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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP2K4-DNAH9 (FusionGDB2 ID:51207)

Fusion Gene Summary for MAP2K4-DNAH9

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2K4-DNAH9
Fusion gene ID: 51207
HgeneTgene
Gene symbol

MAP2K4

DNAH9

Gene ID

6416

1770

Gene namemitogen-activated protein kinase kinase 4dynein axonemal heavy chain 9
SynonymsJNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1CILD40|DNAH17L|DNEL1|DYH9|Dnahc9|HL-20|HL20
Cytomap

17p12

17p12

Type of geneprotein-codingprotein-coding
Descriptiondual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1dynein heavy chain 9, axonemalDNAH9 variant proteinaxonemal beta dynein heavy chain 9ciliary dynein heavy chain 9dynein, axonemal, heavy polypeptide 9
Modification date2020032920200327
UniProtAcc

P45985

Q9NYC9

Ensembl transtripts involved in fusion geneENST00000353533, ENST00000415385, 
ENST00000581941, 		ENST00000396001, 
ENST00000579828, ENST00000262442, 
ENST00000454412, ENST00000608377, 
Fusion gene scores* DoF score10 X 4 X 7=2804 X 6 X 4=96
# samples 136
** MAII scorelog2(13/280*10)=-1.10691520391651
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP2K4 [Title/Abstract] AND DNAH9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP2K4(12032604)-DNAH9(11865184), # samples:2
Anticipated loss of major functional domain due to fusion event.MAP2K4-DNAH9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MAP2K4-DNAH9 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP2K4-DNAH9 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MAP2K4-DNAH9 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAP2K4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNAH9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A109-01AMAP2K4chr17

12032604

-DNAH9chr17

11865184

+
ChimerDB4BRCATCGA-E2-A109-01AMAP2K4chr17

12032604

+DNAH9chr17

11865184

+
ChimerDB4ESCATCGA-L5-A8NV-01AMAP2K4chr17

11924318

+DNAH9chr17

11827131

+
ChimerDB4ESCATCGA-L5-A8NVMAP2K4chr17

11924318

+DNAH9chr17

11827130

+


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Fusion Gene ORF analysis for MAP2K4-DNAH9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000353533ENST00000396001MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
5CDS-3UTRENST00000353533ENST00000396001MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
5CDS-3UTRENST00000353533ENST00000396001MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
5CDS-3UTRENST00000415385ENST00000396001MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
5CDS-3UTRENST00000415385ENST00000396001MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
5CDS-3UTRENST00000415385ENST00000396001MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
5CDS-intronENST00000353533ENST00000579828MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
5CDS-intronENST00000353533ENST00000579828MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
5CDS-intronENST00000353533ENST00000579828MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
5CDS-intronENST00000415385ENST00000579828MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
5CDS-intronENST00000415385ENST00000579828MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
5CDS-intronENST00000415385ENST00000579828MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
Frame-shiftENST00000353533ENST00000262442MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
Frame-shiftENST00000353533ENST00000454412MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
Frame-shiftENST00000353533ENST00000608377MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
Frame-shiftENST00000415385ENST00000262442MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
Frame-shiftENST00000415385ENST00000454412MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
Frame-shiftENST00000415385ENST00000608377MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
In-frameENST00000353533ENST00000262442MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
In-frameENST00000353533ENST00000262442MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
In-frameENST00000353533ENST00000454412MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
In-frameENST00000353533ENST00000454412MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
In-frameENST00000353533ENST00000608377MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
In-frameENST00000353533ENST00000608377MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
In-frameENST00000415385ENST00000262442MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
In-frameENST00000415385ENST00000262442MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
In-frameENST00000415385ENST00000454412MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
In-frameENST00000415385ENST00000454412MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
In-frameENST00000415385ENST00000608377MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
In-frameENST00000415385ENST00000608377MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
intron-3CDSENST00000581941ENST00000262442MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
intron-3CDSENST00000581941ENST00000262442MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
intron-3CDSENST00000581941ENST00000262442MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
intron-3CDSENST00000581941ENST00000454412MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
intron-3CDSENST00000581941ENST00000454412MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
intron-3CDSENST00000581941ENST00000454412MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
intron-3CDSENST00000581941ENST00000608377MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
intron-3CDSENST00000581941ENST00000608377MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
intron-3CDSENST00000581941ENST00000608377MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
intron-3UTRENST00000581941ENST00000396001MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
intron-3UTRENST00000581941ENST00000396001MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
intron-3UTRENST00000581941ENST00000396001MAP2K4chr17

11924318

+DNAH9chr17

11827130

+
intron-intronENST00000581941ENST00000579828MAP2K4chr17

12032604

+DNAH9chr17

11865184

+
intron-intronENST00000581941ENST00000579828MAP2K4chr17

11924318

+DNAH9chr17

11827131

+
intron-intronENST00000581941ENST00000579828MAP2K4chr17

11924318

+DNAH9chr17

11827130

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAP2K4-DNAH9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAP2K4-DNAH9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:12032604/chr17:11865184)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2K4

P45985

DNAH9

Q9NYC9

FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}.FUNCTION: Force generating protein required for cilia beating in respiratory epithelia (PubMed:30471717, PubMed:30471718). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. {ECO:0000269|PubMed:30471717, ECO:0000269|PubMed:30471718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000353533+1115_1938400.0Compositional biasNote=Gly/Ser-rich
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000415385+1125_1938411.0Compositional biasNote=Gly/Ser-rich
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000353533+1115_1938400.0Compositional biasNote=Gly/Ser-rich
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000415385+1125_1938411.0Compositional biasNote=Gly/Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000353533+111102_36738400.0DomainProtein kinase
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000415385+112102_36738411.0DomainProtein kinase
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000353533+111102_36738400.0DomainProtein kinase
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000415385+112102_36738411.0DomainProtein kinase
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000353533+111108_11638400.0Nucleotide bindingATP
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000415385+112108_11638411.0Nucleotide bindingATP
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000353533+111108_11638400.0Nucleotide bindingATP
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000415385+112108_11638411.0Nucleotide bindingATP
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000353533+111364_38738400.0RegionNote=DVD domain
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000353533+11137_5238400.0RegionNote=D domain
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000415385+112364_38738411.0RegionNote=DVD domain
HgeneMAP2K4chr17:11924318chr17:11827130ENST00000415385+11237_5238411.0RegionNote=D domain
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000353533+111364_38738400.0RegionNote=DVD domain
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000353533+11137_5238400.0RegionNote=D domain
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000415385+112364_38738411.0RegionNote=DVD domain
HgeneMAP2K4chr17:11924318chr17:11827131ENST00000415385+11237_5238411.0RegionNote=D domain
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260691326_135539164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260693051_315439164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260693285_334139164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260693640_367539164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST000002624426069381_41039164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST000002624426069504_52939164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST000002624426069639_66239164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST000002624426069752_82339164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260691326_135539164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260693051_315439164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260693285_334139164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260693640_367539164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST000002624426069381_41039164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST000002624426069504_52939164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST000002624426069639_66239164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827131ENST000002624426069752_82339164487.0Coiled coilOntology_term=ECO:0000255
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260691870_187739164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260692151_215839164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260692478_248539164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260692825_283239164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260691870_187739164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260692151_215839164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260692478_248539164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260692825_283239164487.0Nucleotide bindingATP
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260691832_205339164487.0RegionAAA 1
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260691_183139164487.0RegionStem
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260692113_233439164487.0RegionAAA 2
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260692440_268839164487.0RegionAAA 3
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260692787_303639164487.0RegionAAA 4
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260693051_334139164487.0RegionStalk
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260693429_365639164487.0RegionAAA 5
TgeneDNAH9chr17:11924318chr17:11827130ENST0000026244260693866_409239164487.0RegionAAA 6
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260691832_205339164487.0RegionAAA 1
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260691_183139164487.0RegionStem
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260692113_233439164487.0RegionAAA 2
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260692440_268839164487.0RegionAAA 3
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260692787_303639164487.0RegionAAA 4
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260693051_334139164487.0RegionStalk
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260693429_365639164487.0RegionAAA 5
TgeneDNAH9chr17:11924318chr17:11827131ENST0000026244260693866_409239164487.0RegionAAA 6


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Fusion Gene Sequence for MAP2K4-DNAH9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAP2K4-DNAH9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP2K4-DNAH9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP2K4-DNAH9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource