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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP2K3-PLXDC1 (FusionGDB2 ID:51198)

Fusion Gene Summary for MAP2K3-PLXDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2K3-PLXDC1
Fusion gene ID: 51198
HgeneTgene
Gene symbol

MAP2K3

PLXDC1

Gene ID

5606

57125

Gene namemitogen-activated protein kinase kinase 3plexin domain containing 1
SynonymsMAPKK3|MEK3|MKK3|PRKMK3|SAPKK-2|SAPKK2TEM3|TEM7
Cytomap

17p11.2

17q12

Type of geneprotein-codingprotein-coding
Descriptiondual specificity mitogen-activated protein kinase kinase 3MAP kinase kinase 3MAPK/ERK kinase 3MAPKK 3MEK 3SAPK kinase 2stress-activated protein kinase kinase 2plexin domain-containing protein 12410003I07Riktumor endothelial marker 3tumor endothelial marker 7
Modification date2020032720200313
UniProtAcc

P46734

.
Ensembl transtripts involved in fusion geneENST00000534743, ENST00000342679, 
ENST00000316920, ENST00000361818, 
ENST00000315392, ENST00000394316, 
ENST00000444911, ENST00000493200, 
ENST00000539608, 
Fusion gene scores* DoF score9 X 6 X 5=27013 X 9 X 6=702
# samples 1015
** MAII scorelog2(10/270*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/702*10)=-2.22650852980868
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP2K3 [Title/Abstract] AND PLXDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP2K3(21188280)-PLXDC1(37263669), # samples:1
MAP2K3(21188280)-PLXDC1(37267247), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP2K3

GO:0045860

positive regulation of protein kinase activity

11980910

HgeneMAP2K3

GO:0045893

positive regulation of transcription, DNA-templated

11980910


check buttonFusion gene breakpoints across MAP2K3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLXDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5RZ-01AMAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
ChimerDB4BRCATCGA-OL-A5RZ-01AMAP2K3chr17

21188280

+PLXDC1chr17

37267247

+


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Fusion Gene ORF analysis for MAP2K3-PLXDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000534743ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
3UTR-5UTRENST00000534743ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
3UTR-5UTRENST00000534743ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
3UTR-5UTRENST00000534743ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
3UTR-5UTRENST00000534743ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
3UTR-intronENST00000534743ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
3UTR-intronENST00000534743ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
3UTR-intronENST00000534743ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
3UTR-intronENST00000534743ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
3UTR-intronENST00000534743ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
5CDS-5UTRENST00000342679ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
5CDS-5UTRENST00000342679ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
5CDS-5UTRENST00000342679ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
5CDS-5UTRENST00000342679ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
5CDS-intronENST00000342679ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
5CDS-intronENST00000342679ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
5CDS-intronENST00000342679ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
5CDS-intronENST00000342679ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
5CDS-intronENST00000342679ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
In-frameENST00000342679ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-3CDSENST00000316920ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-3CDSENST00000361818ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000316920ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000316920ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000316920ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000316920ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000361818ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000361818ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000361818ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-5UTRENST00000361818ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37263669

+
intron-intronENST00000316920ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000316920ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000316920ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000316920ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000316920ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000361818ENST00000315392MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000361818ENST00000394316MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000361818ENST00000444911MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000361818ENST00000493200MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+
intron-intronENST00000361818ENST00000539608MAP2K3chr17

21188280

+PLXDC1chr17

37267247

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342679MAP2K3chr1721188280+ENST00000315392PLXDC1chr1737263669+563729826962184170

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342679ENST00000315392MAP2K3chr1721188280+PLXDC1chr1737263669+0.382282640.6177174

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Fusion Genomic Features for MAP2K3-PLXDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP2K3-PLXDC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:21188280/chr17:37263669)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2K3

P46734

.
FUNCTION: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:8622669}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLXDC1chr17:21188280chr17:37263669ENST0000031539201419_4260501.0Topological domainExtracellular
TgenePLXDC1chr17:21188280chr17:37263669ENST00000315392014448_5000501.0Topological domainCytoplasmic
TgenePLXDC1chr17:21188280chr17:37263669ENST0000039431601019_4260338.0Topological domainExtracellular
TgenePLXDC1chr17:21188280chr17:37263669ENST00000394316010448_5000338.0Topological domainCytoplasmic
TgenePLXDC1chr17:21188280chr17:37263669ENST00000315392014427_4470501.0TransmembraneHelical
TgenePLXDC1chr17:21188280chr17:37263669ENST00000394316010427_4470338.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K3chr17:21188280chr17:37263669ENST00000316920+11364_3250319.0DomainProtein kinase
HgeneMAP2K3chr17:21188280chr17:37263669ENST00000342679+11264_32516348.0DomainProtein kinase
HgeneMAP2K3chr17:21188280chr17:37263669ENST00000361818+11264_3250319.0DomainProtein kinase
HgeneMAP2K3chr17:21188280chr17:37263669ENST00000316920+11370_780319.0Nucleotide bindingATP
HgeneMAP2K3chr17:21188280chr17:37263669ENST00000342679+11270_7816348.0Nucleotide bindingATP
HgeneMAP2K3chr17:21188280chr17:37263669ENST00000361818+11270_780319.0Nucleotide bindingATP


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Fusion Gene Sequence for MAP2K3-PLXDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51198_51198_1_MAP2K3-PLXDC1_MAP2K3_chr17_21188280_ENST00000342679_PLXDC1_chr17_37263669_ENST00000315392_length(transcript)=5637nt_BP=298nt
AGTCAGCGCAGTTCGGCCGGGGTCTCCCCGGCGCTGCCCAGTCTGTCTCCGGCGCCGCCCGTCGCGGACTCGTCCTTGCTGCAGTCGCCG
CCGCAGTCCTCGCCGCAGTCGCCGCCGCCGCCGCCGCCGCCGCCGCTGCTCCTCCGCCTGGCCTGGGCCGTCTGCCCGCAGCCATGAGCG
TGCTCGGCCCCGGTGGAGCCCGCAGTCCTCTAGATTAGTCTCCACCGCCGTCCAGGACCCACTTGCAGCATGGAGTCGCCCGCCTCGAGC
CAGCCCGCCAGCATGCCCCAGTCCAAAGCGTAGACCTCACCACTGGCCAGCCATGAAGTTTCGCAGCCACCCTGACCATTCCACCTATGC
GGAGGTGGAGCCCTCGGGCCATGAGAAGGAGGGCTTCATGGAGGCTGAGCAGTGCTGAGAACACCAAGTCTCCCCTTTGAAGACTTTGAG
GCCACAGAAAAGACAGTTAAAGCAAAGAAGAGAAGTGACTTTTCCTGGCCTCTCCCAGCATGCCCTGGGCTGAGATGAGATGGTGGTTTA
TGGCTCCAGAGCTGCTGCTCGCTTCGTCAGCACACCCCGAATATTGAAGAGGGGGCCAAAAAACAACCACATGGATTTTTTATAGGAACA
ACAACCTAATCTCATCCTGTTTTGATGCAAGGGTTCTCTTCTGTGTCTTGTAACCATGAAACAGCAGAAGAACTAACATAACTAACTCCA
TTTTTGTTTAAGGGGCCTTTACCTATTCCTGCACCTAGGCTAGGATAACTTTAGAGCACTGACATAAAACGCAAAAACAGGAATCATGCC
GTTTGCAAAACTAACTCTGGGATTAAAGGGGAAGCATGTAAACAGCTAACTGTTTTTGTTAAAGATTTATAGGAATGAGGAGGTTTGGCT
ATTGTCACATGACAGACTGTTAGCCAAGGACAAAGAAGTTCTGCAAACCTCCCCTGGACCCTTGCTGGTGTCCAGATGTCTGCGGTTGTC
AGCCCCTTCCTTTCCCCCGACCTAAACATAAAAGACAAGGCAAAGCCCGCATAATTTTAAGACGGTTCTTTAGGACATTAGTCCACCATC
TTCTTGGTTTGCTGGCTCTCCGAAATAAAGTCCCTTTCCTTGCTCCAACTCCTTGTCTCTCAACGTATTGGCTATGACGCAGCAAGCAGA
ATGAATTTGGACTCAGTTACAGGCTGTCAATGGTCTGCTCTGTAGCAGTCTCAGAGCCTCCCCGACCCACTACCTGGAGATAGCCAGATA
GCCAGATGCCCTGCTCCTGGCCACCTTTAAAGCCCCTGCATATGACACAGGTTAACTAAAGTCAAGATTGGGGCTGCTGCATTCCAGGTT
CCCTAGACTCACAAGCTGGTCCTTGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACCT
GAAGTCAGAAGTTTGAGACCAGCCTGGCCAACATAATTAAAATGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGACGCTTGC
CTGTATCCCAGCTACTCAGGAAGCTGAGACACGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCTCAGATAGTGCCACTGCA
CTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAGAAAGCAGATCCTCATGGCTATAGAGTTGGCATTTTAGCCCCA
GCTTCTGTAGCTCTGAAAGCCTAAAGAAGGTATTCTCTCCATCTGTTAAACACAGTATAGTGGCTCTCAGCCCTTGGGGCATGTTATCAT
GGGAGGGAAGTCAAATAAGAGGAGAGAAAAGAACTCAAGGGGGAAACTGCATTTTTAGGCTTTGCTCTCTTACCTTGCCCTTTCTACTCA
GAACCAATAACTTCTGCATCAAAACATGTTACAGCCTGCATCAAGGGCTTTACCCCAACCTGCAGCCCAGCCTTCCCTGGGTGAGCTTGC
TATGCGCAGCCACATTTACCATGTGGGGCTCCCTATTCTGATGGCCTGTTCGGTGCCGGGTTTACTCACTGCCCTGTTCTGATGTCAGTG
CCTGTACATACCTCCAAAGGCAGGACTTGCCTGATAAATATTTTTCCTCCTCTGAACTGGATTTTATAGGCATTAAAGACAAGTCGGGTG
GCTAGAGGGCTCCTTGAGACATACCTAGCAGGGAACTGCAGGTGGATTCTGTTGAGAGGCAAAGCACCTGAGTGGTTGGGACACAGGCAG
CTGGCATGGGAGGGACTTTTTTTGAGACAGGGTCTCACTGTGTCGCCCAGGGCAAGGATGCCCAAAGACACCAGGTTGGAGAGGCACCTG
CCAACTACTTGCTTTCCCTGGAGCCTGCATGTGCCTGTGGGGTGGGGAGGCGTAGGGGTCTACGGCTGCCTGAGATGGGTGTGCACAGTG
TGTGAAGTACCTACCTCCTTGCCTTGCTGGACTGTCAGCCAGTCGCAGGGCCGGCCACAAGACCCATGTCTCCATCTGGTCATACTCCAT
AGCTACCAAGTTAACCTGCTCTAAACTTTGGAGAACTGGATCTGTCCAATAAACGCTTATTTGGCCAAGCCTGATGGCTCGTGCCTGTAC
TCCCAGCACTTTGGGAGGCTGAGGTGGGAGGGTTGCTTGAGCCCAGGGGTTTGAGACCAGCTTGGGCAACAACAACAAAAATGCCAGGTG
TGGTGGGGTGCACCTGTAGTCCCAGCTACTAGGGAGGCTGAGCCAGGAGGATCACTTGAGCCCGGGAGGTTGAGGCTGCAGTGGGGGGTC
ATAATCATGCCACTGTACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTCCGAAAAAAAAAAAAAAAAAAAGAACGGAAAAAGAAATGC
TTACATTGTCAGGGATCCTGTAGACAATCATTAACTCTATGAGATGCTTGGTTCTATTTTTTTGGGAGACTTTGTCCAAGTGTTTTGGCT
TAAGAAATCCATAGGCCTCTCTTGGTGACACATCTCTAGTACTTTTTGTCATAAACAAACAGGCCATCTGCCGCCAAATACATCCACTCC
CCATGCCACTGACATCCTATGGGTCAGCCAGGCTTGCTTTGACTGAGGCCGAGGCATCTGGAACTTTCTCTGCCTGCAGGGGCTAGCAGC
AGAGGCTTCACCGCATCACCACCCCTTCCTCCACTCCTGACATTCTTTCCCTTCAGGGATCCAAAATGGTTGGCCGAGCTCCCAGTGGGA
AAACGTGTGCTAGAGTTGGGGAGTGAGATGAGTGGTGCTGTCCATGGAATCAGGCCACAGCAGGAACTGCCCCACTGGCCATTTGAGACA
CACACAGGTGGTAAATGCTCTGCTGGTGGGCTGTGCTTCCCTCATTCAGAGAGCTCTGTTACAGCCCACTGTGTCCTTTAGAAGCTTGAA
AGGAACCCAACTCTTTGCTGCACTGTCCTTTTTCTTCCTCAAATTCAGACCCTCCTTCCACCGGCACCCCCCTACTCCACCCTCAGCTCT
TCCTTGCCTGGTTTATCAAGCAGAGCTGAGGCCCCACGTTTCCAACTCTGATTGTCACTTGCATCTTCACAAAGGATAAACCACGGAGCA
ACTGGAAAACCATCAGCCAAGCGTTCGGATGAGTCTGGTTATTGGTCCACCCCCGACCAGATTCCCTTACACTTAACTCACTTCTTTCTT
TGGCAATGACCCTCATGACATGTATAAATGGGTATGACTAAGAAGAGGCTGTGATCTAACATTTATTTGCTGCCATTTTTTACTCTGGGG
AGAAGCAGCCCCAACTCATCACTGGGAAAGAACTCCCCCTGCAAACCAGCTAAATTTGATAATTTAAACCCCCTGCCCCTAAAACTTCTC
ACAGAGCTGGGGAGTTGGTGGCAACTTTCCAAGTCAAGGTCTTGCTTAGAAAGTCCTTCACTACATGGCCAGGTGCAGTGGCTCACGCCT
GTAGTCCCAGGTACTTGGGAGCCTGAGGCAGGAGGATTGCTTGAGCTCAGGAGTTCAAGGCTGCAGAGAGCTATGATCATCCCACTGCAT
TTGTTTAAAAATAAATTTTTAAAATTTGTGTGTTTTATCAGGGGTCTCCTGTACAGTGTATCTGTGTATGTTTGTGTGTGTGTTTGTATA
CAGCCTTGTTTAATGTTTTGAGCAATAAGATATGCACACACAGGTATTTTGTTGCTAAAGAGATTGGACAAGGTTGTAGCTGTGCTCAGG
CTTCAGCTTGGTTTGTTAAATTGAGAGATAAACAATGACAAGAGCTGCCAGCCAACCACACTATTCAAAAAGCAAAGTGTTCACCACTAA
AGCTAACCATTCATCTGGTTGCAGGCAAGGCTAAGGCTCTCTCTCCTCTAGTTCCTGGAACAGACTCACAGATTGGCATGAAGCACTGAT
CAGGGGCTGCACTCAGACTCCCTGGCCAAGCAAACCTACACCAGAAGAGTCAGTGTCACAGATATGATGCGGCCAATCTCTGTCTCCAAA
AACCTACCTGAACTTAATGGTAGAATTCAAAGATCTGGGGACTGAGGGCACCCAGCCTTCTAAAACACAATGTATTCATGTGTTTAGTGT
AAACTCTCTGCATGGATTCTCAGTGTTAATAATAAAAGGAAGCATTCTTTTACAACTCCTGCTGTGTGCAAAAGAAAGTGCAAAGGATTT
GGAGTGGCATTCCGAAGATCACCACACATACCTTGGTTCTGATGGCTGCTGAACTCCGACTTCTTCGCTGAGACATGACTGTGGGAACAG
CCTCCAGCTATCTGCTCATCAGAGGTGCTTTCCTCAACCTCCTGCACCACCTCCAAGAGAAACAGCCTAAAAAGAAACCCCAGCTGTTTA
CTTATATTGGTCTGTAAATCCCTGGAAGTAAACCCCATGCATTTTTATCTACTGTCTGAGGACATACAATAAATCTGAGAAAGTCTATGC
TGTCAGCCTTCAGAACAACCTGTCCCCCAAGACAAAGGGCACTCCTGTGCACCTGGGCACCATCGTGGGCATCGTGCTGGCAGTCCTCCT
CGTGGCGGCCATCATCCTGGCTGGAATTTACATCAATGGCCACCCCACATCCAATGCTGCGCTCTTCTTCATCGAGATGACACCAAGTTG
AATCCCTATGCAGGAGGAGACGGCAGAGGGCAGGATGTGCGAGGACTTCCAGGATGAGGACCACGACTCAGCCTCCCCTGACACTTCCTT
CAGCCCCTATGATGGAGACCTCACCACTACCTCCTCCTCCCTCTTCATCGACAGCCTCACCACAGAAGATGCTCCAGTGGCTTTGACCGC
TATCGCCAGGAGTGGATGGACTATGGCTGTGCACAGGAGCCTGCCTGCAGCATAGGAGCTGTGACGCCTGCATGTCCTCAGACCTGACCT
TCAACTGCAGCTGGTGCCATGTCCTCCAGAGAATCTCGGCGAAGGAGCATCTTTGAATATCACCGCATAGAGCTGGACCCCAGCAAGGTC
ACCAGCATGTCGGCCGTGGAGTTCACCCCATTGCCGAATCCCTATGTCTGTCCCGGAAATCAGCTCCTCCCAGCATCCTGTCAAAACCGG

>51198_51198_1_MAP2K3-PLXDC1_MAP2K3_chr17_21188280_ENST00000342679_PLXDC1_chr17_37263669_ENST00000315392_length(amino acids)=170AA_BP=6
MAFLLLLPKLVSNPWAQATLPPQPPKVLGVQARAIRLGQISVYWTDPVLQSLEQVNLVAMEYDQMETWVLWPALRLADSPARQGGRYFTH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAP2K3-PLXDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP2K3-PLXDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP2K3-PLXDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource