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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4K3-EML4 (FusionGDB2 ID:51390)

Fusion Gene Summary for MAP4K3-EML4

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K3-EML4
Fusion gene ID: 51390
HgeneTgene
Gene symbol

MAP4K3

EML4

Gene ID

8491

27436

Gene namemitogen-activated protein kinase kinase kinase kinase 3EMAP like 4
SynonymsGLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1C2orf2|ELP120|EMAP-4|EMAPL4|ROPP120
Cytomap

2p22.1

2p21

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinaseechinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120
Modification date2020031320200313
UniProtAcc

Q8IVH8

Q9HC35

Ensembl transtripts involved in fusion geneENST00000263881, ENST00000341681, 
ENST00000484274, ENST00000437545, 
ENST00000474502, ENST00000536018, 
ENST00000401738, ENST00000453191, 
ENST00000482660, ENST00000318522, 
ENST00000402711, 
Fusion gene scores* DoF score9 X 6 X 7=3789 X 10 X 6=540
# samples 1010
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4K3 [Title/Abstract] AND EML4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4K3(39605207)-EML4(42507990), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K3

GO:0006468

protein phosphorylation

9275185

HgeneMAP4K3

GO:0009411

response to UV

9275185

HgeneMAP4K3

GO:0034612

response to tumor necrosis factor

9275185

HgeneMAP4K3

GO:0035556

intracellular signal transduction

9275185


check buttonFusion gene breakpoints across MAP4K3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EML4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-QK-A8ZB-01AMAP4K3chr2

39605207

-EML4chr2

42507990

+


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Fusion Gene ORF analysis for MAP4K3-EML4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263881ENST00000401738MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000263881ENST00000453191MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000263881ENST00000482660MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000341681ENST00000401738MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000341681ENST00000453191MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000341681ENST00000482660MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000484274ENST00000401738MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000484274ENST00000453191MAP4K3chr2

39605207

-EML4chr2

42507990

+
5CDS-intronENST00000484274ENST00000482660MAP4K3chr2

39605207

-EML4chr2

42507990

+
5UTR-3CDSENST00000437545ENST00000318522MAP4K3chr2

39605207

-EML4chr2

42507990

+
5UTR-3CDSENST00000437545ENST00000402711MAP4K3chr2

39605207

-EML4chr2

42507990

+
5UTR-intronENST00000437545ENST00000401738MAP4K3chr2

39605207

-EML4chr2

42507990

+
5UTR-intronENST00000437545ENST00000453191MAP4K3chr2

39605207

-EML4chr2

42507990

+
5UTR-intronENST00000437545ENST00000482660MAP4K3chr2

39605207

-EML4chr2

42507990

+
In-frameENST00000263881ENST00000318522MAP4K3chr2

39605207

-EML4chr2

42507990

+
In-frameENST00000263881ENST00000402711MAP4K3chr2

39605207

-EML4chr2

42507990

+
In-frameENST00000341681ENST00000318522MAP4K3chr2

39605207

-EML4chr2

42507990

+
In-frameENST00000341681ENST00000402711MAP4K3chr2

39605207

-EML4chr2

42507990

+
In-frameENST00000484274ENST00000318522MAP4K3chr2

39605207

-EML4chr2

42507990

+
In-frameENST00000484274ENST00000402711MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-3CDSENST00000474502ENST00000318522MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-3CDSENST00000474502ENST00000402711MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-3CDSENST00000536018ENST00000318522MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-3CDSENST00000536018ENST00000402711MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-intronENST00000474502ENST00000401738MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-intronENST00000474502ENST00000453191MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-intronENST00000474502ENST00000482660MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-intronENST00000536018ENST00000401738MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-intronENST00000536018ENST00000453191MAP4K3chr2

39605207

-EML4chr2

42507990

+
intron-intronENST00000536018ENST00000482660MAP4K3chr2

39605207

-EML4chr2

42507990

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263881MAP4K3chr239605207-ENST00000318522EML4chr242507990+50994793132757814
ENST00000263881MAP4K3chr239605207-ENST00000402711EML4chr242507990+32954793132757814
ENST00000341681MAP4K3chr239605207-ENST00000318522EML4chr242507990+50884683022746814
ENST00000341681MAP4K3chr239605207-ENST00000402711EML4chr242507990+32844683022746814
ENST00000484274MAP4K3chr239605207-ENST00000318522EML4chr242507990+4852232662510814
ENST00000484274MAP4K3chr239605207-ENST00000402711EML4chr242507990+3048232662510814

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263881ENST00000318522MAP4K3chr239605207-EML4chr242507990+0.0002464820.99975353
ENST00000263881ENST00000402711MAP4K3chr239605207-EML4chr242507990+0.0005804060.99941957
ENST00000341681ENST00000318522MAP4K3chr239605207-EML4chr242507990+0.000250240.9997497
ENST00000341681ENST00000402711MAP4K3chr239605207-EML4chr242507990+0.0005846490.9994154
ENST00000484274ENST00000318522MAP4K3chr239605207-EML4chr242507990+0.0002347490.9997652
ENST00000484274ENST00000402711MAP4K3chr239605207-EML4chr242507990+0.0005941760.99940586

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Fusion Genomic Features for MAP4K3-EML4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAP4K3-EML4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39605207/chr2:42507990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4K3

Q8IVH8

EML4

Q9HC35

FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}.FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K3chr2:39605207chr2:42507990ENST00000263881-23422_3051895.0Nucleotide bindingATP
HgeneMAP4K3chr2:39605207chr2:42507990ENST00000341681-23322_3051874.0Nucleotide bindingATP
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523259_297222982.0RepeatNote=WD 1
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523301_348222982.0RepeatNote=WD 2
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523356_396222982.0RepeatNote=WD 3
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523403_438222982.0RepeatNote=WD 4
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523445_484222982.0RepeatNote=WD 5
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523500_538222982.0RepeatNote=WD 6
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523543_579222982.0RepeatNote=WD 7
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523582_621222982.0RepeatNote=WD 8
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523625_662222982.0RepeatNote=WD 9
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523668_704222982.0RepeatNote=WD 10
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523711_750222982.0RepeatNote=WD 11
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523760_818222982.0RepeatNote=WD 12
TgeneEML4chr2:39605207chr2:42507990ENST00000318522523825_864222982.0RepeatNote=WD 13
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422259_297164924.0RepeatNote=WD 1
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422301_348164924.0RepeatNote=WD 2
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422356_396164924.0RepeatNote=WD 3
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422403_438164924.0RepeatNote=WD 4
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422445_484164924.0RepeatNote=WD 5
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422500_538164924.0RepeatNote=WD 6
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422543_579164924.0RepeatNote=WD 7
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422582_621164924.0RepeatNote=WD 8
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422625_662164924.0RepeatNote=WD 9
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422668_704164924.0RepeatNote=WD 10
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422711_750164924.0RepeatNote=WD 11
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422760_818164924.0RepeatNote=WD 12
TgeneEML4chr2:39605207chr2:42507990ENST00000402711422825_864164924.0RepeatNote=WD 13

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K3chr2:39605207chr2:42507990ENST00000263881-23416_27351895.0DomainProtein kinase
HgeneMAP4K3chr2:39605207chr2:42507990ENST00000263881-234556_86751895.0DomainCNH
HgeneMAP4K3chr2:39605207chr2:42507990ENST00000341681-23316_27351874.0DomainProtein kinase
HgeneMAP4K3chr2:39605207chr2:42507990ENST00000341681-233556_86751874.0DomainCNH
TgeneEML4chr2:39605207chr2:42507990ENST000003185225231_249222982.0RegionMicrotubule-binding
TgeneEML4chr2:39605207chr2:42507990ENST000004027114221_249164924.0RegionMicrotubule-binding


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Fusion Gene Sequence for MAP4K3-EML4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51390_51390_1_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000263881_EML4_chr2_42507990_ENST00000318522_length(transcript)=5099nt_BP=479nt
AAGGGGAGGGGGAGGAGCGGCGAAAGCGGAAGCCATGTTGGAGTTTCACCCCGAGCGAGGGGCTGCGAGGGTTCTCCTCTCCTTGTGGGT
GTGACCAGGTTCGGCGCGGCGGCGGGCCGCGGGGGGCGGGGACGATTGGCCGCTTGTCGTCGTCCGCAGCGGCGTGAGGGGAGCGGCGGC
GGCGGCGGCGGCCGCAGCGTGGAGCCGGGTGATTGTGACCGCCGGGGGAGCCGGGAGCCGGCCGCGGCGCCCTCTCTCCGTGTGGCCCCC
TGAGCGGCCCCCCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGCTTCGATTTGTCCCGCCGGAACCC
GCAGGAGGACTTCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGGCACGGAATGTTAACACTGGTGAATTAGC
AGCAATTAAAGTAATAAAATTGGAACCAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTCCGA
TGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGGAAAGGACTGTAG
AGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGAGAGAACTCAGCG
ACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGATAGCTGGCGTGGA
TAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGCACTTTTGA
GCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCATATGCTTACTGT
ATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGCAAA
TACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAATTTTTGGGAAATA
TGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATGGAG
CAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGATGGCAGTGTGTT
CACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGA
AAGAGAAATAGAGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAGGAAAGGCAGATCAATTTTTAGTAGGCACATCACGAAA
CTTTATTTTACGAGGAACATTTAATGATGGCTTCCAAATAGAAGTACAGGGTCATACAGATGAGCTTTGGGGTCTTGCCACACATCCCTT
CAAAGATTTGCTCTTGACATGTGCTCAGGACAGGCAGGTGTGCCTGTGGAACTCAATGGAACACAGGCTGGAATGGACCAGGCTGGTAGA
TGAACCAGGACACTGTGCAGATTTTCATCCAAGTGGCACAGTGGTGGCCATAGGAACGCACTCAGGCAGGTGGTTTGTTCTGGATGCAGA
AACCAGAGATCTAGTTTCTATCCACACAGACGGGAATGAACAGCTCTCTGTGATGCGCTACTCAATAGATGGTACCTTCCTGGCTGTAGG
ATCTCATGACAACTTTATTTACCTCTATGTAGTCTCTGAAAATGGAAGAAAATATAGCAGATATGGAAGGTGCACTGGACATTCCAGCTA
CATCACACACCTTGACTGGTCCCCAGACAACAAGTATATAATGTCTAACTCGGGAGACTATGAAATATTGTACTGGGACATTCCAAATGG
CTGCAAACTAATCAGGAATCGATCGGATTGTAAGGACATTGATTGGACGACATATACCTGTGTGCTAGGATTTCAAGTATTTGGTGTCTG
GCCAGAAGGATCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGT
CCATCTGTTTCAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTAC
TCACAATGACAGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAA
TGAGACTGTAGCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTC
TCAGCCCTTAAATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCC
AAGTGAAGACCACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAA
GGAGCAGGCCAAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCA
GCTGCATGTGATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATT
TGTTTTCTTCAATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAA
TACTAGGAGAAGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAG
TTGCATTGATTTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCT
ACTGGCTCAGACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCC
AAATGTGTAATGGAAAATTTTTAATTAAGAAAAACTTCAGTTTTGCCAAGTGCAATGGTGTTGCCTTCTTTAAAAAATGCCGTTTTCTTA
CACTACCAGTGGATGTCCAGACATGCTCTTAGTCTACTAGAGAGGTGCTGCCTTTTCTAAGTCATAATGAGGAACAGTCCCTTAATTTCT
TGTGTGCAACTCTGTTTTATCCTAGAACTAAGAGAGCATTGGTTTGTTAAAGAGCTTTCAATGTATATTAAAACCTTCAATACTCAGAAA
TGATGGATTCCTCCAAGGAGTCCTTTACTAGCCTAAACATTCTCAAATGTTTGAGATTCAAGTGAATGGAAGGAAAACCACATGCCTTTA
AAACTAAACTGTAATAATTACCTGGCTAATTTCAGCTAAGCCTTCATCATAATTTGTTCCCTCAGTAATAGGAGAAATATAAATACAGTA
AGTTTAGATTATTGAATTGGTGCTTGAAATTTATTGGTTTTGTTGTAATTTTATACAGATTATATGAGGGATAAGATACTCATCAAATTG
CAAATTCTTTTTTTTACAGAAGTGTGGGTAACAGTCACAGCAGTTTTTTTTACCAACAGCATACTTAACAGACTTGCTGTGTAGCAGTTT
TTTTCTGGTGGAGTTGCTGTAAGTCTTGTAAGTCTAATGTGGCTATCCTACTCTTTTGGGCAATGCATGTATTATGCATTGGAAAGGTAT
TTTTTTTAAGTTCTGTTGGCTAGCTATGGTTTTCAGTACATTTCCTACTTTAAGAGTAATTACTGACAAATATGTATTTCCTATATGTTT
ATACTTTGATTATAAAAAAGTATTTTGTTTTGATTTTTTAACTTGCTGCATTGTTTTGATACTTTCTATTTTTTTGGTCAAATCATGTTT
AGAAACTTTGGATGAGTTAAGAAGTCTTAAGTATGCAGGCGTTTACGTGATTGTGCCATTCCAAAGTGCATCAGAACTGTCATTCCCTTC
TAATATCTTCTCAGGAGTAATACAAATCAGGTATTTCATCATCATTTGGTAATATGAAAACTCCAGTGAACTCCCAAGGACATTTACAAC
ATTTATATTCACACGCTGTATGGAAGGGTGTGGGTGTGTGTGAAGGGGCGAGTGGAGACACTGTGTGTATCTCTAGATAAGAAGATATGC
ACCACGTTGAAAATACTCAGTGTAGATCTCTATGTGTATAGGTATCTGTATATCTTTCCTTTTGTTTACAACTGTTAAAAAACCTCAAAA
TAGTTCTCTTCAAAAGAAGAGAGATTCCAAGCAACCCATCTTTCTTCAGTATGTATGTTCTGTACATACTTATCGGAGCGCGCCAGTAAG
TATCAGGCATATATATCTGTCTGTTAGCAATGATTATTACATCATCAGATCAGCATGTGCTATACTCCCTGCAAGAAATATACTGACATG
AACAGGCAGTTCTTGGAGAAGAAAGAGCATTTCTTTAAGTACCTGGGGAATACAGCTCTCAGTGATCAGCAGGGAGTTTATTTGAGGACA
TCAGTCACCTTTGGGGTTGCCATGTACAATGAGATTTATAATCATGATACTCTTCGGTGGTAGTTTCAAAAGACACTACTAATACGCAGG
AAGCGTTCCAGCTATTTAATGCTGGCAACTACTGTTTAATGGTCAGTTAAATCTGTGATAATGGTTGGAAGTGGGTGGGGTTATGAAATT
GTAGATGTTTTTAGAAAAACTTGTGAATGAAAATGAATCCAAGTGTTTCATGTGAAGATGTTGAGCCATTGCTATCATGCATTCCTGTCT

>51390_51390_1_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000263881_EML4_chr2_42507990_ENST00000318522_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------
>51390_51390_2_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000263881_EML4_chr2_42507990_ENST00000402711_length(transcript)=3295nt_BP=479nt
AAGGGGAGGGGGAGGAGCGGCGAAAGCGGAAGCCATGTTGGAGTTTCACCCCGAGCGAGGGGCTGCGAGGGTTCTCCTCTCCTTGTGGGT
GTGACCAGGTTCGGCGCGGCGGCGGGCCGCGGGGGGCGGGGACGATTGGCCGCTTGTCGTCGTCCGCAGCGGCGTGAGGGGAGCGGCGGC
GGCGGCGGCGGCCGCAGCGTGGAGCCGGGTGATTGTGACCGCCGGGGGAGCCGGGAGCCGGCCGCGGCGCCCTCTCTCCGTGTGGCCCCC
TGAGCGGCCCCCCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGCTTCGATTTGTCCCGCCGGAACCC
GCAGGAGGACTTCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGGCACGGAATGTTAACACTGGTGAATTAGC
AGCAATTAAAGTAATAAAATTGGAACCAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTCCGA
TGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGGAAAGGACTGTAG
AGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGAGAGAACTCAGCG
ACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGATAGCTGGCGTGGA
TAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGCACTTTTGA
GCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCATATGCTTACTGT
ATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGCAAA
TACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAATTTTTGGGAAATA
TGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATGGAG
CAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGATGGCAGTGTGTT
CACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGA
AAGAGAAATAGAGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAGGAAAGGCAGATCAATTTTTAGTAGGCACATCACGAAA
CTTTATTTTACGAGGAACATTTAATGATGGCTTCCAAATAGAAGTACAGGGTCATACAGATGAGCTTTGGGGTCTTGCCACACATCCCTT
CAAAGATTTGCTCTTGACATGTGCTCAGGACAGGCAGGTGTGCCTGTGGAACTCAATGGAACACAGGCTGGAATGGACCAGGCTGGTAGA
TGAACCAGGACACTGTGCAGATTTTCATCCAAGTGGCACAGTGGTGGCCATAGGAACGCACTCAGGCAGGTGGTTTGTTCTGGATGCAGA
AACCAGAGATCTAGTTTCTATCCACACAGACGGGAATGAACAGCTCTCTGTGATGCGCTACTCAATAGATGGTACCTTCCTGGCTGTAGG
ATCTCATGACAACTTTATTTACCTCTATGTAGTCTCTGAAAATGGAAGAAAATATAGCAGATATGGAAGGTGCACTGGACATTCCAGCTA
CATCACACACCTTGACTGGTCCCCAGACAACAAGTATATAATGTCTAACTCGGGAGACTATGAAATATTGTACTGGGACATTCCAAATGG
CTGCAAACTAATCAGGAATCGATCGGATTGTAAGGACATTGATTGGACGACATATACCTGTGTGCTAGGATTTCAAGTATTTGGTGTCTG
GCCAGAAGGATCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGT
CCATCTGTTTCAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTAC
TCACAATGACAGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAA
TGAGACTGTAGCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTC
TCAGCCCTTAAATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCC
AAGTGAAGACCACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAA
GGAGCAGGCCAAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCA
GCTGCATGTGATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATT
TGTTTTCTTCAATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAA
TACTAGGAGAAGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAG
TTGCATTGATTTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCT
ACTGGCTCAGACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCC

>51390_51390_2_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000263881_EML4_chr2_42507990_ENST00000402711_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------
>51390_51390_3_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000341681_EML4_chr2_42507990_ENST00000318522_length(transcript)=5088nt_BP=468nt
GAGGAGCGGCGAAAGCGGAAGCCATGTTGGAGTTTCACCCCGAGCGAGGGGCTGCGAGGGTTCTCCTCTCCTTGTGGGTGTGACCAGGTT
CGGCGCGGCGGCGGGCCGCGGGGGGCGGGGACGATTGGCCGCTTGTCGTCGTCCGCAGCGGCGTGAGGGGAGCGGCGGCGGCGGCGGCGG
CCGCAGCGTGGAGCCGGGTGATTGTGACCGCCGGGGGAGCCGGGAGCCGGCCGCGGCGCCCTCTCTCCGTGTGGCCCCCTGAGCGGCCCC
CCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGCTTCGATTTGTCCCGCCGGAACCCGCAGGAGGACT
TCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAG
TAATAAAATTGGAACCAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTCCGATGTTGACAACT
ATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGGAAAGGACTGTAGAGCTAATGTTT
ACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGAGAGAACTCAGCGACACTACCTGG
GCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGATAGCTGGCGTGGATAAAGATGGAA
GGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGCACTTTTGAGCGTGGAGTAG
GATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCATATGCTTACTGTATGGGACTGGC
AGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGCAAATACCATAATTA
CATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAATTTTTGGGAAATATGAAAAGCCAA
AATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATGGAGCAAAACTACTG
TAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGATGGCAGTGTGTTCACACTTTGTC
AGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGAAAGAGAAATAG
AGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAGGAAAGGCAGATCAATTTTTAGTAGGCACATCACGAAACTTTATTTTAC
GAGGAACATTTAATGATGGCTTCCAAATAGAAGTACAGGGTCATACAGATGAGCTTTGGGGTCTTGCCACACATCCCTTCAAAGATTTGC
TCTTGACATGTGCTCAGGACAGGCAGGTGTGCCTGTGGAACTCAATGGAACACAGGCTGGAATGGACCAGGCTGGTAGATGAACCAGGAC
ACTGTGCAGATTTTCATCCAAGTGGCACAGTGGTGGCCATAGGAACGCACTCAGGCAGGTGGTTTGTTCTGGATGCAGAAACCAGAGATC
TAGTTTCTATCCACACAGACGGGAATGAACAGCTCTCTGTGATGCGCTACTCAATAGATGGTACCTTCCTGGCTGTAGGATCTCATGACA
ACTTTATTTACCTCTATGTAGTCTCTGAAAATGGAAGAAAATATAGCAGATATGGAAGGTGCACTGGACATTCCAGCTACATCACACACC
TTGACTGGTCCCCAGACAACAAGTATATAATGTCTAACTCGGGAGACTATGAAATATTGTACTGGGACATTCCAAATGGCTGCAAACTAA
TCAGGAATCGATCGGATTGTAAGGACATTGATTGGACGACATATACCTGTGTGCTAGGATTTCAAGTATTTGGTGTCTGGCCAGAAGGAT
CTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGTCCATCTGTTTC
AGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTACTCACAATGACA
GTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAATGAGACTGTAG
CGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTCTCAGCCCTTAA
ATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCCAAGTGAAGACC
ACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAAGGAGCAGGCCA
AAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCAGCTGCATGTGA
TTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATTTGTTTTCTTCA
ATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAATACTAGGAGAA
GACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAGTTGCATTGATT
TTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCTACTGGCTCAGA
CTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCCAAATGTGTAAT
GGAAAATTTTTAATTAAGAAAAACTTCAGTTTTGCCAAGTGCAATGGTGTTGCCTTCTTTAAAAAATGCCGTTTTCTTACACTACCAGTG
GATGTCCAGACATGCTCTTAGTCTACTAGAGAGGTGCTGCCTTTTCTAAGTCATAATGAGGAACAGTCCCTTAATTTCTTGTGTGCAACT
CTGTTTTATCCTAGAACTAAGAGAGCATTGGTTTGTTAAAGAGCTTTCAATGTATATTAAAACCTTCAATACTCAGAAATGATGGATTCC
TCCAAGGAGTCCTTTACTAGCCTAAACATTCTCAAATGTTTGAGATTCAAGTGAATGGAAGGAAAACCACATGCCTTTAAAACTAAACTG
TAATAATTACCTGGCTAATTTCAGCTAAGCCTTCATCATAATTTGTTCCCTCAGTAATAGGAGAAATATAAATACAGTAAGTTTAGATTA
TTGAATTGGTGCTTGAAATTTATTGGTTTTGTTGTAATTTTATACAGATTATATGAGGGATAAGATACTCATCAAATTGCAAATTCTTTT
TTTTACAGAAGTGTGGGTAACAGTCACAGCAGTTTTTTTTACCAACAGCATACTTAACAGACTTGCTGTGTAGCAGTTTTTTTCTGGTGG
AGTTGCTGTAAGTCTTGTAAGTCTAATGTGGCTATCCTACTCTTTTGGGCAATGCATGTATTATGCATTGGAAAGGTATTTTTTTTAAGT
TCTGTTGGCTAGCTATGGTTTTCAGTACATTTCCTACTTTAAGAGTAATTACTGACAAATATGTATTTCCTATATGTTTATACTTTGATT
ATAAAAAAGTATTTTGTTTTGATTTTTTAACTTGCTGCATTGTTTTGATACTTTCTATTTTTTTGGTCAAATCATGTTTAGAAACTTTGG
ATGAGTTAAGAAGTCTTAAGTATGCAGGCGTTTACGTGATTGTGCCATTCCAAAGTGCATCAGAACTGTCATTCCCTTCTAATATCTTCT
CAGGAGTAATACAAATCAGGTATTTCATCATCATTTGGTAATATGAAAACTCCAGTGAACTCCCAAGGACATTTACAACATTTATATTCA
CACGCTGTATGGAAGGGTGTGGGTGTGTGTGAAGGGGCGAGTGGAGACACTGTGTGTATCTCTAGATAAGAAGATATGCACCACGTTGAA
AATACTCAGTGTAGATCTCTATGTGTATAGGTATCTGTATATCTTTCCTTTTGTTTACAACTGTTAAAAAACCTCAAAATAGTTCTCTTC
AAAAGAAGAGAGATTCCAAGCAACCCATCTTTCTTCAGTATGTATGTTCTGTACATACTTATCGGAGCGCGCCAGTAAGTATCAGGCATA
TATATCTGTCTGTTAGCAATGATTATTACATCATCAGATCAGCATGTGCTATACTCCCTGCAAGAAATATACTGACATGAACAGGCAGTT
CTTGGAGAAGAAAGAGCATTTCTTTAAGTACCTGGGGAATACAGCTCTCAGTGATCAGCAGGGAGTTTATTTGAGGACATCAGTCACCTT
TGGGGTTGCCATGTACAATGAGATTTATAATCATGATACTCTTCGGTGGTAGTTTCAAAAGACACTACTAATACGCAGGAAGCGTTCCAG
CTATTTAATGCTGGCAACTACTGTTTAATGGTCAGTTAAATCTGTGATAATGGTTGGAAGTGGGTGGGGTTATGAAATTGTAGATGTTTT
TAGAAAAACTTGTGAATGAAAATGAATCCAAGTGTTTCATGTGAAGATGTTGAGCCATTGCTATCATGCATTCCTGTCTCATGGCAGAAA

>51390_51390_3_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000341681_EML4_chr2_42507990_ENST00000318522_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------
>51390_51390_4_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000341681_EML4_chr2_42507990_ENST00000402711_length(transcript)=3284nt_BP=468nt
GAGGAGCGGCGAAAGCGGAAGCCATGTTGGAGTTTCACCCCGAGCGAGGGGCTGCGAGGGTTCTCCTCTCCTTGTGGGTGTGACCAGGTT
CGGCGCGGCGGCGGGCCGCGGGGGGCGGGGACGATTGGCCGCTTGTCGTCGTCCGCAGCGGCGTGAGGGGAGCGGCGGCGGCGGCGGCGG
CCGCAGCGTGGAGCCGGGTGATTGTGACCGCCGGGGGAGCCGGGAGCCGGCCGCGGCGCCCTCTCTCCGTGTGGCCCCCTGAGCGGCCCC
CCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGCTTCGATTTGTCCCGCCGGAACCCGCAGGAGGACT
TCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGGCACGGAATGTTAACACTGGTGAATTAGCAGCAATTAAAG
TAATAAAATTGGAACCAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCAATTACCATGTTCATTCCTTCCGATGTTGACAACT
ATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATATGGTTATCGAGGAAAGGACTGTAGAGCTAATGTTT
ACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTTAATTATGAGGAGAGAACTCAGCGACACTACCTGG
GCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCAACTGGACAGATAGCTGGCGTGGATAAAGATGGAA
GGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAGATTATTGGACTTGGCACTTTTGAGCGTGGAGTAG
GATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGACTCCAATGAGCATATGCTTACTGTATGGGACTGGC
AGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGCAAATACCATAATTA
CATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGGAATTTTTGGGAAATATGAAAAGCCAA
AATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTATATGGAGCAAAACTACTG
TAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATCAAAGCTCATGATGGCAGTGTGTTCACACTTTGTC
AGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTGTGGGATCATGATCTGAATCCTGAAAGAGAAATAG
AGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAGGAAAGGCAGATCAATTTTTAGTAGGCACATCACGAAACTTTATTTTAC
GAGGAACATTTAATGATGGCTTCCAAATAGAAGTACAGGGTCATACAGATGAGCTTTGGGGTCTTGCCACACATCCCTTCAAAGATTTGC
TCTTGACATGTGCTCAGGACAGGCAGGTGTGCCTGTGGAACTCAATGGAACACAGGCTGGAATGGACCAGGCTGGTAGATGAACCAGGAC
ACTGTGCAGATTTTCATCCAAGTGGCACAGTGGTGGCCATAGGAACGCACTCAGGCAGGTGGTTTGTTCTGGATGCAGAAACCAGAGATC
TAGTTTCTATCCACACAGACGGGAATGAACAGCTCTCTGTGATGCGCTACTCAATAGATGGTACCTTCCTGGCTGTAGGATCTCATGACA
ACTTTATTTACCTCTATGTAGTCTCTGAAAATGGAAGAAAATATAGCAGATATGGAAGGTGCACTGGACATTCCAGCTACATCACACACC
TTGACTGGTCCCCAGACAACAAGTATATAATGTCTAACTCGGGAGACTATGAAATATTGTACTGGGACATTCCAAATGGCTGCAAACTAA
TCAGGAATCGATCGGATTGTAAGGACATTGATTGGACGACATATACCTGTGTGCTAGGATTTCAAGTATTTGGTGTCTGGCCAGAAGGAT
CTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCTGTTGCCGATGACTTTTGTAAAGTCCATCTGTTTC
AGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGCCATGTCACCAATGTCAGTTTTACTCACAATGACA
GTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTGGAAAAGTTATCTTTGCCTCAGAATGAGACTGTAG
CGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCTAATACTCCCACACCGCCTCCTTCTCAGCCCTTAA
ATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAACAGCCTGGAACAAACTGTGGAGCCAAGTGAAGACC
ACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAAGAGCCATGCAACGAGATAAGCAAGGAGCAGGCCA
AAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGCTTCAGTGCAACTCTTTTCCTTCAGCTGCATGTGA
TTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATTGAGATTTTGGTTTCCATGTGATTTGTTTTCTTCA
ATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTTTATTGAAAATTAACCAAACTTAATACTAGGAGAA
GACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTAAATACTGGAAACAAAAACAGCAGTTGCATTGATT
TTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGTATCACAAACACTGTTACTCATCTACTGGCTCAGA
CTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTCTTACTGAGATACCCTCTCACCCCAAATGTGTAAT

>51390_51390_4_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000341681_EML4_chr2_42507990_ENST00000402711_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------
>51390_51390_5_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000484274_EML4_chr2_42507990_ENST00000318522_length(transcript)=4852nt_BP=232nt
CGCCCTCTCTCCGTGTGGCCCCCTGAGCGGCCCCCCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGC
TTCGATTTGTCCCGCCGGAACCCGCAGGAGGACTTCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGGCACGG
AATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCA
ATTACCATGTTCATTCCTTCCGATGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATAT
GGTTATCGAGGAAAGGACTGTAGAGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTT
AATTATGAGGAGAGAACTCAGCGACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCA
ACTGGACAGATAGCTGGCGTGGATAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAG
ATTATTGGACTTGGCACTTTTGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGAC
TCCAATGAGCATATGCTTACTGTATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTG
GAGTTTCACCCAACAGATGCAAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGA
AAACAGGGAATTTTTGGGAAATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCA
GGTGGAGTCATGCTTATATGGAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATC
AAAGCTCATGATGGCAGTGTGTTCACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTG
TGGGATCATGATCTGAATCCTGAAAGAGAAATAGAGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAGGAAAGGCAGATCAA
TTTTTAGTAGGCACATCACGAAACTTTATTTTACGAGGAACATTTAATGATGGCTTCCAAATAGAAGTACAGGGTCATACAGATGAGCTT
TGGGGTCTTGCCACACATCCCTTCAAAGATTTGCTCTTGACATGTGCTCAGGACAGGCAGGTGTGCCTGTGGAACTCAATGGAACACAGG
CTGGAATGGACCAGGCTGGTAGATGAACCAGGACACTGTGCAGATTTTCATCCAAGTGGCACAGTGGTGGCCATAGGAACGCACTCAGGC
AGGTGGTTTGTTCTGGATGCAGAAACCAGAGATCTAGTTTCTATCCACACAGACGGGAATGAACAGCTCTCTGTGATGCGCTACTCAATA
GATGGTACCTTCCTGGCTGTAGGATCTCATGACAACTTTATTTACCTCTATGTAGTCTCTGAAAATGGAAGAAAATATAGCAGATATGGA
AGGTGCACTGGACATTCCAGCTACATCACACACCTTGACTGGTCCCCAGACAACAAGTATATAATGTCTAACTCGGGAGACTATGAAATA
TTGTACTGGGACATTCCAAATGGCTGCAAACTAATCAGGAATCGATCGGATTGTAAGGACATTGATTGGACGACATATACCTGTGTGCTA
GGATTTCAAGTATTTGGTGTCTGGCCAGAAGGATCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCT
GTTGCCGATGACTTTTGTAAAGTCCATCTGTTTCAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGC
CATGTCACCAATGTCAGTTTTACTCACAATGACAGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTG
GAAAAGTTATCTTTGCCTCAGAATGAGACTGTAGCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCT
AATACTCCCACACCGCCTCCTTCTCAGCCCTTAAATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAAC
AGCCTGGAACAAACTGTGGAGCCAAGTGAAGACCACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAA
GAGCCATGCAACGAGATAAGCAAGGAGCAGGCCAAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGC
TTCAGTGCAACTCTTTTCCTTCAGCTGCATGTGATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATT
GAGATTTTGGTTTCCATGTGATTTGTTTTCTTCAATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTT
TATTGAAAATTAACCAAACTTAATACTAGGAGAAGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTA
AATACTGGAAACAAAAACAGCAGTTGCATTGATTTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGT
ATCACAAACACTGTTACTCATCTACTGGCTCAGACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTC
TTACTGAGATACCCTCTCACCCCAAATGTGTAATGGAAAATTTTTAATTAAGAAAAACTTCAGTTTTGCCAAGTGCAATGGTGTTGCCTT
CTTTAAAAAATGCCGTTTTCTTACACTACCAGTGGATGTCCAGACATGCTCTTAGTCTACTAGAGAGGTGCTGCCTTTTCTAAGTCATAA
TGAGGAACAGTCCCTTAATTTCTTGTGTGCAACTCTGTTTTATCCTAGAACTAAGAGAGCATTGGTTTGTTAAAGAGCTTTCAATGTATA
TTAAAACCTTCAATACTCAGAAATGATGGATTCCTCCAAGGAGTCCTTTACTAGCCTAAACATTCTCAAATGTTTGAGATTCAAGTGAAT
GGAAGGAAAACCACATGCCTTTAAAACTAAACTGTAATAATTACCTGGCTAATTTCAGCTAAGCCTTCATCATAATTTGTTCCCTCAGTA
ATAGGAGAAATATAAATACAGTAAGTTTAGATTATTGAATTGGTGCTTGAAATTTATTGGTTTTGTTGTAATTTTATACAGATTATATGA
GGGATAAGATACTCATCAAATTGCAAATTCTTTTTTTTACAGAAGTGTGGGTAACAGTCACAGCAGTTTTTTTTACCAACAGCATACTTA
ACAGACTTGCTGTGTAGCAGTTTTTTTCTGGTGGAGTTGCTGTAAGTCTTGTAAGTCTAATGTGGCTATCCTACTCTTTTGGGCAATGCA
TGTATTATGCATTGGAAAGGTATTTTTTTTAAGTTCTGTTGGCTAGCTATGGTTTTCAGTACATTTCCTACTTTAAGAGTAATTACTGAC
AAATATGTATTTCCTATATGTTTATACTTTGATTATAAAAAAGTATTTTGTTTTGATTTTTTAACTTGCTGCATTGTTTTGATACTTTCT
ATTTTTTTGGTCAAATCATGTTTAGAAACTTTGGATGAGTTAAGAAGTCTTAAGTATGCAGGCGTTTACGTGATTGTGCCATTCCAAAGT
GCATCAGAACTGTCATTCCCTTCTAATATCTTCTCAGGAGTAATACAAATCAGGTATTTCATCATCATTTGGTAATATGAAAACTCCAGT
GAACTCCCAAGGACATTTACAACATTTATATTCACACGCTGTATGGAAGGGTGTGGGTGTGTGTGAAGGGGCGAGTGGAGACACTGTGTG
TATCTCTAGATAAGAAGATATGCACCACGTTGAAAATACTCAGTGTAGATCTCTATGTGTATAGGTATCTGTATATCTTTCCTTTTGTTT
ACAACTGTTAAAAAACCTCAAAATAGTTCTCTTCAAAAGAAGAGAGATTCCAAGCAACCCATCTTTCTTCAGTATGTATGTTCTGTACAT
ACTTATCGGAGCGCGCCAGTAAGTATCAGGCATATATATCTGTCTGTTAGCAATGATTATTACATCATCAGATCAGCATGTGCTATACTC
CCTGCAAGAAATATACTGACATGAACAGGCAGTTCTTGGAGAAGAAAGAGCATTTCTTTAAGTACCTGGGGAATACAGCTCTCAGTGATC
AGCAGGGAGTTTATTTGAGGACATCAGTCACCTTTGGGGTTGCCATGTACAATGAGATTTATAATCATGATACTCTTCGGTGGTAGTTTC
AAAAGACACTACTAATACGCAGGAAGCGTTCCAGCTATTTAATGCTGGCAACTACTGTTTAATGGTCAGTTAAATCTGTGATAATGGTTG
GAAGTGGGTGGGGTTATGAAATTGTAGATGTTTTTAGAAAAACTTGTGAATGAAAATGAATCCAAGTGTTTCATGTGAAGATGTTGAGCC

>51390_51390_5_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000484274_EML4_chr2_42507990_ENST00000318522_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------
>51390_51390_6_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000484274_EML4_chr2_42507990_ENST00000402711_length(transcript)=3048nt_BP=232nt
CGCCCTCTCTCCGTGTGGCCCCCTGAGCGGCCCCCCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGC
TTCGATTTGTCCCGCCGGAACCCGCAGGAGGACTTCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGGCACGG
AATGTTAACACTGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGAAGGAGAATATATTAAAATGTTTATGCGCGGTCGGCCA
ATTACCATGTTCATTCCTTCCGATGTTGACAACTATGATGACATCAGAACGGAACTGCCTCCTGAGAAGCTCAAACTGGAGTGGGCATAT
GGTTATCGAGGAAAGGACTGTAGAGCTAATGTTTACCTTCTTCCGACCGGGAAAATAGTTTATTTCATTGCATCAGTAGTAGTACTATTT
AATTATGAGGAGAGAACTCAGCGACACTACCTGGGCCATACAGACTGTGTGAAATGCCTTGCTATACATCCTGACAAAATTAGGATTGCA
ACTGGACAGATAGCTGGCGTGGATAAAGATGGAAGGCCTCTACAACCCCACGTCAGAGTGTGGGATTCTGTTACTCTATCCACACTGCAG
ATTATTGGACTTGGCACTTTTGAGCGTGGAGTAGGATGCCTGGATTTTTCAAAAGCAGATTCAGGTGTTCATTTATGTATTATTGATGAC
TCCAATGAGCATATGCTTACTGTATGGGACTGGCAGAAGAAAGCAAAAGGAGCAGAAATAAAGACAACAAATGAAGTTGTTTTGGCTGTG
GAGTTTCACCCAACAGATGCAAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGA
AAACAGGGAATTTTTGGGAAATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCA
GGTGGAGTCATGCTTATATGGAGCAAAACTACTGTAGAGCCCACACCTGGGAAAGGACCTAAAGGTGTATATCAAATCAGCAAACAAATC
AAAGCTCATGATGGCAGTGTGTTCACACTTTGTCAGATGAGAAATGGGATGTTATTAACTGGAGGAGGGAAAGACAGAAAAATAATTCTG
TGGGATCATGATCTGAATCCTGAAAGAGAAATAGAGGTTCCTGATCAGTATGGCACAATCAGAGCTGTAGCAGAAGGAAAGGCAGATCAA
TTTTTAGTAGGCACATCACGAAACTTTATTTTACGAGGAACATTTAATGATGGCTTCCAAATAGAAGTACAGGGTCATACAGATGAGCTT
TGGGGTCTTGCCACACATCCCTTCAAAGATTTGCTCTTGACATGTGCTCAGGACAGGCAGGTGTGCCTGTGGAACTCAATGGAACACAGG
CTGGAATGGACCAGGCTGGTAGATGAACCAGGACACTGTGCAGATTTTCATCCAAGTGGCACAGTGGTGGCCATAGGAACGCACTCAGGC
AGGTGGTTTGTTCTGGATGCAGAAACCAGAGATCTAGTTTCTATCCACACAGACGGGAATGAACAGCTCTCTGTGATGCGCTACTCAATA
GATGGTACCTTCCTGGCTGTAGGATCTCATGACAACTTTATTTACCTCTATGTAGTCTCTGAAAATGGAAGAAAATATAGCAGATATGGA
AGGTGCACTGGACATTCCAGCTACATCACACACCTTGACTGGTCCCCAGACAACAAGTATATAATGTCTAACTCGGGAGACTATGAAATA
TTGTACTGGGACATTCCAAATGGCTGCAAACTAATCAGGAATCGATCGGATTGTAAGGACATTGATTGGACGACATATACCTGTGTGCTA
GGATTTCAAGTATTTGGTGTCTGGCCAGAAGGATCTGATGGGACAGATATCAATGCACTGGTGCGATCCCACAATAGAAAGGTGATAGCT
GTTGCCGATGACTTTTGTAAAGTCCATCTGTTTCAGTATCCCTGCTCCAAAGCAAAGGCTCCCAGTCACAAGTACAGTGCCCACAGCAGC
CATGTCACCAATGTCAGTTTTACTCACAATGACAGTCACCTGATATCAACTGGTGGAAAAGACATGAGCATCATTCAGTGGAAACTTGTG
GAAAAGTTATCTTTGCCTCAGAATGAGACTGTAGCGGATACTACTCTAACCAAAGCCCCCGTCTCTTCCACTGAAAGTGTCATCCAATCT
AATACTCCCACACCGCCTCCTTCTCAGCCCTTAAATGAGACAGCTGAAGAGGAAAGTAGAATAAGCAGTTCTCCCACACTTCTGGAGAAC
AGCCTGGAACAAACTGTGGAGCCAAGTGAAGACCACAGCGAGGAGGAGAGTGAAGAGGGCAGCGGAGACCTTGGTGAGCCTCTTTATGAA
GAGCCATGCAACGAGATAAGCAAGGAGCAGGCCAAAGCCACCCTTCTGGAGGACCAGCAAGACCCTTCGCCCTCGTCCTAACACCCTGGC
TTCAGTGCAACTCTTTTCCTTCAGCTGCATGTGATTTTGTGATAAAGTTCAGGTAACAGGATGGGCAGTGATGGAGAATCACTGTTGATT
GAGATTTTGGTTTCCATGTGATTTGTTTTCTTCAATAGTCTTATTTTCAGTCTCTCAAATACAGCCAACTTAAAGTTTTAGTTTGGTGTT
TATTGAAAATTAACCAAACTTAATACTAGGAGAAGACTGAATCATTAATGATGTCTCACAAATTACTGTGTACCTAAGTGGTGTGATGTA
AATACTGGAAACAAAAACAGCAGTTGCATTGATTTTGAAAACAAACCCCCTTGTTATCTGAACATGTTTTCTTCAGGAACAACCAGAGGT
ATCACAAACACTGTTACTCATCTACTGGCTCAGACTGTACTACTTTTTTTTTTTTTTTTCCTGAAAAAGAAACCAGAAAAAAATGTACTC

>51390_51390_6_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000484274_EML4_chr2_42507990_ENST00000402711_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAP4K3-EML4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4K3-EML4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP4K3-EML4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource