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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAPK9-ITPR1 (FusionGDB2 ID:51581)

Fusion Gene Summary for MAPK9-ITPR1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK9-ITPR1
Fusion gene ID: 51581
HgeneTgene
Gene symbol

MAPK9

ITPR1

Gene ID

5601

3708

Gene namemitogen-activated protein kinase 9inositol 1,4,5-trisphosphate receptor type 1
SynonymsJNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPKACV|CLA4|INSP3R1|IP3R|IP3R1|PPP1R94|SCA15|SCA16|SCA29
Cytomap

5q35.3

3p26.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 9Jun kinaseMAP kinase 9MAPK 9c-Jun N-terminal kinase 2c-Jun kinase 2stress-activated protein kinase 1astress-activated protein kinase JNK2inositol 1,4,5-trisphosphate receptor type 1IP3 receptorIP3R 1inositol 1,4,5-triphosphate receptor, type 1protein phosphatase 1, regulatory subunit 94type 1 InsP3 receptortype 1 inositol 1,4,5-trisphosphate receptor
Modification date2020032720200327
UniProtAcc

P45984

Q14643

Ensembl transtripts involved in fusion geneENST00000343111, ENST00000347470, 
ENST00000393360, ENST00000397072, 
ENST00000425491, ENST00000452135, 
ENST00000455781, ENST00000524170, 
ENST00000539014, 		ENST00000302640, 
ENST00000354582, ENST00000357086, 
ENST00000423119, ENST00000456211, 
ENST00000443694, ENST00000463980, 
ENST00000544951, 
Fusion gene scores* DoF score9 X 10 X 6=5409 X 13 X 8=936
# samples 1016
** MAII scorelog2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/936*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK9 [Title/Abstract] AND ITPR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAPK9(179660926)-ITPR1(4752029), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK9

GO:0007254

JNK cascade

8654373

HgeneMAPK9

GO:0018105

peptidyl-serine phosphorylation

21856198

TgeneITPR1

GO:0001666

response to hypoxia

19120137

TgeneITPR1

GO:0050849

negative regulation of calcium-mediated signaling

16793548


check buttonFusion gene breakpoints across MAPK9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ITPR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI096773MAPK9chr5

179660926

+ITPR1chr3

4752029

-
ChiTaRS5.0N/AAI361133MAPK9chr5

179660926

+ITPR1chr3

4752029

-
ChiTaRS5.0N/AAI363310MAPK9chr5

179660926

+ITPR1chr3

4752029

-


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Fusion Gene ORF analysis for MAPK9-ITPR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000343111ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000343111ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000343111ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000343111ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000343111ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000347470ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000347470ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000347470ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000347470ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000347470ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000393360ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000393360ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000393360ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000393360ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000393360ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000397072ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000397072ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000397072ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000397072ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000397072ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000425491ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000425491ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000425491ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000425491ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000425491ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000452135ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000452135ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000452135ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000452135ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000452135ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000455781ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000455781ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000455781ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000455781ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000455781ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000524170ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000524170ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000524170ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000524170ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000524170ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000539014ENST00000302640MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000539014ENST00000354582MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000539014ENST00000357086MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000539014ENST00000423119MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-3CDSENST00000539014ENST00000456211MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000343111ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000343111ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000343111ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000347470ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000347470ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000347470ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000393360ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000393360ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000393360ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000397072ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000397072ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000397072ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000425491ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000425491ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000425491ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000452135ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000452135ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000452135ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000455781ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000455781ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000455781ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000524170ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000524170ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000524170ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000539014ENST00000443694MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000539014ENST00000463980MAPK9chr5

179660926

+ITPR1chr3

4752029

-
intron-intronENST00000539014ENST00000544951MAPK9chr5

179660926

+ITPR1chr3

4752029

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAPK9-ITPR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAPK9-ITPR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:179660926/:4752029)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK9

P45984

ITPR1

Q14643

FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9WTU6, ECO:0000269|PubMed:22441692}.; FUNCTION: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250|UniProtKB:P11881, ECO:0000269|PubMed:27108797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAPK9-ITPR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAPK9-ITPR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAPK9-ITPR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAPK9-ITPR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource