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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAN2A1-HTR4 (FusionGDB2 ID:51094)

Fusion Gene Summary for MAN2A1-HTR4

check button Fusion gene summary
Fusion gene informationFusion gene name: MAN2A1-HTR4
Fusion gene ID: 51094
HgeneTgene
Gene symbol

MAN2A1

HTR4

Gene ID

4124

3360

Gene namemannosidase alpha class 2A member 15-hydroxytryptamine receptor 4
SynonymsAMan II|GOLIM7|MANA2|MANII5-HT4|5-HT4R
Cytomap

5q21.3

5q32

Type of geneprotein-codingprotein-coding
Descriptionalpha-mannosidase 2Golgi alpha-mannosidase IIgolgi integral membrane protein 7mannosidase, alpha type IImannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase5-hydroxytryptamine receptor 45-hydroxytryptamine (serotonin) receptor 4, G protein-coupled5-hydroxytryptamine receptor 4 transcript variant b25-hydroxytryptamine receptor 4 transcript variant b3cardiac 5-HT4 receptor
Modification date2020031320200313
UniProtAcc

Q16706

.
Ensembl transtripts involved in fusion geneENST00000261483, ENST00000505313, 
ENST00000314512, ENST00000521735, 
ENST00000360693, ENST00000362016, 
ENST00000377888, ENST00000517929, 
ENST00000519495, ENST00000520086, 
ENST00000520514, ENST00000354217, 
ENST00000521530, 
Fusion gene scores* DoF score14 X 12 X 8=13444 X 4 X 3=48
# samples 144
** MAII scorelog2(14/1344*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAN2A1 [Title/Abstract] AND HTR4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAN2A1(109125228)-HTR4(147830835), # samples:2
Anticipated loss of major functional domain due to fusion event.MAN2A1-HTR4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MAN2A1-HTR4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAN2A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTR4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YU-01AMAN2A1chr5

109125228

-HTR4chr5

147830835

-
ChimerDB4SARCTCGA-DX-A6YU-01AMAN2A1chr5

109125228

+HTR4chr5

147830835

-


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Fusion Gene ORF analysis for MAN2A1-HTR4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000261483ENST00000314512MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-3UTRENST00000261483ENST00000521735MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-intronENST00000261483ENST00000360693MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-intronENST00000261483ENST00000362016MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-intronENST00000261483ENST00000377888MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-intronENST00000261483ENST00000517929MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-intronENST00000261483ENST00000519495MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-intronENST00000261483ENST00000520086MAN2A1chr5

109125228

+HTR4chr5

147830835

-
5CDS-intronENST00000261483ENST00000520514MAN2A1chr5

109125228

+HTR4chr5

147830835

-
Frame-shiftENST00000261483ENST00000354217MAN2A1chr5

109125228

+HTR4chr5

147830835

-
In-frameENST00000261483ENST00000521530MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-3CDSENST00000505313ENST00000354217MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-3CDSENST00000505313ENST00000521530MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-3UTRENST00000505313ENST00000314512MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-3UTRENST00000505313ENST00000521735MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-intronENST00000505313ENST00000360693MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-intronENST00000505313ENST00000362016MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-intronENST00000505313ENST00000377888MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-intronENST00000505313ENST00000517929MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-intronENST00000505313ENST00000519495MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-intronENST00000505313ENST00000520086MAN2A1chr5

109125228

+HTR4chr5

147830835

-
intron-intronENST00000505313ENST00000520514MAN2A1chr5

109125228

+HTR4chr5

147830835

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261483MAN2A1chr5109125228+ENST00000521530HTR4chr5147830835-323629957313082783

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261483ENST00000521530MAN2A1chr5109125228+HTR4chr5147830835-0.0018834260.9981166

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Fusion Genomic Features for MAN2A1-HTR4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAN2A1-HTR4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:109125228/chr5:147830835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN2A1

Q16706

.
FUNCTION: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN2A1chr5:109125228chr5:147830835ENST00000261483+12221_56471145.0Topological domainCytoplasmic
HgeneMAN2A1chr5:109125228chr5:147830835ENST00000261483+12226_266471145.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308117_1370429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308159_1920429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000360693081_190429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308214_2600429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308282_2940429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308316_3880429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930841_580429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930880_930429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608117_1370403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608159_1920403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000362016081_190403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608214_2600403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608282_2940403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608316_3880403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160841_580403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160880_930403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807117_1370389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807159_1920389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000377888071_190389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807214_2600389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807282_2940389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807316_3880389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880741_580389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880780_930389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906117_1370361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906159_1920361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000517929061_190361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906214_2600361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906282_2940361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906316_3880361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290641_580361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290680_930361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406117_1370412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406159_1920412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000520514061_190412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406214_2600412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406282_2940412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406316_3880412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140641_580412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140680_930412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308138_1580429.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308193_2130429.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930820_400429.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308261_2810429.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308295_3150429.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930859_790429.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930894_1160429.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608138_1580403.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608193_2130403.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160820_400403.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608261_2810403.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608295_3150403.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160859_790403.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160894_1160403.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807138_1580389.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807193_2130389.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880720_400389.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807261_2810389.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807295_3150389.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880759_790389.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880794_1160389.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906138_1580361.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906193_2130361.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290620_400361.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906261_2810361.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906295_3150361.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290659_790361.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290694_1160361.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406138_1580412.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406193_2130412.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140620_400412.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406261_2810412.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406295_3150412.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140659_790412.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140694_1160412.0TransmembraneHelical%3B Name%3D3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN2A1chr5:109125228chr5:147830835ENST00000261483+122227_11446471145.0Topological domainLumenal
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268117_137384421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268159_192384421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000314512681_19384421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268214_260384421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268282_294384421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268316_388384421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126841_58384421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126880_93384421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757117_137358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757159_192358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000354217571_19358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757214_260358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757282_294358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757316_388358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175741_58358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175780_93358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046117_137358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046159_192358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000521530461_19358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046214_260358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046282_294358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046316_388358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304641_58358388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304680_93358388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557117_137384382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557159_192384382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000521735571_19384382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557214_260384382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557282_294384382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557316_388384382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355741_58384382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355780_93384382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268138_158384421.3333333333333TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268193_213384421.3333333333333TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126820_40384421.3333333333333TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268261_281384421.3333333333333TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268295_315384421.3333333333333TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126859_79384421.3333333333333TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126894_116384421.3333333333333TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757138_158358388.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757193_213358388.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175720_40358388.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757261_281358388.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757295_315358388.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175759_79358388.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175794_116358388.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046138_158358388.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046193_213358388.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304620_40358388.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046261_281358388.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046295_315358388.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304659_79358388.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304694_116358388.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557138_158384382.3333333333333TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557193_213384382.3333333333333TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355720_40384382.3333333333333TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557261_281384382.3333333333333TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557295_315384382.3333333333333TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355759_79384382.3333333333333TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355794_116384382.3333333333333TransmembraneHelical%3B Name%3D3


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Fusion Gene Sequence for MAN2A1-HTR4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51094_51094_1_MAN2A1-HTR4_MAN2A1_chr5_109125228_ENST00000261483_HTR4_chr5_147830835_ENST00000521530_length(transcript)=3236nt_BP=2995nt
GGCGGGGCCAGCCGCCCGCTCGGCTCAGGCGCTGCGGGCGCCTATTGACCCAGCGGCTGCTGCGCCGCCGCTGTCTCCTCCTGCTCGTGG
CGGGCGGTGCTGGAGCGCCAAGTGGCGCTGGAGAACCGGCGCTTCCTTTCGCCGCTTCCGCCGCCATCTCCGCGTTTGTGGGGCGGGAAA
GAGGGAGGGGGCTAGCGGCTGCAGCTGGAGCGGGCTTCTCTCCGGGGACGGTCCTTTCCTCCCTGCTCTCCTTTTCCTTCTTTCCGCGTT
GCCGCCGCCCGCCCCCTGCGCCTCCCCGCGGAGCCTGGGTCCGGGAGGGGGAAGGTAGGGGCGGCGGGGGGCGGGAGAGTCTGGCGAGCG
GACGCTAGCTCTGAGGAAACTCATCAATCCGTGAGCCCCGGAGTCCGGGGTGCACATCGGCCCAGCCGCAGCGTCGGCGGCGGCGGCGGC
AGCAGCACGAAGGGGCTCAGTCGGGGTAGGCGGGGGCGGTGCCGGTGCCGCGGGGGCGGGCCCGACCGTCCCGCCCAGAAGTTGTAGGGC
TTGGCTCCTCGCGATCTTGTTCCTTTCCCCTCCGCTTCTCTGACCTAGCTGCGCGGCCCCGGCCCGGGAGCTGCCGAACCCGCGCCTCCC
CTGGGTGAGGAGGACACGCCTGCCCTCGTCGAGAAAACTTTTCCTGCCGACTCAGTTGGGGCGGCGGTGGCAGGAAGTGCGGGCAGCGAC
CTCTCCTCCGCCTGCCCCGCGCGCCCTGCCGGAGGTCGGCGCTGAGCTTGCGATCAAGTTTGTGGGGGCCCCCCTTCCCAGTTGCCGGCG
AGTCTCGCCTCGAGAGGGGCGCCCGACCCCGGGGAGGGCGGCAGGCCAGGGCGAAGGCCAAGGGCGTGTGGTGGCGCCGGAGACTAGGTG
CGGAGCAAGGCGGGGACTCGCACCCGCATCCGAGAGCGCGGAGGTCGCGCAGCCCGGGAGAAGGGAGCCTCCGGCGGCTGCTTCCTAGAG
TCCACAGTGCGCTGTCTCCTTTGGCTGAGGAGAGTGTCCTGGCCCCGAGTCTATCGAGGAAAATGAAGTTAAGCCGCCAGTTCACCGTGT
TCGGCAGTGCGATCTTCTGTGTGGTGATTTTCTCGCTCTACCTGATGCTGGACCGGGGTCACTTAGACTACCCCAGGAACCCGCGCCGCG
AGGGCTCCTTCCCTCAGGGCCAGCTCTCAATGTTGCAAGAAAAAATAGACCATTTGGAGCGTTTGCTAGCTGAGAATAATGAGATCATCT
CAAATATTAGAGACTCAGTCATCAATTTGAGTGAGTCTGTGGAGGATGGTCCGAAAAGTTCACAAAGCAATTTCAGCCAAGGTGCTGGCT
CACATCTTCTGCCCTCACAATTATCCCTCTCAGTTGACACTGCAGACTGTCTGTTTGCTTCACAAAGTGGAAGTCACAATTCAGATGTGC
AGATGTTGGATGTTTACAGTCTAATTTCTTTTGACAATCCAGATGGTGGAGTTTGGAAGCAAGGATTTGACATTACTTATGAATCTAATG
AATGGGACACTGAACCCCTTCAAGTCTTTGTGGTGCCTCATTCCCATAACGACCCAGGTTGGTTGAAGACTTTCAATGACTACTTTAGAG
ACAAGACTCAGTATATTTTTAATAACATGGTCCTAAAGCTGAAAGAAGACTCACGGAGGAAGTTTATTTGGTCTGAGATCTCTTACCTTT
CAAAGTGGTGGGATATTATAGATATTCAGAAGAAGGATGCTGTTAAAAGTTTAATAGAAAATGGTCAGCTTGAAATTGTGACAGGTGGCT
GGGTTATGCCTGATGAAGCTACTCCACATTATTTTGCCTTAATTGATCAACTAATTGAAGGACATCAGTGGCTGGAAAATAATATAGGAG
TGAAACCTCGGTCCGGCTGGGCTATTGATCCCTTTGGACACTCACCAACAATGGCTTATCTTCTAAACCGTGCTGGACTTTCTCACATGC
TTATCCAGAGAGTTCATTATGCAGTTAAAAAACACTTTGCACTGCATAAAACATTGGAGTTTTTTTGGAGACAGAATTGGGATCTGGGAT
CTGTCACAGATATTTTATGCCACATGATGCCCTTCTACAGCTATGACATCCCTCACACTTGTGGACCTGATCCTAAAATATGCTGCCAGT
TTGATTTTAAACGTCTTCCTGGAGGCAGATTTGGTTGTCCCTGGGGAGTCCCCCCAGAAACAATACATCCTGGAAATGTCCAAAGCAGGG
CTCGGATGCTACTAGATCAGTACCGAAAGAAGTCAAAGCTTTTTCGTACCAAAGTTCTCCTGGCTCCACTAGGAGATGATTTCCGCTACT
GTGAATACACGGAATGGGATTTACAGTTTAAGAATTATCAGCAGCTTTTTGATTATATGAATTCTCAGTCCAAGTTTAAAGTTAAGATAC
AGTTTGGAACTTTATCAGATTTTTTTGATGCGCTGGATAAAGCAGATGAAACTCAGAGAGACAAGGGCCAATCGATGTTCCCTGTTTTAA
GTGGAGATTTTTTCACTTATGCCGATCGAGATGATCATTACTGGAGTGGCTATTTTACATCCAGACCCTTTTACAAACGAATGGACAGAA
TCATGGAATCTCATTTAAGGGCTGCTGAAATTCTTTACTATTTCGCCCTGAGACAAGCTCACAAATACAAGATAAATAAATTTCTCTCAT
CATCACTTTACACGGCACTGACAGAAGCCAGAAGGAATTTGGGACTGTTTCAACATCATGATGCTATCACAGGAACTGCAAAAGACTGGG
TGGTTGTGGATTATGGTACCAGACTTTTTCATTCGTTAATGGTTTTGGAGAAGATAATTGGAAATTCTGCATTTCTTCTTATTTTGAAGG
ACAAACTCACATACGACTCTTACTCTCCTGATACCTTCCTGGAGATGGATTTGAAACAAAAATCACAAGATTCTCTGCCACAAAAAAATA
TAATAAGGCTGAGTGCGGAGCCAAGGTACACCGTTCTGCACAGGGGACATCATCAGGAACTCGAGAAACTGCCCATACACAATGACCCAG
AATCCCTGGAATCATGCTTCTGATTGAGGACATGGCTCACAACTTAGCCATTCATTCGCATTCATGTTTGCATGAACAGGTCACCCTGGC

>51094_51094_1_MAN2A1-HTR4_MAN2A1_chr5_109125228_ENST00000261483_HTR4_chr5_147830835_ENST00000521530_length(amino acids)=783AA_BP=749
MPRAPCRRSALSLRSSLWGPPFPVAGESRLERGARPRGGRQARAKAKGVWWRRRLGAEQGGDSHPHPRARRSRSPGEGSLRRLLPRVHSA
LSPLAEESVLAPSLSRKMKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIR
DSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDT
EPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMP
DEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTD
ILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYT
EWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMES
HLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLT

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Fusion Gene PPI Analysis for MAN2A1-HTR4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAN2A1-HTR4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAN2A1-HTR4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource