAAGAG
AAAACCTACCTGCCCTGTTTCTGATCCCACCCCTCTGCTGGCTTGAAGCAGGTAACCCTTTCCCAGCCCTGCAGCTGCCCACCTGGCCTC
CATGCCATCCTGCCCCCACCTGGCTGGCAGCCCTGGCTCTCCATGTGTGCCCTCCGGCTCTGTGTGAAGCCTCAAGTCAGTCCCAGCATT
GTTTCCATAGGGAAGTGTGGGGTGCCCAGCAGGTAAAGCACAGGGAGAGAGGGCAGTGGGAATGCCACCTTTAGGCTGCAGCAGGAGCCC
CACACTGCCCAGTTTTCCTCCCCACTGTTCTACACCAACCAGGGGAGACTAACACTGTGACTCTGGGATTGGCAGGTGCAACTTGGAGCC
ACTTAATTTCCTGGGGACGTAAGTTCTTCCCAAGCTTAGAGCAAGCTGCCCTGCCAAAGGAGACCAAACCATGCCAACCACGCTGGCAAC
TGCTGCTGTCCAGTCCCTGTGTTTTCTGACCACCGTCACTGTGCAACTCATCGCCTCTGCCACTTAGGACCAGGAAAGAGGCTGGTTTTG
CTCCCACTCTTAGTTGCTGATAAAGTGGGGAGAAGGAAAATGGACACTCTACAGAGTTTGGGGAAGGGAGAGTAGGGAGCCCATCTTGTC
CAGAAAGATTCATCTGTGGTCTGTCTGTTAAACACAGCTGATTTCAGTGGGCTTTCCCCTGGCCCTGGGGGAGCAGACACTGACTGGGTT
GTGGGCAGAGGAGCCATCCTGGCGGAGCCCTGCTGCAGGGGAGCTCCTTCAGGAGCCCCATCCGGACCTCTTGCACTGGGCTGCCTTTGC
CTCCATTTGCCTTCCTGTATCTGCAACAAACCTTTTAAAAGTGTTCACTCTTGCTTTTTCCAGTATTTCGGTAATCAGCCATCTTGCTGT
AGTACAGGATGACATTGTCGAATGCTCTTTGTATGTGTGCACACCCCCTTACTCCCTTACTGCTTCATACACTCCACAAGTGGTACAGTA
TTTTGTGTCATTGTAAAAATCAAAATTGGCTTTGGATCTTTGTAATACACCTGTACCTGAAAAAGTAAACAACATTCTTCAATTACTAGC
CTTCAGCTTGAAAAGACATGCTGGAGAAGAAGGAAGGGGGAACCCATAGGTGTGGCGTGGAGCCAAGATGTACTATTCAACTATGTGTTT
CTGTTTATAAAAAACACATACCATGGAACCATGGTGCTTTTGTTCTTAGTTTTTGCCGTTAGATCCCTTCAAACTGGAAGTTCCTTACAA
TATCTTTCTCAGGAAATATTTTGGGAAATGGGGTAAGAGATGGCAAGTGTGAGACGGGCTGTGTCAGAGGTTGCTACGTCATGGATACAG
TGCAGTTCCAAGTGCCATAAGTGTATGTACATATAGTTAATAATGACACTGTTCATCACCATTCTAAAATACTGTTCTTCCAACCCTATC
TTCAATGACCAGTCCAGAAGGGGTTAAGCTGGATTCATTTGCTCTGGCATGTGCATTCCCAGCAGGGTGAAGAAAGGTTTAAATTAAAGA
ATTTATTTTCTCTCTCCCCCTTCCTCTTTCTCCCAGTCTTTGCATAGGAGAATGTTAGACATTCAGAAATTACTGTTTCTGTTTTAAATT
GAGTATTGATTTTTTTATATTGACTTTGTATTGAGTTCTTTTTGAAAGAATAACAAAATAAAATGCAGGATCTTTGTAAAGCCTTTGCAC
TTTCAACCTCTTTATAGCTTGAGTTACTTTTGCAGTGGGAACAATGTAAATGACATTTAAAAGATTTAAGGTTTCAGAAAGCTGCATCCC
ACAATTGAACACAATGCATTTTTATTTCAATTCTTGGAACTGGTAGGCTATTCTTTTTAAAAGGGGGTAAACTTCGCCCTAAGGCTGGTA
GAATGTATGTTCACATTATAGTAGACAGGATTTCATTTGCCTTATATGTTTATAGATTTTTTATAATTTTCATCCTACGTTATTAAAATT
AGAGCATTGAGTGTTAAAGAACTTAATGAGGAGTCTATATCTGAGATTGCTCTCTTCCCTGGTGATGTTTTAACTGGTAGATAATTTGTT
CTTAAATATGTACTTTTGAAGATAGGACAGTTTTTATAGTCCATGAACTGAATGTTAAAAAGTTCTGTATGCATTCTCAGAGAGGATTTT
AAAGCTATATAGTTCATCCATCCTTTGCATTATCAAAATGTTAAGTCAAATCTGTAATACTTTGGCTAAAATTCATAAAGTAAGCCCTAG
AGAAAATACTTGACCACCAAATTTTTGCCCAACTATCATCACCTCCCTTCCCCCGCCTCTGTTCTTGCCTTTTGACATCTACATGGAAGA
CAAGTTCTTTACAGCAAATGGTAAGAGGCAGGTGACCTGGTGTGTTTGCTGTGTTGTAGTTCATTGCCTGGGGCTTGGGACTCCTTTTTT
AATGGAGAGACTAGCTGTGCAGGTGTGTGTTGGATAGGGATAAAGTGCTCACCCCTGCCCTCTCTACAGTAGTTGGTGGTAGATTTCTCT
CTCATTTTGCCTCATAATCACTTTCGAGTGCATGTATTTACCTAAGGGCTGTAGCTCTGTGGGATGCTACCAGCATATTGGACTGACAGA
AATTGATTACCTTGCCACTCCAACCTACGTACTGAGTGAGTGCTCCAGCCACTCAGTGAAACCAACAAAAGTGAGTCCTTGGTTTACCTT
CCAATCTGGGTCCTGCTGTGTAAGTATCCCTAAGTGGGGATGCATATTTGTTTGTGCGTTTTTATTTCCATATATGTGAGCATTTCTCTG
AGTGTATTACCAGACGGATAGCACATTTATATGTCAGACATCTTAACATCTGTGTTATCTGTAGCAGGTGTGTAGCTCAGCAGATACGTG
TCATTGTGTATATAGCTGAGTGTGTGAGGGTGTCTGTGTTTCTGCAGTCCCCTGTGTTTGAGAGATGACTTAATAACCCTGTGTTTTGAG
AGGTCGCTCTAAACCAGTGACTTTTCCCTCCCCTGCTTTATTCCTTTCCCTCACTGACACTGGCTTCTCCCGCTAGAGTAAATGGCTTTA
GCACAGCACTGTCTTCTGGGGAGCCTGCTGTCCTGCAGGCAAGTCCATTAAACTCTTTCTTGCTTTAGGACTCTGAAAACAGCAAGAAAC
AAACAAACAAAGGTCAAGCTCTAAGAAAATTACTGCTCAAACTTCACTACCCTGGAAGCCTTACTAGATATTTCTTAAGGTAACTTAAAA
ATTGGGCTTTATTTTTAAAAAGTGATAGGTTACTTACAGTAGCACAGAAATGTTAGCATATTTATTTAAATAGTCCTGCAGCAGAGACCC
TGCGATTGTAAAGTGATTTAAGTATTTCTGGGTAGTGTTTGTGATTTACGGATTTGTTACTGAAAAACAAAAAAATCACTACTGTGAATT
TACTACTATGTAACCTTGTGGTCGTATTTCATTATAAATAAAATAAGAATTGCTCTTCTGCCCACCGTTCTTGATTGGTATTCAGTGCAG
TAGCGAAATGAGATAGTTTAGACACTGTTGAAATAACTGCATTGAGCTTTAACCAAGTGTATGCTCAGAAAATTCAGTTTTGGATCACAT
TTTGACAAAACATGTTTTGGTCAAAGAAAGGAAAGGCTACTAACACATTTATCAGGTAATGTATGTCACAGTCCGTGTTCCACCCAGCCT
TGTTATCCCCACATTCTTTCAAGATAGGAGTCATCTTGGTTTTTCGGGTGAAAAACGGAAGGTCAGAGAGGAAGGGGCTTGTCCAAGGTC
TCATGTCTGGTTAACAGAATTTCAAACTAGATGTTTGATTCTAACCCCTCAGTCCACTGTACCTTGAAGTATGGTCTAAATGATTCGGCA
CTTCTGGATGTTGAGGAAGGACCTAGAGACACATCCTTGAACTAGAACCTGGGGTGAGAGTTCATTGGGAGGCAGGATCTCTTCTTTCAC
TTTGGATTTACACCTTGTCCCTTGGAAAGCTTCTCCACTATGCTAGCAAATATCTTAGGATATTTGATGGAAAGAACTTGAGAATCCCTT
CTGGAAAACCCAGCCTTTCAGTGTTAACACCTGCTGCAAGACAGGGATGCTGTTGTTCTGGCAGCCCCCCTTTGCTTTTGCCTGGCCCCA
CCTTCTGCTCCCACTCTGCTGGCTTGGGCAAGATGCGTGCCTTGGGCCTTGGGTGCAGGGAGGCAGGCAGGGGCTTGACCTGGCCTCTCT
CTGGTGCCATGGCAACATTATGCCCCAAACTTCTTCCCTGGTTGGAGTGAGAGGGGCTGTCCACAGCCCCATCCTGTGGGGATCTCAAGC
CGGAGTCCCTGGCCTGGCCTCCTTGACGTAGGTGTTCTCAGCAAGCAGTTTGCATCCCACCGTCTTTCTCACACTTGCCCCCAAGACTTT
TGACAGAGCAGACGTAAAACAGGACTCAGAAAACCATTTTTCTCTGTTCCCATATGTAGTAAGTTTTGATTCAGTTGTGCATAAACCATA
GTTTTCTGCCCTGCTGTTTGCTTTCAATGGAAGACAGTAAAGGGAAGATGGTGCTCACATCTCTCCATGTGACATCTCATTAGGAATTAA
GATGCGATGGATTAGAAATGTAAAACTTCAGAATAAAATTAAATTTCAGGGCTCTATAAGTCCCGTTTTCCCAGGTCCTGTTCCGTTTCT
ACGTAGATAACCCAATTTGTTTTGTCTATGAAATAAGCCTCTTTAGTGGGTTGTTTTAGTCTCTCCAACAAAAGAGCAGATTCCTAAAGC
CAGGTGCAGCACTGTGAAAAGTTTCTTTCAATATGGCACCAAGACTCTACCATTTATGTCTCTCTCAGCTTACAAACATCAGCGTTTTGT
CCTTGTCATAGTGGAAGAAAGACACTTACTTTAAGCTTTGGGGACAAAGGTGACAAACCCCAGGCTTTTATCTTAAAAGTGTCTTTGGCA
CTTCTTTTGGCACTGAAATGGTATTTGGGAAGCATTATTTGAATGTACAGTTGTTTGGTTTTGTATGTGCTTATCTTTATCTGAGCTTTC
ACTTGTAGACATGGCCTTTTGTTGTGAAGTTGCTCATCATTTAGGAGTGTTTAATTCTAAAAAGCCTTCAGCCTAAGAAAGCTTCATCTG
TGGGGACCAGAGACTTGTTGCTCAGGGAGTTAGTGATGGGACTTGGGCATCTGATCTGCAGGTGACAAGTTTAGTTCAACTGAAGTTGTA
GGGAATTTAGACAGTTGCACATCATTGCCGTTCTAGGGGCCTTGTAGAAAGATGAAACAGTTGTTTTTCATTTACCAGCACCTCTCAGTT
ATAGAGGTAATGGAACATTCGCTTACTTTTCATCATCATTCTTTAAAAAGGGAACATACAAAAATCTAAACTATGGCAATAATTTATTTT
TATAATAGTTTACGGTAGGCTTTAATTAAATGGCAAACTCCTCTGGGACCCCTAAGTTATGGCGTGATTAGCCAAATTTGATTTCCAACA
GTCATTTATGGCCATAACTATTGCATAGAGTGCAGGATGCCAGCAAAGATGAGGGTGGGGGCAGATACTGGCTCAGTGATTTAACTCACA
TTATAGATGACCCCTTCCTCAACAGAAATGCTACTGAGAGAACCAGAGAGGCCTGGGCCAGGCAGGTCTTATTTGAGAGGAGATTATTTG
ATAATTGCTTTGGTTAGAAGGACTTTACATTTCCTGATTTCAAGTCCAGCACCAATTTAGAAAGTTCAGAGATGAAACCACCTGTCTTTA
CCTGACAGAGTCATAACGGTTTGTGTAAAAATGTGGTCAGGGACCTTTTTTGTTCTTTCTGATTAGTTAATACTGTACATTGTAACCAGG
AGGGGCAGTTTTGCCAACCAGCCTCTGCTCATGGTCACCATATGTGTATGACAAGGCCTGAGTGAGTTCCTGCATAAACTGGGTAGTGGG
CTCTTTTGACACATTTGCAAGCATGTAAATGAATGAATGACACTACCAGCAACCATCTGTACAGGTCCATTTACTTACATTCATAAGGTT
TATGCTATGAAACTTCTTCTCATTGTGATGTCAGTAACAGAGTTAGTGTCTCTGATGGAATAGTGTACCTGTCACCCAAGTTATTTTGTT
CCTTTTTGGGTCCTCCAGTATAATCCCCCCCTCATCCCAATTAACTGTAAAATGTTTTACACATCACATTTTTTATACTGTAAACTTGGA

>51075_51075_2_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000355485_length(amino acids)=570AA_BP=316
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR
FIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNV
DGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARA
LQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNV

--------------------------------------------------------------
>51075_51075_3_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000369509_length(transcript)=2923nt_BP=1685nt
AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG
AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT
CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC
CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG
GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT
ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG
GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA
ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT
CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA
CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT
TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA
AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT
GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC
CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT
GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC
AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT
ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT
GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCT
GAGAAACTCCTTCCTGCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTATCCAGCGAGCAGCATTGGTGGTC
CTAGAAAATTACTACAAAGATTTCACCATCTATAACCCAAACCTCCTAACAGCCTCCAAATTCCGAGCAGCCAAGCATATGGCCGGGCTG
AAAGTCTACAATGTAGATGGCCCCAGTAACAATGCCACTGGCCAGTCCCGGGCCATGATTGCTGCAGCTGCTCGGCGCAGGGACTCAAGC
CACAACGAGTTGTATTATGAAGAGGCCGAACATGAACGGCGAGTAAAGAAGCGGAAAGCAAGGCTGGTGGTTGCAGTGGAAGAGGCCTTC
ATCCACATTCAGCGTCTCCAGGCTGAGGAGCAGCAGAAAGCCCCAGGGGAGGTGATGGACCCTAGGGAGGCCGCCCAGGCCATTTTCCCC
TCCATGGCCAGGGCTCTCCAGAAGTACCTGCGCATCACCCGGCAGCAGAACTACCACAGCATGGAGAGCATCCTGCAGCACCTGGCCTTC
TGCATCACCAACGGCATGACCCCCAAGGCCTTCCTAGAACGGTACCTCAGTGCGGGCCCCACCCTGCAATATGACAAGGACCGCTGGCTC
TCTACACAGTGGAGGCTTGTCAGTGATGAGGCTGTGACTAATGGATTACGGGATGGAATTGTGTTCGTCCTTAAGTGCTTGGACTTCAGC
CTCGTAGTCAATGTGAAGAAAATTCCATTCATCATACTCTCTGAAGAGTTCATAGACCCCAAATCTCACAAATTTGTCCTTCGCTTACAG
TCTGAGACATCCGTTTAAAAGTTCTATATTTGTGGCTTTATTAAAAAAAAAAGAAAAATATATAGAGAGATATATATCTATGCCAGAGGG
GTGTCTTTTTTAAAAATTCTTCTTCATTGCTGACTGAAACTGGCAGATGATTGACCAGTATCCTTTGACCATCTGCACTTTATTTGGAAG
GAAGCAGGGGCTGTCCACCCTGAAAAAGAGTGACTGATGACATCTGACTTTTGTCGATGGGACTTCTCAAGAAGCCATTCCTTGGAGCTT
CTGTTACAGCTGTAAACCAAAGTGGAGCTGGTGCTTCTTGGGAGCCTCGCCTTACAACTAATTCCTGCCTTTCGTCCAGTACCAAGTCCC
CCGTTGCTTCTGGTCAGCCCACTTGTAGACTTCCAGGGGACACATCTTTATTCTGTTTCAGGAAACCAGTCACGACACGTCCACATATGT

>51075_51075_3_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000369509_length(amino acids)=570AA_BP=316
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR
FIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNV
DGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARA
LQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNV

--------------------------------------------------------------
>51075_51075_4_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000369510_length(transcript)=9293nt_BP=1685nt
AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG
AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT
CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC
CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG
GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT
ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG
GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA
ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT
CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA
CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT
TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA
AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT
GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC
CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT
GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC
AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT
ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT
GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGATATTCAAGATTAAAGCAGTGCAATTGGCT
GAGAAACTCCTTCCTGCCTTTAACACACCTACTGGGATTCCTTGGGCAATGGTGAATTTGAAAAGTATCCAGCGAGCAGCATTGGTGGTC
CTAGAAAATTACTACAAAGATTTCACCATCTATAACCCAAACCTCCTAACAGCCTCCAAATTCCGAGCAGCCAAGCATATGGCCGGGCTG
AAAGTCTACAATGTAGATGGCCCCAGTAACAATGCCACTGGCCAGTCCCGGGCCATGATTGCTGCAGCTGCTCGGCGCAGGGACTCAAGC
CACAACGAGTTGTATTATGAAGAGGCCGAACATGAACGGCGAGTAAAGAAGCGGAAAGCAAGGCTGGTGGTTGCAGTGGAAGAGGCCTTC
ATCCACATTCAGCGTCTCCAGGCTGAGGAGCAGCAGAAAGCCCCAGGGGAGGTGATGGACCCTAGGGAGGCCGCCCAGGCCATTTTCCCC
TCCATGGCCAGGGCTCTCCAGAAGTACCTGCGCATCACCCGGCAGCAGAACTACCACAGCATGGAGAGCATCCTGCAGCACCTGGCCTTC
TGCATCACCAACGGCATGACCCCCAAGGCCTTCCTAGAACGGTACCTCAGTGCGGGCCCCACCCTGCAATATGACAAGGACCGCTGGCTC
TCTACACAGTGGAGGCTTGTCAGTGATGAGGCTGTGACTAATGGATTACGGGATGGAATTGTGTTCGTCCTTAAGTGCTTGGACTTCAGC
CTCGTAGTCAATGTGAAGAAAATTCCATTCATCATACTCTCTGAAGAGTTCATAGACCCCAAATCTCACAAATTTGTCCTTCGCTTACAG
TCTGAGACATCCGTTTAAAAGTTCTATATTTGTGGCTTTATTAAAAAAAAAAGAAAAATATATAGAGAGATATATATCTATGCCAGAGGG
GTGTCTTTTTTAAAAATTCTTCTTCATTGCTGACTGAAACTGGCAGATGATTGACCAGTATCCTTTGACCATCTGCACTTTATTTGGAAG
GAAGCAGGGGCTGTCCACCCTGAAAAAGAGTGACTGATGACATCTGACTTTTGTCGATGGGACTTCTCAAGAAGCCATTCCTTGGAGCTT
CTGTTACAGCTGTAAACCAAAGTGGAGCTGGTGCTTCTTGGGAGCCTCGCCTTACAACTAATTCCTGCCTTTCGTCCAGTACCAAGTCCC
CCGTTGCTTCTGGTCAGCCCACTTGTAGACTTCCAGGGGACACATCTTTATTCTGTTTCAGGAAACCAGTCACGACACGTCCACATATGT
ATTTGTGTATGTTAATGTCCAGTATCACATCACCCATGAAAGTCGTGGGCAGTTCAGGAGATACCTGCCTTCATCTTTGTTCTTTGTTGC
CTTAGGTTCTTCAGAGAAAGATCACAACAAAAAATGTACACTGTCGTTTACAGCTATTAAGTGATTTGATTTTGTTTTTTTCCCAAAGAG
AAAACCTACCTGCCCTGTTTCTGATCCCACCCCTCTGCTGGCTTGAAGCAGGTAACCCTTTCCCAGCCCTGCAGCTGCCCACCTGGCCTC
CATGCCATCCTGCCCCCACCTGGCTGGCAGCCCTGGCTCTCCATGTGTGCCCTCCGGCTCTGTGTGAAGCCTCAAGTCAGTCCCAGCATT
GTTTCCATAGGGAAGTGTGGGGTGCCCAGCAGGTAAAGCACAGGGAGAGAGGGCAGTGGGAATGCCACCTTTAGGCTGCAGCAGGAGCCC
CACACTGCCCAGTTTTCCTCCCCACTGTTCTACACCAACCAGGGGAGACTAACACTGTGACTCTGGGATTGGCAGGTGCAACTTGGAGCC
ACTTAATTTCCTGGGGACGTAAGTTCTTCCCAAGCTTAGAGCAAGCTGCCCTGCCAAAGGAGACCAAACCATGCCAACCACGCTGGCAAC
TGCTGCTGTCCAGTCCCTGTGTTTTCTGACCACCGTCACTGTGCAACTCATCGCCTCTGCCACTTAGGACCAGGAAAGAGGCTGGTTTTG
CTCCCACTCTTAGTTGCTGATAAAGTGGGGAGAAGGAAAATGGACACTCTACAGAGTTTGGGGAAGGGAGAGTAGGGAGCCCATCTTGTC
CAGAAAGATTCATCTGTGGTCTGTCTGTTAAACACAGCTGATTTCAGTGGGCTTTCCCCTGGCCCTGGGGGAGCAGACACTGACTGGGTT
GTGGGCAGAGGAGCCATCCTGGCGGAGCCCTGCTGCAGGGGAGCTCCTTCAGGAGCCCCATCCGGACCTCTTGCACTGGGCTGCCTTTGC
CTCCATTTGCCTTCCTGTATCTGCAACAAACCTTTTAAAAGTGTTCACTCTTGCTTTTTCCAGTATTTCGGTAATCAGCCATCTTGCTGT
AGTACAGGATGACATTGTCGAATGCTCTTTGTATGTGTGCACACCCCCTTACTCCCTTACTGCTTCATACACTCCACAAGTGGTACAGTA
TTTTGTGTCATTGTAAAAATCAAAATTGGCTTTGGATCTTTGTAATACACCTGTACCTGAAAAAGTAAACAACATTCTTCAATTACTAGC
CTTCAGCTTGAAAAGACATGCTGGAGAAGAAGGAAGGGGGAACCCATAGGTGTGGCGTGGAGCCAAGATGTACTATTCAACTATGTGTTT
CTGTTTATAAAAAACACATACCATGGAACCATGGTGCTTTTGTTCTTAGTTTTTGCCGTTAGATCCCTTCAAACTGGAAGTTCCTTACAA
TATCTTTCTCAGGAAATATTTTGGGAAATGGGGTAAGAGATGGCAAGTGTGAGACGGGCTGTGTCAGAGGTTGCTACGTCATGGATACAG
TGCAGTTCCAAGTGCCATAAGTGTATGTACATATAGTTAATAATGACACTGTTCATCACCATTCTAAAATACTGTTCTTCCAACCCTATC
TTCAATGACCAGTCCAGAAGGGGTTAAGCTGGATTCATTTGCTCTGGCATGTGCATTCCCAGCAGGGTGAAGAAAGGTTTAAATTAAAGA
ATTTATTTTCTCTCTCCCCCTTCCTCTTTCTCCCAGTCTTTGCATAGGAGAATGTTAGACATTCAGAAATTACTGTTTCTGTTTTAAATT
GAGTATTGATTTTTTTATATTGACTTTGTATTGAGTTCTTTTTGAAAGAATAACAAAATAAAATGCAGGATCTTTGTAAAGCCTTTGCAC
TTTCAACCTCTTTATAGCTTGAGTTACTTTTGCAGTGGGAACAATGTAAATGACATTTAAAAGATTTAAGGTTTCAGAAAGCTGCATCCC
ACAATTGAACACAATGCATTTTTATTTCAATTCTTGGAACTGGTAGGCTATTCTTTTTAAAAGGGGGTAAACTTCGCCCTAAGGCTGGTA
GAATGTATGTTCACATTATAGTAGACAGGATTTCATTTGCCTTATATGTTTATAGATTTTTTATAATTTTCATCCTACGTTATTAAAATT
AGAGCATTGAGTGTTAAAGAACTTAATGAGGAGTCTATATCTGAGATTGCTCTCTTCCCTGGTGATGTTTTAACTGGTAGATAATTTGTT
CTTAAATATGTACTTTTGAAGATAGGACAGTTTTTATAGTCCATGAACTGAATGTTAAAAAGTTCTGTATGCATTCTCAGAGAGGATTTT
AAAGCTATATAGTTCATCCATCCTTTGCATTATCAAAATGTTAAGTCAAATCTGTAATACTTTGGCTAAAATTCATAAAGTAAGCCCTAG
AGAAAATACTTGACCACCAAATTTTTGCCCAACTATCATCACCTCCCTTCCCCCGCCTCTGTTCTTGCCTTTTGACATCTACATGGAAGA
CAAGTTCTTTACAGCAAATGGTAAGAGGCAGGTGACCTGGTGTGTTTGCTGTGTTGTAGTTCATTGCCTGGGGCTTGGGACTCCTTTTTT
AATGGAGAGACTAGCTGTGCAGGTGTGTGTTGGATAGGGATAAAGTGCTCACCCCTGCCCTCTCTACAGTAGTTGGTGGTAGATTTCTCT
CTCATTTTGCCTCATAATCACTTTCGAGTGCATGTATTTACCTAAGGGCTGTAGCTCTGTGGGATGCTACCAGCATATTGGACTGACAGA
AATTGATTACCTTGCCACTCCAACCTACGTACTGAGTGAGTGCTCCAGCCACTCAGTGAAACCAACAAAAGTGAGTCCTTGGTTTACCTT
CCAATCTGGGTCCTGCTGTGTAAGTATCCCTAAGTGGGGATGCATATTTGTTTGTGCGTTTTTATTTCCATATATGTGAGCATTTCTCTG
AGTGTATTACCAGACGGATAGCACATTTATATGTCAGACATCTTAACATCTGTGTTATCTGTAGCAGGTGTGTAGCTCAGCAGATACGTG
TCATTGTGTATATAGCTGAGTGTGTGAGGGTGTCTGTGTTTCTGCAGTCCCCTGTGTTTGAGAGATGACTTAATAACCCTGTGTTTTGAG
AGGTCGCTCTAAACCAGTGACTTTTCCCTCCCCTGCTTTATTCCTTTCCCTCACTGACACTGGCTTCTCCCGCTAGAGTAAATGGCTTTA
GCACAGCACTGTCTTCTGGGGAGCCTGCTGTCCTGCAGGCAAGTCCATTAAACTCTTTCTTGCTTTAGGACTCTGAAAACAGCAAGAAAC
AAACAAACAAAGGTCAAGCTCTAAGAAAATTACTGCTCAAACTTCACTACCCTGGAAGCCTTACTAGATATTTCTTAAGGTAACTTAAAA
ATTGGGCTTTATTTTTAAAAAGTGATAGGTTACTTACAGTAGCACAGAAATGTTAGCATATTTATTTAAATAGTCCTGCAGCAGAGACCC
TGCGATTGTAAAGTGATTTAAGTATTTCTGGGTAGTGTTTGTGATTTACGGATTTGTTACTGAAAAACAAAAAAATCACTACTGTGAATT
TACTACTATGTAACCTTGTGGTCGTATTTCATTATAAATAAAATAAGAATTGCTCTTCTGCCCACCGTTCTTGATTGGTATTCAGTGCAG
TAGCGAAATGAGATAGTTTAGACACTGTTGAAATAACTGCATTGAGCTTTAACCAAGTGTATGCTCAGAAAATTCAGTTTTGGATCACAT
TTTGACAAAACATGTTTTGGTCAAAGAAAGGAAAGGCTACTAACACATTTATCAGGTAATGTATGTCACAGTCCGTGTTCCACCCAGCCT
TGTTATCCCCACATTCTTTCAAGATAGGAGTCATCTTGGTTTTTCGGGTGAAAAACGGAAGGTCAGAGAGGAAGGGGCTTGTCCAAGGTC
TCATGTCTGGTTAACAGAATTTCAAACTAGATGTTTGATTCTAACCCCTCAGTCCACTGTACCTTGAAGTATGGTCTAAATGATTCGGCA
CTTCTGGATGTTGAGGAAGGACCTAGAGACACATCCTTGAACTAGAACCTGGGGTGAGAGTTCATTGGGAGGCAGGATCTCTTCTTTCAC
TTTGGATTTACACCTTGTCCCTTGGAAAGCTTCTCCACTATGCTAGCAAATATCTTAGGATATTTGATGGAAAGAACTTGAGAATCCCTT
CTGGAAAACCCAGCCTTTCAGTGTTAACACCTGCTGCAAGACAGGGATGCTGTTGTTCTGGCAGCCCCCCTTTGCTTTTGCCTGGCCCCA
CCTTCTGCTCCCACTCTGCTGGCTTGGGCAAGATGCGTGCCTTGGGCCTTGGGTGCAGGGAGGCAGGCAGGGGCTTGACCTGGCCTCTCT
CTGGTGCCATGGCAACATTATGCCCCAAACTTCTTCCCTGGTTGGAGTGAGAGGGGCTGTCCACAGCCCCATCCTGTGGGGATCTCAAGC
CGGAGTCCCTGGCCTGGCCTCCTTGACGTAGGTGTTCTCAGCAAGCAGTTTGCATCCCACCGTCTTTCTCACACTTGCCCCCAAGACTTT
TGACAGAGCAGACGTAAAACAGGACTCAGAAAACCATTTTTCTCTGTTCCCATATGTAGTAAGTTTTGATTCAGTTGTGCATAAACCATA
GTTTTCTGCCCTGCTGTTTGCTTTCAATGGAAGACAGTAAAGGGAAGATGGTGCTCACATCTCTCCATGTGACATCTCATTAGGAATTAA
GATGCGATGGATTAGAAATGTAAAACTTCAGAATAAAATTAAATTTCAGGGCTCTATAAGTCCCGTTTTCCCAGGTCCTGTTCCGTTTCT
ACGTAGATAACCCAATTTGTTTTGTCTATGAAATAAGCCTCTTTAGTGGGTTGTTTTAGTCTCTCCAACAAAAGAGCAGATTCCTAAAGC
CAGGTGCAGCACTGTGAAAAGTTTCTTTCAATATGGCACCAAGACTCTACCATTTATGTCTCTCTCAGCTTACAAACATCAGCGTTTTGT
CCTTGTCATAGTGGAAGAAAGACACTTACTTTAAGCTTTGGGGACAAAGGTGACAAACCCCAGGCTTTTATCTTAAAAGTGTCTTTGGCA
CTTCTTTTGGCACTGAAATGGTATTTGGGAAGCATTATTTGAATGTACAGTTGTTTGGTTTTGTATGTGCTTATCTTTATCTGAGCTTTC
ACTTGTAGACATGGCCTTTTGTTGTGAAGTTGCTCATCATTTAGGAGTGTTTAATTCTAAAAAGCCTTCAGCCTAAGAAAGCTTCATCTG
TGGGGACCAGAGACTTGTTGCTCAGGGAGTTAGTGATGGGACTTGGGCATCTGATCTGCAGGTGACAAGTTTAGTTCAACTGAAGTTGTA
GGGAATTTAGACAGTTGCACATCATTGCCGTTCTAGGGGCCTTGTAGAAAGATGAAACAGTTGTTTTTCATTTACCAGCACCTCTCAGTT
ATAGAGGTAATGGAACATTCGCTTACTTTTCATCATCATTCTTTAAAAAGGGAACATACAAAAATCTAAACTATGGCAATAATTTATTTT
TATAATAGTTTACGGTAGGCTTTAATTAAATGGCAAACTCCTCTGGGACCCCTAAGTTATGGCGTGATTAGCCAAATTTGATTTCCAACA
GTCATTTATGGCCATAACTATTGCATAGAGTGCAGGATGCCAGCAAAGATGAGGGTGGGGGCAGATACTGGCTCAGTGATTTAACTCACA
TTATAGATGACCCCTTCCTCAACAGAAATGCTACTGAGAGAACCAGAGAGGCCTGGGCCAGGCAGGTCTTATTTGAGAGGAGATTATTTG
ATAATTGCTTTGGTTAGAAGGACTTTACATTTCCTGATTTCAAGTCCAGCACCAATTTAGAAAGTTCAGAGATGAAACCACCTGTCTTTA
CCTGACAGAGTCATAACGGTTTGTGTAAAAATGTGGTCAGGGACCTTTTTTGTTCTTTCTGATTAGTTAATACTGTACATTGTAACCAGG
AGGGGCAGTTTTGCCAACCAGCCTCTGCTCATGGTCACCATATGTGTATGACAAGGCCTGAGTGAGTTCCTGCATAAACTGGGTAGTGGG
CTCTTTTGACACATTTGCAAGCATGTAAATGAATGAATGACACTACCAGCAACCATCTGTACAGGTCCATTTACTTACATTCATAAGGTT
TATGCTATGAAACTTCTTCTCATTGTGATGTCAGTAACAGAGTTAGTGTCTCTGATGGAATAGTGTACCTGTCACCCAAGTTATTTTGTT
CCTTTTTGGGTCCTCCAGTATAATCCCCCCCTCATCCCAATTAACTGTAAAATGTTTTACACATCACATTTTTTATACTGTAAACTTGGA

>51075_51075_4_MAN1A2-VANGL1_MAN1A2_chr1_117984947_ENST00000356554_VANGL1_chr1_116224985_ENST00000369510_length(amino acids)=570AA_BP=316
MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF
LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK
REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR
FIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNV
DGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARA
LQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNV

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Fusion Gene PPI Analysis for MAN1A2-VANGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAN1A2-VANGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAN1A2-VANGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource