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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:MAPKAPK2-SRGAP2 (FusionGDB2 ID:51612)

Fusion Gene Summary for MAPKAPK2-SRGAP2

Fusion gene summary

Fusion gene information	Fusion gene name: MAPKAPK2-SRGAP2
	Fusion gene ID: 51612
		Hgene	Tgene
	Gene symbol	MAPKAPK2	SRGAP2
	Gene ID	9261	23380
	Gene name	MAPK activated protein kinase 2	SLIT-ROBO Rho GTPase activating protein 2
	Synonyms	MAPKAP-K2\|MK-2\|MK2	ARHGAP34\|FNBP2\|SRGAP2A\|SRGAP3
	Cytomap	1q32.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	MAP kinase-activated protein kinase 2MAPKAP kinase 2mitogen-activated protein kinase-activated protein kinase 2	SLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000294981, ENST00000367103, ENST00000479009,	ENST00000419187, ENST00000471256, ENST00000414007,
Fusion gene scores	* DoF score	8 X 6 X 5=240	15 X 15 X 7=1575
	# samples	8	16
	** MAII score	log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1575*10)=-3.29920801838728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MAPKAPK2 [Title/Abstract] AND SRGAP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	MAPKAPK2(206858853)-SRGAP2(206589249), # samples:2 SRGAP2(206135293)-MAPKAPK2(206904483), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAPKAPK2	GO:0018105	peptidyl-serine phosphorylation	15850461
Hgene	MAPKAPK2	GO:0032680	regulation of tumor necrosis factor production	15014438
Hgene	MAPKAPK2	GO:0034097	response to cytokine	8774846
Hgene	MAPKAPK2	GO:0070935	3'-UTR-mediated mRNA stabilization	14517288\|15014438\|20932473
Tgene	SRGAP2	GO:0043547	positive regulation of GTPase activity	21148482
Tgene	SRGAP2	GO:0046847	filopodium assembly	22559944
Tgene	SRGAP2	GO:0051014	actin filament severing	21148482
Tgene	SRGAP2	GO:0060996	dendritic spine development	22559944
Tgene	SRGAP2	GO:2001223	negative regulation of neuron migration	22559944

Fusion gene breakpoints across MAPKAPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SRGAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-5435-01A	MAPKAPK2	chr1	206858853	-	SRGAP2	chr1	206589249	+
ChimerDB4	HNSC	TCGA-CV-5435	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+

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Fusion Gene ORF analysis for MAPKAPK2-SRGAP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000294981	ENST00000419187	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
5CDS-5UTR	ENST00000367103	ENST00000419187	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
5CDS-intron	ENST00000294981	ENST00000471256	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
5CDS-intron	ENST00000367103	ENST00000471256	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
In-frame	ENST00000294981	ENST00000414007	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
In-frame	ENST00000367103	ENST00000414007	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
intron-3CDS	ENST00000479009	ENST00000414007	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
intron-5UTR	ENST00000479009	ENST00000419187	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+
intron-intron	ENST00000479009	ENST00000471256	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000294981

MAPKAPK2

chr1

206858853

ENST00000414007

SRGAP2

chr1

206589249

5443

565

142

2424

760

ENST00000367103

MAPKAPK2

chr1

206858853

ENST00000414007

SRGAP2

chr1

206589249

5350

472

2331

760

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000294981	ENST00000414007	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+	0.001428217	0.99857175
ENST00000367103	ENST00000414007	MAPKAPK2	chr1	206858853	+	SRGAP2	chr1	206589249	+	0.001458517	0.9985415

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Fusion Genomic Features for MAPKAPK2-SRGAP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for MAPKAPK2-SRGAP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:206858853/chr1:206589249)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

10_40

371.0

Compositional bias

Note=Pro-rich

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

35_40

371.0

Compositional bias

Note=Poly-Pro

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

10_40

401.0

Compositional bias

Note=Pro-rich

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

35_40

401.0

Compositional bias

Note=Poly-Pro

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

70_78

371.0

Nucleotide binding

ATP

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

70_78

401.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

64_325

371.0

Domain

Protein kinase

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

64_325

401.0

Domain

Protein kinase

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

356_365

371.0

Motif

Note=Nuclear export signal (NES)

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

371_374

371.0

Motif

Note=Bipartite nuclear localization signal 1

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

385_389

371.0

Motif

Note=Bipartite nuclear localization signal 2

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

356_365

401.0

Motif

Note=Nuclear export signal (NES)

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

371_374

401.0

Motif

Note=Bipartite nuclear localization signal 1

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

385_389

401.0

Motif

Note=Bipartite nuclear localization signal 2

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

139_141

371.0

Region

Note=Staurosporine binding

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

328_364

371.0

Region

Autoinhibitory helix

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000294981

366_390

371.0

Region

Note=p38 MAPK-binding site

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

139_141

401.0

Region

Note=Staurosporine binding

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

328_364

401.0

Region

Autoinhibitory helix

Hgene

MAPKAPK2

chr1:206858853

chr1:206589249

ENST00000367103

366_390

401.0

Region

Note=p38 MAPK-binding site

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Fusion Gene Sequence for MAPKAPK2-SRGAP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>51612_51612_1_MAPKAPK2-SRGAP2_MAPKAPK2_chr1_206858853_ENST00000294981_SRGAP2_chr1_206589249_ENST00000414007_length(transcript)=5443nt_BP=565nt
GCGGCCGCTTCCCCCCGGCCGGGCCCCCGCCGCCCCGCGGTCCCCAGAGCGCCAGGCCCCCGGGGGGAGGGAGGGAGGGCGCCGGGCCGG
TGGGAGCCAGCGGCGCGCGGTGGGACCCACGGAGCCCCGCGACCCGCCGAGCCTGGAGCCGGGCCGGGTCGGGGAAGCCGGCTCCAGCCC
GGAGCGAACTTCGCAGCCCGTCGGGGGGCGGCGGGGAGGGGGCCCGGAGCCGGAGGAGGGGGCGGCCGCGGGCACCCCCGCCTGTGCCCC
GGCGTCCCCGGGCACCATGCTGTCCAACTCCCAGGGCCAGAGCCCGCCGGTGCCGTTCCCCGCCCCGGCCCCGCCGCCGCAGCCCCCCAC
CCCTGCCCTGCCGCACCCCCCGGCGCAGCCGCCGCCGCCGCCCCCGCAGCAGTTCCCGCAGTTCCACGTCAAGTCCGGCCTGCAGATCAA
GAAGAACGCCATCATCGATGACTACAAGGTCACCAGCCAGGTCCTGGGGCTGGGCATCAACGGCAAAGTTTTGCAGATCTTCAACAAGAG
GACCCAGGAGAAATTCGCCCTCAAAAAAATGAAAGAGTACCTGGAGGGCAGGAACCTCATCACCAAGTTACAAGCCAAGCATGACCTTCT
GCAGAAAACCCTGGGAGAAAGTCAGCGGACAGATTGCAGTCTAGCCAGGCGCAGCTCAACTGTGAGGAAACAGGACTCCAGCCAGGCAAT
TCCTCTGGTGGTGGAAAGCTGTATCCGGTTTATCAGCAGACACGGACTACAGCATGAAGGAATTTTCCGGGTGTCAGGATCCCAGGTGGA
AGTGAATGACATCAAAAATGCCTTTGAGAGAGGAGAGGACCCCCTGGCTGGGGACCAGAACGACCATGACATGGATTCCATAGCTGGTGT
CCTGAAGCTTTACTTCCGGGGGCTGGAACACCCTCTCTTCCCCAAGGACATCTTTCATGACCTGATGGCCTGCGTCACAATGGACAACCT
GCAGGAGAGAGCTCTGCACATCCGGAAAGTCCTCCTAGTCCTGCCCAAAACCACTCTGATTATCATGAGATACCTCTTTGCCTTCCTCAA
TCATTTATCACAGTTCAGTGAAGAGAACATGATGGACCCCTACAACCTCGCCATCTGCTTCGGGCCCTCGCTAATGTCAGTGCCAGAGGG
CCACGACCAGGTGTCCTGCCAAGCCCACGTGAATGAGCTGATCAAAACCATCATCATCCAGCATGAGAACATCTTCCCAAGCCCCAGGGA
GCTGGAGGGCCCTGTCTACAGCAGAGGAGGAAGCATGGAGGATTACTGTGATAGCCCTCATGGAGAGACTACCTCGGTTGAAGACTCAAC
CCAGGATGTGACCGCAGAGCACCACACGAGCGATGACGAATGTGAGCCCATCGAGGCCATTGCCAAGTTTGACTACGTGGGCCGGACAGC
CCGAGAGCTGTCCTTTAAGAAGGGAGCATCCCTGCTGCTTTACCAGCGGGCTTCCGACGACTGGTGGGAAGGCCGGCACAATGGCATCGA
CGGACTCATCCCCCATCAGTACATCGTGGTCCAAGACACCGAGGACGGTGTCGTGGAGAGGTCCAGCCCCAAGTCTGAGATTGAGGTCAT
TTCTGAGCCACCTGAAGAAAAGGTGACAGCCAGAGCGGGGGCCAGCTGTCCCAGTGGGGGTCATGTAGCCGATATTTATCTTGCAAACAT
CAACAAGCAAAGGAAGCGTCCAGAATCTGGGAGCATCCGGAAAACTTTTCGGAGTGACAGCCATGGGCTGAGCAGTTCCCTGACTGACTC
CTCCTCCCCAGGGGTGGGGGCTAGCTGCCGCCCATCCTCCCAGCCCATCATGAGCCAGAGCCTCCCCAAAGAAGGGCCAGATAAGTGTTC
CATCAGTGGGCACGGGAGCCTCAACTCCATCAGCCGCCACTCATCCCTGAAGAATCGGCTGGATAGTCCACAGATCCGGAAGACTGCCAC
AGCGGGAAGGTCAAAAAGCTTCAATAACCATCGGCCCATGGACCCTGAGGTCATTGCTCAGGATATTGAGGCAACAATGAACTCGGCCCT
GAATGAGCTACGGGAACTAGAACGGCAGAGCAGTGTCAAACACACCCCTGACGTGGTTCTGGACACCTTGGAGCCCCTCAAAACCTCCCC
AGTGGTGGCCCCCACGTCAGAGCCCTCCAGCCCTCTGCACACCCAGCTCCTCAAGGACCCCGAGCCCGCCTTCCAGCGCAGCGCCAGTAC
TGCTGGGGACATCGCCTGCGCCTTCCGGCCTGTCAAGTCTGTCAAGATGGCTGCCCCGGTCAAACCACCAGCCACACGGCCCAAGCCCAC
TGTCTTCCCCAAAACAAATGCCACTAGCCCTGGTGTCAACTCATCAACTTCCCCACAGTCTACTGACAAGTCTTGTACTGTCTGAGGGAT
AATAATTTAATTGTTCTAGACAAGGGGACTATAGGGACTGACTGTTATTAAAATCTTCCTATTTAACTAGCTTGGGGACTTCAGTTGAAA
ATTAGGTTCTAAGTTGTTCTTGCAGGAATTAGCCTCCCCGTCTCCCAAAACCTTGAGAATGAAGCCCTTGGTATCGCCTCTCCCTTCCCA
CTGCCCTCTGCTTCCCCCAGTCGTCGTAATTCAGCCAGCTGCAGTCCGTACCGTTCTTAGGTTAGCCAGAGACAGGTTTTCATTATCAGG
TCACTGTGAAATCTGGTAAGGCAGTCCTGAGGACATGGGCTCAAGTCTCAGTCCCCTCAGACCACGGTGATGCCTTGACCAGATGGTTGG
CTACTGCCATCCAGCTTTCAGTGGCATCTTGTTTTGGGAACTGATTATAGAGAATCATATATAGTCCAGTCTTCATTTTACATACACACA
CATATTTTACACACACACACATTTTACACACACACACACACACACACACATATGTTTTTCTAGTCTCTGGCATGTGTAGCCTCTCCTGGT
CATAGACCAGTCTCTTTGTAAGTTATTGTGGCAGTTCACACAGTAGCCACCAGGGGTCTCTGTTTCCATTACAAACTTTGTTCTGTCTGG
GCCAGAGAACCTAGCCTTTGAAATCTCTCCATCATATGAAACATAACGGGATGGGACAATCCCGTAACCTGTTTGGGGTTGGGGGCTTTC
TCTCTGTGTTCTTTCCATTGATGTGAATTGGTCATTGGTGTTTGCTCTTGCCTCTCCTCCATCCCCTAGAAGTACACCCCCGTCTTATTA
AGGAGCTTTTAAAGTTTTTCTGAATGTATAGACATTTCTCGGGTTCCTACCTTTGTCTCTGATGGACCATTTTCCATTTAAGACATTTTC
CTGTATAAGACAGTTTTATAGCTGGTTCCTTTTAGGGTAAAGAGTCTTAAGAGAGTTTTATTGTGTCTATGGCAGGTTTGGGAAAGGTAA
GAAATGGGTCCTTTTTCCTCCTAATGTTTTTGGCACTTAAAACATAAAATTCATTATCCTATTAAAAAATTAAATTCAGCTTTGCTAATC
CAGAAATTGTTCCCAAATGAAAACTTGTTTTAAGTCCACCCCTTAGTTTCCTTATTTTACAAGGTCTCTCTTCAGGGACCAACAGGGGCT
TAGAGAGCCTTAGTTAGATTAAAGGGAGACCCTACCTCTTAAAACCAGTTTTCATTTATGCAAACAAGGACAATTAAGGGAACCCTGACC
CCACAGGCTCTCAAGTCTTCCCAAGGCCAGAATCGAAAGAAAATTAAAATTTGAATGCTGAATATTCTGGCTCTACTCTGGCCTTTTTTC
TGGTTCCCTTCCAAAATGCACAAATCATACCCTTGTCTGCTCCAATTCAGTCTCCAAACCTGGTGCCTGTGCTCCTGGCCCCCCTAGCAT
CATGCTATCCCAGGAGTATCAGGACCAGACACATCCACAGCCAGGCTCATGGGTCTCAGACAGCAACTTGAGTTAAAGCTGAAACTCATC
CTTCTTCTCTGTGTTTTCTGGTTTAAAAGCTGCACTTATATTTTAGCCTTATTATTTTCTGTAGTTCCGGAGAGATGGTGGGTTGCCATT
CTGGTAGGAAAATCTGAGTTTTCTTATCTTTGACCTAGAAGAGATTCTTTTTGGACCAACCTGCGAAATTGGTAGTTAGGTCTATGGAAA
GTGGTAGGATTTTTTTTTTTTAATCCTGTGCAAAGGAAAAGAGGTGCTTTGTGGGAAATCACTAATGAGAAGGCTAACCTGCAGCACCAG
AGAAACCTTTCCAAGTGCTAGGCAGGAGAACTGAAGAACTCTTTCAGTGAAGTGAGTCAGCCTAGAAGAGGCAACCCACAGTCTTGATTT
TTGTTGCTGTTTCCTGACCTGTTCTTGCCTGTCACCTGGGCCTACACAGGTCCCGAGCCAACGGGGCTTTCATACCCAAGGATCTGTTTC
CTTGCTGAAAATGAAACCCTATCTTTCACTTTACATTCCTTTCAATCCAACTGATCAAAACTGGTACCCACACTTGCCCTTTCTCCCTCT
CTCCAGCACACTCCCCTCTAAGAAAGTAAAAGCAAAGCTTTCTTAATGGCAACACTTTGGGCCTGTTCTGTTGCTCCTGCCTTATTTCTC
TTTCAACCCTGTACATGACTCGTGTTCACCATCCCCTTGATCAGTGTCCATCCGCGCTAATTTGCATCATGAACTGAACAGTGTGTGAGT
GGTCACCTACTAAACCCAGCTCTGGGGGCAGAGCTGTCTTCCCCATCTCTGGTGCTCCTAACACCTGTGAGATGGTCCTGTCGAGAGGAC
TAGGAACCGATAGGAGGAGAGTCCTTCTCGGCAGAGCTCACTGCAAACAACTGGAATTGAGGTTGCACACTGTGATTTTTACACCGAAAA
GCCAAAAGGAGCTGGCCATCCAGGGCCTAGGGAGACCAGCCTTCCTCAGCTATGCTTGCCGAAACCAGCATGATGCTTCAAAGAGCCCTG
CTCCACCCCTCATGGCATGGATCCTTTTCCTGGTGTGGACTCTGAAGGGTCAGTCTTCGGGGAAGAGAGGTGGGGTGGGGCTACTAGCAT
CCCAATTTAGAAAACAGAGGAGTTTGTAGCCAGCAGCCTGTAAACTGGAAACACTGGTCTCAGCCAACCTCCTCAGGGCGCCCTGGCTTC
TCCCCAAGGAGATGAGGAGCGGTGATGCCAGCACCGGGATGCGCAGAGCACTGGAAGGGCTGGTGCAGATCTACTTCCCATGCAGAAGAG
AAGTCACATCTTCCAGGGAATCGCAATGTTGTGGCGTCTGACTTGTATGTCACATTTGTGTAAAATGGTATATTCTTTAAAATAGTGTTG
ATAACTGGAATATTGTATGTATGCTTGGAGATGCTTTGTGTGAACCTAAGACTGTCACTCAACAGATGTTGGATTGGGGAAAATCCAAAG

>51612_51612_1_MAPKAPK2-SRGAP2_MAPKAPK2_chr1_206858853_ENST00000294981_SRGAP2_chr1_206589249_ENST00000414007_length(amino acids)=760AA_BP=139
MEPGRVGEAGSSPERTSQPVGGRRGGGPEPEEGAAAGTPACAPASPGTMLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQ
FPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARR
SSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDI
FHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTI
IIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRA
SDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFR
SDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEV
IAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMA

--------------------------------------------------------------
>51612_51612_2_MAPKAPK2-SRGAP2_MAPKAPK2_chr1_206858853_ENST00000367103_SRGAP2_chr1_206589249_ENST00000414007_length(transcript)=5350nt_BP=472nt
GAGCCAGCGGCGCGCGGTGGGACCCACGGAGCCCCGCGACCCGCCGAGCCTGGAGCCGGGCCGGGTCGGGGAAGCCGGCTCCAGCCCGGA
GCGAACTTCGCAGCCCGTCGGGGGGCGGCGGGGAGGGGGCCCGGAGCCGGAGGAGGGGGCGGCCGCGGGCACCCCCGCCTGTGCCCCGGC
GTCCCCGGGCACCATGCTGTCCAACTCCCAGGGCCAGAGCCCGCCGGTGCCGTTCCCCGCCCCGGCCCCGCCGCCGCAGCCCCCCACCCC
TGCCCTGCCGCACCCCCCGGCGCAGCCGCCGCCGCCGCCCCCGCAGCAGTTCCCGCAGTTCCACGTCAAGTCCGGCCTGCAGATCAAGAA
GAACGCCATCATCGATGACTACAAGGTCACCAGCCAGGTCCTGGGGCTGGGCATCAACGGCAAAGTTTTGCAGATCTTCAACAAGAGGAC
CCAGGAGAAATTCGCCCTCAAAAAAATGAAAGAGTACCTGGAGGGCAGGAACCTCATCACCAAGTTACAAGCCAAGCATGACCTTCTGCA
GAAAACCCTGGGAGAAAGTCAGCGGACAGATTGCAGTCTAGCCAGGCGCAGCTCAACTGTGAGGAAACAGGACTCCAGCCAGGCAATTCC
TCTGGTGGTGGAAAGCTGTATCCGGTTTATCAGCAGACACGGACTACAGCATGAAGGAATTTTCCGGGTGTCAGGATCCCAGGTGGAAGT
GAATGACATCAAAAATGCCTTTGAGAGAGGAGAGGACCCCCTGGCTGGGGACCAGAACGACCATGACATGGATTCCATAGCTGGTGTCCT
GAAGCTTTACTTCCGGGGGCTGGAACACCCTCTCTTCCCCAAGGACATCTTTCATGACCTGATGGCCTGCGTCACAATGGACAACCTGCA
GGAGAGAGCTCTGCACATCCGGAAAGTCCTCCTAGTCCTGCCCAAAACCACTCTGATTATCATGAGATACCTCTTTGCCTTCCTCAATCA
TTTATCACAGTTCAGTGAAGAGAACATGATGGACCCCTACAACCTCGCCATCTGCTTCGGGCCCTCGCTAATGTCAGTGCCAGAGGGCCA
CGACCAGGTGTCCTGCCAAGCCCACGTGAATGAGCTGATCAAAACCATCATCATCCAGCATGAGAACATCTTCCCAAGCCCCAGGGAGCT
GGAGGGCCCTGTCTACAGCAGAGGAGGAAGCATGGAGGATTACTGTGATAGCCCTCATGGAGAGACTACCTCGGTTGAAGACTCAACCCA
GGATGTGACCGCAGAGCACCACACGAGCGATGACGAATGTGAGCCCATCGAGGCCATTGCCAAGTTTGACTACGTGGGCCGGACAGCCCG
AGAGCTGTCCTTTAAGAAGGGAGCATCCCTGCTGCTTTACCAGCGGGCTTCCGACGACTGGTGGGAAGGCCGGCACAATGGCATCGACGG
ACTCATCCCCCATCAGTACATCGTGGTCCAAGACACCGAGGACGGTGTCGTGGAGAGGTCCAGCCCCAAGTCTGAGATTGAGGTCATTTC
TGAGCCACCTGAAGAAAAGGTGACAGCCAGAGCGGGGGCCAGCTGTCCCAGTGGGGGTCATGTAGCCGATATTTATCTTGCAAACATCAA
CAAGCAAAGGAAGCGTCCAGAATCTGGGAGCATCCGGAAAACTTTTCGGAGTGACAGCCATGGGCTGAGCAGTTCCCTGACTGACTCCTC
CTCCCCAGGGGTGGGGGCTAGCTGCCGCCCATCCTCCCAGCCCATCATGAGCCAGAGCCTCCCCAAAGAAGGGCCAGATAAGTGTTCCAT
CAGTGGGCACGGGAGCCTCAACTCCATCAGCCGCCACTCATCCCTGAAGAATCGGCTGGATAGTCCACAGATCCGGAAGACTGCCACAGC
GGGAAGGTCAAAAAGCTTCAATAACCATCGGCCCATGGACCCTGAGGTCATTGCTCAGGATATTGAGGCAACAATGAACTCGGCCCTGAA
TGAGCTACGGGAACTAGAACGGCAGAGCAGTGTCAAACACACCCCTGACGTGGTTCTGGACACCTTGGAGCCCCTCAAAACCTCCCCAGT
GGTGGCCCCCACGTCAGAGCCCTCCAGCCCTCTGCACACCCAGCTCCTCAAGGACCCCGAGCCCGCCTTCCAGCGCAGCGCCAGTACTGC
TGGGGACATCGCCTGCGCCTTCCGGCCTGTCAAGTCTGTCAAGATGGCTGCCCCGGTCAAACCACCAGCCACACGGCCCAAGCCCACTGT
CTTCCCCAAAACAAATGCCACTAGCCCTGGTGTCAACTCATCAACTTCCCCACAGTCTACTGACAAGTCTTGTACTGTCTGAGGGATAAT
AATTTAATTGTTCTAGACAAGGGGACTATAGGGACTGACTGTTATTAAAATCTTCCTATTTAACTAGCTTGGGGACTTCAGTTGAAAATT
AGGTTCTAAGTTGTTCTTGCAGGAATTAGCCTCCCCGTCTCCCAAAACCTTGAGAATGAAGCCCTTGGTATCGCCTCTCCCTTCCCACTG
CCCTCTGCTTCCCCCAGTCGTCGTAATTCAGCCAGCTGCAGTCCGTACCGTTCTTAGGTTAGCCAGAGACAGGTTTTCATTATCAGGTCA
CTGTGAAATCTGGTAAGGCAGTCCTGAGGACATGGGCTCAAGTCTCAGTCCCCTCAGACCACGGTGATGCCTTGACCAGATGGTTGGCTA
CTGCCATCCAGCTTTCAGTGGCATCTTGTTTTGGGAACTGATTATAGAGAATCATATATAGTCCAGTCTTCATTTTACATACACACACAT
ATTTTACACACACACACATTTTACACACACACACACACACACACACATATGTTTTTCTAGTCTCTGGCATGTGTAGCCTCTCCTGGTCAT
AGACCAGTCTCTTTGTAAGTTATTGTGGCAGTTCACACAGTAGCCACCAGGGGTCTCTGTTTCCATTACAAACTTTGTTCTGTCTGGGCC
AGAGAACCTAGCCTTTGAAATCTCTCCATCATATGAAACATAACGGGATGGGACAATCCCGTAACCTGTTTGGGGTTGGGGGCTTTCTCT
CTGTGTTCTTTCCATTGATGTGAATTGGTCATTGGTGTTTGCTCTTGCCTCTCCTCCATCCCCTAGAAGTACACCCCCGTCTTATTAAGG
AGCTTTTAAAGTTTTTCTGAATGTATAGACATTTCTCGGGTTCCTACCTTTGTCTCTGATGGACCATTTTCCATTTAAGACATTTTCCTG
TATAAGACAGTTTTATAGCTGGTTCCTTTTAGGGTAAAGAGTCTTAAGAGAGTTTTATTGTGTCTATGGCAGGTTTGGGAAAGGTAAGAA
ATGGGTCCTTTTTCCTCCTAATGTTTTTGGCACTTAAAACATAAAATTCATTATCCTATTAAAAAATTAAATTCAGCTTTGCTAATCCAG
AAATTGTTCCCAAATGAAAACTTGTTTTAAGTCCACCCCTTAGTTTCCTTATTTTACAAGGTCTCTCTTCAGGGACCAACAGGGGCTTAG
AGAGCCTTAGTTAGATTAAAGGGAGACCCTACCTCTTAAAACCAGTTTTCATTTATGCAAACAAGGACAATTAAGGGAACCCTGACCCCA
CAGGCTCTCAAGTCTTCCCAAGGCCAGAATCGAAAGAAAATTAAAATTTGAATGCTGAATATTCTGGCTCTACTCTGGCCTTTTTTCTGG
TTCCCTTCCAAAATGCACAAATCATACCCTTGTCTGCTCCAATTCAGTCTCCAAACCTGGTGCCTGTGCTCCTGGCCCCCCTAGCATCAT
GCTATCCCAGGAGTATCAGGACCAGACACATCCACAGCCAGGCTCATGGGTCTCAGACAGCAACTTGAGTTAAAGCTGAAACTCATCCTT
CTTCTCTGTGTTTTCTGGTTTAAAAGCTGCACTTATATTTTAGCCTTATTATTTTCTGTAGTTCCGGAGAGATGGTGGGTTGCCATTCTG
GTAGGAAAATCTGAGTTTTCTTATCTTTGACCTAGAAGAGATTCTTTTTGGACCAACCTGCGAAATTGGTAGTTAGGTCTATGGAAAGTG
GTAGGATTTTTTTTTTTTAATCCTGTGCAAAGGAAAAGAGGTGCTTTGTGGGAAATCACTAATGAGAAGGCTAACCTGCAGCACCAGAGA
AACCTTTCCAAGTGCTAGGCAGGAGAACTGAAGAACTCTTTCAGTGAAGTGAGTCAGCCTAGAAGAGGCAACCCACAGTCTTGATTTTTG
TTGCTGTTTCCTGACCTGTTCTTGCCTGTCACCTGGGCCTACACAGGTCCCGAGCCAACGGGGCTTTCATACCCAAGGATCTGTTTCCTT
GCTGAAAATGAAACCCTATCTTTCACTTTACATTCCTTTCAATCCAACTGATCAAAACTGGTACCCACACTTGCCCTTTCTCCCTCTCTC
CAGCACACTCCCCTCTAAGAAAGTAAAAGCAAAGCTTTCTTAATGGCAACACTTTGGGCCTGTTCTGTTGCTCCTGCCTTATTTCTCTTT
CAACCCTGTACATGACTCGTGTTCACCATCCCCTTGATCAGTGTCCATCCGCGCTAATTTGCATCATGAACTGAACAGTGTGTGAGTGGT
CACCTACTAAACCCAGCTCTGGGGGCAGAGCTGTCTTCCCCATCTCTGGTGCTCCTAACACCTGTGAGATGGTCCTGTCGAGAGGACTAG
GAACCGATAGGAGGAGAGTCCTTCTCGGCAGAGCTCACTGCAAACAACTGGAATTGAGGTTGCACACTGTGATTTTTACACCGAAAAGCC
AAAAGGAGCTGGCCATCCAGGGCCTAGGGAGACCAGCCTTCCTCAGCTATGCTTGCCGAAACCAGCATGATGCTTCAAAGAGCCCTGCTC
CACCCCTCATGGCATGGATCCTTTTCCTGGTGTGGACTCTGAAGGGTCAGTCTTCGGGGAAGAGAGGTGGGGTGGGGCTACTAGCATCCC
AATTTAGAAAACAGAGGAGTTTGTAGCCAGCAGCCTGTAAACTGGAAACACTGGTCTCAGCCAACCTCCTCAGGGCGCCCTGGCTTCTCC
CCAAGGAGATGAGGAGCGGTGATGCCAGCACCGGGATGCGCAGAGCACTGGAAGGGCTGGTGCAGATCTACTTCCCATGCAGAAGAGAAG
TCACATCTTCCAGGGAATCGCAATGTTGTGGCGTCTGACTTGTATGTCACATTTGTGTAAAATGGTATATTCTTTAAAATAGTGTTGATA
ACTGGAATATTGTATGTATGCTTGGAGATGCTTTGTGTGAACCTAAGACTGTCACTCAACAGATGTTGGATTGGGGAAAATCCAAAGCAC

>51612_51612_2_MAPKAPK2-SRGAP2_MAPKAPK2_chr1_206858853_ENST00000367103_SRGAP2_chr1_206589249_ENST00000414007_length(amino acids)=760AA_BP=139
MEPGRVGEAGSSPERTSQPVGGRRGGGPEPEEGAAAGTPACAPASPGTMLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQ
FPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARR
SSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDI
FHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTI
IIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRA
SDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFR
SDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEV
IAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for MAPKAPK2-SRGAP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for MAPKAPK2-SRGAP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for MAPKAPK2-SRGAP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source