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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MAP3K3-BRIP1 (FusionGDB2 ID:51303) |
Fusion Gene Summary for MAP3K3-BRIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP3K3-BRIP1 | Fusion gene ID: 51303 | Hgene | Tgene | Gene symbol | MAP3K3 | BRIP1 | Gene ID | 4215 | 83990 |
| Gene name | mitogen-activated protein kinase kinase kinase 3 | BRCA1 interacting protein C-terminal helicase 1 | |
| Synonyms | MAPKKK3|MEKK3 | BACH1|FANCJ|OF | |
| Cytomap | 17q23.3 | 17q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3 | Fanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1 | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | Q99759 | Q9BX63 | |
| Ensembl transtripts involved in fusion gene | ENST00000361357, ENST00000361733, ENST00000577395, ENST00000579585, ENST00000584573, ENST00000577784, | ENST00000583837, ENST00000259008, ENST00000577598, | |
| Fusion gene scores | * DoF score | 10 X 10 X 8=800 | 12 X 15 X 7=1260 |
| # samples | 13 | 13 | |
| ** MAII score | log2(13/800*10)=-2.62148837674627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1260*10)=-3.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAP3K3 [Title/Abstract] AND BRIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MAP3K3(61744420)-BRIP1(59763526), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP3K3 | GO:0035556 | intracellular signal transduction | 15001576 |
| Hgene | MAP3K3 | GO:0046777 | protein autophosphorylation | 15001576 |
| Tgene | BRIP1 | GO:0006357 | regulation of transcription by RNA polymerase II | 14504288 |
| Fusion gene breakpoints across MAP3K3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across BRIP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRP | TCGA-2Z-A9JI-01A | MAP3K3 | chr17 | 61744420 | - | BRIP1 | chr17 | 59763526 | - |
| ChimerDB4 | KIRP | TCGA-2Z-A9JI-01A | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| ChimerDB4 | KIRP | TCGA-2Z-A9JI | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
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Fusion Gene ORF analysis for MAP3K3-BRIP1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000361357 | ENST00000583837 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| 5CDS-intron | ENST00000361733 | ENST00000583837 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| 5CDS-intron | ENST00000577395 | ENST00000583837 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| 5CDS-intron | ENST00000579585 | ENST00000583837 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| 5CDS-intron | ENST00000584573 | ENST00000583837 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000361357 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000361357 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000361733 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000361733 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000577395 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000577395 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000579585 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000579585 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000584573 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| In-frame | ENST00000584573 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| intron-3CDS | ENST00000577784 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| intron-3CDS | ENST00000577784 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| intron-intron | ENST00000577784 | ENST00000583837 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000579585 | MAP3K3 | chr17 | 61744420 | + | ENST00000259008 | BRIP1 | chr17 | 59763526 | - | 3866 | 661 | 66 | 1835 | 589 |
| ENST00000579585 | MAP3K3 | chr17 | 61744420 | + | ENST00000577598 | BRIP1 | chr17 | 59763526 | - | 2055 | 661 | 66 | 1070 | 334 |
| ENST00000584573 | MAP3K3 | chr17 | 61744420 | + | ENST00000259008 | BRIP1 | chr17 | 59763526 | - | 4135 | 930 | 335 | 2104 | 589 |
| ENST00000584573 | MAP3K3 | chr17 | 61744420 | + | ENST00000577598 | BRIP1 | chr17 | 59763526 | - | 2324 | 930 | 335 | 1339 | 334 |
| ENST00000361733 | MAP3K3 | chr17 | 61744420 | + | ENST00000259008 | BRIP1 | chr17 | 59763526 | - | 4027 | 822 | 320 | 1996 | 558 |
| ENST00000361733 | MAP3K3 | chr17 | 61744420 | + | ENST00000577598 | BRIP1 | chr17 | 59763526 | - | 2216 | 822 | 320 | 1231 | 303 |
| ENST00000361357 | MAP3K3 | chr17 | 61744420 | + | ENST00000259008 | BRIP1 | chr17 | 59763526 | - | 4118 | 913 | 318 | 2087 | 589 |
| ENST00000361357 | MAP3K3 | chr17 | 61744420 | + | ENST00000577598 | BRIP1 | chr17 | 59763526 | - | 2307 | 913 | 318 | 1322 | 334 |
| ENST00000577395 | MAP3K3 | chr17 | 61744420 | + | ENST00000259008 | BRIP1 | chr17 | 59763526 | - | 3757 | 552 | 50 | 1726 | 558 |
| ENST00000577395 | MAP3K3 | chr17 | 61744420 | + | ENST00000577598 | BRIP1 | chr17 | 59763526 | - | 1946 | 552 | 50 | 961 | 303 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000579585 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000381239 | 0.99961877 |
| ENST00000579585 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000766804 | 0.99923325 |
| ENST00000584573 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000425137 | 0.99957484 |
| ENST00000584573 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000977732 | 0.99902225 |
| ENST00000361733 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000625735 | 0.99937433 |
| ENST00000361733 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.002130045 | 0.99786997 |
| ENST00000361357 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000426178 | 0.99957377 |
| ENST00000361357 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000969789 | 0.99903023 |
| ENST00000577395 | ENST00000259008 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.000563335 | 0.9994367 |
| ENST00000577395 | ENST00000577598 | MAP3K3 | chr17 | 61744420 | + | BRIP1 | chr17 | 59763526 | - | 0.001688099 | 0.9983119 |
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Fusion Genomic Features for MAP3K3-BRIP1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAP3K3-BRIP1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:61744420/chr17:59763526) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K3 | BRIP1 |
| FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:9006902}. | FUNCTION: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000361357 | + | 7 | 17 | 44_123 | 198 | 658.0 | Domain | PB1 |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000361733 | + | 6 | 16 | 44_123 | 167 | 627.0 | Domain | PB1 |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000579585 | + | 8 | 18 | 44_123 | 198 | 658.0 | Domain | PB1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000361357 | + | 7 | 17 | 362_622 | 198 | 658.0 | Domain | Protein kinase |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000361733 | + | 6 | 16 | 362_622 | 167 | 627.0 | Domain | Protein kinase |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000579585 | + | 8 | 18 | 362_622 | 198 | 658.0 | Domain | Protein kinase |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000361357 | + | 7 | 17 | 368_376 | 198 | 658.0 | Nucleotide binding | ATP |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000361733 | + | 6 | 16 | 368_376 | 167 | 627.0 | Nucleotide binding | ATP |
| Hgene | MAP3K3 | chr17:61744420 | chr17:59763526 | ENST00000579585 | + | 8 | 18 | 368_376 | 198 | 658.0 | Nucleotide binding | ATP |
| Tgene | BRIP1 | chr17:61744420 | chr17:59763526 | ENST00000259008 | 17 | 20 | 11_442 | 858 | 1250.0 | Domain | Helicase ATP-binding | |
| Tgene | BRIP1 | chr17:61744420 | chr17:59763526 | ENST00000259008 | 17 | 20 | 158_175 | 858 | 1250.0 | Motif | Nuclear localization signal | |
| Tgene | BRIP1 | chr17:61744420 | chr17:59763526 | ENST00000259008 | 17 | 20 | 393_396 | 858 | 1250.0 | Motif | Note=DEAH box | |
| Tgene | BRIP1 | chr17:61744420 | chr17:59763526 | ENST00000259008 | 17 | 20 | 185_192 | 858 | 1250.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for MAP3K3-BRIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >51303_51303_1_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361357_BRIP1_chr17_59763526_ENST00000259008_length(transcript)=4118nt_BP=913nt AGAACGGTGGCCGGACGGAGAGACTGCGGGTCTGAGGGACTGGCGGGCGGGCGGGCCGAGCGGCGCCGCCGAGGCCGGGCTGGGCCGAGC CCAGGAGCGCCCGGGATGTAGCGGGCCACCCTGCCGATGCCACAGCGCCCGGCCGCGGGCGGAGCCGGAGCCGGAGCCTGGGGAGGCGGC GGGGGCCCAGAGCGCAGCCCGCGCCCCCCGCGCGGAGCCAGGCCCGCTGCCGTCCCCGCCGCCCGGGCCCCCGGCATGCAGCCCCGGCTG CGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACTCAATCATGAACGATCTG GTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACTCAAATAGGCAGAAAAAA CACAACAGCAGCAGCTCAGCCCTTCTGAACAGCCCCACAGTAACAACAAGCTCATGTGCAGGGGCCAGTGAGAAAAAGAAATTTTTGAGT GACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAGATGTGGAGCACAAGGTG ACAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAGATGATCTTGATAAAGCA ATTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATAACAGTTCCTCTCCCCAC TCTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCCCCGAGCCCAGAAGCAGG CACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTT TCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTA AAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAG GAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAATGATCCAGTATTCCTG GAAGAAGCAGGGAAAGCAGAAAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAGAGAGTTAGCTGGTCAAGC TTTAATTCTTTGGGACAGTATTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAATAGTGCCTCTAGTCCTCCC CGTTTCAAAACAGAGAAGATGGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTGACAGTAAACACATCGTTT GGATCATGCCCTCAATCAGAAACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCATTCTGAACATCCGCTCTGT TCTGAAGAAGCCCTGGATCCAGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAATAGAGATTTTGAAACAGAA GCAGAAGATGAATCTATCTATTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGACCTAGCTGAAACTGATAGA GGAAATAGATTGGCTAACAATTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAAGTAGATTCAGCCAGAGAA GTGAAAGCTGAGGATTGCATAGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGACATTGATGGTAATGTAAAA ACAACTTGGATAAATGAACTGGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCTTCCAAAAATAAAGGCATG TTTCCTGGTTTTAAGTAATAATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACTCTGTTGTAAGTAATAATT TGTAAATTGAATAAGTGGCATACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTGAGTTTTTGGGTTTTTTTT TTTGAGACAGAGTCTTGGTCTGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCACCTCCAGGTTCAAGTGAT TCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTTTTAGTAGAGATGGGGTTT CACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTGGGATTACAGGTGTGAGCC ACAGTGCCTGGCCCATTCTTGAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCTTAGCTAAATGCAATTTAA AATTATTCAAAGATCCTAGGGCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATTTGTTTTCACACTGATACA TAAAAATTAACAGCAGTCTAATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTCCAAGACTTTTTCAGAGAT CACCATTTGTCTTGAAAGGTTTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAAGTAGTATGCATTTTTAAT TGAAATTGTTTTACATTCTTTGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATATAAAATGCCAAATGAAGT ATTCCAAATTTTCTATTCTAATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTATTATATATTTTTCCTAGT GGATCAGTGAGTAATAAGTACCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACAATTTATCCCCTCTGGTAT TGTTCTAGCATAAGCTTTAGTTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACCCACATTTATAGCTGCAGC TAAAATATGTTTCCTTAGGGCACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAAGCTATATGTCTAATCAAA AATGATTATAAAAGAGGCTCATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACATCTGTTATTCACTGGGCAT TGGGACTTTTTGTGAGTAATTTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTTCAAGTCAAAATTTCCAGT AAGGATTTACTTTACATTTCATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGACATTTAGATTTTTACAGCC TGTTTCTATAGCATTTGATGTTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTAAAGAATTTAGAATATATT AGATCCCATCTAGTATTATATATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAGGTAATTTTTACATTGTTT TGAAAGGGTGAAACAATTTATCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAACGAATAAATACCTGGTAG AAGACAAGAGACTTGGGCTCTACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACCCTTCAGGGAATTAGTTTC ATCTGTAAAATGCAGCGGTTAGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAATGTCTGTTGATATTCTGA >51303_51303_1_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361357_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=589AA_BP=199 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS PENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSE EDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH -------------------------------------------------------------- >51303_51303_2_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361357_BRIP1_chr17_59763526_ENST00000577598_length(transcript)=2307nt_BP=913nt AGAACGGTGGCCGGACGGAGAGACTGCGGGTCTGAGGGACTGGCGGGCGGGCGGGCCGAGCGGCGCCGCCGAGGCCGGGCTGGGCCGAGC CCAGGAGCGCCCGGGATGTAGCGGGCCACCCTGCCGATGCCACAGCGCCCGGCCGCGGGCGGAGCCGGAGCCGGAGCCTGGGGAGGCGGC GGGGGCCCAGAGCGCAGCCCGCGCCCCCCGCGCGGAGCCAGGCCCGCTGCCGTCCCCGCCGCCCGGGCCCCCGGCATGCAGCCCCGGCTG CGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACTCAATCATGAACGATCTG GTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACTCAAATAGGCAGAAAAAA CACAACAGCAGCAGCTCAGCCCTTCTGAACAGCCCCACAGTAACAACAAGCTCATGTGCAGGGGCCAGTGAGAAAAAGAAATTTTTGAGT GACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAGATGTGGAGCACAAGGTG ACAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAGATGATCTTGATAAAGCA ATTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATAACAGTTCCTCTCCCCAC TCTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCCCCGAGCCCAGAAGCAGG CACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTT TCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTA AAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAG GAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAGTATGAAAAGTTCTTCC CATTTACCTTTGATAGAGAAGTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCCTTAAATATGGTGGTTTGT AATATAAGGTGTTATCATAAAATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGACCAGAGCATATTTTCTGG TTTTCCACTAACTGGCTTTGCCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGTAATAGGAAAAAAAAAATG CCTGCCTAGCTATCCCTTCAGGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCATGTAAGTGGTAGATGTTA TTCTAAAGGCTATATAAAAATTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATAGATAGTTCTTATGAACTT ATTTTTAGGAGGTGAGAGACATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCATCTGTATCAGATTGGCAAA CTGTGGCCCATGGGCCAAATTTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCCCATTTATTTACATTTTAG AAACAACAGCAGAGTTGAGTATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACATTATGCTCCACAAAGCCT AAATATTACTATCTGGCCTATGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAGTTGTTTTAATTCATATAT CCAAGGCGGGTGGATCATCCGAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTACTAAAAAAATACAAAAAT TAGCTGGGTGTGGAGGCAGCTGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACTGGGAGGTGGAGGTTGCAG >51303_51303_2_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361357_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=334AA_BP=199 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS -------------------------------------------------------------- >51303_51303_3_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361733_BRIP1_chr17_59763526_ENST00000259008_length(transcript)=4027nt_BP=822nt GGAGAACGGTGGCCGGACGGAGAGACTGCGGGTCTGAGGGACTGGCGGGCGGGCGGGCCGAGCGGCGCCGCCGAGGCCGGGCTGGGCCGA GCCCAGGAGCGCCCGGGATGTAGCGGGCCACCCTGCCGATGCCACAGCGCCCGGCCGCGGGCGGAGCCGGAGCCGGAGCCTGGGGAGGCG GCGGGGGCCCAGAGCGCAGCCCGCGCCCCCCGCGCGGAGCCAGGCCCGCTGCCGTCCCCGCCGCCCGGGCCCCCGGCATGCAGCCCCGGC TGCGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACTCAATCATGAACGATC TGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACTCAAATAGGCAGAGTG ACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAGATGTGGAGCACAAGGTGA CAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAGATGATCTTGATAAAGCAA TTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATAACAGTTCCTCTCCCCACT CTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCCCCGAGCCCAGAAGCAGGC ACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTTT CCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTAA AGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAGG AACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAATGATCCAGTATTCCTGG AAGAAGCAGGGAAAGCAGAAAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAGAGAGTTAGCTGGTCAAGCT TTAATTCTTTGGGACAGTATTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAATAGTGCCTCTAGTCCTCCCC GTTTCAAAACAGAGAAGATGGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTGACAGTAAACACATCGTTTG GATCATGCCCTCAATCAGAAACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCATTCTGAACATCCGCTCTGTT CTGAAGAAGCCCTGGATCCAGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAATAGAGATTTTGAAACAGAAG CAGAAGATGAATCTATCTATTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGACCTAGCTGAAACTGATAGAG GAAATAGATTGGCTAACAATTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAAGTAGATTCAGCCAGAGAAG TGAAAGCTGAGGATTGCATAGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGACATTGATGGTAATGTAAAAA CAACTTGGATAAATGAACTGGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCTTCCAAAAATAAAGGCATGT TTCCTGGTTTTAAGTAATAATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACTCTGTTGTAAGTAATAATTT GTAAATTGAATAAGTGGCATACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTGAGTTTTTGGGTTTTTTTTT TTGAGACAGAGTCTTGGTCTGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCACCTCCAGGTTCAAGTGATT CTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTTTTAGTAGAGATGGGGTTTC ACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTGGGATTACAGGTGTGAGCCA CAGTGCCTGGCCCATTCTTGAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCTTAGCTAAATGCAATTTAAA ATTATTCAAAGATCCTAGGGCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATTTGTTTTCACACTGATACAT AAAAATTAACAGCAGTCTAATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTCCAAGACTTTTTCAGAGATC ACCATTTGTCTTGAAAGGTTTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAAGTAGTATGCATTTTTAATT GAAATTGTTTTACATTCTTTGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATATAAAATGCCAAATGAAGTA TTCCAAATTTTCTATTCTAATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTATTATATATTTTTCCTAGTG GATCAGTGAGTAATAAGTACCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACAATTTATCCCCTCTGGTATT GTTCTAGCATAAGCTTTAGTTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACCCACATTTATAGCTGCAGCT AAAATATGTTTCCTTAGGGCACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAAGCTATATGTCTAATCAAAA ATGATTATAAAAGAGGCTCATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACATCTGTTATTCACTGGGCATT GGGACTTTTTGTGAGTAATTTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTTCAAGTCAAAATTTCCAGTA AGGATTTACTTTACATTTCATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGACATTTAGATTTTTACAGCCT GTTTCTATAGCATTTGATGTTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTAAAGAATTTAGAATATATTA GATCCCATCTAGTATTATATATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAGGTAATTTTTACATTGTTTT GAAAGGGTGAAACAATTTATCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAACGAATAAATACCTGGTAGA AGACAAGAGACTTGGGCTCTACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACCCTTCAGGGAATTAGTTTCA TCTGTAAAATGCAGCGGTTAGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAATGTCTGTTGATATTCTGAG >51303_51303_3_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361733_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=558AA_BP=168 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS IISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTD KCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPED TDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEI -------------------------------------------------------------- >51303_51303_4_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361733_BRIP1_chr17_59763526_ENST00000577598_length(transcript)=2216nt_BP=822nt GGAGAACGGTGGCCGGACGGAGAGACTGCGGGTCTGAGGGACTGGCGGGCGGGCGGGCCGAGCGGCGCCGCCGAGGCCGGGCTGGGCCGA GCCCAGGAGCGCCCGGGATGTAGCGGGCCACCCTGCCGATGCCACAGCGCCCGGCCGCGGGCGGAGCCGGAGCCGGAGCCTGGGGAGGCG GCGGGGGCCCAGAGCGCAGCCCGCGCCCCCCGCGCGGAGCCAGGCCCGCTGCCGTCCCCGCCGCCCGGGCCCCCGGCATGCAGCCCCGGC TGCGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACTCAATCATGAACGATC TGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACTCAAATAGGCAGAGTG ACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAGATGTGGAGCACAAGGTGA CAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAGATGATCTTGATAAAGCAA TTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATAACAGTTCCTCTCCCCACT CTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCCCCGAGCCCAGAAGCAGGC ACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTTT CCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTAA AGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAGG AACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAGTATGAAAAGTTCTTCCC ATTTACCTTTGATAGAGAAGTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCCTTAAATATGGTGGTTTGTA ATATAAGGTGTTATCATAAAATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGACCAGAGCATATTTTCTGGT TTTCCACTAACTGGCTTTGCCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGTAATAGGAAAAAAAAAATGC CTGCCTAGCTATCCCTTCAGGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCATGTAAGTGGTAGATGTTAT TCTAAAGGCTATATAAAAATTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATAGATAGTTCTTATGAACTTA TTTTTAGGAGGTGAGAGACATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCATCTGTATCAGATTGGCAAAC TGTGGCCCATGGGCCAAATTTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCCCATTTATTTACATTTTAGA AACAACAGCAGAGTTGAGTATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACATTATGCTCCACAAAGCCTA AATATTACTATCTGGCCTATGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAGTTGTTTTAATTCATATATC CAAGGCGGGTGGATCATCCGAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTACTAAAAAAATACAAAAATT AGCTGGGTGTGGAGGCAGCTGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACTGGGAGGTGGAGGTTGCAGT >51303_51303_4_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361733_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=303AA_BP=168 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS -------------------------------------------------------------- >51303_51303_5_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000577395_BRIP1_chr17_59763526_ENST00000259008_length(transcript)=3757nt_BP=552nt TGCGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACTCAATCATGAACGATC TGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACTCAAATAGGCAGAGTG ACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAGATGTGGAGCACAAGGTGA CAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAGATGATCTTGATAAAGCAA TTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATAACAGTTCCTCTCCCCACT CTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCCCCGAGCCCAGAAGCAGGC ACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTTT CCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTAA AGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAGG AACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAATGATCCAGTATTCCTGG AAGAAGCAGGGAAAGCAGAAAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAGAGAGTTAGCTGGTCAAGCT TTAATTCTTTGGGACAGTATTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAATAGTGCCTCTAGTCCTCCCC GTTTCAAAACAGAGAAGATGGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTGACAGTAAACACATCGTTTG GATCATGCCCTCAATCAGAAACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCATTCTGAACATCCGCTCTGTT CTGAAGAAGCCCTGGATCCAGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAATAGAGATTTTGAAACAGAAG CAGAAGATGAATCTATCTATTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGACCTAGCTGAAACTGATAGAG GAAATAGATTGGCTAACAATTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAAGTAGATTCAGCCAGAGAAG TGAAAGCTGAGGATTGCATAGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGACATTGATGGTAATGTAAAAA CAACTTGGATAAATGAACTGGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCTTCCAAAAATAAAGGCATGT TTCCTGGTTTTAAGTAATAATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACTCTGTTGTAAGTAATAATTT GTAAATTGAATAAGTGGCATACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTGAGTTTTTGGGTTTTTTTTT TTGAGACAGAGTCTTGGTCTGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCACCTCCAGGTTCAAGTGATT CTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTTTTAGTAGAGATGGGGTTTC ACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTGGGATTACAGGTGTGAGCCA CAGTGCCTGGCCCATTCTTGAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCTTAGCTAAATGCAATTTAAA ATTATTCAAAGATCCTAGGGCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATTTGTTTTCACACTGATACAT AAAAATTAACAGCAGTCTAATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTCCAAGACTTTTTCAGAGATC ACCATTTGTCTTGAAAGGTTTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAAGTAGTATGCATTTTTAATT GAAATTGTTTTACATTCTTTGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATATAAAATGCCAAATGAAGTA TTCCAAATTTTCTATTCTAATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTATTATATATTTTTCCTAGTG GATCAGTGAGTAATAAGTACCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACAATTTATCCCCTCTGGTATT GTTCTAGCATAAGCTTTAGTTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACCCACATTTATAGCTGCAGCT AAAATATGTTTCCTTAGGGCACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAAGCTATATGTCTAATCAAAA ATGATTATAAAAGAGGCTCATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACATCTGTTATTCACTGGGCATT GGGACTTTTTGTGAGTAATTTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTTCAAGTCAAAATTTCCAGTA AGGATTTACTTTACATTTCATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGACATTTAGATTTTTACAGCCT GTTTCTATAGCATTTGATGTTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTAAAGAATTTAGAATATATTA GATCCCATCTAGTATTATATATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAGGTAATTTTTACATTGTTTT GAAAGGGTGAAACAATTTATCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAACGAATAAATACCTGGTAGA AGACAAGAGACTTGGGCTCTACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACCCTTCAGGGAATTAGTTTCA TCTGTAAAATGCAGCGGTTAGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAATGTCTGTTGATATTCTGAG >51303_51303_5_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000577395_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=558AA_BP=168 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS IISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTD KCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPED TDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEI -------------------------------------------------------------- >51303_51303_6_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000577395_BRIP1_chr17_59763526_ENST00000577598_length(transcript)=1946nt_BP=552nt TGCGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACTCAATCATGAACGATC TGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACTCAAATAGGCAGAGTG ACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAGATGTGGAGCACAAGGTGA CAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAGATGATCTTGATAAAGCAA TTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATAACAGTTCCTCTCCCCACT CTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCCCCGAGCCCAGAAGCAGGC ACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGGAATCCTTGGCTGAATTTT CCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACACTTGAAGTGACCTCTTTAA AGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAGCAAAGATATGTGTCCAGG AACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAAGTATGAAAAGTTCTTCCC ATTTACCTTTGATAGAGAAGTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCCTTAAATATGGTGGTTTGTA ATATAAGGTGTTATCATAAAATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGACCAGAGCATATTTTCTGGT TTTCCACTAACTGGCTTTGCCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGTAATAGGAAAAAAAAAATGC CTGCCTAGCTATCCCTTCAGGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCATGTAAGTGGTAGATGTTAT TCTAAAGGCTATATAAAAATTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATAGATAGTTCTTATGAACTTA TTTTTAGGAGGTGAGAGACATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCATCTGTATCAGATTGGCAAAC TGTGGCCCATGGGCCAAATTTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCCCATTTATTTACATTTTAGA AACAACAGCAGAGTTGAGTATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACATTATGCTCCACAAAGCCTA AATATTACTATCTGGCCTATGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAGTTGTTTTAATTCATATATC CAAGGCGGGTGGATCATCCGAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTACTAAAAAAATACAAAAATT AGCTGGGTGTGGAGGCAGCTGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACTGGGAGGTGGAGGTTGCAGT >51303_51303_6_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000577395_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=303AA_BP=168 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS -------------------------------------------------------------- >51303_51303_7_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000579585_BRIP1_chr17_59763526_ENST00000259008_length(transcript)=3866nt_BP=661nt TTGTTTTTCGGAGCGTTCCTGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAAC TCAATCATGAACGATCTGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCAC TCAAATAGGCAGAAAAAACACAACAGCAGCAGCTCAGCCCTTCTGAACAGCCCCACAGTAACAACAAGCTCATGTGCAGGGGCCAGTGAG AAAAAGAAATTTTTGAGTGACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAA GATGTGGAGCACAAGGTGACAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAA GATGATCTTGATAAAGCAATTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCAT AACAGTTCCTCTCCCCACTCTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCC CCCGAGCCCAGAAGCAGGCACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTG GAATCCTTGGCTGAATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACA CTTGAAGTGACCTCTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAA GCAAAGATATGTGTCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAA AATGATCCAGTATTCCTGGAAGAAGCAGGGAAAGCAGAAAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAG AGAGTTAGCTGGTCAAGCTTTAATTCTTTGGGACAGTATTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAAT AGTGCCTCTAGTCCTCCCCGTTTCAAAACAGAGAAGATGGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTG ACAGTAAACACATCGTTTGGATCATGCCCTCAATCAGAAACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCAT TCTGAACATCCGCTCTGTTCTGAAGAAGCCCTGGATCCAGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAAT AGAGATTTTGAAACAGAAGCAGAAGATGAATCTATCTATTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGAC CTAGCTGAAACTGATAGAGGAAATAGATTGGCTAACAATTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAA GTAGATTCAGCCAGAGAAGTGAAAGCTGAGGATTGCATAGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGAC ATTGATGGTAATGTAAAAACAACTTGGATAAATGAACTGGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCT TCCAAAAATAAAGGCATGTTTCCTGGTTTTAAGTAATAATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACT CTGTTGTAAGTAATAATTTGTAAATTGAATAAGTGGCATACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTG AGTTTTTGGGTTTTTTTTTTTGAGACAGAGTCTTGGTCTGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCA CCTCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTT TTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTG GGATTACAGGTGTGAGCCACAGTGCCTGGCCCATTCTTGAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCT TAGCTAAATGCAATTTAAAATTATTCAAAGATCCTAGGGCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATT TGTTTTCACACTGATACATAAAAATTAACAGCAGTCTAATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTC CAAGACTTTTTCAGAGATCACCATTTGTCTTGAAAGGTTTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAA GTAGTATGCATTTTTAATTGAAATTGTTTTACATTCTTTGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATA TAAAATGCCAAATGAAGTATTCCAAATTTTCTATTCTAATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTA TTATATATTTTTCCTAGTGGATCAGTGAGTAATAAGTACCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACA ATTTATCCCCTCTGGTATTGTTCTAGCATAAGCTTTAGTTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACC CACATTTATAGCTGCAGCTAAAATATGTTTCCTTAGGGCACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAA GCTATATGTCTAATCAAAAATGATTATAAAAGAGGCTCATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACAT CTGTTATTCACTGGGCATTGGGACTTTTTGTGAGTAATTTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTT CAAGTCAAAATTTCCAGTAAGGATTTACTTTACATTTCATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGAC ATTTAGATTTTTACAGCCTGTTTCTATAGCATTTGATGTTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTA AAGAATTTAGAATATATTAGATCCCATCTAGTATTATATATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAG GTAATTTTTACATTGTTTTGAAAGGGTGAAACAATTTATCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAA CGAATAAATACCTGGTAGAAGACAAGAGACTTGGGCTCTACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACC CTTCAGGGAATTAGTTTCATCTGTAAAATGCAGCGGTTAGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAA >51303_51303_7_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000579585_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=589AA_BP=199 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS PENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSE EDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH -------------------------------------------------------------- >51303_51303_8_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000579585_BRIP1_chr17_59763526_ENST00000577598_length(transcript)=2055nt_BP=661nt TTGTTTTTCGGAGCGTTCCTGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAAC TCAATCATGAACGATCTGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCAC TCAAATAGGCAGAAAAAACACAACAGCAGCAGCTCAGCCCTTCTGAACAGCCCCACAGTAACAACAAGCTCATGTGCAGGGGCCAGTGAG AAAAAGAAATTTTTGAGTGACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAA GATGTGGAGCACAAGGTGACAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAA GATGATCTTGATAAAGCAATTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCAT AACAGTTCCTCTCCCCACTCTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCC CCCGAGCCCAGAAGCAGGCACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTG GAATCCTTGGCTGAATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACA CTTGAAGTGACCTCTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAA GCAAAGATATGTGTCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAA AGTATGAAAAGTTCTTCCCATTTACCTTTGATAGAGAAGTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCC TTAAATATGGTGGTTTGTAATATAAGGTGTTATCATAAAATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGA CCAGAGCATATTTTCTGGTTTTCCACTAACTGGCTTTGCCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGT AATAGGAAAAAAAAAATGCCTGCCTAGCTATCCCTTCAGGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCA TGTAAGTGGTAGATGTTATTCTAAAGGCTATATAAAAATTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATA GATAGTTCTTATGAACTTATTTTTAGGAGGTGAGAGACATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCAT CTGTATCAGATTGGCAAACTGTGGCCCATGGGCCAAATTTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCC CATTTATTTACATTTTAGAAACAACAGCAGAGTTGAGTATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACA TTATGCTCCACAAAGCCTAAATATTACTATCTGGCCTATGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAG TTGTTTTAATTCATATATCCAAGGCGGGTGGATCATCCGAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTA CTAAAAAAATACAAAAATTAGCTGGGTGTGGAGGCAGCTGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACT >51303_51303_8_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000579585_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=334AA_BP=199 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS -------------------------------------------------------------- >51303_51303_9_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000584573_BRIP1_chr17_59763526_ENST00000259008_length(transcript)=4135nt_BP=930nt GAGCGTTCCTGAGGTGGAGAACGGTGGCCGGACGGAGAGACTGCGGGTCTGAGGGACTGGCGGGCGGGCGGGCCGAGCGGCGCCGCCGAG GCCGGGCTGGGCCGAGCCCAGGAGCGCCCGGGATGTAGCGGGCCACCCTGCCGATGCCACAGCGCCCGGCCGCGGGCGGAGCCGGAGCCG GAGCCTGGGGAGGCGGCGGGGGCCCAGAGCGCAGCCCGCGCCCCCCGCGCGGAGCCAGGCCCGCTGCCGTCCCCGCCGCCCGGGCCCCCG GCATGCAGCCCCGGCTGCGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACT CAATCATGAACGATCTGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACT CAAATAGGCAGAAAAAACACAACAGCAGCAGCTCAGCCCTTCTGAACAGCCCCACAGTAACAACAAGCTCATGTGCAGGGGCCAGTGAGA AAAAGAAATTTTTGAGTGACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAG ATGTGGAGCACAAGGTGACAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAG ATGATCTTGATAAAGCAATTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATA ACAGTTCCTCTCCCCACTCTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCC CCGAGCCCAGAAGCAGGCACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGG AATCCTTGGCTGAATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACAC TTGAAGTGACCTCTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAG CAAAGATATGTGTCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAA ATGATCCAGTATTCCTGGAAGAAGCAGGGAAAGCAGAAAAAATTGTGATTTCCAGATCCACAAGCCCAACTTTCAACAAACAAACAAAGA GAGTTAGCTGGTCAAGCTTTAATTCTTTGGGACAGTATTTTACTGGTAAAATACCGAAGGCAACACCTGAGCTCGGGTCATCAGAGAATA GTGCCTCTAGTCCTCCCCGTTTCAAAACAGAGAAGATGGAAAGTAAAACTGTTTTGCCCTTCACTGATAAATGTGAATCCTCAAATCTGA CAGTAAACACATCGTTTGGATCATGCCCTCAATCAGAAACCATTATTTCATCATTAAAGATTGATGCCACCCTTACTAGAAAAAATCATT CTGAACATCCGCTCTGTTCTGAAGAAGCCCTGGATCCAGACATTGAATTGTCTCTAGTAAGTGAAGAAGATAAACAGTCCACTTCAAATA GAGATTTTGAAACAGAAGCAGAAGATGAATCTATCTATTTTACACCTGAACTTTATGATCCTGAAGATACAGATGAAGAAAAAAATGACC TAGCTGAAACTGATAGAGGAAATAGATTGGCTAACAATTCAGATTGCATTTTAGCTAAAGACCTTTTTGAAATTAGAACTATAAAAGAAG TAGATTCAGCCAGAGAAGTGAAAGCTGAGGATTGCATAGATACAAAGTTGAATGGAATTCTGCATATTGAAGAAAGTAAAATTGATGACA TTGATGGTAATGTAAAAACAACTTGGATAAATGAACTGGAACTGGGAAAAACTCATGAAATAGAAATAAAGAACTTTAAACCATCTCCTT CCAAAAATAAAGGCATGTTTCCTGGTTTTAAGTAATAATACTTAACTCTCAAGCTAAGTAAAAATATGTCATCATGCTTATGTTAAACTC TGTTGTAAGTAATAATTTGTAAATTGAATAAGTGGCATACTTTTTAAAAAACTATTTTATGTTCAGAAATGTAAATGTTATTATTCTTGA GTTTTTGGGTTTTTTTTTTTGAGACAGAGTCTTGGTCTGTTGCCCAGGCTGGAATGCAGTGGTGTGCTCTGGGCTCACTGCAACCTTCAC CTCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTTCTGAGTAGCTGGGACTACAGGTGTGCACCACCATGCCCAGCTAGTTTTTGTATTTT TAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCGTGATCTGCCCTTCTCTGCCTCCCTAAGTTGCTGG GATTACAGGTGTGAGCCACAGTGCCTGGCCCATTCTTGAGTTTTGATAAAGTAATTCATACAAAGTACTGTCCTCAAATAAGTCTTCCTT AGCTAAATGCAATTTAAAATTATTCAAAGATCCTAGGGCACTTCTAGTTTCACGTAAATATTCATATTAGGTGGTTCTCTTCATCCATTT GTTTTCACACTGATACATAAAAATTAACAGCAGTCTAATCTAGTGACACCTCAGTCATATTTCGCTATAGATTTTACCTCAAATCAGTCC AAGACTTTTTCAGAGATCACCATTTGTCTTGAAAGGTTTATTTCGTTATTAAACTGCCTACTTATAAGTAATTAAGAGAAATTAAGAAAG TAGTATGCATTTTTAATTGAAATTGTTTTACATTCTTTGTATAATAAACCTAAAACCAAACATGTCATAAACAAATTGACGTAAAGATAT AAAATGCCAAATGAAGTATTCCAAATTTTCTATTCTAATTATTTAGCTTCACCATCATTGTGGAAAAAAATACTAGATCCTGCTTAGTAT TATATATTTTTCCTAGTGGATCAGTGAGTAATAAGTACCAAACACTAGACTAGAAGGTAATTTCTACATTGTTTAGAAAGGGTGAAACAA TTTATCCCCTCTGGTATTGTTCTAGCATAAGCTTTAGTTATACAATGATTAAGATAGAAAACTTCATATATAAATTTGATAAGCAAACCC ACATTTATAGCTGCAGCTAAAATATGTTTCCTTAGGGCACAGTAATCCTTTCTGTGAATTTTGACCTTGTTTGTGTTTTTGTGAATGAAG CTATATGTCTAATCAAAAATGATTATAAAAGAGGCTCATCTCTGACATCATTCCAAAAATACATTCATTGATCTCTTTTTAAGAAACATC TGTTATTCACTGGGCATTGGGACTTTTTGTGAGTAATTTGAATTGAAATTTTATGAGCTATCCAAGAATTCTGTATGGTCTATTATTTTC AAGTCAAAATTTCCAGTAAGGATTTACTTTACATTTCATTTGGATAAATGAATCATTATATAGGTATGTCTTTGCTTCCATTTTGAGACA TTTAGATTTTTACAGCCTGTTTCTATAGCATTTGATGTTACAACTCTAAGCGTAGTTCAAAGACATTTAAATTGACAAGTTACCAGTTAA AGAATTTAGAATATATTAGATCCCATCTAGTATTATATATTTTTTCTAGTTGATCATTGAGCAGTAAATACCAAATACTCGATTAGAAGG TAATTTTTACATTGTTTTGAAAGGGTGAAACAATTTATCTCCTCTGGTATTATTCTTAAACCACAGATAGGGATAGTAGGGTAGTGAAAC GAATAAATACCTGGTAGAAGACAAGAGACTTGGGCTCTACACCTGGCTCTGCCACTGATTTGCTAAGTCATATTGGCAATCACCACACCC TTCAGGGAATTAGTTTCATCTGTAAAATGCAGCGGTTAGTACTATAAAATCATACAAATTTCTTTGTGCTTTGAGAATCTATAAAGGAAT >51303_51303_9_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000584573_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=589AA_BP=199 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS PENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSE EDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH -------------------------------------------------------------- >51303_51303_10_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000584573_BRIP1_chr17_59763526_ENST00000577598_length(transcript)=2324nt_BP=930nt GAGCGTTCCTGAGGTGGAGAACGGTGGCCGGACGGAGAGACTGCGGGTCTGAGGGACTGGCGGGCGGGCGGGCCGAGCGGCGCCGCCGAG GCCGGGCTGGGCCGAGCCCAGGAGCGCCCGGGATGTAGCGGGCCACCCTGCCGATGCCACAGCGCCCGGCCGCGGGCGGAGCCGGAGCCG GAGCCTGGGGAGGCGGCGGGGGCCCAGAGCGCAGCCCGCGCCCCCCGCGCGGAGCCAGGCCCGCTGCCGTCCCCGCCGCCCGGGCCCCCG GCATGCAGCCCCGGCTGCGGAGGTGACACTCACGGACCTTAGCCACCGCCGCCGCCATCGCCACCATGGACGAACAGGAGGCATTGAACT CAATCATGAACGATCTGGTGGCCCTCCAGATGAACCGACGTCACCGGATGCCTGGATATGAGACCATGAAGAACAAAGACACAGGTCACT CAAATAGGCAGAAAAAACACAACAGCAGCAGCTCAGCCCTTCTGAACAGCCCCACAGTAACAACAAGCTCATGTGCAGGGGCCAGTGAGA AAAAGAAATTTTTGAGTGACGTCAGAATCAAGTTCGAGCACAACGGGGAGAGGCGAATTATAGCGTTCAGCCGGCCTGTGAAATATGAAG ATGTGGAGCACAAGGTGACAACAGTATTTGGACAACCTCTTGATCTACATTACATGAACAATGAGCTCTCCATCCTGCTGAAAAACCAAG ATGATCTTGATAAAGCAATTGACATTTTAGATAGAAGCTCAAGCATGAAAAGCCTTAGGATATTGCTGTTGTCCCAGGACAGAAACCATA ACAGTTCCTCTCCCCACTCTGGGGTGTCCAGACAGGTGCGGATCAAGGCTTCCCAGTCCGCAGGGGATATAAATACTATCTACCAGCCCC CCGAGCCCAGAAGCAGGCACCTCTCTGTCAGACTTTCTAAATGGGTACGGCAGCAGATTCAGCACCATTCAACCTTTGAAAGTGCACTGG AATCCTTGGCTGAATTTTCCAAAAAGCATCAAAAAGTTCTTAATGTATCCATAAAGGACAGAACCAATATACAGGACAATGAGTCTACAC TTGAAGTGACCTCTTTAAAGTACAGTACCTCACCTTATTTACTGGAAGCAGCAAGTCATCTATCACCAGAAAATTTTGTGGAAGATGAAG CAAAGATATGTGTCCAGGAACTACAGTGTCCTAAAATTATTACCAAAAATTCACCTCTACCAAGTAGCATTATCTCCAGAAAGGAGAAAA GTATGAAAAGTTCTTCCCATTTACCTTTGATAGAGAAGTCTTTCATTATATTTAGTGAAATGATATTTATTTGGGTATAGATTAATTCCT TAAATATGGTGGTTTGTAATATAAGGTGTTATCATAAAATAGTGAAACAGTATGGTGTACTGTAATGGGAACAAACTTTTGTCAGGAGAC CAGAGCATATTTTCTGGTTTTCCACTAACTGGCTTTGCCACTTACTAGCTTTGTGATCATGAGCAAGTCATTTGTCCTTTTTGAGTCGTA ATAGGAAAAAAAAAATGCCTGCCTAGCTATCCCTTCAGGTTGGGTTGTAAAGGTCAAAATTATAAATATCACAGCATTGTAAAGTACCAT GTAAGTGGTAGATGTTATTCTAAAGGCTATATAAAAATTTGGCCTAATTTTTATGTAGATACTTCTATATGAACTACTTTTCCTATATAG ATAGTTCTTATGAACTTATTTTTAGGAGGTGAGAGACATTTATTTTAAGTGATGAAAAATAATATTTTAAAATATTTTGAAATAATCATC TGTATCAGATTGGCAAACTGTGGCCCATGGGCCAAATTTGGCCTGCTGCCTGTTTTTGTAAATAAAGTTTAATGAAATGTAGTCATGCCC ATTTATTTACATTTTAGAAACAACAGCAGAGTTGAGTATTTGTGTGTATTGCACTAGAACAGCATAATTGAGTAGTCGCAACAGATACAT TATGCTCCACAAAGCCTAAATATTACTATCTGGCCTATGACAGAAAAGGTTTGCCAAACTCTGGTCTATTCCATTGGATATAATTTCAGT TGTTTTAATTCATATATCCAAGGCGGGTGGATCATCCGAGGTCAGGAGTCCGAGACCAGCCTGACCAGTGTGGTGAAACACCGTCTCTAC TAAAAAAATACAAAAATTAGCTGGGTGTGGAGGCAGCTGTCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACTG >51303_51303_10_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000584573_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=334AA_BP=199 MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MAP3K3-BRIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | BRIP1 | chr17:61744420 | chr17:59763526 | ENST00000259008 | 17 | 20 | 888_1063 | 858.3333333333334 | 1250.0 | BRCA1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAP3K3-BRIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAP3K3-BRIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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