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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MAP4K3-SRGAP2 (FusionGDB2 ID:51398) |
Fusion Gene Summary for MAP4K3-SRGAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP4K3-SRGAP2 | Fusion gene ID: 51398 | Hgene | Tgene | Gene symbol | MAP4K3 | SRGAP2 | Gene ID | 8491 | 23380 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 3 | SLIT-ROBO Rho GTPase activating protein 2 | |
| Synonyms | GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1 | ARHGAP34|FNBP2|SRGAP2A|SRGAP3 | |
| Cytomap | 2p22.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase | SLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8IVH8 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000263881, ENST00000341681, ENST00000484274, ENST00000437545, ENST00000474502, ENST00000536018, | ENST00000471256, ENST00000419187, ENST00000414007, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 15 X 15 X 7=1575 |
| # samples | 10 | 16 | |
| ** MAII score | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1575*10)=-3.29920801838728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAP4K3 [Title/Abstract] AND SRGAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MAP4K3(39664033)-SRGAP2(206557369), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MAP4K3-SRGAP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MAP4K3-SRGAP2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K3 | GO:0006468 | protein phosphorylation | 9275185 |
| Hgene | MAP4K3 | GO:0009411 | response to UV | 9275185 |
| Hgene | MAP4K3 | GO:0034612 | response to tumor necrosis factor | 9275185 |
| Hgene | MAP4K3 | GO:0035556 | intracellular signal transduction | 9275185 |
| Tgene | SRGAP2 | GO:0043547 | positive regulation of GTPase activity | 21148482 |
| Tgene | SRGAP2 | GO:0046847 | filopodium assembly | 22559944 |
| Tgene | SRGAP2 | GO:0051014 | actin filament severing | 21148482 |
| Tgene | SRGAP2 | GO:0060996 | dendritic spine development | 22559944 |
| Tgene | SRGAP2 | GO:2001223 | negative regulation of neuron migration | 22559944 |
| Fusion gene breakpoints across MAP4K3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SRGAP2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-V1-A8MJ-01A | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| ChimerDB4 | PRAD | TCGA-V1-A8MJ | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
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Fusion Gene ORF analysis for MAP4K3-SRGAP2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000263881 | ENST00000471256 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| 5CDS-intron | ENST00000341681 | ENST00000471256 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| 5CDS-intron | ENST00000484274 | ENST00000471256 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| Frame-shift | ENST00000263881 | ENST00000419187 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| Frame-shift | ENST00000341681 | ENST00000419187 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| Frame-shift | ENST00000484274 | ENST00000419187 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| In-frame | ENST00000263881 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| In-frame | ENST00000341681 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| In-frame | ENST00000484274 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-3CDS | ENST00000437545 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-3CDS | ENST00000437545 | ENST00000419187 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-3CDS | ENST00000474502 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-3CDS | ENST00000474502 | ENST00000419187 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-3CDS | ENST00000536018 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-3CDS | ENST00000536018 | ENST00000419187 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-intron | ENST00000437545 | ENST00000471256 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-intron | ENST00000474502 | ENST00000471256 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| intron-intron | ENST00000536018 | ENST00000471256 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000263881 | MAP4K3 | chr2 | 39664033 | - | ENST00000414007 | SRGAP2 | chr1 | 206557369 | + | 6235 | 421 | 313 | 3216 | 967 |
| ENST00000341681 | MAP4K3 | chr2 | 39664033 | - | ENST00000414007 | SRGAP2 | chr1 | 206557369 | + | 6224 | 410 | 302 | 3205 | 967 |
| ENST00000484274 | MAP4K3 | chr2 | 39664033 | - | ENST00000414007 | SRGAP2 | chr1 | 206557369 | + | 5988 | 174 | 66 | 2969 | 967 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000263881 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + | 0.000312687 | 0.9996873 |
| ENST00000341681 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + | 0.000318669 | 0.99968135 |
| ENST00000484274 | ENST00000414007 | MAP4K3 | chr2 | 39664033 | - | SRGAP2 | chr1 | 206557369 | + | 0.00032914 | 0.99967086 |
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Fusion Genomic Features for MAP4K3-SRGAP2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAP4K3-SRGAP2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39664033/chr1:206557369) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K3 | . |
| FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP4K3 | chr2:39664033 | chr1:206557369 | ENST00000263881 | - | 1 | 34 | 22_30 | 32 | 895.0 | Nucleotide binding | ATP |
| Hgene | MAP4K3 | chr2:39664033 | chr1:206557369 | ENST00000341681 | - | 1 | 33 | 22_30 | 32 | 874.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP4K3 | chr2:39664033 | chr1:206557369 | ENST00000263881 | - | 1 | 34 | 16_273 | 32 | 895.0 | Domain | Protein kinase |
| Hgene | MAP4K3 | chr2:39664033 | chr1:206557369 | ENST00000263881 | - | 1 | 34 | 556_867 | 32 | 895.0 | Domain | CNH |
| Hgene | MAP4K3 | chr2:39664033 | chr1:206557369 | ENST00000341681 | - | 1 | 33 | 16_273 | 32 | 874.0 | Domain | Protein kinase |
| Hgene | MAP4K3 | chr2:39664033 | chr1:206557369 | ENST00000341681 | - | 1 | 33 | 556_867 | 32 | 874.0 | Domain | CNH |
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Fusion Gene Sequence for MAP4K3-SRGAP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >51398_51398_1_MAP4K3-SRGAP2_MAP4K3_chr2_39664033_ENST00000263881_SRGAP2_chr1_206557369_ENST00000414007_length(transcript)=6235nt_BP=421nt AAGGGGAGGGGGAGGAGCGGCGAAAGCGGAAGCCATGTTGGAGTTTCACCCCGAGCGAGGGGCTGCGAGGGTTCTCCTCTCCTTGTGGGT GTGACCAGGTTCGGCGCGGCGGCGGGCCGCGGGGGGCGGGGACGATTGGCCGCTTGTCGTCGTCCGCAGCGGCGTGAGGGGAGCGGCGGC GGCGGCGGCGGCCGCAGCGTGGAGCCGGGTGATTGTGACCGCCGGGGGAGCCGGGAGCCGGCCGCGGCGCCCTCTCTCCGTGTGGCCCCC TGAGCGGCCCCCCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGCTTCGATTTGTCCCGCCGGAACCC GCAGGAGGACTTCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGCAGAGTAAAGAAGTCGGCCAGCAGCTCCA AGATGATTTGATGAAGGTCCTGAACGAGCTCTACTCGGTGATGAAGACATATCACATGTACAATGCCGACAGCATCAGTGCTCAGAGCAA ACTAAAGGAGGCGGAGAAGCAGGAGGAGAAGCAAATTGGTAAATCGGTAAAGCAGGAGGACCGGCAGACCCCACGCTCCCCTGACTCCAC GGCCAACGTTCGCATTGAGGAGAAACATGTCCGGAGGAGCTCAGTGAAGAAGATTGAGAAGATGAAGGAGAAGCGTCAAGCCAAGTACAC GGAGAATAAGCTGAAGGCCATCAAAGCCCGGAATGAGTACTTGCTGGCTTTGGAGGCAACCAATGCATCTGTCTTCAAGTACTACATCCA TGACCTATCTGACCTTATTGATCAGTGTTGTGACTTAGGCTACCATGCAAGTCTGAACCGGGCTCTACGCACCTTCCTCTCTGCTGAGTT AAACCTGGAACAGTCGAAGCATGAGGGTCTGGATGCCATCGAGAATGCAGTAGAAAACCTGGATGCCACCAGTGACAAGCAGCGCCTCAT GGAGATGTACAACAACGTCTTCTGCCCCCCTATGAAGTTTGAGTTTCAGCCCCACATGGGGGATATGGCTTCCCAGCTCTGTGCCCAGCA GCCTGTCCAGAGTGAGCTGGTACAGAGATGCCAACAACTGCAGTCTCGCTTATCCACTCTAAAGATTGAAAACGAAGAGGTAAAGAAGAC AATGGAGGCCACCCTGCAAACCATCCAGGACATTGTGACTGTCGAGGACTTTGATGTGTCTGACTGCTTCCAGTACAGCAACTCCATGGA GTCCGTCAAGTCCACGGTCTCTGAAACCTTCATGAGCAAGCCCAGCATTGCTAAGAGGAGAGCCAACCAGCAAGAGACAGAGCAGTTTTA TTTCACAAAAATGAAAGAGTACCTGGAGGGCAGGAACCTCATCACCAAGTTACAAGCCAAGCATGACCTTCTGCAGAAAACCCTGGGAGA AAGTCAGCGGACAGATTGCAGTCTAGCCAGGCGCAGCTCAACTGTGAGGAAACAGGACTCCAGCCAGGCAATTCCTCTGGTGGTGGAAAG CTGTATCCGGTTTATCAGCAGACACGGACTACAGCATGAAGGAATTTTCCGGGTGTCAGGATCCCAGGTGGAAGTGAATGACATCAAAAA TGCCTTTGAGAGAGGAGAGGACCCCCTGGCTGGGGACCAGAACGACCATGACATGGATTCCATAGCTGGTGTCCTGAAGCTTTACTTCCG GGGGCTGGAACACCCTCTCTTCCCCAAGGACATCTTTCATGACCTGATGGCCTGCGTCACAATGGACAACCTGCAGGAGAGAGCTCTGCA CATCCGGAAAGTCCTCCTAGTCCTGCCCAAAACCACTCTGATTATCATGAGATACCTCTTTGCCTTCCTCAATCATTTATCACAGTTCAG TGAAGAGAACATGATGGACCCCTACAACCTCGCCATCTGCTTCGGGCCCTCGCTAATGTCAGTGCCAGAGGGCCACGACCAGGTGTCCTG CCAAGCCCACGTGAATGAGCTGATCAAAACCATCATCATCCAGCATGAGAACATCTTCCCAAGCCCCAGGGAGCTGGAGGGCCCTGTCTA CAGCAGAGGAGGAAGCATGGAGGATTACTGTGATAGCCCTCATGGAGAGACTACCTCGGTTGAAGACTCAACCCAGGATGTGACCGCAGA GCACCACACGAGCGATGACGAATGTGAGCCCATCGAGGCCATTGCCAAGTTTGACTACGTGGGCCGGACAGCCCGAGAGCTGTCCTTTAA GAAGGGAGCATCCCTGCTGCTTTACCAGCGGGCTTCCGACGACTGGTGGGAAGGCCGGCACAATGGCATCGACGGACTCATCCCCCATCA GTACATCGTGGTCCAAGACACCGAGGACGGTGTCGTGGAGAGGTCCAGCCCCAAGTCTGAGATTGAGGTCATTTCTGAGCCACCTGAAGA AAAGGTGACAGCCAGAGCGGGGGCCAGCTGTCCCAGTGGGGGTCATGTAGCCGATATTTATCTTGCAAACATCAACAAGCAAAGGAAGCG TCCAGAATCTGGGAGCATCCGGAAAACTTTTCGGAGTGACAGCCATGGGCTGAGCAGTTCCCTGACTGACTCCTCCTCCCCAGGGGTGGG GGCTAGCTGCCGCCCATCCTCCCAGCCCATCATGAGCCAGAGCCTCCCCAAAGAAGGGCCAGATAAGTGTTCCATCAGTGGGCACGGGAG CCTCAACTCCATCAGCCGCCACTCATCCCTGAAGAATCGGCTGGATAGTCCACAGATCCGGAAGACTGCCACAGCGGGAAGGTCAAAAAG CTTCAATAACCATCGGCCCATGGACCCTGAGGTCATTGCTCAGGATATTGAGGCAACAATGAACTCGGCCCTGAATGAGCTACGGGAACT AGAACGGCAGAGCAGTGTCAAACACACCCCTGACGTGGTTCTGGACACCTTGGAGCCCCTCAAAACCTCCCCAGTGGTGGCCCCCACGTC AGAGCCCTCCAGCCCTCTGCACACCCAGCTCCTCAAGGACCCCGAGCCCGCCTTCCAGCGCAGCGCCAGTACTGCTGGGGACATCGCCTG CGCCTTCCGGCCTGTCAAGTCTGTCAAGATGGCTGCCCCGGTCAAACCACCAGCCACACGGCCCAAGCCCACTGTCTTCCCCAAAACAAA TGCCACTAGCCCTGGTGTCAACTCATCAACTTCCCCACAGTCTACTGACAAGTCTTGTACTGTCTGAGGGATAATAATTTAATTGTTCTA GACAAGGGGACTATAGGGACTGACTGTTATTAAAATCTTCCTATTTAACTAGCTTGGGGACTTCAGTTGAAAATTAGGTTCTAAGTTGTT CTTGCAGGAATTAGCCTCCCCGTCTCCCAAAACCTTGAGAATGAAGCCCTTGGTATCGCCTCTCCCTTCCCACTGCCCTCTGCTTCCCCC AGTCGTCGTAATTCAGCCAGCTGCAGTCCGTACCGTTCTTAGGTTAGCCAGAGACAGGTTTTCATTATCAGGTCACTGTGAAATCTGGTA AGGCAGTCCTGAGGACATGGGCTCAAGTCTCAGTCCCCTCAGACCACGGTGATGCCTTGACCAGATGGTTGGCTACTGCCATCCAGCTTT CAGTGGCATCTTGTTTTGGGAACTGATTATAGAGAATCATATATAGTCCAGTCTTCATTTTACATACACACACATATTTTACACACACAC ACATTTTACACACACACACACACACACACACATATGTTTTTCTAGTCTCTGGCATGTGTAGCCTCTCCTGGTCATAGACCAGTCTCTTTG TAAGTTATTGTGGCAGTTCACACAGTAGCCACCAGGGGTCTCTGTTTCCATTACAAACTTTGTTCTGTCTGGGCCAGAGAACCTAGCCTT TGAAATCTCTCCATCATATGAAACATAACGGGATGGGACAATCCCGTAACCTGTTTGGGGTTGGGGGCTTTCTCTCTGTGTTCTTTCCAT TGATGTGAATTGGTCATTGGTGTTTGCTCTTGCCTCTCCTCCATCCCCTAGAAGTACACCCCCGTCTTATTAAGGAGCTTTTAAAGTTTT TCTGAATGTATAGACATTTCTCGGGTTCCTACCTTTGTCTCTGATGGACCATTTTCCATTTAAGACATTTTCCTGTATAAGACAGTTTTA TAGCTGGTTCCTTTTAGGGTAAAGAGTCTTAAGAGAGTTTTATTGTGTCTATGGCAGGTTTGGGAAAGGTAAGAAATGGGTCCTTTTTCC TCCTAATGTTTTTGGCACTTAAAACATAAAATTCATTATCCTATTAAAAAATTAAATTCAGCTTTGCTAATCCAGAAATTGTTCCCAAAT GAAAACTTGTTTTAAGTCCACCCCTTAGTTTCCTTATTTTACAAGGTCTCTCTTCAGGGACCAACAGGGGCTTAGAGAGCCTTAGTTAGA TTAAAGGGAGACCCTACCTCTTAAAACCAGTTTTCATTTATGCAAACAAGGACAATTAAGGGAACCCTGACCCCACAGGCTCTCAAGTCT TCCCAAGGCCAGAATCGAAAGAAAATTAAAATTTGAATGCTGAATATTCTGGCTCTACTCTGGCCTTTTTTCTGGTTCCCTTCCAAAATG CACAAATCATACCCTTGTCTGCTCCAATTCAGTCTCCAAACCTGGTGCCTGTGCTCCTGGCCCCCCTAGCATCATGCTATCCCAGGAGTA TCAGGACCAGACACATCCACAGCCAGGCTCATGGGTCTCAGACAGCAACTTGAGTTAAAGCTGAAACTCATCCTTCTTCTCTGTGTTTTC TGGTTTAAAAGCTGCACTTATATTTTAGCCTTATTATTTTCTGTAGTTCCGGAGAGATGGTGGGTTGCCATTCTGGTAGGAAAATCTGAG TTTTCTTATCTTTGACCTAGAAGAGATTCTTTTTGGACCAACCTGCGAAATTGGTAGTTAGGTCTATGGAAAGTGGTAGGATTTTTTTTT TTTAATCCTGTGCAAAGGAAAAGAGGTGCTTTGTGGGAAATCACTAATGAGAAGGCTAACCTGCAGCACCAGAGAAACCTTTCCAAGTGC TAGGCAGGAGAACTGAAGAACTCTTTCAGTGAAGTGAGTCAGCCTAGAAGAGGCAACCCACAGTCTTGATTTTTGTTGCTGTTTCCTGAC CTGTTCTTGCCTGTCACCTGGGCCTACACAGGTCCCGAGCCAACGGGGCTTTCATACCCAAGGATCTGTTTCCTTGCTGAAAATGAAACC CTATCTTTCACTTTACATTCCTTTCAATCCAACTGATCAAAACTGGTACCCACACTTGCCCTTTCTCCCTCTCTCCAGCACACTCCCCTC TAAGAAAGTAAAAGCAAAGCTTTCTTAATGGCAACACTTTGGGCCTGTTCTGTTGCTCCTGCCTTATTTCTCTTTCAACCCTGTACATGA CTCGTGTTCACCATCCCCTTGATCAGTGTCCATCCGCGCTAATTTGCATCATGAACTGAACAGTGTGTGAGTGGTCACCTACTAAACCCA GCTCTGGGGGCAGAGCTGTCTTCCCCATCTCTGGTGCTCCTAACACCTGTGAGATGGTCCTGTCGAGAGGACTAGGAACCGATAGGAGGA GAGTCCTTCTCGGCAGAGCTCACTGCAAACAACTGGAATTGAGGTTGCACACTGTGATTTTTACACCGAAAAGCCAAAAGGAGCTGGCCA TCCAGGGCCTAGGGAGACCAGCCTTCCTCAGCTATGCTTGCCGAAACCAGCATGATGCTTCAAAGAGCCCTGCTCCACCCCTCATGGCAT GGATCCTTTTCCTGGTGTGGACTCTGAAGGGTCAGTCTTCGGGGAAGAGAGGTGGGGTGGGGCTACTAGCATCCCAATTTAGAAAACAGA GGAGTTTGTAGCCAGCAGCCTGTAAACTGGAAACACTGGTCTCAGCCAACCTCCTCAGGGCGCCCTGGCTTCTCCCCAAGGAGATGAGGA GCGGTGATGCCAGCACCGGGATGCGCAGAGCACTGGAAGGGCTGGTGCAGATCTACTTCCCATGCAGAAGAGAAGTCACATCTTCCAGGG AATCGCAATGTTGTGGCGTCTGACTTGTATGTCACATTTGTGTAAAATGGTATATTCTTTAAAATAGTGTTGATAACTGGAATATTGTAT GTATGCTTGGAGATGCTTTGTGTGAACCTAAGACTGTCACTCAACAGATGTTGGATTGGGGAAAATCCAAAGCACAACTTCAAAATAAAA >51398_51398_1_MAP4K3-SRGAP2_MAP4K3_chr2_39664033_ENST00000263881_SRGAP2_chr1_206557369_ENST00000414007_length(amino acids)=967AA_BP=36 MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKQSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGK SVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGY HASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQ SRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLI TKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQN DHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICF GPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAI AKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGG HVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRL DSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDP -------------------------------------------------------------- >51398_51398_2_MAP4K3-SRGAP2_MAP4K3_chr2_39664033_ENST00000341681_SRGAP2_chr1_206557369_ENST00000414007_length(transcript)=6224nt_BP=410nt GAGGAGCGGCGAAAGCGGAAGCCATGTTGGAGTTTCACCCCGAGCGAGGGGCTGCGAGGGTTCTCCTCTCCTTGTGGGTGTGACCAGGTT CGGCGCGGCGGCGGGCCGCGGGGGGCGGGGACGATTGGCCGCTTGTCGTCGTCCGCAGCGGCGTGAGGGGAGCGGCGGCGGCGGCGGCGG CCGCAGCGTGGAGCCGGGTGATTGTGACCGCCGGGGGAGCCGGGAGCCGGCCGCGGCGCCCTCTCTCCGTGTGGCCCCCTGAGCGGCCCC CCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGCTTCGATTTGTCCCGCCGGAACCCGCAGGAGGACT TCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGCAGAGTAAAGAAGTCGGCCAGCAGCTCCAAGATGATTTGA TGAAGGTCCTGAACGAGCTCTACTCGGTGATGAAGACATATCACATGTACAATGCCGACAGCATCAGTGCTCAGAGCAAACTAAAGGAGG CGGAGAAGCAGGAGGAGAAGCAAATTGGTAAATCGGTAAAGCAGGAGGACCGGCAGACCCCACGCTCCCCTGACTCCACGGCCAACGTTC GCATTGAGGAGAAACATGTCCGGAGGAGCTCAGTGAAGAAGATTGAGAAGATGAAGGAGAAGCGTCAAGCCAAGTACACGGAGAATAAGC TGAAGGCCATCAAAGCCCGGAATGAGTACTTGCTGGCTTTGGAGGCAACCAATGCATCTGTCTTCAAGTACTACATCCATGACCTATCTG ACCTTATTGATCAGTGTTGTGACTTAGGCTACCATGCAAGTCTGAACCGGGCTCTACGCACCTTCCTCTCTGCTGAGTTAAACCTGGAAC AGTCGAAGCATGAGGGTCTGGATGCCATCGAGAATGCAGTAGAAAACCTGGATGCCACCAGTGACAAGCAGCGCCTCATGGAGATGTACA ACAACGTCTTCTGCCCCCCTATGAAGTTTGAGTTTCAGCCCCACATGGGGGATATGGCTTCCCAGCTCTGTGCCCAGCAGCCTGTCCAGA GTGAGCTGGTACAGAGATGCCAACAACTGCAGTCTCGCTTATCCACTCTAAAGATTGAAAACGAAGAGGTAAAGAAGACAATGGAGGCCA CCCTGCAAACCATCCAGGACATTGTGACTGTCGAGGACTTTGATGTGTCTGACTGCTTCCAGTACAGCAACTCCATGGAGTCCGTCAAGT CCACGGTCTCTGAAACCTTCATGAGCAAGCCCAGCATTGCTAAGAGGAGAGCCAACCAGCAAGAGACAGAGCAGTTTTATTTCACAAAAA TGAAAGAGTACCTGGAGGGCAGGAACCTCATCACCAAGTTACAAGCCAAGCATGACCTTCTGCAGAAAACCCTGGGAGAAAGTCAGCGGA CAGATTGCAGTCTAGCCAGGCGCAGCTCAACTGTGAGGAAACAGGACTCCAGCCAGGCAATTCCTCTGGTGGTGGAAAGCTGTATCCGGT TTATCAGCAGACACGGACTACAGCATGAAGGAATTTTCCGGGTGTCAGGATCCCAGGTGGAAGTGAATGACATCAAAAATGCCTTTGAGA GAGGAGAGGACCCCCTGGCTGGGGACCAGAACGACCATGACATGGATTCCATAGCTGGTGTCCTGAAGCTTTACTTCCGGGGGCTGGAAC ACCCTCTCTTCCCCAAGGACATCTTTCATGACCTGATGGCCTGCGTCACAATGGACAACCTGCAGGAGAGAGCTCTGCACATCCGGAAAG TCCTCCTAGTCCTGCCCAAAACCACTCTGATTATCATGAGATACCTCTTTGCCTTCCTCAATCATTTATCACAGTTCAGTGAAGAGAACA TGATGGACCCCTACAACCTCGCCATCTGCTTCGGGCCCTCGCTAATGTCAGTGCCAGAGGGCCACGACCAGGTGTCCTGCCAAGCCCACG TGAATGAGCTGATCAAAACCATCATCATCCAGCATGAGAACATCTTCCCAAGCCCCAGGGAGCTGGAGGGCCCTGTCTACAGCAGAGGAG GAAGCATGGAGGATTACTGTGATAGCCCTCATGGAGAGACTACCTCGGTTGAAGACTCAACCCAGGATGTGACCGCAGAGCACCACACGA GCGATGACGAATGTGAGCCCATCGAGGCCATTGCCAAGTTTGACTACGTGGGCCGGACAGCCCGAGAGCTGTCCTTTAAGAAGGGAGCAT CCCTGCTGCTTTACCAGCGGGCTTCCGACGACTGGTGGGAAGGCCGGCACAATGGCATCGACGGACTCATCCCCCATCAGTACATCGTGG TCCAAGACACCGAGGACGGTGTCGTGGAGAGGTCCAGCCCCAAGTCTGAGATTGAGGTCATTTCTGAGCCACCTGAAGAAAAGGTGACAG CCAGAGCGGGGGCCAGCTGTCCCAGTGGGGGTCATGTAGCCGATATTTATCTTGCAAACATCAACAAGCAAAGGAAGCGTCCAGAATCTG GGAGCATCCGGAAAACTTTTCGGAGTGACAGCCATGGGCTGAGCAGTTCCCTGACTGACTCCTCCTCCCCAGGGGTGGGGGCTAGCTGCC GCCCATCCTCCCAGCCCATCATGAGCCAGAGCCTCCCCAAAGAAGGGCCAGATAAGTGTTCCATCAGTGGGCACGGGAGCCTCAACTCCA TCAGCCGCCACTCATCCCTGAAGAATCGGCTGGATAGTCCACAGATCCGGAAGACTGCCACAGCGGGAAGGTCAAAAAGCTTCAATAACC ATCGGCCCATGGACCCTGAGGTCATTGCTCAGGATATTGAGGCAACAATGAACTCGGCCCTGAATGAGCTACGGGAACTAGAACGGCAGA GCAGTGTCAAACACACCCCTGACGTGGTTCTGGACACCTTGGAGCCCCTCAAAACCTCCCCAGTGGTGGCCCCCACGTCAGAGCCCTCCA GCCCTCTGCACACCCAGCTCCTCAAGGACCCCGAGCCCGCCTTCCAGCGCAGCGCCAGTACTGCTGGGGACATCGCCTGCGCCTTCCGGC CTGTCAAGTCTGTCAAGATGGCTGCCCCGGTCAAACCACCAGCCACACGGCCCAAGCCCACTGTCTTCCCCAAAACAAATGCCACTAGCC CTGGTGTCAACTCATCAACTTCCCCACAGTCTACTGACAAGTCTTGTACTGTCTGAGGGATAATAATTTAATTGTTCTAGACAAGGGGAC TATAGGGACTGACTGTTATTAAAATCTTCCTATTTAACTAGCTTGGGGACTTCAGTTGAAAATTAGGTTCTAAGTTGTTCTTGCAGGAAT TAGCCTCCCCGTCTCCCAAAACCTTGAGAATGAAGCCCTTGGTATCGCCTCTCCCTTCCCACTGCCCTCTGCTTCCCCCAGTCGTCGTAA TTCAGCCAGCTGCAGTCCGTACCGTTCTTAGGTTAGCCAGAGACAGGTTTTCATTATCAGGTCACTGTGAAATCTGGTAAGGCAGTCCTG AGGACATGGGCTCAAGTCTCAGTCCCCTCAGACCACGGTGATGCCTTGACCAGATGGTTGGCTACTGCCATCCAGCTTTCAGTGGCATCT TGTTTTGGGAACTGATTATAGAGAATCATATATAGTCCAGTCTTCATTTTACATACACACACATATTTTACACACACACACATTTTACAC ACACACACACACACACACACATATGTTTTTCTAGTCTCTGGCATGTGTAGCCTCTCCTGGTCATAGACCAGTCTCTTTGTAAGTTATTGT GGCAGTTCACACAGTAGCCACCAGGGGTCTCTGTTTCCATTACAAACTTTGTTCTGTCTGGGCCAGAGAACCTAGCCTTTGAAATCTCTC CATCATATGAAACATAACGGGATGGGACAATCCCGTAACCTGTTTGGGGTTGGGGGCTTTCTCTCTGTGTTCTTTCCATTGATGTGAATT GGTCATTGGTGTTTGCTCTTGCCTCTCCTCCATCCCCTAGAAGTACACCCCCGTCTTATTAAGGAGCTTTTAAAGTTTTTCTGAATGTAT AGACATTTCTCGGGTTCCTACCTTTGTCTCTGATGGACCATTTTCCATTTAAGACATTTTCCTGTATAAGACAGTTTTATAGCTGGTTCC TTTTAGGGTAAAGAGTCTTAAGAGAGTTTTATTGTGTCTATGGCAGGTTTGGGAAAGGTAAGAAATGGGTCCTTTTTCCTCCTAATGTTT TTGGCACTTAAAACATAAAATTCATTATCCTATTAAAAAATTAAATTCAGCTTTGCTAATCCAGAAATTGTTCCCAAATGAAAACTTGTT TTAAGTCCACCCCTTAGTTTCCTTATTTTACAAGGTCTCTCTTCAGGGACCAACAGGGGCTTAGAGAGCCTTAGTTAGATTAAAGGGAGA CCCTACCTCTTAAAACCAGTTTTCATTTATGCAAACAAGGACAATTAAGGGAACCCTGACCCCACAGGCTCTCAAGTCTTCCCAAGGCCA GAATCGAAAGAAAATTAAAATTTGAATGCTGAATATTCTGGCTCTACTCTGGCCTTTTTTCTGGTTCCCTTCCAAAATGCACAAATCATA CCCTTGTCTGCTCCAATTCAGTCTCCAAACCTGGTGCCTGTGCTCCTGGCCCCCCTAGCATCATGCTATCCCAGGAGTATCAGGACCAGA CACATCCACAGCCAGGCTCATGGGTCTCAGACAGCAACTTGAGTTAAAGCTGAAACTCATCCTTCTTCTCTGTGTTTTCTGGTTTAAAAG CTGCACTTATATTTTAGCCTTATTATTTTCTGTAGTTCCGGAGAGATGGTGGGTTGCCATTCTGGTAGGAAAATCTGAGTTTTCTTATCT TTGACCTAGAAGAGATTCTTTTTGGACCAACCTGCGAAATTGGTAGTTAGGTCTATGGAAAGTGGTAGGATTTTTTTTTTTTAATCCTGT GCAAAGGAAAAGAGGTGCTTTGTGGGAAATCACTAATGAGAAGGCTAACCTGCAGCACCAGAGAAACCTTTCCAAGTGCTAGGCAGGAGA ACTGAAGAACTCTTTCAGTGAAGTGAGTCAGCCTAGAAGAGGCAACCCACAGTCTTGATTTTTGTTGCTGTTTCCTGACCTGTTCTTGCC TGTCACCTGGGCCTACACAGGTCCCGAGCCAACGGGGCTTTCATACCCAAGGATCTGTTTCCTTGCTGAAAATGAAACCCTATCTTTCAC TTTACATTCCTTTCAATCCAACTGATCAAAACTGGTACCCACACTTGCCCTTTCTCCCTCTCTCCAGCACACTCCCCTCTAAGAAAGTAA AAGCAAAGCTTTCTTAATGGCAACACTTTGGGCCTGTTCTGTTGCTCCTGCCTTATTTCTCTTTCAACCCTGTACATGACTCGTGTTCAC CATCCCCTTGATCAGTGTCCATCCGCGCTAATTTGCATCATGAACTGAACAGTGTGTGAGTGGTCACCTACTAAACCCAGCTCTGGGGGC AGAGCTGTCTTCCCCATCTCTGGTGCTCCTAACACCTGTGAGATGGTCCTGTCGAGAGGACTAGGAACCGATAGGAGGAGAGTCCTTCTC GGCAGAGCTCACTGCAAACAACTGGAATTGAGGTTGCACACTGTGATTTTTACACCGAAAAGCCAAAAGGAGCTGGCCATCCAGGGCCTA GGGAGACCAGCCTTCCTCAGCTATGCTTGCCGAAACCAGCATGATGCTTCAAAGAGCCCTGCTCCACCCCTCATGGCATGGATCCTTTTC CTGGTGTGGACTCTGAAGGGTCAGTCTTCGGGGAAGAGAGGTGGGGTGGGGCTACTAGCATCCCAATTTAGAAAACAGAGGAGTTTGTAG CCAGCAGCCTGTAAACTGGAAACACTGGTCTCAGCCAACCTCCTCAGGGCGCCCTGGCTTCTCCCCAAGGAGATGAGGAGCGGTGATGCC AGCACCGGGATGCGCAGAGCACTGGAAGGGCTGGTGCAGATCTACTTCCCATGCAGAAGAGAAGTCACATCTTCCAGGGAATCGCAATGT TGTGGCGTCTGACTTGTATGTCACATTTGTGTAAAATGGTATATTCTTTAAAATAGTGTTGATAACTGGAATATTGTATGTATGCTTGGA GATGCTTTGTGTGAACCTAAGACTGTCACTCAACAGATGTTGGATTGGGGAAAATCCAAAGCACAACTTCAAAATAAAATACATTTTTAG >51398_51398_2_MAP4K3-SRGAP2_MAP4K3_chr2_39664033_ENST00000341681_SRGAP2_chr1_206557369_ENST00000414007_length(amino acids)=967AA_BP=36 MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKQSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGK SVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGY HASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQ SRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLI TKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQN DHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICF GPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAI AKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGG HVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRL DSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDP -------------------------------------------------------------- >51398_51398_3_MAP4K3-SRGAP2_MAP4K3_chr2_39664033_ENST00000484274_SRGAP2_chr1_206557369_ENST00000414007_length(transcript)=5988nt_BP=174nt CGCCCTCTCTCCGTGTGGCCCCCTGAGCGGCCCCCCTCCCCTGCCCGGGAGGGAGGCGGGGGGCACCTGGGGCCCGCCATGAACCCCGGC TTCGATTTGTCCCGCCGGAACCCGCAGGAGGACTTCGAGCTGATTCAGCGCATCGGCAGCGGCACCTACGGCGACGTCTACAAGCAGAGT AAAGAAGTCGGCCAGCAGCTCCAAGATGATTTGATGAAGGTCCTGAACGAGCTCTACTCGGTGATGAAGACATATCACATGTACAATGCC GACAGCATCAGTGCTCAGAGCAAACTAAAGGAGGCGGAGAAGCAGGAGGAGAAGCAAATTGGTAAATCGGTAAAGCAGGAGGACCGGCAG ACCCCACGCTCCCCTGACTCCACGGCCAACGTTCGCATTGAGGAGAAACATGTCCGGAGGAGCTCAGTGAAGAAGATTGAGAAGATGAAG GAGAAGCGTCAAGCCAAGTACACGGAGAATAAGCTGAAGGCCATCAAAGCCCGGAATGAGTACTTGCTGGCTTTGGAGGCAACCAATGCA TCTGTCTTCAAGTACTACATCCATGACCTATCTGACCTTATTGATCAGTGTTGTGACTTAGGCTACCATGCAAGTCTGAACCGGGCTCTA CGCACCTTCCTCTCTGCTGAGTTAAACCTGGAACAGTCGAAGCATGAGGGTCTGGATGCCATCGAGAATGCAGTAGAAAACCTGGATGCC ACCAGTGACAAGCAGCGCCTCATGGAGATGTACAACAACGTCTTCTGCCCCCCTATGAAGTTTGAGTTTCAGCCCCACATGGGGGATATG GCTTCCCAGCTCTGTGCCCAGCAGCCTGTCCAGAGTGAGCTGGTACAGAGATGCCAACAACTGCAGTCTCGCTTATCCACTCTAAAGATT GAAAACGAAGAGGTAAAGAAGACAATGGAGGCCACCCTGCAAACCATCCAGGACATTGTGACTGTCGAGGACTTTGATGTGTCTGACTGC TTCCAGTACAGCAACTCCATGGAGTCCGTCAAGTCCACGGTCTCTGAAACCTTCATGAGCAAGCCCAGCATTGCTAAGAGGAGAGCCAAC CAGCAAGAGACAGAGCAGTTTTATTTCACAAAAATGAAAGAGTACCTGGAGGGCAGGAACCTCATCACCAAGTTACAAGCCAAGCATGAC CTTCTGCAGAAAACCCTGGGAGAAAGTCAGCGGACAGATTGCAGTCTAGCCAGGCGCAGCTCAACTGTGAGGAAACAGGACTCCAGCCAG GCAATTCCTCTGGTGGTGGAAAGCTGTATCCGGTTTATCAGCAGACACGGACTACAGCATGAAGGAATTTTCCGGGTGTCAGGATCCCAG GTGGAAGTGAATGACATCAAAAATGCCTTTGAGAGAGGAGAGGACCCCCTGGCTGGGGACCAGAACGACCATGACATGGATTCCATAGCT GGTGTCCTGAAGCTTTACTTCCGGGGGCTGGAACACCCTCTCTTCCCCAAGGACATCTTTCATGACCTGATGGCCTGCGTCACAATGGAC AACCTGCAGGAGAGAGCTCTGCACATCCGGAAAGTCCTCCTAGTCCTGCCCAAAACCACTCTGATTATCATGAGATACCTCTTTGCCTTC CTCAATCATTTATCACAGTTCAGTGAAGAGAACATGATGGACCCCTACAACCTCGCCATCTGCTTCGGGCCCTCGCTAATGTCAGTGCCA GAGGGCCACGACCAGGTGTCCTGCCAAGCCCACGTGAATGAGCTGATCAAAACCATCATCATCCAGCATGAGAACATCTTCCCAAGCCCC AGGGAGCTGGAGGGCCCTGTCTACAGCAGAGGAGGAAGCATGGAGGATTACTGTGATAGCCCTCATGGAGAGACTACCTCGGTTGAAGAC TCAACCCAGGATGTGACCGCAGAGCACCACACGAGCGATGACGAATGTGAGCCCATCGAGGCCATTGCCAAGTTTGACTACGTGGGCCGG ACAGCCCGAGAGCTGTCCTTTAAGAAGGGAGCATCCCTGCTGCTTTACCAGCGGGCTTCCGACGACTGGTGGGAAGGCCGGCACAATGGC ATCGACGGACTCATCCCCCATCAGTACATCGTGGTCCAAGACACCGAGGACGGTGTCGTGGAGAGGTCCAGCCCCAAGTCTGAGATTGAG GTCATTTCTGAGCCACCTGAAGAAAAGGTGACAGCCAGAGCGGGGGCCAGCTGTCCCAGTGGGGGTCATGTAGCCGATATTTATCTTGCA AACATCAACAAGCAAAGGAAGCGTCCAGAATCTGGGAGCATCCGGAAAACTTTTCGGAGTGACAGCCATGGGCTGAGCAGTTCCCTGACT GACTCCTCCTCCCCAGGGGTGGGGGCTAGCTGCCGCCCATCCTCCCAGCCCATCATGAGCCAGAGCCTCCCCAAAGAAGGGCCAGATAAG TGTTCCATCAGTGGGCACGGGAGCCTCAACTCCATCAGCCGCCACTCATCCCTGAAGAATCGGCTGGATAGTCCACAGATCCGGAAGACT GCCACAGCGGGAAGGTCAAAAAGCTTCAATAACCATCGGCCCATGGACCCTGAGGTCATTGCTCAGGATATTGAGGCAACAATGAACTCG GCCCTGAATGAGCTACGGGAACTAGAACGGCAGAGCAGTGTCAAACACACCCCTGACGTGGTTCTGGACACCTTGGAGCCCCTCAAAACC TCCCCAGTGGTGGCCCCCACGTCAGAGCCCTCCAGCCCTCTGCACACCCAGCTCCTCAAGGACCCCGAGCCCGCCTTCCAGCGCAGCGCC AGTACTGCTGGGGACATCGCCTGCGCCTTCCGGCCTGTCAAGTCTGTCAAGATGGCTGCCCCGGTCAAACCACCAGCCACACGGCCCAAG CCCACTGTCTTCCCCAAAACAAATGCCACTAGCCCTGGTGTCAACTCATCAACTTCCCCACAGTCTACTGACAAGTCTTGTACTGTCTGA GGGATAATAATTTAATTGTTCTAGACAAGGGGACTATAGGGACTGACTGTTATTAAAATCTTCCTATTTAACTAGCTTGGGGACTTCAGT TGAAAATTAGGTTCTAAGTTGTTCTTGCAGGAATTAGCCTCCCCGTCTCCCAAAACCTTGAGAATGAAGCCCTTGGTATCGCCTCTCCCT TCCCACTGCCCTCTGCTTCCCCCAGTCGTCGTAATTCAGCCAGCTGCAGTCCGTACCGTTCTTAGGTTAGCCAGAGACAGGTTTTCATTA TCAGGTCACTGTGAAATCTGGTAAGGCAGTCCTGAGGACATGGGCTCAAGTCTCAGTCCCCTCAGACCACGGTGATGCCTTGACCAGATG GTTGGCTACTGCCATCCAGCTTTCAGTGGCATCTTGTTTTGGGAACTGATTATAGAGAATCATATATAGTCCAGTCTTCATTTTACATAC ACACACATATTTTACACACACACACATTTTACACACACACACACACACACACACATATGTTTTTCTAGTCTCTGGCATGTGTAGCCTCTC CTGGTCATAGACCAGTCTCTTTGTAAGTTATTGTGGCAGTTCACACAGTAGCCACCAGGGGTCTCTGTTTCCATTACAAACTTTGTTCTG TCTGGGCCAGAGAACCTAGCCTTTGAAATCTCTCCATCATATGAAACATAACGGGATGGGACAATCCCGTAACCTGTTTGGGGTTGGGGG CTTTCTCTCTGTGTTCTTTCCATTGATGTGAATTGGTCATTGGTGTTTGCTCTTGCCTCTCCTCCATCCCCTAGAAGTACACCCCCGTCT TATTAAGGAGCTTTTAAAGTTTTTCTGAATGTATAGACATTTCTCGGGTTCCTACCTTTGTCTCTGATGGACCATTTTCCATTTAAGACA TTTTCCTGTATAAGACAGTTTTATAGCTGGTTCCTTTTAGGGTAAAGAGTCTTAAGAGAGTTTTATTGTGTCTATGGCAGGTTTGGGAAA GGTAAGAAATGGGTCCTTTTTCCTCCTAATGTTTTTGGCACTTAAAACATAAAATTCATTATCCTATTAAAAAATTAAATTCAGCTTTGC TAATCCAGAAATTGTTCCCAAATGAAAACTTGTTTTAAGTCCACCCCTTAGTTTCCTTATTTTACAAGGTCTCTCTTCAGGGACCAACAG GGGCTTAGAGAGCCTTAGTTAGATTAAAGGGAGACCCTACCTCTTAAAACCAGTTTTCATTTATGCAAACAAGGACAATTAAGGGAACCC TGACCCCACAGGCTCTCAAGTCTTCCCAAGGCCAGAATCGAAAGAAAATTAAAATTTGAATGCTGAATATTCTGGCTCTACTCTGGCCTT TTTTCTGGTTCCCTTCCAAAATGCACAAATCATACCCTTGTCTGCTCCAATTCAGTCTCCAAACCTGGTGCCTGTGCTCCTGGCCCCCCT AGCATCATGCTATCCCAGGAGTATCAGGACCAGACACATCCACAGCCAGGCTCATGGGTCTCAGACAGCAACTTGAGTTAAAGCTGAAAC TCATCCTTCTTCTCTGTGTTTTCTGGTTTAAAAGCTGCACTTATATTTTAGCCTTATTATTTTCTGTAGTTCCGGAGAGATGGTGGGTTG CCATTCTGGTAGGAAAATCTGAGTTTTCTTATCTTTGACCTAGAAGAGATTCTTTTTGGACCAACCTGCGAAATTGGTAGTTAGGTCTAT GGAAAGTGGTAGGATTTTTTTTTTTTAATCCTGTGCAAAGGAAAAGAGGTGCTTTGTGGGAAATCACTAATGAGAAGGCTAACCTGCAGC ACCAGAGAAACCTTTCCAAGTGCTAGGCAGGAGAACTGAAGAACTCTTTCAGTGAAGTGAGTCAGCCTAGAAGAGGCAACCCACAGTCTT GATTTTTGTTGCTGTTTCCTGACCTGTTCTTGCCTGTCACCTGGGCCTACACAGGTCCCGAGCCAACGGGGCTTTCATACCCAAGGATCT GTTTCCTTGCTGAAAATGAAACCCTATCTTTCACTTTACATTCCTTTCAATCCAACTGATCAAAACTGGTACCCACACTTGCCCTTTCTC CCTCTCTCCAGCACACTCCCCTCTAAGAAAGTAAAAGCAAAGCTTTCTTAATGGCAACACTTTGGGCCTGTTCTGTTGCTCCTGCCTTAT TTCTCTTTCAACCCTGTACATGACTCGTGTTCACCATCCCCTTGATCAGTGTCCATCCGCGCTAATTTGCATCATGAACTGAACAGTGTG TGAGTGGTCACCTACTAAACCCAGCTCTGGGGGCAGAGCTGTCTTCCCCATCTCTGGTGCTCCTAACACCTGTGAGATGGTCCTGTCGAG AGGACTAGGAACCGATAGGAGGAGAGTCCTTCTCGGCAGAGCTCACTGCAAACAACTGGAATTGAGGTTGCACACTGTGATTTTTACACC GAAAAGCCAAAAGGAGCTGGCCATCCAGGGCCTAGGGAGACCAGCCTTCCTCAGCTATGCTTGCCGAAACCAGCATGATGCTTCAAAGAG CCCTGCTCCACCCCTCATGGCATGGATCCTTTTCCTGGTGTGGACTCTGAAGGGTCAGTCTTCGGGGAAGAGAGGTGGGGTGGGGCTACT AGCATCCCAATTTAGAAAACAGAGGAGTTTGTAGCCAGCAGCCTGTAAACTGGAAACACTGGTCTCAGCCAACCTCCTCAGGGCGCCCTG GCTTCTCCCCAAGGAGATGAGGAGCGGTGATGCCAGCACCGGGATGCGCAGAGCACTGGAAGGGCTGGTGCAGATCTACTTCCCATGCAG AAGAGAAGTCACATCTTCCAGGGAATCGCAATGTTGTGGCGTCTGACTTGTATGTCACATTTGTGTAAAATGGTATATTCTTTAAAATAG TGTTGATAACTGGAATATTGTATGTATGCTTGGAGATGCTTTGTGTGAACCTAAGACTGTCACTCAACAGATGTTGGATTGGGGAAAATC >51398_51398_3_MAP4K3-SRGAP2_MAP4K3_chr2_39664033_ENST00000484274_SRGAP2_chr1_206557369_ENST00000414007_length(amino acids)=967AA_BP=36 MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKQSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGK SVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGY HASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQ SRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLI TKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQN DHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICF GPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAI AKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGG HVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRL DSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MAP4K3-SRGAP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAP4K3-SRGAP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAP4K3-SRGAP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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