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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAP4K5-L2HGDH (FusionGDB2 ID:51422)

Fusion Gene Summary for MAP4K5-L2HGDH

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K5-L2HGDH
Fusion gene ID: 51422
HgeneTgene
Gene symbol

MAP4K5

L2HGDH

Gene ID

11183

79944

Gene namemitogen-activated protein kinase kinase kinase kinase 5L-2-hydroxyglutarate dehydrogenase
SynonymsGCKR|KHS|KHS1|MAPKKKK5C14orf160|L2HGA
Cytomap

14q22.1

14q21.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 5MAPK/ERK kinase kinase kinase 5MEK kinase kinase 5MEKKK 5germinal center kinase-relatedkinase homologous to SPS1/STE20L-2-hydroxyglutarate dehydrogenase, mitochondrial2-hydroxyglutarate dehydrogenaseL-alpha-hydroxyglutarate dehydrogenasealpha-hydroxyglutarate oxidoreductasealpha-ketoglutarate reductaseduranin
Modification date2020031320200313
UniProtAcc.

Q9H9P8

Ensembl transtripts involved in fusion geneENST00000013125, ENST00000557578, 
ENST00000555423, ENST00000555610, 
ENST00000556393, ENST00000261699, 
ENST00000267436, ENST00000421284, 
Fusion gene scores* DoF score21 X 18 X 10=378011 X 9 X 6=594
# samples 2713
** MAII scorelog2(27/3780*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/594*10)=-2.19195130777231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4K5 [Title/Abstract] AND L2HGDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAP4K5(50901112)-L2HGDH(50736048), # samples:2
MAP4K5(50901111)-L2HGDH(50736048), # samples:2
L2HGDH(50778729)-MAP4K5(50915550), # samples:1
Anticipated loss of major functional domain due to fusion event.L2HGDH-MAP4K5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
L2HGDH-MAP4K5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
L2HGDH-MAP4K5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
L2HGDH-MAP4K5 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K5

GO:0006468

protein phosphorylation

9038372

HgeneMAP4K5

GO:0035556

intracellular signal transduction

9038372

TgeneL2HGDH

GO:0044267

cellular protein metabolic process

16005139


check buttonFusion gene breakpoints across MAP4K5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across L2HGDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GQ-01AMAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
ChimerDB4ESCATCGA-2H-A9GQMAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
ChimerDB4ESCATCGA-2H-A9GQMAP4K5chr14

50901112

-L2HGDHchr14

50736048

-


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Fusion Gene ORF analysis for MAP4K5-L2HGDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000013125ENST00000555423MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
5CDS-intronENST00000013125ENST00000555423MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
5CDS-intronENST00000013125ENST00000555610MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
5CDS-intronENST00000013125ENST00000555610MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
5CDS-intronENST00000013125ENST00000556393MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
5CDS-intronENST00000013125ENST00000556393MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
In-frameENST00000013125ENST00000261699MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
In-frameENST00000013125ENST00000261699MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
In-frameENST00000013125ENST00000267436MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
In-frameENST00000013125ENST00000267436MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
In-frameENST00000013125ENST00000421284MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
In-frameENST00000013125ENST00000421284MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
intron-3CDSENST00000557578ENST00000261699MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
intron-3CDSENST00000557578ENST00000261699MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
intron-3CDSENST00000557578ENST00000267436MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
intron-3CDSENST00000557578ENST00000267436MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
intron-3CDSENST00000557578ENST00000421284MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
intron-3CDSENST00000557578ENST00000421284MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
intron-intronENST00000557578ENST00000555423MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
intron-intronENST00000557578ENST00000555423MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
intron-intronENST00000557578ENST00000555610MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
intron-intronENST00000557578ENST00000555610MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-
intron-intronENST00000557578ENST00000556393MAP4K5chr14

50901112

-L2HGDHchr14

50736048

-
intron-intronENST00000557578ENST00000556393MAP4K5chr14

50901111

-L2HGDHchr14

50736048

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000013125MAP4K5chr1450901112-ENST00000261699L2HGDHchr1450736048-310424833192568749
ENST00000013125MAP4K5chr1450901112-ENST00000267436L2HGDHchr1450736048-479324833192568749
ENST00000013125MAP4K5chr1450901112-ENST00000421284L2HGDHchr1450736048-362424833192568749
ENST00000013125MAP4K5chr1450901111-ENST00000261699L2HGDHchr1450736048-310424833192568749
ENST00000013125MAP4K5chr1450901111-ENST00000267436L2HGDHchr1450736048-479324833192568749
ENST00000013125MAP4K5chr1450901111-ENST00000421284L2HGDHchr1450736048-362424833192568749

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000013125ENST00000261699MAP4K5chr1450901112-L2HGDHchr1450736048-0.0008734180.9991266
ENST00000013125ENST00000267436MAP4K5chr1450901112-L2HGDHchr1450736048-0.0006471320.9993529
ENST00000013125ENST00000421284MAP4K5chr1450901112-L2HGDHchr1450736048-0.0009387780.9990613
ENST00000013125ENST00000261699MAP4K5chr1450901111-L2HGDHchr1450736048-0.0008734180.9991266
ENST00000013125ENST00000267436MAP4K5chr1450901111-L2HGDHchr1450736048-0.0006471320.9993529
ENST00000013125ENST00000421284MAP4K5chr1450901111-L2HGDHchr1450736048-0.0009387780.9990613

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Fusion Genomic Features for MAP4K5-L2HGDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAP4K5-L2HGDH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:50901112/chr14:50736048)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.L2HGDH

Q9H9P8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K5chr14:50901111chr14:50736048ENST00000013125-273220_277721847.0DomainProtein kinase
HgeneMAP4K5chr14:50901112chr14:50736048ENST00000013125-273220_277721847.0DomainProtein kinase
HgeneMAP4K5chr14:50901111chr14:50736048ENST00000013125-273226_34721847.0Nucleotide bindingATP
HgeneMAP4K5chr14:50901112chr14:50736048ENST00000013125-273226_34721847.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP4K5chr14:50901111chr14:50736048ENST00000013125-2732506_819721847.0DomainCNH
HgeneMAP4K5chr14:50901112chr14:50736048ENST00000013125-2732506_819721847.0DomainCNH


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Fusion Gene Sequence for MAP4K5-L2HGDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>51422_51422_1_MAP4K5-L2HGDH_MAP4K5_chr14_50901111_ENST00000013125_L2HGDH_chr14_50736048_ENST00000261699_length(transcript)=3104nt_BP=2483nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA
TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA
TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA
AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA
AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG
CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT
GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT
CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG
AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA
TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT
TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT
TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA
CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG
CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC
ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT
GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA
CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG
TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT
TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC
AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC
TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT
TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT
TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG
CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA
AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA
TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA
TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG
GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGCAGGTGGCTGTGAGAGGACCGAGCTGGC
TATGGCAGCAACCCATGAAAGTGAGTGATAACAACATTTATTGTTTCCTGTGGCGTTGCTTTGCTTTGCTATTGACTGGTAGCGCTTGTA

>51422_51422_1_MAP4K5-L2HGDH_MAP4K5_chr14_50901111_ENST00000013125_L2HGDH_chr14_50736048_ENST00000261699_length(amino acids)=749AA_BP=0
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL
WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER
LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD
GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN
PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG

--------------------------------------------------------------
>51422_51422_2_MAP4K5-L2HGDH_MAP4K5_chr14_50901111_ENST00000013125_L2HGDH_chr14_50736048_ENST00000267436_length(transcript)=4793nt_BP=2483nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA
TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA
TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA
AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA
AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG
CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT
GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT
CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG
AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA
TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT
TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT
TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA
CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG
CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC
ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT
GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA
CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG
TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT
TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC
AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC
TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT
TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT
TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG
CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA
AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA
TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA
TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG
GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCC
TGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCAC
CTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAG
CTAGGTATGCACTGTAATCTTCATGTCAGCAACAAGAATGTACTAATTGCATTCTTTAATTTAAAAAATGGTTTTTAAACTTTAGTTTTT
AGGTCAAAGATAACCACTGCATTGTTAAAATGATGTAACATAGAAATAATAATTTTCTACAAAAATTAGCCAGGCATGGTGGCGCATGCC
TGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCAATTGAACCGAGCAGACGGAGGTGAGCTGAGAGCTGAGATTGCACCACTGC
ACTCCAGCCTGGGTGACAGAGCAAGAAAATAATAATAATAATAATTTTCAAAATGTTAGGCTGGGGGCCGTGGCCAGCACTTTGGGAAGC
CAAGGCAGGTAGATTGTAGCCCAGGAGTTTGAGAACAGCCTGGGCAACATGGCAAAACCCTGTTTCTACACAAAGTTAGCTGGGTCTGGT
GCCTCTGTAGTTCCAGCTCCTCAGTAGGCTGAGGTGAGAGGATCACTTGAGCCCAGGAGGTCTAGGCTGCAGTGAGCTTATGTTCATGAC
ACTGCATTCCAGGCTGGATGATAGAGCAAGATCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGCCTGGGCAACATAGTGAAT
GAAACCCCATCTCTACAAAAAATACAAAAATTAGCTGGGCATGATGGTGTGTGCCTGTAGTCCCAGCTACTTGGGGGCTGAGGCAGGAGG
ATCGCTTGAGCCCGGGAGATCAAGGCTACAGTGAGCTGTGTTCATGCCACTATACCCCAGCCTGGGCAACAAAGTGAGTCCCTGACTCAA
AAAATAAAAACAACAACAAAAAATAAATTCCATGCTTATTTACTTTGCGAATAAAGAGGCAAGGTACAGTTTTATCTGTCCGAATCCCTG
ACTTTTATTTATTTTTTTTTTCAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCT
GCCTCCCGGGTTCCAGCGATTCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTA
TTTTTAGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAAT
GCTGGGATTACAGGTGCGAGCCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGA
TTTGGCTTTTTAAGAGTTTTGGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGT
TTGGTCTCTCATAGACAAGAAAATACATTATATTGTAGGTTACATTCTTTTAATTTTGAAGAGTCACAAAACTCACATTATTTAGAGCAA
CAATATTTGTATTTGGAAATTAAAAATTCATGATTTCAAGAAAATACATAAAATTTACATTTTTGAGTAGTTTGAATAAGTTTCTATCTT
AATTATAATATTTGTAGGAAATAACAAAACAAACTCAAAGCCTTTATTATTTCCAGTCTCTTTGTAACTGATGTGGTATGGTATCATCAT

>51422_51422_2_MAP4K5-L2HGDH_MAP4K5_chr14_50901111_ENST00000013125_L2HGDH_chr14_50736048_ENST00000267436_length(amino acids)=749AA_BP=0
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL
WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER
LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD
GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN
PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG

--------------------------------------------------------------
>51422_51422_3_MAP4K5-L2HGDH_MAP4K5_chr14_50901111_ENST00000013125_L2HGDH_chr14_50736048_ENST00000421284_length(transcript)=3624nt_BP=2483nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA
TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA
TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA
AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA
AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG
CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT
GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT
CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG
AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA
TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT
TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT
TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA
CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG
CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC
ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT
GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA
CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG
TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT
TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC
AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC
TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT
TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT
TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG
CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA
AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA
TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA
TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG
GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCC
TGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCAC
CTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAG
CTAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCCAGCGAT
TCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTT
TTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAATGCTGGGATTACAGGTGCGAG
CCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGATTTGGCTTTTTAAGAGTTTT
GGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGTTTGGTCTCTCATAGACAAGA

>51422_51422_3_MAP4K5-L2HGDH_MAP4K5_chr14_50901111_ENST00000013125_L2HGDH_chr14_50736048_ENST00000421284_length(amino acids)=749AA_BP=0
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL
WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER
LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD
GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN
PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG

--------------------------------------------------------------
>51422_51422_4_MAP4K5-L2HGDH_MAP4K5_chr14_50901112_ENST00000013125_L2HGDH_chr14_50736048_ENST00000261699_length(transcript)=3104nt_BP=2483nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA
TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA
TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA
AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA
AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG
CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT
GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT
CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG
AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA
TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT
TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT
TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA
CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG
CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC
ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT
GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA
CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG
TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT
TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC
AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC
TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT
TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT
TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG
CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA
AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA
TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA
TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG
GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGCAGGTGGCTGTGAGAGGACCGAGCTGGC
TATGGCAGCAACCCATGAAAGTGAGTGATAACAACATTTATTGTTTCCTGTGGCGTTGCTTTGCTTTGCTATTGACTGGTAGCGCTTGTA

>51422_51422_4_MAP4K5-L2HGDH_MAP4K5_chr14_50901112_ENST00000013125_L2HGDH_chr14_50736048_ENST00000261699_length(amino acids)=749AA_BP=0
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL
WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER
LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD
GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN
PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG

--------------------------------------------------------------
>51422_51422_5_MAP4K5-L2HGDH_MAP4K5_chr14_50901112_ENST00000013125_L2HGDH_chr14_50736048_ENST00000267436_length(transcript)=4793nt_BP=2483nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA
TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA
TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA
AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA
AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG
CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT
GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT
CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG
AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA
TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT
TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT
TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA
CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG
CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC
ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT
GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA
CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG
TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT
TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC
AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC
TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT
TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT
TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG
CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA
AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA
TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA
TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG
GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCC
TGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCAC
CTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAG
CTAGGTATGCACTGTAATCTTCATGTCAGCAACAAGAATGTACTAATTGCATTCTTTAATTTAAAAAATGGTTTTTAAACTTTAGTTTTT
AGGTCAAAGATAACCACTGCATTGTTAAAATGATGTAACATAGAAATAATAATTTTCTACAAAAATTAGCCAGGCATGGTGGCGCATGCC
TGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCAATTGAACCGAGCAGACGGAGGTGAGCTGAGAGCTGAGATTGCACCACTGC
ACTCCAGCCTGGGTGACAGAGCAAGAAAATAATAATAATAATAATTTTCAAAATGTTAGGCTGGGGGCCGTGGCCAGCACTTTGGGAAGC
CAAGGCAGGTAGATTGTAGCCCAGGAGTTTGAGAACAGCCTGGGCAACATGGCAAAACCCTGTTTCTACACAAAGTTAGCTGGGTCTGGT
GCCTCTGTAGTTCCAGCTCCTCAGTAGGCTGAGGTGAGAGGATCACTTGAGCCCAGGAGGTCTAGGCTGCAGTGAGCTTATGTTCATGAC
ACTGCATTCCAGGCTGGATGATAGAGCAAGATCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGCCTGGGCAACATAGTGAAT
GAAACCCCATCTCTACAAAAAATACAAAAATTAGCTGGGCATGATGGTGTGTGCCTGTAGTCCCAGCTACTTGGGGGCTGAGGCAGGAGG
ATCGCTTGAGCCCGGGAGATCAAGGCTACAGTGAGCTGTGTTCATGCCACTATACCCCAGCCTGGGCAACAAAGTGAGTCCCTGACTCAA
AAAATAAAAACAACAACAAAAAATAAATTCCATGCTTATTTACTTTGCGAATAAAGAGGCAAGGTACAGTTTTATCTGTCCGAATCCCTG
ACTTTTATTTATTTTTTTTTTCAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCT
GCCTCCCGGGTTCCAGCGATTCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTA
TTTTTAGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAAT
GCTGGGATTACAGGTGCGAGCCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGA
TTTGGCTTTTTAAGAGTTTTGGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGT
TTGGTCTCTCATAGACAAGAAAATACATTATATTGTAGGTTACATTCTTTTAATTTTGAAGAGTCACAAAACTCACATTATTTAGAGCAA
CAATATTTGTATTTGGAAATTAAAAATTCATGATTTCAAGAAAATACATAAAATTTACATTTTTGAGTAGTTTGAATAAGTTTCTATCTT
AATTATAATATTTGTAGGAAATAACAAAACAAACTCAAAGCCTTTATTATTTCCAGTCTCTTTGTAACTGATGTGGTATGGTATCATCAT

>51422_51422_5_MAP4K5-L2HGDH_MAP4K5_chr14_50901112_ENST00000013125_L2HGDH_chr14_50736048_ENST00000267436_length(amino acids)=749AA_BP=0
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL
WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER
LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD
GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN
PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG

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>51422_51422_6_MAP4K5-L2HGDH_MAP4K5_chr14_50901112_ENST00000013125_L2HGDH_chr14_50736048_ENST00000421284_length(transcript)=3624nt_BP=2483nt
GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG
GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC
GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG
AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG
GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA
GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA
TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA
TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA
AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA
AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG
CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT
GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT
CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG
AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA
TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT
TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT
TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA
CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG
CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC
ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT
GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA
CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG
TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT
TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC
AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC
TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT
TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT
TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG
CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA
AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA
TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA
TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG
GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCC
TGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCAC
CTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAG
CTAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCCAGCGAT
TCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTT
TTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAATGCTGGGATTACAGGTGCGAG
CCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGATTTGGCTTTTTAAGAGTTTT
GGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGTTTGGTCTCTCATAGACAAGA

>51422_51422_6_MAP4K5-L2HGDH_MAP4K5_chr14_50901112_ENST00000013125_L2HGDH_chr14_50736048_ENST00000421284_length(amino acids)=749AA_BP=0
MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL
WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY
WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER
LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL
SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD
GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE
LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN
PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG

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Fusion Gene PPI Analysis for MAP4K5-L2HGDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAP4K5-L2HGDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAP4K5-L2HGDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource