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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MAP2K5-IQCH (FusionGDB2 ID:51219) |
Fusion Gene Summary for MAP2K5-IQCH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP2K5-IQCH | Fusion gene ID: 51219 | Hgene | Tgene | Gene symbol | MAP2K5 | IQCH | Gene ID | 5607 | 128153 |
| Gene name | mitogen-activated protein kinase kinase 5 | spermatogenesis associated 17 | |
| Synonyms | HsT17454|MAPKK5|MEK5|PRKMK5 | CFAP305|FAP305|IQCH|MOT17|MSRG-11|MSRG11 | |
| Cytomap | 15q23 | 1q41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5 | spermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q13163 | Q86VS3 | |
| Ensembl transtripts involved in fusion gene | ENST00000560591, ENST00000178640, ENST00000340972, ENST00000354498, ENST00000395476, | ENST00000335894, ENST00000358767, ENST00000360277, ENST00000512104, ENST00000546225, ENST00000560790, | |
| Fusion gene scores | * DoF score | 10 X 10 X 9=900 | 8 X 11 X 6=528 |
| # samples | 12 | 12 | |
| ** MAII score | log2(12/900*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAP2K5 [Title/Abstract] AND IQCH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | IQCH(67553732)-MAP2K5(68098984), # samples:2 IQCH(67553732)-MAP2K5(68098983), # samples:2 MAP2K5(67885312)-IQCH(67782341), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | IQCH-MAP2K5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. IQCH-MAP2K5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. IQCH-MAP2K5 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across MAP2K5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across IQCH (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | CESC | TCGA-C5-A7X3-01A | MAP2K5 | chr15 | 67885312 | - | IQCH | chr15 | 67782341 | + |
| ChimerDB4 | CESC | TCGA-C5-A7X3-01A | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| ChimerDB4 | CESC | TCGA-C5-A7X3 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| ChimerDB4 | PRAD | TCGA-EJ-A46G-01A | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
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Fusion Gene ORF analysis for MAP2K5-IQCH |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000560591 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 3UTR-intron | ENST00000560591 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 3UTR-intron | ENST00000560591 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 3UTR-intron | ENST00000560591 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 3UTR-intron | ENST00000560591 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 3UTR-intron | ENST00000560591 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 3UTR-intron | ENST00000560591 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 3UTR-intron | ENST00000560591 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 3UTR-intron | ENST00000560591 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 3UTR-intron | ENST00000560591 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 3UTR-intron | ENST00000560591 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 3UTR-intron | ENST00000560591 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000178640 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000178640 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000178640 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000178640 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000178640 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000178640 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000178640 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000178640 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000178640 | ENST00000512104 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| 5CDS-intron | ENST00000178640 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000178640 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000178640 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000178640 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000178640 | ENST00000560790 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| 5CDS-intron | ENST00000340972 | ENST00000512104 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| 5CDS-intron | ENST00000340972 | ENST00000560790 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| 5CDS-intron | ENST00000354498 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000354498 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000354498 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000354498 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000354498 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000354498 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000354498 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000354498 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000354498 | ENST00000512104 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| 5CDS-intron | ENST00000354498 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000354498 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000354498 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000354498 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000354498 | ENST00000560790 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| 5CDS-intron | ENST00000395476 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000395476 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000395476 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000395476 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000395476 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000395476 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000395476 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000395476 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000395476 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000395476 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| 5CDS-intron | ENST00000395476 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| 5CDS-intron | ENST00000395476 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| In-frame | ENST00000178640 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000178640 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000178640 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000178640 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000340972 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000340972 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000340972 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000340972 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000354498 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000354498 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000354498 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| In-frame | ENST00000354498 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000395476 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000395476 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000395476 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000395476 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000560591 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000560591 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000560591 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-3CDS | ENST00000560591 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-intron | ENST00000340972 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| intron-intron | ENST00000340972 | ENST00000335894 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| intron-intron | ENST00000340972 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| intron-intron | ENST00000340972 | ENST00000358767 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| intron-intron | ENST00000340972 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| intron-intron | ENST00000340972 | ENST00000360277 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| intron-intron | ENST00000340972 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| intron-intron | ENST00000340972 | ENST00000512104 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| intron-intron | ENST00000340972 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| intron-intron | ENST00000340972 | ENST00000546225 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| intron-intron | ENST00000340972 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782341 | + |
| intron-intron | ENST00000340972 | ENST00000560790 | MAP2K5 | chr15 | 67885312 | + | IQCH | chr15 | 67782340 | + |
| intron-intron | ENST00000395476 | ENST00000512104 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-intron | ENST00000395476 | ENST00000560790 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-intron | ENST00000560591 | ENST00000512104 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| intron-intron | ENST00000560591 | ENST00000560790 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000178640 | MAP2K5 | chr15 | 68020283 | - | ENST00000358767 | IQCH | chr15 | 67757465 | + | 3275 | 1701 | 627 | 2078 | 483 |
| ENST00000178640 | MAP2K5 | chr15 | 68020283 | - | ENST00000546225 | IQCH | chr15 | 67757465 | + | 3337 | 1701 | 627 | 2279 | 550 |
| ENST00000178640 | MAP2K5 | chr15 | 68020283 | - | ENST00000335894 | IQCH | chr15 | 67757465 | + | 3338 | 1701 | 627 | 2279 | 550 |
| ENST00000178640 | MAP2K5 | chr15 | 68020283 | - | ENST00000360277 | IQCH | chr15 | 67757465 | + | 3275 | 1701 | 627 | 2078 | 483 |
| ENST00000354498 | MAP2K5 | chr15 | 68020283 | - | ENST00000358767 | IQCH | chr15 | 67757465 | + | 2723 | 1149 | 156 | 1526 | 456 |
| ENST00000354498 | MAP2K5 | chr15 | 68020283 | - | ENST00000546225 | IQCH | chr15 | 67757465 | + | 2785 | 1149 | 156 | 1727 | 523 |
| ENST00000354498 | MAP2K5 | chr15 | 68020283 | - | ENST00000335894 | IQCH | chr15 | 67757465 | + | 2786 | 1149 | 156 | 1727 | 523 |
| ENST00000354498 | MAP2K5 | chr15 | 68020283 | - | ENST00000360277 | IQCH | chr15 | 67757465 | + | 2723 | 1149 | 156 | 1526 | 456 |
| ENST00000340972 | MAP2K5 | chr15 | 68020283 | - | ENST00000358767 | IQCH | chr15 | 67757465 | + | 2429 | 855 | 348 | 1232 | 294 |
| ENST00000340972 | MAP2K5 | chr15 | 68020283 | - | ENST00000546225 | IQCH | chr15 | 67757465 | + | 2491 | 855 | 348 | 1433 | 361 |
| ENST00000340972 | MAP2K5 | chr15 | 68020283 | - | ENST00000335894 | IQCH | chr15 | 67757465 | + | 2492 | 855 | 348 | 1433 | 361 |
| ENST00000340972 | MAP2K5 | chr15 | 68020283 | - | ENST00000360277 | IQCH | chr15 | 67757465 | + | 2429 | 855 | 348 | 1232 | 294 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000178640 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000460768 | 0.99953926 |
| ENST00000178640 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000382053 | 0.99961793 |
| ENST00000178640 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000381576 | 0.9996184 |
| ENST00000178640 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000460768 | 0.99953926 |
| ENST00000354498 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000279324 | 0.99972063 |
| ENST00000354498 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000251626 | 0.9997484 |
| ENST00000354498 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000251587 | 0.9997484 |
| ENST00000354498 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000279324 | 0.99972063 |
| ENST00000340972 | ENST00000358767 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000547516 | 0.99945253 |
| ENST00000340972 | ENST00000546225 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000243844 | 0.99975616 |
| ENST00000340972 | ENST00000335894 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000244004 | 0.99975604 |
| ENST00000340972 | ENST00000360277 | MAP2K5 | chr15 | 68020283 | - | IQCH | chr15 | 67757465 | + | 0.000547516 | 0.99945253 |
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Fusion Genomic Features for MAP2K5-IQCH |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAP2K5-IQCH |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:67553732/chr15:68098984) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP2K5 | IQCH |
| FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}. | FUNCTION: May play a regulatory role in spermatogenesis. {ECO:0000269|PubMed:15897968}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000178640 | - | 17 | 22 | 18_109 | 358 | 449.0 | Domain | PB1 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000354498 | - | 17 | 22 | 18_109 | 322 | 413.0 | Domain | PB1 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000178640 | - | 17 | 22 | 172_180 | 358 | 449.0 | Nucleotide binding | ATP |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000354498 | - | 17 | 22 | 172_180 | 322 | 413.0 | Nucleotide binding | ATP |
| Tgene | IQCH | chr15:68020283 | chr15:67757465 | ENST00000512104 | 0 | 6 | 369_398 | 0 | 169.0 | Domain | IQ |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000178640 | - | 17 | 22 | 166_409 | 358 | 449.0 | Domain | Protein kinase |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000354498 | - | 17 | 22 | 166_409 | 322 | 413.0 | Domain | Protein kinase |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000395476 | - | 1 | 21 | 166_409 | 0 | 439.0 | Domain | Protein kinase |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000395476 | - | 1 | 21 | 18_109 | 0 | 439.0 | Domain | PB1 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000395476 | - | 1 | 21 | 172_180 | 0 | 439.0 | Nucleotide binding | ATP |
| Tgene | IQCH | chr15:68020283 | chr15:67757465 | ENST00000335894 | 15 | 21 | 369_398 | 835 | 1028.0 | Domain | IQ | |
| Tgene | IQCH | chr15:68020283 | chr15:67757465 | ENST00000360277 | 7 | 12 | 369_398 | 496 | 1009.3333333333334 | Domain | IQ | |
| Tgene | IQCH | chr15:68020283 | chr15:67757465 | ENST00000546225 | 14 | 20 | 369_398 | 492 | 685.0 | Domain | IQ |
Top |
Fusion Gene Sequence for MAP2K5-IQCH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >51219_51219_1_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000335894_length(transcript)=3338nt_BP=1701nt CTCCTCCTCCTCTCGCCGCTACCGCCGTCGCCGCCGCCGCAGCCGCCGCCAGTCCGCGCGGCCTCGGGTGGCCGGAGCTCAGCCTGCGCG CGCCGCGCCCTGTGTCTCCGGGTGGGGCAGAAGACTCGCCCCTTGAACCTCCCGCGGGGACTCTCCGTGGTGTGGCGGCCCTGGGGCTCT TTCTTAATAGCCCCGGACTGAGTCCCCTCCAGTCGAGGACCCTCTCCTAGTCCACTGACGAGCGGTGGACACCTGCCGCTGTATCTCCCC CAAACCGAGTCCTTGCCCTGCTGCCTCCTCATACCCACACGGCGGCAGAGACCTTCACCATAGCGTTCGCTCAACTCCAGAACCTTCCGA CCTCCGCTAGTTCCTGCGGGCCTTTGCCCGCTTCCCGGTGCACCCTCCCCGGGAGACACCTCAGACCCCCGACAGCCTGGGCAGGCTCGG TGCCTGCGGGTGCGTTCCTGATCACCCCTCCCCTCTTCCCTCCCCCTCATCCTCCATTCCCTTGTTTTCACCCTCTGTCCTCTGCCCGTC ACTCCCCTTGTCACCTCTTGGAGCCCCCTCCTAACCAGCGGCCAGTGGGTTTCCCATACCCCAGGATGTGAGCCTCTTTAACCTGTAATG CTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGGTGGACTGG ACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAA TATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAA CAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAG GTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAA CTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTAC AAAGCATATCATGTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCT GAATTGGAAATTCTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACA GAATTCATGGATGGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTT ACTTATTTGTGGAGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGAT TTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAG CAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCA ACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGC ACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGC TATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATT GGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACAATCGGCGAG GATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAAT TTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGAT GATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTT TTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTA AAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCT TCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCA GGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAA AGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAG TGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTA GTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAAC ATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGT TAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGT GAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAG GAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGTTTCTGTAATAAAATTAACATTTGT >51219_51219_1_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000335894_length(amino acids)=550AA_BP=357 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKG LTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVW ATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHG IGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLFIIHQEISAPNMQGETNFKTTIADIETILRVTKENKMRFEEEQQSK -------------------------------------------------------------- >51219_51219_2_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000358767_length(transcript)=3275nt_BP=1701nt CTCCTCCTCCTCTCGCCGCTACCGCCGTCGCCGCCGCCGCAGCCGCCGCCAGTCCGCGCGGCCTCGGGTGGCCGGAGCTCAGCCTGCGCG CGCCGCGCCCTGTGTCTCCGGGTGGGGCAGAAGACTCGCCCCTTGAACCTCCCGCGGGGACTCTCCGTGGTGTGGCGGCCCTGGGGCTCT TTCTTAATAGCCCCGGACTGAGTCCCCTCCAGTCGAGGACCCTCTCCTAGTCCACTGACGAGCGGTGGACACCTGCCGCTGTATCTCCCC CAAACCGAGTCCTTGCCCTGCTGCCTCCTCATACCCACACGGCGGCAGAGACCTTCACCATAGCGTTCGCTCAACTCCAGAACCTTCCGA CCTCCGCTAGTTCCTGCGGGCCTTTGCCCGCTTCCCGGTGCACCCTCCCCGGGAGACACCTCAGACCCCCGACAGCCTGGGCAGGCTCGG TGCCTGCGGGTGCGTTCCTGATCACCCCTCCCCTCTTCCCTCCCCCTCATCCTCCATTCCCTTGTTTTCACCCTCTGTCCTCTGCCCGTC ACTCCCCTTGTCACCTCTTGGAGCCCCCTCCTAACCAGCGGCCAGTGGGTTTCCCATACCCCAGGATGTGAGCCTCTTTAACCTGTAATG CTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGGTGGACTGG ACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAA TATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAA CAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAG GTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAA CTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTAC AAAGCATATCATGTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCT GAATTGGAAATTCTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACA GAATTCATGGATGGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTT ACTTATTTGTGGAGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGAT TTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAG CAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCA ACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGC ACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGC TATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATT GGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATC AGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAG ATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCC CAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAG AACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCAT TTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCAC CTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATC GATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATAT TGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTT TTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTG TAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACA TTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATT TCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTA TAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAA >51219_51219_2_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000358767_length(amino acids)=483AA_BP=357 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKG LTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVW ATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHG -------------------------------------------------------------- >51219_51219_3_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000360277_length(transcript)=3275nt_BP=1701nt CTCCTCCTCCTCTCGCCGCTACCGCCGTCGCCGCCGCCGCAGCCGCCGCCAGTCCGCGCGGCCTCGGGTGGCCGGAGCTCAGCCTGCGCG CGCCGCGCCCTGTGTCTCCGGGTGGGGCAGAAGACTCGCCCCTTGAACCTCCCGCGGGGACTCTCCGTGGTGTGGCGGCCCTGGGGCTCT TTCTTAATAGCCCCGGACTGAGTCCCCTCCAGTCGAGGACCCTCTCCTAGTCCACTGACGAGCGGTGGACACCTGCCGCTGTATCTCCCC CAAACCGAGTCCTTGCCCTGCTGCCTCCTCATACCCACACGGCGGCAGAGACCTTCACCATAGCGTTCGCTCAACTCCAGAACCTTCCGA CCTCCGCTAGTTCCTGCGGGCCTTTGCCCGCTTCCCGGTGCACCCTCCCCGGGAGACACCTCAGACCCCCGACAGCCTGGGCAGGCTCGG TGCCTGCGGGTGCGTTCCTGATCACCCCTCCCCTCTTCCCTCCCCCTCATCCTCCATTCCCTTGTTTTCACCCTCTGTCCTCTGCCCGTC ACTCCCCTTGTCACCTCTTGGAGCCCCCTCCTAACCAGCGGCCAGTGGGTTTCCCATACCCCAGGATGTGAGCCTCTTTAACCTGTAATG CTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGGTGGACTGG ACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAA TATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAA CAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAG GTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAA CTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTAC AAAGCATATCATGTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCT GAATTGGAAATTCTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACA GAATTCATGGATGGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTT ACTTATTTGTGGAGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGAT TTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAG CAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCA ACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGC ACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGC TATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATT GGCTATGATGTTGAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATC AGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAG ATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCC CAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAG AACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCAT TTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCAC CTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATC GATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATAT TGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTT TTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTG TAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACA TTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATT TCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTA TAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAA >51219_51219_3_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000360277_length(amino acids)=483AA_BP=357 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKG LTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVW ATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHG -------------------------------------------------------------- >51219_51219_4_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000546225_length(transcript)=3337nt_BP=1701nt CTCCTCCTCCTCTCGCCGCTACCGCCGTCGCCGCCGCCGCAGCCGCCGCCAGTCCGCGCGGCCTCGGGTGGCCGGAGCTCAGCCTGCGCG CGCCGCGCCCTGTGTCTCCGGGTGGGGCAGAAGACTCGCCCCTTGAACCTCCCGCGGGGACTCTCCGTGGTGTGGCGGCCCTGGGGCTCT TTCTTAATAGCCCCGGACTGAGTCCCCTCCAGTCGAGGACCCTCTCCTAGTCCACTGACGAGCGGTGGACACCTGCCGCTGTATCTCCCC CAAACCGAGTCCTTGCCCTGCTGCCTCCTCATACCCACACGGCGGCAGAGACCTTCACCATAGCGTTCGCTCAACTCCAGAACCTTCCGA CCTCCGCTAGTTCCTGCGGGCCTTTGCCCGCTTCCCGGTGCACCCTCCCCGGGAGACACCTCAGACCCCCGACAGCCTGGGCAGGCTCGG TGCCTGCGGGTGCGTTCCTGATCACCCCTCCCCTCTTCCCTCCCCCTCATCCTCCATTCCCTTGTTTTCACCCTCTGTCCTCTGCCCGTC ACTCCCCTTGTCACCTCTTGGAGCCCCCTCCTAACCAGCGGCCAGTGGGTTTCCCATACCCCAGGATGTGAGCCTCTTTAACCTGTAATG CTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGGTGGACTGG ACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAA TATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAA CAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAG GTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAA CTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTAC AAAGCATATCATGTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCT GAATTGGAAATTCTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACA GAATTCATGGATGGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTT ACTTATTTGTGGAGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGAT TTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAG CAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCA ACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGC ACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGC TATGCAGTGATGACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATT GGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACAATCGGCGAG GATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAAT TTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGAT GATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTT TTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTA AAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCT TCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCA GGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAA AGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAG TGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTA GTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAAC ATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGT TAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGT GAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAG GAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGTTTCTGTAATAAAATTAACATTTGT >51219_51219_4_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000178640_IQCH_chr15_67757465_ENST00000546225_length(amino acids)=550AA_BP=357 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKG LTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVW ATGLNLAYSDQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHG IGYDVEERQGTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLFIIHQEISAPNMQGETNFKTTIADIETILRVTKENKMRFEEEQQSK -------------------------------------------------------------- >51219_51219_5_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000335894_length(transcript)=2492nt_BP=855nt AAACTGAATCACCTGCAGGGTCTGACGCCTGCATGGAATGATGAGGGAAATTTAATTTTCCAAGCAAAGTGTGAAGTGTGTGCCACTCCA GCAAATAAACGAAGTCATCCATGACAGCTTGTGATGAATTGCCGTATTTATACTGTATATTTTAATAGCCTCACACTAATTTAAATTGAG CACAGAGTAAATTATAATTCAGTCACTTGACTGCTTATATTTAACTTGACAACTCATCCTTATTTGTCCTGGAGGTGTAGTGGAGAGCAG TGGAAATGCACCAAGGAGATGAGGGATGCATGCTCAAGGCAGAATGTACATATTGAGGGCCAGAGCTAGAGATGAATTTTGATGGAGGAC TTTGAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATTCTTTATAAGTGCGATTCATCATAT ATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGATGGGGGATCTTTGGATGTATATAGG AAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGGAGTTTAAAGATTTTACATAGAGAC GTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCC AAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGA ATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCC CTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGG AAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAAT CTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTT ATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCAT CTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTA AGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGG AATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTT GCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATT AAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAG AAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAG TTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGC CTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCC ACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGT ATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGT AGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCAT TCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATT GTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTG >51219_51219_5_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000335894_length(amino acids)=361AA_BP=168 MMEDFEVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKI LHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYS DQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQ GTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLFIIHQEISAPNMQGETNFKTTIADIETILRVTKENKMRFEEEQQSKDDKNLSKPK -------------------------------------------------------------- >51219_51219_6_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000358767_length(transcript)=2429nt_BP=855nt AAACTGAATCACCTGCAGGGTCTGACGCCTGCATGGAATGATGAGGGAAATTTAATTTTCCAAGCAAAGTGTGAAGTGTGTGCCACTCCA GCAAATAAACGAAGTCATCCATGACAGCTTGTGATGAATTGCCGTATTTATACTGTATATTTTAATAGCCTCACACTAATTTAAATTGAG CACAGAGTAAATTATAATTCAGTCACTTGACTGCTTATATTTAACTTGACAACTCATCCTTATTTGTCCTGGAGGTGTAGTGGAGAGCAG TGGAAATGCACCAAGGAGATGAGGGATGCATGCTCAAGGCAGAATGTACATATTGAGGGCCAGAGCTAGAGATGAATTTTGATGGAGGAC TTTGAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATTCTTTATAAGTGCGATTCATCATAT ATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGATGGGGGATCTTTGGATGTATATAGG AAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGGAGTTTAAAGATTTTACATAGAGAC GTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCC AAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGA ATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCC CTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGG AAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAAT CTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCA GGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGAC CACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAA CCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTT AGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTG TTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAAC TCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATG TAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAA GAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATC ATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCA AAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTAT TCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTG TAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAA AGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGA >51219_51219_6_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000358767_length(amino acids)=294AA_BP=168 MMEDFEVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKI LHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYS DQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVENNR -------------------------------------------------------------- >51219_51219_7_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000360277_length(transcript)=2429nt_BP=855nt AAACTGAATCACCTGCAGGGTCTGACGCCTGCATGGAATGATGAGGGAAATTTAATTTTCCAAGCAAAGTGTGAAGTGTGTGCCACTCCA GCAAATAAACGAAGTCATCCATGACAGCTTGTGATGAATTGCCGTATTTATACTGTATATTTTAATAGCCTCACACTAATTTAAATTGAG CACAGAGTAAATTATAATTCAGTCACTTGACTGCTTATATTTAACTTGACAACTCATCCTTATTTGTCCTGGAGGTGTAGTGGAGAGCAG TGGAAATGCACCAAGGAGATGAGGGATGCATGCTCAAGGCAGAATGTACATATTGAGGGCCAGAGCTAGAGATGAATTTTGATGGAGGAC TTTGAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATTCTTTATAAGTGCGATTCATCATAT ATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGATGGGGGATCTTTGGATGTATATAGG AAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGGAGTTTAAAGATTTTACATAGAGAC GTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCC AAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGA ATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCC CTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGG AAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAAT CTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGAACAATCGGCGAGGATCTCCA GGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGAC CACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAA CCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTT AGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTG TTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAAC TCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATG TAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAA GAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATC ATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCA AAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTAT TCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTG TAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAA AGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGA >51219_51219_7_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000360277_length(amino acids)=294AA_BP=168 MMEDFEVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKI LHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYS DQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVENNR -------------------------------------------------------------- >51219_51219_8_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000546225_length(transcript)=2491nt_BP=855nt AAACTGAATCACCTGCAGGGTCTGACGCCTGCATGGAATGATGAGGGAAATTTAATTTTCCAAGCAAAGTGTGAAGTGTGTGCCACTCCA GCAAATAAACGAAGTCATCCATGACAGCTTGTGATGAATTGCCGTATTTATACTGTATATTTTAATAGCCTCACACTAATTTAAATTGAG CACAGAGTAAATTATAATTCAGTCACTTGACTGCTTATATTTAACTTGACAACTCATCCTTATTTGTCCTGGAGGTGTAGTGGAGAGCAG TGGAAATGCACCAAGGAGATGAGGGATGCATGCTCAAGGCAGAATGTACATATTGAGGGCCAGAGCTAGAGATGAATTTTGATGGAGGAC TTTGAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATTCTTTATAAGTGCGATTCATCATAT ATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGATGGGGGATCTTTGGATGTATATAGG AAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGGAGTTTAAAGATTTTACATAGAGAC GTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCC AAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCATTCTGATGTCTGGAGCTTAGGA ATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAACCTCGCATATAGTGACCAGCTGGCC CTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTGCCCCGCTTTGTTCCAAAGGAAAGG AAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATGACCACCCAGCTAAGACACAGCAAT CTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTTGAGGAAAGGCAAGGAACTGTTTTT ATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCAT CTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTA AGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGG AATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTT GCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATT AAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAG AAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAG TTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGC CTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCC ACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGT ATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGT AGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCAT TCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATT GTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTG >51219_51219_8_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000340972_IQCH_chr15_67757465_ENST00000546225_length(amino acids)=361AA_BP=168 MMEDFEVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKI LHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYS DQLALTQLTLYLTNGHLDCSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQ GTVFILYEHLKRHKLGMLTIGEDLQGVLMTFARHLFIIHQEISAPNMQGETNFKTTIADIETILRVTKENKMRFEEEQQSKDDKNLSKPK -------------------------------------------------------------- >51219_51219_9_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000335894_length(transcript)=2786nt_BP=1149nt GAAGTTGCAGCCACTCTGCTAAGTGCCCTGCTTGGAAAGGCTGTGGGCTCCCTGCTGAGAAATACTGCGAGCGGCTTTGTCAGCCGGCTG CCTGGTGCCAGTTCTGCTGCAGCCTGGGAGGGACACTGTGGCAGAGCTCCTGGAGAGAAATGAGGTTTGCAGGCCATTGGAGTTGGACTG GACATGATGGAGGGTCACTTTCCCCAGAGCGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAATATGAAGATGAA GATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAAT GGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAGGTGAATACTCGG GCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATA CTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATCAT GTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATT CTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGAT GGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGG AGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGC ACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATT CATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAAC CTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTG CCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATG ACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTT GAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGG GTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACC ATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTC TCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAA ATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTA TTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAG AAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGC TTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAAT TGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTC ATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGC ATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTC TAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGT AGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCA AATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTT >51219_51219_9_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000335894_length(amino acids)=523AA_BP=330 MQAIGVGLDMMEGHFPQSDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNI HGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQK QIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQV KLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYSDQLALTQLTLYLTNGHLD CSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGML -------------------------------------------------------------- >51219_51219_10_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000358767_length(transcript)=2723nt_BP=1149nt GAAGTTGCAGCCACTCTGCTAAGTGCCCTGCTTGGAAAGGCTGTGGGCTCCCTGCTGAGAAATACTGCGAGCGGCTTTGTCAGCCGGCTG CCTGGTGCCAGTTCTGCTGCAGCCTGGGAGGGACACTGTGGCAGAGCTCCTGGAGAGAAATGAGGTTTGCAGGCCATTGGAGTTGGACTG GACATGATGGAGGGTCACTTTCCCCAGAGCGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAATATGAAGATGAA GATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAAT GGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAGGTGAATACTCGG GCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATA CTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATCAT GTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATT CTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGAT GGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGG AGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGC ACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATT CATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAAC CTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTG CCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATG ACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTT GAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATAT GCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGA GCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATA AAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAA TGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTG AACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTAC TTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCAT TTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATT TATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAG GATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTC TGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTT TAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTG AGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTT AGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGTTTCTGTAA >51219_51219_10_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000358767_length(amino acids)=456AA_BP=330 MQAIGVGLDMMEGHFPQSDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNI HGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQK QIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQV KLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYSDQLALTQLTLYLTNGHLD CSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVENNRRGSPGGPHDLCSPSLHHP -------------------------------------------------------------- >51219_51219_11_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000360277_length(transcript)=2723nt_BP=1149nt GAAGTTGCAGCCACTCTGCTAAGTGCCCTGCTTGGAAAGGCTGTGGGCTCCCTGCTGAGAAATACTGCGAGCGGCTTTGTCAGCCGGCTG CCTGGTGCCAGTTCTGCTGCAGCCTGGGAGGGACACTGTGGCAGAGCTCCTGGAGAGAAATGAGGTTTGCAGGCCATTGGAGTTGGACTG GACATGATGGAGGGTCACTTTCCCCAGAGCGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAATATGAAGATGAA GATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAAT GGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAGGTGAATACTCGG GCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATA CTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATCAT GTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATT CTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGAT GGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGG AGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGC ACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATT CATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAAC CTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTG CCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATG ACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTT GAGAACAATCGGCGAGGATCTCCAGGGGGTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATAT GCAAGGCGAGACCAATTTTAAGACCACCATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGA GCAACAGTCCAAAGATGATAAAAACCTCTCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATA AAAAGGGCAATTTTTTTTTCTGTTAGAAATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAA TGAAATGCTCTTTTTAAAACATTGTTTATTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTG AACAATCCCTTCTTCTTCTCAAACTCAGAAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTAC TTCCTCATAGGCCTCAGGATTATGTAGCTTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCAT TTATAGGTTTGAATAAAGGCTTAAGAATTGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATT TATATGAATTTTTAAGTGACTATCATTCATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAG GATAAGCCAGCATCTAGTTAACCAAAGCATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTC TGTAGCTTGAATAAACATTTGTATTCTCTAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTT TAAAAAGGCAGACTGTTAAGATTGTAGTAGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTG AGCTTTACTGAAGGGTGAAATAAAAGCAAATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTT AGTGTATTGGGGAAAGGAATAGGATTTTTACCTGTGGAATTTCAATAATTTGTTAACTGTGATTCAGCCACAGGCTAAGAGTTTCTGTAA >51219_51219_11_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000360277_length(amino acids)=456AA_BP=330 MQAIGVGLDMMEGHFPQSDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNI HGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQK QIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQV KLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYSDQLALTQLTLYLTNGHLD CSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVENNRRGSPGGPHDLCSPSLHHP -------------------------------------------------------------- >51219_51219_12_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000546225_length(transcript)=2785nt_BP=1149nt GAAGTTGCAGCCACTCTGCTAAGTGCCCTGCTTGGAAAGGCTGTGGGCTCCCTGCTGAGAAATACTGCGAGCGGCTTTGTCAGCCGGCTG CCTGGTGCCAGTTCTGCTGCAGCCTGGGAGGGACACTGTGGCAGAGCTCCTGGAGAGAAATGAGGTTTGCAGGCCATTGGAGTTGGACTG GACATGATGGAGGGTCACTTTCCCCAGAGCGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAATATGAAGATGAA GATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAAT GGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAGGTGAATACTCGG GCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATA CTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATCAT GTCCCGAGTGGGAAAATATTAGCTGTAAAGGTCATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATT CTTTATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGGATTTCAATATGTACAGAATTCATGGAT GGGGGATCTTTGGATGTATATAGGAAAATGCCAGAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGG AGTTTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAGGTTAAGCTGTGTGATTTTGGAGTTAGC ACTCAGCTGGTGAATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATT CATTCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTCAGGTGTGGGCAACCGGCCTTAAC CTCGCATATAGTGACCAGCTGGCCCTGACTCAACTCACCTTATACCTGACAAACGGCCATCTGGATTGCAGTTTGAGCACCCTGGAAGTG CCCCGCTTTGTTCCAAAGGAAAGGAAGAAAACCAAATGCATGAGTGCGCTGTCAATGCCGATGCTGGCAACCAGTCGCTATGCAGTGATG ACCACCCAGCTAAGACACAGCAATCTCTCACTGGTTTTCCACTATGTTTTTCTCCAGATCTGTAGGGCCCATGGCATTGGCTATGATGTT GAGGAAAGGCAAGGAACTGTTTTTATATTATATGAGCACCTGAAGAGACACAAGTTGGGAATGTTAACAATCGGCGAGGATCTCCAGGGG GTCCTCATGACCTTTGCTCGCCATCTCTTCATCATCCATCAAGAAATATCAGCACCTAATATGCAAGGCGAGACCAATTTTAAGACCACC ATTGCTGATATTGAAACTATTCTAAGAGTAACAAAGGAAAACAAAATGAGATTTGAAGAGGAGCAACAGTCCAAAGATGATAAAAACCTC TCTAAACCCAAGAAATGATCCTGGAATACAGTACATAACAATTTGGATCCCAGTCTGGAATAAAAAGGGCAATTTTTTTTTCTGTTAGAA ATAAAAGCCAGGGGAAATTGGTTTGCTTTGTGTGCTAGGAGGTGAATCAGAACAGATTATAATGAAATGCTCTTTTTAAAACATTGTTTA TTAAGTGATCTTATTTTATTTATTAAACCAAAACTTATTTGTGTTTTCATTTGAGAGTGTTGAACAATCCCTTCTTCTTCTCAAACTCAG AAAAAAGTAATCTGATAAAAGAAGAAAGTTAAAAGTCTTACTGATATCACCTCCGCATTTACTTCCTCATAGGCCTCAGGATTATGTAGC TTTTATTTTTTATGTTTTATAAAGTTTTCTCCTATTTCTAATAGTCCATCGATCTTCTGCATTTATAGGTTTGAATAAAGGCTTAAGAAT TGCTATTTGTCAAAACACAAATGCCTTTTTTTCAAAGCTTCAAATTATATTGAAATTATATTTATATGAATTTTTAAGTGACTATCATTC ATCGTGTTTTTGTTATACCAAGCCACTATTGTCTGCTATTGTTGCCATTTTTCAAAAAGTAGGATAAGCCAGCATCTAGTTAACCAAAGC ATCAGAATGTATCTAGGTGGCAGTATCTGCTCTTAGTTTAAGATGGAGTGTAGCTCGAGCTCTGTAGCTTGAATAAACATTTGTATTCTC TAGTTCTCCATTTAATACAGCAGTAGGATTTTTTCAAGTTTAGTTCAACATTATACTACCTTTAAAAAGGCAGACTGTTAAGATTGTAGT AGTGCTGACTCTAACTTTCAGCATTCACTTCATAATTGTCCAAAAATATTTCCACATCAGTGAGCTTTACTGAAGGGTGAAATAAAAGCA AATTACAACACCAAAACCATTATTGTTTTAAAGAATGACCTTTATGTCTATAAAAATATTTTAGTGTATTGGGGAAAGGAATAGGATTTT >51219_51219_12_MAP2K5-IQCH_MAP2K5_chr15_68020283_ENST00000354498_IQCH_chr15_67757465_ENST00000546225_length(amino acids)=523AA_BP=330 MQAIGVGLDMMEGHFPQSDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNI HGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQK QIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQV KLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQVWATGLNLAYSDQLALTQLTLYLTNGHLD CSLSTLEVPRFVPKERKKTKCMSALSMPMLATSRYAVMTTQLRHSNLSLVFHYVFLQICRAHGIGYDVEERQGTVFILYEHLKRHKLGML -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MAP2K5-IQCH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000178640 | - | 17 | 22 | 64_68 | 358.0 | 449.0 | MAP3K2/MAP3K3 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000354498 | - | 17 | 22 | 64_68 | 322.0 | 413.0 | MAP3K2/MAP3K3 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000178640 | - | 17 | 22 | 117_131 | 358.0 | 449.0 | MAPK7 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000178640 | - | 17 | 22 | 18_25 | 358.0 | 449.0 | MAPK7 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000354498 | - | 17 | 22 | 117_131 | 322.0 | 413.0 | MAPK7 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000354498 | - | 17 | 22 | 18_25 | 322.0 | 413.0 | MAPK7 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000395476 | - | 1 | 21 | 64_68 | 0 | 439.0 | MAP3K2/MAP3K3 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000395476 | - | 1 | 21 | 117_131 | 0 | 439.0 | MAPK7 |
| Hgene | MAP2K5 | chr15:68020283 | chr15:67757465 | ENST00000395476 | - | 1 | 21 | 18_25 | 0 | 439.0 | MAPK7 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAP2K5-IQCH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAP2K5-IQCH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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