Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAN1C1-KLC1 (FusionGDB2 ID:51082)

Fusion Gene Summary for MAN1C1-KLC1

Fusion gene summary

Fusion gene information	Fusion gene name: MAN1C1-KLC1
	Fusion gene ID: 51082
		Hgene	Tgene
	Gene symbol	MAN1C1	KLC1
	Gene ID	57134	3831
	Gene name	mannosidase alpha class 1C member 1	kinesin light chain 1
	Synonyms	HMIC\|MAN1A3\|MAN1C\|pp6318	KLC\|KNS2\|KNS2A
	Cytomap	1p36.11	14q32.33
	Type of gene	protein-coding	protein-coding
	Description	mannosyl-oligosaccharide 1,2-alpha-mannosidase IC1,2-alpha-mannosidase ICprocessing alpha-1,2-mannosidase IC	kinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50
	Modification date	20200313	20200313
	UniProtAcc	Q9NR34	Q07866
	Ensembl transtripts involved in fusion gene	ENST00000374332, ENST00000263979, ENST00000374329, ENST00000473891,	ENST00000246489, ENST00000334553, ENST00000347839, ENST00000380038, ENST00000389744, ENST00000445352, ENST00000452929, ENST00000553286, ENST00000554280, ENST00000555836, ENST00000557450, ENST00000557575, ENST00000348520,
Fusion gene scores	* DoF score	6 X 6 X 4=144	20 X 16 X 10=3200
	# samples	6	22
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/3200*10)=-3.86249647625007 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAN1C1 [Title/Abstract] AND KLC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAN1C1(25944828)-KLC1(104166992), # samples:1
Anticipated loss of major functional domain due to fusion event.	MAN1C1-KLC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAN1C1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KLC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-5410-01A	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+

Top

Fusion Gene ORF analysis for MAN1C1-KLC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000374332	ENST00000246489	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000334553	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000347839	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000380038	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000389744	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000445352	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000452929	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000553286	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000554280	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000555836	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000557450	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5CDS-intron	ENST00000374332	ENST00000557575	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-3CDS	ENST00000263979	ENST00000348520	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000246489	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000334553	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000347839	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000380038	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000389744	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000445352	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000452929	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000553286	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000554280	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000555836	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000557450	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
5UTR-intron	ENST00000263979	ENST00000557575	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
Frame-shift	ENST00000374332	ENST00000348520	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-3CDS	ENST00000374329	ENST00000348520	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-3CDS	ENST00000473891	ENST00000348520	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000246489	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000334553	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000347839	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000380038	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000389744	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000445352	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000452929	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000553286	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000554280	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000555836	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000557450	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000374329	ENST00000557575	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000246489	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000334553	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000347839	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000380038	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000389744	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000445352	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000452929	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000553286	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000554280	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000555836	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000557450	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+
intron-intron	ENST00000473891	ENST00000557575	MAN1C1	chr1	25944828	+	KLC1	chr14	104166992	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for MAN1C1-KLC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MAN1C1-KLC1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:25944828/:104166992)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAN1C1 Q9NR34	KLC1 Q07866
FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.	FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for MAN1C1-KLC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for MAN1C1-KLC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MAN1C1-KLC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MAN1C1-KLC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source