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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:MAP1B-SLC27A2 (FusionGDB2 ID:51152) |
Fusion Gene Summary for MAP1B-SLC27A2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MAP1B-SLC27A2 | Fusion gene ID: 51152 | Hgene | Tgene | Gene symbol | MAP1B | SLC27A2 | Gene ID | 4131 | 11001 |
Gene name | microtubule associated protein 1B | solute carrier family 27 member 2 | |
Synonyms | FUTSCH|MAP5|PPP1R102 | ACSVL1|FACVL1|FATP2|HsT17226|VLACS|VLCS|hFACVL1 | |
Cytomap | 5q13.2 | 15q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | microtubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102 | very long-chain acyl-CoA synthetaseFATP-2THCA-CoA ligasearachidonate--CoA ligasefatty acid transport protein 2fatty-acid-coenzyme A ligase, very long-chain 1long-chain-fatty-acid--CoA ligasephytanate--CoA ligasesolute carrier family 27 (fatty acid | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000504183, ENST00000296755, | ENST00000267842, ENST00000380902, ENST00000544960, | |
Fusion gene scores | * DoF score | 10 X 10 X 5=500 | 5 X 3 X 4=60 |
# samples | 13 | 5 | |
** MAII score | log2(13/500*10)=-1.94341647163363 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAP1B [Title/Abstract] AND SLC27A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | MAP1B(71411626)-SLC27A2(50489697), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP1B | GO:0009987 | cellular process | 19567321 |
Tgene | SLC27A2 | GO:0001561 | fatty acid alpha-oxidation | 10198260 |
Tgene | SLC27A2 | GO:0001676 | long-chain fatty acid metabolic process | 22022213 |
Tgene | SLC27A2 | GO:0006635 | fatty acid beta-oxidation | 10198260 |
Tgene | SLC27A2 | GO:0006699 | bile acid biosynthetic process | 11980911 |
Tgene | SLC27A2 | GO:0044539 | long-chain fatty acid import | 22022213 |
Tgene | SLC27A2 | GO:0097089 | methyl-branched fatty acid metabolic process | 10198260 |
Fusion gene breakpoints across MAP1B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across SLC27A2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | PRAD | TCGA-G9-6348-01A | MAP1B | chr5 | 71411626 | - | SLC27A2 | chr15 | 50489697 | + |
ChimerDB4 | PRAD | TCGA-G9-6348-01A | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
ChimerDB4 | PRAD | TCGA-G9-6348 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
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Fusion Gene ORF analysis for MAP1B-SLC27A2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000504183 | ENST00000267842 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
3UTR-3CDS | ENST00000504183 | ENST00000380902 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
3UTR-5UTR | ENST00000504183 | ENST00000544960 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
5CDS-5UTR | ENST00000296755 | ENST00000544960 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
In-frame | ENST00000296755 | ENST00000267842 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
In-frame | ENST00000296755 | ENST00000380902 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000296755 | MAP1B | chr5 | 71411626 | + | ENST00000267842 | SLC27A2 | chr15 | 50489697 | + | 2268 | 584 | 55 | 1968 | 637 |
ENST00000296755 | MAP1B | chr5 | 71411626 | + | ENST00000380902 | SLC27A2 | chr15 | 50489697 | + | 2092 | 584 | 55 | 1809 | 584 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000296755 | ENST00000267842 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + | 0.002086761 | 0.9979132 |
ENST00000296755 | ENST00000380902 | MAP1B | chr5 | 71411626 | + | SLC27A2 | chr15 | 50489697 | + | 0.000845381 | 0.99915457 |
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Fusion Genomic Features for MAP1B-SLC27A2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAP1B-SLC27A2 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:71411626/chr15:50489697) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 222_233 | 159 | 621.0 | Nucleotide binding | AMP | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 222_233 | 159 | 568.0 | Nucleotide binding | AMP | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 283_620 | 159 | 621.0 | Topological domain | Cytoplasmic | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 283_620 | 159 | 568.0 | Topological domain | Cytoplasmic | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 262_282 | 159 | 621.0 | Transmembrane | Helical | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 262_282 | 159 | 568.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 589_790 | 95 | 2469.0 | Compositional bias | Note=Lys-rich (highly basic%2C contains many KKEE and KKEI/V repeats) |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1878_1894 | 95 | 2469.0 | Repeat | Note=MAP1B 1 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1895_1911 | 95 | 2469.0 | Repeat | Note=MAP1B 2 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1912_1928 | 95 | 2469.0 | Repeat | Note=MAP1B 3 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1929_1945 | 95 | 2469.0 | Repeat | Note=MAP1B 4 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1946_1962 | 95 | 2469.0 | Repeat | Note=MAP1B 5 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1963_1979 | 95 | 2469.0 | Repeat | Note=MAP1B 6 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 1997_2013 | 95 | 2469.0 | Repeat | Note=MAP1B 7 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 2014_2030 | 95 | 2469.0 | Repeat | Note=MAP1B 8 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 2031_2047 | 95 | 2469.0 | Repeat | Note=MAP1B 9 |
Hgene | MAP1B | chr5:71411626 | chr15:50489697 | ENST00000296755 | + | 2 | 7 | 2048_2064 | 95 | 2469.0 | Repeat | Note=MAP1B 10 |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 128_261 | 159 | 621.0 | Topological domain | Lumenal | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 1_4 | 159 | 621.0 | Topological domain | Lumenal | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 28_106 | 159 | 621.0 | Topological domain | Cytoplasmic | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 128_261 | 159 | 568.0 | Topological domain | Lumenal | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 1_4 | 159 | 568.0 | Topological domain | Lumenal | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 28_106 | 159 | 568.0 | Topological domain | Cytoplasmic | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 107_127 | 159 | 621.0 | Transmembrane | Helical | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000267842 | 0 | 10 | 5_27 | 159 | 621.0 | Transmembrane | Helical | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 107_127 | 159 | 568.0 | Transmembrane | Helical | |
Tgene | SLC27A2 | chr5:71411626 | chr15:50489697 | ENST00000380902 | 0 | 9 | 5_27 | 159 | 568.0 | Transmembrane | Helical |
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Fusion Gene Sequence for MAP1B-SLC27A2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>51152_51152_1_MAP1B-SLC27A2_MAP1B_chr5_71411626_ENST00000296755_SLC27A2_chr15_50489697_ENST00000267842_length(transcript)=2268nt_BP=584nt GTGAGGATGTGCCGGGTGGTCCTTTCCTCCTCCTCTTCCTCCTCCTCCCGGCTCCCTGCCTAGTCTCCATATAAAAGCGGCGCCGCCTCC CCGCCCTCTCTCACTCCCCGCTCCTCTCCGCCGCGCACTCTCCGCGGCGCTGGGAGAGGGCGGAGGGGGAGGCGGCGCGCGGCGCCAGAG GAGGGGGGACGCAGGGGGCGGAGCGGAGACAGTACCTTCGGAGATAATCCTTTCTCCTGCCGCAGTGGAGAGGAGCGGCCGGAGCGAGAC ACTTCGCCGAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGC GGCGTCCACCTCGCCTAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCA CCTGCGGCGTGCCATCGGCAACATCGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACT TTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGA TGATGTGTCCATCTATTATGTGAGCAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACC TATCCCAGAGTCATGGAGGTCTGAAGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTCTTCCAAAAGCAGC CATGATCACTCATCAGCGCATATGGTATGGAACTGGCCTCACTTTTGTAAGCGGATTGAAGGCAGATGATGTCATCTATATCACTCTGCC CTTTTACCACAGTGCTGCACTACTGATTGGCATTCACGGATGTATTGTGGCTGGTGCTACTCTTGCCTTGCGGACTAAATTTTCAGCCAG CCAGTTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTATTTATGCAACTCACCACAGAA ACCAAATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACAATTTGTCAAGAGATTTGGGGA CATATGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGTTGGTGCTGTTGGAAGAGTAAA CTACCTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCGTGATGAAAATGGATATTGCGT CAGAGTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTATGCTGGAGCAAAGGCTCAGAC AGAGAAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAATGGTTGACCATGAAAATTTCAT CTATTTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGCTGATACAGTTGGACTGGTTGA TTTTGTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTCCATCAAAATGAAAGAAAACCA TGAATTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTTTCTAAGAATACAGGACACCAT TGAGATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCATCAAAGATGCCTTGTATTTCTT GGATGACACAGCAAAAATGTATGTGCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCTGAAACTCTGAATATTCCCAGG AGGATAACTCAACATTTCCAGAAAGAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGATTGAAGATTGTGAGGAAATTT TGTAGGAAATTTGCATACCCGTAAAGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAGATTTAGAGATTATTATTTTTC AGTGTGCACCTACTGTTTGTATTTGCAAACTGAGCTTGTTGGAGGGAAGGCATTATTTTTTAAAATACTTAGTAAATTAAATGAACACCA >51152_51152_1_MAP1B-SLC27A2_MAP1B_chr5_71411626_ENST00000296755_SLC27A2_chr15_50489697_ENST00000267842_length(amino acids)=637AA_BP=176 MPSLHIKAAPPPRPLSLPAPLRRALSAALGEGGGGGGARRQRRGDAGGGAETVPSEIILSPAAVERSGRSETLRRGTAAGRMATVVVEAT EPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPELQA AVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGLTFVSG LKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRG DVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLT PFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGR IGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAI -------------------------------------------------------------- >51152_51152_2_MAP1B-SLC27A2_MAP1B_chr5_71411626_ENST00000296755_SLC27A2_chr15_50489697_ENST00000380902_length(transcript)=2092nt_BP=584nt GTGAGGATGTGCCGGGTGGTCCTTTCCTCCTCCTCTTCCTCCTCCTCCCGGCTCCCTGCCTAGTCTCCATATAAAAGCGGCGCCGCCTCC CCGCCCTCTCTCACTCCCCGCTCCTCTCCGCCGCGCACTCTCCGCGGCGCTGGGAGAGGGCGGAGGGGGAGGCGGCGCGCGGCGCCAGAG GAGGGGGGACGCAGGGGGCGGAGCGGAGACAGTACCTTCGGAGATAATCCTTTCTCCTGCCGCAGTGGAGAGGAGCGGCCGGAGCGAGAC ACTTCGCCGAGGCACAGCAGCCGGCAGGATGGCGACCGTGGTGGTGGAAGCCACCGAGCCGGAGCCGTCCGGCAGCATCGCCAACCCGGC GGCGTCCACCTCGCCTAGCCTGTCGCACCGCTTCCTTGACAGCAAGTTCTACTTGCTGGTGGTCGTCGGCGAGATCGTGACCGAGGAGCA CCTGCGGCGTGCCATCGGCAACATCGAGCTCGGAATCCGATCATGGGACACAAACCTGATTGAATGCAACTTGGACCAAGAACTCAAACT TTTTGTATCTCGACACTCTGCAAGATTCTCTCCTGAAGTCCCAGAACTACAAGCAGCTGTCGAAGAGATACTGCCAAGCCTTAAAAAAGA TGATGTGTCCATCTATTATGTGAGCAGAACTTCTAACACAGATGGGATTGACTCTTTCCTGGACAAAGTGGATGAAGTATCAACTGAACC TATCCCAGAGTCATGGAGGTCTGAAGTCACTTTTTCCACTCCTGCCTTATACATTTATACTTCTGGAACCACAGGTGCTACTCTTGCCTT GCGGACTAAATTTTCAGCCAGCCAGTTTTGGGATGACTGCAGAAAATACAACGTCACTGTCATTCAGTATATCGGTGAACTGCTTCGGTA TTTATGCAACTCACCACAGAAACCAAATGACCGTGATCATAAAGTGAGACTGGCACTGGGAAATGGCTTACGAGGAGATGTGTGGAGACA ATTTGTCAAGAGATTTGGGGACATATGCATCTATGAGTTCTATGCTGCCACTGAAGGCAATATTGGATTTATGAATTATGCGAGAAAAGT TGGTGCTGTTGGAAGAGTAAACTACCTACAGAAAAAAATCATAACTTATGACCTGATTAAATATGATGTGGAGAAAGATGAACCTGTCCG TGATGAAAATGGATATTGCGTCAGAGTTCCCAAAGGTGAAGTTGGACTTCTGGTTTGCAAAATCACACAACTTACACCATTTAATGGCTA TGCTGGAGCAAAGGCTCAGACAGAGAAGAAAAAACTGAGAGATGTCTTTAAGAAAGGAGACCTCTATTTCAACAGTGGAGATCTCTTAAT GGTTGACCATGAAAATTTCATCTATTTCCACGACAGAGTTGGAGATACATTCCGGTGGAAAGGGGAAAATGTGGCCACCACTGAAGTTGC TGATACAGTTGGACTGGTTGATTTTGTCCAAGAAGTAAATGTTTATGGAGTGCATGTGCCAGATCATGAGGGTCGCATTGGCATGGCCTC CATCAAAATGAAAGAAAACCATGAATTTGATGGAAAGAAACTCTTTCAGCACATTGCTGATTACCTACCTAGTTATGCAAGGCCCCGGTT TCTAAGAATACAGGACACCATTGAGATCACTGGAACTTTTAAACACCGCAAAATGACCCTGGTGGAGGAGGGCTTTAACCCTGCTGTCAT CAAAGATGCCTTGTATTTCTTGGATGACACAGCAAAAATGTATGTGCCTATGACTGAGGACATCTATAATGCCATAAGTGCTAAAACCCT GAAACTCTGAATATTCCCAGGAGGATAACTCAACATTTCCAGAAAGAAACTGAATGGACAGCCACTTGATATAATCCAACTTTAATTTGA TTGAAGATTGTGAGGAAATTTTGTAGGAAATTTGCATACCCGTAAAGGGAGACTTTTTTAAATAACAGTTGAGTCTTTGCAAGTAAAAAG ATTTAGAGATTATTATTTTTCAGTGTGCACCTACTGTTTGTATTTGCAAACTGAGCTTGTTGGAGGGAAGGCATTATTTTTTAAAATACT >51152_51152_2_MAP1B-SLC27A2_MAP1B_chr5_71411626_ENST00000296755_SLC27A2_chr15_50489697_ENST00000380902_length(amino acids)=584AA_BP=176 MPSLHIKAAPPPRPLSLPAPLRRALSAALGEGGGGGGARRQRRGDAGGGAETVPSEIILSPAAVERSGRSETLRRGTAAGRMATVVVEAT EPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVGEIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPELQA AVEEILPSLKKDDVSIYYVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGATLALRTKFSASQFWDDCRKYNV TVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDL IKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFR WKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MAP1B-SLC27A2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAP1B-SLC27A2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAP1B-SLC27A2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |