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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP2K3-FAM133B (FusionGDB2 ID:51195)

Fusion Gene Summary for MAP2K3-FAM133B

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2K3-FAM133B
Fusion gene ID: 51195
HgeneTgene
Gene symbol

MAP2K3

FAM133B

Gene ID

5606

257415

Gene namemitogen-activated protein kinase kinase 3family with sequence similarity 133 member B
SynonymsMAPKK3|MEK3|MKK3|PRKMK3|SAPKK-2|SAPKK2-
Cytomap

17p11.2

7q21.2

Type of geneprotein-codingprotein-coding
Descriptiondual specificity mitogen-activated protein kinase kinase 3MAP kinase kinase 3MAPK/ERK kinase 3MAPKK 3MEK 3SAPK kinase 2stress-activated protein kinase kinase 2protein FAM133B
Modification date2020032720200313
UniProtAcc

P46734

Q5BKY9

Ensembl transtripts involved in fusion geneENST00000316920, ENST00000342679, 
ENST00000361818, ENST00000534743, 
ENST00000427372, ENST00000438306, 
ENST00000445716, 
Fusion gene scores* DoF score9 X 6 X 5=2703 X 2 X 3=18
# samples 103
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAP2K3 [Title/Abstract] AND FAM133B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP2K3(21216849)-FAM133B(92207031), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP2K3

GO:0045860

positive regulation of protein kinase activity

11980910

HgeneMAP2K3

GO:0045893

positive regulation of transcription, DNA-templated

11980910


check buttonFusion gene breakpoints across MAP2K3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM133B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BM-01AMAP2K3chr17

21216849

+FAM133Bchr7

92207031

-


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Fusion Gene ORF analysis for MAP2K3-FAM133B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000316920ENST00000427372MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000316920ENST00000438306MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000316920ENST00000445716MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000342679ENST00000427372MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000342679ENST00000438306MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000342679ENST00000445716MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000361818ENST00000427372MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000361818ENST00000438306MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
In-frameENST00000361818ENST00000445716MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
intron-3CDSENST00000534743ENST00000427372MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
intron-3CDSENST00000534743ENST00000438306MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-
intron-3CDSENST00000534743ENST00000445716MAP2K3chr17

21216849

+FAM133Bchr7

92207031

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342679MAP2K3chr1721216849+ENST00000438306FAM133Bchr792207031-313312092491643464
ENST00000342679MAP2K3chr1721216849+ENST00000445716FAM133Bchr792207031-282312092491643464
ENST00000342679MAP2K3chr1721216849+ENST00000427372FAM133Bchr792207031-164412092491643464
ENST00000361818MAP2K3chr1721216849+ENST00000438306FAM133Bchr792207031-2891967941401435
ENST00000361818MAP2K3chr1721216849+ENST00000445716FAM133Bchr792207031-2581967941401435
ENST00000361818MAP2K3chr1721216849+ENST00000427372FAM133Bchr792207031-1402967941401436
ENST00000316920MAP2K3chr1721216849+ENST00000438306FAM133Bchr792207031-30061082981516472
ENST00000316920MAP2K3chr1721216849+ENST00000445716FAM133Bchr792207031-26961082981516472
ENST00000316920MAP2K3chr1721216849+ENST00000427372FAM133Bchr792207031-15171082981516473

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342679ENST00000438306MAP2K3chr1721216849+FAM133Bchr792207031-0.0008273140.9991726
ENST00000342679ENST00000445716MAP2K3chr1721216849+FAM133Bchr792207031-0.0015510880.99844885
ENST00000342679ENST00000427372MAP2K3chr1721216849+FAM133Bchr792207031-0.0074161160.9925839
ENST00000361818ENST00000438306MAP2K3chr1721216849+FAM133Bchr792207031-0.0013974320.99860257
ENST00000361818ENST00000445716MAP2K3chr1721216849+FAM133Bchr792207031-0.0021048610.9978951
ENST00000361818ENST00000427372MAP2K3chr1721216849+FAM133Bchr792207031-0.0145070160.985493
ENST00000316920ENST00000438306MAP2K3chr1721216849+FAM133Bchr792207031-0.0014527420.99854726
ENST00000316920ENST00000445716MAP2K3chr1721216849+FAM133Bchr792207031-0.0024541940.9975458
ENST00000316920ENST00000427372MAP2K3chr1721216849+FAM133Bchr792207031-0.0108259470.989174

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Fusion Genomic Features for MAP2K3-FAM133B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP2K3-FAM133B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:21216849/chr7:92207031)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2K3

P46734

FAM133B

Q5BKY9

FUNCTION: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K3chr17:21216849chr7:92207031ENST00000316920+121370_78291319.0Nucleotide bindingATP
HgeneMAP2K3chr17:21216849chr7:92207031ENST00000342679+111270_78320348.0Nucleotide bindingATP
HgeneMAP2K3chr17:21216849chr7:92207031ENST00000361818+111270_78291319.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K3chr17:21216849chr7:92207031ENST00000316920+121364_325291319.0DomainProtein kinase
HgeneMAP2K3chr17:21216849chr7:92207031ENST00000342679+111264_325320348.0DomainProtein kinase
HgeneMAP2K3chr17:21216849chr7:92207031ENST00000361818+111264_325291319.0DomainProtein kinase
TgeneFAM133Bchr17:21216849chr7:92207031ENST0000042737241145_23893238.0Compositional biasNote=Lys-rich
TgeneFAM133Bchr17:21216849chr7:92207031ENST0000042737241182_15793238.0Compositional biasNote=Ser-rich
TgeneFAM133Bchr17:21216849chr7:92207031ENST0000043830651245_23893238.0Compositional biasNote=Lys-rich
TgeneFAM133Bchr17:21216849chr7:92207031ENST0000043830651282_15793238.0Compositional biasNote=Ser-rich
TgeneFAM133Bchr17:21216849chr7:92207031ENST0000044571641145_238103248.0Compositional biasNote=Lys-rich
TgeneFAM133Bchr17:21216849chr7:92207031ENST0000044571641182_157103248.0Compositional biasNote=Ser-rich


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Fusion Gene Sequence for MAP2K3-FAM133B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51195_51195_1_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000316920_FAM133B_chr7_92207031_ENST00000427372_length(transcript)=1517nt_BP=1082nt
GTTGGCCCGTGTGAGGAGAAGGCCGGGGCAGCGGAGGCTTCCGGCGAGAGGCTGGTCATATCCATGGTGACCATTTATGGGCCACAACAG
GTCCCCATCTGCGCAGTGAACCCTGTGCTGAGCACCTTGCAGACGTGATCTTGCTTCGTCCTGCAGCACTGTGCGGGGCAGGAAAATCCA
AGAGGAAGAAGGATCTACGGATATCCTGCATGTCCAAGCCACCCGCACCCAACCCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCA
TCACCATTGGAGACAGAAACTTTGAGGTGGAGGCTGATGACTTGGTGACCATCTCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGA
AGGTGCGGCACGCCCAGAGCGGCACCATCATGGCCGTGAAGCGGATCCGGGCCACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGG
ACCTGGACATCAACATGCGCACGGTCGACTGTTTCTACACTGTCACCTTCTACGGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCA
TGGAGCTCATGGACACATCCTTGGACAAGTTCTACCGGAAGGTGCTGGATAAAAACATGACAATTCCAGAGGACATCCTTGGGGAGATTG
CTGTGTCTATCGTGCGGGCCCTGGAGCATCTGCACAGCAAGCTGTCGGTGATCCACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACA
AGGAGGGCCATGTGAAGATGTGTGACTTTGGCATCAGTGGCTACTTGGTGGACTCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCT
ACATGGCCCCTGAGAGGATCAACCCAGAGCTGAACCAGAAGGGCTACAATGTCAAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTG
AGATGGCCATCCTGCGGTTCCCTTACGAGTCCTGGGGGACCCCGTTCCAGCAGCTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCC
CAGCCGACCGTTTCTCCCCCGAGTTTGTGGACTTCACTGCTCAGTGCCTGAGGAAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGA
TGTATTCATCTTCTTCTTCATCAAGCTCTGATTCTTCCAGCAGTTCTTCTGATTCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAA
AGAAAAAGAAGAACCGTTCACATAAATCTTCTGAAAGCTCCATGTCAGAAACTGAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGA
AGTCAAAAGATGGAACTGAGAAAGAAAAGGATATTAAAGGACTCAGCAAAAAGAGAAAGATGTATTCTGAAGATAAACCTTTATCATCTG
AGTCCTTGTCAGAATCAGAGTATATTGAGGAGGTGCGAGCAAAAAAGAAGAAAAGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAA

>51195_51195_1_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000316920_FAM133B_chr7_92207031_ENST00000427372_length(amino acids)=473AA_BP=328
MRSEPCAEHLADVILLRPAALCGAGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVR
HAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVS
IVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMA
ILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKK
KNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKK

--------------------------------------------------------------
>51195_51195_2_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000316920_FAM133B_chr7_92207031_ENST00000438306_length(transcript)=3006nt_BP=1082nt
GTTGGCCCGTGTGAGGAGAAGGCCGGGGCAGCGGAGGCTTCCGGCGAGAGGCTGGTCATATCCATGGTGACCATTTATGGGCCACAACAG
GTCCCCATCTGCGCAGTGAACCCTGTGCTGAGCACCTTGCAGACGTGATCTTGCTTCGTCCTGCAGCACTGTGCGGGGCAGGAAAATCCA
AGAGGAAGAAGGATCTACGGATATCCTGCATGTCCAAGCCACCCGCACCCAACCCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCA
TCACCATTGGAGACAGAAACTTTGAGGTGGAGGCTGATGACTTGGTGACCATCTCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGA
AGGTGCGGCACGCCCAGAGCGGCACCATCATGGCCGTGAAGCGGATCCGGGCCACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGG
ACCTGGACATCAACATGCGCACGGTCGACTGTTTCTACACTGTCACCTTCTACGGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCA
TGGAGCTCATGGACACATCCTTGGACAAGTTCTACCGGAAGGTGCTGGATAAAAACATGACAATTCCAGAGGACATCCTTGGGGAGATTG
CTGTGTCTATCGTGCGGGCCCTGGAGCATCTGCACAGCAAGCTGTCGGTGATCCACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACA
AGGAGGGCCATGTGAAGATGTGTGACTTTGGCATCAGTGGCTACTTGGTGGACTCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCT
ACATGGCCCCTGAGAGGATCAACCCAGAGCTGAACCAGAAGGGCTACAATGTCAAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTG
AGATGGCCATCCTGCGGTTCCCTTACGAGTCCTGGGGGACCCCGTTCCAGCAGCTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCC
CAGCCGACCGTTTCTCCCCCGAGTTTGTGGACTTCACTGCTCAGTGCCTGAGGAAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGA
TGTATTCATCTTCTTCTTCATCAAGCTCTGATTCTTCCAGCAGTTCTTCTGATTCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAA
AGAAAAAGAAGAACCGTTCACATAAATCTTCTGAAAGCTCCATGTCAGAAACTGAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGA
AGTCAAAAGATGGAACTGAGAAAGAAAAGGATATTAAAGGACTCAGCAAAAAGAGAAAGATGTATTCTGAAGATAAACCTTTATCATCTG
AGTCCTTGTCAGAATCAGAGTATATTGAGGAGGTGCGAGCAAAAAAGAAGAAAAGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAA
AAAAGAAAAAGAAGCATAAGAAACACAGTAAGAAGAAGAAAAAGAAGGCTGCTAGTTCAAGTCCTGACTCACCATAACATTAAGAAAAAT
CAGGATTCCCTTATAAAGAAAGTGCAATGTCTGAGGAAATTTCAACTGTGAAAACTACAACATATTTACTAAAATGCATGAATTTTCTTG
TTTTTGGAATTATTCCTGGACTATTCAGTAGCCACTCAGATGCCACTGTGTGAAAGGGCCATAAATGTTGCCTGCTGCTTGAACATCTAT
TTTTTTCTCTTCCAGTGCTTGATAACTCTGGGAGATAATACACTGCAGTCGTACTAGTGGTTAAGATATTTGGGAATAAAATTAATACTT
TTGACTAGAAGCGTCTAAGGATAAACCAACAGAAATTGAATCTGGATACATCTTTAAGATGTAATCAGAAATGACCAGATGACTCTAGTT
AGAATTTTTGAAGGAGGGATTACATTAATATTTCAAAACCCTTACTCTGTAGATAAGTGTATTTTAATTTTTTCCCCTCGTATACTTTTA
TTTACCTGGGGAAGGAGCTTTTAGGGTTGGGGGGTGGTTTGCTATCTCTTTAGCTAGCAGAATAGTGTGCCTTTGATCCTCACACATCCT
GTATTATGGACACAGTAGCCATGCTTCACGGGGAGGTCAGAGCTGGCTACCAGCAGTCTTGCCCTTTACTGAGCTTAGTGTCATCTTTGG
ATGCTGTCATATGCTGCTTTGAGTGAACCAGAGAAACAGCCATTTGCAGCATGAGAAAGCCCCAAAAGCTCTGGGATTTACCTCCACTTT
AGTAATAATGAATATTTTTTAGCATTAGAATGTGTTATGTCATTTGAATTAATTTTGACTACACTTTGGCTTGGGAGAGGAATTATTTTA
AATAGACATTGGTACTTTTTGAACTTGATAGCTAAAGATTCTAAAATGCATGTTTTATACTAAGTTTTAACCAGTCAGGAAAATTTTATG
TAACTAGTGATAGTTTATTTTTTTGTATGAATTTTGTTTAGGCTGCAATGTTTAGCTTTTGTTAACTCCTCACTCTTGCTGTCTTAAGTT
CATTACTATGTTTAATGGCCTACTTGCCAAGATATTTAGCATGTAAAAAGCAGGGTTTTGATTAAAAAAAAAAAACGGCTTCATATTGAA
GCTGAGACTTACAATAACAAGTTGAGTGGCAAGCCTGGTATGCTGTGTCTTATTGCCAGAATCTTAGTAAATGTAATGTTTTAAAAGTTT
GTTGTCTTTGTATATTAATAACAAATTATGACAAGTTAAGTTTAAATAAGAGTTACATTATTGCTCTCCCTGTGTCATATTTTACTAAGA
TTTTGTGCCTCATGTCTACTGCTGAATTGTTTACTAGGAATGTTAAAAGGAATTGATAATTCATTTTCATTTTACATTTTTATATAATCA
GGTAACATGACATACAACTTGATGTACAATTTTGCCTGTTACAAAGGGTGTGCTAATTATAGTGGTATATGCACAGAACATGTTGGCATG

>51195_51195_2_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000316920_FAM133B_chr7_92207031_ENST00000438306_length(amino acids)=472AA_BP=328
MRSEPCAEHLADVILLRPAALCGAGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVR
HAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVS
IVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMA
ILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKK
KNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKK

--------------------------------------------------------------
>51195_51195_3_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000316920_FAM133B_chr7_92207031_ENST00000445716_length(transcript)=2696nt_BP=1082nt
GTTGGCCCGTGTGAGGAGAAGGCCGGGGCAGCGGAGGCTTCCGGCGAGAGGCTGGTCATATCCATGGTGACCATTTATGGGCCACAACAG
GTCCCCATCTGCGCAGTGAACCCTGTGCTGAGCACCTTGCAGACGTGATCTTGCTTCGTCCTGCAGCACTGTGCGGGGCAGGAAAATCCA
AGAGGAAGAAGGATCTACGGATATCCTGCATGTCCAAGCCACCCGCACCCAACCCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCA
TCACCATTGGAGACAGAAACTTTGAGGTGGAGGCTGATGACTTGGTGACCATCTCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGA
AGGTGCGGCACGCCCAGAGCGGCACCATCATGGCCGTGAAGCGGATCCGGGCCACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGG
ACCTGGACATCAACATGCGCACGGTCGACTGTTTCTACACTGTCACCTTCTACGGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCA
TGGAGCTCATGGACACATCCTTGGACAAGTTCTACCGGAAGGTGCTGGATAAAAACATGACAATTCCAGAGGACATCCTTGGGGAGATTG
CTGTGTCTATCGTGCGGGCCCTGGAGCATCTGCACAGCAAGCTGTCGGTGATCCACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACA
AGGAGGGCCATGTGAAGATGTGTGACTTTGGCATCAGTGGCTACTTGGTGGACTCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCT
ACATGGCCCCTGAGAGGATCAACCCAGAGCTGAACCAGAAGGGCTACAATGTCAAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTG
AGATGGCCATCCTGCGGTTCCCTTACGAGTCCTGGGGGACCCCGTTCCAGCAGCTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCC
CAGCCGACCGTTTCTCCCCCGAGTTTGTGGACTTCACTGCTCAGTGCCTGAGGAAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGA
TGTATTCATCTTCTTCTTCATCAAGCTCTGATTCTTCCAGCAGTTCTTCTGATTCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAA
AGAAAAAGAAGAACCGTTCACATAAATCTTCTGAAAGCTCCATGTCAGAAACTGAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGA
AGTCAAAAGATGGAACTGAGAAAGAAAAGGATATTAAAGGACTCAGCAAAAAGAGAAAGATGTATTCTGAAGATAAACCTTTATCATCTG
AGTCCTTGTCAGAATCAGAGTATATTGAGGAGGTGCGAGCAAAAAAGAAGAAAAGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAA
AAAAGAAAAAGAAGCATAAGAAACACAGTAAGAAGAAGAAAAAGAAGGCTGCTAGTTCAAGTCCTGACTCACCATAACATTAAGAAAAAT
CAGGATTCCCTTATAAAGAAAGTGCAATGTCTGAGGAAATTTCAACTGTGAAAACTACAACATATTTACTAAAATGCATGAATTTTCTTG
TTTTTGGAATTATTCCTGGACTATTCAGTAGCCACTCAGATGCCACTGTGTGAAAGGGCCATAAATGTTGCCTGCTGCTTGAACATCTAT
TTTTTTCTCTTCCAGTGCTTGATAACTCTGGGAGATAATACACTGCAGTCGTACTAGTGGTTAAGATATTTGGGAATAAAATTAATACTT
TTGACTAGAAGCGTCTAAGGATAAACCAACAGAAATTGAATCTGGATACATCTTTAAGATGTAATCAGAAATGACCAGATGACTCTAGTT
AGAATTTTTGAAGGAGGGATTACATTAATATTTCAAAACCCTTACTCTGTAGATAAGTGTATTTTAATTTTTTCCCCTCGTATACTTTTA
TTTACCTGGGGAAGGAGCTTTTAGGGTTGGGGGGTGGTTTGCTATCTCTTTAGCTAGCAGAATAGTGTGCCTTTGATCCTCACACATCCT
GTATTATGGACACAGTAGCCATGCTTCACGGGGAGGTCAGAGCTGGCTACCAGCAGTCTTGCCCTTTACTGAGCTTAGTGTCATCTTTGG
ATGCTGTCATATGCTGCTTTGAGTGAACCAGAGAAACAGCCATTTGCAGCATGAGAAAGCCCCAAAAGCTCTGGGATTTACCTCCACTTT
AGTAATAATGAATATTTTTTAGCATTAGAATGTGTTATGTCATTTGAATTAATTTTGACTACACTTTGGCTTGGGAGAGGAATTATTTTA
AATAGACATTGGTACTTTTTGAACTTGATAGCTAAAGATTCTAAAATGCATGTTTTATACTAAGTTTTAACCAGTCAGGAAAATTTTATG
TAACTAGTGATAGTTTATTTTTTTGTATGAATTTTGTTTAGGCTGCAATGTTTAGCTTTTGTTAACTCCTCACTCTTGCTGTCTTAAGTT
CATTACTATGTTTAATGGCCTACTTGCCAAGATATTTAGCATGTAAAAAGCAGGGTTTTGATTAAAAAAAAAAAACGGCTTCATATTGAA

>51195_51195_3_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000316920_FAM133B_chr7_92207031_ENST00000445716_length(amino acids)=472AA_BP=328
MRSEPCAEHLADVILLRPAALCGAGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVR
HAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVS
IVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMA
ILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKK
KNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKK

--------------------------------------------------------------
>51195_51195_4_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000342679_FAM133B_chr7_92207031_ENST00000427372_length(transcript)=1644nt_BP=1209nt
AGTCAGCGCAGTTCGGCCGGGGTCTCCCCGGCGCTGCCCAGTCTGTCTCCGGCGCCGCCCGTCGCGGACTCGTCCTTGCTGCAGTCGCCG
CCGCAGTCCTCGCCGCAGTCGCCGCCGCCGCCGCCGCCGCCGCCGCTGCTCCTCCGCCTGGCCTGGGCCGTCTGCCCGCAGCCATGAGCG
TGCTCGGCCCCGGTGGAGCCCGCAGTCCTCTAGATTAGTCTCCACCGCCGTCCAGGACCCACTTGCAGCATGGAGTCGCCCGCCTCGAGC
CAGCCCGCCAGCATGCCCCAGTCCAAAGGAAAATCCAAGAGGAAGAAGGATCTACGGATATCCTGCATGTCCAAGCCACCCGCACCCAAC
CCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCATCACCATTGGAGACAGAAACTTTGAGGTGGAGGCTGATGACTTGGTGACCATC
TCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGAAGGTGCGGCACGCCCAGAGCGGCACCATCATGGCCGTGAAGCGGATCCGGGCC
ACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGGACCTGGACATCAACATGCGCACGGTCGACTGTTTCTACACTGTCACCTTCTAC
GGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCATGGAGCTCATGGACACATCCTTGGACAAGTTCTACCGGAAGGTGCTGGATAAA
AACATGACAATTCCAGAGGACATCCTTGGGGAGATTGCTGTGTCTATCGTGCGGGCCCTGGAGCATCTGCACAGCAAGCTGTCGGTGATC
CACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACAAGGAGGGCCATGTGAAGATGTGTGACTTTGGCATCAGTGGCTACTTGGTGGAC
TCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCTACATGGCCCCTGAGAGGATCAACCCAGAGCTGAACCAGAAGGGCTACAATGTC
AAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTGAGATGGCCATCCTGCGGTTCCCTTACGAGTCCTGGGGGACCCCGTTCCAGCAG
CTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCCCAGCCGACCGTTTCTCCCCCGAGTTTGTGGACTTCACTGCTCAGTGCCTGAGG
AAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGATGTATTCATCTTCTTCTTCATCAAGCTCTGATTCTTCCAGCAGTTCTTCTGAT
TCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAAAGAAAAAGAAGAACCGTTCACATAAATCTTCTGAAAGCTCCATGTCAGAAACT
GAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGAAGTCAAAAGATGGAACTGAGAAAGAAAAGGATATTAAAGGACTCAGCAAAAAG
AGAAAGATGTATTCTGAAGATAAACCTTTATCATCTGAGTCCTTGTCAGAATCAGAGTATATTGAGGAGGTGCGAGCAAAAAAGAAGAAA
AGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAAAAAAGAAAAAGAAGCATAAGAAACACAGTAAGAAGAAGAAAAAGAAGGCTGCT

>51195_51195_4_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000342679_FAM133B_chr7_92207031_ENST00000427372_length(amino acids)=464AA_BP=320
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIM
AVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYES
WGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS
ESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK

--------------------------------------------------------------
>51195_51195_5_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000342679_FAM133B_chr7_92207031_ENST00000438306_length(transcript)=3133nt_BP=1209nt
AGTCAGCGCAGTTCGGCCGGGGTCTCCCCGGCGCTGCCCAGTCTGTCTCCGGCGCCGCCCGTCGCGGACTCGTCCTTGCTGCAGTCGCCG
CCGCAGTCCTCGCCGCAGTCGCCGCCGCCGCCGCCGCCGCCGCCGCTGCTCCTCCGCCTGGCCTGGGCCGTCTGCCCGCAGCCATGAGCG
TGCTCGGCCCCGGTGGAGCCCGCAGTCCTCTAGATTAGTCTCCACCGCCGTCCAGGACCCACTTGCAGCATGGAGTCGCCCGCCTCGAGC
CAGCCCGCCAGCATGCCCCAGTCCAAAGGAAAATCCAAGAGGAAGAAGGATCTACGGATATCCTGCATGTCCAAGCCACCCGCACCCAAC
CCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCATCACCATTGGAGACAGAAACTTTGAGGTGGAGGCTGATGACTTGGTGACCATC
TCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGAAGGTGCGGCACGCCCAGAGCGGCACCATCATGGCCGTGAAGCGGATCCGGGCC
ACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGGACCTGGACATCAACATGCGCACGGTCGACTGTTTCTACACTGTCACCTTCTAC
GGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCATGGAGCTCATGGACACATCCTTGGACAAGTTCTACCGGAAGGTGCTGGATAAA
AACATGACAATTCCAGAGGACATCCTTGGGGAGATTGCTGTGTCTATCGTGCGGGCCCTGGAGCATCTGCACAGCAAGCTGTCGGTGATC
CACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACAAGGAGGGCCATGTGAAGATGTGTGACTTTGGCATCAGTGGCTACTTGGTGGAC
TCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCTACATGGCCCCTGAGAGGATCAACCCAGAGCTGAACCAGAAGGGCTACAATGTC
AAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTGAGATGGCCATCCTGCGGTTCCCTTACGAGTCCTGGGGGACCCCGTTCCAGCAG
CTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCCCAGCCGACCGTTTCTCCCCCGAGTTTGTGGACTTCACTGCTCAGTGCCTGAGG
AAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGATGTATTCATCTTCTTCTTCATCAAGCTCTGATTCTTCCAGCAGTTCTTCTGAT
TCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAAAGAAAAAGAAGAACCGTTCACATAAATCTTCTGAAAGCTCCATGTCAGAAACT
GAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGAAGTCAAAAGATGGAACTGAGAAAGAAAAGGATATTAAAGGACTCAGCAAAAAG
AGAAAGATGTATTCTGAAGATAAACCTTTATCATCTGAGTCCTTGTCAGAATCAGAGTATATTGAGGAGGTGCGAGCAAAAAAGAAGAAA
AGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAAAAAAGAAAAAGAAGCATAAGAAACACAGTAAGAAGAAGAAAAAGAAGGCTGCT
AGTTCAAGTCCTGACTCACCATAACATTAAGAAAAATCAGGATTCCCTTATAAAGAAAGTGCAATGTCTGAGGAAATTTCAACTGTGAAA
ACTACAACATATTTACTAAAATGCATGAATTTTCTTGTTTTTGGAATTATTCCTGGACTATTCAGTAGCCACTCAGATGCCACTGTGTGA
AAGGGCCATAAATGTTGCCTGCTGCTTGAACATCTATTTTTTTCTCTTCCAGTGCTTGATAACTCTGGGAGATAATACACTGCAGTCGTA
CTAGTGGTTAAGATATTTGGGAATAAAATTAATACTTTTGACTAGAAGCGTCTAAGGATAAACCAACAGAAATTGAATCTGGATACATCT
TTAAGATGTAATCAGAAATGACCAGATGACTCTAGTTAGAATTTTTGAAGGAGGGATTACATTAATATTTCAAAACCCTTACTCTGTAGA
TAAGTGTATTTTAATTTTTTCCCCTCGTATACTTTTATTTACCTGGGGAAGGAGCTTTTAGGGTTGGGGGGTGGTTTGCTATCTCTTTAG
CTAGCAGAATAGTGTGCCTTTGATCCTCACACATCCTGTATTATGGACACAGTAGCCATGCTTCACGGGGAGGTCAGAGCTGGCTACCAG
CAGTCTTGCCCTTTACTGAGCTTAGTGTCATCTTTGGATGCTGTCATATGCTGCTTTGAGTGAACCAGAGAAACAGCCATTTGCAGCATG
AGAAAGCCCCAAAAGCTCTGGGATTTACCTCCACTTTAGTAATAATGAATATTTTTTAGCATTAGAATGTGTTATGTCATTTGAATTAAT
TTTGACTACACTTTGGCTTGGGAGAGGAATTATTTTAAATAGACATTGGTACTTTTTGAACTTGATAGCTAAAGATTCTAAAATGCATGT
TTTATACTAAGTTTTAACCAGTCAGGAAAATTTTATGTAACTAGTGATAGTTTATTTTTTTGTATGAATTTTGTTTAGGCTGCAATGTTT
AGCTTTTGTTAACTCCTCACTCTTGCTGTCTTAAGTTCATTACTATGTTTAATGGCCTACTTGCCAAGATATTTAGCATGTAAAAAGCAG
GGTTTTGATTAAAAAAAAAAAACGGCTTCATATTGAAGCTGAGACTTACAATAACAAGTTGAGTGGCAAGCCTGGTATGCTGTGTCTTAT
TGCCAGAATCTTAGTAAATGTAATGTTTTAAAAGTTTGTTGTCTTTGTATATTAATAACAAATTATGACAAGTTAAGTTTAAATAAGAGT
TACATTATTGCTCTCCCTGTGTCATATTTTACTAAGATTTTGTGCCTCATGTCTACTGCTGAATTGTTTACTAGGAATGTTAAAAGGAAT
TGATAATTCATTTTCATTTTACATTTTTATATAATCAGGTAACATGACATACAACTTGATGTACAATTTTGCCTGTTACAAAGGGTGTGC

>51195_51195_5_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000342679_FAM133B_chr7_92207031_ENST00000438306_length(amino acids)=464AA_BP=320
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIM
AVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYES
WGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS
ESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK

--------------------------------------------------------------
>51195_51195_6_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000342679_FAM133B_chr7_92207031_ENST00000445716_length(transcript)=2823nt_BP=1209nt
AGTCAGCGCAGTTCGGCCGGGGTCTCCCCGGCGCTGCCCAGTCTGTCTCCGGCGCCGCCCGTCGCGGACTCGTCCTTGCTGCAGTCGCCG
CCGCAGTCCTCGCCGCAGTCGCCGCCGCCGCCGCCGCCGCCGCCGCTGCTCCTCCGCCTGGCCTGGGCCGTCTGCCCGCAGCCATGAGCG
TGCTCGGCCCCGGTGGAGCCCGCAGTCCTCTAGATTAGTCTCCACCGCCGTCCAGGACCCACTTGCAGCATGGAGTCGCCCGCCTCGAGC
CAGCCCGCCAGCATGCCCCAGTCCAAAGGAAAATCCAAGAGGAAGAAGGATCTACGGATATCCTGCATGTCCAAGCCACCCGCACCCAAC
CCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCATCACCATTGGAGACAGAAACTTTGAGGTGGAGGCTGATGACTTGGTGACCATC
TCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGAAGGTGCGGCACGCCCAGAGCGGCACCATCATGGCCGTGAAGCGGATCCGGGCC
ACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGGACCTGGACATCAACATGCGCACGGTCGACTGTTTCTACACTGTCACCTTCTAC
GGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCATGGAGCTCATGGACACATCCTTGGACAAGTTCTACCGGAAGGTGCTGGATAAA
AACATGACAATTCCAGAGGACATCCTTGGGGAGATTGCTGTGTCTATCGTGCGGGCCCTGGAGCATCTGCACAGCAAGCTGTCGGTGATC
CACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACAAGGAGGGCCATGTGAAGATGTGTGACTTTGGCATCAGTGGCTACTTGGTGGAC
TCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCTACATGGCCCCTGAGAGGATCAACCCAGAGCTGAACCAGAAGGGCTACAATGTC
AAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTGAGATGGCCATCCTGCGGTTCCCTTACGAGTCCTGGGGGACCCCGTTCCAGCAG
CTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCCCAGCCGACCGTTTCTCCCCCGAGTTTGTGGACTTCACTGCTCAGTGCCTGAGG
AAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGATGTATTCATCTTCTTCTTCATCAAGCTCTGATTCTTCCAGCAGTTCTTCTGAT
TCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAAAGAAAAAGAAGAACCGTTCACATAAATCTTCTGAAAGCTCCATGTCAGAAACT
GAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGAAGTCAAAAGATGGAACTGAGAAAGAAAAGGATATTAAAGGACTCAGCAAAAAG
AGAAAGATGTATTCTGAAGATAAACCTTTATCATCTGAGTCCTTGTCAGAATCAGAGTATATTGAGGAGGTGCGAGCAAAAAAGAAGAAA
AGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAAAAAAGAAAAAGAAGCATAAGAAACACAGTAAGAAGAAGAAAAAGAAGGCTGCT
AGTTCAAGTCCTGACTCACCATAACATTAAGAAAAATCAGGATTCCCTTATAAAGAAAGTGCAATGTCTGAGGAAATTTCAACTGTGAAA
ACTACAACATATTTACTAAAATGCATGAATTTTCTTGTTTTTGGAATTATTCCTGGACTATTCAGTAGCCACTCAGATGCCACTGTGTGA
AAGGGCCATAAATGTTGCCTGCTGCTTGAACATCTATTTTTTTCTCTTCCAGTGCTTGATAACTCTGGGAGATAATACACTGCAGTCGTA
CTAGTGGTTAAGATATTTGGGAATAAAATTAATACTTTTGACTAGAAGCGTCTAAGGATAAACCAACAGAAATTGAATCTGGATACATCT
TTAAGATGTAATCAGAAATGACCAGATGACTCTAGTTAGAATTTTTGAAGGAGGGATTACATTAATATTTCAAAACCCTTACTCTGTAGA
TAAGTGTATTTTAATTTTTTCCCCTCGTATACTTTTATTTACCTGGGGAAGGAGCTTTTAGGGTTGGGGGGTGGTTTGCTATCTCTTTAG
CTAGCAGAATAGTGTGCCTTTGATCCTCACACATCCTGTATTATGGACACAGTAGCCATGCTTCACGGGGAGGTCAGAGCTGGCTACCAG
CAGTCTTGCCCTTTACTGAGCTTAGTGTCATCTTTGGATGCTGTCATATGCTGCTTTGAGTGAACCAGAGAAACAGCCATTTGCAGCATG
AGAAAGCCCCAAAAGCTCTGGGATTTACCTCCACTTTAGTAATAATGAATATTTTTTAGCATTAGAATGTGTTATGTCATTTGAATTAAT
TTTGACTACACTTTGGCTTGGGAGAGGAATTATTTTAAATAGACATTGGTACTTTTTGAACTTGATAGCTAAAGATTCTAAAATGCATGT
TTTATACTAAGTTTTAACCAGTCAGGAAAATTTTATGTAACTAGTGATAGTTTATTTTTTTGTATGAATTTTGTTTAGGCTGCAATGTTT
AGCTTTTGTTAACTCCTCACTCTTGCTGTCTTAAGTTCATTACTATGTTTAATGGCCTACTTGCCAAGATATTTAGCATGTAAAAAGCAG
GGTTTTGATTAAAAAAAAAAAACGGCTTCATATTGAAGCTGAGACTTACAATAACAAGTTGAGTGGCAAGCCTGGTATGCTGTGTCTTAT

>51195_51195_6_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000342679_FAM133B_chr7_92207031_ENST00000445716_length(amino acids)=464AA_BP=320
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIM
AVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYES
WGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSS
ESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSK

--------------------------------------------------------------
>51195_51195_7_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000361818_FAM133B_chr7_92207031_ENST00000427372_length(transcript)=1402nt_BP=967nt
AAAGTTCTCAGTTGGCCCGTGTGAGGAGAAGGCCGGGGCAGCGGAGGCTTCCGGCGGAAAATCCAAGAGGAAGAAGGATCTACGGATATC
CTGCATGTCCAAGCCACCCGCACCCAACCCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCATCACCATTGGAGACAGAAACTTTGA
GGTGGAGGCTGATGACTTGGTGACCATCTCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGAAGGTGCGGCACGCCCAGAGCGGCAC
CATCATGGCCGTGAAGCGGATCCGGGCCACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGGACCTGGACATCAACATGCGCACGGT
CGACTGTTTCTACACTGTCACCTTCTACGGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCATGGAGCTCATGGACACATCCTTGGA
CAAGTTCTACCGGAAGGTGCTGGATAAAAACATGACAATTCCAGAGGACATCCTTGGGGAGATTGCTGTGTCTATCGTGCGGGCCCTGGA
GCATCTGCACAGCAAGCTGTCGGTGATCCACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACAAGGAGGGCCATGTGAAGATGTGTGA
CTTTGGCATCAGTGGCTACTTGGTGGACTCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCTACATGGCCCCTGAGAGGATCAACCC
AGAGCTGAACCAGAAGGGCTACAATGTCAAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTGAGATGGCCATCCTGCGGTTCCCTTA
CGAGTCCTGGGGGACCCCGTTCCAGCAGCTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCCCAGCCGACCGTTTCTCCCCCGAGTT
TGTGGACTTCACTGCTCAGTGCCTGAGGAAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGATGTATTCATCTTCTTCTTCATCAAG
CTCTGATTCTTCCAGCAGTTCTTCTGATTCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAAAGAAAAAGAAGAACCGTTCACATAA
ATCTTCTGAAAGCTCCATGTCAGAAACTGAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGAAGTCAAAAGATGGAACTGAGAAAGA
AAAGGATATTAAAGGACTCAGCAAAAAGAGAAAGATGTATTCTGAAGATAAACCTTTATCATCTGAGTCCTTGTCAGAATCAGAGTATAT
TGAGGAGGTGCGAGCAAAAAAGAAGAAAAGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAAAAAAGAAAAAGAAGCATAAGAAACA

>51195_51195_7_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000361818_FAM133B_chr7_92207031_ENST00000427372_length(amino acids)=436AA_BP=291
MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVD
CFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFV
DFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEK

--------------------------------------------------------------
>51195_51195_8_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000361818_FAM133B_chr7_92207031_ENST00000438306_length(transcript)=2891nt_BP=967nt
AAAGTTCTCAGTTGGCCCGTGTGAGGAGAAGGCCGGGGCAGCGGAGGCTTCCGGCGGAAAATCCAAGAGGAAGAAGGATCTACGGATATC
CTGCATGTCCAAGCCACCCGCACCCAACCCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCATCACCATTGGAGACAGAAACTTTGA
GGTGGAGGCTGATGACTTGGTGACCATCTCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGAAGGTGCGGCACGCCCAGAGCGGCAC
CATCATGGCCGTGAAGCGGATCCGGGCCACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGGACCTGGACATCAACATGCGCACGGT
CGACTGTTTCTACACTGTCACCTTCTACGGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCATGGAGCTCATGGACACATCCTTGGA
CAAGTTCTACCGGAAGGTGCTGGATAAAAACATGACAATTCCAGAGGACATCCTTGGGGAGATTGCTGTGTCTATCGTGCGGGCCCTGGA
GCATCTGCACAGCAAGCTGTCGGTGATCCACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACAAGGAGGGCCATGTGAAGATGTGTGA
CTTTGGCATCAGTGGCTACTTGGTGGACTCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCTACATGGCCCCTGAGAGGATCAACCC
AGAGCTGAACCAGAAGGGCTACAATGTCAAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTGAGATGGCCATCCTGCGGTTCCCTTA
CGAGTCCTGGGGGACCCCGTTCCAGCAGCTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCCCAGCCGACCGTTTCTCCCCCGAGTT
TGTGGACTTCACTGCTCAGTGCCTGAGGAAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGATGTATTCATCTTCTTCTTCATCAAG
CTCTGATTCTTCCAGCAGTTCTTCTGATTCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAAAGAAAAAGAAGAACCGTTCACATAA
ATCTTCTGAAAGCTCCATGTCAGAAACTGAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGAAGTCAAAAGATGGAACTGAGAAAGA
AAAGGATATTAAAGGACTCAGCAAAAAGAGAAAGATGTATTCTGAAGATAAACCTTTATCATCTGAGTCCTTGTCAGAATCAGAGTATAT
TGAGGAGGTGCGAGCAAAAAAGAAGAAAAGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAAAAAAGAAAAAGAAGCATAAGAAACA
CAGTAAGAAGAAGAAAAAGAAGGCTGCTAGTTCAAGTCCTGACTCACCATAACATTAAGAAAAATCAGGATTCCCTTATAAAGAAAGTGC
AATGTCTGAGGAAATTTCAACTGTGAAAACTACAACATATTTACTAAAATGCATGAATTTTCTTGTTTTTGGAATTATTCCTGGACTATT
CAGTAGCCACTCAGATGCCACTGTGTGAAAGGGCCATAAATGTTGCCTGCTGCTTGAACATCTATTTTTTTCTCTTCCAGTGCTTGATAA
CTCTGGGAGATAATACACTGCAGTCGTACTAGTGGTTAAGATATTTGGGAATAAAATTAATACTTTTGACTAGAAGCGTCTAAGGATAAA
CCAACAGAAATTGAATCTGGATACATCTTTAAGATGTAATCAGAAATGACCAGATGACTCTAGTTAGAATTTTTGAAGGAGGGATTACAT
TAATATTTCAAAACCCTTACTCTGTAGATAAGTGTATTTTAATTTTTTCCCCTCGTATACTTTTATTTACCTGGGGAAGGAGCTTTTAGG
GTTGGGGGGTGGTTTGCTATCTCTTTAGCTAGCAGAATAGTGTGCCTTTGATCCTCACACATCCTGTATTATGGACACAGTAGCCATGCT
TCACGGGGAGGTCAGAGCTGGCTACCAGCAGTCTTGCCCTTTACTGAGCTTAGTGTCATCTTTGGATGCTGTCATATGCTGCTTTGAGTG
AACCAGAGAAACAGCCATTTGCAGCATGAGAAAGCCCCAAAAGCTCTGGGATTTACCTCCACTTTAGTAATAATGAATATTTTTTAGCAT
TAGAATGTGTTATGTCATTTGAATTAATTTTGACTACACTTTGGCTTGGGAGAGGAATTATTTTAAATAGACATTGGTACTTTTTGAACT
TGATAGCTAAAGATTCTAAAATGCATGTTTTATACTAAGTTTTAACCAGTCAGGAAAATTTTATGTAACTAGTGATAGTTTATTTTTTTG
TATGAATTTTGTTTAGGCTGCAATGTTTAGCTTTTGTTAACTCCTCACTCTTGCTGTCTTAAGTTCATTACTATGTTTAATGGCCTACTT
GCCAAGATATTTAGCATGTAAAAAGCAGGGTTTTGATTAAAAAAAAAAAACGGCTTCATATTGAAGCTGAGACTTACAATAACAAGTTGA
GTGGCAAGCCTGGTATGCTGTGTCTTATTGCCAGAATCTTAGTAAATGTAATGTTTTAAAAGTTTGTTGTCTTTGTATATTAATAACAAA
TTATGACAAGTTAAGTTTAAATAAGAGTTACATTATTGCTCTCCCTGTGTCATATTTTACTAAGATTTTGTGCCTCATGTCTACTGCTGA
ATTGTTTACTAGGAATGTTAAAAGGAATTGATAATTCATTTTCATTTTACATTTTTATATAATCAGGTAACATGACATACAACTTGATGT
ACAATTTTGCCTGTTACAAAGGGTGTGCTAATTATAGTGGTATATGCACAGAACATGTTGGCATGACAACAGGCTGAATAAATAGCTATT

>51195_51195_8_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000361818_FAM133B_chr7_92207031_ENST00000438306_length(amino acids)=435AA_BP=291
MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVD
CFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFV
DFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEK

--------------------------------------------------------------
>51195_51195_9_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000361818_FAM133B_chr7_92207031_ENST00000445716_length(transcript)=2581nt_BP=967nt
AAAGTTCTCAGTTGGCCCGTGTGAGGAGAAGGCCGGGGCAGCGGAGGCTTCCGGCGGAAAATCCAAGAGGAAGAAGGATCTACGGATATC
CTGCATGTCCAAGCCACCCGCACCCAACCCCACACCCCCCCGGAACCTGGACTCCCGGACCTTCATCACCATTGGAGACAGAAACTTTGA
GGTGGAGGCTGATGACTTGGTGACCATCTCAGAACTGGGCCGTGGAGCCTATGGGGTGGTAGAGAAGGTGCGGCACGCCCAGAGCGGCAC
CATCATGGCCGTGAAGCGGATCCGGGCCACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATGGACCTGGACATCAACATGCGCACGGT
CGACTGTTTCTACACTGTCACCTTCTACGGGGCACTATTCAGAGAGGGAGACGTGTGGATCTGCATGGAGCTCATGGACACATCCTTGGA
CAAGTTCTACCGGAAGGTGCTGGATAAAAACATGACAATTCCAGAGGACATCCTTGGGGAGATTGCTGTGTCTATCGTGCGGGCCCTGGA
GCATCTGCACAGCAAGCTGTCGGTGATCCACAGAGATGTGAAGCCCTCCAATGTCCTTATCAACAAGGAGGGCCATGTGAAGATGTGTGA
CTTTGGCATCAGTGGCTACTTGGTGGACTCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCCTACATGGCCCCTGAGAGGATCAACCC
AGAGCTGAACCAGAAGGGCTACAATGTCAAGTCCGACGTCTGGAGCCTGGGCATCACCATGATTGAGATGGCCATCCTGCGGTTCCCTTA
CGAGTCCTGGGGGACCCCGTTCCAGCAGCTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTCCCAGCCGACCGTTTCTCCCCCGAGTT
TGTGGACTTCACTGCTCAGTGCCTGAGGAAGAACCCCGCAGAGCGTATGAGCTACCTGGAGCTGATGTATTCATCTTCTTCTTCATCAAG
CTCTGATTCTTCCAGCAGTTCTTCTGATTCTGAAGATGAGGATAAGAAACAAGGAAAACGGAGAAAGAAAAAGAAGAACCGTTCACATAA
ATCTTCTGAAAGCTCCATGTCAGAAACTGAATCAGACAGTAAGGATAGTTTAAAAAAGAAAAAGAAGTCAAAAGATGGAACTGAGAAAGA
AAAGGATATTAAAGGACTCAGCAAAAAGAGAAAGATGTATTCTGAAGATAAACCTTTATCATCTGAGTCCTTGTCAGAATCAGAGTATAT
TGAGGAGGTGCGAGCAAAAAAGAAGAAAAGCAGTGAAGAACGAGAAAAAGCAACAGAAAAAACAAAAAAGAAAAAGAAGCATAAGAAACA
CAGTAAGAAGAAGAAAAAGAAGGCTGCTAGTTCAAGTCCTGACTCACCATAACATTAAGAAAAATCAGGATTCCCTTATAAAGAAAGTGC
AATGTCTGAGGAAATTTCAACTGTGAAAACTACAACATATTTACTAAAATGCATGAATTTTCTTGTTTTTGGAATTATTCCTGGACTATT
CAGTAGCCACTCAGATGCCACTGTGTGAAAGGGCCATAAATGTTGCCTGCTGCTTGAACATCTATTTTTTTCTCTTCCAGTGCTTGATAA
CTCTGGGAGATAATACACTGCAGTCGTACTAGTGGTTAAGATATTTGGGAATAAAATTAATACTTTTGACTAGAAGCGTCTAAGGATAAA
CCAACAGAAATTGAATCTGGATACATCTTTAAGATGTAATCAGAAATGACCAGATGACTCTAGTTAGAATTTTTGAAGGAGGGATTACAT
TAATATTTCAAAACCCTTACTCTGTAGATAAGTGTATTTTAATTTTTTCCCCTCGTATACTTTTATTTACCTGGGGAAGGAGCTTTTAGG
GTTGGGGGGTGGTTTGCTATCTCTTTAGCTAGCAGAATAGTGTGCCTTTGATCCTCACACATCCTGTATTATGGACACAGTAGCCATGCT
TCACGGGGAGGTCAGAGCTGGCTACCAGCAGTCTTGCCCTTTACTGAGCTTAGTGTCATCTTTGGATGCTGTCATATGCTGCTTTGAGTG
AACCAGAGAAACAGCCATTTGCAGCATGAGAAAGCCCCAAAAGCTCTGGGATTTACCTCCACTTTAGTAATAATGAATATTTTTTAGCAT
TAGAATGTGTTATGTCATTTGAATTAATTTTGACTACACTTTGGCTTGGGAGAGGAATTATTTTAAATAGACATTGGTACTTTTTGAACT
TGATAGCTAAAGATTCTAAAATGCATGTTTTATACTAAGTTTTAACCAGTCAGGAAAATTTTATGTAACTAGTGATAGTTTATTTTTTTG
TATGAATTTTGTTTAGGCTGCAATGTTTAGCTTTTGTTAACTCCTCACTCTTGCTGTCTTAAGTTCATTACTATGTTTAATGGCCTACTT
GCCAAGATATTTAGCATGTAAAAAGCAGGGTTTTGATTAAAAAAAAAAAACGGCTTCATATTGAAGCTGAGACTTACAATAACAAGTTGA

>51195_51195_9_MAP2K3-FAM133B_MAP2K3_chr17_21216849_ENST00000361818_FAM133B_chr7_92207031_ENST00000445716_length(amino acids)=435AA_BP=291
MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVD
CFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDF
GISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFV
DFTAQCLRKNPAERMSYLELMYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEK

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Fusion Gene PPI Analysis for MAP2K3-FAM133B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP2K3-FAM133B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP2K3-FAM133B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource