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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4K1-SUMF2 (FusionGDB2 ID:51385)

Fusion Gene Summary for MAP4K1-SUMF2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K1-SUMF2
Fusion gene ID: 51385
HgeneTgene
Gene symbol

MAP4K1

SUMF2

Gene ID

11184

25870

Gene namemitogen-activated protein kinase kinase kinase kinase 1sulfatase modifying factor 2
SynonymsHPK1pFGE
Cytomap

19q13.2

7p11.2

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 1MAPK/ERK kinase kinase kinase 1MEK kinase kinase 1MEKKK 1hematopoietic progenitor kinase 1inactive C-alpha-formylglycine-generating enzyme 2C-alpha-formyglycine-generating enzyme 2C-alpha-formylglycine-generating enzyme 2epididymis secretory sperm binding proteinparalog of formylglycine-generating enzymeparalog of the formylglycine-genera
Modification date2020032720200313
UniProtAcc

Q92918

.
Ensembl transtripts involved in fusion geneENST00000396857, ENST00000586296, 
ENST00000589130, ENST00000591517, 
ENST00000423454, ENST00000589002, 
ENST00000342190, ENST00000395435, 
ENST00000413756, ENST00000437307, 
ENST00000275607, ENST00000395436, 
ENST00000434526, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 6 X 3=90
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4K1 [Title/Abstract] AND SUMF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4K1(39106835)-SUMF2(56144527), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K1

GO:0006468

protein phosphorylation

8824585

HgeneMAP4K1

GO:0007257

activation of JUN kinase activity

8824585

HgeneMAP4K1

GO:0018105

peptidyl-serine phosphorylation

11053428|24362026

HgeneMAP4K1

GO:0046777

protein autophosphorylation

8824585|24362026

HgeneMAP4K1

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

8824585


check buttonFusion gene breakpoints across MAP4K1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUMF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01AMAP4K1chr19

39106835

-SUMF2chr7

56144527

+


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Fusion Gene ORF analysis for MAP4K1-SUMF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000396857ENST00000342190MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000396857ENST00000395435MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000396857ENST00000413756MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000396857ENST00000437307MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000586296ENST00000342190MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000586296ENST00000395435MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000586296ENST00000413756MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000586296ENST00000437307MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000589130ENST00000342190MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000589130ENST00000395435MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000589130ENST00000413756MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000589130ENST00000437307MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000591517ENST00000342190MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000591517ENST00000395435MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000591517ENST00000413756MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
5CDS-intronENST00000591517ENST00000437307MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000396857ENST00000275607MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000396857ENST00000395436MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000396857ENST00000434526MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000586296ENST00000275607MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000586296ENST00000395436MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000586296ENST00000434526MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000589130ENST00000275607MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000589130ENST00000395436MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000589130ENST00000434526MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000591517ENST00000275607MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000591517ENST00000395436MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
In-frameENST00000591517ENST00000434526MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-3CDSENST00000423454ENST00000275607MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-3CDSENST00000423454ENST00000395436MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-3CDSENST00000423454ENST00000434526MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-3CDSENST00000589002ENST00000275607MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-3CDSENST00000589002ENST00000395436MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-3CDSENST00000589002ENST00000434526MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000423454ENST00000342190MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000423454ENST00000395435MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000423454ENST00000413756MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000423454ENST00000437307MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000589002ENST00000342190MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000589002ENST00000395435MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000589002ENST00000413756MAP4K1chr19

39106835

-SUMF2chr7

56144527

+
intron-intronENST00000589002ENST00000437307MAP4K1chr19

39106835

-SUMF2chr7

56144527

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591517MAP4K1chr1939106835-ENST00000395436SUMF2chr756144527+122534229712227
ENST00000591517MAP4K1chr1939106835-ENST00000275607SUMF2chr756144527+177034229712227
ENST00000591517MAP4K1chr1939106835-ENST00000434526SUMF2chr756144527+177134229712227
ENST00000586296MAP4K1chr1939106835-ENST00000395436SUMF2chr756144527+126738471754227
ENST00000586296MAP4K1chr1939106835-ENST00000275607SUMF2chr756144527+181238471754227
ENST00000586296MAP4K1chr1939106835-ENST00000434526SUMF2chr756144527+181338471754227
ENST00000589130MAP4K1chr1939106835-ENST00000395436SUMF2chr756144527+128239998769223
ENST00000589130MAP4K1chr1939106835-ENST00000275607SUMF2chr756144527+182739998769223
ENST00000589130MAP4K1chr1939106835-ENST00000434526SUMF2chr756144527+182839998769223
ENST00000396857MAP4K1chr1939106835-ENST00000395436SUMF2chr756144527+1304421108791227
ENST00000396857MAP4K1chr1939106835-ENST00000275607SUMF2chr756144527+1849421108791227
ENST00000396857MAP4K1chr1939106835-ENST00000434526SUMF2chr756144527+1850421108791227

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591517ENST00000395436MAP4K1chr1939106835-SUMF2chr756144527+0.0035793910.9964206
ENST00000591517ENST00000275607MAP4K1chr1939106835-SUMF2chr756144527+0.0038162560.9961837
ENST00000591517ENST00000434526MAP4K1chr1939106835-SUMF2chr756144527+0.0038294990.99617046
ENST00000586296ENST00000395436MAP4K1chr1939106835-SUMF2chr756144527+0.0041805740.99581945
ENST00000586296ENST00000275607MAP4K1chr1939106835-SUMF2chr756144527+0.0045433890.9954566
ENST00000586296ENST00000434526MAP4K1chr1939106835-SUMF2chr756144527+0.00456260.99543744
ENST00000589130ENST00000395436MAP4K1chr1939106835-SUMF2chr756144527+0.0031711150.99682885
ENST00000589130ENST00000275607MAP4K1chr1939106835-SUMF2chr756144527+0.0036565530.99634343
ENST00000589130ENST00000434526MAP4K1chr1939106835-SUMF2chr756144527+0.0036728410.9963271
ENST00000396857ENST00000395436MAP4K1chr1939106835-SUMF2chr756144527+0.0045845450.99541545
ENST00000396857ENST00000275607MAP4K1chr1939106835-SUMF2chr756144527+0.0044900320.99551
ENST00000396857ENST00000434526MAP4K1chr1939106835-SUMF2chr756144527+0.0044685160.9955315

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Fusion Genomic Features for MAP4K1-SUMF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAP4K1-SUMF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39106835/chr7:56144527)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4K1

Q92918

.
FUNCTION: Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026). Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026). Able to autophosphorylate (PubMed:8824585). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity). {ECO:0000250|UniProtKB:P70218, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:8824585}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K1chr19:39106835chr7:56144527ENST00000396857-43123_31104822.0Nucleotide bindingATP
HgeneMAP4K1chr19:39106835chr7:56144527ENST00000591517-43223_31104834.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K1chr19:39106835chr7:56144527ENST00000396857-43117_274104822.0DomainProtein kinase
HgeneMAP4K1chr19:39106835chr7:56144527ENST00000396857-431495_800104822.0DomainCNH
HgeneMAP4K1chr19:39106835chr7:56144527ENST00000591517-43217_274104834.0DomainProtein kinase
HgeneMAP4K1chr19:39106835chr7:56144527ENST00000591517-432495_800104834.0DomainCNH


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Fusion Gene Sequence for MAP4K1-SUMF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51385_51385_1_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000396857_SUMF2_chr7_56144527_ENST00000275607_length(transcript)=1849nt_BP=421nt
GCGGAGGCAAGGCGGGTGCAGGGCTTCTGGGGACGGAGGGAGGTGCCAGAAGTTGAGCCCTGAGGCCCTGCTGGCCCCTGGGCGCAGGCC
CAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTGACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGT
GGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGAT
GATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTG
CAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTC
CAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCT
TTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGAC
ATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACT
CCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAA
GGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAA
CTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGC
CCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGG
AACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGT
TTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCG
TGTCCCTCTGAAGGAAACTAGTTTCCACTGTGTAACAGGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAGGGTCTGGGAGA
ACCAGATGATGTACTAGGTGAAGCATTGCATTGTGGGAATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAAGCTTCCTATTC
TTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTTCTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCACTCTAGCCTTGA
ATTCCTGGGCCCAAGCAATTCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTAATTTTTTGAAT
TTTTGTAGTGATGGGATCTCGCTCTGTTGCCCAGGGTGGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACCTCCCAAAGTGC
TGGGATTACAGGTGTGAGCCACCTCGCCTGGGCCCCCTTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCTGCTCCCACACT

>51385_51385_1_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000396857_SUMF2_chr7_56144527_ENST00000275607_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_2_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000396857_SUMF2_chr7_56144527_ENST00000395436_length(transcript)=1304nt_BP=421nt
GCGGAGGCAAGGCGGGTGCAGGGCTTCTGGGGACGGAGGGAGGTGCCAGAAGTTGAGCCCTGAGGCCCTGCTGGCCCCTGGGCGCAGGCC
CAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTGACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGT
GGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGAT
GATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTG
CAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTC
CAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCT
TTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGAC
ATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACT
CCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAA
GGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAA
CTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGC
CCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGG
AACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGT
TTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCG

>51385_51385_2_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000396857_SUMF2_chr7_56144527_ENST00000395436_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_3_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000396857_SUMF2_chr7_56144527_ENST00000434526_length(transcript)=1850nt_BP=421nt
GCGGAGGCAAGGCGGGTGCAGGGCTTCTGGGGACGGAGGGAGGTGCCAGAAGTTGAGCCCTGAGGCCCTGCTGGCCCCTGGGCGCAGGCC
CAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTGACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGT
GGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGAT
GATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTG
CAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTC
CAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCT
TTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGAC
ATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACT
CCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAA
GGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAA
CTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGC
CCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGG
AACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGT
TTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCG
TGTCCCTCTGAAGGAAACTAGTTTCCACTGTGTAACAGGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAGGGTCTGGGAGA
ACCAGATGATGTACTAGGTGAAGCATTGCATTGTGGGAATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAAGCTTCCTATTC
TTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTTCTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCACTCTAGCCTTGA
ATTCCTGGGCCCAAGCAATTCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTAATTTTTTGAAT
TTTTGTAGTGATGGGATCTCGCTCTGTTGCCCAGGGTGGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACCTCCCAAAGTGC
TGGGATTACAGGTGTGAGCCACCTCGCCTGGGCCCCCTTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCTGCTCCCACACT

>51385_51385_3_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000396857_SUMF2_chr7_56144527_ENST00000434526_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_4_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000586296_SUMF2_chr7_56144527_ENST00000275607_length(transcript)=1812nt_BP=384nt
GGGAGGTGCCAGAAGTTGAGCCCTGAGGCCCTGCTGGCCCCTGGGCGCAGGCCCAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTG
ACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGTGGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACA
AGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGATGATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGA
AAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTGCAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTG
GTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTCCAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCC
CCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCTTTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCC
TGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGACATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAG
CTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACTCCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTG
CTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGC
CATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAACTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGC
GCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGCCCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTT
CTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGGAACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTT
AAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGTTTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCA
GCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGTTTCCACTGTGTAACA
GGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAGGGTCTGGGAGAACCAGATGATGTACTAGGTGAAGCATTGCATTGTGGG
AATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAAGCTTCCTATTCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTT
CTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCACTCTAGCCTTGAATTCCTGGGCCCAAGCAATTCTCCCACCTCAGCCTCC
TGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTAATTTTTTGAATTTTTGTAGTGATGGGATCTCGCTCTGTTGCCCAGGGT
GGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCTCGCCTGGGCCCCC
TTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCTGCTCCCACACTGTCACTGGATGTCATGGGGCCAATAAAATCTCCTGCA

>51385_51385_4_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000586296_SUMF2_chr7_56144527_ENST00000275607_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_5_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000586296_SUMF2_chr7_56144527_ENST00000395436_length(transcript)=1267nt_BP=384nt
GGGAGGTGCCAGAAGTTGAGCCCTGAGGCCCTGCTGGCCCCTGGGCGCAGGCCCAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTG
ACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGTGGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACA
AGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGATGATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGA
AAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTGCAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTG
GTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTCCAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCC
CCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCTTTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCC
TGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGACATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAG
CTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACTCCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTG
CTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGC
CATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAACTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGC
GCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGCCCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTT
CTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGGAACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTT
AAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGTTTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCA
GCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGTTTCCACTGTGTAACA

>51385_51385_5_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000586296_SUMF2_chr7_56144527_ENST00000395436_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_6_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000586296_SUMF2_chr7_56144527_ENST00000434526_length(transcript)=1813nt_BP=384nt
GGGAGGTGCCAGAAGTTGAGCCCTGAGGCCCTGCTGGCCCCTGGGCGCAGGCCCAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTG
ACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGTGGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACA
AGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGATGATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGA
AAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTGCAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTG
GTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTCCAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCC
CCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCTTTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCC
TGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGACATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAG
CTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACTCCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTG
CTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGC
CATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAACTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGC
GCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGCCCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTT
CTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGGAACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTT
AAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGTTTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCA
GCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGTTTCCACTGTGTAACA
GGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAGGGTCTGGGAGAACCAGATGATGTACTAGGTGAAGCATTGCATTGTGGG
AATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAAGCTTCCTATTCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTT
CTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCACTCTAGCCTTGAATTCCTGGGCCCAAGCAATTCTCCCACCTCAGCCTCC
TGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTAATTTTTTGAATTTTTGTAGTGATGGGATCTCGCTCTGTTGCCCAGGGT
GGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCTCGCCTGGGCCCCC
TTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCTGCTCCCACACTGTCACTGGATGTCATGGGGCCAATAAAATCTCCTGCA

>51385_51385_6_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000586296_SUMF2_chr7_56144527_ENST00000434526_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_7_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000589130_SUMF2_chr7_56144527_ENST00000275607_length(transcript)=1827nt_BP=399nt
ACCCGGAGCTCTGGCGGCGTGCGCGCGCGTTGTATTGCGCGCGGCCATGAGGCCACGGAGCTCTGCGGGAATGCACGCAGCAGCCTTACG
TTTAGGCCATGGCCAAGTTCCGAGGGAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGTGGCGGCACGTATGGGGAAGTCT
TTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGATGATGTCTCCACCCTTCAGAAGG
AAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTGCAGAAACTCTGGATCTGCATGG
AATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTCCAGCCAAACCGCACCAACCTGT
GGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCTTTCCCCGCCCAGAACAACTACG
GGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGACATGCGCGTCCTCCGGGGGGCAT
CCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACTCCAGATTCAGCCTCAGACAACC
TCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCA
CTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAACTTCCCCTTCCCTGTCTCCCAT
CCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGCCCAATGTGTGTTGACGATGGCT
GGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGGAACAGAGCACTCTGAAAGGCCA
TTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGTTTCCTCAAGGCAGAATTTTCCT
GGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGT
TTCCACTGTGTAACAGGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAGGGTCTGGGAGAACCAGATGATGTACTAGGTGAA
GCATTGCATTGTGGGAATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAAGCTTCCTATTCTTTTTTTTTTTTTTTTTTTTTT
TGAGACAGGGTCTTTCTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCACTCTAGCCTTGAATTCCTGGGCCCAAGCAATTCT
CCCACCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTAATTTTTTGAATTTTTGTAGTGATGGGATCTCGC
TCTGTTGCCCAGGGTGGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCAC
CTCGCCTGGGCCCCCTTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCTGCTCCCACACTGTCACTGGATGTCATGGGGCCA

>51385_51385_7_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000589130_SUMF2_chr7_56144527_ENST00000275607_length(amino acids)=223AA_BP=100
MAKFRGRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFC
GAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRGASWI

--------------------------------------------------------------
>51385_51385_8_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000589130_SUMF2_chr7_56144527_ENST00000395436_length(transcript)=1282nt_BP=399nt
ACCCGGAGCTCTGGCGGCGTGCGCGCGCGTTGTATTGCGCGCGGCCATGAGGCCACGGAGCTCTGCGGGAATGCACGCAGCAGCCTTACG
TTTAGGCCATGGCCAAGTTCCGAGGGAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGTGGCGGCACGTATGGGGAAGTCT
TTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGATGATGTCTCCACCCTTCAGAAGG
AAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTGCAGAAACTCTGGATCTGCATGG
AATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTCCAGCCAAACCGCACCAACCTGT
GGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCTTTCCCCGCCCAGAACAACTACG
GGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGACATGCGCGTCCTCCGGGGGGCAT
CCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACTCCAGATTCAGCCTCAGACAACC
TCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCA
CTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAACTTCCCCTTCCCTGTCTCCCAT
CCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGCCCAATGTGTGTTGACGATGGCT
GGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGGAACAGAGCACTCTGAAAGGCCA
TTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGTTTCCTCAAGGCAGAATTTTCCT
GGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGT

>51385_51385_8_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000589130_SUMF2_chr7_56144527_ENST00000395436_length(amino acids)=223AA_BP=100
MAKFRGRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFC
GAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRGASWI

--------------------------------------------------------------
>51385_51385_9_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000589130_SUMF2_chr7_56144527_ENST00000434526_length(transcript)=1828nt_BP=399nt
ACCCGGAGCTCTGGCGGCGTGCGCGCGCGTTGTATTGCGCGCGGCCATGAGGCCACGGAGCTCTGCGGGAATGCACGCAGCAGCCTTACG
TTTAGGCCATGGCCAAGTTCCGAGGGAGAGACCCCCGGGACCACTATGACCTGCTACAGCGGCTGGGTGGCGGCACGTATGGGGAAGTCT
TTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGGAGCCTGATGATGATGTCTCCACCCTTCAGAAGG
AAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTTATCTCTGGTTGCAGAAACTCTGGATCTGCATGG
AATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGGGGAACTGGTTCCAGCCAAACCGCACCAACCTGT
GGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCCCAGTGAATGCTTTCCCCGCCCAGAACAACTACG
GGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAGGACATGCGCGTCCTCCGGGGGGCAT
CCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGATGGGCAACACTCCAGATTCAGCCTCAGACAACC
TCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCGGGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCA
CTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCCTCAGGAAAGAACTTCCCCTTCCCTGTCTCCCAT
CCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTTGGAGAAGGGGCCCAATGTGTGTTGACGATGGCT
GGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACACAAACAATTGGAACAGAGCACTCTGAAAGGCCA
TTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAAGCTGACATTGTTTCCTCAAGGCAGAATTTTCCT
GGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCATCTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGT
TTCCACTGTGTAACAGGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAGGGTCTGGGAGAACCAGATGATGTACTAGGTGAA
GCATTGCATTGTGGGAATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAAGCTTCCTATTCTTTTTTTTTTTTTTTTTTTTTT
TGAGACAGGGTCTTTCTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCACTCTAGCCTTGAATTCCTGGGCCCAAGCAATTCT
CCCACCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTAATTTTTTGAATTTTTGTAGTGATGGGATCTCGC
TCTGTTGCCCAGGGTGGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCAC
CTCGCCTGGGCCCCCTTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCTGCTCCCACACTGTCACTGGATGTCATGGGGCCA

>51385_51385_9_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000589130_SUMF2_chr7_56144527_ENST00000434526_length(amino acids)=223AA_BP=100
MAKFRGRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFC
GAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRGASWI

--------------------------------------------------------------
>51385_51385_10_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000591517_SUMF2_chr7_56144527_ENST00000275607_length(transcript)=1770nt_BP=342nt
GGGCGCAGGCCCAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTGACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTAC
AGCGGCTGGGTGGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGG
AGCCTGATGATGATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTT
ATCTCTGGTTGCAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGG
GGAACTGGTTCCAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCC
CAGTGAATGCTTTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTG
CTGAGCAGGACATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGA
TGGGCAACACTCCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCG
GGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCC
TCAGGAAAGAACTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTT
GGAGAAGGGGCCCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACA
CAAACAATTGGAACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAA
GCTGACATTGTTTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCAT
CTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGTTTCCACTGTGTAACAGGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAG
GGTCTGGGAGAACCAGATGATGTACTAGGTGAAGCATTGCATTGTGGGAATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAA
GCTTCCTATTCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTTCTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCAC
TCTAGCCTTGAATTCCTGGGCCCAAGCAATTCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTA
ATTTTTTGAATTTTTGTAGTGATGGGATCTCGCTCTGTTGCCCAGGGTGGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACC
TCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCTCGCCTGGGCCCCCTTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCT

>51385_51385_10_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000591517_SUMF2_chr7_56144527_ENST00000275607_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_11_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000591517_SUMF2_chr7_56144527_ENST00000395436_length(transcript)=1225nt_BP=342nt
GGGCGCAGGCCCAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTGACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTAC
AGCGGCTGGGTGGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGG
AGCCTGATGATGATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTT
ATCTCTGGTTGCAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGG
GGAACTGGTTCCAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCC
CAGTGAATGCTTTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTG
CTGAGCAGGACATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGA
TGGGCAACACTCCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCG
GGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCC
TCAGGAAAGAACTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTT
GGAGAAGGGGCCCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACA
CAAACAATTGGAACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAA
GCTGACATTGTTTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCAT

>51385_51385_11_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000591517_SUMF2_chr7_56144527_ENST00000395436_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------
>51385_51385_12_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000591517_SUMF2_chr7_56144527_ENST00000434526_length(transcript)=1771nt_BP=342nt
GGGCGCAGGCCCAGCTCAGGCCCCCAGGGATGGACGTCGTGGACCCTGACATTTTCAATAGAGACCCCCGGGACCACTATGACCTGCTAC
AGCGGCTGGGTGGCGGCACGTATGGGGAAGTCTTTAAGGCTCGAGACAAGGTGTCAGGGGACCTGGTGGCACTGAAGATGGTGAAGATGG
AGCCTGATGATGATGTCTCCACCCTTCAGAAGGAAATCCTCATATTGAAAACTTGCCGGCACGCCAACATCGTGGCCTACCATGGGAGTT
ATCTCTGGTTGCAGAAACTCTGGATCTGCATGGAATTCTGTGGGGCTGGTTCTCTCCAGGACATCTACCAAGGTCAAGTTTACCCATGGG
GGAACTGGTTCCAGCCAAACCGCACCAACCTGTGGCAGGGAAAGTTCCCCAAGGGAGACAAAGCTGAGGATGGCTTCCATGGAGTCTCCC
CAGTGAATGCTTTCCCCGCCCAGAACAACTACGGGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTG
CTGAGCAGGACATGCGCGTCCTCCGGGGGGCATCCTGGATCGACACAGCTGATGGCTCTGCCAATCACCGGGCCCGGGTCACCACCAGGA
TGGGCAACACTCCAGATTCAGCCTCAGACAACCTCGGTTTCCGCTGTGCTGCAGACGCAGGCCGGCCGCCAGGGGAGCTGTAAGCAGCCG
GGTGGTGACAAGGAGAAAAGCCTTCTAGGGTCACTGTCATTCCCTGGCCATGTTGCAAACAGCGCAATTCCAAGCTCGAGAGCTTCAGCC
TCAGGAAAGAACTTCCCCTTCCCTGTCTCCCATCCCTCTGTGGCAGGCGCCTCTCACCAGGGCAGGAGAGGACTCAGCCTCCTGTGTTTT
GGAGAAGGGGCCCAATGTGTGTTGACGATGGCTGGGGGCCAGGTGTTTCTGTTAGAGGCCAAGTATTATTGACACAGGATTGCAAACACA
CAAACAATTGGAACAGAGCACTCTGAAAGGCCATTTTTTAAGCATTTTAAAATCTATTCTCTCCCCCTTTCTCCCTGGATGATTCAGGAA
GCTGACATTGTTTCCTCAAGGCAGAATTTTCCTGGTTCTGTTTTCTCAGCCAGTTGCTGTGGAAGGAGAATGCTTTCTTTGTGGCCTCAT
CTGTGGTTTCGTGTCCCTCTGAAGGAAACTAGTTTCCACTGTGTAACAGGCAGACATGTAACTATTTAAAGCACAGTTCAGTCCTAAAAG
GGTCTGGGAGAACCAGATGATGTACTAGGTGAAGCATTGCATTGTGGGAATCACAAAGCAAATAGTACTCCAGAAAGACAAATATCAGAA
GCTTCCTATTCTTTTTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTTCTCTGTTGCCCAGGCTAGAGTGCACTGGTGATCACGGCTCAC
TCTAGCCTTGAATTCCTGGGCCCAAGCAATTCTCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAAGTGTGCACCACCATGCCTGGCTA
ATTTTTTGAATTTTTGTAGTGATGGGATCTCGCTCTGTTGCCCAGGGTGGTCTCGAACTCCTGGCCTCAAGCGATCCTCCCACCTCGACC
TCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCTCGCCTGGGCCCCCTTCTCCATATGCCTCCAAAAACATGTCCCTGGAGAGTAGCCT

>51385_51385_12_MAP4K1-SUMF2_MAP4K1_chr19_39106835_ENST00000591517_SUMF2_chr7_56144527_ENST00000434526_length(amino acids)=227AA_BP=104
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWIC
MEFCGAGSLQDIYQGQVYPWGNWFQPNRTNLWQGKFPKGDKAEDGFHGVSPVNAFPAQNNYGLYDLLGNVWEWTASPYQAAEQDMRVLRG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAP4K1-SUMF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4K1-SUMF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP4K1-SUMF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource