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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAP2K5-MYRFL (FusionGDB2 ID:51220)

Fusion Gene Summary for MAP2K5-MYRFL

Fusion gene summary

Fusion gene information	Fusion gene name: MAP2K5-MYRFL
	Fusion gene ID: 51220
		Hgene	Tgene
	Gene symbol	MAP2K5	MYRFL
	Gene ID	5607	196446
	Gene name	mitogen-activated protein kinase kinase 5	myelin regulatory factor like
	Synonyms	HsT17454\|MAPKK5\|MEK5\|PRKMK5	C12orf15\|C12orf28\|bcm1377
	Cytomap	15q23	12q15
	Type of gene	protein-coding	protein-coding
	Description	dual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5	myelin regulatory factor-like protein
	Modification date	20200327	20200322
	UniProtAcc	Q13163	Q96LU7
	Ensembl transtripts involved in fusion gene	ENST00000560591, ENST00000178640, ENST00000354498, ENST00000395476, ENST00000340972,	ENST00000547771, ENST00000552032, ENST00000299350, ENST00000535034,
Fusion gene scores	* DoF score	10 X 10 X 9=900	29 X 16 X 7=3248
	# samples	12	26
	** MAII score	log2(12/900*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/3248*10)=-3.64296810415672 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAP2K5 [Title/Abstract] AND MYRFL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAP2K5(67893087)-MYRFL(70272808), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAP2K5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYRFL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A1L3-01A	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+

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Fusion Gene ORF analysis for MAP2K5-MYRFL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000560591	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
3UTR-3CDS	ENST00000560591	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
3UTR-intron	ENST00000560591	ENST00000299350	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
3UTR-intron	ENST00000560591	ENST00000535034	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
5CDS-intron	ENST00000178640	ENST00000299350	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
5CDS-intron	ENST00000178640	ENST00000535034	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
5CDS-intron	ENST00000354498	ENST00000299350	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
5CDS-intron	ENST00000354498	ENST00000535034	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
5CDS-intron	ENST00000395476	ENST00000299350	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
5CDS-intron	ENST00000395476	ENST00000535034	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
In-frame	ENST00000178640	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
In-frame	ENST00000178640	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
In-frame	ENST00000354498	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
In-frame	ENST00000354498	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
In-frame	ENST00000395476	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
In-frame	ENST00000395476	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
intron-3CDS	ENST00000340972	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
intron-3CDS	ENST00000340972	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
intron-intron	ENST00000340972	ENST00000299350	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+
intron-intron	ENST00000340972	ENST00000535034	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000178640	MAP2K5	chr15	67893087	+	ENST00000552032	MYRFL	chr12	70272808	+	3960	1172	627	3767	1046
ENST00000178640	MAP2K5	chr15	67893087	+	ENST00000547771	MYRFL	chr12	70272808	+	4298	1172	627	3731	1034
ENST00000395476	MAP2K5	chr15	67893087	+	ENST00000552032	MYRFL	chr12	70272808	+	3338	550	5	3145	1046
ENST00000395476	MAP2K5	chr15	67893087	+	ENST00000547771	MYRFL	chr12	70272808	+	3676	550	5	3109	1034
ENST00000354498	MAP2K5	chr15	67893087	+	ENST00000552032	MYRFL	chr12	70272808	+	3408	620	156	3215	1019
ENST00000354498	MAP2K5	chr15	67893087	+	ENST00000547771	MYRFL	chr12	70272808	+	3746	620	156	3179	1007

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000178640	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+	0.000750858	0.99924916
ENST00000178640	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+	0.000240227	0.99975973
ENST00000395476	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+	0.000368142	0.9996319
ENST00000395476	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+	0.00010664	0.9998933
ENST00000354498	ENST00000552032	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+	0.00048392	0.9995161
ENST00000354498	ENST00000547771	MAP2K5	chr15	67893087	+	MYRFL	chr12	70272808	+	0.000195434	0.99980456

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Fusion Genomic Features for MAP2K5-MYRFL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP2K5-MYRFL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:67893087/chr12:70272808)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP2K5 Q13163	MYRFL Q96LU7
FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269\|PubMed:7759517, ECO:0000269\|PubMed:9384584}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000178640

18_109

181

449.0

Domain

PB1

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000354498

18_109

145

413.0

Domain

PB1

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000395476

18_109

181

439.0

Domain

PB1

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000178640

172_180

181

449.0

Nucleotide binding

ATP

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000395476

172_180

181

439.0

Nucleotide binding

ATP

Tgene

MYRFL

chr15:67893087

chr12:70272808

ENST00000552032

543_575

911.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYRFL

chr15:67893087

chr12:70272808

ENST00000552032

142_405

911.0

DNA binding

NDT80

Tgene

MYRFL

chr15:67893087

chr12:70272808

ENST00000552032

451_559

911.0

Domain

Peptidase S74

Tgene

MYRFL

chr15:67893087

chr12:70272808

ENST00000552032

628_648

911.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000178640

166_409

181

449.0

Domain

Protein kinase

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000354498

166_409

145

413.0

Domain

Protein kinase

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000395476

166_409

181

439.0

Domain

Protein kinase

Hgene

MAP2K5

chr15:67893087

chr12:70272808

ENST00000354498

172_180

145

413.0

Nucleotide binding

ATP

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Fusion Gene Sequence for MAP2K5-MYRFL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>51220_51220_1_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000178640_MYRFL_chr12_70272808_ENST00000547771_length(transcript)=4298nt_BP=1172nt
CTCCTCCTCCTCTCGCCGCTACCGCCGTCGCCGCCGCCGCAGCCGCCGCCAGTCCGCGCGGCCTCGGGTGGCCGGAGCTCAGCCTGCGCG
CGCCGCGCCCTGTGTCTCCGGGTGGGGCAGAAGACTCGCCCCTTGAACCTCCCGCGGGGACTCTCCGTGGTGTGGCGGCCCTGGGGCTCT
TTCTTAATAGCCCCGGACTGAGTCCCCTCCAGTCGAGGACCCTCTCCTAGTCCACTGACGAGCGGTGGACACCTGCCGCTGTATCTCCCC
CAAACCGAGTCCTTGCCCTGCTGCCTCCTCATACCCACACGGCGGCAGAGACCTTCACCATAGCGTTCGCTCAACTCCAGAACCTTCCGA
CCTCCGCTAGTTCCTGCGGGCCTTTGCCCGCTTCCCGGTGCACCCTCCCCGGGAGACACCTCAGACCCCCGACAGCCTGGGCAGGCTCGG
TGCCTGCGGGTGCGTTCCTGATCACCCCTCCCCTCTTCCCTCCCCCTCATCCTCCATTCCCTTGTTTTCACCCTCTGTCCTCTGCCCGTC
ACTCCCCTTGTCACCTCTTGGAGCCCCCTCCTAACCAGCGGCCAGTGGGTTTCCCATACCCCAGGATGTGAGCCTCTTTAACCTGTAATG
CTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGGTGGACTGG
ACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAA
TATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAA
CAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAG
GTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAA
CTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTAC
AAGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTG
AGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCT
GGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTG
TCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAG
TGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTC
CAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGG
CACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGAT
GAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATG
GGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAA
GCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTC
AGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCT
AACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGT
GATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTG
GTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAAT
GAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCAT
CAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACC
TTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTT
GAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCA
AGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGA
AAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAAAAGATCAAGACCGA
CGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCC
CTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGG
GGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGACAAAAGCAAATCA
GTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAG
CAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCC
ACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCAT
AGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTA
GCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTC
TTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCAGGAATACA
TTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAG
CTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATGTTTGCTGAAACTTGAAATAATGTGATGTTTGATTTTGCCATGACTATGAA
GAAAACATTTCCTGGAGCAAACAGTTCTGTTGAATTTAAAAATACTATTATTTCTGGTATTAAGGAAGTTGTGAGCTCAAAATAAGGAGA
TCTAGCCTCTATTTTGTTTTAATGTATTTTAAAGCTTTTGAAAAAACCAAAAGGGCCATGTCGACTTCGGCCCACTAAACATAGACTCTT
GAGAATGTGTGATATGGTATGTGGAGGAGATGTGGGGGGTGGTATCTGATACTGAGCTCACATTTAGGCAAATTGTCCTATGTGTGTGTG

>51220_51220_1_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000178640_MYRFL_chr12_70272808_ENST00000547771_length(amino acids)=1034AA_BP=182
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM
EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQS
VSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVP
WHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQS
QADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFEND
SDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTA
HQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASE
ASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCLKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNT
SLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSDKSKSVLARNALSGPDWESDWIDTTISSIQIMEI
QQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLP

--------------------------------------------------------------
>51220_51220_2_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000178640_MYRFL_chr12_70272808_ENST00000552032_length(transcript)=3960nt_BP=1172nt
CTCCTCCTCCTCTCGCCGCTACCGCCGTCGCCGCCGCCGCAGCCGCCGCCAGTCCGCGCGGCCTCGGGTGGCCGGAGCTCAGCCTGCGCG
CGCCGCGCCCTGTGTCTCCGGGTGGGGCAGAAGACTCGCCCCTTGAACCTCCCGCGGGGACTCTCCGTGGTGTGGCGGCCCTGGGGCTCT
TTCTTAATAGCCCCGGACTGAGTCCCCTCCAGTCGAGGACCCTCTCCTAGTCCACTGACGAGCGGTGGACACCTGCCGCTGTATCTCCCC
CAAACCGAGTCCTTGCCCTGCTGCCTCCTCATACCCACACGGCGGCAGAGACCTTCACCATAGCGTTCGCTCAACTCCAGAACCTTCCGA
CCTCCGCTAGTTCCTGCGGGCCTTTGCCCGCTTCCCGGTGCACCCTCCCCGGGAGACACCTCAGACCCCCGACAGCCTGGGCAGGCTCGG
TGCCTGCGGGTGCGTTCCTGATCACCCCTCCCCTCTTCCCTCCCCCTCATCCTCCATTCCCTTGTTTTCACCCTCTGTCCTCTGCCCGTC
ACTCCCCTTGTCACCTCTTGGAGCCCCCTCCTAACCAGCGGCCAGTGGGTTTCCCATACCCCAGGATGTGAGCCTCTTTAACCTGTAATG
CTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGGTGGACTGG
ACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAA
TATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAA
CAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAG
GTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAA
CTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTAC
AAGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTG
AGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCT
GGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTG
TCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAG
TGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTC
CAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGG
CACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGAT
GAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATG
GGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAA
GCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTC
AGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCT
AACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGT
GATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTG
GTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAAT
GAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCAT
CAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACC
TTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTT
GAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCA
AGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGA
AAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTTTGACGATAGTTGCC
CTCTATATACTTAGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTG
CCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTG
CCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTC
CATCAGAGGCGATGGTCAGAAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGAT
ACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAAT
TATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTC
CAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATG
ACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCT
GACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTT
TGGGGACTTTACCAAAGAAAAATACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACAT
TTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATGTTTGCTGAAACTTG

>51220_51220_2_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000178640_MYRFL_chr12_70272808_ENST00000552032_length(amino acids)=1046AA_BP=182
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM
EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQS
VSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVP
WHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQS
QADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFEND
SDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTA
HQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASE
ASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCALTIVALYILSLKDQDRRVPNLPPSNITSSQEPAL
LPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSEDKSKSVLARNALSGPDWESDWI
DTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQE

--------------------------------------------------------------
>51220_51220_3_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000354498_MYRFL_chr12_70272808_ENST00000547771_length(transcript)=3746nt_BP=620nt
GAAGTTGCAGCCACTCTGCTAAGTGCCCTGCTTGGAAAGGCTGTGGGCTCCCTGCTGAGAAATACTGCGAGCGGCTTTGTCAGCCGGCTG
CCTGGTGCCAGTTCTGCTGCAGCCTGGGAGGGACACTGTGGCAGAGCTCCTGGAGAGAAATGAGGTTTGCAGGCCATTGGAGTTGGACTG
GACATGATGGAGGGTCACTTTCCCCAGAGCGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAATATGAAGATGAA
GATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAAT
GGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAGGTGAATACTCGG
GCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATA
CTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTACAAGCAACGCCAG
CTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCT
GGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGAC
TCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTG
GGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCA
CTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGAC
AGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTA
AACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTT
TGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCA
ATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGC
AAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACA
GCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAG
TTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGG
CAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGC
AACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAA
AGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATG
ATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTC
CTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATA
GAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGC
AAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCG
TGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAAAAGATCAAGACCGACGTGTCCCAAAT
CTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACA
CCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAA
GTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGACAAAAGCAAATCAGTTTTGGCAAGA
AATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGAT
CATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAG
TTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGA
ACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCT
GACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTAC
TTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCAGGAATACATTTAACAGAAAC
GAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAGCTTCCAACAGTT
TTGAGACATTAATGAGGAGAATAAAATGTTTGCTGAAACTTGAAATAATGTGATGTTTGATTTTGCCATGACTATGAAGAAAACATTTCC
TGGAGCAAACAGTTCTGTTGAATTTAAAAATACTATTATTTCTGGTATTAAGGAAGTTGTGAGCTCAAAATAAGGAGATCTAGCCTCTAT
TTTGTTTTAATGTATTTTAAAGCTTTTGAAAAAACCAAAAGGGCCATGTCGACTTCGGCCCACTAAACATAGACTCTTGAGAATGTGTGA
TATGGTATGTGGAGGAGATGTGGGGGGTGGTATCTGATACTGAGCTCACATTTAGGCAAATTGTCCTATGTGTGTGTGTATTGTATAAAC

>51220_51220_3_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000354498_MYRFL_chr12_70272808_ENST00000547771_length(amino acids)=1007AA_BP=155
MQAIGVGLDMMEGHFPQSDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNI
HGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKQRQLPDTPPYSASDSCSPPQVKGAC
YPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPT
KKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNF
SPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLG
RLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAP
DEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCG
NGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKV
YFSGKRQACPNWVFQTLVITLIAVMAFCLKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYC
CPIRGMKEVSSSPVQRQSEEKEFHQRRWSDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVN
KHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYF

--------------------------------------------------------------
>51220_51220_4_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000354498_MYRFL_chr12_70272808_ENST00000552032_length(transcript)=3408nt_BP=620nt
GAAGTTGCAGCCACTCTGCTAAGTGCCCTGCTTGGAAAGGCTGTGGGCTCCCTGCTGAGAAATACTGCGAGCGGCTTTGTCAGCCGGCTG
CCTGGTGCCAGTTCTGCTGCAGCCTGGGAGGGACACTGTGGCAGAGCTCCTGGAGAGAAATGAGGTTTGCAGGCCATTGGAGTTGGACTG
GACATGATGGAGGGTCACTTTCCCCAGAGCGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAGCATTTGAATATGAAGATGAA
GATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAAT
GGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAGGTGAATACTCGG
GCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATA
CTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCACAGTCTACAAGCAACGCCAG
CTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACCCAACCCTGAGGCCCACAGCT
GGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGAGCACCTCTGGAATGGGCGAC
TCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACCAATCCGTGTCCTCCCATCTG
GGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGAAGAGAAAGTGCACGCAGGCA
CTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCAGTGAAGTCCAGGACCCTGAC
AGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTGTTCCTTGGCACAGCTTATTA
AACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCACCAGCAGATGAAGCTTTTGTT
TGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAACCGAGATGGGCCTAAAGCCA
ATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAACAGTCCCAAGCAGATAGGAGC
AAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGATTACACTTCAGCGAAACCACA
GCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGTATGCTGCTAACCAAGACCAG
TTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAAATGACAGTGATGCATTGTGG
CAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACGAAGCCCTGGTTGTCTGTGGC
AACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTGACACGAATGAACAGCTGAAA
AGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACACTGCCCATCAAACAGGAATG
ATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACGGAGAGACCTTGGAGAACTTC
CTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTAACAACCTTGAGGAAAGAATA
GAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCAGTGAAGCAAGCACAATCAGC
AAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATTTTTCAGGAAAAAGACAGGCG
TGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTTTGACGATAGTTGCCCTCTATATACTT
AGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCC
TCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAG
ACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGA
TGGTCAGAAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGT
TCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAAT
ATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTC
ACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATAT
CAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACT
GATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTAC
CAAAGAAAAATACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTG

>51220_51220_4_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000354498_MYRFL_chr12_70272808_ENST00000552032_length(amino acids)=1019AA_BP=155
MQAIGVGLDMMEGHFPQSDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNI
HGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKQRQLPDTPPYSASDSCSPPQVKGAC
YPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPPT
KKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNF
SPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQVTKVTLG
RLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAP
DEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEILPRAVREVGDVTCG
NGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKV
YFSGKRQACPNWVFQTLVITLIAVMAFCALTIVALYILSLKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNTSLVTTPASLQVPEITF
CEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQC
GSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLPVAPFSDSMFHFRVAA

--------------------------------------------------------------
>51220_51220_5_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000395476_MYRFL_chr12_70272808_ENST00000547771_length(transcript)=3676nt_BP=550nt
CTGTAATGCTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGG
TGGACTGGACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAG
CATTTGAATATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAG
TAATGGAACAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATG
GCCTGAAGGTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTT
CTGCTGAACTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCA
CAGTCTACAAGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACC
CAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGA
GCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACC
AATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGA
AGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCA
GTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTG
TTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCAC
CAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAA
CCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAAC
AGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGAT
TACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGT
ATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAA
ATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACG
AAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTG
ACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACA
CTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACG
GAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTA
ACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCA
GTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATT
TTTCAGGAAAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGCTTAAAAGATC
AAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAGCTCTGCTGCCCACAGCCTCCTCCTCAGCACCTA
ATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTGAAATCCTGCCGTGTCAGGAGACTTATTGCTGCC
CCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGAAGGAATTCCATCAGAGGCGATGGTCAGACAAAA
GCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACTGGATTGATACAACCATCAGTTCTATTCAGATTATGG
AAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGATCTGGAAATTATAATTACAATATTCCTGTTAATAAAC
ACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGATAGTCTTCCAGTGCAAATTCACCCTTGGAAATATAT
GTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCCAGGAGATGACACAGGGATATCAGCACATTTGGAGCC
TCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGGATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTG
GGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTGTTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCA
GGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTGTAAAACATTTACGTTTATTGCTGAAGGACTTTTTCA
GGCTTTAGCTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATGTTTGCTGAAACTTGAAATAATGTGATGTTTGATTTTGCCATG
ACTATGAAGAAAACATTTCCTGGAGCAAACAGTTCTGTTGAATTTAAAAATACTATTATTTCTGGTATTAAGGAAGTTGTGAGCTCAAAA
TAAGGAGATCTAGCCTCTATTTTGTTTTAATGTATTTTAAAGCTTTTGAAAAAACCAAAAGGGCCATGTCGACTTCGGCCCACTAAACAT
AGACTCTTGAGAATGTGTGATATGGTATGTGGAGGAGATGTGGGGGGTGGTATCTGATACTGAGCTCACATTTAGGCAAATTGTCCTATG

>51220_51220_5_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000395476_MYRFL_chr12_70272808_ENST00000547771_length(amino acids)=1034AA_BP=182
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM
EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQS
VSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVP
WHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQS
QADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFEND
SDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTA
HQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASE
ASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCLKDQDRRVPNLPPSNITSSQEPALLPTASSSAPNT
SLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSDKSKSVLARNALSGPDWESDWIDTTISSIQIMEI
QQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMTQGYQHIWSLP

--------------------------------------------------------------
>51220_51220_6_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000395476_MYRFL_chr12_70272808_ENST00000552032_length(transcript)=3338nt_BP=550nt
CTGTAATGCTGTGGCTAGCCCTTGGCCCCTTTCCTGCCATGGAGAACCAGGTGCTGGTAATTCGCATCAAGATCCCAAATAGTGGCGCGG
TGGACTGGACAGTGCACTCCGGGCCGCAGTTACTCTTCAGGGATGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACAACTACAG
CATTTGAATATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAGGAAATGAAGGCAATGCTGTCATATTATTATTCCACAG
TAATGGAACAGCAAGTAAATGGACAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATG
GCCTGAAGGTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTCTCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTT
CTGCTGAACTGAAAAAAATACTAGCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAACGGAGGCA
CAGTCTACAAGCAACGCCAGCTCCCAGACACCCCGCCCTATTCTGCATCCGACTCATGCTCTCCTCCGCAGGTCAAAGGTGCATGCTACC
CAACCCTGAGGCCCACAGCTGGGAGGACTCCAGCTCCTTTTCTCCACCCCACAGCTGCTCCTGCGATGCCGCCCATGCACCCGCTGCAGA
GCACCTCTGGAATGGGCGACTCCTGCCAAATCCACGGAGGCTTTCACAGCTGCCACTCAAACGCCAGTCATCTTGCCACCCCCCTGGACC
AATCCGTGTCCTCCCATCTGGGGATAGGTTGTTCTTACCCTCAGCAGCCTCTGTGTCACAGCCCTGGAGCCTCATTGCCTCCAACCAAGA
AGAGAAAGTGCACGCAGGCACTGGAGGACTCCGGGGAATGCCGAGTGTGGGCCTGCCACTGCAGACCGATGACAAGTAGGAGTCGCAGCA
GTGAAGTCCAGGACCCTGACAGTGAGGGACAGAACAGAATGCCTACAGACCAGTGCTCTCCTGCTCTGAAGTGGCAACCATGCCATAGTG
TTCCTTGGCACAGCTTATTAAACAGTCATTATGAAAAACTACCTGATGTGGGCTATCGAGTTGTAACAGACAAAGGATTTAATTTTTCAC
CAGCAGATGAAGCTTTTGTTTGCCAAAAGAAGAATCATTTCCAGATAACCATTCACATCCAAGTTTGGGGAAGTCCAAAATTTGTTGAAA
CCGAGATGGGCCTAAAGCCAATAGAAATGTTTTACTTGAAAGTTTTTGGCACTAAGGTGGAAGCTACCAATCAAATAATTGCTATTGAAC
AGTCCCAAGCAGATAGGAGCAAAAAGATTTTCAATCCTGTTAAAATTGACCTACTGGCTGACCAGGTCACCAAAGTAACACTGGGACGAT
TACACTTCAGCGAAACCACAGCAAATAATATGAGAAAAAAGGGAAAACCAAATCCAGACCAGAGATACTTCATGTTGGTGGTTGGACTGT
ATGCTGCTAACCAAGACCAGTTCTATCTGTTGTCTGCCCACATCTCTGAAAGGATCATTGTAAGGGCCTCTAACCCTGGGCAGTTTGAAA
ATGACAGTGATGCATTGTGGCAGCGAGGACAAGTTCCAGAATCTATTGTCTGTCACGGTCGAGTAGGAATCAACACAGATGCGCCGGACG
AAGCCCTGGTTGTCTGTGGCAACATGAAAGTGATGGGGACCATCATGCATCCCTCTGACAGCCGGGCAAAGCAGAATATCCAGGAGGTTG
ACACGAATGAACAGCTGAAAAGAATAGCCCAAATGAGAATTGTTGAATATGACTACAAACCTGAATTTGCATCTGCAATGGGAATAAACA
CTGCCCATCAAACAGGAATGATTGCCCAGGAGGTGCAAGAAATCCTGCCCAGAGCAGTAAGAGAGGTTGGTGATGTCACCTGCGGAAACG
GAGAGACCTTGGAGAACTTCCTCATGGTGGATAAGGACCAGATCTTTATGGAAAATGTAGGTGCAGTGAAGCAACTGTGCAAACTAACTA
ACAACCTTGAGGAAAGAATAGAAGAGTTAGAAATATGGAACAGAAAGCTGGCCCGGCTAAAGCGGCTCAGTAGTTGGAAGTCATCAGCCA
GTGAAGCAAGCACAATCAGCAAATCTAGCAGAGCCGTTAGTGCATCTTCTCCAAGAAGGGCCGTTCATAAAAAAAACAACAAGGTTTATT
TTTCAGGAAAAAGACAGGCGTGTCCTAATTGGGTTTTCCAGACCTTGGTTATAACTCTGATTGCTGTGATGGCATTTTGTGCTTTGACGA
TAGTTGCCCTCTATATACTTAGCTTAAAAGATCAAGACCGACGTGTCCCAAATCTCCCTCCAAGCAATATCACAAGCTCACAGGAGCCAG
CTCTGCTGCCCACAGCCTCCTCCTCAGCACCTAATACATCCCTGGTAACCACACCGGCCTCCTTACAAGTACCTGAAATTACTTTCTGTG
AAATCCTGCCGTGTCAGGAGACTTATTGCTGCCCCATCCGGGGAATGAAAGAAGTCTCTTCAAGTCCTGTGCAAAGACAATCTGAGGAGA
AGGAATTCCATCAGAGGCGATGGTCAGAAGACAAAAGCAAATCAGTTTTGGCAAGAAATGCACTCAGCGGCCCTGACTGGGAGAGTGACT
GGATTGATACAACCATCAGTTCTATTCAGATTATGGAAATCCAGCAAATAATAGATCATCAGTATTGCATTCAAAGCCTCCAGTGCGGAT
CTGGAAATTATAATTACAATATTCCTGTTAATAAACACACACCCACCAATGTCAAGTTCTCTCTGGAAATAAACACAACAGAGCCATTGA
TAGTCTTCCAGTGCAAATTCACCCTTGGAAATATATGTTTCCATAGTAAAAGGGGAACCAAAGGGCTGGAAAGCCACAGAGAAATCTCCC
AGGAGATGACACAGGGATATCAGCACATTTGGAGCCTCCCTGTAGCCCCATTTTCTGACAGCATGTTCCATTTCCGTGTAGCTGCACCGG
ATTTAGCTGACTGTTCAACTGATCCTTATTTTGCTGGGATATTCTTCACCGATTACTTCTTTTACTTCTATCGACGCTGTGCCTAATTTG
TTCAAGTTTGGGGACTTTACCAAAGAAAAATACTCAGGAATACATTTAACAGAAACGAACATCCTCTTGCAACTTCTTTTTTCTTCTTTG
TAAAACATTTACGTTTATTGCTGAAGGACTTTTTCAGGCTTTAGCTTCCAACAGTTTTGAGACATTAATGAGGAGAATAAAATGTTTGCT

>51220_51220_6_MAP2K5-MYRFL_MAP2K5_chr15_67893087_ENST00000395476_MYRFL_chr12_70272808_ENST00000552032_length(amino acids)=1046AA_BP=182
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVM
EQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQSTSGMGDSCQIHGGFHSCHSNASHLATPLDQS
VSSHLGIGCSYPQQPLCHSPGASLPPTKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQPCHSVP
WHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWGSPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQS
QADRSKKIFNPVKIDLLADQVTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERIIVRASNPGQFEND
SDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHPSDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTA
HQTGMIAQEVQEILPRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWNRKLARLKRLSSWKSSASE
ASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWVFQTLVITLIAVMAFCALTIVALYILSLKDQDRRVPNLPPSNITSSQEPAL
LPTASSSAPNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRWSEDKSKSVLARNALSGPDWESDWI
DTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNYNIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MAP2K5-MYRFL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000178640	+	8	22	64_68	181.66666666666666	449.0	MAP3K2/MAP3K3
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000354498	+	8	22	64_68	145.66666666666666	413.0	MAP3K2/MAP3K3
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000395476	+	8	21	64_68	181.66666666666666	439.0	MAP3K2/MAP3K3
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000178640	+	8	22	117_131	181.66666666666666	449.0	MAPK7
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000178640	+	8	22	18_25	181.66666666666666	449.0	MAPK7
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000354498	+	8	22	117_131	145.66666666666666	413.0	MAPK7
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000354498	+	8	22	18_25	145.66666666666666	413.0	MAPK7
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000395476	+	8	21	117_131	181.66666666666666	439.0	MAPK7
Hgene	MAP2K5	chr15:67893087	chr12:70272808	ENST00000395476	+	8	21	18_25	181.66666666666666	439.0	MAPK7

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MAP2K5-MYRFL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MAP2K5-MYRFL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source