FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:MAP2K2-INSR (FusionGDB2 ID:51187)

Fusion Gene Summary for MAP2K2-INSR

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2K2-INSR
Fusion gene ID: 51187
HgeneTgene
Gene symbol

MAP2K2

INSR

Gene ID

5605

3643

Gene namemitogen-activated protein kinase kinase 2insulin receptor
SynonymsCFC4|MAPKK2|MEK2|MKK2|PRKMK2CD220|HHF5
Cytomap

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45insulin receptorIR
Modification date2020032720200313
UniProtAcc

P36507

P06213

Ensembl transtripts involved in fusion geneENST00000599345, ENST00000394867, 
ENST00000262948, 		ENST00000302850, 
ENST00000341500, 
Fusion gene scores* DoF score10 X 6 X 6=36020 X 13 X 8=2080
# samples 1020
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2080*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP2K2 [Title/Abstract] AND INSR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP2K2(4110507)-INSR(7132328), # samples:2
Anticipated loss of major functional domain due to fusion event.MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP2K2

GO:0036289

peptidyl-serine autophosphorylation

8388392

HgeneMAP2K2

GO:0071902

positive regulation of protein serine/threonine kinase activity

8388392

TgeneINSR

GO:0001934

positive regulation of protein phosphorylation

7556070

TgeneINSR

GO:0002092

positive regulation of receptor internalization

25401701

TgeneINSR

GO:0007186

G protein-coupled receptor signaling pathway

9092559

TgeneINSR

GO:0008284

positive regulation of cell proliferation

17925406

TgeneINSR

GO:0008286

insulin receptor signaling pathway

6849137|8440175|20455999

TgeneINSR

GO:0018108

peptidyl-tyrosine phosphorylation

8496180

TgeneINSR

GO:0032148

activation of protein kinase B activity

7556070

TgeneINSR

GO:0032869

cellular response to insulin stimulus

8440175

TgeneINSR

GO:0043410

positive regulation of MAPK cascade

20455999

TgeneINSR

GO:0045725

positive regulation of glycogen biosynthetic process

17925406

TgeneINSR

GO:0046326

positive regulation of glucose import

3518947

TgeneINSR

GO:0046777

protein autophosphorylation

6849137|8496180

TgeneINSR

GO:0060267

positive regulation of respiratory burst

9092559


check buttonFusion gene breakpoints across MAP2K2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INSR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1410-01AMAP2K2chr19

4110507

-INSRchr19

7132328

-
ChimerDB4OVTCGA-13-1410MAP2K2chr19

4110506

-INSRchr19

7132328

-


Top

Fusion Gene ORF analysis for MAP2K2-INSR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000599345ENST00000302850MAP2K2chr19

4110507

-INSRchr19

7132328

-
5UTR-3CDSENST00000599345ENST00000302850MAP2K2chr19

4110506

-INSRchr19

7132328

-
5UTR-3CDSENST00000599345ENST00000341500MAP2K2chr19

4110507

-INSRchr19

7132328

-
5UTR-3CDSENST00000599345ENST00000341500MAP2K2chr19

4110506

-INSRchr19

7132328

-
Frame-shiftENST00000394867ENST00000302850MAP2K2chr19

4110507

-INSRchr19

7132328

-
Frame-shiftENST00000394867ENST00000302850MAP2K2chr19

4110506

-INSRchr19

7132328

-
Frame-shiftENST00000394867ENST00000341500MAP2K2chr19

4110507

-INSRchr19

7132328

-
Frame-shiftENST00000394867ENST00000341500MAP2K2chr19

4110506

-INSRchr19

7132328

-
In-frameENST00000262948ENST00000302850MAP2K2chr19

4110507

-INSRchr19

7132328

-
In-frameENST00000262948ENST00000302850MAP2K2chr19

4110506

-INSRchr19

7132328

-
In-frameENST00000262948ENST00000341500MAP2K2chr19

4110507

-INSRchr19

7132328

-
In-frameENST00000262948ENST00000341500MAP2K2chr19

4110506

-INSRchr19

7132328

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262948MAP2K2chr194110507-ENST00000341500INSRchr197132328-69727042542170638
ENST00000262948MAP2K2chr194110507-ENST00000302850INSRchr197132328-26007042542170638
ENST00000262948MAP2K2chr194110506-ENST00000341500INSRchr197132328-69727042542170638
ENST00000262948MAP2K2chr194110506-ENST00000302850INSRchr197132328-26007042542170638

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262948ENST00000341500MAP2K2chr194110507-INSRchr197132328-0.0008052650.9991948
ENST00000262948ENST00000302850MAP2K2chr194110507-INSRchr197132328-0.0076571130.9923429
ENST00000262948ENST00000341500MAP2K2chr194110506-INSRchr197132328-0.0008052650.9991948
ENST00000262948ENST00000302850MAP2K2chr194110506-INSRchr197132328-0.0076571130.9923429

Top

Fusion Genomic Features for MAP2K2-INSR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for MAP2K2-INSR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:4110507/chr19:7132328)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2K2

P36507

INSR

P06213

FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}.FUNCTION: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K2chr19:4110506chr19:7132328ENST00000262948-31178_86150401.0Nucleotide bindingATP
HgeneMAP2K2chr19:4110507chr19:7132328ENST00000262948-31178_86150401.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221023_12988941383.0DomainProtein kinase
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211023_12988821371.0DomainProtein kinase
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221023_12988941383.0DomainProtein kinase
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211023_12988821371.0DomainProtein kinase
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221104_11108941383.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221163_11648941383.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211104_11108821371.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211163_11648821371.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221104_11108941383.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221163_11648941383.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211104_11108821371.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211163_11648821371.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221361_13648941383.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211361_13648821371.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221361_13648941383.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211361_13648821371.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222980_13828941383.0Topological domainCytoplasmic
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121980_13828821371.0Topological domainCytoplasmic
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222980_13828941383.0Topological domainCytoplasmic
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121980_13828821371.0Topological domainCytoplasmic
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222957_9798941383.0TransmembraneHelical
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121957_9798821371.0TransmembraneHelical
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222957_9798941383.0TransmembraneHelical
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121957_9798821371.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K2chr19:4110506chr19:7132328ENST00000262948-311266_315150401.0Compositional biasNote=Pro-rich
HgeneMAP2K2chr19:4110507chr19:7132328ENST00000262948-311266_315150401.0Compositional biasNote=Pro-rich
HgeneMAP2K2chr19:4110506chr19:7132328ENST00000262948-31172_369150401.0DomainProtein kinase
HgeneMAP2K2chr19:4110507chr19:7132328ENST00000262948-31172_369150401.0DomainProtein kinase
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222182_3398941383.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110506chr19:7132328ENST00000302850122228_1748941383.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121182_3398821371.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110506chr19:7132328ENST00000341500112128_1748821371.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222182_3398941383.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110507chr19:7132328ENST00000302850122228_1748941383.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121182_3398821371.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110507chr19:7132328ENST00000341500112128_1748821371.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222624_7268941383.0DomainFibronectin type-III 1
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222757_8428941383.0DomainFibronectin type-III 2
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222853_9478941383.0DomainFibronectin type-III 3
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121624_7268821371.0DomainFibronectin type-III 1
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121757_8428821371.0DomainFibronectin type-III 2
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121853_9478821371.0DomainFibronectin type-III 3
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222624_7268941383.0DomainFibronectin type-III 1
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222757_8428941383.0DomainFibronectin type-III 2
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222853_9478941383.0DomainFibronectin type-III 3
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121624_7268821371.0DomainFibronectin type-III 1
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121757_8428821371.0DomainFibronectin type-III 2
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121853_9478821371.0DomainFibronectin type-III 3
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222733_7418941383.0RegionNote=Insulin-binding
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121733_7418821371.0RegionNote=Insulin-binding
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222733_7418941383.0RegionNote=Insulin-binding
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121733_7418821371.0RegionNote=Insulin-binding
TgeneINSRchr19:4110506chr19:7132328ENST00000302850122228_7588941383.0Topological domainExtracellular
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222763_9568941383.0Topological domainExtracellular
TgeneINSRchr19:4110506chr19:7132328ENST00000341500112128_7588821371.0Topological domainExtracellular
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121763_9568821371.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST00000302850122228_7588941383.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222763_9568941383.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST00000341500112128_7588821371.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121763_9568821371.0Topological domainExtracellular


Top

Fusion Gene Sequence for MAP2K2-INSR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51187_51187_1_MAP2K2-INSR_MAP2K2_chr19_4110506_ENST00000262948_INSR_chr19_7132328_ENST00000302850_length(transcript)=2600nt_BP=704nt
CCCCTGCCTCTCGGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGCCCCAGCGCCCCTC
GGCTACCCTCGGCCCAGGCCCGCAGCGCCGCCCGCCCTCGGCCGCCCCGACGCCGGCCTGGGCCGCGGCCGCAGCCCCGGGCTCGCGTAG
GCGCCGACCGCTCCCGGCCCGCCCCCTATGGGCCCCGGCTAGAGGCGCCGCCGCCGCCGGCCCGCGGAGCCCCGATGCTGGCCCGGAGGA
AGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTACCAGCGAGGGCGCCTCCGAGGCAAACCTGGTGG
ACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAGAAAGCCAAGGTCGGCG
AACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCC
TCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCA
ACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGAGCTGCATCTCTGCG
TCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCC
TTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCG
GCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGAC
CGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTC
GAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGG
CAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGG
GCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAG
ACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGG
CGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATG
ATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTG
TACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCA
CCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACA
ACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGC
TCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGG
AGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGG
GTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCA
ATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGG
ATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAAT
TTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAA
CCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTT

>51187_51187_1_MAP2K2-INSR_MAP2K2_chr19_4110506_ENST00000262948_INSR_chr19_7132328_ENST00000302850_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------
>51187_51187_2_MAP2K2-INSR_MAP2K2_chr19_4110506_ENST00000262948_INSR_chr19_7132328_ENST00000341500_length(transcript)=6972nt_BP=704nt
CCCCTGCCTCTCGGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGCCCCAGCGCCCCTC
GGCTACCCTCGGCCCAGGCCCGCAGCGCCGCCCGCCCTCGGCCGCCCCGACGCCGGCCTGGGCCGCGGCCGCAGCCCCGGGCTCGCGTAG
GCGCCGACCGCTCCCGGCCCGCCCCCTATGGGCCCCGGCTAGAGGCGCCGCCGCCGCCGGCCCGCGGAGCCCCGATGCTGGCCCGGAGGA
AGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTACCAGCGAGGGCGCCTCCGAGGCAAACCTGGTGG
ACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAGAAAGCCAAGGTCGGCG
AACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCC
TCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCA
ACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGAGCTGCATCTCTGCG
TCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCC
TTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCG
GCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGAC
CGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTC
GAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGG
CAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGG
GCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAG
ACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGG
CGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATG
ATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTG
TACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCA
CCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACA
ACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGC
TCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGG
AGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGG
GTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCA
ATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGG
ATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAAT
TTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAA
CCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTT
TTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACC
CAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAG
GATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTG
TGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTG
GCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTT
CTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCT
TTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTG
AGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGG
GTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTC
TTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGG
TTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCA
AGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCA
AACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTAC
GTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCC
AGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACC
TTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAG
TGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTC
TTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGT
AGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGAT
TGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACAC
GTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAA
AGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAA
ATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGA
TTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGG
GACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATAT
TCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCAT
GATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAG
CAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGG
CTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCC
AAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACC
TCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTG
TACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGA
TTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGT
TGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGC
AACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAG
CCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGT
TCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGG
ATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGAT
CTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGT
GTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTC
CTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTT
TTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTT
CAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGG
TGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTG
AGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGT
TAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCA
GGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGG
CAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGT
TTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATATGGGATAAT

>51187_51187_2_MAP2K2-INSR_MAP2K2_chr19_4110506_ENST00000262948_INSR_chr19_7132328_ENST00000341500_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------
>51187_51187_3_MAP2K2-INSR_MAP2K2_chr19_4110507_ENST00000262948_INSR_chr19_7132328_ENST00000302850_length(transcript)=2600nt_BP=704nt
CCCCTGCCTCTCGGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGCCCCAGCGCCCCTC
GGCTACCCTCGGCCCAGGCCCGCAGCGCCGCCCGCCCTCGGCCGCCCCGACGCCGGCCTGGGCCGCGGCCGCAGCCCCGGGCTCGCGTAG
GCGCCGACCGCTCCCGGCCCGCCCCCTATGGGCCCCGGCTAGAGGCGCCGCCGCCGCCGGCCCGCGGAGCCCCGATGCTGGCCCGGAGGA
AGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTACCAGCGAGGGCGCCTCCGAGGCAAACCTGGTGG
ACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAGAAAGCCAAGGTCGGCG
AACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCC
TCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCA
ACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGAGCTGCATCTCTGCG
TCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCC
TTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCG
GCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGAC
CGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTC
GAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGG
CAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGG
GCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAG
ACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGG
CGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATG
ATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTG
TACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCA
CCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACA
ACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGC
TCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGG
AGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGG
GTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCA
ATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGG
ATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAAT
TTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAA
CCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTT

>51187_51187_3_MAP2K2-INSR_MAP2K2_chr19_4110507_ENST00000262948_INSR_chr19_7132328_ENST00000302850_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------
>51187_51187_4_MAP2K2-INSR_MAP2K2_chr19_4110507_ENST00000262948_INSR_chr19_7132328_ENST00000341500_length(transcript)=6972nt_BP=704nt
CCCCTGCCTCTCGGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGCCCCAGCGCCCCTC
GGCTACCCTCGGCCCAGGCCCGCAGCGCCGCCCGCCCTCGGCCGCCCCGACGCCGGCCTGGGCCGCGGCCGCAGCCCCGGGCTCGCGTAG
GCGCCGACCGCTCCCGGCCCGCCCCCTATGGGCCCCGGCTAGAGGCGCCGCCGCCGCCGGCCCGCGGAGCCCCGATGCTGGCCCGGAGGA
AGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTACCAGCGAGGGCGCCTCCGAGGCAAACCTGGTGG
ACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAGAAAGCCAAGGTCGGCG
AACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCC
TCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCA
ACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGAGCTGCATCTCTGCG
TCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCC
TTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCG
GCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGAC
CGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTC
GAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGG
CAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGG
GCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAG
ACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGG
CGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATG
ATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTG
TACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCA
CCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACA
ACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGC
TCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGG
AGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGG
GTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCA
ATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGG
ATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAAT
TTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAA
CCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTT
TTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACC
CAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAG
GATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTG
TGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTG
GCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTT
CTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCT
TTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTG
AGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGG
GTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTC
TTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGG
TTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCA
AGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCA
AACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTAC
GTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCC
AGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACC
TTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAG
TGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTC
TTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGT
AGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGAT
TGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACAC
GTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAA
AGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAA
ATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGA
TTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGG
GACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATAT
TCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCAT
GATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAG
CAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGG
CTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCC
AAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACC
TCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTG
TACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGA
TTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGT
TGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGC
AACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAG
CCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGT
TCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGG
ATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGAT
CTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGT
GTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTC
CTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTT
TTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTT
CAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGG
TGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTG
AGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGT
TAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCA
GGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGG
CAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGT
TTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATATGGGATAAT

>51187_51187_4_MAP2K2-INSR_MAP2K2_chr19_4110507_ENST00000262948_INSR_chr19_7132328_ENST00000341500_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MAP2K2-INSR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for MAP2K2-INSR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for MAP2K2-INSR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource