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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAPK1-YDJC (FusionGDB2 ID:51551)

Fusion Gene Summary for MAPK1-YDJC

Fusion gene summary

Fusion gene information	Fusion gene name: MAPK1-YDJC
	Fusion gene ID: 51551
		Hgene	Tgene
	Gene symbol	MAPK1	YDJC
	Gene ID	5594	150223
	Gene name	mitogen-activated protein kinase 1	YdjC chitooligosaccharide deacetylase homolog
	Synonyms	ERK\|ERK-2\|ERK2\|ERT1\|MAPK2\|P42MAPK\|PRKM1\|PRKM2\|p38\|p40\|p41\|p41mapk\|p42-MAPK	-
	Cytomap	22q11.22	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2	carbohydrate deacetylaseUPF0249 protein ydjC homologYdjC homolog
	Modification date	20200327	20200320
	UniProtAcc	P28482	.
	Ensembl transtripts involved in fusion gene	ENST00000215832, ENST00000398822, ENST00000544786, ENST00000491588,	ENST00000292778, ENST00000398873,
Fusion gene scores	* DoF score	20 X 16 X 10=3200	1 X 1 X 1=1
	# samples	24	1
	** MAII score	log2(24/3200*10)=-3.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: MAPK1 [Title/Abstract] AND YDJC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAPK1(22221612)-YDJC(21983696), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAPK1	GO:0006468	protein phosphorylation	23184662
Hgene	MAPK1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	16314496
Hgene	MAPK1	GO:0018105	peptidyl-serine phosphorylation	15850461
Hgene	MAPK1	GO:0034198	cellular response to amino acid starvation	11096076
Hgene	MAPK1	GO:0038127	ERBB signaling pathway	15133037
Hgene	MAPK1	GO:0051403	stress-activated MAPK cascade	11096076
Hgene	MAPK1	GO:0070371	ERK1 and ERK2 cascade	16314496
Hgene	MAPK1	GO:0070849	response to epidermal growth factor	18794356

Fusion gene breakpoints across MAPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across YDJC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A8OQ-01A	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-

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Fusion Gene ORF analysis for MAPK1-YDJC

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000215832	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-
In-frame	ENST00000215832	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-
In-frame	ENST00000398822	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-
In-frame	ENST00000398822	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-
In-frame	ENST00000544786	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-
In-frame	ENST00000544786	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-
intron-3CDS	ENST00000491588	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-
intron-3CDS	ENST00000491588	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000215832	MAPK1	chr22	22221612	-	ENST00000292778	YDJC	chr22	21983696	-	1285	308	104	955	283
ENST00000215832	MAPK1	chr22	22221612	-	ENST00000398873	YDJC	chr22	21983696	-	1104	308	19	777	252
ENST00000398822	MAPK1	chr22	22221612	-	ENST00000292778	YDJC	chr22	21983696	-	1336	359	38	1006	322
ENST00000398822	MAPK1	chr22	22221612	-	ENST00000398873	YDJC	chr22	21983696	-	1155	359	70	828	252
ENST00000544786	MAPK1	chr22	22221612	-	ENST00000292778	YDJC	chr22	21983696	-	1096	119	161	766	201
ENST00000544786	MAPK1	chr22	22221612	-	ENST00000398873	YDJC	chr22	21983696	-	915	119	148	588	146

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000215832	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.40291193	0.59708804
ENST00000215832	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.28885064	0.71114933
ENST00000398822	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.46154806	0.5384519
ENST00000398822	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.2906936	0.7093064
ENST00000544786	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.46834335	0.5316566
ENST00000544786	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.37773857	0.6222614

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Fusion Genomic Features for MAPK1-YDJC

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAPK1-YDJC

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:22221612/chr22:21983696)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAPK1 P28482	.
FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). {ECO:0000250\|UniProtKB:P63086, ECO:0000269\|PubMed:10617468, ECO:0000269\|PubMed:10637505, ECO:0000269\|PubMed:11154262, ECO:0000269\|PubMed:12110590, ECO:0000269\|PubMed:12356731, ECO:0000269\|PubMed:12792650, ECO:0000269\|PubMed:12794087, ECO:0000269\|PubMed:12974390, ECO:0000269\|PubMed:15184391, ECO:0000269\|PubMed:15241487, ECO:0000269\|PubMed:15616583, ECO:0000269\|PubMed:15664191, ECO:0000269\|PubMed:15788397, ECO:0000269\|PubMed:15952796, ECO:0000269\|PubMed:16581800, ECO:0000269\|PubMed:18794356, ECO:0000269\|PubMed:19265199, ECO:0000269\|PubMed:19879846, ECO:0000269\|PubMed:22033920, ECO:0000269\|PubMed:7588608, ECO:0000269\|PubMed:8622688, ECO:0000269\|PubMed:9480836, ECO:0000269\|PubMed:9596579, ECO:0000269\|PubMed:9649500, ECO:0000269\|PubMed:9687510, ECO:0000303\|PubMed:15526160, ECO:0000303\|PubMed:16393692, ECO:0000303\|PubMed:19565474, ECO:0000303\|PubMed:21779493}.; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. {ECO:0000269\|PubMed:19879846}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

2_9

3486.3333333333335

Compositional bias

Note=Poly-Ala

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

2_9

361.0

Compositional bias

Note=Poly-Ala

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

2_9

317.0

Compositional bias

Note=Poly-Ala

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

31_39

3486.3333333333335

Nucleotide binding

ATP

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

31_39

361.0

Nucleotide binding

ATP

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

31_39

317.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

259_277

3486.3333333333335

DNA binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

259_277

361.0

DNA binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

259_277

317.0

DNA binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

25_313

3486.3333333333335

Domain

Protein kinase

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

25_313

361.0

Domain

Protein kinase

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

25_313

317.0

Domain

Protein kinase

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

185_187

3486.3333333333335

Motif

TXY

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

318_322

3486.3333333333335

Motif

Cytoplasmic retention motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

327_333

3486.3333333333335

Motif

Nuclear translocation motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

185_187

361.0

Motif

TXY

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

318_322

361.0

Motif

Cytoplasmic retention motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

327_333

361.0

Motif

Nuclear translocation motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

185_187

317.0

Motif

TXY

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

318_322

317.0

Motif

Cytoplasmic retention motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

327_333

317.0

Motif

Nuclear translocation motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

105_108

3486.3333333333335

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

153_154

3486.3333333333335

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

105_108

361.0

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

153_154

361.0

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

105_108

317.0

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

153_154

317.0

Region

Note=Inhibitor-binding

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Fusion Gene Sequence for MAPK1-YDJC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>51551_51551_1_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000215832_YDJC_chr22_21983696_ENST00000292778_length(transcript)=1285nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGTGCGGGAGGAGCTCGAGGCCCAACTAAGCTGCTTCCGGGAGCTGCTGGGCA
GGGCCCCCACGCACGCGGACGGGCACCAGCACGTGCACGTGCTCCCAGGCGTGTGCCAGGTGTTCGCCGAGGCGCTGCAGGCCTATGGGG
TGCGCTTTACGCGACTGCCGCTGGAGCGCGGTGTGGGTGGCTGCACTTGGCTGGAGGCCCCCGCGCGTGCCTTCGCCTGCGCCGTGGAGC
GCGACGCCCGGGCCGCCGTGGGCCCCTTCTCCCGCCACGGCCTGCGGTGGACAGACGCCTTCGTGGGCCTGAGCACTTGCGGCCGGCACA
TGTCCGCTCACCGCGTGTCCGGGGCCCTGGCGCGGGTCCTGGAAGGTACCCTAGCGGGCCACACCCTGACAGCCGAGCTGATGGCGCACC
CCGGCTACCCCAGTGTGCCTCCCACCGGCGGCTGCGGTGAAGGCCCCGACGCTTTCTCTTGCTCTTGGGAGCGGCTGCATGAGCTGCGCG
TCCTCACCGCGCCCACGCTGCGGGCCCAGCTTGCCCAGGATGGCGTGCAGCTTTGCGCCCTCGACGACCTGGACTCCAAGAGGCCAGGGG
AGGAGGTCCCCTGTGAGCCCACTCTGGAACCCTTCCTGGAACCCTCCCTACTCTGACCCCCTACAGACAACCAAGCACTAATCCCCTTAG
TACCAAGAAAGGGGAGCCAGGATTTAGTCCTGGCCCAGCCCAGAGCTGGGACCTGGAGCACGATCTGTTGACTTCCCTGGGTAGGACACT
GCCACCTCTGGGCTCAGGTCCTCATGCCTCCAAATGGCATCTAGAGTTTGAGCAGCCTTCTTGGCTGCAGGCAGGCCTAGCCTGTGGCAG
CGGGCTAGGGCCCGCAGAGCATTTGGTGCCCCTCCATGTTGCAATGCAAACACCTTCACCACTGGGGCAGTGGGGAGAGATGGCTATATT

>51551_51551_1_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000215832_YDJC_chr22_21983696_ENST00000292778_length(amino acids)=283AA_BP=1
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVVREELEAQLSCFRELLGRAPTH
ADGHQHVHVLPGVCQVFAEALQAYGVRFTRLPLERGVGGCTWLEAPARAFACAVERDARAAVGPFSRHGLRWTDAFVGLSTCGRHMSAHR
VSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCSWERLHELRVLTAPTLRAQLAQDGVQLCALDDLDSKRPGEEVPC

--------------------------------------------------------------
>51551_51551_2_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000215832_YDJC_chr22_21983696_ENST00000398873_length(transcript)=1104nt_BP=308nt
AGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTCCCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGG
CGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGAGCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCG
GCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAAC
CTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGGTGCGGGAGGAGCTCGAGGCCCAACTAAGCTGCTTCCGGGAGCTGCTGGGCA
GGGCCCCCACGCACGCGGACGGGCACCAGCACGTGCACGTGCTCCCAGGTGGACAGACGCCTTCGTGGGCCTGAGCACTTGCGGCCGGCA
CATGTCCGCTCACCGCGTGTCCGGGGCCCTGGCGCGGGTCCTGGAAGGTACCCTAGCGGGCCACACCCTGACAGCCGAGCTGATGGCGCA
CCCCGGCTACCCCAGTGTGCCTCCCACCGGCGGCTGCGGTGAAGGCCCCGACGCTTTCTCTTGCTCTTGGGAGCGGCTGCATGAGCTGCG
CGTCCTCACCGCGCCCACGCTGCGGGCCCAGCTTGCCCAGGATGGCGTGCAGCTTTGCGCCCTCGACGACCTGGACTCCAAGAGGCCAGG
GGAGGAGGTCCCCTGTGAGCCCACTCTGGAACCCTTCCTGGAACCCTCCCTACTCTGACCCCCTACAGACAACCAAGCACTAATCCCCTT
AGTACCAAGAAAGGGGAGCCAGGATTTAGTCCTGGCCCAGCCCAGAGCTGGGACCTGGAGCACGATCTGTTGACTTCCCTGGGTAGGACA
CTGCCACCTCTGGGCTCAGGTCCTCATGCCTCCAAATGGCATCTAGAGTTTGAGCAGCCTTCTTGGCTGCAGGCAGGCCTAGCCTGTGGC
AGCGGGCTAGGGCCCGCAGAGCATTTGGTGCCCCTCCATGTTGCAATGCAAACACCTTCACCACTGGGGCAGTGGGGAGAGATGGCTATA

>51551_51551_2_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000215832_YDJC_chr22_21983696_ENST00000398873_length(amino acids)=252AA_BP=1
MSALQLSRSASSFLLPVSVGGCTGGGAVPAGGATRAERRPPSVELSAAEAAAARQPTWRRRRRRARARRWSAGRCSTWGRATPTSRTSAR
APTAWCGAGGARGPTKLLPGAAGQGPHARGRAPARARAPRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSV

--------------------------------------------------------------
>51551_51551_3_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000398822_YDJC_chr22_21983696_ENST00000292778_length(transcript)=1336nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
TGCGGGAGGAGCTCGAGGCCCAACTAAGCTGCTTCCGGGAGCTGCTGGGCAGGGCCCCCACGCACGCGGACGGGCACCAGCACGTGCACG
TGCTCCCAGGCGTGTGCCAGGTGTTCGCCGAGGCGCTGCAGGCCTATGGGGTGCGCTTTACGCGACTGCCGCTGGAGCGCGGTGTGGGTG
GCTGCACTTGGCTGGAGGCCCCCGCGCGTGCCTTCGCCTGCGCCGTGGAGCGCGACGCCCGGGCCGCCGTGGGCCCCTTCTCCCGCCACG
GCCTGCGGTGGACAGACGCCTTCGTGGGCCTGAGCACTTGCGGCCGGCACATGTCCGCTCACCGCGTGTCCGGGGCCCTGGCGCGGGTCC
TGGAAGGTACCCTAGCGGGCCACACCCTGACAGCCGAGCTGATGGCGCACCCCGGCTACCCCAGTGTGCCTCCCACCGGCGGCTGCGGTG
AAGGCCCCGACGCTTTCTCTTGCTCTTGGGAGCGGCTGCATGAGCTGCGCGTCCTCACCGCGCCCACGCTGCGGGCCCAGCTTGCCCAGG
ATGGCGTGCAGCTTTGCGCCCTCGACGACCTGGACTCCAAGAGGCCAGGGGAGGAGGTCCCCTGTGAGCCCACTCTGGAACCCTTCCTGG
AACCCTCCCTACTCTGACCCCCTACAGACAACCAAGCACTAATCCCCTTAGTACCAAGAAAGGGGAGCCAGGATTTAGTCCTGGCCCAGC
CCAGAGCTGGGACCTGGAGCACGATCTGTTGACTTCCCTGGGTAGGACACTGCCACCTCTGGGCTCAGGTCCTCATGCCTCCAAATGGCA
TCTAGAGTTTGAGCAGCCTTCTTGGCTGCAGGCAGGCCTAGCCTGTGGCAGCGGGCTAGGGCCCGCAGAGCATTTGGTGCCCCTCCATGT

>51551_51551_3_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000398822_YDJC_chr22_21983696_ENST00000292778_length(amino acids)=322AA_BP=1
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVVREELEAQLSCFRELLGRAPTHADGHQHVHVLPGVCQVFAEALQAYGVRFTRLPLERGVGGCTWLEAPARAFA
CAVERDARAAVGPFSRHGLRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCSWERL

--------------------------------------------------------------
>51551_51551_4_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000398822_YDJC_chr22_21983696_ENST00000398873_length(transcript)=1155nt_BP=359nt
GCCCCTCCCTCCGCCCGCCCGCCGGCCCGCCCGTCAGTCTGGCAGGCAGGCAGGCAATCGGTCCGAGTGGCTGTCGGCTCTTCAGCTCTC
CCGCTCGGCGTCTTCCTTCCTCCTCCCGGTCAGCGTCGGCGGCTGCACCGGCGGCGGCGCAGTCCCTGCGGGAGGGGCGACAAGAGCTGA
GCGGCGGCCGCCGAGCGTCGAGCTCAGCGCGGCGGAGGCGGCGGCGGCCCGGCAGCCAACATGGCGGCGGCGGCGGCGGCGGGCGCGGGC
CCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTACATCGGCGAGGGCGCCTACGGCATGGTGTGG
TGCGGGAGGAGCTCGAGGCCCAACTAAGCTGCTTCCGGGAGCTGCTGGGCAGGGCCCCCACGCACGCGGACGGGCACCAGCACGTGCACG
TGCTCCCAGGTGGACAGACGCCTTCGTGGGCCTGAGCACTTGCGGCCGGCACATGTCCGCTCACCGCGTGTCCGGGGCCCTGGCGCGGGT
CCTGGAAGGTACCCTAGCGGGCCACACCCTGACAGCCGAGCTGATGGCGCACCCCGGCTACCCCAGTGTGCCTCCCACCGGCGGCTGCGG
TGAAGGCCCCGACGCTTTCTCTTGCTCTTGGGAGCGGCTGCATGAGCTGCGCGTCCTCACCGCGCCCACGCTGCGGGCCCAGCTTGCCCA
GGATGGCGTGCAGCTTTGCGCCCTCGACGACCTGGACTCCAAGAGGCCAGGGGAGGAGGTCCCCTGTGAGCCCACTCTGGAACCCTTCCT
GGAACCCTCCCTACTCTGACCCCCTACAGACAACCAAGCACTAATCCCCTTAGTACCAAGAAAGGGGAGCCAGGATTTAGTCCTGGCCCA
GCCCAGAGCTGGGACCTGGAGCACGATCTGTTGACTTCCCTGGGTAGGACACTGCCACCTCTGGGCTCAGGTCCTCATGCCTCCAAATGG
CATCTAGAGTTTGAGCAGCCTTCTTGGCTGCAGGCAGGCCTAGCCTGTGGCAGCGGGCTAGGGCCCGCAGAGCATTTGGTGCCCCTCCAT

>51551_51551_4_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000398822_YDJC_chr22_21983696_ENST00000398873_length(amino acids)=252AA_BP=1
MSALQLSRSASSFLLPVSVGGCTGGGAVPAGGATRAERRPPSVELSAAEAAAARQPTWRRRRRRARARRWSAGRCSTWGRATPTSRTSAR
APTAWCGAGGARGPTKLLPGAAGQGPHARGRAPARARAPRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSV

--------------------------------------------------------------
>51551_51551_5_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000544786_YDJC_chr22_21983696_ENST00000292778_length(transcript)=1096nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGTGCGGGAGGAGCTCGAGGCCCAACTAAGCTGCTTCCGGGAGCTGCTGGGCAGGGCCCCCA
CGCACGCGGACGGGCACCAGCACGTGCACGTGCTCCCAGGCGTGTGCCAGGTGTTCGCCGAGGCGCTGCAGGCCTATGGGGTGCGCTTTA
CGCGACTGCCGCTGGAGCGCGGTGTGGGTGGCTGCACTTGGCTGGAGGCCCCCGCGCGTGCCTTCGCCTGCGCCGTGGAGCGCGACGCCC
GGGCCGCCGTGGGCCCCTTCTCCCGCCACGGCCTGCGGTGGACAGACGCCTTCGTGGGCCTGAGCACTTGCGGCCGGCACATGTCCGCTC
ACCGCGTGTCCGGGGCCCTGGCGCGGGTCCTGGAAGGTACCCTAGCGGGCCACACCCTGACAGCCGAGCTGATGGCGCACCCCGGCTACC
CCAGTGTGCCTCCCACCGGCGGCTGCGGTGAAGGCCCCGACGCTTTCTCTTGCTCTTGGGAGCGGCTGCATGAGCTGCGCGTCCTCACCG
CGCCCACGCTGCGGGCCCAGCTTGCCCAGGATGGCGTGCAGCTTTGCGCCCTCGACGACCTGGACTCCAAGAGGCCAGGGGAGGAGGTCC
CCTGTGAGCCCACTCTGGAACCCTTCCTGGAACCCTCCCTACTCTGACCCCCTACAGACAACCAAGCACTAATCCCCTTAGTACCAAGAA
AGGGGAGCCAGGATTTAGTCCTGGCCCAGCCCAGAGCTGGGACCTGGAGCACGATCTGTTGACTTCCCTGGGTAGGACACTGCCACCTCT
GGGCTCAGGTCCTCATGCCTCCAAATGGCATCTAGAGTTTGAGCAGCCTTCTTGGCTGCAGGCAGGCCTAGCCTGTGGCAGCGGGCTAGG
GCCCGCAGAGCATTTGGTGCCCCTCCATGTTGCAATGCAAACACCTTCACCACTGGGGCAGTGGGGAGAGATGGCTATATTAATAAAATA

>51551_51551_5_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000544786_YDJC_chr22_21983696_ENST00000292778_length(amino acids)=201AA_BP=
MLGRAPTHADGHQHVHVLPGVCQVFAEALQAYGVRFTRLPLERGVGGCTWLEAPARAFACAVERDARAAVGPFSRHGLRWTDAFVGLSTC
GRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCSWERLHELRVLTAPTLRAQLAQDGVQLCALDDLDSK

--------------------------------------------------------------
>51551_51551_6_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000544786_YDJC_chr22_21983696_ENST00000398873_length(transcript)=915nt_BP=119nt
ATGGCGGCGGCGGCGGCGGCGGGCGCGGGCCCGGAGATGGTCCGCGGGCAGGTGTTCGACGTGGGGCCGCGCTACACCAACCTCTCGTAC
ATCGGCGAGGGCGCCTACGGCATGGTGTGGTGCGGGAGGAGCTCGAGGCCCAACTAAGCTGCTTCCGGGAGCTGCTGGGCAGGGCCCCCA
CGCACGCGGACGGGCACCAGCACGTGCACGTGCTCCCAGGTGGACAGACGCCTTCGTGGGCCTGAGCACTTGCGGCCGGCACATGTCCGC
TCACCGCGTGTCCGGGGCCCTGGCGCGGGTCCTGGAAGGTACCCTAGCGGGCCACACCCTGACAGCCGAGCTGATGGCGCACCCCGGCTA
CCCCAGTGTGCCTCCCACCGGCGGCTGCGGTGAAGGCCCCGACGCTTTCTCTTGCTCTTGGGAGCGGCTGCATGAGCTGCGCGTCCTCAC
CGCGCCCACGCTGCGGGCCCAGCTTGCCCAGGATGGCGTGCAGCTTTGCGCCCTCGACGACCTGGACTCCAAGAGGCCAGGGGAGGAGGT
CCCCTGTGAGCCCACTCTGGAACCCTTCCTGGAACCCTCCCTACTCTGACCCCCTACAGACAACCAAGCACTAATCCCCTTAGTACCAAG
AAAGGGGAGCCAGGATTTAGTCCTGGCCCAGCCCAGAGCTGGGACCTGGAGCACGATCTGTTGACTTCCCTGGGTAGGACACTGCCACCT
CTGGGCTCAGGTCCTCATGCCTCCAAATGGCATCTAGAGTTTGAGCAGCCTTCTTGGCTGCAGGCAGGCCTAGCCTGTGGCAGCGGGCTA
GGGCCCGCAGAGCATTTGGTGCCCCTCCATGTTGCAATGCAAACACCTTCACCACTGGGGCAGTGGGGAGAGATGGCTATATTAATAAAA

>51551_51551_6_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000544786_YDJC_chr22_21983696_ENST00000398873_length(amino acids)=146AA_BP=
MLPGAAGQGPHARGRAPARARAPRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MAPK1-YDJC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MAPK1-YDJC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MAPK1-YDJC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source