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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4K4-TXNL4A (FusionGDB2 ID:51416)

Fusion Gene Summary for MAP4K4-TXNL4A

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K4-TXNL4A
Fusion gene ID: 51416
HgeneTgene
Gene symbol

MAP4K4

TXNL4A

Gene ID

9448

10907

Gene namemitogen-activated protein kinase kinase kinase kinase 4thioredoxin like 4A
SynonymsFLH21957|HEL-S-31|HGK|MEKKK4|NIKBMKS|DIB1|DIM1|SNRNP15|TXNL4|U5-15kD
Cytomap

2q11.2

18q23

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase-thioredoxin-like protein 4ADIM1 protein homologspliceosomal U5 snRNP-specific 15 kDa proteinthioredoxin-like 4thioredoxin-like U5 snRNP protein U5-15kD
Modification date2020031520200313
UniProtAcc

O95819

.
Ensembl transtripts involved in fusion geneENST00000302217, ENST00000324219, 
ENST00000347699, ENST00000350198, 
ENST00000413150, ENST00000425019, 
ENST00000456652, ENST00000350878, 
ENST00000498066, 		ENST00000585474, 
ENST00000591711, ENST00000592837, 
ENST00000592957, ENST00000588162, 
ENST00000589926, ENST00000269601, 
Fusion gene scores* DoF score16 X 11 X 9=15847 X 3 X 6=126
# samples 169
** MAII scorelog2(16/1584*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4K4 [Title/Abstract] AND TXNL4A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4K4(102407238)-TXNL4A(77737701), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K4

GO:0006468

protein phosphorylation

9890973

HgeneMAP4K4

GO:0035556

intracellular signal transduction

9890973

HgeneMAP4K4

GO:0046328

regulation of JNK cascade

14966141

TgeneTXNL4A

GO:0000398

mRNA splicing, via spliceosome

28781166


check buttonFusion gene breakpoints across MAP4K4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TXNL4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8366MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-


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Fusion Gene ORF analysis for MAP4K4-TXNL4A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000302217ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000302217ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000302217ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000302217ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000324219ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000324219ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000324219ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000324219ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000347699ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000347699ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000347699ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000347699ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000350198ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000350198ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000350198ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000350198ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000413150ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000413150ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000413150ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000413150ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000425019ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000425019ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000425019ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000425019ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000456652ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000456652ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000456652ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-5UTRENST00000456652ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000302217ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000302217ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000324219ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000324219ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000347699ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000347699ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000350198ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000350198ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000413150ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000413150ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000425019ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000425019ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000456652ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
5CDS-intronENST00000456652ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
In-frameENST00000302217ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
In-frameENST00000324219ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
In-frameENST00000347699ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
In-frameENST00000350198ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
In-frameENST00000413150ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
In-frameENST00000425019ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
In-frameENST00000456652ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-3CDSENST00000350878ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-3CDSENST00000498066ENST00000269601MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000350878ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000350878ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000350878ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000350878ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000498066ENST00000585474MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000498066ENST00000591711MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000498066ENST00000592837MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-5UTRENST00000498066ENST00000592957MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-intronENST00000350878ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-intronENST00000350878ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-intronENST00000498066ENST00000588162MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-
intron-intronENST00000498066ENST00000589926MAP4K4chr2

102407238

+TXNL4Achr18

77737701

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425019MAP4K4chr2102407238+ENST00000269601TXNL4Achr1877737701-1611517235792185
ENST00000324219MAP4K4chr2102407238+ENST00000269601TXNL4Achr1877737701-13482545529174
ENST00000350198MAP4K4chr2102407238+ENST00000269601TXNL4Achr1877737701-13482545529174
ENST00000302217MAP4K4chr2102407238+ENST00000269601TXNL4Achr1877737701-13482545529174
ENST00000413150MAP4K4chr2102407238+ENST00000269601TXNL4Achr1877737701-132923522510162
ENST00000347699MAP4K4chr2102407238+ENST00000269601TXNL4Achr1877737701-12741800455151
ENST00000456652MAP4K4chr2102407238+ENST00000269601TXNL4Achr1877737701-12741800455151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425019ENST00000269601MAP4K4chr2102407238+TXNL4Achr1877737701-0.001253830.99874616
ENST00000324219ENST00000269601MAP4K4chr2102407238+TXNL4Achr1877737701-0.0026689870.997331
ENST00000350198ENST00000269601MAP4K4chr2102407238+TXNL4Achr1877737701-0.0026689870.997331
ENST00000302217ENST00000269601MAP4K4chr2102407238+TXNL4Achr1877737701-0.0026689870.997331
ENST00000413150ENST00000269601MAP4K4chr2102407238+TXNL4Achr1877737701-0.001672470.99832755
ENST00000347699ENST00000269601MAP4K4chr2102407238+TXNL4Achr1877737701-0.0019973660.9980026
ENST00000456652ENST00000269601MAP4K4chr2102407238+TXNL4Achr1877737701-0.0019973660.9980026

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Fusion Genomic Features for MAP4K4-TXNL4A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP4K4-TXNL4A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:102407238/chr18:77737701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4K4

O95819

.
FUNCTION: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:9890973}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K4chr2:102407238chr18:77737701ENST00000347699+33031_39601240.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K4chr2:102407238chr18:77737701ENST00000347699+33025_289601240.0DomainProtein kinase
HgeneMAP4K4chr2:102407238chr18:77737701ENST00000347699+330926_1213601240.0DomainCNH


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Fusion Gene Sequence for MAP4K4-TXNL4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51416_51416_1_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000302217_TXNL4A_chr18_77737701_ENST00000269601_length(transcript)=1348nt_BP=254nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAGTTATGGATGTCACTGAGGTTAAAAATTTTGCAG
TTATTTATCTTGTGGATATTACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTCATGTTTTTCTTCAGGA
ACAAGCACATCATGATTGACTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAGATGGTGGACATCATCG
AGACGGTGTACCGCGGGGCCCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGCTACTGAGGCGCCCTCA
GTCTGCGCGGATAAATGTCGTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATACAGGAAGCTCCAGGGC
TGGAGCACCTCTGAGATGGAATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGCAGGCCTACTTGTTTGT
TCTCAGGAAACTTAATGAATAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAGGTGTTTATCCTGTGAG
CCTGTGCGTTTTGCATACTGGGTTGGTTTGCTGGGGCTGCGGTGACAGCATATGCCGCGAGCTGGGCTTTAACAGAGATGTGTGCTCTCA
CAGCTTTGCAGGCGGGGGTCTGAGATCAGGGTGTCGCGGGTGGGGGGTCACTGCTGAGGCCGTGAGGGGAATCTGCTCAGGCCTGTCCCT
GGCTTCTGGGGGCTGCTGGTGGTATTTTCAGTTCCTTGGTGTGTGGATACTTCGCCCCATCTCTGCCTTCACCTGTGTCCTCCCTGTGTG
GGTGCTGGTGTCCAAAATTTCCCCTTTTCGTAGTGACACCAGCTGTGTTGGATTGGGGCCCACCCTGCTCCAGCATGGCCTAATCTTAAC
TAATTACATTTGCAAGGATCTTATGTCCACAAAAGTCACAGTCTGAGGTGCTGGGGGTTAGGACTTCAATATATAAATTTTGCGGTTACA

>51416_51416_1_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000302217_TXNL4A_chr18_77737701_ENST00000269601_length(amino acids)=174AA_BP=83
MRLRYTERQRHLLLFVFWWQKGKMANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEVKNFAVI

--------------------------------------------------------------
>51416_51416_2_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000324219_TXNL4A_chr18_77737701_ENST00000269601_length(transcript)=1348nt_BP=254nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAGTTATGGATGTCACTGAGGTTAAAAATTTTGCAG
TTATTTATCTTGTGGATATTACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTCATGTTTTTCTTCAGGA
ACAAGCACATCATGATTGACTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAGATGGTGGACATCATCG
AGACGGTGTACCGCGGGGCCCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGCTACTGAGGCGCCCTCA
GTCTGCGCGGATAAATGTCGTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATACAGGAAGCTCCAGGGC
TGGAGCACCTCTGAGATGGAATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGCAGGCCTACTTGTTTGT
TCTCAGGAAACTTAATGAATAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAGGTGTTTATCCTGTGAG
CCTGTGCGTTTTGCATACTGGGTTGGTTTGCTGGGGCTGCGGTGACAGCATATGCCGCGAGCTGGGCTTTAACAGAGATGTGTGCTCTCA
CAGCTTTGCAGGCGGGGGTCTGAGATCAGGGTGTCGCGGGTGGGGGGTCACTGCTGAGGCCGTGAGGGGAATCTGCTCAGGCCTGTCCCT
GGCTTCTGGGGGCTGCTGGTGGTATTTTCAGTTCCTTGGTGTGTGGATACTTCGCCCCATCTCTGCCTTCACCTGTGTCCTCCCTGTGTG
GGTGCTGGTGTCCAAAATTTCCCCTTTTCGTAGTGACACCAGCTGTGTTGGATTGGGGCCCACCCTGCTCCAGCATGGCCTAATCTTAAC
TAATTACATTTGCAAGGATCTTATGTCCACAAAAGTCACAGTCTGAGGTGCTGGGGGTTAGGACTTCAATATATAAATTTTGCGGTTACA

>51416_51416_2_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000324219_TXNL4A_chr18_77737701_ENST00000269601_length(amino acids)=174AA_BP=83
MRLRYTERQRHLLLFVFWWQKGKMANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEVKNFAVI

--------------------------------------------------------------
>51416_51416_3_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000347699_TXNL4A_chr18_77737701_ENST00000269601_length(transcript)=1274nt_BP=180nt
ATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTG
GTTGGAAATGGCACCTATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAGTTATGGATGTCACTGAG
GTTAAAAATTTTGCAGTTATTTATCTTGTGGATATTACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTC
ATGTTTTTCTTCAGGAACAAGCACATCATGATTGACTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAG
ATGGTGGACATCATCGAGACGGTGTACCGCGGGGCCCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGC
TACTGAGGCGCCCTCAGTCTGCGCGGATAAATGTCGTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATA
CAGGAAGCTCCAGGGCTGGAGCACCTCTGAGATGGAATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGC
AGGCCTACTTGTTTGTTCTCAGGAAACTTAATGAATAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAG
GTGTTTATCCTGTGAGCCTGTGCGTTTTGCATACTGGGTTGGTTTGCTGGGGCTGCGGTGACAGCATATGCCGCGAGCTGGGCTTTAACA
GAGATGTGTGCTCTCACAGCTTTGCAGGCGGGGGTCTGAGATCAGGGTGTCGCGGGTGGGGGGTCACTGCTGAGGCCGTGAGGGGAATCT
GCTCAGGCCTGTCCCTGGCTTCTGGGGGCTGCTGGTGGTATTTTCAGTTCCTTGGTGTGTGGATACTTCGCCCCATCTCTGCCTTCACCT
GTGTCCTCCCTGTGTGGGTGCTGGTGTCCAAAATTTCCCCTTTTCGTAGTGACACCAGCTGTGTTGGATTGGGGCCCACCCTGCTCCAGC
ATGGCCTAATCTTAACTAATTACATTTGCAAGGATCTTATGTCCACAAAAGTCACAGTCTGAGGTGCTGGGGGTTAGGACTTCAATATAT
AAATTTTGCGGTTACACAATTCAATCCATGACAGAATCCAAAGGTTTACTCTGGTTATAAAAACAGTACAATAAAATATTGTTTATAGCC

>51416_51416_3_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000347699_TXNL4A_chr18_77737701_ENST00000269601_length(amino acids)=151AA_BP=60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEVKNFAVIYLVDITEVPDFNKMYELYDPCTV

--------------------------------------------------------------
>51416_51416_4_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000350198_TXNL4A_chr18_77737701_ENST00000269601_length(transcript)=1348nt_BP=254nt
CTGGTCTGCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCC
CTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCT
ATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAGTTATGGATGTCACTGAGGTTAAAAATTTTGCAG
TTATTTATCTTGTGGATATTACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTCATGTTTTTCTTCAGGA
ACAAGCACATCATGATTGACTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAGATGGTGGACATCATCG
AGACGGTGTACCGCGGGGCCCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGCTACTGAGGCGCCCTCA
GTCTGCGCGGATAAATGTCGTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATACAGGAAGCTCCAGGGC
TGGAGCACCTCTGAGATGGAATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGCAGGCCTACTTGTTTGT
TCTCAGGAAACTTAATGAATAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAGGTGTTTATCCTGTGAG
CCTGTGCGTTTTGCATACTGGGTTGGTTTGCTGGGGCTGCGGTGACAGCATATGCCGCGAGCTGGGCTTTAACAGAGATGTGTGCTCTCA
CAGCTTTGCAGGCGGGGGTCTGAGATCAGGGTGTCGCGGGTGGGGGGTCACTGCTGAGGCCGTGAGGGGAATCTGCTCAGGCCTGTCCCT
GGCTTCTGGGGGCTGCTGGTGGTATTTTCAGTTCCTTGGTGTGTGGATACTTCGCCCCATCTCTGCCTTCACCTGTGTCCTCCCTGTGTG
GGTGCTGGTGTCCAAAATTTCCCCTTTTCGTAGTGACACCAGCTGTGTTGGATTGGGGCCCACCCTGCTCCAGCATGGCCTAATCTTAAC
TAATTACATTTGCAAGGATCTTATGTCCACAAAAGTCACAGTCTGAGGTGCTGGGGGTTAGGACTTCAATATATAAATTTTGCGGTTACA

>51416_51416_4_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000350198_TXNL4A_chr18_77737701_ENST00000269601_length(amino acids)=174AA_BP=83
MRLRYTERQRHLLLFVFWWQKGKMANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEVKNFAVI

--------------------------------------------------------------
>51416_51416_5_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000413150_TXNL4A_chr18_77737701_ENST00000269601_length(transcript)=1329nt_BP=235nt
CACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGA
CATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACAAGTCTATAAGGG
TCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAGTTATGGATGTCACTGAGGTTAAAAATTTTGCAGTTATTTATCTTGTGGATAT
TACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTCATGTTTTTCTTCAGGAACAAGCACATCATGATTGA
CTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAGATGGTGGACATCATCGAGACGGTGTACCGCGGGGC
CCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGCTACTGAGGCGCCCTCAGTCTGCGCGGATAAATGTC
GTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATACAGGAAGCTCCAGGGCTGGAGCACCTCTGAGATGG
AATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGCAGGCCTACTTGTTTGTTCTCAGGAAACTTAATGAA
TAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAGGTGTTTATCCTGTGAGCCTGTGCGTTTTGCATACT
GGGTTGGTTTGCTGGGGCTGCGGTGACAGCATATGCCGCGAGCTGGGCTTTAACAGAGATGTGTGCTCTCACAGCTTTGCAGGCGGGGGT
CTGAGATCAGGGTGTCGCGGGTGGGGGGTCACTGCTGAGGCCGTGAGGGGAATCTGCTCAGGCCTGTCCCTGGCTTCTGGGGGCTGCTGG
TGGTATTTTCAGTTCCTTGGTGTGTGGATACTTCGCCCCATCTCTGCCTTCACCTGTGTCCTCCCTGTGTGGGTGCTGGTGTCCAAAATT
TCCCCTTTTCGTAGTGACACCAGCTGTGTTGGATTGGGGCCCACCCTGCTCCAGCATGGCCTAATCTTAACTAATTACATTTGCAAGGAT
CTTATGTCCACAAAAGTCACAGTCTGAGGTGCTGGGGGTTAGGACTTCAATATATAAATTTTGCGGTTACACAATTCAATCCATGACAGA

>51416_51416_5_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000413150_TXNL4A_chr18_77737701_ENST00000269601_length(amino acids)=162AA_BP=71
MLFVFWWQKGKMANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEVKNFAVIYLVDITEVPDFN

--------------------------------------------------------------
>51416_51416_6_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000425019_TXNL4A_chr18_77737701_ENST00000269601_length(transcript)=1611nt_BP=517nt
GGGCCCGTCCTCGAGGCGCGCGGCGCGGGGCGCGGGCGCCGGGGCCTGAGGCGGCGGGCGACGCCCGGGGGCCTGACGGCCGGCCCCGCG
CCATGGTGTGAGCGCCGCCGCCCGTGCACGCTCCGTCCGCCCTCCGCGCGGCCCGGCCGGCAGAGAGCCCCGAGCGGCCCGAGAGCGCAG
CCGAGCCCGCCGCCGCCGCCCGCGGCCCCGCGAGGAGAGTACCGGGCCGGCTCGGCTGCCGCGCGAGGAGCGCGGTCGGCGGCCTGGTCT
GCGGCTGAGATACACAGAGCGACAGAGACATTTATTGTTATTTGTTTTTTGGTGGCAAAAAGGGAAAATGGCGAACGACTCCCCTGCAAA
AAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTGGTTGGAAATGGCACCTATGGACA
AGTCTATAAGGGTCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAGTTATGGATGTCACTGAGGTTAAAAATTTTGCAGTTATTTA
TCTTGTGGATATTACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTCATGTTTTTCTTCAGGAACAAGCA
CATCATGATTGACTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAGATGGTGGACATCATCGAGACGGT
GTACCGCGGGGCCCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGCTACTGAGGCGCCCTCAGTCTGCG
CGGATAAATGTCGTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATACAGGAAGCTCCAGGGCTGGAGCA
CCTCTGAGATGGAATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGCAGGCCTACTTGTTTGTTCTCAGG
AAACTTAATGAATAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAGGTGTTTATCCTGTGAGCCTGTGC
GTTTTGCATACTGGGTTGGTTTGCTGGGGCTGCGGTGACAGCATATGCCGCGAGCTGGGCTTTAACAGAGATGTGTGCTCTCACAGCTTT
GCAGGCGGGGGTCTGAGATCAGGGTGTCGCGGGTGGGGGGTCACTGCTGAGGCCGTGAGGGGAATCTGCTCAGGCCTGTCCCTGGCTTCT
GGGGGCTGCTGGTGGTATTTTCAGTTCCTTGGTGTGTGGATACTTCGCCCCATCTCTGCCTTCACCTGTGTCCTCCCTGTGTGGGTGCTG
GTGTCCAAAATTTCCCCTTTTCGTAGTGACACCAGCTGTGTTGGATTGGGGCCCACCCTGCTCCAGCATGGCCTAATCTTAACTAATTAC
ATTTGCAAGGATCTTATGTCCACAAAAGTCACAGTCTGAGGTGCTGGGGGTTAGGACTTCAATATATAAATTTTGCGGTTACACAATTCA

>51416_51416_6_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000425019_TXNL4A_chr18_77737701_ENST00000269601_length(amino acids)=185AA_BP=94
MPREERGRRPGLRLRYTERQRHLLLFVFWWQKGKMANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM
DVTEVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYS

--------------------------------------------------------------
>51416_51416_7_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000456652_TXNL4A_chr18_77737701_ENST00000269601_length(transcript)=1274nt_BP=180nt
ATGGCGAACGACTCCCCTGCAAAAAGTCTGGTGGACATCGACCTCTCCTCCCTGCGGGATCCTGCTGGGATTTTTGAGCTGGTGGAAGTG
GTTGGAAATGGCACCTATGGACAAGTCTATAAGGGTCGACATGTTAAAACGGGTCAGTTGGCAGCCATCAAAGTTATGGATGTCACTGAG
GTTAAAAATTTTGCAGTTATTTATCTTGTGGATATTACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTC
ATGTTTTTCTTCAGGAACAAGCACATCATGATTGACTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAG
ATGGTGGACATCATCGAGACGGTGTACCGCGGGGCCCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGC
TACTGAGGCGCCCTCAGTCTGCGCGGATAAATGTCGTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATA
CAGGAAGCTCCAGGGCTGGAGCACCTCTGAGATGGAATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGC
AGGCCTACTTGTTTGTTCTCAGGAAACTTAATGAATAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAG
GTGTTTATCCTGTGAGCCTGTGCGTTTTGCATACTGGGTTGGTTTGCTGGGGCTGCGGTGACAGCATATGCCGCGAGCTGGGCTTTAACA
GAGATGTGTGCTCTCACAGCTTTGCAGGCGGGGGTCTGAGATCAGGGTGTCGCGGGTGGGGGGTCACTGCTGAGGCCGTGAGGGGAATCT
GCTCAGGCCTGTCCCTGGCTTCTGGGGGCTGCTGGTGGTATTTTCAGTTCCTTGGTGTGTGGATACTTCGCCCCATCTCTGCCTTCACCT
GTGTCCTCCCTGTGTGGGTGCTGGTGTCCAAAATTTCCCCTTTTCGTAGTGACACCAGCTGTGTTGGATTGGGGCCCACCCTGCTCCAGC
ATGGCCTAATCTTAACTAATTACATTTGCAAGGATCTTATGTCCACAAAAGTCACAGTCTGAGGTGCTGGGGGTTAGGACTTCAATATAT
AAATTTTGCGGTTACACAATTCAATCCATGACAGAATCCAAAGGTTTACTCTGGTTATAAAAACAGTACAATAAAATATTGTTTATAGCC

>51416_51416_7_MAP4K4-TXNL4A_MAP4K4_chr2_102407238_ENST00000456652_TXNL4A_chr18_77737701_ENST00000269601_length(amino acids)=151AA_BP=60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEVKNFAVIYLVDITEVPDFNKMYELYDPCTV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for MAP4K4-TXNL4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4K4-TXNL4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP4K4-TXNL4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource