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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MAPK1-SSU72 (FusionGDB2 ID:51549) |
Fusion Gene Summary for MAPK1-SSU72 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPK1-SSU72 | Fusion gene ID: 51549 | Hgene | Tgene | Gene symbol | MAPK1 | SSU72 | Gene ID | 5594 | 29101 |
| Gene name | mitogen-activated protein kinase 1 | SSU72 homolog, RNA polymerase II CTD phosphatase | |
| Synonyms | ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK | HSPC182|PNAS-120 | |
| Cytomap | 22q11.22 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72CTD phosphatase SSU72 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | P28482 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000215832, ENST00000398822, ENST00000544786, ENST00000491588, | ENST00000359060, ENST00000291386, | |
| Fusion gene scores | * DoF score | 20 X 16 X 10=3200 | 14 X 7 X 10=980 |
| # samples | 24 | 17 | |
| ** MAII score | log2(24/3200*10)=-3.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/980*10)=-2.52724700286487 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAPK1 [Title/Abstract] AND SSU72 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MAPK1(22221612)-SSU72(1480382), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MAPK1-SSU72 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. MAPK1-SSU72 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MAPK1-SSU72 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. MAPK1-SSU72 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPK1 | GO:0006468 | protein phosphorylation | 23184662 |
| Hgene | MAPK1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16314496 |
| Hgene | MAPK1 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| Hgene | MAPK1 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
| Hgene | MAPK1 | GO:0038127 | ERBB signaling pathway | 15133037 |
| Hgene | MAPK1 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
| Hgene | MAPK1 | GO:0070371 | ERK1 and ERK2 cascade | 16314496 |
| Hgene | MAPK1 | GO:0070849 | response to epidermal growth factor | 18794356 |
| Tgene | SSU72 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain | 20861839 |
| Fusion gene breakpoints across MAPK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SSU72 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LAML | TCGA-AB-2915-03A | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| ChimerDB4 | LUSC | TCGA-85-7697-01A | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| ChimerDB4 | LUSC | TCGA-85-7697 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| ChimerDB4 | LUSC | TCGA-85-7697 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
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Fusion Gene ORF analysis for MAPK1-SSU72 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000215832 | ENST00000359060 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| 5CDS-intron | ENST00000215832 | ENST00000359060 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| 5CDS-intron | ENST00000398822 | ENST00000359060 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| 5CDS-intron | ENST00000398822 | ENST00000359060 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| 5CDS-intron | ENST00000544786 | ENST00000359060 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| 5CDS-intron | ENST00000544786 | ENST00000359060 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| Frame-shift | ENST00000215832 | ENST00000291386 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| Frame-shift | ENST00000215832 | ENST00000291386 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| Frame-shift | ENST00000398822 | ENST00000291386 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| Frame-shift | ENST00000398822 | ENST00000291386 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| Frame-shift | ENST00000544786 | ENST00000291386 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| Frame-shift | ENST00000544786 | ENST00000291386 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| intron-3CDS | ENST00000491588 | ENST00000291386 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| intron-3CDS | ENST00000491588 | ENST00000291386 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| intron-3UTR | ENST00000215832 | ENST00000359060 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| intron-3UTR | ENST00000398822 | ENST00000359060 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| intron-3UTR | ENST00000491588 | ENST00000359060 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| intron-3UTR | ENST00000544786 | ENST00000359060 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| intron-intron | ENST00000215832 | ENST00000291386 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| intron-intron | ENST00000398822 | ENST00000291386 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| intron-intron | ENST00000491588 | ENST00000291386 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| intron-intron | ENST00000491588 | ENST00000359060 | MAPK1 | chr22 | 22221612 | - | SSU72 | chr1 | 1480382 | - |
| intron-intron | ENST00000491588 | ENST00000359060 | MAPK1 | chr22 | 22221611 | - | SSU72 | chr1 | 1480382 | - |
| intron-intron | ENST00000544786 | ENST00000291386 | MAPK1 | chr22 | 22115132 | - | SSU72 | chr1 | 1497956 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for MAPK1-SSU72 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for MAPK1-SSU72 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22221612/:1480382) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK1 | . |
| FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). {ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468, ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087, ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583, ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397, ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688, ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579, ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692, ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}.; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269|PubMed:19879846}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MAPK1-SSU72 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for MAPK1-SSU72 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MAPK1-SSU72 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MAPK1-SSU72 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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