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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAPK10-ARHGAP24 (FusionGDB2 ID:51494)

Fusion Gene Summary for MAPK10-ARHGAP24

Fusion gene summary

Fusion gene information	Fusion gene name: MAPK10-ARHGAP24
	Fusion gene ID: 51494
		Hgene	Tgene
	Gene symbol	MAPK10	ARHGAP24
	Gene ID	5602	83478
	Gene name	mitogen-activated protein kinase 10	Rho GTPase activating protein 24
	Synonyms	JNK3\|JNK3A\|PRKM10\|SAPK1b\|p493F12\|p54bSAPK	FILGAP\|RC-GAP72\|RCGAP72\|p73\|p73RhoGAP
	Cytomap	4q21.3	4q21.23-q21.3
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3	rho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88
	Modification date	20200313	20200313
	UniProtAcc	P53779	Q8N264
	Ensembl transtripts involved in fusion gene	ENST00000359221, ENST00000361569, ENST00000395161, ENST00000395166, ENST00000395169, ENST00000449047, ENST00000513839, ENST00000395157, ENST00000395160,	ENST00000395184, ENST00000503995, ENST00000264343, ENST00000395183, ENST00000506421,
Fusion gene scores	* DoF score	12 X 11 X 7=924	9 X 10 X 3=270
	# samples	14	10
	** MAII score	log2(14/924*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAPK10 [Title/Abstract] AND ARHGAP24 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARHGAP24(86700118)-MAPK10(87115560), # samples:2 ARHGAP24(86863426)-MAPK10(86938523), # samples:2 ARHGAP24(86863426)-MAPK10(86938528), # samples:2 MAPK10(87275683)-ARHGAP24(86893189), # samples:2
Anticipated loss of major functional domain due to fusion event.	ARHGAP24-MAPK10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ARHGAP24-MAPK10 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. ARHGAP24-MAPK10 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAPK10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DH-A669-01A	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
ChimerDB4	LGG	TCGA-DH-A669-02A	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
ChimerDB4	LGG	TCGA-DH-A669	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+

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Fusion Gene ORF analysis for MAPK10-ARHGAP24

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000359221	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000359221	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000359221	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000359221	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000361569	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000361569	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000361569	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000361569	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000395161	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000395161	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000395161	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000395161	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000395166	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000395166	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000395166	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000395166	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000395169	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000395169	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000395169	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000395169	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000449047	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000449047	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000449047	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000449047	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000513839	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000513839	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-3CDS	ENST00000513839	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-3CDS	ENST00000513839	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000359221	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000359221	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000359221	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000359221	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000359221	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000359221	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000361569	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000361569	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000361569	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000361569	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000361569	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000361569	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395161	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395161	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395161	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395161	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395161	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395161	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395166	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395166	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395166	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395166	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395166	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395166	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395169	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395169	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395169	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395169	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000395169	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000395169	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000449047	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000449047	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000449047	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000449047	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000449047	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000449047	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000513839	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000513839	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000513839	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000513839	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
5UTR-intron	ENST00000513839	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
5UTR-intron	ENST00000513839	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-3CDS	ENST00000395157	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-3CDS	ENST00000395157	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-3CDS	ENST00000395157	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-3CDS	ENST00000395157	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-3CDS	ENST00000395160	ENST00000395184	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-3CDS	ENST00000395160	ENST00000395184	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-3CDS	ENST00000395160	ENST00000503995	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-3CDS	ENST00000395160	ENST00000503995	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-intron	ENST00000395157	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-intron	ENST00000395157	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-intron	ENST00000395157	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-intron	ENST00000395157	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-intron	ENST00000395157	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-intron	ENST00000395157	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-intron	ENST00000395160	ENST00000264343	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-intron	ENST00000395160	ENST00000264343	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-intron	ENST00000395160	ENST00000395183	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-intron	ENST00000395160	ENST00000395183	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+
intron-intron	ENST00000395160	ENST00000506421	MAPK10	chr4	87275683	-	ARHGAP24	chr4	86893189	+
intron-intron	ENST00000395160	ENST00000506421	MAPK10	chr4	87275682	-	ARHGAP24	chr4	86893188	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for MAPK10-ARHGAP24

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAPK10-ARHGAP24

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:86700118/:87115560)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAPK10 P53779	ARHGAP24 Q8N264
FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269\|PubMed:11718727, ECO:0000269\|PubMed:22327296, ECO:0000269\|PubMed:22441692}.	FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269\|PubMed:15302923, ECO:0000269\|PubMed:15611138, ECO:0000269\|PubMed:16862148}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for MAPK10-ARHGAP24

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAPK10-ARHGAP24

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for MAPK10-ARHGAP24

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MAPK10-ARHGAP24

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source