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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MAPKAP1-DENND1A (FusionGDB2 ID:51592)

Fusion Gene Summary for MAPKAP1-DENND1A

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPKAP1-DENND1A
Fusion gene ID: 51592
HgeneTgene
Gene symbol

MAPKAP1

DENND1A

Gene ID

79109

57706

Gene nameMAPK associated protein 1DENN domain containing 1A
SynonymsJC310|MIP1|SIN1|SIN1b|SIN1gFAM31A|KIAA1608
Cytomap

9q33.3

9q33.3

Type of geneprotein-codingprotein-coding
Descriptiontarget of rapamycin complex 2 subunit MAPKAP1MEKK2-interacting protein 1SAPK-interacting protein 1TORC2 subunit MAPKAP1mSIN1mitogen-activated protein kinase 2-associated protein 1mitogen-activated protein kinase associated protein 1ras inhibitor MGDENN domain-containing protein 1ADENN/MADD domain containing 1Aconnecdenn 1
Modification date2020032920200320
UniProtAcc

Q9BPZ7

Q8TEH3

Ensembl transtripts involved in fusion geneENST00000265960, ENST00000350766, 
ENST00000373503, ENST00000373511, 
ENST00000394060, ENST00000394063, 
ENST00000373497, ENST00000373498, 
ENST00000483937, 		ENST00000373624, 
ENST00000473039, ENST00000373618, 
ENST00000373620, ENST00000394215, 
ENST00000394219, ENST00000542603, 
Fusion gene scores* DoF score16 X 13 X 8=166422 X 22 X 12=5808
# samples 1633
** MAII scorelog2(16/1664*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/5808*10)=-4.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPKAP1 [Title/Abstract] AND DENND1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointMAPKAP1(128469250)-DENND1A(126554909), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDENND1A

GO:0032483

regulation of Rab protein signal transduction

20937701


check buttonFusion gene breakpoints across MAPKAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DENND1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-A45T-01AMAPKAP1chr9

128469250

-DENND1Achr9

126554909

-


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Fusion Gene ORF analysis for MAPKAP1-DENND1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000265960ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000265960ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000350766ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000350766ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000373503ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000373503ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000373511ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000373511ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000394060ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000394060ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000394063ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-5UTRENST00000394063ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000265960ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000265960ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000265960ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000265960ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000265960ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000350766ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000350766ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000350766ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000350766ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000350766ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373503ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373503ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373503ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373503ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373503ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373511ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373511ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373511ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373511ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000373511ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394060ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394060ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394060ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394060ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394060ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394063ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394063ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394063ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394063ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
5UTR-intronENST00000394063ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-5UTRENST00000373497ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-5UTRENST00000373497ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-5UTRENST00000373498ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-5UTRENST00000373498ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-5UTRENST00000483937ENST00000373624MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-5UTRENST00000483937ENST00000473039MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373497ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373497ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373497ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373497ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373497ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373498ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373498ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373498ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373498ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000373498ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000483937ENST00000373618MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000483937ENST00000373620MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000483937ENST00000394215MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000483937ENST00000394219MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-
intron-intronENST00000483937ENST00000542603MAPKAP1chr9

128469250

-DENND1Achr9

126554909

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for MAPKAP1-DENND1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAPKAP1-DENND1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:128469250/:126554909)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPKAP1

Q9BPZ7

DENND1A

Q8TEH3

FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. {ECO:0000269|PubMed:15988011, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:17043309, ECO:0000269|PubMed:17054722, ECO:0000269|PubMed:17303383, ECO:0000269|PubMed:23727834}.FUNCTION: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). {ECO:0000250|UniProtKB:Q8K382, ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for MAPKAP1-DENND1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for MAPKAP1-DENND1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MAPKAP1-DENND1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MAPKAP1-DENND1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource