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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAPK10-PTPN13 (FusionGDB2 ID:51503)

Fusion Gene Summary for MAPK10-PTPN13

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK10-PTPN13
Fusion gene ID: 51503
HgeneTgene
Gene symbol

MAPK10

PTPN13

Gene ID

5602

5783

Gene namemitogen-activated protein kinase 10protein tyrosine phosphatase non-receptor type 13
SynonymsJNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPKFAP-1|PNP1|PTP-BAS|PTP-BL|PTP1E|PTPL1|PTPLE|hPTP1E
Cytomap

4q21.3

4q21.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3tyrosine-protein phosphatase non-receptor type 13fas-associated protein-tyrosine phosphatase 1hPTPE1protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)protein-tyrosine phosphatase 1Eprotein-tyrosine phosphatas
Modification date2020031320200313
UniProtAcc

P53779

PRY,PRY2

Ensembl transtripts involved in fusion geneENST00000359221, ENST00000361569, 
ENST00000395161, ENST00000395166, 
ENST00000395169, ENST00000449047, 
ENST00000513839, ENST00000395157, 
ENST00000395160, 		ENST00000427191, 
ENST00000436978, ENST00000316707, 
ENST00000411767, ENST00000502971, 
ENST00000511467, 
Fusion gene scores* DoF score12 X 11 X 7=9248 X 13 X 6=624
# samples 1415
** MAII scorelog2(14/924*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/624*10)=-2.05658352836637
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK10 [Title/Abstract] AND PTPN13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAPK10(87275683)-PTPN13(87679413), # samples:3
PTPN13(87515942)-MAPK10(87115560), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPN13

GO:0006470

protein dephosphorylation

17657516|19307596

TgenePTPN13

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

23604317


check buttonFusion gene breakpoints across MAPK10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTPN13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NA-A4QV-01AMAPK10chr4

87275683

-PTPN13chr4

87679413

+
ChimerDB4UCSTCGA-NA-A4QVMAPK10chr4

87275683

-PTPN13chr4

87679413

+


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Fusion Gene ORF analysis for MAPK10-PTPN13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000359221ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000359221ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000361569ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000361569ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000395161ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000395161ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000395166ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000395166ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000395169ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000395169ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000449047ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000449047ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000513839ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-3CDSENST00000513839ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000359221ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000359221ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000359221ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000359221ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000361569ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000361569ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000361569ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000361569ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395161ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395161ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395161ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395161ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395166ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395166ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395166ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395166ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395169ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395169ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395169ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000395169ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000449047ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000449047ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000449047ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000449047ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000513839ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000513839ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000513839ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
5UTR-intronENST00000513839ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-3CDSENST00000395157ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-3CDSENST00000395157ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-3CDSENST00000395160ENST00000427191MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-3CDSENST00000395160ENST00000436978MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395157ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395157ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395157ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395157ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395160ENST00000316707MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395160ENST00000411767MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395160ENST00000502971MAPK10chr4

87275683

-PTPN13chr4

87679413

+
intron-intronENST00000395160ENST00000511467MAPK10chr4

87275683

-PTPN13chr4

87679413

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAPK10-PTPN13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for MAPK10-PTPN13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:87275683/:87679413)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK10

P53779

PTPN13

PRY,PRY2

FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}.147

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAPK10-PTPN13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAPK10-PTPN13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAPK10-PTPN13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAPK10-PTPN13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource