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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP3K10-DMKN (FusionGDB2 ID:51245)

Fusion Gene Summary for MAP3K10-DMKN

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP3K10-DMKN
Fusion gene ID: 51245
HgeneTgene
Gene symbol

MAP3K10

DMKN

Gene ID

4294

93099

Gene namemitogen-activated protein kinase kinase kinase 10dermokine
SynonymsMEKK10|MLK2|MSTUNQ729|ZD52F10
Cytomap

19q13.2

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 10MKN28 derived nonreceptor_type serine/threonine kinaseMKN28 kinasemixed lineage kinase 2protein kinase MSTdermokineepidermis-specific secreted protein SK30/SK89
Modification date2020031320200313
UniProtAcc

Q02779

Q6E0U4

Ensembl transtripts involved in fusion geneENST00000253055, ENST00000593906, 
ENST00000339686, ENST00000392206, 
ENST00000402589, ENST00000408915, 
ENST00000414866, ENST00000418261, 
ENST00000419602, ENST00000424570, 
ENST00000429837, ENST00000436012, 
ENST00000440396, ENST00000443640, 
ENST00000447113, ENST00000451297, 
ENST00000458071, ENST00000461300, 
ENST00000462126, ENST00000467637, 
ENST00000472252, ENST00000474928, 
ENST00000480502, ENST00000488892, 
ENST00000492341, ENST00000602781, 
Fusion gene scores* DoF score5 X 8 X 5=2007 X 9 X 6=378
# samples 79
** MAII scorelog2(7/200*10)=-1.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP3K10 [Title/Abstract] AND DMKN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP3K10(40718756)-DMKN(36002431), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K10

GO:0018105

peptidyl-serine phosphorylation

19801649

HgeneMAP3K10

GO:0018107

peptidyl-threonine phosphorylation

19801649


check buttonFusion gene breakpoints across MAP3K10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DMKN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-KH-A6WCMAP3K10chr19

40718753

+DMKNchr19

36002422

-
ChimerDB4ESCATCGA-KH-A6WCMAP3K10chr19

40718756

+DMKNchr19

36002431

-
ChimerDB4ESCATCGA-L5-A88TMAP3K10chr19

40718757

+DMKNchr19

36002418

-
ChimerDB4OVTCGA-13-0768-01AMAP3K10chr19

40718756

+DMKNchr19

36002431

-


Top

Fusion Gene ORF analysis for MAP3K10-DMKN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000253055ENST00000339686MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000339686MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000339686MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000392206MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000392206MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000392206MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000402589MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000402589MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000402589MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000408915MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000408915MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000408915MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000414866MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000414866MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000414866MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000418261MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000418261MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000418261MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000419602MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000419602MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000419602MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000424570MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000424570MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000424570MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000429837MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000429837MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000429837MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000436012MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000436012MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000436012MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000440396MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000440396MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000440396MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000443640MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000443640MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000443640MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000447113MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000447113MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000447113MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000451297MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000451297MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000451297MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000458071MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000458071MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000458071MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000461300MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000461300MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000461300MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000462126MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000462126MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000462126MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000467637MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000467637MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000467637MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000472252MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000472252MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000472252MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000474928MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000474928MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000474928MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000480502MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000480502MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000480502MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000488892MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000488892MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000488892MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000492341MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000492341MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000492341MAP3K10chr19

40718757

+DMKNchr19

36002418

-
5CDS-intronENST00000253055ENST00000602781MAP3K10chr19

40718753

+DMKNchr19

36002422

-
5CDS-intronENST00000253055ENST00000602781MAP3K10chr19

40718756

+DMKNchr19

36002431

-
5CDS-intronENST00000253055ENST00000602781MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000339686MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000339686MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000339686MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000392206MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000392206MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000392206MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000402589MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000402589MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000402589MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000408915MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000408915MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000408915MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000414866MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000414866MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000414866MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000418261MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000418261MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000418261MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000419602MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000419602MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000419602MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000424570MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000424570MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000424570MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000429837MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000429837MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000429837MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000436012MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000436012MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000436012MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000440396MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000440396MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000440396MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000443640MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000443640MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000443640MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000447113MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000447113MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000447113MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000451297MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000451297MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000451297MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000458071MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000458071MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000458071MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000461300MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000461300MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000461300MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000462126MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000462126MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000462126MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000467637MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000467637MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000467637MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000472252MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000472252MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000472252MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000474928MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000474928MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000474928MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000480502MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000480502MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000480502MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000488892MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000488892MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000488892MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000492341MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000492341MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000492341MAP3K10chr19

40718757

+DMKNchr19

36002418

-
intron-intronENST00000593906ENST00000602781MAP3K10chr19

40718753

+DMKNchr19

36002422

-
intron-intronENST00000593906ENST00000602781MAP3K10chr19

40718756

+DMKNchr19

36002431

-
intron-intronENST00000593906ENST00000602781MAP3K10chr19

40718757

+DMKNchr19

36002418

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAP3K10-DMKN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP3K10-DMKN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:40718756/:36002431)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K10

Q02779

DMKN

Q6E0U4

FUNCTION: Activates the JUN N-terminal pathway. {ECO:0000250}.FUNCTION: May act as a soluble regulator of keratinocyte differentiation. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAP3K10-DMKN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAP3K10-DMKN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP3K10-DMKN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP3K10-DMKN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource